MCID: HYD012
MIFTS: 43

Hydrops Fetalis malady

Categories: Genetic diseases, Rare diseases, Fetal diseases, Immune diseases

Aliases & Classifications for Hydrops Fetalis

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Sources:
45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 37MESH via Orphanet, 66UMLS via Orphanet, 28ICD10 via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Hydrops Fetalis:

Name: Hydrops Fetalis 45 47 51 65
Familial Non-Immune Hydrops Fetalis 45
Hydrops Fetalis, Non-Immune 65
Idiopathic Hydrops Fetalis 45
Hydrops Fetalis, Nonimmune 47
 
Hydrops Fetalis Nonimmune 45
Generalized Fetal Edema 51
Fetal Anasarca 51
Fetal Hydrops 51
Hf 51

Characteristics:

Orphanet epidemiological data:

51
hydrops fetalis:
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth

Classifications:



External Ids:

Orphanet51 1041
MESH via Orphanet37 D015160
UMLS via Orphanet66 C0020305
ICD10 via Orphanet28 P56.0, P56.9, P83.2
ICD1027 P56, P56.0, P56.9
UMLS65 C0020305, C0455988

Summaries for Hydrops Fetalis

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NIH Rare Diseases:45 Hydrops fetalis is a serious condition in which abnormal amounts of fluid build up in two or more body areas of a fetus or newborn. there are two types of hydrops fetalis: immune and nonimmune. immune hydrops fetalis is a complication of a severe form of rh incompatibility. rh compatibility causes massive red blood cell destruction, which leads to several problems, including total body swelling. severe swelling can interfere with how the body organs work. nonimmune hydrops fetalis occurs when a disease or medical condition disrupts the body's ability to manage fluid. there are three main causes for this type: heart or lung problems, severe anemia (thalassemia), and genetic defects, including turner syndrome. the exact cause depends on which form a baby has. last updated: 1/25/2012

MalaCards based summary: Hydrops Fetalis, also known as familial non-immune hydrops fetalis, is related to immune hydrops fetalis and hydrops fetalis anemia immune disorder absent thumb, and has symptoms including abnormality of the heme biosynthetic pathway, anemia and hydrops fetalis. An important gene associated with Hydrops Fetalis is NEU1 (Neuraminidase 1 (Lysosomal Sialidase)), and among its related pathways are Lysosome and Binding and Uptake of Ligands by Scavenger Receptors. Affiliated tissues include heart, lung and breast.

Wikipedia:68 Hydrops fetalis is a condition in the fetus characterized by an accumulation of fluid, or edema, in at... more...

Related Diseases for Hydrops Fetalis

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Graphical network of the top 20 diseases related to Hydrops Fetalis:



Diseases related to hydrops fetalis

Symptoms for Hydrops Fetalis

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Symptoms:

 51
  • hydrops fetalis

HPO human phenotypes related to Hydrops Fetalis:

(show all 15)
id Description Frequency HPO Source Accession
1 abnormality of the heme biosynthetic pathway hallmark (90%) HP:0010472
2 anemia hallmark (90%) HP:0001903
3 hydrops fetalis hallmark (90%) HP:0001789
4 congestive heart failure hallmark (90%) HP:0001635
5 pallor hallmark (90%) HP:0000980
6 toxemia of pregnancy typical (50%) HP:0100603
7 hepatomegaly typical (50%) HP:0002240
8 splenomegaly typical (50%) HP:0001744
9 oligohydramnios typical (50%) HP:0001562
10 polyhydramnios typical (50%) HP:0001561
11 hydrocephalus typical (50%) HP:0000238
12 abnormality of the pericardium occasional (7.5%) HP:0001697
13 anemia HP:0001903
14 hydrops fetalis HP:0001789
15 congestive heart failure HP:0001635

Drugs & Therapeutics for Hydrops Fetalis

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Drugs for Hydrops Fetalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BetamethasoneapprovedPhase 1, Phase 2153378-44-99782
Synonyms:
.beta.-Methasone
.beta.-Methasone alcohol
1,4-Pregnadiene-3,20-dione-9alpha-fluoro-16 beta-methyl-11 beta,17alpha,21-triol
16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione
16β-Methyl-1,4-pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione
24024-03-1
34166_FLUKA
34166_RIEDEL
378-44-9
4-08-00-03501 (Beilstein Handbook Reference)
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
9-Fluoro-16.beta.-methylprednisolone
9-Fluoro-16beta-methylprednisolone
9-Fluoro-16β-methylprednisolone
9-alpha-Fluoro-16-beta-methylprednisolone
9.alpha.-Fluoro-16.beta.-methylprednisolone
9alpha-Fluoro-16 beta-methyl-prednisolone
9alpha-Fluoro-16beta-methylprednisolone
9α-Fluoro-16β-methylprednisolone
AC1L1EYE
AC1L1TT4
AC1Q5HJZ
AKOS001582690
AR-1A7284
AR-1H5595
B1837
B7005_SIAL
B7005_SIGMA
B9675_SIAL
BIDD:PXR0047
BPBio1_000533
BRD-A35108200-001-04-7
BRD-K39188321-001-03-9
BRN 3176546
BSPBio_000483
Bebate
Becort
Bedifos
Betacorlan
Betacortril
Betadexamethasone
Betafluorene
Betamamallet
Betametasona
Betametasona [INN-Spanish]
Betametasone
Betametasone [DCIT]
Betamethasone
Betamethasone (JP15/USP/INN)
Betamethasone Base
Betamethasone Dipropionate
Betamethasone Valearate
Betamethasone Valerate
Betamethasone [USAN:BAN:INN:JAN]
Betamethasone [USAN:INN:BAN:JAN]
Betamethasone alcohol
Betamethasone cream
Betamethasone dipropionate
Betamethasone sodium phosphate
Betamethasone valerate
Betamethasonum
Betamethasonum [INN-Latin]
Betamethasonvalerat Mikron
Betamethazone
Betapredol
 
Betasolon
Betnelan
Betsolan
C22H29FO5
CHEBI:3077
CHEMBL632
CID3003
CID9782
CPD000339803
Celestene
Celeston
Celestona
Celestone
Celestone Syrup and Tablets
Celestone, Betadexamethasone, Flubenisolone, Sch-4831, NCS-39470, Betamethasone
Cellestoderm
Cidoten
D00244
D1961
DB00443
Desacort-Beta
Diprolene
EINECS 206-825-4
Flubenisolone
HMS1569I05
HSDB 3015
Hormezon
I06-0121
KST-1A3042
LS-118466
LT00441022
Luxiq
Luxiqo
MLS-0310139.0001
MLS000686794
MLS000859943
MLS001066413
MLS001332616
MLS002153244
Methazon
MolPort-003-845-025
MolPort-007-981-051
NCGC00164401-01
NCGC00164401-02
NSC 39470
NSC-39470
NSC39470
Prestwick0_000362
Prestwick1_000362
Prestwick2_000362
Prestwick3_000362
Prestwick_703
Rinderon
Rinderon (TN)
Rinderon A
S1500_Selleck
SAM002589959
SCH 4831
SCH-4831
SMP1_000043
SMR000058601
SMR000339803
SPBio_002404
UNII-9842X06Q6M
Valisone
Visubeta
ZINC03876136
beta-Methasone
beta-Methasone alcohol
betamethasone
2Hormone AntagonistsPhase 1, Phase 210002
3HormonesPhase 1, Phase 211748
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 1, Phase 29988
5glucocorticoidsPhase 1, Phase 23896
6Respiratory System AgentsPhase 1, Phase 23931
7Betamethasone ValeratePhase 1, Phase 21532152-44-5
8Anti-Inflammatory AgentsPhase 1, Phase 28478
9Betamethasone benzoatePhase 1, Phase 2153
10Betamethasone sodium phosphatePhase 1, Phase 2153
11Anti-Asthmatic AgentsPhase 1, Phase 22796
12Betamethasone-17,21-dipropionatePhase 1, Phase 2153

Interventional clinical trials:

idNameStatusNCT IDPhase
1Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)TerminatedNCT00670956Phase 1, Phase 2
2Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGRTerminatedNCT00143039Phase 1

Search NIH Clinical Center for Hydrops Fetalis

Genetic Tests for Hydrops Fetalis

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Anatomical Context for Hydrops Fetalis

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MalaCards organs/tissues related to Hydrops Fetalis:

33
Heart, Lung, Breast, Endothelial, Bone, Brain, Prostate

Animal Models for Hydrops Fetalis or affiliated genes

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MGI Mouse Phenotypes related to Hydrops Fetalis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Hydrops Fetalis

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Articles related to Hydrops Fetalis:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
A Functional Polymorphism in the Promoter of MiR-143/145 Is Associated With the Risk of Cervical Squamous Cell Carcinoma in Chinese Women: A Case-Control Study. (26252302)
2015
2
Reply to H.J Adams et al: "Is FDG-PET/CT a sensitive and specific method for the detection of extranodal involvement in diffuse large B-cell lymphoma?" (26572073)
2015
3
USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma. (25519684)
2015
4
Serial position effects are sensitive predictors of conversion from MCI to Alzheimer's disease dementia. (24418056)
2014
5
Epididymal-testicular fusion anomalies in cryptorchidism are associated with proximal location of the undescended testis and with a widely patent processus vaginalis. (25048056)
2014
6
Death domain-associated protein DAXX promotes ovarian cancer development and chemoresistance. (23539629)
2013
7
Disseminated cysticercosis. (24197175)
2013
8
Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. (23863409)
2013
9
Effects of induced astigmatism on foot placement strategies when stepping onto a raised surface. (23717414)
2013
10
A novel mutation in CDKN1C in sibs with Beckwith-Wiedemann syndrome and cleft palate, sensorineural hearing loss, and supernumerary flexion creases. (23197429)
2013
11
Assessment of serum S100B and neuron specific enolase levels to evaluate the neurotoxA+c effects of organA+c solvent exposure. (23889347)
2013
12
Muscle microvascular recruitment predicts insulin sensitivity in middle-aged patients with type 1 diabetes mellitus. (22167126)
2012
13
Chorioangioma of placenta: a rare placental cause for adverse fetal outcome. (22754703)
2012
14
Neurohormonal activity and vascular properties late after aortic coarctation repair. (21429604)
2012
15
Reportable neurologic diseases in refugee camps in 19 countries. (22927678)
2012
16
Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor. (23092913)
2012
17
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. (20050669)
2010
18
Cell cycle kinases as therapeutic targets for cancer. (19568282)
2009
19
A case of spontaneous pneumothorax presenting with high-degree atrioventricular block. (19729170)
2009
20
Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms. (19715559)
2009
21
Correction of metabolic acidosis on serum albumin and protein catabolism in hemodialysis patients. (19218045)
2009
22
Substance-induced psychosis: a diagnostic conundrum. (18278990)
2008
23
Nigrostriatal involvement in ataxia with oculomotor apraxia type 1. (18004640)
2008
24
Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. (18566013)
2008
25
Interaction of papillomavirus E2 protein with the Brm chromatin remodeling complex leads to enhanced transcriptional activation. (17151122)
2007
26
RANKL upregulation associated with periodontitis and Porphyromonas gingivalis. (17539720)
2007
27
Sagittal synostosis in X-linked hypophosphatemic rickets and related diseases. (17551721)
2007
28
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. (17339891)
2007
29
Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. (17671209)
2007
30
Use of tumor necrosis factor inhibitors in uveitis. (17762615)
2007
31
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. (17652390)
2007
32
Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts. (17005594)
2006
33
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. (16051337)
2005
34
Chromogranin A: a surprising link between granule biogenesis and hypertension. (16007250)
2005
35
Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease. (11836800)
2002
36
Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells. (12114452)
2002
37
E-cadherin and beta-catenin are down-regulated in prostatic bone metastases. (11872032)
2002
38
A study of the correlation between p16 protein expression and DNA quantitative analysis in human gastric carcinoma cells]. (11866976)
2001
39
Genetic testing in acute and chronic pancreatitis. (11276378)
2001
40
Expression of peripheral myelin protein zero in sural nerve of patients with Charcot-Marie-Tooth disease 1B. (11182278)
2001
41
Loss of growth inhibitory effects of retinoic acid in human breast cancer cells following long-term exposure to retinoic acid. (11027432)
2000
42
Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (10080545)
1999
43
Not the right middle lobe syndrome? (9254755)
1997
44
11q23 rearrangements in acute leukemia. (8558942)
1996
45
Insulin-like growth factor-binding protein-3 (IGFBP-3) concentration in rat Sertoli cell-conditioned medium is regulated by a pathway involving association of IGFBP-3 with cell surface proteoglycans. (7516869)
1994
46
Insulin receptor tyrosine kinase domain auto-dephosphorylation. (1336369)
1992
47
Nevoid basal cell carcinoma syndrome: bilateral ovarian fibromas in a 3 1/2-year-old girl. (3950141)
1986
48
Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys. (98439)
1978
49
Bubonic plague misdiagnosed as tularemia. Retrospective serologic diagnosis. (4678367)
1972
50
Report of two cases of trichotillomania of long standing duration and their response to chlorpromazine. (13539186)
1958

Variations for Hydrops Fetalis

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Clinvar genetic disease variations for Hydrops Fetalis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NEU1NM_000434.3(NEU1): c.353-2A> Gsingle nucleotide variantPathogenicrs864309513GRCh37Chr 6, 31829229: 31829229
2NEU1NM_000434.3(NEU1): c.1170C> G (p.Tyr390Ter)single nucleotide variantPathogenicrs746607723GRCh38Chr 6, 31859797: 31859797
3GUSBNM_000181.3(GUSB): c.1144C> T (p.Arg382Cys)single nucleotide variantLikely pathogenic, Pathogenicrs121918173GRCh37Chr 7, 65439613: 65439613
4GUSBNM_000181.3(GUSB): c.1069C> T (p.Arg357Ter)single nucleotide variantLikely pathogenic, Pathogenicrs121918185GRCh37Chr 7, 65439688: 65439688

Expression for genes affiliated with Hydrops Fetalis

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Search GEO for disease gene expression data for Hydrops Fetalis.

Pathways for genes affiliated with Hydrops Fetalis

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Pathways related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6GUSB, NEU1
2
Show member pathways
9.3HBA1, HBA2
39.3HBA1, HBA2
4
Show member pathways
9.3HBA1, HBA2
59.3HBA1, HBA2
6
Show member pathways
9.3HBA1, HBA2
7
Show member pathways
8.7GBE1, GPI, GUSB
8
Show member pathways
8.7GBE1, GPI, GUSB
9
Show member pathways
7.1GBE1, GPI, GUSB, HBA1, HBA2, NEU1

GO Terms for genes affiliated with Hydrops Fetalis

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Cellular components related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:00318389.4HBA1, HBA2
2cytosolic small ribosomal subunitGO:00226279.3HBA1, HBA2

Biological processes related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor-mediated endocytosisGO:00068989.3HBA1, HBA2
2protein heterooligomerizationGO:00512919.2HBA1, HBA2

Molecular functions related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:00317209.5HBA1, HBA2
2peroxidase activityGO:00046019.3HBA1, HBA2
3oxygen transporter activityGO:00053449.0HBA1, HBA2

Sources for Hydrops Fetalis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet