MCID: HYD012
MIFTS: 53

Hydrops Fetalis malady

Genetic diseases, Rare diseases, Fetal diseases, Immune diseases categories

Aliases & Classifications for Hydrops Fetalis

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Sources:
41NIH Rare Diseases, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Hydrops Fetalis, Aliases & Descriptions:

Name: Hydrops Fetalis 41 43 47 22 60
Generalized Fetal Edema 41 47
Fetal Anasarca 41 47
Fetal Hydrops 41 47
Hf 41 47
 
Familial Non-Immune Hydrops Fetalis 41
Hydrops Fetalis, Non-Immune 60
Idiopathic Hydrops Fetalis 41
Hydrops Fetalis, Nonimmune 43
Hydrops Fetalis Nonimmune 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Immune diseases


Characteristics (Orphanet epidemiological data):

47
hydrops fetalis:
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth


External Ids:

Orphanet47 1041
ICD10 via Orphanet26 P56.0, P56.9, P83.2
UMLS via Orphanet61 C0020305
MESH via Orphanet34 D015160
ICD1025 P56, P56.0, P56.9

Summaries for Hydrops Fetalis

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NIH Rare Diseases:41 Hydrops fetalis is a serious condition in which abnormal amounts of fluid build up in two or more body areas of a fetus or newborn. there are two types of hydrops fetalis: immune and nonimmune. immune hydrops fetalis is a complication of a severe form of rh incompatibility. rh compatibility causes massive red blood cell destruction, which leads to several problems, including total body swelling. severe swelling can interfere with how the body organs work. nonimmune hydrops fetalis occurs when a disease or medical condition disrupts the body's ability to manage fluid. there are three main causes for this type: heart or lung problems, severe anemia (thalassemia), and genetic defects, including turner syndrome. the exact cause depends on which form a baby has. last updated: 1/25/2012

MalaCards based summary: Hydrops Fetalis, also known as generalized fetal edema, is related to lysosomal storage disease and hepatitis, and has symptoms including hydrops fetalis, congestive heart failure and hydrops fetalis. An important gene associated with Hydrops Fetalis is GPI (glucose-6-phosphate isomerase), and among its related pathways are Glucuronidation and Lysosome. The compounds starch and 4-methylumbelliferone have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and placenta, and related mouse phenotypes are liver/biliary system and integument.

Wikipedia:63 Hydrops fetalis is a condition in the fetus characterized by an accumulation of fluid, or edema, in at... more...

Related Diseases for Hydrops Fetalis

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Diseases related to Hydrops Fetalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1lysosomal storage disease31.1NEU1, GUSB
2hepatitis31.1ALB, GUSB
3meningitis30.8ALB
4thrombocytopenia30.3GUSB, ALB
5hemolytic anemia30.1NEU1, HBA2, GPI
6immune hydrops fetalis11.1
7non-immune hydrops fetalis11.1
8hb bart's hydrops fetalis10.8
9thalassemia10.8
10chorioangioma10.7
11teratoma10.7
12mucopolysaccharidosis vii10.6
13mucopolysaccharidosis10.6
14systolic heart failure10.6
15congenital pulmonary lymphangiectasia10.6
16down syndrome10.5
17syphilis10.5
18pulmonary sequestration10.5
19chondrodysplasia, blomstrand type10.4
20greenberg skeletal dysplasia10.4
21achondrogenesis, type ii or hypochondrogenesis10.4
22diamond-blackfan anemia10.4
23hemophagocytic lymphohistiocytosis10.4
24lymphedema10.4
25congenital syphilis10.4
26mediastinitis10.4
27choledocholithiasis10.4GUSB
28gaucher disease, perinatal lethal10.4
29achondrogenesis, type ia10.4
30hypotrichosis-lymphedema-telangiectasia syndrome10.4
31pyruvate kinase deficiency10.4
32achondrogenesis ib10.4
33sialidosis, type i10.4
34thalassemias, alpha-10.4
35congenital heart block10.4
36sacrococcygeal teratoma10.4
37congenital dyserythropoietic anemia10.4
38endocardial fibroelastosis10.4
39polyhydramnios10.4
40cerebritis10.4
41hemoglobinopathy10.4
42herpes simplex10.4
43neonatal hemochromatosis10.4
44fetal parvovirus syndrome10.4
45hennekam syndrome10.4
46hydrops fetalis anemia immune disorder absent thumb10.4
47cytomegalovirus infection10.4
48mesoblastic nephroma10.4
49gaucher disease, type iii10.3
50multiple pterygium syndrome, lethal type10.3

Graphical network of the top 20 diseases related to Hydrops Fetalis:



Diseases related to hydrops fetalis

Symptoms for Hydrops Fetalis

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Symptoms:

 47
  • hydrops fetalis

HPO human phenotypes related to Hydrops Fetalis:

id Description Frequency HPO Source Accession
1 hydrops fetalis hallmark (90%) HP:0001789
2 congestive heart failure HP:0001635
3 hydrops fetalis HP:0001789
4 anemia HP:0001903

Drugs & Therapeutics for Hydrops Fetalis

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Drug clinical trials:

Search ClinicalTrials for Hydrops Fetalis

Search NIH Clinical Center for Hydrops Fetalis

Genetic Tests for Hydrops Fetalis

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Genetic tests related to Hydrops Fetalis:

id Genetic test Affiliating Genes
1 Hydrops Fetalis22

Anatomical Context for Hydrops Fetalis

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MalaCards organs/tissues related to Hydrops Fetalis:

31
Heart, Lung, Placenta, Brain, Testes, Bone marrow, Bone, Kidney, Pancreas, Adrenal gland, Cardiac myocytes, Pituitary

Animal Models for Hydrops Fetalis or affiliated genes

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MGI Mouse Phenotypes related to Hydrops Fetalis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.1ALB, CCBE1, NEU1, GPI
2MP:00107718.1CCBE1, NEU1, HBA2, GUSB
3MP:00053977.6GPI, GUSB, HBA2, NEU1, CCBE1
4MP:00053767.2ALB, CCBE1, NEU1, HBA2, GUSB, GPI
5MP:00053847.2GUSB, HBA2, NEU1, CCBE1, ALB
6MP:00107687.2GPI, GUSB, HBA2, NEU1, CCBE1, ALB

Publications for Hydrops Fetalis

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Articles related to Hydrops Fetalis:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
Staged pacemaker implantation in a preterm with hydrops fetalis due to complete heart block. (23626451)
2013
2
Reply-nonimmune hydrops fetalis and lysosomal storage diseases. (24120156)
2013
3
Prenatal-onset Niemann-Pick type C disease with nonimmune hydrops fetalis. (23597521)
2013
4
Non-immune hydrops fetalis: A prospective study of 53 cases. (24039125)
2013
5
Noncompaction of the ventricular myocardium and hydrops fetalis in cobalamin C disease. (23430797)
2013
6
Noncompaction of the ventricular myocardium and hydrops fetalis in cobalamin C disease: Response to letter "Disappearance of congenital noncompaction in hereditary cobalamin-C-deficiency 2.5 years after birth" by J. Finsterer and Claudia StAPllberger, DOI 10.1007/s10545-013-9612-4. (23974651)
2013
7
Lysosomal storage disorder in non-immunological hydrops fetalis (NIHF): more common than assumed? Report of four cases with transient NIHF and a review of the literature. (23137060)
2012
8
Adrenal cytomegaly is a frequent pathologic finding in hemoglobin bart hydrops fetalis. (22257311)
2012
9
Antenatal closure of the ductus arteriosus and hydrops fetalis. (21985268)
2011
10
Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. (21592689)
2011
11
Hydrops fetalis associated with homozygosity for Hb Adana [alpha59(E8)Gly-->Asp (alpha2)]. (20642338)
2010
12
Acute non-immune hydrops fetalis caused by intrauterine echovirus infection. (22791477)
2010
13
Venous Doppler studies in low-output and high-output hydrops fetalis. (20684946)
2010
14
Was alpha-thalassemia searched as a cause of non-immune "hydrops fetalis?". (21428207)
2010
15
Transient abnormal myelopoiesis associated with Down syndrome presenting as severe hydrops fetalis: a case report. (20160425)
2010
16
Hydrops fetalis associated with chorioangioma and thrombosis of umbilical vein. (20112613)
2009
17
Atrial hemangioma: a rare cause of hydrops fetalis and intrauterine fetal death. (16621228)
2007
18
Prenatal diagnosis of partial trisomy 1q and monosomy X in a fetus with a congenital lung lesion and hydrops fetalis. (17431907)
2007
19
Nonimmune hydrops fetalis diagnosed during the second half of pregnancy in Southern China. (17361085)
2007
20
Microsatellite markers within --SEA breakpoints for prenatal diagnosis of HbBarts hydrops fetalis. (17158194)
2007
21
Second-trimester diagnosis of mucopolysaccharidosis type IV a presenting as hydrops fetalis. (16865740)
2006
22
Severity of non-immune hydrops fetalis at birth continues to predict survival despite advances in perinatal care. (16757915)
2006
23
Hemoglobin H hydrops fetalis syndrome resulting from the association of the - -SEA deletion and the alphaQuong Szealpha mutation in a Chinese woman. (16104884)
2005
24
Sonographic features of Ebstein anomaly associated with hydrops fetalis: a report of two cases. (15756659)
2005
25
Alpha-thalassemia: Hb H disease and Hb Barts hydrops fetalis. (16339648)
2005
26
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia. (15211660)
2004
27
Hydrops fetalis and extralobar lung sequestration. (11976473)
2002
28
Value of autopsy in nonimmune hydrops fetalis: series of 51 stillborn fetuses. (12016530)
2002
29
Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection. (10770616)
2000
30
Investigation of nonimmune hydrops fetalis: multidisciplinary studies are necessary for diagnosis--review of 94 cases. (10441620)
1999
31
Nonimmune hydrops fetalis. (10818859)
1999
32
Familial non-immune hydrops fetalis and congenital pulmonary lymphangiectasia. (9667408)
1998
33
Recurrent nonimmune hydrops fetalis associated with carbohydrate-deficient glycoprotein syndrome. (9762608)
1998
34
Mucopolysaccharidosis type VII associated with hydrops fetalis: histopathological and ultrastructural features with genetic implications. (9155679)
1997
35
Second-trimester hydrops fetalis in pregnancies affected by homozygous alpha-thalassaemia-1. (9110371)
1997
36
Hydrops fetalis and neonatal leukemia in Down syndrome. (8718505)
1996
37
A case of hydrops fetalis, probably due to antibodies directed against antigenic determinants of GP.Mur (Miltenberger class III) cells. (15387736)
1996
38
Hematologic disorders and nonimmune hydrops fetalis. (8822334)
1995
39
Agenesis of the ductus venosus and its correlation to hydrops fetalis and the fetal hepatic circulation: case reports and review of the literature. (8736596)
1995
40
Cardiac abnormalities associated with hydrops fetalis. (8822332)
1995
41
Four cases of absent ductus venosus: three in combination with severe hydrops fetalis. (7880437)
1994
42
Antenatal diagnosis and outcome in hydrops fetalis. (8487153)
1993
43
DNA confirmation of congenital myotonic dystrophy in non-immune hydrops fetalis. (8140064)
1993
44
Genetic causes of hydrops fetalis. (1728027)
1992
45
Hydrops fetalis associated with congenital myotonic dystrophy. (1550167)
1992
46
Nonimmune hydrops fetalis associated with maternal infection with syphilis. (1442955)
1992
47
Absent thumb, immune disorder, and congenital anemia presenting with hydrops fetalis. (1632450)
1992
48
Antenatal classification of hydrops fetalis. (1731295)
1992
49
Intrauterine transfusion treatment of nonimmune hydrops fetalis secondary to human parvovirus B19 infection. (1849704)
1991
50
Nonimmune hydrops fetalis associated with genetic abnormalities. (2406672)
1990

Variations for Hydrops Fetalis

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Expression for genes affiliated with Hydrops Fetalis

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Search GEO for disease gene expression data for Hydrops Fetalis.

Pathways for genes affiliated with Hydrops Fetalis

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Pathways related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GUSB, GPI
29.5NEU1, GUSB
3
Show member pathways
thioredoxin pathway36
9.3ALB, HBA2
4
Show member pathways
9.3HBA2, ALB
5
Show member pathways
7.9ALB, NEU1, HBA2, GUSB, GPI

Compounds for genes affiliated with Hydrops Fetalis

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Compounds related to Hydrops Fetalis according to GeneCards Suite gene sharing:

(show all 27)
idCompoundScoreTop Affiliating Genes
1starch439.9GUSB, GPI
24-methylumbelliferone439.9NEU1, GUSB
3ketoprofen28 43 1211.9ALB, GUSB
4antipyrine43 1210.8GUSB, ALB
5amitriptyline43 28 49 1212.8GUSB, ALB
6furosemide43 59 28 49 24 1214.8ALB, GUSB
7glutaraldehyde439.8ALB, NEU1
8chlorpromazine28 43 49 1212.7NEU1, ALB
9vitamin b12439.7ALB, GUSB
10daunorubicin43 49 1211.7NEU1, GUSB
11dextran sulfate439.7ALB, NEU1
12irinotecan43 49 1211.7GUSB, ALB
13tetracycline43 1210.6GUSB, ALB
14sulfate43 2410.6GPI, GUSB
15mannitol43 1210.6ALB, GUSB
16polyethylene glycol439.5ALB, NEU1
17mannose 6-phosphate43 2410.5GPI, GUSB, NEU1
18hyaluronic acid43 2410.4ALB, NEU1
19citrate439.4ALB, GUSB
20lactate439.4ALB, GUSB, GPI
21creatinine439.4ALB, GUSB, GPI
22aspartate439.4GPI, GUSB, ALB
23zidovudine43 49 1211.3ALB, NEU1, GUSB
24histamine43 28 2411.3ALB, NEU1, GUSB
25agarose439.2NEU1, GPI
26heparin43 28 24 1212.2GUSB, NEU1, ALB
27cellulose acetate438.8ALB, NEU1, HBA2, GPI

GO Terms for genes affiliated with Hydrops Fetalis

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Cellular components related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.3ALB, HBA2
2lysosomal lumenGO:00432029.2NEU1, GUSB
3extracellular vesicular exosomeGO:00700627.8ALB, NEU1, HBA2, GUSB, GPI

Biological processes related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:00442817.9ALB, NEU1, HBA2, GUSB, GPI

Molecular functions related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oxygen bindingGO:00198259.3ALB, HBA2

Products for genes affiliated with Hydrops Fetalis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hydrops Fetalis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet