MCID: HYD002
MIFTS: 52

Hydronephrosis malady

Nephrological diseases, Fetal diseases, Rare diseases categories
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Summaries for Hydronephrosis

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Wikipedia:65 Hydronephrosis ? literally \"water inside the kidney\" ? refers to distension and dilation of the renal... more...

MalaCards based summary: Hydronephrosis is related to vesicoureteral reflux and renal agenesis. An important gene associated with Hydronephrosis is AQP2 (aquaporin 2 (collecting duct)). The compounds mercury and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, spinal cord and testis, and related mouse phenotypes are liver/biliary system and muscle.

Aliases & Classifications for Hydronephrosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Hydronephrosis, Aliases & Descriptions:

Name: Hydronephrosis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:11111
ICD9CM27 591
MeSH34 D006869
NCIt39 C26796

Related Diseases for Hydronephrosis

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Diseases in the Congenital Hydronephrosis family:

hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1vesicoureteral reflux30.6AGTR2, NAGLU
2renal agenesis30.6AGTR2
3acute pyelonephritis30.5NAGLU
4breast cancer28.9AHR, NAGLU, HMOX1, AGTR2
5congenital hydronephrosis10.8
6ureteral obstruction10.4
7horseshoe kidney10.4
8pyelonephritis10.3
9hypertension10.3
10diabetes insipidus10.2
11urofacial syndrome10.2
12nephrogenic diabetes insipidus10.2
13actinomycosis10.2
14urethritis10.2
15aneurysm10.2
16spinal cord injury10.2
17endometriosis10.2
18hydrocele10.2
19multicystic renal dysplasia, bilateral10.2
20retroperitoneal fibrosis10.2
21cystitis10.1
22tuberculosis10.1
23urethral obstruction10.1
24vaginitis10.1
25okamoto syndrome10.1
26schinzel giedion syndrome10.1
27ureterocele10.1
28polyhydramnios10.1
29chronic pyelonephritis10.1
30leiomyoma10.1
31pancreatitis10.1
32peritonitis10.1
33transitional cell carcinoma10.1
34urinary tract obstruction10.1
35coloboma porencephaly hydronephrosis10.1
36megacystis microcolon intestinal hypoperistalsis syndrome10.1
37renal dysplasia10.1
38congenital heart disease10.0AGTR2, HMOX1
39cervical cancer10.0
40crohn's disease10.0
41diabetes mellitus10.0
42nephrolithiasis10.0
43obesity10.0
44anuria10.0
45neurogenic bowel10.0
46bladder neck obstruction10.0
47renal tuberculosis10.0
48erdheim-chester disease10.0
49wegener's granulomatosis10.0
50blepharophimosis10.0

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to hydronephrosis

Symptoms for Hydronephrosis

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Drugs & Therapeutics for Hydronephrosis

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Drug clinical trials:

Search ClinicalTrials for Hydronephrosis

Search NIH Clinical Center for Hydronephrosis

Genetic Tests for Hydronephrosis

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Anatomical Context for Hydronephrosis

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MalaCards organs/tissues related to Hydronephrosis:

32
Kidney, Spinal cord, Testis, Breast, Cervix, Heart, Smooth muscle, Colon, Uterus, Prostate, Bone, Lung, Pancreas, Testes, Monocytes, B cells, Fetal lung, Pituitary

Animal Models for Hydronephrosis or affiliated genes

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MGI Mouse Phenotypes related to Hydronephrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5AHR, NAGLU, HMOX1
2MP:00053698.5AGTR2, HMOX1, AHR
3MP:00107718.2AHR, AQP2, NAGLU, AGTR2
4MP:00053978.2HMOX1, NAGLU, AQP2, AHR
5MP:00053858.1AHR, NAGLU, HMOX1, AGTR2
6MP:00053767.8AGTR2, HMOX1, AQP2, AHR
7MP:00053677.8AGTR2, HMOX1, NAGLU, AQP2, AHR
8MP:00053867.7AHR, AQP2, NAGLU, HMOX1, AGTR2
9MP:00053787.7AHR, AQP2, NAGLU, HMOX1, AGTR2
10MP:00107687.7AGTR2, HMOX1, NAGLU, AQP2, AHR

Publications for Hydronephrosis

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Articles related to Hydronephrosis:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Variability in Use of Voiding Cystourethrogram During Initial Evaluation of Infants With Congenital Hydronephrosis. (24397941)
2014
2
Congential lumbar hernia with malrotation of left kidney and hydronephrosis in an infant: a rare presentation. (25177616)
2014
3
Relationship between renal apparent diffusion coefficient values and glomerular filtration rate in infants with congenital hydronephrosis. (25382444)
2014
4
Elevation of Ca 125 in a patient with giant congenital hydronephrosis]. (23589602)
2013
5
Rare case of atrophic ectopic kidney with giant hydronephrosis in a 7-year-old girl. (23290143)
2013
6
Laparoscopic Anderson-Hynes pyeloplasty without symphysiotomy for hydronephrosis with horseshoe kidney. (23710906)
2013
7
Giant Urinary Bladder and Bilateral Giant Hydronephrosis due to Bladder Neck Obstruction: One Case Report and Literature Review. (22606637)
2012
8
Frequency and etiology of unexplained bilateral hydronephrosis in patients with breast cancer: results of a longitudinal CT study. (22726962)
2012
9
Variations in management of mild prenatal hydronephrosis among maternal-fetal medicine obstetricians, and pediatric urologists and radiologists. (22999539)
2012
10
Bedside renal ultrasonography: other utilities than hydronephrosis. (21748458)
2012
11
Giant seminal vesicle cyst causing ipsilateral hydronephrosis with contralateral renal agenesis. (21762968)
2012
12
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. (22430074)
2012
13
Risk factors associated with chronic kidney disease in patients with posterior urethral valves without prenatal hydronephrosis. (21527193)
2011
14
Postnatal evaluation and outcome of infants with antenatal hydronephrosis. (22649872)
2011
15
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
16
Renal pelvic diameters in human fetuses: anatomical reference for diagnosis of fetal hydronephrosis. (20947142)
2011
17
Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. (21460193)
2011
18
Interferon-I^ improves renal interstitial fibrosis and decreases intrarenal vascular resistance of hydronephrosis in an animal model. (21216449)
2011
19
End-stage renal disease due to hydronephrosis in a patient with artificial urinary sphincter. (22183524)
2011
20
Retroperitoneoscopic nephrectomy for symptomatic hydronephrosis using a SAND balloon catheter. (21745100)
2011
21
Unusually rapid growth of bilateral endometriomas and acute bilateral hydronephrosis. (21495801)
2011
22
Hydronephrosis in children with abdominal and pelvic neoplasms: outcome and survival analysis of a single center pediatric oncology series. (21855920)
2011
23
Molecular biology and nuclear medicine in pediatric hydronephrosis. (20823804)
2010
24
Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis? (20936157)
2010
25
Hydronephrosis caused by ureterosciatic herniation. (20350759)
2010
26
Calyceal plication with Anderson-Hynes pyeloplasty in a 7-year-old boy with giant hydronephrosis of a single right kidney. (19212938)
2009
27
Penicillin G-induced hemorrhagic cystitis with hydronephrosis. (19755771)
2009
28
Ascites, a new cause for bilateral hydronephrosis: case report. (19802498)
2009
29
Bladder tumour diagnosed in a case presenting with uterine leiomyoma and hydronephrosis. (19603338)
2009
30
Retroperitoneal leiomyomata as a cause of bilateral hydronephrosis and lumbosciatic pain. (22162734)
2009
31
Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. (18071685)
2008
32
Imaging kidney in conscious rats with high-frequency ultrasound and detection of two cases of unilateral congenital hydronephrosis. (17188800)
2007
33
Hydronephrosis as a prognostic marker in bladder cancer in a cystectomy-only series. (16904815)
2007
34
Outcome of isolated antenatal hydronephrosis: a prospective cohort study. (17653772)
2007
35
MA1llerianosis of ureter: a rare cause of hydronephrosis. (17572222)
2007
36
Breast carcinoma metastasizing to the urinary bladder presenting as bilateral hydronephrosis treated with ureteral stenting and chemotherapy. (17483026)
2007
37
Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux. (16967282)
2007
38
Conservative treatment of ureteropelvic junction obstruction in children with antenatal diagnosis of hydronephrosis: lessons learned after 16 years of follow-up. (16504374)
2006
39
Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. (16923965)
2006
40
Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis]. (16308433)
2005
41
Selective decrease in urinary aquaporin 2 and increase in prostaglandin E2 excretion is associated with postobstructive polyuria in human congenital hydronephrosis. (15466275)
2004
42
Down-regulation of inducible nitric oxide synthase (iNOS) in rat with congenital hydronephrosis. (14516401)
2003
43
Strategies for the Management of Exstrophy, Nonpalpable Testis, Hydronephrosis: Highlights From the Annual Meeting of the American Academy of Pediatrics Section on Urology October 9-12, 1999, Washington, DC. (16985737)
2000
44
Computed tomographic features of hydrocele 'en bisac' with hydronephrosis. (10444151)
1999
45
Hypertension and the renin-angiotensin system in the congenital hydronephrosis rat with non-obstructive pelviureteric junction abnormalities. (8788602)
1996
46
Ovarian cyst causing massive hydronephrosis: report of a case. (2082745)
1990
47
Giant congenital hydronephrosis and isolated tuberculous granulomatous pyelitis. (3585026)
1987
48
The prognosis of surgically treated congenital hydronephrosis after diagnosis in utero. (3903216)
1985
49
Correction of congenital hydronephrosis in utero IV: in utero decompression prevents renal dysplasia. (6520669)
1984
50
Management of the fetus with congenital hydronephrosis. (7161663)
1982

Variations for Hydronephrosis

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Expression for genes affiliated with Hydronephrosis

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Expression patterns in normal tissues for genes affiliated with Hydronephrosis

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Pathways for genes affiliated with Hydronephrosis

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Compounds for genes affiliated with Hydronephrosis

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Compounds related to Hydronephrosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1mercury449.9NAGLU, AQP2
2desmopressin44 61 28 1112.9NAGLU, AQP2
3furosemide44 61 28 50 24 1114.9AQP2, NAGLU
4lithium44 50 24 1112.9AQP2, NAGLU
55-aminolevulinic acid44 2410.9NAGLU, HMOX1
6isoflurane50 44 1111.9NAGLU, HMOX1
7deferoxamine44 1110.8NAGLU, HMOX1
8urea44 24 1111.8NAGLU, AQP2
9enalapril44 50 1111.8NAGLU, AGTR2
10nifedipine44 28 50 1112.7HMOX1, NAGLU
11losartan44 50 28 1112.7AGTR2, NAGLU
12citrate449.7NAGLU, HMOX1
13oltipraz449.6HMOX1, AHR
14tbhq449.6HMOX1, AHR
15cgmp44 2810.6AGTR2, HMOX1
16omeprazole44 50 28 24 1113.5HMOX1, AHR
17sulforaphane449.5HMOX1, AHR
18leptomycin b44 6110.5HMOX1, AHR
19phenobarbital44 28 50 1112.5HMOX1, AHR
20atorvastatin44 50 28 24 1113.5AHR, HMOX1
21resveratrol44 61 24 1112.5HMOX1, AHR
22egcg449.4AHR, HMOX1
23prostaglandin449.4AQP2, AGTR2
24nacl449.4AGTR2, AQP2
25prostacyclin449.4AGTR2, HMOX1
26mg 13244 6110.4HMOX1, AHR
27cisplatin44 50 61 1112.4HMOX1, NAGLU, AQP2
28quercetin44 61 24 1112.3HMOX1, AHR
29Water249.3HMOX1, NAGLU, AQP2
30carbon449.3AHR, HMOX1
31curcumin449.3HMOX1, AHR
32sodium44 2410.3AGTR2, NAGLU, AQP2
33creatinine449.3AQP2, NAGLU, AGTR2
34arsenite44 2410.2HMOX1, AHR
35nadph44 2410.2NAGLU, HMOX1, AGTR2
36superoxide44 2410.2AGTR2, HMOX1, NAGLU
37glycerol44 24 1111.1AQP2, AHR
38oxygen44 2410.1AGTR2, HMOX1, NAGLU
39pge2449.1HMOX1, AQP2, AHR
40n acetylcysteine449.0AHR, NAGLU, HMOX1
41steroid449.0NAGLU, AQP2, AHR
42dexamethasone44 50 28 1112.0AHR, AQP2, HMOX1
43dmso448.9AQP2, AHR
44cycloheximide448.9AGTR2, HMOX1, AHR
45cyclosporin a44 28 6110.8AQP2, NAGLU, HMOX1, AGTR2
46nitric oxide44 24 1110.8AQP2, NAGLU, HMOX1, AGTR2
47estrogen448.8AGTR2, HMOX1, AHR
48cysteine448.6HMOX1, NAGLU, AQP2, AHR
49arginine448.5AGTR2, HMOX1, AQP2, AHR
50alanine448.0AGTR2, HMOX1, NAGLU, AQP2, AHR

GO Terms for genes affiliated with Hydronephrosis

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Cellular components related to Hydronephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.5NAGLU, AQP2

Biological processes related to Hydronephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.3AGTR2, HMOX1
2positive regulation of vasodilationGO:0459099.2AGTR2, HMOX1
3excretionGO:0075889.2HMOX1, AQP2

Products for genes affiliated with Hydronephrosis

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  • Antibodies
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Sources for Hydronephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet