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MCID: HYD006
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Hydrocephalus malady |
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Sources: 30NIH Rare Diseases, 23MedlinePlus, 31NINDS, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NINDS: Hydrocephalus is a condition in which the primary characteristic is excessive accumulation of fluid in the brain. Although
hydrocephalus was once known as "water on the brain," the "water" is actually cerebrospinal fluid (CSF) -- a clear fluid surrounding
the brain and spinal cord. The excessive accumulation of CSF results in an abnormal dilation of the spaces in the brain called
ventricles. This dilation causes potentially harmful pressure on the tissues of the brain. Hydrocephalus may be congenital
or acquired. Congenital hydrocephalus is present at birth and may be caused by genetic abnormalities or Acquired hydrocephalus develops at the time of birth or at some point afterward and can affect individuals of all ages. For example, h Symptoms of hydrocephalus vary with age, disease progression, and individual differences in tolerance to CSF. In infancy,
the most obvious indication of hydrocephalus is often the rapid increase in head circumference or an unusually large head
size. In older children and adults, symptoms may include headache followed by vomiting, nausea, papilledema (swelling of the
optic disk, which is part of the optic nerve), downward deviation of the eyes (called "sunsetting"), problems with balance,
poor coordination, gait disturbance, urinary incontinence, slowing or loss of development (in children), lethargy, drowsiness,
irritability, or other changes in personality or cognition, including memory loss. Hydrocephalus is diagnosed through clinical
neurological evaluation and by using cranial imaging techniques such as ultrasonography, computer tomography (CT), magnetic
resonance imaging (MRI), or pressure-monitoring techniques.31
MalaCards: Hydrocephalus, also known as hydrocephalus (disorder), is related to normal pressure hydrocephalus and obstructive hydrocephalus. An important gene associated with Hydrocephalus is L1CAM (L1 cell adhesion molecule), and among its related pathways are Actin-Based Motility by Rho Family GTPases and ERK5 Signaling. The compounds tyrosine and serine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are skeleton and reproductive system. NIH Rare Diseases: Hydrocephalus is a condition characterized by excessive accumulation of fluid in the brain. Although it was once known as "water on the brain," the "water" is actually cerebrospinal fluid (CSF) - clear fluid that surrounds the brain and spinal cord. Excess CSF builds up when it cannot drain from the brain due to a blockage in a passage through which the fluid normally flows. This excess fluid causes an abnormal widening of spaces in the brain called ventricles; this can create harmful pressure on brain tissue. Symptoms vary with age, disease progression, and individual differences in tolerance to the condition. Hydrocephalus may be congenital (present at birth) or acquired. The causes are not fully understood; it may result from inherited genetic abnormalities or developmental disorders; complications of premature birth; diseases such as meningitis; tumors; traumatic head injury; or other causes. It is most often treated by surgically inserting a shunt system.30 MedlinePlus: Hydrocephalus is the buildup of too much cerebrospinal fluid in the brain. normally, this fluid cushions your brain. when you have too much, though, it puts harmful pressure on your brain. there are two kinds of hydrocephalus. congenital hydrocephalus is present at birth. causes include genetic problems and problems with how the fetus develops. an unusually large head is the main sign of congenital hydrocephalus. acquired hydrocephalus can occur at any age. causes can include head injuries, strokes, infections, tumors and bleeding in the brain. symptoms of acquired hydrocephalus can include headache vomiting and nausea blurry vision balance problems bladder control problems thinking and memory problems hydrocephalus can permanently damage the brain, causing problems with physical and mental development. if untreated, it is usually fatal. with treatment, many people lead normal lives with few limitations. treatment usually involves surgery to insert a shunt. medicine and rehabilitation therapy can also help. nih: national institute of neurological disorders and stroke23 Wikipedia: Hydrocephalus (pron.: /ˌhaɪdrɵˈsɛfələs/), also known as \"water on the brain,\" is a medical...44 more... |
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 17Genetics Home Reference, 31NINDS, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 33OMIM, 40SNOMED-CT, 24MeSH, 27NCIt See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for hydrocephalus Drug clinical trials:Search ClinicalTrials for hydrocephalus Search NIH Clinical Center for hydrocephalus Search CenterWatch for hydrocephalus |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to hydrocephalus:22Brain, Spinal cord, Heart, Kidney, Liver, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Pituitary
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to hydrocephalus:25 (show all 30)
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Sources: 35PubMed See all sources |
Articles related to hydrocephalus:(show top 50) (show all 109)
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Sources: 1BioGPS See all sources |
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Sources: 36QIAGEN, 37R&D Systems, 20KEGG See all sources |
Pathways related to hydrocephalus according to GeneDecks:(show top 50) (show all 67)
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Sources: 32Novoseek , 9DrugBank, 42Tocris Bioscience, 18HMDB, 34PharmGKB See all sources |
Compounds related to hydrocephalus according to GeneDecks:(show top 50) (show all 264)
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Sources: 12Gene Ontology See all sources |
Cellular components related to hydrocephalus according to GeneDecks:
Biological processes related to hydrocephalus according to GeneDecks:(show all 31)
Molecular functions related to hydrocephalus according to GeneDecks:(show all 7)
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