MCID: HYD012
MIFTS: 44

Hydrops Fetalis malady

Categories: Genetic diseases, Rare diseases, Fetal diseases, Immune diseases

Aliases & Classifications for Hydrops Fetalis

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Aliases & Descriptions for Hydrops Fetalis:

Name: Hydrops Fetalis 47 26 49 67
Hydrops Fetalis Nonimmune 47 26
Familial Non-Immune Hydrops Fetalis 47
 
Hydrops Fetalis, Non-Immune 67
Idiopathic Hydrops Fetalis 47

Classifications:



External Ids:

ICD1029 P56, P56.0, P56.9

Summaries for Hydrops Fetalis

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Wikipedia:70 Hydrops fetalis is a condition in the fetus characterized by an accumulation of fluid, or edema, in at... more...

MalaCards based summary: Hydrops Fetalis, also known as hydrops fetalis nonimmune, is related to hepatitis and hydrops fetalis, nonimmune, and has symptoms including joint swelling, joint swelling and fetal tachycardia. An important gene associated with Hydrops Fetalis is NEU1 (Neuraminidase 1), and among its related pathways are Lysosome and Glycosaminoglycan metabolism. Affiliated tissues include heart, placenta and lung, and related mouse phenotype homeostasis/metabolism.

Related Diseases for Hydrops Fetalis

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Diseases related to Hydrops Fetalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.0GPI, HBA1
2hydrops fetalis, nonimmune12.7
3immune hydrops fetalis12.4
4hydrops fetalis anemia immune disorder absent thumb12.0
5mucopolysaccharidosis vii11.5
6fetal edema11.4
7pyruvate kinase deficiency11.3
8glucose phosphate isomerase deficiency11.3
9achondrogenesis, type ii or hypochondrogenesis11.1
10hemoglobin h disease, nondeletional11.1
11semmekrot haraldsson weemaes syndrome11.0
12gaucher disease, perinatal lethal11.0
13greenberg skeletal dysplasia11.0
14chondrodysplasia, blomstrand type11.0
15porphyria, congenital erythropoietic11.0
16thalassemias, alpha-11.0
17lymphangiectasia, pulmonary, congenital11.0
18short-rib thoracic dysplasia 1211.0
19hypochondrogenesis11.0
20fetal parvovirus syndrome11.0
21thalassemia10.4
22chorioangioma10.3
23teratoma10.2
24mucopolysaccharidosis10.2
25lysosomal storage disease10.2
26hemophagocytic lymphohistiocytosis10.1
27down syndrome10.1
28syphilis10.1
29pulmonary sequestration10.1
30diamond-blackfan anemia10.0
31lymphedema10.0
32cerebritis10.0
33mediastinitis10.0
34congenital syphilis10.0
35cardiomyopathy10.0
36endocardial fibroelastosis10.0
37sacrococcygeal teratoma10.0
38congenital dyserythropoietic anemia10.0
39hemoglobinopathy10.0
40polyhydramnios10.0
41herpes simplex10.0
42cytomegalovirus infection10.0
43tetralogy of fallot9.9
44galactosialidosis9.9
45hemochromatosis9.9
46ebstein anomaly9.9
47hemangioma9.9
48hydrocephalus9.9
49leukemia9.9
50congenital hypothyroidism9.9

Graphical network of the top 20 diseases related to Hydrops Fetalis:



Diseases related to hydrops fetalis

Symptoms for Hydrops Fetalis

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UMLS symptoms related to Hydrops Fetalis:


joint swelling, fetal tachycardia, fetal bradycardia

Drugs & Therapeutics for Hydrops Fetalis

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Drugs for Hydrops Fetalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Betamethasoneapproved, vet_approvedPhase 1, Phase 2183378-44-99782
Synonyms:
.beta.-Methasone
.beta.-Methasone alcohol
1,4-Pregnadiene-3,20-dione-9alpha-fluoro-16 beta-methyl-11 beta,17alpha,21-triol
16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione
16β-Methyl-1,4-pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione
24024-03-1
34166_FLUKA
34166_RIEDEL
378-44-9
4-08-00-03501 (Beilstein Handbook Reference)
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
9-Fluoro-16.beta.-methylprednisolone
9-Fluoro-16beta-methylprednisolone
9-Fluoro-16β-methylprednisolone
9-alpha-Fluoro-16-beta-methylprednisolone
9.alpha.-Fluoro-16.beta.-methylprednisolone
9alpha-Fluoro-16 beta-methyl-prednisolone
9alpha-Fluoro-16beta-methylprednisolone
9α-Fluoro-16β-methylprednisolone
AC1L1EYE
AC1L1TT4
AC1Q5HJZ
AKOS001582690
AR-1A7284
AR-1H5595
B1837
B7005_SIAL
B7005_SIGMA
B9675_SIAL
BIDD:PXR0047
BPBio1_000533
BRD-A35108200-001-04-7
BRD-K39188321-001-03-9
BRN 3176546
BSPBio_000483
Bebate
Becort
Bedifos
Betacorlan
Betacortril
Betadexamethasone
Betafluorene
Betamamallet
Betametasona
Betametasona [INN-Spanish]
Betametasone
Betametasone [DCIT]
Betamethasone
Betamethasone (JP15/USP/INN)
Betamethasone Base
Betamethasone Valearate
Betamethasone [USAN:BAN:INN:JAN]
Betamethasone [USAN:INN:BAN:JAN]
Betamethasone alcohol
Betamethasone cream
Betamethasonum
Betamethasonum [INN-Latin]
Betamethasonvalerat Mikron
Betamethazone
Betapredol
Betasolon
Betnelan
 
Betsolan
C22H29FO5
CHEBI:3077
CHEMBL632
CID3003
CID9782
CPD000339803
Celestene
Celeston
Celestona
Celestone
Celestone Syrup and Tablets
Celestone, Betadexamethasone, Flubenisolone, Sch-4831, NCS-39470, Betamethasone
Cellestoderm
Cidoten
D00244
D1961
DB00443
Desacort-Beta
EINECS 206-825-4
Flubenisolone
HMS1569I05
HSDB 3015
Hormezon
I06-0121
KST-1A3042
LS-118466
LT00441022
Luxiq
Luxiqo
MLS-0310139.0001
MLS000686794
MLS000859943
MLS001066413
MLS001332616
MLS002153244
Methazon
MolPort-003-845-025
MolPort-007-981-051
NCGC00164401-01
NCGC00164401-02
NSC 39470
NSC-39470
NSC39470
Prestwick0_000362
Prestwick1_000362
Prestwick2_000362
Prestwick3_000362
Prestwick_703
Rinderon
Rinderon (TN)
Rinderon A
S1500_Selleck
SAM002589959
SCH 4831
SCH-4831
SMP1_000043
SMR000058601
SMR000339803
SPBio_002404
UNII-9842X06Q6M
Valisone
Visubeta
ZINC03876136
beta-Methasone
beta-Methasone alcohol
betamethasone
2Hormone AntagonistsPhase 1, Phase 212778
3HormonesPhase 1, Phase 213979
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 1, Phase 212767
5glucocorticoidsPhase 1, Phase 24920
6Respiratory System AgentsPhase 1, Phase 24818
7Betamethasone-17,21-dipropionatePhase 1, Phase 2183
8Anti-Inflammatory AgentsPhase 1, Phase 210355
9Betamethasone benzoatePhase 1, Phase 2183
10Betamethasone sodium phosphatePhase 1, Phase 2183
11Anti-Asthmatic AgentsPhase 1, Phase 23369
12Betamethasone ValeratePhase 1, Phase 21832152-44-5
13
MentholapprovedPhase 123532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

idNameStatusNCT IDPhase
1Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)TerminatedNCT00670956Phase 1, Phase 2
2In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)Not yet recruitingNCT02986698Phase 1
3Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGRTerminatedNCT00143039Phase 1
4Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine TreatmentNot yet recruitingNCT02956564

Search NIH Clinical Center for Hydrops Fetalis

Genetic Tests for Hydrops Fetalis

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Genetic tests related to Hydrops Fetalis:

id Genetic test Affiliating Genes
1 Hydrops Fetalis26
2 Nonimmune Hydrops Fetalis26

Anatomical Context for Hydrops Fetalis

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MalaCards organs/tissues related to Hydrops Fetalis:

35
Heart, Placenta, Lung, Brain, Bone, Testes, Endothelial

Animal Models for Hydrops Fetalis or affiliated genes

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MGI Mouse Phenotypes related to Hydrops Fetalis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9GBE1, GPI, GUSB, NEU1, PIEZO1

Publications for Hydrops Fetalis

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Articles related to Hydrops Fetalis:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Chylous Ascites in a Neonate with Hydrops Fetalis. (27670562)
2016
2
Hydrops Fetalis Associated with Compound Heterozygosity for Hb Zurich-Albisrieden (HBA2: C.178Ga88>a88C) and the Southeast Asian (- -(SEA)/) Deletion. (27686733)
2016
3
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. (26914330)
2016
4
Society for maternal-fetal medicine (SMFM) clinical guideline #7: nonimmune hydrops fetalis. (25557883)
2015
5
Nonimmune hydrops fetalis with ebstein anomaly. (25148508)
2014
6
Staged pacemaker implantation in a preterm with hydrops fetalis due to complete heart block. (23626451)
2013
7
Reply-nonimmune hydrops fetalis and lysosomal storage diseases. (24120156)
2013
8
Adrenal cytomegaly is a frequent pathologic finding in hemoglobin bart hydrops fetalis. (22257311)
2012
9
Intrauterine blood transfusion in immune hydrops fetalis, corrects middle cerebral artery Doppler velocimetry very quickly. (22364302)
2012
10
CCBE1 mutations can cause a mild, atypical form of generalized lymphatic dysplasia but are not a common cause of non-immune hydrops fetalis. (22239599)
2012
11
Venous Doppler studies in low-output and high-output hydrops fetalis. (20684946)
2010
12
Homozygosity for the Mediterranean a-thalassemic deletion (hemoglobin Barts hydrops fetalis). (20220267)
2010
13
Transfusion medicine illustrated: Intrauterine transfusion for homozygous alpha(0) thalassemia reverses hydrops fetalis. (19638154)
2009
14
Prenatal diagnosis of hemoglobin Bart's hydrops fetalis with gap-PCR system. (19816007)
2009
15
Atrial hemangioma: a rare cause of hydrops fetalis and intrauterine fetal death. (16621228)
2007
16
Prenatal diagnosis of partial trisomy 1q and monosomy X in a fetus with a congenital lung lesion and hydrops fetalis. (17431907)
2007
17
Microsatellite markers within --SEA breakpoints for prenatal diagnosis of HbBarts hydrops fetalis. (17158194)
2007
18
Second-trimester diagnosis of mucopolysaccharidosis type IV a presenting as hydrops fetalis. (16865740)
2006
19
Hemoglobin H hydrops fetalis syndrome resulting from the association of the - -SEA deletion and the alphaQuong Szealpha mutation in a Chinese woman. (16104884)
2005
20
Sonographic features of Ebstein anomaly associated with hydrops fetalis: a report of two cases. (15756659)
2005
21
Alpha-thalassemia: Hb H disease and Hb Barts hydrops fetalis. (16339648)
2005
22
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia. (15211660)
2004
23
Pathologic quiz case: a 5-day-old boy with hydrops fetalis. Mucolipidoses I (Sialidosis III). (12873188)
2003
24
Value of autopsy in nonimmune hydrops fetalis: series of 51 stillborn fetuses. (12016530)
2002
25
Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection. (10770616)
2000
26
Identification of Gaucher cells in the chorionic villi associated with recurrent hydrops fetalis. (10833378)
2000
27
Investigation of nonimmune hydrops fetalis: multidisciplinary studies are necessary for diagnosis--review of 94 cases. (10441620)
1999
28
Nonimmune hydrops fetalis. (10818859)
1999
29
Three-dimensional sonographic features of Hydrops fetalis. (10545740)
1999
30
Hydrops fetalis caused by alpha-thalassemia: an emerging health care problem. (9516118)
1998
31
Familial non-immune hydrops fetalis and congenital pulmonary lymphangiectasia. (9667408)
1998
32
Mucopolysaccharidosis type VII associated with hydrops fetalis: histopathological and ultrastructural features with genetic implications. (9155679)
1997
33
Second-trimester hydrops fetalis in pregnancies affected by homozygous alpha-thalassaemia-1. (9110371)
1997
34
Human parvovirus B19 infection associated with hydrops fetalis. (9325515)
1997
35
Diagnosis and management of early non-immune hydrops fetalis. (9509544)
1997
36
A case of hydrops fetalis, probably due to antibodies directed against antigenic determinants of GP.Mur (Miltenberger class III) cells. (15387736)
1996
37
Antenatal human parvovirus B19 infection and nonimmune hydrops fetalis presenting as severe preeclampsia. (8883769)
1996
38
Prognostic factors and prenatal management in non immune hydrops fetalis are still a dilemma. (8950726)
1996
39
Hematologic disorders and nonimmune hydrops fetalis. (8822334)
1995
40
Agenesis of the ductus venosus and its correlation to hydrops fetalis and the fetal hepatic circulation: case reports and review of the literature. (8736596)
1995
41
Cardiac abnormalities associated with hydrops fetalis. (8822332)
1995
42
Immunohistochemical distribution of surfactant apoproteins in hypoplastic lungs of nonimmunologic hydrops fetalis. (7590701)
1995
43
Non-immunological hydrops fetalis and intrapericardial teratoma: case report and review. (8559758)
1995
44
Osteopenia, abnormal dentition, hydrops fetalis and communicating hydrocephalus. (8591675)
1995
45
Four cases of absent ductus venosus: three in combination with severe hydrops fetalis. (7880437)
1994
46
Nonimmune hydrops fetalis associated with maternal infection with syphilis. (1442955)
1992
47
Intrauterine transfusion treatment of nonimmune hydrops fetalis secondary to human parvovirus B19 infection. (1849704)
1991
48
Clinico-pathological findings in non-immune hydrops fetalis. (1817125)
1991
49
Nonimmune hydrops fetalis associated with genetic abnormalities. (2406672)
1990
50
Hydrops fetalis from B19 parvovirus infection. (2177495)
1990

Variations for Hydrops Fetalis

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Clinvar genetic disease variations for Hydrops Fetalis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NEU1NM_000434.3(NEU1): c.353-2A> GSNVPathogenicrs864309513GRCh37Chr 6, 31829229: 31829229
2NEU1NM_000434.3(NEU1): c.1170C> G (p.Tyr390Ter)SNVPathogenicrs746607723GRCh37Chr 6, 31827574: 31827574
3GUSBNM_000181.3(GUSB): c.1144C> T (p.Arg382Cys)SNVLikely pathogenic, Pathogenicrs121918173GRCh37Chr 7, 65439613: 65439613
4GUSBNM_000181.3(GUSB): c.1069C> T (p.Arg357Ter)SNVLikely pathogenic, Pathogenicrs121918185GRCh37Chr 7, 65439688: 65439688

Expression for genes affiliated with Hydrops Fetalis

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Search GEO for disease gene expression data for Hydrops Fetalis.

Pathways for genes affiliated with Hydrops Fetalis

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GO Terms for genes affiliated with Hydrops Fetalis

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Cellular components related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:004320210.1GUSB, NEU1
2extracellular exosomeGO:00700627.6GBE1, GPI, GUSB, HBA1, NEU1

Biological processes related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate metabolic processGO:00059759.5GPI, GUSB

Sources for Hydrops Fetalis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet