MCID: HYD002
MIFTS: 48

Hydronephrosis malady

Summaries for Hydronephrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hydronephrosis — literally \"water inside the kidney\" — refers to distension and dilation of the... more...

MalaCards: Hydronephrosis, also known as hydronephrosis nos, is related to ureteral obstruction and hypertension. An important gene associated with Hydronephrosis is AQP2 (aquaporin 2 (collecting duct)), and among its related pathways is Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds iopentol and p-aminohippuric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, testis and spinal cord, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Hydronephrosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

hydronephrosis 8 10 44 60
hydronephrosis nos 8


External Ids:

Disease Ontology8 DOID:11111
NCIt39 C26796
ICD9CM27 591
MeSH34 D006869

Related Diseases for Hydronephrosis

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17GeneCards, 18GeneDecks
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Diseases in the Congenital Hydronephrosis family:

hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1ureteral obstruction30.5CLU, AMBP
2hypertension30.4MME
3pyelonephritis30.4AMBP, B2M, NAGLU
4vesicoureteral reflux30.4AMBP, UPK1B, UPK3A, AGTR2, NAGLU, PLEKHF1
5nephrogenic diabetes insipidus30.3SLC12A1, AQP2
6urinary tract obstruction30.1AQP2
7renal agenesis30.1AGTR2
8chronic pyelonephritis30.1B2M, NAGLU
9transitional cell carcinoma30.0UPK1B
10peritonitis30.0B2M
11bladder carcinoma29.8UPK3A, CLU
12diabetes insipidus10.2
13urofacial syndrome10.2
14actinomycosis10.2
15urethritis10.1
16endometriosis10.1
17hydrocele10.1
18renal hypertension10.1
19tuberculosis10.1
20urethral obstruction10.1
21vaginitis10.1
22okamoto syndrome10.1
23multicystic renal dysplasia, bilateral10.1
24congenital hydronephrosis10.1
25wegener's granulomatosis10.0
26ureterocele10.0
27polyhydramnios10.0
28leiomyoma10.0
29pancreatitis10.0
30megacystis microcolon intestinal hypoperistalsis syndrome10.0
31coloboma porencephaly hydronephrosis10.0
32primary hyperoxaluria10.0AMBP
33kidney cancer10.0ZNF135
34ovarian brenner tumor10.0UPK3A
35congestive heart failure10.0MME
36acute myocardial infarction10.0CLU, NAGLU
37fallopian tube cancer10.0B2M, NAGLU
38urinary system disease10.0B2M, NAGLU
39lymphomatoid papulosis10.0CLU
40acute kidney failure10.0AMBP, B2M, NAGLU
41dementia10.0CLU, AMBP
42metabolic acidosis10.0B2M, SLC12A1, AQP2
43essential hypertension10.0AGTR2, NAGLU, MME, SLC12A1, AQP2
44hypertrophy of breast10.0ID2, AGTR2, AHR, CLU
45ischemia10.0MME, CLU, NAGLU, AGTR2
46diabetic nephropathy10.0AMBP, B2M, AGTR2, NAGLU, AQP2
47liver cirrhosis10.0AQP2, ID2
48nephrotic syndrome10.0CLU, NAGLU, B2M, AMBP
49proteinuria10.0AMBP, B2M, AGTR2, NAGLU, CLU
50cystic fibrosis10.0AMBP, MME, AQP2

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to hydronephrosis

Clinical Features for Hydronephrosis

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Drugs & Therapeutics for Hydronephrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hydronephrosis

Drug clinical trials:

Search ClinicalTrials for Hydronephrosis

Search NIH Clinical Center for Hydronephrosis

Search CenterWatch for Hydronephrosis

Genetic Tests for Hydronephrosis

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Anatomical Context for Hydronephrosis

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32MalaCards
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MalaCards organs/tissues related to Hydronephrosis:

32
Kidney, Testis, Spinal cord, Cervix, Breast, Uterus, Colon, Smooth muscle, Heart, B cells, Monocytes, Fetal lung, Testes, Prostate, Bone, Pancreas, Lung, Pituitary

Animal Models for Hydronephrosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hydronephrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.4ID2, B2M, AGTR2, AHR, ACD, ZIC3
2MP:00053899.1ZIC3, AMBP, ID2, B2M, AHR, SLC12A1
3MP:00053858.9ZIC3, B2M, TBX18, AGTR2, AHR, NAGLU
4MP:00053788.9ZIC3, ID2, B2M, TBX18, AGTR2, AHR
5MP:00053678.7AQP2, ID2, UPK3A, TBX18, AGTR2, AHR
6MP:00053868.7ZIC3, AMBP, ID2, AGTR2, NAGLU, SLC12A1
7MP:00107718.6AGTR2, TBX18, B2M, ID2, AHR, NAGLU
8MP:00107688.5TBX18, B2M, ID2, ZIC3, AGTR2, AHR

Publications for Hydronephrosis

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50PubMed
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Articles related to Hydronephrosis:

(show top 50)    (show all 659)
idTitleAuthorsYear
1
Dyspnea as an unexpected presentation of huge hydronephrosis. (24413716)
2014
2
Rare case of atrophic ectopic kidney with giant hydronephrosis in a 7-year-old girl. (23290143)
2013
3
Urinary proteome analysis in congenital bilateral hydronephrosis. (22891811)
2013
4
Evaluations for hydronephrosis after the establishment of tubeless cutaneous ureterostomy. (23526413)
2013
5
Prospective evaluation of intra-observer variability of the hydronephrosis index in sonographic examination of 44 patients with acute renal colic. (23793577)
2013
6
Correlation of volume, position of stone, and hydronephrosis with microhematuria in patients with solitary urolithiasis. (23612123)
2013
7
Reply from authors re: Brian R. Matlaga. How do we manage infected, obstructed hydronephrosis? Eur Urol 2013;64:93-4: the infected upper urinary tract stone and obstruction: stent first where possible? (23159453)
2013
8
Revised guidelines on management of antenatal hydronephrosis. (23474928)
2013
9
Giant seminal vesicle cyst causing ipsilateral hydronephrosis with contralateral renal agenesis. (21762968)
2012
10
Response to: Hydronephrosis due to pelviureteric junction narrowing: Utility of urinary enzymes to predict the need for surgical management and follow up. (22529566)
2012
11
The role of ultrasound in predicting surgical intervention for prenatal hydronephrosis. (22425099)
2012
12
Unilateral hydronephrosis and hydroureter by foreign body in urinary bladder: a case report. (22690106)
2012
13
Masked hydronephrosis. (22707903)
2012
14
Giant hydronephrosis. (21367793)
2011
15
Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis. (21220211)
2011
16
Retroperitoneal Castleman's disease presenting with hydronephrosis indistinguishable from lymphoma. (21501323)
2011
17
Colossal hydronephrosis caused by pelvi-ureteric junction obstruction. (22674605)
2011
18
Surgical management of inferior vena cava strut penetration causing hydronephrosis: case report. (20843969)
2010
19
Giant hydroureteronephrosis associated with ipsilateral inguinal hernia and contralateral hydronephrosis: a case study. (21232186)
2010
20
Puerperal ovarian vein thrombosis presenting as rt loin pain and hydronephrosis: report of 2 cases. (22043362)
2010
21
Management of patients with huge pelvic actinomycosis complicated with hydronephrosis: a case report. (21075712)
2010
22
Postnatal outcome of fetal hydronephrosis: implications for prenatal counselling. (20535287)
2010
23
Can the degree of hydronephrosis on ultrasound predict kidney stone size? (20837260)
2010
24
Unilateral hydronephrosis and partial ureteral obstruction by entrapment in a granuloma in a spayed dog. (19887389)
2009
25
Delayed diagnosis of ureteral obstruction and hydronephrosis despite intraoperative cystoscopy: a case report. (18567284)
2008
26
Outcome of isolated antenatal hydronephrosis: a prospective cohort study. (17653772)
2007
27
Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux. (16967282)
2007
28
Can suppressive antibiotics be avoided in the postnatal management of antenatally detected obstructive hydronephrosis? (19718352)
2007
29
End cutaneous ureterostomy for the management of severe hydronephrosis. (17382764)
2007
30
Hydronephrosis during pregnancy. (17499674)
2007
31
Magnetic resonance urography in the evaluation of prenatally diagnosed hydronephrosis and renal dysgenesis. (16945650)
2006
32
Successful renal transcatheter arterial embolization in three patients with symptomatic hydronephrosis due to ureteral obstruction. (16847366)
2006
33
Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis. (16232194)
2005
34
Nephrogenic diabetes insipidus due to hydronephrosis in a patient with a solitary kidney. (14586722)
2003
35
Protein-losing enteropathy in a young African-American woman with abdominal pain, diarrhea and hydronephrosis. (11787872)
2001
36
Cystic rectal duplication: a rare cause of neonatal bladder-outlet obstruction and hydronephrosis. (11315295)
2001
37
49,XXXXY syndrome with hydronephrosis caused by intravesical ureterocele. (10799004)
1999
38
Two brothers with varying combinations of severe developmental delay, epilepsy, microcephaly, tetralogy of Fallot and hydronephrosis. (10327246)
1999
39
Hypertension and the renin-angiotensin system in the congenital hydronephrosis rat with non-obstructive pelviureteric junction abnormalities. (8788602)
1996
40
A major renal artery aneurysm as the cause of a hydronephrosis with renovascular hypertension. (8961495)
1996
41
Duration and severity of congenital hydronephrosis as a cause of smooth muscle deterioration in pyelo-ureteral junction obstruction. (2284874)
1990
42
Giant congenital hydronephrosis and isolated tuberculous granulomatous pyelitis. (3585026)
1987
43
Cerebral gigantism with hydronephrosis: a case report. (3955872)
1986
44
Cis-platinum therapy in a patient with extragonadal seminoma and hydronephrosis of the only functioning kidney. A case report. (2424104)
1986
45
Fetal surgery for congenital hydronephrosis. (3897489)
1985
46
Re: the urographic findings in acute pyelonephritis: non-obstructive hydronephrosis. (850330)
1977
47
Congenital hydronephrosis of lower segment in duplex kidney. (1274004)
1976
48
The management of congenital hydronephrosis in the newborn. (4637092)
1972
49
Effect of congenital hydronephrosis on experimental pyelonephritis. (4963691)
1966
50
Congenital Hydronephrosis of both Kidneys; both Ureters dilated, with Hypertrophy of Bladder. (19979448)
1916

Genetic Variations for Hydronephrosis

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Expression for genes affiliated with Hydronephrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hydronephrosis

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Pathways for genes affiliated with Hydronephrosis

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49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Hydronephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1MME, AGTR2

Compounds for genes affiliated with Hydronephrosis

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Hydronephrosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1iopentol4410.5B2M, NAGLU
2p-aminohippuric acid4410.5B2M, NAGLU
3tobramycin4410.5B2M, NAGLU
4fosfomycin4410.5B2M, NAGLU
5mesna4410.5NAGLU, B2M
6aluminium44 1111.4NAGLU, B2M
7desmopressin44 59 28 1113.4AQP2, NAGLU, B2M
8mercury4410.3AQP2, NAGLU, AMBP
9captopril44 28 49 59 1114.3MME, AGTR2, B2M
1099mtc-dmsa4410.3AMBP, B2M, NAGLU
11amikacin4410.3AMBP, B2M, NAGLU
12dmsa4410.3AMBP, B2M, NAGLU
13iohexol4410.3AMBP, B2M, NAGLU
14hanp4410.3AMBP, B2M
15furosemide44 49 59 28 11 2415.3AQP2, SLC12A1, MME, NAGLU
16ifosfamide44 1111.3NAGLU, B2M, AMBP
17calcium oxalate4410.2NAGLU, AMBP
18enalapril44 49 1112.2AMBP, AGTR2, NAGLU, MME
19cadmium44 2411.2NAGLU, B2M, AMBP
20inulin4410.1CLU, NAGLU, B2M, AMBP
21aprotinin44 1111.1MME, NAGLU, AMBP
22prostaglandin4410.1AQP2, MME, AGTR2, AMBP
23lead4410.1AMBP, B2M, NAGLU, MME
24trichloroethylene4410.1AMBP, NAGLU
25vitamin-e4410.1B2M, NAGLU, MME
26uric acid44 2411.1NAGLU, B2M, AMBP
27chloride4410.0B2M, CLU, MME, SLC12A1, AQP2
28vitamin a44 11 2412.0MME, NAGLU, B2M, AMBP
29pge24410.0B2M, AHR, MME, SLC12A1, AQP2
30urea44 11 2412.0AMBP, B2M, NAGLU, SLC12A1, AQP2
31ulinastatin4410.0AMBP, NAGLU
32potassium44 11 2412.0AMBP, NAGLU, MME, SLC12A1, AQP2
33cycloheximide449.9B2M, AGTR2, AHR, CLU, MME
34cisplatin44 49 59 1112.9AMBP, B2M, NAGLU, CLU, AQP2
35vitamin d449.9CLU, NAGLU, AHR, B2M
36lactate449.8AMBP, B2M, NAGLU, CLU, MME
37cyclosporin a44 28 5911.8AMBP, B2M, AGTR2, NAGLU, MME, AQP2
38creatinine449.8AMBP, B2M, AGTR2, NAGLU, MME, AQP2
39alanine449.7AMBP, B2M, AGTR2, AHR, NAGLU, AQP2
40sodium44 2410.7AMBP, B2M, AGTR2, NAGLU, MME, SLC12A1
41estrogen449.7ID2, B2M, AGTR2, AHR, CLU, MME
42steroid449.6AMBP, B2M, AHR, NAGLU, CLU, MME
43dexamethasone44 49 28 1112.6AQP2, MME, CLU, AHR, ID2
44cysteine449.6AMBP, B2M, AHR, NAGLU, CLU, MME
45retinoic acid44 2410.5AMBP, ID2, B2M, AHR, CLU, MME
46calcium44 49 11 2411.8AMBP, B2M, AGTR2, NAGLU, CLU, MME

GO Terms for genes affiliated with Hydronephrosis

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Products for genes affiliated with Hydronephrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hydronephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet