HF
MCID: HYD012
MIFTS: 53

Hydrops Fetalis (HF) malady

Fetal diseases, Immune diseases, Genetic diseases categories

Summaries for Hydrops Fetalis

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Hydrops fetalis is a serious condition in which abnormal amounts of fluid build up in two or more body areas of a fetus or newborn. there are two types of hydrops fetalis: immune and nonimmune. immune hydrops fetalis is a complication of a severe form of rh incompatibility. rh compatibility causes massive red blood cell destruction, which leads to several problems, including total body swelling. severe swelling can interfere with how the body organs work. nonimmune hydrops fetalis occurs when a disease or medical condition disrupts the body's ability to manage fluid. there are three main causes for this type: heart or lung problems, severe anemia (thalassemia), and genetic defects, including turner syndrome. the exact cause depends on which form a baby has. last updated: 1/25/2012

MalaCards: Hydrops Fetalis, also known as familial non-immune hydrops fetalis, is related to alpha thalassemia and lysosomal storage disease, and has symptoms including hydrops fetalis An important gene associated with Hydrops Fetalis is GPI (glucose-6-phosphate isomerase), and among its related pathways are Other glycan degradation and Lysosome. The compounds 4-methylumbelliferone and cellulose acetate have been mentioned in the context of this disorder. Affiliated tissues include lung and heart, and related mouse phenotypes are integument and liver/biliary system.

Wikipedia:63 Hydrops fetalis is a condition in the fetus characterized by an accumulation of fluid, or edema, in at... more...

Description from OMIM:46 236750

Aliases & Classifications for Hydrops Fetalis

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Sources:
42NIH Rare Diseases, 22GTR, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Genetic diseases
Anatomical: Immune diseases


Characteristics (Orphanet epidemiological data):

48
hydrops fetalis:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

hydrops fetalis 42 22 44 48 46 60
familial non-immune hydrops fetalis 42
hydrops fetalis, non-immune 60
idiopathic hydrops fetalis 42
hydrops fetalis, nonimmune 44
hydrops fetalis nonimmune 42
generalized fetal edema 48
fetal anasarca 48
fetal hydrops 48
hf 48


External Ids:

OMIM46 236750
MESH via Orphanet35 D015160
ICD10 via Orphanet26 P56.0, P83.2, P56.9
SNOMED-CT via Orphanet57 276508000
UMLS via Orphanet61 C0020305
ICD1025 P56, P56.0, P56.9

Related Diseases for Hydrops Fetalis

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17GeneCards, 18GeneDecks
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Diseases related to Hydrops Fetalis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1alpha thalassemia31.0HBB, HBA2, HBZ
2lysosomal storage disease30.7GUSB, NEU1, GBA
3hepatitis30.7GPC3, HBE1, GUSB
4lymphedema30.6FOXC2, FLT4
5hemophagocytic lymphohistiocytosis30.6UNC13D, PRF1
6beta thalassemia30.5HBA2, HBB
7hemoglobinopathy30.5HBB, HBA2
8herpes simplex30.5NEU1, HBA2, HBB, GBA
9congenital disorder of glycosylation30.3PMM2, ALG1
10hemolytic anemia30.3NEU1, RHD, HBA2, HBB, GPI
11klippel-trenaunay syndrome30.3FLT4, FOXC2
12leukemia30.3GUSB, FLT4, RHD, HBA2, HBB, GBA
13mucopolysaccharidosis iv30.1GUSB, NEU1
14thrombocytopenia30.1GBA, GUSB
15congenital disorder of glycosylation type 1a30.1PMM2, NEU1
16deficiency anemia30.1RHD, HBA2, HBB, HBE1, GBA, GPI
17rhabdomyosarcoma29.9RHD, HBB, PTPN11
18thalassemia10.7
19chorioangioma10.7
20hb bart's hydrops fetalis10.7
21mucopolysaccharidosis10.5
22systolic heart failure10.5
23non-immune hydrops fetalis10.5
24congenital heart block10.4
25down syndrome10.4
26syphilis10.4
27immune hydrops fetalis10.4
28diamond-blackfan anemia10.4
29congenital syphilis10.4
30congenital dyserythropoietic anemia10.3
31cerebritis10.3
32polyhydramnios10.3
33hepatitis a10.3
34mediastinitis10.3
35neonatal anemia10.3
36diastolic heart failure10.3
37niemann-pick disease10.2
38sly syndrome10.2
39congenital hypothyroidism10.2
40hereditary lymphedema10.2
41hemochromatosis10.2
42endocardial fibroelastosis10.2
43tetralogy of fallot10.2
44achondrogenesis type ib10.2
45cervicitis10.2
46communicating hydrocephalus10.2
47congenital mesoblastic nephroma10.2
48hemangioma10.2
49histiocytosis10.2
50hydrocephalus10.2

Graphical network of the top 20 diseases related to Hydrops Fetalis:



Diseases related to hydrops fetalis

Clinical Features for Hydrops Fetalis

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

236750

Symptoms:

48
  • hydrops fetalis

Drugs & Therapeutics for Hydrops Fetalis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hydrops Fetalis

Drug clinical trials:

Search ClinicalTrials for Hydrops Fetalis

Search NIH Clinical Center for Hydrops Fetalis

Search CenterWatch for Hydrops Fetalis

Genetic Tests for Hydrops Fetalis

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22GTR
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Genetic tests related to Hydrops Fetalis:

id Genetic test Affiliating Genes
1 Hydrops Fetalis22

Anatomical Context for Hydrops Fetalis

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32MalaCards
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MalaCards organs/tissues related to Hydrops Fetalis:

32
Lung, Heart

Animal Models for Hydrops Fetalis or affiliated genes

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36MGI
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Publications for Hydrops Fetalis

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Genetic Variations for Hydrops Fetalis

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Expression for genes affiliated with Hydrops Fetalis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hydrops Fetalis

Search GEO for disease gene expression data for Hydrops Fetalis.

Pathways for genes affiliated with Hydrops Fetalis

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Sources:
29KEGG, 53Reactome
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Compounds for genes affiliated with Hydrops Fetalis

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Sources:
44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Hydrops Fetalis according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
14-methylumbelliferone4410.5GUSB, NEU1
2cellulose acetate4410.4GPI, HBA2, NEU1
323-diphosphoglycerate4410.4HBB, HBA2
4neomycin4410.3GBA, HBB, GUSB
5castanospermine4410.3GBA, NEU1
6glucose 6-phosphate44 2411.2HBB, TALDO1, GPI
7fructose-6-phosphate44 1111.2GPI, TALDO1
8fructose-1,6-bisphosphate4410.2GPI, TALDO1
9polyacrylamide4410.2NEU1, RHD, HBB, GPI
10mannose4410.1PMM2, NEU1, GBA, ALG1
11glyceraldehyde 3-phosphate4410.1RHD, HBB, TALDO1, GPI
12histidine4410.1PRF1, HBB, TALDO1, GPI
13mannose 6-phosphate44 2411.1GPI, GBA, NEU1, GUSB, PMM2
14galactose4410.1NEU1, RHD, GBA
15methionine4410.0PTPN11, HBB, HBA2, RHD
16adenylate4410.0GPI, GBA, HBB, HBA2, RHD
17h2o2449.8PTPN11, TALDO1, HBB, RHD, NEU1
18oxygen44 2410.7FLT4, RHD, HBA2, HBB, GBA, TALDO1
19glucose449.7FOXC2, RHD, GBA, TALDO1, GPI, PTPN11
20serine449.5NEU1, RHD, HBB, GBA, GPI, PTPN11
21oligonucleotide449.4HBZ, HBA2, HBB, GPC3, PTPN11

GO Terms for genes affiliated with Hydrops Fetalis

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16Gene Ontology
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Cellular components related to Hydrops Fetalis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.2HBB, HBA2
2haptoglobin-hemoglobin complexGO:0318389.9HBB, HBA2
3lysosomal lumenGO:0432029.8GUSB, NEU1, GBA, GPC3
4hemoglobin complexGO:0058339.7HBE1, HBB, HBA2, HBZ

Biological processes related to Hydrops Fetalis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:01567110.3HBB, HBA2
2hydrogen peroxide catabolic processGO:04274410.2HBB, HBA2
3lymphangiogenesisGO:00194610.2FLT4, FOXC2
4regulation of blood vessel sizeGO:05088010.1FOXC2, HBB
5positive regulation of cell deathGO:0109429.9HBB, HBA2
6carbohydrate metabolic processGO:0059759.9GUSB, GBA, TALDO1, GPI, GPC3
7small molecule metabolic processGO:0442819.5GPC3, GUSB, NEU1, HBA2, HBB, GBA

Molecular functions related to Hydrops Fetalis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:03172010.2HBB, HBA2
2peroxidase activityGO:00460110.2HBB, HBA2
3oxygen transporter activityGO:0053449.9HBE1, HBB, HBA2, HBZ
4oxygen bindingGO:0198259.8HBZ, HBA2, HBB, HBE1
5heme bindingGO:0200379.6HBZ, HBA2, HBB, HBE1
6iron ion bindingGO:0055069.4HBE1, HBB, HBA2, HBZ

Products for genes affiliated with Hydrops Fetalis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hydrops Fetalis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet