Aliases & Classifications for Hydrophthalmos

Summaries for Hydrophthalmos

MalaCards based summary : Hydrophthalmos is related to juvenile glaucoma and glaucoma 3, primary congenital, a. An important gene associated with Hydrophthalmos is OPTN (Optineurin), and among its related pathways/superpathways is Heart Development. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye and testes, and related phenotype is vision/eye.

Related Diseases for Hydrophthalmos

Diseases related to Hydrophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 juvenile glaucoma 30.6 CYP1B1 FOXC1 OPTN PITX2
2 glaucoma 3, primary congenital, a 29.5 CYP1B1 FBXO7 FOXC1 LTBP2 OPTN PITX2
3 acrofrontofacionasal dysostosis 10.2 CYP1B1 OPTN
4 glaucoma 1, open angle, a 10.2 CYP1B1 OPTN
5 ritscher-schinzel syndrome 10.1 FOXC1 OPTN
6 early-onset glaucoma 10.1 CYP1B1 PITX2
7 panophthalmitis 10.1 FBXO7 OPTN
8 axenfeld-rieger syndrome, type 3 10.0 FOXC1 PITX2
9 primary angle-closure glaucoma 10.0 CYP1B1 OPTN
10 anterior segment dysgenesis 4 10.0 FOXC1 PITX2
11 intestinal atresia 10.0 FOXC1 PITX2
12 purulent endophthalmitis 10.0 FBXO7 OPTN
13 amblyopia 10.0 FBXO7 OPTN
14 persistent hyperplastic primary vitreous 9.9 FOXC1 PITX2
15 neurofibromatosis, type iv, of riccardi 9.9
16 cataract 9.9
17 myopia 9.9
18 glaucoma 3, primary infantile, b 9.9 CYP1B1 LTBP2
19 megalocornea 9.9 LTBP2 OPTN
20 glaucoma, primary open angle 9.9 CYP1B1 OPTN
21 corneal endothelial dystrophy 9.9 FBXO7 OPTN
22 phacogenic glaucoma 9.8 LTBP2 OPTN
23 axenfeld-rieger syndrome, type 2 9.8 FOXC1 OPTN PITX2
24 iris disease 9.8 FOXC1 OPTN PITX2
25 fuchs' endothelial dystrophy 9.7 FBXO7 PITX2
26 peters-plus syndrome 9.7 CYP1B1 FOXC1 PITX2
27 open-angle glaucoma 9.7 CYP1B1 OPTN
28 excessive tearing 9.6 CYP1B1 LTBP2 OPTN
29 intraocular pressure quantitative trait locus 9.5 CYP1B1 FOXC1 OPTN PITX2
30 axenfeld-rieger syndrome 9.4 CYP1B1 FOXC1 OPTN PITX2
31 aniridia 1 9.4 CYP1B1 FOXC1 OPTN PITX2
32 corneal edema 9.2 CYP1B1 FBXO7 LTBP2 OPTN
33 primary congenital glaucoma 8.8 CYP1B1 FOXC1 LTBP2 OPTN PITX2

Graphical network of the top 20 diseases related to Hydrophthalmos:



Diseases related to Hydrophthalmos

Symptoms & Phenotypes for Hydrophthalmos

MGI Mouse Phenotypes related to Hydrophthalmos:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 8.92 CYP1B1 FOXC1 LTBP2 PITX2

Drugs & Therapeutics for Hydrophthalmos

Drugs for Hydrophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
5
Timolol Approved Phase 3 26839-75-8 5478 33624
6
Travoprost Approved Phase 3,Phase 1 157283-68-6 5282226
7 tannic acid Approved, Nutraceutical Phase 3
8 Antihypertensive Agents Phase 3,Phase 2,Phase 1
9 Ophthalmic Solutions Phase 3,Phase 2,Phase 1,Early Phase 1
10 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
11 Adrenergic Agents Phase 3
12 Adrenergic Antagonists Phase 3
13 Adrenergic beta-Antagonists Phase 3
14 Anti-Arrhythmia Agents Phase 3
15 Neurotransmitter Agents Phase 3
16
Dorzolamide Approved Phase 2 120279-96-1 5284549 3154
17
Latanoprost Approved, Investigational Phase 2 130209-82-4 5311221 5282380
18 Carbonic Anhydrase Inhibitors Phase 2
19
Nitrous oxide Approved, Vet_approved Early Phase 1 10024-97-2 948
20
Sevoflurane Approved, Vet_approved Early Phase 1 28523-86-6 5206
21
Tetracaine Approved, Vet_approved Early Phase 1 94-24-6 5411
22
Menthol Approved 2216-51-5 16666
23 Analgesics Early Phase 1
24 Analgesics, Non-Narcotic Early Phase 1
25 Anesthetics Early Phase 1
26 Anesthetics, General Early Phase 1
27 Anesthetics, Inhalation Early Phase 1
28 Anesthetics, Local Early Phase 1
29 Central Nervous System Depressants Early Phase 1
30 Peripheral Nervous System Agents Early Phase 1
31 Platelet Aggregation Inhibitors Early Phase 1
32 Tetrahydrozoline Early Phase 1

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma Unknown status NCT01494974 Phase 4
2 Use of Bevacizumab in Trabeculectomy Surgery Completed NCT01166594 Phase 4 Bevacizumab;Control
3 Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients Completed NCT01652664 Phase 3 Travoprost 0.004% PQ ophthalmic solution;Timolol, 0.5% or 0.25% ophthalmic solution;Travoprost Vehicle
4 Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma Unknown status NCT01527682 Phase 2 Latanoprost, Dorzolamide
5 Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma Unknown status NCT02121171 Phase 1
6 Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma Unknown status NCT01460017 Phase 1
7 Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients Completed NCT01658839 Phase 1 Travoprost ophthalmic solution, 0.004% (new formulation)
8 The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma Unknown status NCT01020721
9 Endoscopic Goniotomy for Infantile Glaucoma Completed NCT00338533
10 Quality of Life in Children Glaucoma and Cataract Completed NCT02490267
11 The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops Completed NCT01925391 Early Phase 1 Tono-pen XL Applanation tonometer + Ocu-film +
12 Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation Completed NCT02945176
13 Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases Completed NCT00076271
14 mRNA Expression in Lymphocytes of Glaucoma Patients Completed NCT00327509
15 Genetic Testing in Primary Congenital Glaucoma Patients Recruiting NCT01136460
16 Prospective Study of the Diagnostic and Therapeutic Management of Congenital Glaucoma in France Recruiting NCT03077789
17 Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma Recruiting NCT03016156
18 Aqueous Humor Dynamics and Biometric Parameters in Eyes of Children Recruiting NCT01290588
19 Repository for Inherited Eye Diseases Suspended NCT00378742

Search NIH Clinical Center for Hydrophthalmos

Cochrane evidence based reviews: hydrophthalmos

Genetic Tests for Hydrophthalmos

Anatomical Context for Hydrophthalmos

MalaCards organs/tissues related to Hydrophthalmos:

38
Eye, Testes

Publications for Hydrophthalmos

Articles related to Hydrophthalmos:

# Title Authors Year
1
A contribution to the surgical treatment of hydrophthalmos. ( 5893381 )
1965
2
PERSISTENT PUPILLARY MEMBRANE; ASSOCIATED WITH HYDROPHTHALMOS, CORECTOPIA, CATARACT AND MYOPIA. ( 14070714 )
1963
3
Hydrophthalmos and neurofibromatosis (von Recklinghausen). ( 13652533 )
1959
4
Organic-aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation; a clinical entity. ( 14884753 )
1952
5
A Collective Study of the Treatment of Congenital Hydrophthalmos. ( 16692688 )
1924
6
Hydrophthalmos (Buphthalmos or Infantile Glaucoma)-Report of a Case with Microscopic Findings. ( 16692647 )
1923

Variations for Hydrophthalmos

Expression for Hydrophthalmos

Search GEO for disease gene expression data for Hydrophthalmos.

Pathways for Hydrophthalmos

Pathways related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.29 FOXC1 PITX2

GO Terms for Hydrophthalmos

Biological processes related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 camera-type eye development GO:0043010 9.26 FOXC1 PITX2
2 odontogenesis of dentin-containing tooth GO:0042475 9.16 FOXC1 PITX2
3 collagen fibril organization GO:0030199 8.96 CYP1B1 FOXC1
4 positive regulation of DNA binding GO:0043388 8.62 FOXC1 PITX2

Sources for Hydrophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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