MCID: HYD002
MIFTS: 48

Hydronephrosis malady

Summaries for Hydronephrosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hydronephrosis — literally \"water inside the kidney\" — refers to distension and dilation of the... more...

MalaCards: Hydronephrosis, also known as hydronephrosis nos, is related to ureteral obstruction and vesicoureteral reflux. An important gene associated with Hydronephrosis is AQP2 (aquaporin 2 (collecting duct)), and among its related pathways is Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds iopentol and p-aminohippuric acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and lung, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Hydronephrosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

hydronephrosis 8 10 45 61
hydronephrosis nos 8


External Ids:

Disease Ontology8 DOID:11111
NCIt40 C26796
ICD9CM27 591
MeSH35 D006869

Related Diseases for Hydronephrosis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the congenital hydronephrosis family:

hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 279)
idRelated DiseaseScoreTop Affiliating Genes
1ureteral obstruction30.4CLU, AMBP
2vesicoureteral reflux30.4AMBP, UPK1B, UPK3A, AGTR2, NAGLU, PLEKHF1
3nephrogenic diabetes insipidus30.3SLC12A1, AQP2
4urinary tract obstruction30.2AQP2
5renal agenesis30.1AGTR2
6transitional cell carcinoma30.0UPK1B
7bladder carcinoma29.9UPK3A, CLU
8congenital hydronephrosis10.8
9horseshoe kidney10.3
10diabetes insipidus10.2
11urofacial syndrome10.2
12actinomycosis10.2
13tuberculosis10.1
14urethral obstruction10.1
15coloboma porencephaly hydronephrosis10.1
16retroperitoneal fibrosis10.1
17schinzel giedion syndrome10.1
18renal dysplasia10.1
19ureterocele10.0
20polyhydramnios10.0
21megacystis microcolon intestinal hypoperistalsis syndrome10.0
22okamoto syndrome10.0
23spinal cord injury10.0
24primary hyperoxaluria10.0AMBP
25kidney cancer10.0ZNF135
26hypertension10.0MME
27ovarian brenner tumor10.0UPK3A
28congestive heart failure10.0MME
29acute myocardial infarction10.0CLU, NAGLU
30fallopian tube cancer10.0B2M, NAGLU
31urinary system disease10.0B2M, NAGLU
32chronic pyelonephritis10.0B2M, NAGLU
33lymphomatoid papulosis10.0CLU
34pyelonephritis10.0AMBP, B2M, NAGLU
35peritonitis10.0B2M
36acute kidney failure10.0AMBP, B2M, NAGLU
37dementia10.0CLU, AMBP
38metabolic acidosis10.0B2M, SLC12A1, AQP2
39essential hypertension10.0AGTR2, NAGLU, MME, SLC12A1, AQP2
40hypertrophy of breast10.0ID2, AGTR2, AHR, CLU
41ischemia10.0MME, CLU, NAGLU, AGTR2
42diabetic nephropathy10.0AMBP, B2M, AGTR2, NAGLU, AQP2
43liver cirrhosis10.0AQP2, ID2
44nephrotic syndrome10.0CLU, NAGLU, B2M, AMBP
45proteinuria10.0AMBP, B2M, AGTR2, NAGLU, CLU
46cystic fibrosis10.0AMBP, MME, AQP2
47glomerulonephritis10.0AMBP, B2M, NAGLU, CLU, MME
48bladder leiomyoma9.9
49anuria9.9
50erdheim-chester disease9.9

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to hydronephrosis

Clinical Features for Hydronephrosis

Drugs & Therapeutics for Hydronephrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hydronephrosis

Drug clinical trials:

Search ClinicalTrials for Hydronephrosis

Search NIH Clinical Center for Hydronephrosis

Search CenterWatch for Hydronephrosis

Genetic Tests for Hydronephrosis

Anatomical Context for Hydronephrosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Hydronephrosis:

33
Spinal cord, Kidney, Lung, Uterus, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Pancreas, Breast, Prostate, Testis, Cervix, Monocytes, T cells, B cells, Fetal lung, Pituitary

Animal Models for Hydronephrosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hydronephrosis

Sources:
51PubMed
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Articles related to Hydronephrosis:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Acute kidney injuries induced by various irrigation pressures in rat models of mild and severe hydronephrosis. (24144540)
2013
2
Re: Management trends in prenatally detected hydronephrosis: national survey of pediatrician practice patterns and antibiotic use. (24209566)
2013
3
Response to 'Re: Nerli RB, Reddy MN, Hiremath MB, Shishir D, Patil SM, Guntaka A. Surgical outcomes of laparoscopic dismembered pyeloplasty in children with giant hydronephrosis secondary to ureteropelvic junction obstruction. J Pediatr Urol 2011 Sep 12 [Epub ahead of print]'. (22695377)
2013
4
The predictive factors of hydronephrosis in patients with spina bifida: reports from China. (23483305)
2013
5
Unilateral hydronephrosis and renal damage after acute leukemia. (22548083)
2012
6
Evaluation and outcome of antenatal hydronephrosis: a prospective study. (22506510)
2012
7
Antegrade pressure measurement of urinary tract in children with persistent hydronephrosis. (22951173)
2012
8
Decrease of renal aquaporins 1-4 is associated with renal function impairment in pediatric congenital hydronephrosis. (23151861)
2012
9
A rare case of an appendiceal mass masquerading as a pelvic tumour and causing bilateral hydronephrosis. (22970067)
2012
10
Late migration of a toothpick into the bladder: initial presentation with urosepsis and hydronephrosis. (22832645)
2012
11
Feasibility of measuring 3-dimensional renal parenchymal volume to predict postnatal renal function in near-term fetuses with congenital hydronephrosis: a preliminary study. (22644693)
2012
12
Postnatal evaluation and outcome of infants with antenatal hydronephrosis. (22649872)
2011
13
An unusual cause of anuria and hydronephrosis in a 12-year-old girl. (21463179)
2011
14
Renal arteriovenous fistula simulating hydronephrosis: A case report. (23397018)
2011
15
The prognostic value of hydronephrosis in bladder cancer treated by radical cystectomy. (21452155)
2011
16
The effects of hydronephrosis and stone burden on success rates of shockwave lithotripsy in pediatric population. (20491595)
2010
17
Laparoscopic vascular relocation: alternative treatment for renovascular hydronephrosis in children. (20512343)
2010
18
Horseshoe kidney with giant hydronephrosis secondary to ureteropelvic junction obstruction. (19914649)
2010
19
Pelvic reduction during pyeloplasty for antenatal hydronephrosis: does it affect outcome in ultrasound and nuclear scan postoperatively? (20035979)
2010
20
Bladder tumour diagnosed in a case presenting with uterine leiomyoma and hydronephrosis. (19603338)
2009
21
Renal colic in pregnancy: lithiasis or physiological hydronephrosis? (19660792)
2009
22
Requirements for accurately diagnosing chronic partial upper urinary tract obstruction in children with hydronephrosis. (18074126)
2008
23
Imaging kidney in conscious rats with high-frequency ultrasound and detection of two cases of unilateral congenital hydronephrosis. (17188800)
2007
24
Hydronephrosis as a prognostic marker in bladder cancer in a cystectomy-only series. (16904815)
2007
25
MA1llerianosis of ureter: a rare cause of hydronephrosis. (17572222)
2007
26
Grade of hydronephrosis and tumor diameter as preoperative prognostic factors in ureteral transitional cell carcinoma. (17991533)
2007
27
Do hydronephrosis and extracorporeal shock wave lithotripsy affect carbohydrate antigens? (17334832)
2007
28
Prenatal diagnosis of a 11q deletion syndrome associated with unilateral hydronephrosis diagnosed by 3D ultrasound examination. (17729374)
2007
29
The frequency of hydronephrosis at initial diagnosis and its effect on recurrence and progression in patients with superficial bladder cancer. (17632171)
2007
30
Comparative study of conservative and surgical management for symptomatic moderate and severe hydronephrosis in pregnancy: a prospective randomized study. (17712643)
2007
31
The magnitude of fetal renal pelvic dilatation can identify obstructive postnatal hydronephrosis, and direct postnatal evaluation and management. (16813930)
2006
32
Magnetic resonance urographic parameters for predicting the need for pyeloplasty in infants with prenatally diagnosed severe hydronephrosis. (16945648)
2006
33
Presacral epidermoid cyst with right hydronephrosis. (17197358)
2006
34
Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. (16641094)
2006
35
Prenatal hydronephrosis. (16716789)
2006
36
Giant hydronephrosis mimicking echinococcal cyst. (16453224)
2005
37
Giant seminal vesicle cyst resembling megaureter with hydronephrosis. (16087565)
2005
38
Congenital diaphragmatic eventration and bilateral uretero-hydronephrosis in a patient with neonatal Marfan syndrome caused by a mutation in exon 25 of the FBN1 gene and review of the literature. (14586646)
2004
39
Strategies for the Management of Exstrophy, Nonpalpable Testis, Hydronephrosis: Highlights From the Annual Meeting of the American Academy of Pediatrics Section on Urology October 9-12, 1999, Washington, DC. (16985737)
2000
40
Unilateral hydronephrosis and recurrent endometrial stromal sarcoma with review of the literature. (10443046)
1999
41
Congenital hydronephrosis who requires intervention? (11178607)
1999
42
Hereditary nephrogenic diabetes insipidus and bilateral nonobstructive hydronephrosis. (8289981)
1993
43
Infantile hypertrophic pyloric stenosis and hydronephrosis: is there an association? (8510237)
1993
44
Traumatic rupture of the urinary tract in a patient presenting nephrogenic diabetes insipidus associated with hydronephrosis and chronic renal failure: case report and review of the literature. (1424306)
1992
45
Hydronephrosis, renal agenesis, and associated genitourinary anomalies in ACI rats. (622762)
1978
46
The diagnosis of fetal hydronephrosis, megaureter and urethral obstruction by ultrasonic echography. (1168479)
1975
47
Ultrasound in diagnosis of congenital hydronephrosis due to obstruction of pelviureteric junction. (163509)
1975
48
A clinical and histological study on congenital hydronephrosis with special reference to hypertension. (6073285)
1967
49
Congenital hydronephrosis in the African. (6075855)
1967
50
Large hydronephrosis simulating ovarian cyst. (13151479)
1953

Genetic Variations for Hydronephrosis

Expression for genes affiliated with Hydronephrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hydronephrosis

Search GEO for disease gene expression data for Hydronephrosis.

Pathways for genes affiliated with Hydronephrosis

Sources:
50PharmGKB, 38NCBI BioSystems Database
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Pathways related to Hydronephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1MME, AGTR2

Compounds for genes affiliated with Hydronephrosis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Hydronephrosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1iopentol4510.5B2M, NAGLU
2p-aminohippuric acid4510.5B2M, NAGLU
3tobramycin4510.5B2M, NAGLU
4fosfomycin4510.5B2M, NAGLU
5mesna4510.5NAGLU, B2M
6aluminium45 1111.4NAGLU, B2M
7desmopressin45 60 29 1113.4AQP2, NAGLU, B2M
8mercury4510.3AQP2, NAGLU, AMBP
9captopril45 29 50 60 1114.3MME, AGTR2, B2M
1099mtc-dmsa4510.3AMBP, B2M, NAGLU
11amikacin4510.3AMBP, B2M, NAGLU
12dmsa4510.3AMBP, B2M, NAGLU
13iohexol4510.3AMBP, B2M, NAGLU
14hanp4510.3AMBP, B2M
15furosemide45 50 60 29 11 2415.3AQP2, SLC12A1, MME, NAGLU
16ifosfamide45 1111.3NAGLU, B2M, AMBP
17calcium oxalate4510.2NAGLU, AMBP
18enalapril45 50 1112.2AMBP, AGTR2, NAGLU, MME
19cadmium45 2411.2NAGLU, B2M, AMBP
20inulin4510.1CLU, NAGLU, B2M, AMBP
21aprotinin45 1111.1MME, NAGLU, AMBP
22prostaglandin4510.1AQP2, MME, AGTR2, AMBP
23lead4510.1AMBP, B2M, NAGLU, MME
24trichloroethylene4510.1AMBP, NAGLU
25vitamin-e4510.1B2M, NAGLU, MME
26uric acid45 2411.1NAGLU, B2M, AMBP
27chloride4510.0B2M, CLU, MME, SLC12A1, AQP2
28vitamin a45 11 2412.0MME, NAGLU, B2M, AMBP
29pge24510.0B2M, AHR, MME, SLC12A1, AQP2
30urea45 11 2412.0AMBP, B2M, NAGLU, SLC12A1, AQP2
31ulinastatin4510.0AMBP, NAGLU
32potassium45 11 2412.0AMBP, NAGLU, MME, SLC12A1, AQP2
33cycloheximide459.9B2M, AGTR2, AHR, CLU, MME
34cisplatin45 50 60 1112.9AMBP, B2M, NAGLU, CLU, AQP2
35vitamin d459.9CLU, NAGLU, AHR, B2M
36lactate459.8AMBP, B2M, NAGLU, CLU, MME
37cyclosporin a45 29 6011.8AMBP, B2M, AGTR2, NAGLU, MME, AQP2
38creatinine459.8AMBP, B2M, AGTR2, NAGLU, MME, AQP2
39alanine459.7AMBP, B2M, AGTR2, AHR, NAGLU, AQP2
40sodium45 2410.7AMBP, B2M, AGTR2, NAGLU, MME, SLC12A1
41estrogen459.7ID2, B2M, AGTR2, AHR, CLU, MME
42steroid459.6AMBP, B2M, AHR, NAGLU, CLU, MME
43dexamethasone45 50 29 1112.6AQP2, MME, CLU, AHR, ID2
44cysteine459.6AMBP, B2M, AHR, NAGLU, CLU, MME
45retinoic acid45 2410.5AMBP, ID2, B2M, AHR, CLU, MME
46calcium45 50 11 2411.8AMBP, B2M, AGTR2, NAGLU, CLU, MME

GO Terms for genes affiliated with Hydronephrosis

Products for genes affiliated with Hydronephrosis

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Sources for Hydronephrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet