Aliases & Classifications for Hyper Ige Syndrome

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Aliases & Descriptions for Hyper Ige Syndrome:

Name: Hyper Ige Syndrome 45
Hyper-Ige Recurrent Infection Syndrome 45
Hyperimmunoglobulin E Syndrome 45
 
Hyper-Ige Syndrome 47
Job Syndrome 65
Hies 45

Classifications:



External Ids:

UMLS65 C3887645

Summaries for Hyper Ige Syndrome

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NIH Rare Diseases:45 Hyper ige syndromes (hies) are rare primary immune deficiencies characterized by elevated serum ige, skin inflammation (dermatitis) and recurrent skin and lung infections. there are two forms of hies, which have the above characteristics in common but otherwise have distinct presentations, courses and outcomes: autosomal dominant hies (ad-hies) and autosomal recessive hies (ar-hies). click on the embedded links to learn more about autosomal dominant hies (or job syndrome) and autosomal recessive hies. last updated: 7/14/2015

MalaCards based summary: Hyper Ige Syndrome, also known as hyper-ige recurrent infection syndrome, is related to his bundle tachycardia and hyper-ige recurrent infection syndrome. An important gene associated with Hyper Ige Syndrome is PGM3 (Phosphoglucomutase 3), and among its related pathways are Jak/STAT Signaling Pathway and Signaling events mediated by PTP1B. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Hyper Ige Syndrome

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Graphical network of the top 20 diseases related to Hyper Ige Syndrome:



Diseases related to hyper ige syndrome

Symptoms for Hyper Ige Syndrome

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Drugs & Therapeutics for Hyper Ige Syndrome

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Drugs for Hyper Ige Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Posaconazoleapproved, investigationalPhase 349171228-49-2147912
Synonyms:
1-((1S,2S)-1-Ethyl-2-hydroxypropyl)-4-{4-[4-(4-{[(5S,3R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazolylmethyl)oxolan-3-yl]methoxy}phenyl)piperazinyl]phenyl}-1,2,4-triazolin-5-one
171228-49-2
177571-33-4
4-(p-(4-(p-(((3R,5R)-5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furyl)methoxy)phenyl)-1-piperazinyl)phenyl)-1-((1S,2S)-1-ethyl-2-hydroxypropyl)-delta(sup 2)-1,2,4-triazolin-5-one
4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
AC-1350
AC1L3W34
AC1LAHLQ
AKOS005145917
CHEBI:434337
CHEMBL1397
CHEMBL371938
CHEMBL371939
CID10532764
CID11520437
CID11542142
CID147912
CID468595
D02555
DB01263
 
HSDB 7421
LS-186118
LS-186988
LS-187630
MolPort-006-666-426
Noxafil
Noxafil (TN)
Noxafil, Posaconazole
Posaconazole
Posaconazole (USAN/INN)
Posaconazole SP
Posaconazole [USAN:INN:BAN]
Posaconazole in combination with MGCD290
Posanol
S1257_Selleck
SCH-56592
SCH56592
SID144207169
Sch 56592
Spriafil
UNII-6TK1G07BHZ
X2N
posaconazole
2
Miconazoleapproved, investigationalPhase 3, Phase 2302622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
3Antifungal AgentsPhase 3, Phase 23015
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 39988
5Hormone AntagonistsPhase 310002
6HormonesPhase 311748
7Cytochrome P-450 Enzyme InhibitorsPhase 33036
8Antiparasitic AgentsPhase 3, Phase 21854
9Anti-Infective AgentsPhase 3, Phase 217220
10Antiprotozoal AgentsPhase 3, Phase 21730
11
Amphotericin Bapproved, investigationalPhase 21171397-89-314956, 5280965
Synonyms:
12633-72-6
1397-89-3
30782-62-8
5-18-10-00525 (Beilstein Handbook Reference)
54482-28-9
8055-20-7
AB00513832
ABLC
AC1L1CN2
AC1L24V6
AC1L70KF
AC1L73U6
AC1NQXTD
AC1NTQ32
AC1NUQG4
AC1NY9JC
AC1O7GCZ
AC1O8FQV
AC1O8PFK
AI3-26528
AMPH-B
AMPH-b
Abelcet
Abelecet
AmBisome (TN)
Ambap1397-89-3
Ambisome
Amfotericina B
Amfotericina B [INN-Spanish]
Ampho-Moronal
Amphocin
Amphomoronal
Amphortericin B
Amphotec
Amphotec (TN)
Amphotericin
Amphotericin .BETA.
Amphotericin B
Amphotericin B (JP15/USP/INN)
Amphotericin B Cholesterol Dispersion
Amphotericin B Cholesteryl Sulfate Complex
Amphotericin B Colloidal Dispersion
Amphotericin B [USAN:INN:JAN]
Amphotericin B, Lipid-based
Amphotericin B, Streptomyces sp.
Amphotericin-B
Amphotericine B
Amphotericine B [INN-French]
Amphotericinum
Amphotericinum B
Amphotericinum B [INN-Latin]
Amphotherizin
Amphotherizin [German]
Amphotéricine B
Amphozone
BIDD:GT0351
BPBio1_000374
BRN 0078342
BSPBio_000340
C-AmB
C06573
C47H73NO17
CCRIS 5963
CHEBI:2682
CHEMBL1200646
CHEMBL267345
CID10533925
CID10629638
CID10677275
CID14956
 
CID1972
CID352546
CID354192
CID5280965
CID5386092
CID5458486
CID5771695
CID6604295
CID6708817
CID6713692
CID9919339
D00203
DB00681
DivK1c_007045
EINECS 215-742-2
Fungilin
Fungisome
Fungisone
Fungizone
Fungizone (TN)
HMS1569A22
HSDB 3008
HSDB 3008 IAB
Halizon
I06-0257
KBio1_001989
KBio2_000551
KBio2_003119
KBio2_005687
KBioGR_002298
KBioSS_000551
LMPK06000002
LNS-AmB
LS-187721
LS-93
Liposomal Amphotericin B
Liposomal amphotericin b
MLS002702966
MolPort-006-392-260
Mysteclin-F
NCGC00014913
NCGC00090808-01
NCGC00098014-01
NCGC00179595-01
NCI527017
NCI60_004288
NCIStruc1_001042
NCIStruc2_000920
NKTR-024
NS 718
NSC 527017
NSC-527017
NSC527017
Prestwick0_000410
Prestwick1_000410
Prestwick2_000410
Prestwick3_000410
Prestwick_721
SMP1_000302
SMR001566780
SPBio_000715
SPBio_002279
ST50999656
SinuNase
SpecPlus_000949
Spectrum2_000818
Spectrum4_001779
Spectrum_000111
UNII-7XU7A7DROE
amophotericin B
amphotericin B liposomal
amphotericin b
12
RanitidineapprovedPhase 27466357-59-3, 66357-35-53001055
Synonyms:
(E)-1-N'-[2-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
(E)-N-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine
(E)-N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine
66357-35-5
66357-59-3 (hydrochloride)
68109-63-7
7 Select Acid Reducer
AC-12712
AC1MHDJB
AC1Q1WQX
AR-1B4779
Achedos
Acid Reducer
Acid Reducer 150
Acid Reducer Maximum Strength
Acid Reducer Regular Strength
Acid Reducer maximum strength
Acid Relief
Acidex
Alquen
Atural
Axoban
BIDD:GT0179
Being Well Heartburn Relief
Being Well Heartburn Relief acid reducer
Biotidin
C13H22N4O3S
CAS-66357-59-3
CHEBI:8776
CHEMBL512
CID3001055
Care One Acid Reducer
Careone Acid Reducer
Cool Mint Acid Reducer
Coralen
Curan
D00422
DB00863
Dg Health Acid Reducer
Dg Health Acid Reducer Maximum Strength
Duractin
EINECS 266-332-5
Equaline Heartburn Relief
Equate Acid Reducer
Equate Ranitidine
Equate Ranitidine Acid Reducer
Exchange Select Acid Reducer
Ezopta
Family Wellness Acid Reducer
Fendibina
Formu Care Ranitidine
Formucare Ranitidine
Gastrial
Gastridina
Gastrolav
Gastrosedol
Good Neighbor Pharmacy Acid Control
Good Neighbor Pharmacy Acid Control 150
Good Neighbor Pharmacy Acid Control 150 Maximum Strength
Good Sense Acid Reducer
HMS1921L07
HMS2092H15
HMS501F22
HSDB 3925
Health Mart Acid Reducer
Healthy Accents Ranitidine
Heartburn Relief
Heartburn Relief Acid Reducer
I09-0405
IDI1_000440
Istomar
KST-1B7387
Kirkland Signature Acid Reducer
Kuracid
L000504
LS-67645
Leader Acid Control
Leader Acid Control Acid Reducer
Leader Acid Control Maximum Strength
Logast
Lopac-R-101
Lopac0_001073
Major Ranitidine Maximum Strength
Mauran
Maximum Strength
Maximum Strength Acid Reducer
Maximum Strength Heartburn Relief
Maximum Strength Heartburn Relief 150
Maximum Strength Ranitidine
Maximum Strength Zantac
Melfax
Microtid
MolPort-003-666-370
N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
NCGC00015876-01
NCGC00015876-02
NCGC00015876-08
 
NCGC00018108-01
NCGC00024387-02
NCGC00094913-01
NCGC00094913-02
NCGC00094913-03
NCGC00094913-04
NCGC00094913-05
Noctone
Non-prescription Strength Acid Reducer
Nu-Ranit
Prestwick2_000201
Ptinolin
Quantor
Quicran
RAN
RND
Radinat
Randin
Rani-Q
Rani-nerton
Raniben
Raniberl
Ranibloc
Ranidine
Ranifur
Ranin
Raniogas
Raniplex
Ranisen
Raniter
Ranitidin
Ranitidina
Ranitidina [INN-Spanish]
Ranitidine
Ranitidine (Form I And Form Ii)
Ranitidine (TN)
Ranitidine (USAN/INN)
Ranitidine 75
Ranitidine Acid Reducer
Ranitidine Base
Ranitidine HCL
Ranitidine HCL 1/2 Type
Ranitidine Hydrochloride
Ranitidine [USAN:BAN:INN]
Ranitidinum
Ranitidinum [INN-Latin]
Ranitiget
Ranitin
Rantacid
Rantidine
Rantidine HCL
Ratic
Raticina
Regular Strength Acid Reducer
Rexall Heartburn Relief
Rx Act Heartburn Relief
SPECTRUM1501151
ST050299
STK619092
Sampep
Shoprite Acid Reducer
Shoprite Acid Reducer Maximum Strength
Smart Sense Acid Reducer
Smart Sense Ranitidine
Sostril
Spectrum5_001189
Sunmark Acid Reducer
Sunmark Acid Reducer Maximum Strength
Taural
Terposen
Tocris-1967
Topcare Heartburn Relief
Topcare Heartburn Relief 150
UNII-884KT10YB7
Ul-Pep
Ulceranin
Ulcex
Ultidine
Urantac
Verlost
Vesyca
Vizerul
Wal Zan 150
Wal Zan 75
Wal Zan Acid Reducer maximum strength
Wal-zan
Weichilin
Weidos
Xanidine
ZANTAC
Zantab
Zantac
Zantac (TN)
Zantac 150 Acid Reducer
Zantac 75
Zantac Maximum Strength 150 Cool Mint
Zantadin
Zantic
ranitidine
13
Histamine PhosphateapprovedPhase 290651-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
EINECS 200-118-4
 
H0147
Histamine Positive Skin Test Control
Histamine Positive skin test control
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
14AutoantibodiesPhase 2117
15Liposomal amphotericin BPhase 2117
16Anti-Bacterial AgentsPhase 29140
17Histamine AntagonistsPhase 2826
18Neurotransmitter AgentsPhase 214795
19Histamine H2 AntagonistsPhase 2132
20
histaminePhase 290675614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
21Ranitidine bismuth citratePhase 274
22Anti-Ulcer AgentsPhase 21453
23
BismuthPhase 21037440-69-916682734, 105143
Synonyms:
17034_FLUKA
24267-48-9
25243-76-9
264008_ALDRICH
265462_ALDRICH
265470_ALDRICH
452386_ALDRICH
556130_ALDRICH
7440-69-9
83Bi
95372_ALDRICH
95372_FLUKA
95375_FLUKA
AC1NSDYX
AC1O4PN8
AR-1I0647
BISMUTH, 99.95%
 
BISMUTH, 99.999%
Bi
Bismut
Bismuth standard for AAS
Bismuth standard for ICP
Bismuth(III) nitrate solution
Bismuth, elemental
Bismuth-209
C15471
CHEBI:33301
CID5359367
EINECS 231-177-4
HSDB 2078
LS-44708
LTBB002773
MolPort-003-925-759
Wismut
bismuth
bismuto
24Bismuth tripotassium dicitratePhase 255
25AntacidsPhase 21453
26Gastrointestinal AgentsPhase 26401
27CitrateNutraceuticalPhase 21001
28
Citric AcidnutraceuticalPhase 2100177-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
29
Omalizumabapproved, investigationalPhase 1137242138-07-4
Synonyms:
242138-07-4
D05251
Ig gamma-1 chain C region
Omalizumab
 
Omalizumab (USAN/INN)
Omalizumab (genetical recombination)
Omalizumab (genetical recombination) (JAN)
Xolair
Xolair (TN)
30Respiratory System AgentsPhase 13931
31ImmunoglobulinsPhase 14477
32AntibodiesPhase 14477
33Anti-Allergic AgentsPhase 11312
34Anti-Asthmatic AgentsPhase 12796
35Coagulase10
36Pulmonary Surfactants101
37Yellow DockNutraceutical5

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1Posaconazole to Treat Invasive Fungal InfectionsCompletedNCT00033982Phase 3
2Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency DiseasesRecruitingNCT01852370Phase 1, Phase 2
3CAMB/MAT2203 in Patients With Mucocutaneous CandidiasisRecruitingNCT02629419Phase 2
4Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) SyndromeTerminatedNCT00527878Phase 2
5Omalizumab to Treat Hyper-IgE (Job's) SyndromeCompletedNCT00260702Phase 1
6Diagnostic Effectiveness of Virtual BronchoscopyCompletedNCT00001515Phase 1
7Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related DisordersCompletedNCT00005933
8Role of Endotracheal Suction on the Occurrence of Meconium Aspiration Syndrome in Non-vigorous Meconium Stained BabiesCompletedNCT01758822
9Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent InfectionRecruitingNCT00006150
10Study of Mycobacterial InfectionsRecruitingNCT00018044
11Detection and Characterization of Infections and Infection SusceptibilityRecruitingNCT00404560
12Collection of Lung Fluid and Tissue Samples for ResearchRecruitingNCT00471250
13Human Immunity Against Staphylococcus Aureus Skin InfectionRecruitingNCT02262819
14Studies of Skin Microbes in Healthy People and in People With Skin ConditionsRecruitingNCT00605878
15Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in NeonatesRecruitingNCT02598648
16Genetic Analysis of Immune DisordersEnrolling by invitationNCT00001467
17NFIL3-induced Pathological Enhancement of IgE Class Switch Recombination in Hyper-IgE SyndromeNot yet recruitingNCT02228941

Search NIH Clinical Center for Hyper Ige Syndrome

Genetic Tests for Hyper Ige Syndrome

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Anatomical Context for Hyper Ige Syndrome

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MalaCards organs/tissues related to Hyper Ige Syndrome:

33
Skin, Lung, Bone, Bone marrow, Monocytes, Neutrophil, B cells

Animal Models for Hyper Ige Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hyper Ige Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9DOCK8, IL4, PGM3, STAT3, TYK2
2MP:00053877.6DOCK8, IL4, PGM3, STAT3, TYK2

Publications for Hyper Ige Syndrome

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Articles related to Hyper Ige Syndrome:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Causes of non-adherence to therapeutic guidelines in severe community-acquired pneumonia. (25909312)
2015
2
Atypical 581-kb 22q11.21 Deletion in a Patient with Oculo-Auriculo-Vertebral Spectrum Phenotype. (26919065)
2015
3
Reconstruction magnetic resonance neurography in chronic inflammatory demyelinating polyneuropathy. (25425460)
2015
4
Intrahepatic Cholestasis of Pregnancy: mRNAs for LIPF and ELOVL4 Genes Are Not Detectable in Circulating Maternal Plasma. (25059952)
2014
5
8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. (24489103)
2014
6
Impaired corneal biomechanical properties and the prevalence of keratoconus in mitral valve prolapse. (24864193)
2014
7
PGC-1I+ induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. (25009290)
2014
8
Individualizing clozapine and risperidone treatment for schizophrenia patients. (24329194)
2014
9
The World Report on Disability as a blueprint for international, national, and local aphasia services. (23101515)
2013
10
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. (22718491)
2013
11
Vaccination against meningitis B: is it worth it? (24432035)
2013
12
Low papillary structures in lepidic lung adenocarcinoma: any relationship with micropapillary lung adenocarcinoma? (24054172)
2013
13
Detection of immediate post-operative abdominal compartment after congenital diaphragmatic hernia closure. (23278938)
2013
14
Laparoscopic prophylactic total gastrectomy with linear stapler side-to-side esophagojejunal anastomosis for hereditary diffuse gastric cancer syndrome in 2 siblings. (23752020)
2013
15
Successful treatment of exercise-induced anaphylaxis with omalizumab. (23010237)
2012
16
Resistance to intravenous immunoglobulin (IVIG) in Kawasaki disease: no influence of different IVIG lot utilisation. (22410254)
2012
17
Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis. (22487288)
2012
18
Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions. (21937588)
2012
19
Hepatic portocholecystostomy (HPC) is ineffective in the treatment of biliary atresia with patent distal extrahepatic bile ducts. (21345004)
2011
20
NK cells prevalence, subsets and function in viral hepatitis C. (21972016)
2011
21
Hepcidin and iron-mediated resistance to malaria. (21882342)
2011
22
Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury. (20504881)
2010
23
Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis. (19967723)
2010
24
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells. (19944012)
2009
25
Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian origin. (19506858)
2009
26
Expression of HDGF and its implication in stage I non-small cell lung cancer]. (18478933)
2007
27
Novel membrane cell projection defects in Wiskott-Aldrich syndrome B cells. (17786274)
2007
28
Proximal origin and hypoplasia of the left pulmonary artery in association with chromosome 22q11 deletion, right aortic arch, and persistently patent right-sided arterial duct. (17868498)
2007
29
Failure of physiologic doses of pure UVA or UVB to induce lesions in photosensitive cutaneous lupus erythematosus: implications for phototesting. (17100736)
2006
30
Nongenomic actions of aldosterone: physiological or pathophysiological role? (16280143)
2006
31
A novel cryptic exon identified in the 3' region of intron 2 of the human dystrophin gene. (16133659)
2005
32
The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor. (15777837)
2005
33
Hemoglobin content is increased in the human erythroleukemia K562 cell line by a 56.2-kD peptide from uremic plasma. (15024177)
2004
34
Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells. (12483281)
2003
35
Intron 3 16 bp duplication polymorphism of p53 is associated with an increased risk for breast cancer by the age of 50 years. (11927843)
2002
36
Focal myositis in the mylohyoid muscle of an adult. (10709172)
2000
37
Mutation screening in Rett syndrome patients. (10745042)
2000
38
BERP, a novel ring finger protein, binds to alpha-actinin-4. (10673389)
2000
39
Mitomycin-C and vernal conjunctivitis: Author's reply (11097578)
2000
40
Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation. (10676812)
2000
41
Induction of reactive oxygen intermediates in human monocytes by tumour cells and their role in spontaneous monocyte cytotoxicity. (10070862)
1999
42
Eosinophilic cystitis following an infected urachal remnant. (10369914)
1999
43
The Chernobyl governmental program: two years of experience at the Belarusian Bone Marrow Transplant Centre. (9368316)
1997
44
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle. (7589458)
1995
45
Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. (8512620)
1993
46
Radiation-induced meningioma. (2011241)
1991
47
Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. (2460440)
1988
48
Pseudoepitheliomatous micaceous and keratotic balanitis. (3401420)
1988
49
50

Variations for Hyper Ige Syndrome

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Clinvar genetic disease variations for Hyper Ige Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PGM3NM_015599.2(PGM3): c.248T> C (p.Leu83Ser)single nucleotide variantPathogenicrs267608260GRCh37Chr 6, 83898474: 83898474
2PGM3NM_015599.2(PGM3): c.1504G> T (p.Asp502Tyr)single nucleotide variantPathogenicrs267608261GRCh37Chr 6, 83880059: 83880059
3PGM3NM_001199917.1(PGM3): c.1102_1104delGAA (p.Glu368del)deletionPathogenicrs267608259GRCh38Chr 6, 83178682: 83178684

Expression for genes affiliated with Hyper Ige Syndrome

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Search GEO for disease gene expression data for Hyper Ige Syndrome.

Pathways for genes affiliated with Hyper Ige Syndrome

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Pathways related to Hyper Ige Syndrome according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.5STAT3, TYK2
29.5STAT3, TYK2
39.5STAT3, TYK2
4
Show member pathways
9.5STAT3, TYK2
5
Show member pathways
9.5STAT3, TYK2
69.5STAT3, TYK2
79.5STAT3, TYK2
89.5STAT3, TYK2
99.5STAT3, TYK2
10
Show member pathways
9.5STAT3, TYK2
119.5STAT3, TYK2
129.5STAT3, TYK2
139.5STAT3, TYK2
149.3IL4, TYK2
159.0IGHE, IL4
16
Show member pathways
8.9IL4, STAT3, TYK2
17
Show member pathways
8.9IL4, STAT3, TYK2
18
Show member pathways
8.9IL4, STAT3, TYK2
19
Show member pathways
8.9IL4, STAT3, TYK2
20
Show member pathways
8.9IL4, STAT3, TYK2
21
Show member pathways
8.9IL4, STAT3, TYK2

GO Terms for genes affiliated with Hyper Ige Syndrome

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Biological processes related to Hyper Ige Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell activationGO:00508719.0IGHE, IL4

Sources for Hyper Ige Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet