MCID: HYD002
MIFTS: 45

Hydronephrosis malady

Nephrological diseases, Fetal diseases, Rare diseases categories

Summaries for Hydronephrosis

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Wikipedia:63 Hydronephrosis ? literally \"water inside the kidney\" ? refers to distension and dilation of the renal... more...

MalaCards based summary: Hydronephrosis is related to vesicoureteral reflux and acute pyelonephritis. An important gene associated with Hydronephrosis is AQP2 (aquaporin 2 (collecting duct)). The compounds mercury and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, spinal cord and testis, and related mouse phenotypes are liver/biliary system and muscle.

Aliases & Classifications for Hydronephrosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 27ICD9CM
See all sources

Hydronephrosis, Aliases & Descriptions:

Name: Hydronephrosis 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:11111
NCIt38 C26796
MeSH33 D006869
ICD9CM27 591

Related Diseases for Hydronephrosis

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Diseases in the Hydronephrosis family:

Congenital Hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 326)
idRelated DiseaseScoreTop Affiliating Genes
1vesicoureteral reflux30.6AGTR2, NAGLU
2acute pyelonephritis30.5NAGLU
3breast cancer28.8AHR, NAGLU, AGTR2, HMOX1
4congenital hydronephrosis10.8
5pyelonephritis10.4
6ureteral obstruction10.3
7horseshoe kidney10.3
8urofacial syndrome 110.3
9renal hypodysplasia/aplasia 110.3AGTR2
10urethritis10.2
11actinomycosis10.2
12diabetes insipidus10.2
13endometriosis10.2
14visceral myopathy10.2
15pelviureteric junction obstruction10.2
16spinal cord injury10.2
17hydrocele10.2
18retroperitoneal fibrosis10.2
19aneurysm10.2
20chronic pyelonephritis10.1
21cystitis10.1
22tuberculosis10.1
23urethral obstruction10.1
24vaginitis10.1
25coloboma porencephaly hydronephrosis10.1
26renal dysplasia10.1
27eagle-barrett syndrome10.0
28ureterocele10.0
29polyhydramnios10.0
30leiomyoma10.0
31pancreatitis10.0
32peritonitis10.0
33transitional cell carcinoma10.0
34urinary tract obstruction10.0
35okamoto syndrome10.0
36schinzel giedion syndrome10.0
37congenital heart disease10.0AGTR2, HMOX1
38peters anomaly10.0
39robinow syndrome, autosomal dominant10.0
40coffin-siris syndrome10.0
41mesomelia-synostoses syndrome10.0
42nijmegen breakage syndrome10.0
43ritscher-schinzel syndrome10.0
44robinow syndrome, autosomal recessive10.0
45genitopatellar syndrome10.0
46smith-lemli-opitz syndrome10.0
47johanson-blizzard syndrome10.0
48koolen-de vries syndrome10.0
49campomelic dysplasia10.0
50mckusick-kaufman syndrome10.0

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to hydronephrosis

Symptoms for Hydronephrosis

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Drugs & Therapeutics for Hydronephrosis

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Drug clinical trials:

Search ClinicalTrials for Hydronephrosis

Search NIH Clinical Center for Hydronephrosis

Genetic Tests for Hydronephrosis

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Anatomical Context for Hydronephrosis

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MalaCards organs/tissues related to Hydronephrosis:

31
Kidney, Spinal cord, Testis, Breast, Cervix, Heart, Smooth muscle, Colon, Uterus, Prostate, Bone, Lung, Pancreas, Testes, Monocytes, B cells, Fetal lung, Pituitary

Animal Models for Hydronephrosis or affiliated genes

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MGI Mouse Phenotypes related to Hydronephrosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5NAGLU, HMOX1, AHR
2MP:00053698.5AHR, HMOX1, AGTR2
3MP:00107718.2AHR, AQP2, NAGLU, AGTR2
4MP:00053978.2HMOX1, AHR, AQP2, NAGLU
5MP:00053858.1HMOX1, NAGLU, AHR, AGTR2
6MP:00053767.8AQP2, AGTR2, HMOX1, AHR
7MP:00053677.8AHR, NAGLU, AQP2, HMOX1, AGTR2
8MP:00053867.7HMOX1, AQP2, NAGLU, AGTR2, AHR
9MP:00053787.7HMOX1, AHR, AQP2, NAGLU, AGTR2
10MP:00107687.7AGTR2, AHR, AQP2, NAGLU, HMOX1

Publications for Hydronephrosis

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Articles related to Hydronephrosis:

(show top 50)    (show all 691)
idTitleAuthorsYear
1
Variability in Use of Voiding Cystourethrogram During Initial Evaluation of Infants With Congenital Hydronephrosis. (24397941)
2014
2
Congenital hydronephrosis: disease or condition? (25532093)
2014
3
Congential lumbar hernia with malrotation of left kidney and hydronephrosis in an infant: a rare presentation. (25177616)
2014
4
Relationship between renal apparent diffusion coefficient values and glomerular filtration rate in infants with congenital hydronephrosis. (25382444)
2014
5
Elevation of Ca 125 in a patient with giant congenital hydronephrosis]. (23589602)
2013
6
Rare case of atrophic ectopic kidney with giant hydronephrosis in a 7-year-old girl. (23290143)
2013
7
Laparoscopic Anderson-Hynes pyeloplasty without symphysiotomy for hydronephrosis with horseshoe kidney. (23710906)
2013
8
Giant Urinary Bladder and Bilateral Giant Hydronephrosis due to Bladder Neck Obstruction: One Case Report and Literature Review. (22606637)
2012
9
Frequency and etiology of unexplained bilateral hydronephrosis in patients with breast cancer: results of a longitudinal CT study. (22726962)
2012
10
Variations in management of mild prenatal hydronephrosis among maternal-fetal medicine obstetricians, and pediatric urologists and radiologists. (22999539)
2012
11
Bedside renal ultrasonography: other utilities than hydronephrosis. (21748458)
2012
12
Giant seminal vesicle cyst causing ipsilateral hydronephrosis with contralateral renal agenesis. (21762968)
2012
13
Risk factors associated with chronic kidney disease in patients with posterior urethral valves without prenatal hydronephrosis. (21527193)
2011
14
Postnatal evaluation and outcome of infants with antenatal hydronephrosis. (22649872)
2011
15
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
16
Renal pelvic diameters in human fetuses: anatomical reference for diagnosis of fetal hydronephrosis. (20947142)
2011
17
Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. (21460193)
2011
18
Interferon-I^ improves renal interstitial fibrosis and decreases intrarenal vascular resistance of hydronephrosis in an animal model. (21216449)
2011
19
End-stage renal disease due to hydronephrosis in a patient with artificial urinary sphincter. (22183524)
2011
20
Retroperitoneoscopic nephrectomy for symptomatic hydronephrosis using a SAND balloon catheter. (21745100)
2011
21
Unusually rapid growth of bilateral endometriomas and acute bilateral hydronephrosis. (21495801)
2011
22
Hydronephrosis in children with abdominal and pelvic neoplasms: outcome and survival analysis of a single center pediatric oncology series. (21855920)
2011
23
Molecular biology and nuclear medicine in pediatric hydronephrosis. (20823804)
2010
24
Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis? (20936157)
2010
25
Calyceal plication with Anderson-Hynes pyeloplasty in a 7-year-old boy with giant hydronephrosis of a single right kidney. (19212938)
2009
26
Penicillin G-induced hemorrhagic cystitis with hydronephrosis. (19755771)
2009
27
Ascites, a new cause for bilateral hydronephrosis: case report. (19802498)
2009
28
Bladder tumour diagnosed in a case presenting with uterine leiomyoma and hydronephrosis. (19603338)
2009
29
Retroperitoneal leiomyomata as a cause of bilateral hydronephrosis and lumbosciatic pain. (22162734)
2009
30
Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. (18071685)
2008
31
Imaging kidney in conscious rats with high-frequency ultrasound and detection of two cases of unilateral congenital hydronephrosis. (17188800)
2007
32
Hydronephrosis as a prognostic marker in bladder cancer in a cystectomy-only series. (16904815)
2007
33
Outcome of isolated antenatal hydronephrosis: a prospective cohort study. (17653772)
2007
34
MA1llerianosis of ureter: a rare cause of hydronephrosis. (17572222)
2007
35
Breast carcinoma metastasizing to the urinary bladder presenting as bilateral hydronephrosis treated with ureteral stenting and chemotherapy. (17483026)
2007
36
Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux. (16967282)
2007
37
Conservative treatment of ureteropelvic junction obstruction in children with antenatal diagnosis of hydronephrosis: lessons learned after 16 years of follow-up. (16504374)
2006
38
Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. (16923965)
2006
39
Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis]. (16308433)
2005
40
Selective decrease in urinary aquaporin 2 and increase in prostaglandin E2 excretion is associated with postobstructive polyuria in human congenital hydronephrosis. (15466275)
2004
41
Down-regulation of inducible nitric oxide synthase (iNOS) in rat with congenital hydronephrosis. (14516401)
2003
42
Strategies for the Management of Exstrophy, Nonpalpable Testis, Hydronephrosis: Highlights From the Annual Meeting of the American Academy of Pediatrics Section on Urology October 9-12, 1999, Washington, DC. (16985737)
2000
43
Computed tomographic features of hydrocele 'en bisac' with hydronephrosis. (10444151)
1999
44
Hypertension and the renin-angiotensin system in the congenital hydronephrosis rat with non-obstructive pelviureteric junction abnormalities. (8788602)
1996
45
Ovarian cyst causing massive hydronephrosis: report of a case. (2082745)
1990
46
Giant congenital hydronephrosis and isolated tuberculous granulomatous pyelitis. (3585026)
1987
47
The prognosis of surgically treated congenital hydronephrosis after diagnosis in utero. (3903216)
1985
48
Correction of congenital hydronephrosis in utero IV: in utero decompression prevents renal dysplasia. (6520669)
1984
49
Management of the fetus with congenital hydronephrosis. (7161663)
1982
50
Duodenal obstruction caused by chronic pyelonephritis and hydronephrosis. (21014787)
1946

Variations for Hydronephrosis

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Expression for genes affiliated with Hydronephrosis

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Search GEO for disease gene expression data for Hydronephrosis.

Pathways for genes affiliated with Hydronephrosis

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Compounds for genes affiliated with Hydronephrosis

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Compounds related to Hydronephrosis according to GeneCards Suite gene sharing:

(show all 50)
idCompoundScoreTop Affiliating Genes
1mercury439.9NAGLU, AQP2
2desmopressin43 59 28 1212.9NAGLU, AQP2
3furosemide43 59 28 49 24 1214.9AQP2, NAGLU
4lithium43 49 24 1212.9AQP2, NAGLU
55-aminolevulinic acid43 2410.9NAGLU, HMOX1
6isoflurane49 43 1211.9NAGLU, HMOX1
7deferoxamine43 1210.8NAGLU, HMOX1
8urea43 24 1211.8NAGLU, AQP2
9enalapril43 49 1211.8NAGLU, AGTR2
10nifedipine43 28 49 1212.7HMOX1, NAGLU
11losartan43 49 28 1212.7AGTR2, NAGLU
12citrate439.7NAGLU, HMOX1
13oltipraz439.6HMOX1, AHR
14tbhq439.6HMOX1, AHR
15cgmp43 2810.6AGTR2, HMOX1
16omeprazole43 49 28 24 1213.5HMOX1, AHR
17sulforaphane439.5HMOX1, AHR
18leptomycin b43 5910.5HMOX1, AHR
19phenobarbital43 28 49 1212.5HMOX1, AHR
20atorvastatin43 49 28 24 1213.5AHR, HMOX1
21resveratrol43 59 24 1212.5HMOX1, AHR
22egcg439.4AHR, HMOX1
23prostaglandin439.4AQP2, AGTR2
24nacl439.4AGTR2, AQP2
25prostacyclin439.4AGTR2, HMOX1
26mg 13243 5910.4HMOX1, AHR
27cisplatin43 49 59 1212.4HMOX1, NAGLU, AQP2
28quercetin43 59 24 1212.3HMOX1, AHR
29Water249.3HMOX1, NAGLU, AQP2
30carbon439.3AHR, HMOX1
31curcumin439.3HMOX1, AHR
32sodium43 2410.3AGTR2, NAGLU, AQP2
33creatinine439.3AQP2, NAGLU, AGTR2
34arsenite43 2410.2HMOX1, AHR
35nadph43 2410.2NAGLU, HMOX1, AGTR2
36superoxide43 2410.2AGTR2, HMOX1, NAGLU
37glycerol43 24 1211.1AQP2, AHR
38oxygen43 2410.1AGTR2, HMOX1, NAGLU
39pge2439.1HMOX1, AQP2, AHR
40n acetylcysteine439.0AHR, NAGLU, HMOX1
41steroid439.0NAGLU, AQP2, AHR
42dexamethasone43 49 28 1212.0AHR, AQP2, HMOX1
43dmso438.9AQP2, AHR
44cycloheximide438.9AGTR2, HMOX1, AHR
45cyclosporin a43 28 5910.8AQP2, NAGLU, HMOX1, AGTR2
46nitric oxide43 24 1210.8AQP2, NAGLU, HMOX1, AGTR2
47estrogen438.8AGTR2, HMOX1, AHR
48cysteine438.6HMOX1, NAGLU, AQP2, AHR
49arginine438.5AGTR2, HMOX1, AQP2, AHR
50alanine438.0AGTR2, HMOX1, NAGLU, AQP2, AHR

GO Terms for genes affiliated with Hydronephrosis

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Cellular components related to Hydronephrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:00057649.5NAGLU, AQP2

Biological processes related to Hydronephrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00082179.3AGTR2, HMOX1
2positive regulation of vasodilationGO:00459099.2AGTR2, HMOX1
3excretionGO:00075889.2HMOX1, AQP2

Products for genes affiliated with Hydronephrosis

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Sources for Hydronephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet