MCID: HYD002
MIFTS: 48

Hydronephrosis malady

Summaries for Hydronephrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hydronephrosis — literally \"water inside the kidney\" — refers to distension and dilation of the... more...

MalaCards: Hydronephrosis, also known as hydronephrosis nos, is related to ureteral obstruction and hypertension. An important gene associated with Hydronephrosis is AQP2 (aquaporin 2 (collecting duct)), and among its related pathways is Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds iopentol and p-aminohippuric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, testis and spinal cord, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Hydronephrosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

hydronephrosis 8 10 44 60
hydronephrosis nos 8


External Ids:

Disease Ontology8 DOID:11111
NCIt39 C26796
ICD9CM27 591
MeSH34 D006869

Related Diseases for Hydronephrosis

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17GeneCards, 18GeneDecks
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Diseases in the Congenital Hydronephrosis family:

hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1ureteral obstruction30.5CLU, AMBP
2hypertension30.4MME
3pyelonephritis30.4AMBP, B2M, NAGLU
4vesicoureteral reflux30.4AMBP, UPK1B, UPK3A, AGTR2, NAGLU, PLEKHF1
5nephrogenic diabetes insipidus30.3SLC12A1, AQP2
6urinary tract obstruction30.1AQP2
7renal agenesis30.1AGTR2
8chronic pyelonephritis30.1B2M, NAGLU
9transitional cell carcinoma30.0UPK1B
10peritonitis30.0B2M
11bladder carcinoma29.8UPK3A, CLU
12diabetes insipidus10.2
13urofacial syndrome10.2
14actinomycosis10.2
15urethritis10.1
16endometriosis10.1
17hydrocele10.1
18renal hypertension10.1
19tuberculosis10.1
20urethral obstruction10.1
21vaginitis10.1
22okamoto syndrome10.1
23multicystic renal dysplasia, bilateral10.1
24congenital hydronephrosis10.1
25wegener's granulomatosis10.0
26ureterocele10.0
27polyhydramnios10.0
28leiomyoma10.0
29pancreatitis10.0
30megacystis microcolon intestinal hypoperistalsis syndrome10.0
31coloboma porencephaly hydronephrosis10.0
32primary hyperoxaluria10.0AMBP
33kidney cancer10.0ZNF135
34ovarian brenner tumor10.0UPK3A
35congestive heart failure10.0MME
36acute myocardial infarction10.0CLU, NAGLU
37fallopian tube cancer10.0B2M, NAGLU
38urinary system disease10.0B2M, NAGLU
39lymphomatoid papulosis10.0CLU
40acute kidney failure10.0AMBP, B2M, NAGLU
41dementia10.0CLU, AMBP
42metabolic acidosis10.0B2M, SLC12A1, AQP2
43essential hypertension10.0AGTR2, NAGLU, MME, SLC12A1, AQP2
44hypertrophy of breast10.0ID2, AGTR2, AHR, CLU
45ischemia10.0MME, CLU, NAGLU, AGTR2
46diabetic nephropathy10.0AMBP, B2M, AGTR2, NAGLU, AQP2
47liver cirrhosis10.0AQP2, ID2
48nephrotic syndrome10.0CLU, NAGLU, B2M, AMBP
49proteinuria10.0AMBP, B2M, AGTR2, NAGLU, CLU
50cystic fibrosis10.0AMBP, MME, AQP2

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to hydronephrosis

Clinical Features for Hydronephrosis

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Drugs & Therapeutics for Hydronephrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hydronephrosis

Drug clinical trials:

Search ClinicalTrials for Hydronephrosis

Search NIH Clinical Center for Hydronephrosis

Search CenterWatch for Hydronephrosis

Genetic Tests for Hydronephrosis

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Anatomical Context for Hydronephrosis

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32MalaCards
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MalaCards organs/tissues related to Hydronephrosis:

32
Kidney, Testis, Spinal cord, Cervix, Breast, Uterus, Colon, Smooth muscle, Heart, B cells, Monocytes, Fetal lung, Testes, Prostate, Bone, Pancreas, Lung, Pituitary

Animal Models for Hydronephrosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hydronephrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.4ID2, B2M, AGTR2, AHR, ACD, ZIC3
2MP:00053899.1ZIC3, AMBP, ID2, B2M, AHR, SLC12A1
3MP:00053858.9ZIC3, B2M, TBX18, AGTR2, AHR, NAGLU
4MP:00053788.9ZIC3, ID2, B2M, TBX18, AGTR2, AHR
5MP:00053678.7AQP2, ID2, UPK3A, TBX18, AGTR2, AHR
6MP:00053868.7ZIC3, AMBP, ID2, AGTR2, NAGLU, SLC12A1
7MP:00107718.6AGTR2, TBX18, B2M, ID2, AHR, NAGLU
8MP:00107688.5TBX18, B2M, ID2, ZIC3, AGTR2, AHR

Publications for Hydronephrosis

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50PubMed
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Articles related to Hydronephrosis:

(show top 50)    (show all 659)
idTitleAuthorsYear
1
Co-occurrence of hemiscrotal agenesis with cutis marmorata telangiectatica congenita and hydronephrosis affecting the same side of the body. (24243754)
2014
2
A rare cause of hydronephrosis: entrapment effect of giant iliac artery aneurysm. (23742815)
2013
3
Antenatally diagnosed hydronephrosis: current postnatal management. (23325322)
2013
4
Rare cause of hydronephrosis. (23527316)
2013
5
Early postoperative ultrasound after open pyeloplasty in children with prenatal hydronephrosis helps identify low risk of recurrent obstruction. (23088981)
2012
6
Does hydronephrosis predict the presence of severe vesicoureteral reflux? (22735979)
2012
7
Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosis. (22150692)
2012
8
Laparoscopic management of sacral neurinoma causing hydronephrosis. (22610845)
2012
9
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
10
Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. (21460193)
2011
11
Retroperitoneoscopic nephrectomy for symptomatic hydronephrosis using a SAND balloon catheter. (21745100)
2011
12
Question from the clinician: management of prenatal hydronephrosis. (22135428)
2011
13
Resolution of hydronephrosis after uterine artery embolization for fibroids. (21507679)
2011
14
A prospective study on the prevalence of hydronephrosis in women with pelvic organ prolapse and their outcomes after treatment. (21822714)
2011
15
Images in clinical medicine. Nonobstructive hydronephrosis with secondary polycythemia. (21732830)
2011
16
Repression of apurinic/apyrimidinic endonuclease by p53-dependent apoptosis in hydronephrosis-induced rat kidney. (21473738)
2011
17
Hydronephrosis after embolization of internal iliac artery aneurysms. (20138546)
2010
18
Preoperative hydronephrosis, ureteroscopic biopsy grade and urinary cytology can improve prediction of advanced upper tract urothelial carcinoma. (20478585)
2010
19
Relative renal function with MAG-3 and DMSA in children with unilateral hydronephrosis. (20640539)
2010
20
Comparison of dismembered and nondismembered Y-V laparoscopic pyeloplasty in patients with primary hydronephrosis. (20059324)
2010
21
Abdominal cerebrospinal fluid (CSF) pseudocyst presented with inferior vena caval obstruction and hydronephrosis. (20623127)
2010
22
Calyceal plication with Anderson-Hynes pyeloplasty in a 7-year-old boy with giant hydronephrosis of a single right kidney. (19212938)
2009
23
Expression of renal aquaporins is down-regulated in children with congenital hydronephrosis. (19757329)
2009
24
Long-term nephrostomy in an adult male spinal cord injury patient who had normal upper urinary tracts but developed bilateral hydronephrosis following penile sheath drainage: pyeloplasty and balloon dilatation of ureteropelvic junction proved futile: a case report. (20062594)
2009
25
Postnatal imaging of antenatal hydronephrosis. (19484160)
2009
26
Ultrasound Scanning in Fetal Renal Pelvis Dilatation: not only Hydronephrosis. (22439049)
2009
27
Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks. (18085527)
2008
28
Critical role of cyclooxygenase-2 activation in pathogenesis of hydronephrosis caused by lactational exposure of mice to dioxin. (18606429)
2008
29
Diuretic renography in hydronephrosis: delayed tissue tracer transit accompanies both functional decline and tissue reorganization. (18552148)
2008
30
Breast carcinoma metastasizing to the urinary bladder presenting as bilateral hydronephrosis treated with ureteral stenting and chemotherapy. (17483026)
2007
31
Mature cystic renal teratoma in a 25-year-old woman with ipsilateral hydronephrosis, urinary tract infection and spontaneous abortion. (17508953)
2007
32
Antenatal isolated hydronephrosis associated with urinoma. (18947706)
2007
33
Fetal hydronephrosis; prevalence, natural history and postnatal consequences in an unselected population. (17943467)
2007
34
Impact of stone size, location, composition, impaction, and hydronephrosis on the efficacy of holmium:YAG-laser ureterolithotripsy. (17459573)
2007
35
Conservative treatment of ureteropelvic junction obstruction in children with antenatal diagnosis of hydronephrosis: lessons learned after 16 years of follow-up. (16504374)
2006
36
Management of neonatal hydronephrosis. (16427220)
2006
37
Unilateral nephrectomy for hydronephrosis in a pet rabbit. (16931384)
2006
38
Antenatal hydronephrosis as a predictor of postnatal outcome: a meta-analysis. (16882811)
2006
39
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. (16352741)
2005
40
Effect of the size of regions of interest on the estimation of differential renal function in children with congenital hydronephrosis. (11891468)
2002
41
Increased transforming growth factor-beta1 and tubulointerstitial fibrosis in rats with congenital hydronephrosis. (12410929)
2002
42
Further report of a patient with humeroradioulnar synostosis and hydronephrosis. (7897637)
1995
43
SGP-2 expression as a genetic marker of progressive cellular pathology in experimental hydronephrosis. (1895664)
1991
44
Current status of fetal intervention for congenital hydronephrosis. (6350619)
1983
45
Correction of congenital hydronephrosis in utero II. Decompression reverses the effects of obstruction on the fetal lung and urinary tract. (7161685)
1982
46
Simple chemotherapy for bladder lymphoma with bilateral hydronephrosis. (582422)
1978
47
Hydronephrosis, bacteriuria, and maximal urine concentration in urinary schistosomiasis. (5091567)
1971
48
Congenital hydronephrosis as a cause of abdominal symptoms. (5826998)
1965
49
Bifid renal pelvis as a factor in upper pole hydronephrosis following operation for congenital hydronephrosis. (13824212)
1959
50
III. Primary (Congenital) Hydronephrosis: Report of a Case with Remarks on the Treatment and Pathology. (17862605)
1910

Genetic Variations for Hydronephrosis

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Expression for genes affiliated with Hydronephrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hydronephrosis

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Pathways for genes affiliated with Hydronephrosis

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49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Hydronephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1MME, AGTR2

Compounds for genes affiliated with Hydronephrosis

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Hydronephrosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1iopentol4410.5B2M, NAGLU
2p-aminohippuric acid4410.5B2M, NAGLU
3tobramycin4410.5B2M, NAGLU
4fosfomycin4410.5B2M, NAGLU
5mesna4410.5NAGLU, B2M
6aluminium44 1111.4NAGLU, B2M
7desmopressin44 59 28 1113.4AQP2, NAGLU, B2M
8mercury4410.3AQP2, NAGLU, AMBP
9captopril44 28 49 59 1114.3MME, AGTR2, B2M
1099mtc-dmsa4410.3AMBP, B2M, NAGLU
11amikacin4410.3AMBP, B2M, NAGLU
12dmsa4410.3AMBP, B2M, NAGLU
13iohexol4410.3AMBP, B2M, NAGLU
14hanp4410.3AMBP, B2M
15furosemide44 49 59 28 11 2415.3AQP2, SLC12A1, MME, NAGLU
16ifosfamide44 1111.3NAGLU, B2M, AMBP
17calcium oxalate4410.2NAGLU, AMBP
18enalapril44 49 1112.2AMBP, AGTR2, NAGLU, MME
19cadmium44 2411.2NAGLU, B2M, AMBP
20inulin4410.1CLU, NAGLU, B2M, AMBP
21aprotinin44 1111.1MME, NAGLU, AMBP
22prostaglandin4410.1AQP2, MME, AGTR2, AMBP
23lead4410.1AMBP, B2M, NAGLU, MME
24trichloroethylene4410.1AMBP, NAGLU
25vitamin-e4410.1B2M, NAGLU, MME
26uric acid44 2411.1NAGLU, B2M, AMBP
27chloride4410.0B2M, CLU, MME, SLC12A1, AQP2
28vitamin a44 11 2412.0MME, NAGLU, B2M, AMBP
29pge24410.0B2M, AHR, MME, SLC12A1, AQP2
30urea44 11 2412.0AMBP, B2M, NAGLU, SLC12A1, AQP2
31ulinastatin4410.0AMBP, NAGLU
32potassium44 11 2412.0AMBP, NAGLU, MME, SLC12A1, AQP2
33cycloheximide449.9B2M, AGTR2, AHR, CLU, MME
34cisplatin44 49 59 1112.9AMBP, B2M, NAGLU, CLU, AQP2
35vitamin d449.9CLU, NAGLU, AHR, B2M
36lactate449.8AMBP, B2M, NAGLU, CLU, MME
37cyclosporin a44 28 5911.8AMBP, B2M, AGTR2, NAGLU, MME, AQP2
38creatinine449.8AMBP, B2M, AGTR2, NAGLU, MME, AQP2
39alanine449.7AMBP, B2M, AGTR2, AHR, NAGLU, AQP2
40sodium44 2410.7AMBP, B2M, AGTR2, NAGLU, MME, SLC12A1
41estrogen449.7ID2, B2M, AGTR2, AHR, CLU, MME
42steroid449.6AMBP, B2M, AHR, NAGLU, CLU, MME
43dexamethasone44 49 28 1112.6AQP2, MME, CLU, AHR, ID2
44cysteine449.6AMBP, B2M, AHR, NAGLU, CLU, MME
45retinoic acid44 2410.5AMBP, ID2, B2M, AHR, CLU, MME
46calcium44 49 11 2411.8AMBP, B2M, AGTR2, NAGLU, CLU, MME

GO Terms for genes affiliated with Hydronephrosis

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Products for genes affiliated with Hydronephrosis

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  • Antibodies
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  • Lysates
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Sources for Hydronephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet