MCID: HYD002
MIFTS: 53

Hydronephrosis malady

Nephrological diseases, Fetal diseases, Rare diseases categories

Summaries for Hydronephrosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hydronephrosis ? literally \"water inside the kidney\" ? refers to distension and dilation of the renal... more...

MalaCards: Hydronephrosis, also known as hydronephrosis nos, is related to vesicoureteral reflux and renal agenesis. An important gene associated with Hydronephrosis is AQP2 (aquaporin 2 (collecting duct)). The compounds mercury and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testis and spinal cord, and related mouse phenotypes are liver/biliary system and muscle.

Aliases & Classifications for Hydronephrosis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

hydronephrosis 9 11 46 63
hydronephrosis nos 9


External Ids:

Disease Ontology9 DOID:11111
NCIt41 C26796
MeSH36 D006869
ICD9CM28 591

Related Diseases for Hydronephrosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Congenital Hydronephrosis family:

hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1vesicoureteral reflux30.5AGTR2, NAGLU
2renal agenesis30.2AGTR2
3acute pyelonephritis30.1NAGLU
4breast cancer29.5AHR, NAGLU, AGTR2, HMOX1
5congenital hydronephrosis10.8
6horseshoe kidney10.3
7ureteral obstruction10.3
8hypertension10.3
9pyelonephritis10.3
10diabetes insipidus10.2
11urofacial syndrome10.2
12actinomycosis10.2
13nephrogenic diabetes insipidus10.2
14aneurysm10.2
15urethritis10.1
16endometriosis10.1
17chronic pyelonephritis10.1
18hydrocele10.1
19tuberculosis10.1
20urethral obstruction10.1
21vaginitis10.1
22multicystic renal dysplasia, bilateral10.1
23okamoto syndrome10.1
24retroperitoneal fibrosis10.1
25schinzel giedion syndrome10.1
26ureterocele10.0
27polyhydramnios10.0
28leiomyoma10.0
29pancreatitis10.0
30peritonitis10.0
31transitional cell carcinoma10.0
32urinary tract obstruction10.0
33coloboma porencephaly hydronephrosis10.0
34megacystis microcolon intestinal hypoperistalsis syndrome10.0
35spinal cord injury10.0
36renal dysplasia10.0
37congenital heart disease10.0AGTR2, HMOX1
38chronic kidney failure10.0AQP2, NAGLU, HMOX1
39essential hypertension10.0AGTR2, NAGLU, AQP2
40diabetic nephropathy10.0AQP2, NAGLU, AGTR2
41pneumonia10.0HMOX1, NAGLU
42lung adenocarcinoma10.0HMOX1, AHR
43mental retardation10.0AQP2, AGTR2, NAGLU
44proteinuria10.0AGTR2, NAGLU, HMOX1
45ischemia10.0NAGLU, AGTR2, HMOX1
46anuria10.0
47nephrolithiasis10.0
48renal tuberculosis10.0
49duodenitis10.0
50erdheim-chester disease10.0

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to hydronephrosis

Symptoms for Hydronephrosis

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Drugs & Therapeutics for Hydronephrosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hydronephrosis

Drug clinical trials:

Search ClinicalTrials for Hydronephrosis

Search NIH Clinical Center for Hydronephrosis

Search CenterWatch for Hydronephrosis

Genetic Tests for Hydronephrosis

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Anatomical Context for Hydronephrosis

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34MalaCards
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MalaCards organs/tissues related to Hydronephrosis:

34
Kidney, Testis, Spinal cord, Cervix, Breast, Uterus, Colon, Smooth muscle, Heart, B cells, Monocytes, Fetal lung, Testes, Prostate, Bone, Pancreas, Lung, Pituitary

Animal Models for Hydronephrosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hydronephrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5AHR, NAGLU, HMOX1
2MP:00053698.5AGTR2, HMOX1, AHR
3MP:00107718.2AHR, AQP2, NAGLU, AGTR2
4MP:00053978.2HMOX1, NAGLU, AQP2, AHR
5MP:00053858.1AHR, NAGLU, HMOX1, AGTR2
6MP:00053767.8AGTR2, HMOX1, AQP2, AHR
7MP:00053677.8AGTR2, HMOX1, NAGLU, AQP2, AHR
8MP:00053867.7AHR, AQP2, NAGLU, HMOX1, AGTR2
9MP:00053787.7AHR, AQP2, NAGLU, HMOX1, AGTR2
10MP:00107687.7AGTR2, HMOX1, NAGLU, AQP2, AHR

Publications for Hydronephrosis

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53PubMed
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Articles related to Hydronephrosis:

(show top 50)    (show all 653)
idTitleAuthorsYear
1
Variability in Use of Voiding Cystourethrogram During Initial Evaluation of Infants With Congenital Hydronephrosis. (24397941)
2014
2
Elevation of Ca 125 in a patient with giant congenital hydronephrosis]. (23589602)
2013
3
Rare case of atrophic ectopic kidney with giant hydronephrosis in a 7-year-old girl. (23290143)
2013
4
Laparoscopic Anderson-Hynes pyeloplasty without symphysiotomy for hydronephrosis with horseshoe kidney. (23710906)
2013
5
Giant Urinary Bladder and Bilateral Giant Hydronephrosis due to Bladder Neck Obstruction: One Case Report and Literature Review. (22606637)
2012
6
Frequency and etiology of unexplained bilateral hydronephrosis in patients with breast cancer: results of a longitudinal CT study. (22726962)
2012
7
Variations in management of mild prenatal hydronephrosis among maternal-fetal medicine obstetricians, and pediatric urologists and radiologists. (22999539)
2012
8
Bedside renal ultrasonography: other utilities than hydronephrosis. (21748458)
2012
9
Giant seminal vesicle cyst causing ipsilateral hydronephrosis with contralateral renal agenesis. (21762968)
2012
10
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. (22430074)
2012
11
Postnatal evaluation and outcome of infants with antenatal hydronephrosis. (22649872)
2011
12
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
13
Renal pelvic diameters in human fetuses: anatomical reference for diagnosis of fetal hydronephrosis. (20947142)
2011
14
Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. (21460193)
2011
15
Interferon-I^ improves renal interstitial fibrosis and decreases intrarenal vascular resistance of hydronephrosis in an animal model. (21216449)
2011
16
End-stage renal disease due to hydronephrosis in a patient with artificial urinary sphincter. (22183524)
2011
17
Retroperitoneoscopic nephrectomy for symptomatic hydronephrosis using a SAND balloon catheter. (21745100)
2011
18
Unusually rapid growth of bilateral endometriomas and acute bilateral hydronephrosis. (21495801)
2011
19
Hydronephrosis in children with abdominal and pelvic neoplasms: outcome and survival analysis of a single center pediatric oncology series. (21855920)
2011
20
Molecular biology and nuclear medicine in pediatric hydronephrosis. (20823804)
2010
21
Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis? (20936157)
2010
22
Hydronephrosis caused by ureterosciatic herniation. (20350759)
2010
23
Calyceal plication with Anderson-Hynes pyeloplasty in a 7-year-old boy with giant hydronephrosis of a single right kidney. (19212938)
2009
24
Penicillin G-induced hemorrhagic cystitis with hydronephrosis. (19755771)
2009
25
Ascites, a new cause for bilateral hydronephrosis: case report. (19802498)
2009
26
Bladder tumour diagnosed in a case presenting with uterine leiomyoma and hydronephrosis. (19603338)
2009
27
Retroperitoneal leiomyomata as a cause of bilateral hydronephrosis and lumbosciatic pain. (22162734)
2009
28
Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. (18071685)
2008
29
Imaging kidney in conscious rats with high-frequency ultrasound and detection of two cases of unilateral congenital hydronephrosis. (17188800)
2007
30
Hydronephrosis as a prognostic marker in bladder cancer in a cystectomy-only series. (16904815)
2007
31
Outcome of isolated antenatal hydronephrosis: a prospective cohort study. (17653772)
2007
32
MA1llerianosis of ureter: a rare cause of hydronephrosis. (17572222)
2007
33
Breast carcinoma metastasizing to the urinary bladder presenting as bilateral hydronephrosis treated with ureteral stenting and chemotherapy. (17483026)
2007
34
Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux. (16967282)
2007
35
Conservative treatment of ureteropelvic junction obstruction in children with antenatal diagnosis of hydronephrosis: lessons learned after 16 years of follow-up. (16504374)
2006
36
Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. (16923965)
2006
37
Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis]. (16308433)
2005
38
Selective decrease in urinary aquaporin 2 and increase in prostaglandin E2 excretion is associated with postobstructive polyuria in human congenital hydronephrosis. (15466275)
2004
39
Down-regulation of inducible nitric oxide synthase (iNOS) in rat with congenital hydronephrosis. (14516401)
2003
40
Spontaneous regression of bilateral hydronephrosis due to retroperitoneal fibrosis. (11487086)
2001
41
Strategies for the Management of Exstrophy, Nonpalpable Testis, Hydronephrosis: Highlights From the Annual Meeting of the American Academy of Pediatrics Section on Urology October 9-12, 1999, Washington, DC. (16985737)
2000
42
Computed tomographic features of hydrocele 'en bisac' with hydronephrosis. (10444151)
1999
43
Hypertension and the renin-angiotensin system in the congenital hydronephrosis rat with non-obstructive pelviureteric junction abnormalities. (8788602)
1996
44
Ovarian cyst causing massive hydronephrosis: report of a case. (2082745)
1990
45
Giant congenital hydronephrosis and isolated tuberculous granulomatous pyelitis. (3585026)
1987
46
The prognosis of surgically treated congenital hydronephrosis after diagnosis in utero. (3903216)
1985
47
Correction of congenital hydronephrosis in utero IV: in utero decompression prevents renal dysplasia. (6520669)
1984
48
Management of the fetus with congenital hydronephrosis. (7161663)
1982
49
A clinical and histological study on congenital hydronephrosis with special reference to hypertension. (6073285)
1967
50
Duodenal obstruction caused by chronic pyelonephritis and hydronephrosis. (21014787)
1946

Variations for Hydronephrosis

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Expression for genes affiliated with Hydronephrosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hydronephrosis

Search GEO for disease gene expression data for Hydronephrosis.

Pathways for genes affiliated with Hydronephrosis

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Compounds for genes affiliated with Hydronephrosis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Hydronephrosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1mercury469.9NAGLU, AQP2
2desmopressin46 62 30 1212.9NAGLU, AQP2
3furosemide46 62 30 52 25 1214.9AQP2, NAGLU
4lithium46 52 25 1212.9AQP2, NAGLU
55-aminolevulinic acid46 2510.9NAGLU, HMOX1
6isoflurane52 46 1211.9NAGLU, HMOX1
7deferoxamine46 1210.8NAGLU, HMOX1
8urea46 25 1211.8NAGLU, AQP2
9enalapril46 52 1211.8NAGLU, AGTR2
10nifedipine46 30 52 1212.7HMOX1, NAGLU
11losartan46 52 30 1212.7AGTR2, NAGLU
12citrate469.7NAGLU, HMOX1
13oltipraz469.6HMOX1, AHR
14tbhq469.6HMOX1, AHR
15cgmp46 3010.6AGTR2, HMOX1
16omeprazole46 52 30 25 1213.5HMOX1, AHR
17sulforaphane469.5HMOX1, AHR
18leptomycin b46 6210.5HMOX1, AHR
19phenobarbital46 30 52 1212.5HMOX1, AHR
20atorvastatin46 52 30 25 1213.5AHR, HMOX1
21resveratrol46 62 25 1212.5HMOX1, AHR
22egcg469.4AHR, HMOX1
23prostaglandin469.4AQP2, AGTR2
24nacl469.4AGTR2, AQP2
25prostacyclin469.4AGTR2, HMOX1
26mg 13246 6210.4HMOX1, AHR
27cisplatin46 52 62 1212.4HMOX1, NAGLU, AQP2
28quercetin46 62 25 1212.3HMOX1, AHR
29Water259.3HMOX1, NAGLU, AQP2
30carbon469.3AHR, HMOX1
31curcumin469.3HMOX1, AHR
32sodium46 2510.3AGTR2, NAGLU, AQP2
33creatinine469.3AQP2, NAGLU, AGTR2
34arsenite46 2510.2HMOX1, AHR
35nadph46 2510.2NAGLU, HMOX1, AGTR2
36superoxide46 2510.2AGTR2, HMOX1, NAGLU
37glycerol46 25 1211.1AQP2, AHR
38oxygen46 2510.1AGTR2, HMOX1, NAGLU
39pge2469.1HMOX1, AQP2, AHR
40n acetylcysteine469.0AHR, NAGLU, HMOX1
41steroid469.0NAGLU, AQP2, AHR
42dexamethasone46 52 30 1212.0AHR, AQP2, HMOX1
43dmso468.9AQP2, AHR
44cycloheximide468.9AGTR2, HMOX1, AHR
45cyclosporin a46 30 6210.8AQP2, NAGLU, HMOX1, AGTR2
46nitric oxide46 25 1210.8AQP2, NAGLU, HMOX1, AGTR2
47estrogen468.8AGTR2, HMOX1, AHR
48cysteine468.6HMOX1, NAGLU, AQP2, AHR
49arginine468.5AGTR2, HMOX1, AQP2, AHR
50alanine468.0AGTR2, HMOX1, NAGLU, AQP2, AHR

GO Terms for genes affiliated with Hydronephrosis

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17Gene Ontology
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Cellular components related to Hydronephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.5NAGLU, AQP2

Biological processes related to Hydronephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.3AGTR2, HMOX1
2positive regulation of vasodilationGO:0459099.2AGTR2, HMOX1
3excretionGO:0075889.2HMOX1, AQP2

Products for genes affiliated with Hydronephrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hydronephrosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet