HIDS
MCID: HYP088
MIFTS: 59

Hyper-Igd Syndrome (HIDS) malady

Genetic diseases, Rare diseases, Bone diseases, Skin diseases, Metabolic diseases, Blood diseases categories
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Summaries for Hyper-Igd Syndrome

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NIH Rare Diseases:42 Hyper igd syndrome is an inflammatory genetic disorder characterized by periodic episodes of fever associated with additional symptoms including joint pain, skin rash and abdominal pain. most episodes last several days and occur periodically throughout life. the frequency of episodes and their severity vary greatly from case to case.  hyper igd syndrome is caused by mutations in the gene encoding mevalonate kinase (mvk). it is inherited in an autosomal recessive manner.  last updated: 3/5/2013

MalaCards based summary: Hyper-Igd Syndrome, also known as hyper igd syndrome, is related to mevalonic aciduria and familial mediterranean fever, and has symptoms including acute abdominal pain/colic, gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia and hepatomegaly/liver enlargement (excluding storage disease). An important gene associated with Hyper-Igd Syndrome is MVK (mevalonate kinase), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Jak/Stat Pathway. The compounds toxin-1 and amphotericin b have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are reproductive system and immune system.

Description from OMIM:46 260920

Aliases & Classifications for Hyper-Igd Syndrome

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Sources:
42NIH Rare Diseases, 46OMIM, 44Novoseek, 48Orphanet, 20GeneTests, 62UMLS, 26ICD10 via Orphanet
See all sources

Hyper-Igd Syndrome, Aliases & Descriptions:

Name: Hyper-Igd Syndrome 42 46 44 48
Hyper Igd Syndrome 42 20
Hyperimmunoglobulinemia D and Periodic Fever Syndrome 42
Hyperimmunoglobulinemia D with Periodic Fever 48
Hyperimmunoglobinemia D with Recurrent Fever 48
 
Partial Mevalonate Kinase Deficiency 48
Hyperimmunoglobulinemia D Syndrome 48
Periodic Fever Dutch Type 42
Hyperimmunoglobulinemia D 62
Hids 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
hyper-igd syndrome:
Inheritance: Autosomal recessive; Age of onset: Neonatal/infancy


External Ids:

OMIM46 260920
ICD10 via Orphanet26 E85.0

Related Diseases for Hyper-Igd Syndrome

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Diseases related to Hyper-Igd Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1mevalonic aciduria31.2MVK, IL1RN
2familial mediterranean fever30.6TNF, TNFRSF1A
3amyloidosis30.4TNFRSF1A, SAA1, CRP
4schnitzler syndrome10.5IL1RN
5dengue shock syndrome10.5IL1RN
6malaria10.4TNF
7muckle-wells syndrome10.4TNFRSF1A
8leishmaniasis10.3TNFRSF1A
9epidural abscess10.3CRP
10systemic lupus erythematosus10.3CRP
11adult-onset still's disease10.3CRP
12kid syndrome10.3
13rheumatic disease10.3CRP
14blau syndrome10.3MVK, TNF
15glomerulonephritis10.2
16keratopathy10.2
17crescentic glomerulonephritis10.2
18pericarditis10.2
19acute graft versus host disease10.2TNF, IL1RN
20cerebral malaria10.2IL1RN, TNF
21toxic shock syndrome10.2IL1RN, TNF
22relapsing fever10.2TNFRSF1A, MVK
23adult respiratory distress syndrome10.2TNF, IL1RN
24ichthyosis, hystrix-like, with deafness10.2
25periodontitis10.2IL1RN, TNF
26arthritis10.1TNFRSF1A, TNF
27polymyalgia rheumatica10.1IL1RN, CRP
28exanthem10.1IL1RN, CRP
29spondylarthropathy10.1CRP, TNF
30amyloidosis, secondary10.1CRP, SAA1
31chronic infantile neurological cutaneous articular syndrome10.1MVK, IL1RN, TNFRSF1A
32colitis10.1IL1RN, TNF
33graft versus host disease10.1TNF, TNFRSF1A
34cryopyrin-associated periodic syndrome10.0
35inflammatory bowel disease10.0IL1RN, TNFRSF1A
36uveitis10.0TNF, TNFRSF1A
37ankylosing spondylitis10.0CRP, TNF
38monocytic leukemia10.0TNF, TNFRSF1A
39psoriatic arthritis10.0CRP, TNF
40neutropenia10.0IL1RN, TNFRSF1A
41respiratory failure10.0CRP, TNF
42periodic fever, familial, autosomal dominant10.0TNFRSF1A, MVK, TNF
43behcet's disease10.0TNF, CRP
44periodontal disease10.0CRP, TNF
45ulcerative colitis10.0TNF, CRP
46vascular disease10.0IL1RN, TNFRSF1A, TNF
47crohn's disease10.0TNF, CRP
48hypersensitivity reaction type ii disease10.0TNF, IL1RN, TNFRSF1A
49acute pancreatitis10.0IL1RN, CRP
50peritonitis10.0CRP, TNF

Graphical network of the top 20 diseases related to Hyper-Igd Syndrome:



Diseases related to hyper-igd syndrome

Symptoms for Hyper-Igd Syndrome

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Symptoms by clinical synopsis from OMIM:

260920

Clinical features from OMIM:

260920

Symptoms:

48 (show all 28)
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hepatomegaly/liver enlargement (excluding storage disease)
  • lymphadenopathy/polyadenopathies
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • autosomal recessive inheritance
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • urticaria
  • follicular/erythematous/edematous papules/milium
  • enanthema/aphtosa/aphta/leukoplakia
  • dermal/subcutaneous infiltration/induration
  • acute diarrhea
  • vascularitis/vasculitides/arteritis
  • facial pain/cephalalgia/migraine
  • arthritis/synovitis/synovial proliferation
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • purpura/petichiae
  • intestinal obstruction/ileus
  • peritonitis/peritoneal abscess
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • ataxia/incoordination/trouble of the equilibrium
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • restricted joint mobility/joint stiffness/ankylosis
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • failure to thrive/difficulties for feeding in infancy/growth delay

HPO human phenotypes related to Hyper-Igd Syndrome:

(show all 40)
id Description Frequency HPO Source Accession
1 abdominal pain hallmark (90%) HP:0002027
2 gastrointestinal hemorrhage hallmark (90%) HP:0002239
3 hepatomegaly hallmark (90%) HP:0002240
4 lymphadenopathy hallmark (90%) HP:0002716
5 arthralgia hallmark (90%) HP:0002829
6 myalgia hallmark (90%) HP:0003326
7 abnormality of temperature regulation hallmark (90%) HP:0004370
8 abnormality of the oral cavity typical (50%) HP:0000163
9 urticaria typical (50%) HP:0001025
10 arthritis typical (50%) HP:0001369
11 diarrhea typical (50%) HP:0002014
12 migraine typical (50%) HP:0002076
13 vasculitis typical (50%) HP:0002633
14 acrocyanosis occasional (7.5%) HP:0001063
15 seizures occasional (7.5%) HP:0001250
16 limitation of joint mobility occasional (7.5%) HP:0001376
17 subcutaneous hemorrhage occasional (7.5%) HP:0001933
18 incoordination occasional (7.5%) HP:0002311
19 peritonitis occasional (7.5%) HP:0002586
20 intestinal obstruction occasional (7.5%) HP:0005214
21 abnormal immunoglobulin level occasional (7.5%) HP:0010701
22 cognitive impairment occasional (7.5%) HP:0100543
23 retinitis pigmentosa rare (5%) HP:0000510
24 autosomal recessive inheritance HP:0000007
25 optic disc pallor HP:0000543
26 night blindness HP:0000662
27 skin rash HP:0000988
28 hypermelanotic macule HP:0001034
29 arthritis HP:0001369
30 splenomegaly HP:0001744
31 leukocytosis HP:0001974
32 vomiting HP:0002013
33 diarrhea HP:0002014
34 abdominal pain HP:0002027
35 headache HP:0002315
36 vertigo HP:0002321
37 lymphadenopathy HP:0002716
38 arthralgia HP:0002829
39 increased iga level HP:0003261
40 elevated erythrocyte sedimentation rate HP:0003565

Drugs & Therapeutics for Hyper-Igd Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Hyper-Igd Syndrome

Genetic Tests for Hyper-Igd Syndrome

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Genetic tests related to Hyper-Igd Syndrome:

id Genetic test Affiliating Genes
1 Hyper Igd Syndrome20 MVK

Anatomical Context for Hyper-Igd Syndrome

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MalaCards organs/tissues related to Hyper-Igd Syndrome:

32
Skin, Bone, Liver, Monocytes

Animal Models for Hyper-Igd Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hyper-Igd Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2IL1RN, PTX3, TNFRSF1A, TNF
2MP:00053877.5CRP, IL1RN, PTX3, TNFRSF1A, TNF
3MP:00053767.3TNF, TNFRSF1A, SAA1, IL1RN, CRP

Publications for Hyper-Igd Syndrome

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Articles related to Hyper-Igd Syndrome:

(show all 31)
idTitleAuthorsYear
1
Long chain fatty acid (Lcfa) abnormalities in hyper Igd syndrome (Hids) and Familial Mediterranean Fever (Fmf): new insight into heritable periodic fevers. (23375471)
2013
2
Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS). (21607759)
2012
3
Renal amyloidosis due to hyper-IgD syndrome. (23169386)
2012
4
Mevalonate kinase deficiency (hyper IgD syndrome with periodic fever)--different faces with separate treatments: two cases and review of the literature. (23692791)
2012
5
Hyper-IgD syndrome or mevalonate kinase deficiency. (21760510)
2011
6
A novel mutation in TNFRSF1A associated with overlapping features of tumor necrosis factor receptor-associated periodic syndrome and hyper-IgD syndrome. (20346247)
2010
7
Nummular keratopathy in a patient with Hyper-IgD Syndrome. (19656398)
2009
8
Recurrent pericarditis in hyper-IgD syndrome. (19772809)
2009
9
Hyper-IgD syndrome with novel mutation in a Japanese girl. (18941711)
2009
10
A patient with hyper-IgD syndrome responding to simvastatin treatment. (19046710)
2008
11
MVK gene abnormality and new approach to treatment of hyper IgD syndrome and periodic fever syndrome]. (17473510)
2007
12
Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. (18008182)
2007
13
Diagnostic value of serum immunoglobulinaemia D level in patients with a clinical suspicion of hyper IgD syndrome. (17804452)
2007
14
A patient with hyper-IgD syndrome responding to anti-TNF treatment. (17171314)
2007
15
Diagnostic challenge of hyper-IgD syndrome in four children with inflammatory gastrointestinal complaints. (16635911)
2006
16
Hereditary periodic fever with systemic amyloidosis: is hyper-IgD syndrome really a benign disease? (16931207)
2006
17
Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome. (16011988)
2005
18
Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model. (16093577)
2005
19
A patient with hyper-IgD syndrome in Antalya, Turkey. (15045637)
2004
20
Inefficacy of etanercept in a child with hyper-IgD syndrome and periodic fever. (15638064)
2004
21
Effect of inflammatory attacks in the classical type hyper-IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response. (15324368)
2004
22
Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. (12452839)
2002
23
Mevalonic aciduria and hyper-IgD syndrome: two sides of the same coin? (11486910)
2001
24
Non-steroidal anti-inflammatory drugs in the treatment of hyper-IgD syndrome. (11534513)
2001
25
Identification of the gene for hyper-IgD syndrome: a model of modern genetics]. (10800545)
2000
26
Hyper-IgD syndrome and familial Hibernian fever are true periodic fever syndromes. (10969277)
2000
27
Crescentic glomerulonephritis in hyper IgD syndrome. (10229000)
1999
28
Hyper-IgD syndrome and pregnancy. (8886712)
1996
29
Unstimulated peripheral blood mononuclear cells from patients with the hyper-IgD syndrome produce cytokines capable of potent induction of C-reactive protein and serum amyloid A in Hep3B cells. (8683144)
1996
30
Clinical and immunological follow-up in children with hyper-IgD syndrome. (8167736)
1993
31
Hyper-IGD syndrome: a new case treated with colchicine. (3229086)
1988

Variations for Hyper-Igd Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Hyper-Igd Syndrome:

64 (show all 21)
id Symbol AA change Variation ID SNP ID
1MVKp.His20ProVAR_004022
2MVKp.Pro167LeuVAR_004023
3MVKp.Ile268ThrVAR_004024
4MVKp.Val377IleVAR_004027rs28934897
5MVKp.Val310MetVAR_009068
6MVKp.His20AsnVAR_010956rs11544299
7MVKp.Leu39ProVAR_010957
8MVKp.Ser135LeuVAR_010959
9MVKp.Ala148ThrVAR_010960
10MVKp.Ser150LeuVAR_010961
11MVKp.Gly202ArgVAR_010962
12MVKp.Arg215GlnVAR_010963
13MVKp.Gly309SerVAR_010967
14MVKp.Gly326ArgVAR_010968
15MVKp.His20GlnVAR_029519
16MVKp.Val132IleVAR_029520
17MVKp.Gly171ArgVAR_029521
18MVKp.Gly211GluVAR_029522
19MVKp.Val250IleVAR_029523
20MVKp.Leu265ArgVAR_029524
21MVKp.Gly376ValVAR_029527

Clinvar genetic disease variations for Hyper-Igd Syndrome:

6 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1MVKNM_000431.3(MVK): c.1129G> A (p.Val377Ile)single nucleotide variantPathogenicrs28934897GRCh37Chr 12, 110034320: 110034320
2MVKNM_000431.3(MVK): c.1000G> A (p.Ala334Thr)single nucleotide variantPathogenicrs104895317GRCh37Chr 12, 110032947: 110032947
3MVKNM_000431.3(MVK): c.59A> C (p.His20Pro)single nucleotide variantPathogenicrs104895295GRCh37Chr 12, 110012686: 110012686
4MVKNM_000431.3(MVK): c.803T> C (p.Ile268Thr)single nucleotide variantPathogenicrs104895304GRCh37Chr 12, 110029080: 110029080
5MVKNM_000431.3(MVK): c.494C> T (p.Pro165Leu)single nucleotide variantPathogenicrs121917790GRCh37Chr 12, 110019322: 110019322
6MVKNM_000431.3(MVK): c.928G> A (p.Val310Met)single nucleotide variantPathogenicrs104895319GRCh37Chr 12, 110032875: 110032875
7MVKNM_000431.3(MVK): c.500C> T (p.Pro167Leu)single nucleotide variantPathogenicrs104895300GRCh37Chr 12, 110019328: 110019328
8MVKNM_000431.3(MVK): c.604G> A (p.Gly202Arg)single nucleotide variantPathogenicrs104895301GRCh37Chr 12, 110023903: 110023903
9MVKNM_000431.3(MVK): c.417dupC (p.Gly140Argfs)duplicationPathogenicrs104895373GRCh37Chr 12, 110019245: 110019246
10MVKNM_000431.3(MVK): c.72dupT (p.Gly25Trpfs)duplicationPathogenicrs104895322GRCh37Chr 12, 110012699: 110012700
11MVKNM_000431.3(MVK): c.421dupG (p.Ala141Glyfs)duplicationPathogenicrs104895323GRCh37Chr 12, 110019249: 110019250

Expression for genes affiliated with Hyper-Igd Syndrome

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Expression patterns in normal tissues for genes affiliated with Hyper-Igd Syndrome

Search GEO for disease gene expression data for Hyper-Igd Syndrome.

Pathways for genes affiliated with Hyper-Igd Syndrome

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Pathways related to Hyper-Igd Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFRSF1A
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.4CRP, IL1RN
3
Show member pathways
9.2SAA1, TNF
4
Show member pathways
9.1TNF, TNFRSF1A
5
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.1TNFRSF1A, TNF
69.1TNF, TNFRSF1A
7
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.1TNFRSF1A, TNF
8
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1TNFRSF1A, TNF
99.1TNFRSF1A, TNF
109.1TNF, TNFRSF1A
119.1TNFRSF1A, TNF
12
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.1TNF, TNFRSF1A
13
Show member pathways
9.1TNFRSF1A, TNF
149.1TNF, TNFRSF1A
15
Show member pathways
9.1TNFRSF1A, TNF
16
Show member pathways
9.1TNF, TNFRSF1A
179.1TNF, TNFRSF1A
189.1TNFRSF1A, TNF
199.1TNF, TNFRSF1A
20
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.1TNFRSF1A, TNF
21
Show member pathways
thioredoxin pathway37
8.6CRP, SAA1, TNF

Compounds for genes affiliated with Hyper-Igd Syndrome

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Compounds related to Hyper-Igd Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1toxin-1449.5TNF, IL1RN
2amphotericin b449.4IL1RN, CRP
3bcma449.4TNFRSF1A, TNF
4tocilizumab44 1110.4CRP, TNF
5gold sodium thiomalate449.4IL1RN, TNF
6blys449.4TNF, TNFRSF1A
7cdp571449.4TNF, CRP
8actinomycin449.3TNFRSF1A, TNF
9gabexate mesilate449.3TNF, CRP
10hydroxychloroquine44 1110.3TNF, CRP
11polyethylene glycol449.3CRP, IL1RN, TNFRSF1A
12p003449.3CRP, IL1RN, TNFRSF1A
13p002449.3TNFRSF1A, IL1RN, CRP
14tab-1449.2TNFRSF1A, TNF
15leflunomide44 50 1111.1TNF, TNFRSF1A, IL1RN
16ns 39844 6110.1TNF, TNFRSF1A, IL1RN
17manganese superoxide449.1IL1RN, TNFRSF1A, TNF
18chloroquine44 2 50 28 1113.1TNF, TNFRSF1A, IL1RN
19tgf beta1449.0TNF, TNFRSF1A, IL1RN
20nash449.0TNF, TNFRSF1A
21sulfasalazine28 44 50 1112.0CRP, IL1RN, TNF
22fmlp449.0IL1RN, TNFRSF1A, TNF
23tenidap44 2810.0TNF, SAA1, CRP
24atorvastatin44 50 28 24 1113.0TNF, IL1RN, CRP
25rituximab44 50 1111.0TNF, SAA1, CRP
26prednisolone44 28 1111.0TNF, IL1RN, CRP
27rosiglitazone28 44 50 24 1112.9CRP, IL1RN, TNF
28okt3448.9TNF, TNFRSF1A, CRP
29prostacyclin448.8CRP, TNFRSF1A, TNF
30anakinra44 119.7TNF, MVK, IL1RN, CRP
31fibrinogen448.6TNF, SAA1, IL1RN, CRP
32adalimumab44 50 1110.5TNF, TNFRSF1A, IL1RN, CRP
33etanercept44 50 1110.5TNF, TNFRSF1A, IL1RN, CRP
34infliximab44 50 1110.5TNF, TNFRSF1A, IL1RN, CRP
35ivig448.5TNF, TNFRSF1A, IL1RN, CRP
36neopterin448.5CRP, IL1RN, TNFRSF1A, TNF
37methotrexate50 44 1110.5CRP, IL1RN, TNFRSF1A, TNF
38n acetylcysteine448.5CRP, TNFRSF1A, TNF
39sb 20358044 619.5TNF, TNFRSF1A, IL1RN, CRP
40alanine448.5CRP, IL1RN, MVK, SAA1, TNFRSF1A
41creatinine448.5CRP, IL1RN, MVK, PTX3, TNFRSF1A
42rantes448.4IL1RN, TNFRSF1A, TNF
43vegf448.3TNF, TNFRSF1A, IL1RN, CRP
44nitric oxide44 24 1110.3TNF, TNFRSF1A, PTX3, IL1RN
45dexamethasone44 50 28 1111.2TNF, TNFRSF1A, PTX3, SAA1, IL1RN
46endotoxin448.1CRP, IL1RN, SAA1, TNFRSF1A, TNF
47cholesterol44 28 24 1111.0TNFRSF1A, PTX3, SAA1, MVK, IL1RN, CRP
48cycloheximide448.0TNF, TNFRSF1A, PTX3, IL1RN, CRP
49simvastatin44 50 61 28 24 1112.7CRP, IL1RN, MVK, SAA1, TNFRSF1A, TNF
50lipid447.7TNF, TNFRSF1A, SAA1, MVK, IL1RN, CRP

GO Terms for genes affiliated with Hyper-Igd Syndrome

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Cellular components related to Hyper-Igd Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CRP, IL1RN, TNFRSF1A, TNF
2extracellular regionGO:0055767.2CRP, SAA1, PTX3, TNFRSF1A, TNF

Biological processes related to Hyper-Igd Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1opsonizationGO:0082289.6CRP, PTX3
2chronic inflammatory response to antigenic stimulusGO:0024399.5IL1RN, TNF
3positive regulation of JUN kinase activityGO:0435079.4IL1RN, TNF
4negative regulation of inflammatory responseGO:0507289.4TNFRSF1A, SAA1, MVK
5positive regulation of cytokine secretionGO:0507159.4SAA1, TNF
6negative regulation of interleukin-6 productionGO:0327159.4TNF, TNFRSF1A
7response to ethanolGO:0454719.3CRP, TNFRSF1A
8acute-phase responseGO:0069539.3CRP, IL1RN, SAA1
9negative regulation of lipid storageGO:0108889.3CRP, TNF
10positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, PTX3
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.2TNF, TNFRSF1A
12defense response to Gram-positive bacteriumGO:0508309.1CRP, TNF
13intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.1TNFRSF1A, TNF
14negative regulation of gene expressionGO:0106299.0TNFRSF1A, TNF
15response to glucocorticoidGO:0513848.9IL1RN, TNF
16response to hypoxiaGO:0016668.8CRP, TNFRSF1A, TNF
17inflammatory responseGO:0069548.3TNF, TNFRSF1A, PTX3, CRP

Molecular functions related to Hyper-Igd Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.1TNFRSF1A, TNF

Products for genes affiliated with Hyper-Igd Syndrome

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  • Antibodies
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  • Lysates

Sources for Hyper-Igd Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet