MCID: HYD012
MIFTS: 61

Hydrops Fetalis malady

Fetal, Cardiovascular, Skin, Immune, Genetic categories

Summaries for Hydrops Fetalis

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Hydrops fetalis is a serious condition in which abnormal amounts of fluid build up in two or more body areas of a fetus or newborn. there are two types of hydrops fetalis: immune and nonimmune. immune hydrops fetalis is a complication of a severe form of rh incompatibility. rh compatibility causes massive red blood cell destruction, which leads to several problems, including total body swelling. severe swelling can interfere with how the body organs work. nonimmune hydrops fetalis occurs when a disease or medical condition disrupts the body's ability to manage fluid. there are three main causes for this type: heart or lung problems, severe anemia (thalassemia), and genetic defects, including turner syndrome. the exact cause depends on which form a baby has. last updated: 1/25/2012

MalaCards: Hydrops Fetalis, also known as idiopathic hydrops fetalis, is related to alpha thalassemia and thalassemia, and has symptoms including hydrops fetalis An important gene associated with Hydrops Fetalis is GPI (glucose-6-phosphate isomerase), and among its related pathways are Other glycan degradation and Lysosome. The compounds 4-methylumbelliferone and cellulose acetate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are integument and liver/biliary system.

Wikipedia:64 Hydrops fetalis is a condition in the fetus characterized by an accumulation of fluid, or edema, in at... more...

Description from OMIM:47 236750

Aliases & Classifications for Hydrops Fetalis

Sources:
43NIH Rare Diseases, 22GTR, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal, Genetic
Anatomical: Cardiovascular, Skin, Immune


Characteristics (Orphanet epidemiological data):

49
hydrops fetalis:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

hydrops fetalis 43 22 45 49 47 61
idiopathic hydrops fetalis 43 49
familial non-immune hydrops fetalis 43
hydrops fetalis, non-immune 61
hydrops fetalis, nonimmune 45
hydrops fetalis nonimmune 43
fetal hydrops 49
fetal edema 49


External Ids:

OMIM47 236750
MESH via Orphanet36 D015160, C531708
ICD10 via Orphanet26 P56, P83.2
SNOMED-CT via Orphanet58 276508000, 206538000
UMLS via Orphanet62 C0020305
ICD1025 P56, P56.0, P56.9

Related Diseases for Hydrops Fetalis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hydrops Fetalis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1alpha thalassemia31.1HBB, HBA2, HBZ
2thalassemia31.1HBA2, HBB, HBE1
3hemophagocytic lymphohistiocytosis30.6UNC13D, PRF1
4beta thalassemia30.5HBA2, HBB
5lymphedema, congenital30.5FLT4, FOXC2
6klippel-trenaunay syndrome30.4FLT4, FOXC2
7hepatitis c30.1PTPN11, NEU1
8gaucher's disease30.1GBA
9thrombocytopenia30.1GBA, GUSB
10congenital disorder of glycosylation type 1a30.1PMM2, NEU1
11deficiency anemia30.1RHD, HBA2, HBB, HBE1, GBA, GPI
12immune hydrops fetalis11.0
13chorioangioma10.7
14hb bart's hydrops fetalis10.7
15n syndrome10.6
16teratoma10.6
17congenital pulmonary lymphangiectasia10.5
18congenital heart block10.5
19syphilis10.5
20twin twin transfusion syndrome10.5
21pulmonary sequestration10.5
22diamond-blackfan anemia10.4
23mucopolysaccharidosis i10.4
24fetal adenoma10.4
25adenoma10.4
26non-immune hydrops fetalis10.4
27ebstein anomaly10.4
28congenital dyserythropoietic anemia10.4
29polyhydramnios10.4
30fetal edema10.4
31hydrops fetalis anemia immune disorder absent thumb10.4
32sacrococcygeal teratoma10.4
33cytomegalovirus infection10.4
34mesoblastic nephroma10.4
35niemann-pick disease10.3
36sly syndrome10.3
37congenital hypothyroidism10.3
38hereditary lymphedema10.3
39hemochromatosis10.3
40endocardial fibroelastosis10.3
41achondrogenesis type ib10.3
42neonatal hemochromatosis10.3
43niemann–pick disease10.3
44hemophagocytic lymphohistiocytosis, familial10.3
45hydrops, ectopic calcification, moth-eaten skeletal dysplasia10.3
46chondrodysplasia blomstrand type10.3
47galactosialidosis10.3
48chylothorax, congenital10.3
49congenital myotonic dystrophy10.3
50fetal parvovirus syndrome10.3

Graphical network of the top 20 diseases related to Hydrops Fetalis:



Diseases related to hydrops fetalis

Clinical Features for Hydrops Fetalis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

236750

Symptoms:

49
  • hydrops fetalis

Drugs & Therapeutics for Hydrops Fetalis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hydrops Fetalis

Drug clinical trials:

Search ClinicalTrials for Hydrops Fetalis

Search NIH Clinical Center for Hydrops Fetalis

Search CenterWatch for Hydrops Fetalis

Genetic Tests for Hydrops Fetalis

Sources:
22GTR
See all sources

Genetic tests related to Hydrops Fetalis:

id Genetic test Affiliating Genes
1 Hydrops Fetalis22

Anatomical Context for Hydrops Fetalis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hydrops Fetalis:

33
Bone marrow, Brain, Heart, Colon, Kidney, Lung, Pancreas, Adrenal gland, Placenta, T cells, Endothelial, Fetal brain, Cardiac myocytes, Fetal lung, Pituitary

Animal Models for Hydrops Fetalis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hydrops Fetalis

Sources:
51PubMed
See all sources

Articles related to Hydrops Fetalis:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Neonatal Bartter syndrome and unilateral ectopic renal cyst as new renal causes of hydrops fetalis: two case reports and review of the literature. (23484775)
2013
2
Etiology and Outcome of Hydrops Fetalis. (24345792)
2013
3
CCBE1 mutations can cause a mild, atypical form of generalized lymphatic dysplasia but are not a common cause of non-immune hydrops fetalis. (22239599)
2012
4
Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. (21592689)
2011
5
Is Langerhan cell histiocytosis complicated with hydrops fetalis exclusively lethal in premature neonates? (21438915)
2011
6
Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents? (21268039)
2011
7
Type 1 Bland Sutton colonic atresia complicated by fetalis hydrops in a premature neonate. (21680307)
2011
8
Hydrops fetalis associated with homozygosity for Hb Adana [alpha59(E8)Gly-->Asp (alpha2)]. (20642338)
2010
9
Acute non-immune hydrops fetalis caused by intrauterine echovirus infection. (22791477)
2010
10
Hydrops fetalis associated with chorioangioma and thrombosis of umbilical vein. (20112613)
2009
11
Survival in primary congenital pulmonary lymphangiectasia with hydrops fetalis. (18753762)
2008
12
Congenital gastric outlet obstruction and nonimmune hydrops fetalis: a prenatal sonographic diagnosis of a case with hydrothorax and ascites. (18836660)
2008
13
Transplacental digitalization for nonimmune hydrops fetalis caused by isolated noncompaction of the ventricular myocardium. (17384050)
2007
14
Flecainide treatment of fetal tachycardia and hydrops fetalis in a twin pregnancy. (16736448)
2006
15
Lysosomal storage diseases in non-immune hydrops fetalis pregnancies. (16674934)
2006
16
Hydrops fetalis caused by a large intrapericardial teratoma. (17051615)
2006
17
Investigation of lysosomal storage diseases in nonimmune hydrops fetalis. (15305357)
2004
18
Fatal hydrops fetalis caused by anti-D in a mother with partial D. (15229025)
2004
19
Fatal hydrops fetalis caused by anti-D in a mother with partial D. (14607035)
2003
20
Recurrent hydrops fetalis due to Kell allo-immunization. (17264635)
2000
21
Good prognosis for psychomotor development in survivors with nonimmune hydrops fetalis. (10688515)
2000
22
Screening for (--SEA) alpha-globin gene deletion in beta-thalassemia carriers and prevention of hydrops fetalis. (10980643)
2000
23
Hydrops fetalis with complete heart block secondary to congenital lupus: report of one case. (10910626)
1999
24
Management of acute chylothorax with hydrops fetalis diagnosed in the third trimester of pregnancy. (10529566)
1999
25
Recurrent nonimmune hydrops fetalis associated with carbohydrate-deficient glycoprotein syndrome. (9762608)
1998
26
The incidence of, and factors leading to, parvovirus B19-related hydrops fetalis following maternal infection; report of 10 cases and meta-analysis. (9733374)
1998
27
Type 2 Gaucher disease with hydrops fetalis in an Ashkenazi Jewish family resulting from a novel recombinant allele and a rare splice junction mutation in the glucocerebrosidase locus. (9635296)
1998
28
Neutropenia complicating Rh-hydrops fetalis: the effect of treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF). (9592847)
1998
29
Survival of a preterm neonate with late onset hydrops fetalis due to parvovirus B19 infection. (9825979)
1998
30
Prenatal diagnosis of tetralogy of Fallot with absent pulmonary valve accompanied by hydrops fetalis. (9251957)
1997
31
Angiotensin mediated interaction of fetal kidney and placenta in the control of fetal arterial pressure and its role in hydrops fetalis. (9179925)
1997
32
A case of hydrops fetalis, probably due to antibodies directed against antigenic determinants of GP.Mur (Miltenberger class III) cells. (15387736)
1996
33
Successful outcome of idiopathic nonimmune hydrops fetalis treated by maternal digoxin. (8878721)
1996
34
Prognostic factors and prenatal management in non immune hydrops fetalis are still a dilemma. (8950726)
1996
35
Human parvovirus B19 associated non-immune hydrops fetalis. (8991362)
1996
36
Identification of human parvovirus B19 infection in idiopathic nonimmune hydrops fetalis. (8572031)
1996
37
Osteopenia, abnormal dentition, hydrops fetalis and communicating hydrocephalus: unusual early clinical signs in Coffin-Lowry syndrome. (8937775)
1996
38
Infectious causes of hydrops fetalis. (8822333)
1995
39
Prune-belly syndrome in a female, complicated by intestinal malrotation after successful antenatal treatment of hydrops fetalis. (8523251)
1995
40
Nonimmune hydrops fetalis, hydramnios, microcephaly, and intracranial meningeal hemangioendothelioma. (8474956)
1993
41
Aggressive direct treatment of a fetus with supraventricular tachycardia and hydrops fetalis. (12797277)
1993
42
A case of spontaneous resolution of nonimmune hydrops fetalis. (8498951)
1993
43
Idiopathic arterial calcification in a stillborn complicated by pleural hemorrhage and hydrops fetalis. (1536617)
1992
44
Intrauterine brain damage in nonimmune hydrops fetalis. (1391252)
1992
45
Investigations into a possible immunological origin of idiopathic non-immune hydrops fetalis and initial results of prophylactic immune treatment of subsequent pregnancies. (1858493)
1991
46
Differential diagnosis and causes of nonimmunological hydrops fetalis: a review. (1902927)
1991
47
Parvovirus B19, hydrops fetalis, and fetal wastage. An etiologic sequence. (1648877)
1991
48
Nonimmune hydrops fetalis caused by a massive fetomaternal hemorrhage associated with elevated maternal serum alpha-fetoprotein levels. A case report. (1693688)
1990
49
Immune hydrops fetalis attributable to anti-HJK. (2216274)
1990
50
Hydrops fetalis, hydramnios and hepatic vascular malformation associated with cutaneous hemangioma and chorioangioma. (343490)
1978

Genetic Variations for Hydrops Fetalis

Expression for genes affiliated with Hydrops Fetalis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hydrops Fetalis

Search GEO for disease gene expression data for Hydrops Fetalis.

Pathways for genes affiliated with Hydrops Fetalis

Sources:
30KEGG, 54Reactome
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Compounds for genes affiliated with Hydrops Fetalis

Sources:
45Novoseek, 24HMDB, 11DrugBank
See all sources

Compounds related to Hydrops Fetalis according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
14-methylumbelliferone4510.5GUSB, NEU1
2cellulose acetate4510.4NEU1, HBA2, GPI
323-diphosphoglycerate4510.4HBB, HBA2
4neomycin4510.3HBB, GUSB, GBA
5castanospermine4510.3GBA, NEU1
6glucose 6-phosphate45 2411.2TALDO1, HBB, GPI
7fructose-6-phosphate45 1111.2GPI, TALDO1
8fructose-1,6-bisphosphate4510.2TALDO1, GPI
9polyacrylamide4510.2NEU1, GPI, HBB, RHD
10mannose4510.1PMM2, NEU1, ALG1, GBA
11glyceraldehyde 3-phosphate4510.1TALDO1, GPI, HBB, RHD
12histidine4510.1GPI, TALDO1, PRF1, HBB
13mannose 6-phosphate45 2411.1GUSB, GPI, GBA, NEU1, PMM2
14galactose4510.1GBA, NEU1, RHD
15methionine4510.0RHD, HBA2, PTPN11, HBB
16adenylate4510.0HBB, HBA2, RHD, GPI, GBA
17h2o2459.8NEU1, PTPN11, TALDO1, RHD, HBB
18oxygen45 2410.7FLT4, RHD, HBA2, HBB, GBA, TALDO1
19glucose459.7FOXC2, PTPN11, GPI, RHD, TALDO1, GBA
20serine459.5NEU1, RHD, PTPN11, GPI, HBB, GBA
21oligonucleotide459.4PTPN11, HBB, GPC3, HBA2, HBZ

GO Terms for genes affiliated with Hydrops Fetalis

Sources:
16Gene Ontology
See all sources

Cellular components related to Hydrops Fetalis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.2HBB, HBA2
2haptoglobin-hemoglobin complexGO:0318389.9HBA2, HBB
3lysosomal lumenGO:0432029.8GUSB, NEU1, GBA, GPC3
4hemoglobin complexGO:0058339.7HBE1, HBB, HBA2, HBZ

Biological processes related to Hydrops Fetalis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:01567110.3HBA2, HBB
2positive regulation of cell deathGO:01094210.2HBA2, HBB
3lymphangiogenesisGO:00194610.2FOXC2, FLT4
4regulation of blood vessel sizeGO:05088010.1HBB, FOXC2
5hydrogen peroxide catabolic processGO:0427449.9HBA2, HBB
6carbohydrate metabolic processGO:0059759.9GBA, TALDO1, GPI, GPC3, GUSB
7small molecule metabolic processGO:0442819.5HBB, NEU1, GPC3, GPI, GUSB, TALDO1

Molecular functions related to Hydrops Fetalis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:03172010.2HBB, HBA2
2peroxidase activityGO:00460110.2HBA2, HBB
3oxygen transporter activityGO:0053449.9HBZ, HBE1, HBB, HBA2
4oxygen bindingGO:0198259.8HBB, HBA2, HBZ, HBE1
5heme bindingGO:0200379.6HBB, HBZ, HBA2, HBE1
6iron ion bindingGO:0055069.4HBZ, HBE1, HBB, HBA2

Products for genes affiliated with Hydrops Fetalis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hydrops Fetalis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet