MCID: HYD012
MIFTS: 45

Hydrops Fetalis malady

Categories: Genetic diseases, Rare diseases, Fetal diseases, Immune diseases

Aliases & Classifications for Hydrops Fetalis

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Aliases & Descriptions for Hydrops Fetalis:

Name: Hydrops Fetalis 46 25 48 66
Hydrops Fetalis Nonimmune 46 25
Familial Non-Immune Hydrops Fetalis 46
 
Hydrops Fetalis, Non-Immune 66
Idiopathic Hydrops Fetalis 46

Classifications:



External Ids:

ICD1028 P56, P56.0, P56.9

Summaries for Hydrops Fetalis

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NIH Rare Diseases:46 Hydrops fetalis is a serious condition in which abnormal amounts of fluid build up in two or more body areas of a fetus or newborn. there are two types of hydrops fetalis: immune and nonimmune. immune hydrops fetalis is a complication of a severe form of rh incompatibility. rh compatibility causes massive red blood cell destruction, which leads to several problems, including total body swelling. severe swelling can interfere with how the body organs work. nonimmune hydrops fetalis occurs when a disease or medical condition disrupts the body's ability to manage fluid. there are three main causes for this type: heart or lung problems, severe anemia (thalassemia), and genetic defects, including turner syndrome. the exact cause depends on which form a baby has. last updated: 1/25/2012

MalaCards based summary: Hydrops Fetalis, also known as hydrops fetalis nonimmune, is related to hepatitis and hydrops fetalis, nonimmune, and has symptoms including joint swelling, joint swelling and fetal tachycardia. An important gene associated with Hydrops Fetalis is NEU1 (Neuraminidase 1), and among its related pathways are Lysosome and Glycosaminoglycan metabolism. Affiliated tissues include heart, lung and placenta, and related mouse phenotype homeostasis/metabolism.

Wikipedia:69 Hydrops fetalis is a condition in the fetus characterized by an accumulation of fluid, or edema, in at... more...

Related Diseases for Hydrops Fetalis

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Diseases related to Hydrops Fetalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.2GPI, HBA1
2hydrops fetalis, nonimmune12.7
3immune hydrops fetalis12.5
4hydrops fetalis anemia immune disorder absent thumb12.2
5fetal edema11.5
6semmekrot haraldsson weemaes syndrome11.2
7mucopolysaccharidosis vii10.8
8pyruvate kinase deficiency10.7
9glucose phosphate isomerase deficiency10.6
10thalassemia10.5
11chorioangioma10.4
12teratoma10.4
13mucopolysaccharidosis10.3
14lysosomal storage disease10.3
15hemoglobin h disease, nondeletional10.3
16hemophagocytic lymphohistiocytosis10.2
17down syndrome10.2
18syphilis10.2
19pulmonary sequestration10.2
20diamond-blackfan anemia10.1
21lymphedema10.1
22cerebritis10.1
23mediastinitis10.1
24congenital syphilis10.1
25cardiomyopathy10.1
26gaucher disease, perinatal lethal10.1
27greenberg skeletal dysplasia10.1
28chondrodysplasia, blomstrand type10.1
29porphyria, congenital erythropoietic10.1
30achondrogenesis, type ii or hypochondrogenesis10.1
31thalassemias, alpha-10.1
32short-rib thoracic dysplasia 1210.1
33hypochondrogenesis10.1
34fetal parvovirus syndrome10.1
35endocardial fibroelastosis10.1
36sacrococcygeal teratoma10.1
37congenital dyserythropoietic anemia10.1
38hemoglobinopathy10.1
39polyhydramnios10.1
40herpes simplex10.1
41cytomegalovirus infection10.1
42tetralogy of fallot10.0
43galactosialidosis10.0
44hemochromatosis10.0
45ebstein anomaly10.0
46hemangioma10.0
47hydrocephalus10.0
48leukemia10.0
49congenital hypothyroidism10.0
50oligohydramnios10.0

Graphical network of the top 20 diseases related to Hydrops Fetalis:



Diseases related to hydrops fetalis

Symptoms for Hydrops Fetalis

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UMLS symptoms related to Hydrops Fetalis:


joint swelling, fetal tachycardia, fetal bradycardia

Drugs & Therapeutics for Hydrops Fetalis

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Drugs for Hydrops Fetalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1glucocorticoidsPhase 1, Phase 24756
2Betamethasone ValeratePhase 1, Phase 21652152-44-5
3
BetamethasonePhase 1, Phase 2165378-44-99782
Synonyms:
.beta.-Methasone
.beta.-Methasone alcohol
1,4-Pregnadiene-3,20-dione-9alpha-fluoro-16 beta-methyl-11 beta,17alpha,21-triol
16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione
16β-Methyl-1,4-pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione
24024-03-1
34166_FLUKA
34166_RIEDEL
378-44-9
4-08-00-03501 (Beilstein Handbook Reference)
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
9-Fluoro-16.beta.-methylprednisolone
9-Fluoro-16beta-methylprednisolone
9-Fluoro-16β-methylprednisolone
9-alpha-Fluoro-16-beta-methylprednisolone
9.alpha.-Fluoro-16.beta.-methylprednisolone
9alpha-Fluoro-16 beta-methyl-prednisolone
9alpha-Fluoro-16beta-methylprednisolone
9α-Fluoro-16β-methylprednisolone
AC1L1EYE
AC1L1TT4
AC1Q5HJZ
AKOS001582690
AR-1A7284
AR-1H5595
B1837
B7005_SIAL
B7005_SIGMA
B9675_SIAL
BIDD:PXR0047
BPBio1_000533
BRD-A35108200-001-04-7
BRD-K39188321-001-03-9
BRN 3176546
BSPBio_000483
Bebate
Becort
Bedifos
Betacorlan
Betacortril
Betadexamethasone
Betafluorene
Betamamallet
Betametasona
Betametasona [INN-Spanish]
Betametasone
Betametasone [DCIT]
Betamethasone
Betamethasone (JP15/USP/INN)
Betamethasone Base
Betamethasone Valearate
Betamethasone [USAN:BAN:INN:JAN]
Betamethasone [USAN:INN:BAN:JAN]
Betamethasone alcohol
Betamethasone cream
Betamethasonum
Betamethasonum [INN-Latin]
Betamethasonvalerat Mikron
Betamethazone
Betapredol
Betasolon
Betnelan
 
Betsolan
C22H29FO5
CHEBI:3077
CHEMBL632
CID3003
CID9782
CPD000339803
Celestene
Celeston
Celestona
Celestone
Celestone Syrup and Tablets
Celestone, Betadexamethasone, Flubenisolone, Sch-4831, NCS-39470, Betamethasone
Cellestoderm
Cidoten
D00244
D1961
DB00443
Desacort-Beta
EINECS 206-825-4
Flubenisolone
HMS1569I05
HSDB 3015
Hormezon
I06-0121
KST-1A3042
LS-118466
LT00441022
Luxiq
Luxiqo
MLS-0310139.0001
MLS000686794
MLS000859943
MLS001066413
MLS001332616
MLS002153244
Methazon
MolPort-003-845-025
MolPort-007-981-051
NCGC00164401-01
NCGC00164401-02
NSC 39470
NSC-39470
NSC39470
Prestwick0_000362
Prestwick1_000362
Prestwick2_000362
Prestwick3_000362
Prestwick_703
Rinderon
Rinderon (TN)
Rinderon A
S1500_Selleck
SAM002589959
SCH 4831
SCH-4831
SMP1_000043
SMR000058601
SMR000339803
SPBio_002404
UNII-9842X06Q6M
Valisone
Visubeta
ZINC03876136
beta-Methasone
beta-Methasone alcohol
betamethasone

Interventional clinical trials:

idNameStatusNCT IDPhase
1Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)TerminatedNCT00670956Phase 1, Phase 2
2Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGRTerminatedNCT00143039Phase 1

Search NIH Clinical Center for Hydrops Fetalis

Genetic Tests for Hydrops Fetalis

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Genetic tests related to Hydrops Fetalis:

id Genetic test Affiliating Genes
1 Hydrops Fetalis25
2 Nonimmune Hydrops Fetalis25

Anatomical Context for Hydrops Fetalis

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MalaCards organs/tissues related to Hydrops Fetalis:

34
Heart, Lung, Placenta, Brain, Bone, Testes, Endothelial

Animal Models for Hydrops Fetalis or affiliated genes

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MGI Mouse Phenotypes related to Hydrops Fetalis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7GBE1, GPI, GUSB, NEU1, PIEZO1

Publications for Hydrops Fetalis

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Articles related to Hydrops Fetalis:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. (26914330)
2016
2
Society for maternal-fetal medicine (SMFM) clinical guideline #7: nonimmune hydrops fetalis. (25557883)
2015
3
Nonimmune hydrops fetalis with ebstein anomaly. (25148508)
2014
4
Staged pacemaker implantation in a preterm with hydrops fetalis due to complete heart block. (23626451)
2013
5
Reply-nonimmune hydrops fetalis and lysosomal storage diseases. (24120156)
2013
6
Adrenal cytomegaly is a frequent pathologic finding in hemoglobin bart hydrops fetalis. (22257311)
2012
7
Intrauterine blood transfusion in immune hydrops fetalis, corrects middle cerebral artery Doppler velocimetry very quickly. (22364302)
2012
8
CCBE1 mutations can cause a mild, atypical form of generalized lymphatic dysplasia but are not a common cause of non-immune hydrops fetalis. (22239599)
2012
9
Venous Doppler studies in low-output and high-output hydrops fetalis. (20684946)
2010
10
Homozygosity for the Mediterranean a-thalassemic deletion (hemoglobin Barts hydrops fetalis). (20220267)
2010
11
Transfusion medicine illustrated: Intrauterine transfusion for homozygous alpha(0) thalassemia reverses hydrops fetalis. (19638154)
2009
12
Prenatal diagnosis of hemoglobin Bart's hydrops fetalis with gap-PCR system. (19816007)
2009
13
Atrial hemangioma: a rare cause of hydrops fetalis and intrauterine fetal death. (16621228)
2007
14
Prenatal diagnosis of partial trisomy 1q and monosomy X in a fetus with a congenital lung lesion and hydrops fetalis. (17431907)
2007
15
Microsatellite markers within --SEA breakpoints for prenatal diagnosis of HbBarts hydrops fetalis. (17158194)
2007
16
Second-trimester diagnosis of mucopolysaccharidosis type IV a presenting as hydrops fetalis. (16865740)
2006
17
Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. (16537897)
2006
18
Hemoglobin H hydrops fetalis syndrome resulting from the association of the - -SEA deletion and the alphaQuong Szealpha mutation in a Chinese woman. (16104884)
2005
19
Sonographic features of Ebstein anomaly associated with hydrops fetalis: a report of two cases. (15756659)
2005
20
Alpha-thalassemia: Hb H disease and Hb Barts hydrops fetalis. (16339648)
2005
21
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia. (15211660)
2004
22
Pathologic quiz case: a 5-day-old boy with hydrops fetalis. Mucolipidoses I (Sialidosis III). (12873188)
2003
23
Value of autopsy in nonimmune hydrops fetalis: series of 51 stillborn fetuses. (12016530)
2002
24
Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection. (10770616)
2000
25
Identification of Gaucher cells in the chorionic villi associated with recurrent hydrops fetalis. (10833378)
2000
26
Investigation of nonimmune hydrops fetalis: multidisciplinary studies are necessary for diagnosis--review of 94 cases. (10441620)
1999
27
Nonimmune hydrops fetalis. (10818859)
1999
28
Three-dimensional sonographic features of Hydrops fetalis. (10545740)
1999
29
Hydrops fetalis caused by alpha-thalassemia: an emerging health care problem. (9516118)
1998
30
Familial non-immune hydrops fetalis and congenital pulmonary lymphangiectasia. (9667408)
1998
31
Mucopolysaccharidosis type VII associated with hydrops fetalis: histopathological and ultrastructural features with genetic implications. (9155679)
1997
32
Second-trimester hydrops fetalis in pregnancies affected by homozygous alpha-thalassaemia-1. (9110371)
1997
33
Human parvovirus B19 infection associated with hydrops fetalis. (9325515)
1997
34
Diagnosis and management of early non-immune hydrops fetalis. (9509544)
1997
35
A severe transfusion-dependent congenital dyserythropoietic anaemia presenting as hydrops fetalis. (9054660)
1997
36
A case of hydrops fetalis, probably due to antibodies directed against antigenic determinants of GP.Mur (Miltenberger class III) cells. (15387736)
1996
37
Antenatal human parvovirus B19 infection and nonimmune hydrops fetalis presenting as severe preeclampsia. (8883769)
1996
38
Prognostic factors and prenatal management in non immune hydrops fetalis are still a dilemma. (8950726)
1996
39
Hematologic disorders and nonimmune hydrops fetalis. (8822334)
1995
40
Agenesis of the ductus venosus and its correlation to hydrops fetalis and the fetal hepatic circulation: case reports and review of the literature. (8736596)
1995
41
Cardiac abnormalities associated with hydrops fetalis. (8822332)
1995
42
Immunohistochemical distribution of surfactant apoproteins in hypoplastic lungs of nonimmunologic hydrops fetalis. (7590701)
1995
43
Non-immunological hydrops fetalis and intrapericardial teratoma: case report and review. (8559758)
1995
44
Osteopenia, abnormal dentition, hydrops fetalis and communicating hydrocephalus. (8591675)
1995
45
Four cases of absent ductus venosus: three in combination with severe hydrops fetalis. (7880437)
1994
46
Nonimmune hydrops fetalis associated with maternal infection with syphilis. (1442955)
1992
47
Intrauterine transfusion treatment of nonimmune hydrops fetalis secondary to human parvovirus B19 infection. (1849704)
1991
48
Clinico-pathological findings in non-immune hydrops fetalis. (1817125)
1991
49
Nonimmune hydrops fetalis associated with genetic abnormalities. (2406672)
1990
50
Hydrops fetalis from B19 parvovirus infection. (2177495)
1990

Variations for Hydrops Fetalis

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Clinvar genetic disease variations for Hydrops Fetalis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NEU1NM_000434.3(NEU1): c.353-2A> Gsingle nucleotide variantPathogenicrs864309513GRCh37Chr 6, 31829229: 31829229
2NEU1NM_000434.3(NEU1): c.1170C> G (p.Tyr390Ter)single nucleotide variantPathogenicrs746607723GRCh38Chr 6, 31859797: 31859797
3GUSBNM_000181.3(GUSB): c.1144C> T (p.Arg382Cys)single nucleotide variantLikely pathogenic, Pathogenicrs121918173GRCh37Chr 7, 65439613: 65439613
4GUSBNM_000181.3(GUSB): c.1069C> T (p.Arg357Ter)single nucleotide variantLikely pathogenic, Pathogenicrs121918185GRCh37Chr 7, 65439688: 65439688

Expression for genes affiliated with Hydrops Fetalis

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Search GEO for disease gene expression data for Hydrops Fetalis.

Pathways for genes affiliated with Hydrops Fetalis

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GO Terms for genes affiliated with Hydrops Fetalis

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Cellular components related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:004320210.0GUSB, NEU1
2extracellular exosomeGO:00700627.6GBE1, GPI, GUSB, HBA1, NEU1

Biological processes related to Hydrops Fetalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate metabolic processGO:00059759.5GPI, GUSB

Sources for Hydrops Fetalis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet