HIES
MCID: HYP458
MIFTS: 65

Hyper Ige Syndrome (HIES) malady

Skin diseases, Blood diseases, Immune diseases categories

Summaries for Hyper Ige Syndrome

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21Genetics Home Reference, 42NIH Rare Diseases, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Hyper ige syndromes (hies) are rare primary immune deficiencies characterized by elevated serum ige, skin inflammation (dermatitis) and recurrent skin and lung infections. there are two forms of hies, which have the above characteristics in common but otherwise have distinct presentations, courses and outcomes: autosomal dominant hies (ad-hies) and autosomal recessive hies (ar-hies). individuals with ad-hies may also have varying degrees of connective tissue, skeletal, and dental abnormalities as well as a distinctive facial appearance. this form is inherited in an autosomal dominant manner and is caused by mutations in the stat3 gene in about 70% of cases. unique characteristics of ar-hies include extreme hypereosinophilia; susceptibility to viral infections such as herpes simplex and molluscum contagiosum; central nervous system involvement; t-cell defects; and a high death rate. ar-hies is inherited in an autosomal recessive manner and is often caused by mutations in the dock8 gene. last updated: 10/10/2012

MalaCards: Hyper Ige Syndrome, also known as job's syndrome, is related to dermatitis and atopic dermatitis, and has symptoms including hyperextensible joints/articular hyperlaxity, mutiple fractures/bone fragility and osteoporosis/osteopenia/demineralisation/osteomalacia/rickets. An important gene associated with Hyper Ige Syndrome is STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor)), and among its related pathways are TGF-Beta Pathway and Rheumatoid arthritis. The compounds cycloheximide and pdtc have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are renal/urinary system and skeleton.

Genetics Home Reference:21 Job syndrome is a condition that affects several body systems, particularly the immune system. Recurrent infections are common in people with this condition. Affected individuals tend to have frequent bouts of pneumonia, which are caused by certain kinds of bacteria that infect the lungs and cause inflammation. Recurrent skin infections and an inflammatory skin disorder called eczema are also very common in Job syndrome. These skin problems cause rashes, blisters, collections of pus (abscesses), open sores, and scaling.

Description from OMIM:46 147060

Aliases & Classifications for Hyper Ige Syndrome

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42NIH Rare Diseases, 21Genetics Home Reference, 60UMLS, 48Orphanet, 46OMIM, 44Novoseek, 10DISEASES, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
job syndrome:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

hyper ige syndrome 42
job's syndrome 42 21 60
job syndrome 42 21 48
hyperimmunoglobulin e-recurrent infection syndrome 21 48
hyper-ige recurrent infection syndrome 42 46
hyper-ige syndrome 21 44
buckley syndrome 21 48
hies 42 21
hyper-immunoglobulin e syndrome, autosomal dominant 60
autosomal dominant hyperimmunoglobulin e syndrome 48
autosomal dominant hyper-ige syndrome 48
hyperimmunoglobulin e syndrome type 1 48
hyperimmunoglobulin e syndrome 42
autosomal dominant hies 48
job-buckley syndrome 21
jobs syndrome 10
hie syndrome 21
ad-hies 48


External Ids:

OMIM46 147060
ICD10 via Orphanet26 D82.4
SNOMED-CT via Orphanet57 50926003

Related Diseases for Hyper Ige Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Hyper Ige Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 411)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.9IL17A, IL4, IGHE, IFNG, TLR9
2atopic dermatitis30.8IL4, RNASE3
3molluscum contagiosum30.5DOCK8
4pneumonia30.5TLR4, TLR3, CXCR2, IL17A, IL6, MMP8
5lupus erythematosus30.4TLR9
6systemic lupus erythematosus30.4TLR4, TLR9, IFNG, TYK2, IL4R, IL4
7dermatomyositis30.2IL17A
8diabetes mellitus30.2SELL, IL6
9myocardial infarction30.2SELL
10candidiasis30.2IFNG
11aspergillosis30.1TLR4, IFNG
12tetanus30.1IL4, IFNG
13asthma30.1IGHE, RNASE3, IL4
14food allergy30.1IGHE, RNASE3, IL4
15cutaneous t cell lymphoma30.1IFNG, STAT3, IL4, SELL
16burkitt's lymphoma30.1IL4, IL4R, CXCR1, CXCR2, TLR9
17psoriasis30.1IL4, IL17A, IL6, IL4R, CXCR1, TLR9
18obesity30.0STAT3, IL17A, IL6, SELL
19alzheimer's disease30.0IL6, CXCR2, TLR3
20breast cancer30.0TLR9, STAT3, CXCR1, IL4R, IL17A, MMP8
21tuberculosis30.0TLR4, TLR9, IFNG, CXCR2, CXCR1, IL4R
22acute myocardial infarction29.9MMP8
23thrombocytopenia29.8IL6, TLR4
24arthritis29.8SELL, IL6, IL17A
25influenza29.8IFNG, TLR3, TLR9
26allergic asthma29.8RNASE3, IL4R, IL4, IL17A, SELL, IGHE
27multiple sclerosis29.8IL4R, IL4, IL17A, IL6, MMP8, CXCR1
28pancreatitis29.6IL6
29infertility29.6IL17A
30cholera29.6IL17A
31eye disease29.6IL6
32diabetic retinopathy29.6SELL
33colorectal cancer29.6IL4R
34hepatitis29.6SELL, TLR3
35malaria29.6TLR9, IFNG
36keratitis29.6IL17A, TLR4
37encephalomyelitis29.6IFNG, STAT3, IL4, IL17A
38graft versus host disease29.6SELL, IL4, IFNG
39pulmonary tuberculosis29.6IFNG, CXCR1, IL4
40ovarian cancer29.6TLR3, STAT3, IL4R, IL17A
41graves' disease29.6IFNG, IL4R, IL4, SELL
42cystic fibrosis29.6IL17A, CXCR1, RNASE3, TLR4
43squamous cell carcinoma29.6STAT3, CXCR2, CXCR1, IL4R, SELL, TWIST1
44prostate cancer29.6TLR9, STAT3, TYK2, CXCR2, CXCR1, IL6
45ipex syndrome29.6TLR9, IFNG, IGHE, CXCR1, IL4R, IL4
46melanoma29.6TLR4, TLR9, IL4, IL4R, CXCR1, CXCR2
47hyperimmunoglobulin syndrome10.9
48autosomal dominant hyper ige syndrome10.8
49autosomal recessive hyper ige syndrome10.6
50job's syndrome10.5

Graphical network of the top 20 diseases related to Hyper Ige Syndrome:



Diseases related to hyper ige syndrome

Clinical Features for Hyper Ige Syndrome

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46OMIM, 48Orphanet
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Clinical features from OMIM:

147060

Clinical synopsis from OMIM:

147060

Symptoms:

48 (show all 38)
  • hyperextensible joints/articular hyperlaxity
  • mutiple fractures/bone fragility
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • cough
  • onyxis/paronyxis/ungual inflammation
  • dysplastic/thick/grooved fingernails
  • eosinophils anomalies/hypereosinophilia
  • craniostenosis/craniosynostosis/sutural synostosis
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • arterial aneurism (excluding aorta)
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • lymphoma
  • autosomal recessive inheritance
  • fever/chilling
  • hair and scalp anomalies
  • follicular/erythematous/edematous papules/milium
  • scoliosis
  • anomalies of the immunitary system
  • repeat respiratory infections
  • atelectasia/pulmonary collapse
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • pruritus/itching
  • eczema
  • cutaneous rash
  • chronic skin infection/ulcerations/ulcers/cancrum
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • autosomal dominant inheritance
  • frontal bossing/prominent forehead
  • chronic/relapsing otitis
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • anomalies of teeth and dentition
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • gingivitis
  • broad nose/nasal bridge
  • deepset eyes/enophthalmos
  • face/facial anomalies
  • anomalies of skin, subcutaneous tissue and mucosae

Drugs & Therapeutics for Hyper Ige Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyper Ige Syndrome

Drug clinical trials:

Search ClinicalTrials for Hyper Ige Syndrome

Search NIH Clinical Center for Hyper Ige Syndrome

Search CenterWatch for Hyper Ige Syndrome

Genetic Tests for Hyper Ige Syndrome

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Anatomical Context for Hyper Ige Syndrome

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32MalaCards
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MalaCards organs/tissues related to Hyper Ige Syndrome:

32
Skin, Lung, Bone, T cells, Eye

Animal Models for Hyper Ige Syndrome or affiliated genes

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36MGI
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Publications for Hyper Ige Syndrome

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Genetic Variations for Hyper Ige Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Hyper Ige Syndrome:

62 (show all 14)
id Symbol AA change Variation ID SNP ID
1STAT3p.Arg382LeuVAR_037365
2STAT3p.Arg382GlnVAR_037366
3STAT3p.Arg382TrpVAR_037367
4STAT3p.Phe384LeuVAR_037368
5STAT3p.Phe384SerVAR_037369
6STAT3p.Thr389IleVAR_037370
7STAT3p.Arg423GlnVAR_037371
8STAT3p.His437TyrVAR_037372
9STAT3p.Ser611AsnVAR_037375
10STAT3p.Phe621ValVAR_037376
11STAT3p.Thr622IleVAR_037377
12STAT3p.Val637LeuVAR_037378
13STAT3p.Val637MetVAR_037379
14STAT3p.Tyr657CysVAR_037381

Expression for genes affiliated with Hyper Ige Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyper Ige Syndrome

Search GEO for disease gene expression data for Hyper Ige Syndrome.

Pathways for genes affiliated with Hyper Ige Syndrome

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Sources:
51QIAGEN, 29KEGG, 52R&D Systems, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 59Tocris Bioscience
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Pathways related to Hyper Ige Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL4R
210.2TLR4
3
Hide members
10.1TYK2, IL4R
410.1IL4, IL4R
510.0TLR3, TLR9
610.0TYK2, IFNG, STAT3
710.0STAT3, TYK2, IL6
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.0IL6, STAT3, TYK2
910.0TLR9, TLR4
1010.0TLR9, TLR4
1110.0IL6, TYK2, IFNG
129.9IFNG, IL6, IL4
139.9IL6, IL4, IFNG
14
Hide members
9.9STAT3, TYK2, TLR4
159.9TYK2, IL4R, IL4
16
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
9.9IL17A, IL17C, STAT3
179.9IL4R, IL4, IFNG
189.9IL6, IL4R, IL4
199.9TLR9, IFNG, IL6
209.9IL4, IL6, TLR4
219.9IFNG, IL6, TLR4
22
Immune response Bacterial infections in normal airways
9.9IL6, IFNG, TLR4
23
Hide members
9.8STAT3, TYK2, IL4, IFNG
24
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.8IL4, STAT3, TYK2, IFNG
25
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9.8STAT3, IL6, TYK2, IFNG
269.8IL4, IGHE, IL4R
27
Hide members
9.8IL17A, IL4, IFNG, IL6
289.8TLR3, TLR4, TLR9
299.7IL6, TLR4, STAT3, TYK2
30
Cytokine production by Th17 cells in CF (Mouse model)
9.7TLR4, STAT3, IL17A, IL6
319.7STAT3, IL6, TLR4, IFNG
32
Development PDGF signaling via STATs and NF-kB
Hide members
9.7STAT3, IFNG, TYK2, IL17A, IL6
33
Hide members
9.6TLR4, IFNG, TLR3, IL6
34
Hide members
9.6TLR9, STAT3, TLR4, TLR3
359.6TLR4, IL6, TLR9, IL4
36
Hide members
9.6IL6, TLR9, TLR3, IL4R
37
Hide members
9.6IL6, TLR3, TLR9, TLR4
38
Hide members
9.6IL6, TLR4, TLR9, TLR3
39
Hide members
9.6STAT3, IL6, TYK2, IL4R, IL4
40
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9.5IFNG, RNASE3, IL6, IL4, IL4R
419.4IL4R, STAT3, IL4, TYK2, IFNG, IL6
429.3TLR4, IFNG, IL6, STAT3, TLR3, TLR9
43
Hide members
9.3IL6, STAT3, TLR3, TLR9, TLR4, IFNG
44
Hide members
9.1IL17A, IL4R, CXCR1, CXCR2, TYK2, TLR4
45
Hide members
9.1STAT3, TLR9, IL4, TLR4, IFNG, TLR3
46
Hide members
9.0IL4R, STAT3, TLR4, TLR9, IL4, IL6
47
Hide members
9.0TLR4, IFNG, STAT3, IL4R, IL4, IL17A
48
Hide members
9.0TLR9, IFNG, TLR4, IL6, STAT3, TYK2
49
Hide members
9.0IL4, TYK2, STAT3, IFNG, TLR3, TLR9
50
Hide members
8.9TYK2, IGHE, TLR9, IL6, STAT3, IFNG

Compounds for genes affiliated with Hyper Ige Syndrome

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Hyper Ige Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7SELL
2pdtc4410.4IL6, TLR4
3prednisolone44 28 1112.2IGHE, RNASE3, SELL
4resiquimod44 5911.1TLR3, TLR9, TLR4
5endotoxin4410.1RNASE3, SELL, CXCR2, TLR3
6polymyxin b4410.1IL4, IL6, TLR4, IFNG
7budesonide44 49 1112.0IL4, IFNG, IGHE, RNASE3
8fluticasone propionate44 49 59 1113.0IFNG, IGHE, RNASE3, IL4
9imiquimod44 28 59 1113.0TLR4, TLR3, IFNG, IL6
10fmlp4410.0CXCR2, RNASE3, SELL
11methacholine44 1111.0IGHE, RNASE3, IL4, IL17A
122,5-oligoadenylate449.9IFNG, TLR4, TLR3, IL6
13groalpha449.9CXCR1, IL17A, IL6, CXCR2
14nedocromil sodium449.9IL4, IGHE, RNASE3
15pentoxifylline44 1110.9IL4, IFNG, SELL, IL6
16ivig449.9IL4, IGHE, IFNG, IL6
17il 10449.9TLR4, IL6, IL4, IFNG, IL4R
18peptidoglycan44 2810.8TLR9, TLR3, IL6, TLR4
1915-deoxy-delta-12,14-prostaglandin j2449.8IFNG, IL6, STAT3, IL4
20simvastatin44 49 59 28 11 2414.8IFNG, TLR4, IL6, SELL, IL4
21tarc449.8CXCR1, IGHE, IFNG, IL4, IL4R
22ccl344 2810.8IL6, TLR9, IFNG, CXCR1, TLR4
23ionomycin449.8IL4R, IL4, SELL, IL17A, IFNG
24leukotriene b444 59 2411.8IL6, CXCR2, CXCR1, RNASE3, SELL
25infliximab44 49 1111.7IGHE, IL4, IFNG, TLR4, IL17A, IL6
26lipoteichoic acid449.7TLR9, IL6, TLR4, TLR3, CXCR2
27poly(i-c)449.7TLR3, IL4, TLR4, TLR9, IFNG, IL6
28ifn-alpha449.6TLR4, TLR3, IL6, IL17A, IFNG, TYK2
29herbimycin a44 5910.6IFNG, CXCR1, IL4, IL6, SELL, CXCR2
30sb 20358044 5910.6SELL, IL6, IL17A, IL4, STAT3, IFNG
31n acetylcysteine449.6IL6, STAT3, IGHE, TLR4, RNASE3, IL4
32allergens449.6IL4, IL4R, RNASE3, IGHE, IFNG, TLR4
33ly294002449.6IL17A, IL4, TYK2, STAT3, IL6, TLR3
34praziquantel44 1110.6IGHE, RNASE3, IL4
35polyinosinic-polycytidylic acid449.6TLR4, IL6, IL4, STAT3, IFNG, TLR3
36wortmannin449.4STAT3, CXCR1, CXCR2, TYK2, TLR3, TLR4
37histamine44 28 2411.3IL4R, TLR4, IGHE, SELL, IL6, IFNG
38lactate449.2TLR4, IGHE, IL6, MMP8, SELL, RNASE3
39genistein44 28 59 2 11 2414.2IL6, TLR4, CXCR1, STAT3, CXCR2, MMP8
40phosphatidylinositol449.1TLR4, TLR3, STAT3, TYK2, CXCR2, CXCR1
41actinomycin d449.1IL4, TLR4, IFNG, STAT3, IGHE, CXCR1
42alanine449.1MMP8, CXCR2, TLR4, STAT3, SELL, IGHE
43dexamethasone44 49 28 1112.1SELL, TLR4, TLR3, STAT3, IGHE, CXCR1
44rantes449.0IL4R, TLR4, STAT3, RNASE3, CXCR1, IL4
45oligonucleotide449.0RNASE3, MMP8, IL17A, CXCR1, STAT3, TLR3
46cyclosporin a44 28 5910.9MMP8, IL6, IL17A, STAT3, RNASE3, IL4
47nitric oxide44 11 2410.9IFNG, MMP8, IL6, IL17A, TLR3, RNASE3
48vegf448.5SELL, IFNG, TLR4, MMP8, IL6, IL17A
49retinoic acid44 249.4IL6, TLR4, TLR3, IFNG, STAT3, IGHE
50tyrosine448.1CXCR1, CXCR2, RNASE3, TYK2, STAT3, TLR3

GO Terms for genes affiliated with Hyper Ige Syndrome

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16Gene Ontology
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Cellular components related to Hyper Ige Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome membraneGO:03602010.0TLR3, TLR9
2external side of plasma membraneGO:0098979.3SELL, IL6, IL17A, IL4, IFNG, TLR4
3extracellular spaceGO:0056158.8IFNG, IL17C, IL4R, IL4, IL17A, IL6

Biological processes related to Hyper Ige Syndrome according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:00178110.5IL6, IFNG
2positive regulation of interleukin-23 productionGO:03274710.4IFNG, IL17A
3positive regulation of isotype switching to IgG isotypesGO:04830410.4IL4, IFNG
4fibroblast activationGO:07253710.4RGCC, IL17A
5positive regulation of interferon-alpha biosynthetic processGO:04535610.4TLR3, TLR9
6positive regulation of toll-like receptor signaling pathwayGO:03412310.3TLR9, TLR3
7positive regulation of chemokine biosynthetic processGO:04508010.3IL4, IFNG, TLR3
8positive regulation of T-helper 2 cell differentiationGO:04563010.3IL6, IL4R
9interleukin-8-mediated signaling pathwayGO:03811210.3CXCR1, CXCR2
10interleukin-6-mediated signaling pathwayGO:07010210.3STAT3, IL6
11positive regulation of MHC class II biosynthetic processGO:04534810.3TLR4, IFNG, IL4
12positive regulation of cytokine production involved in inflammatory responseGO:190001710.3IL17C, IL17A
13positive regulation of T cell proliferationGO:04210210.3IFNG, IL4, IL6
14positive regulation of interleukin-12 biosynthetic processGO:04508410.2TLR4, IFNG
15negative regulation of osteoclast differentiationGO:04567110.2TLR4, TLR3, IL4
16positive regulation of interleukin-10 productionGO:03273310.2IL4, TLR9, TLR4
17positive regulation of nitric oxide biosynthetic processGO:04542910.2TLR4, IFNG, IL6
18regulation of cytokine secretionGO:05070710.2TLR4, TLR9
19positive regulation of interferon-beta biosynthetic processGO:04535910.2TLR4, TLR9, TLR3
20I-kappaB phosphorylationGO:00725210.2TLR4, TLR9, TLR3
21positive regulation of NF-kappaB import into nucleusGO:04234610.2TLR4, TLR9, TLR3
22positive regulation of interleukin-8 productionGO:03275710.2TLR3, TLR9, TLR4
23positive regulation of interferon-beta productionGO:03272810.2TLR4, TLR9, TLR3
24negative regulation of interleukin-17 productionGO:03270010.2TLR4, IFNG
25defense response to protozoanGO:04283210.1IFNG, IL4R, IL4, IL6
26positive regulation of inflammatory responseGO:05072910.1TLR3, TLR9, TLR4
27positive regulation of JNK cascadeGO:04633010.1TLR3, TLR9, TLR4
28positive regulation of interleukin-12 productionGO:03273510.0IFNG, TLR3, TLR9, TLR4
29positive regulation of chemokine productionGO:03272210.0TLR4, TLR9, TLR3, IL6
30positive regulation of interleukin-6 productionGO:03275510.0IL6, TLR3, TLR9, TLR4
31cytokine-mediated signaling pathwayGO:01922110.0IL6, TYK2, STAT3, IFNG
32positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.0TLR9, TLR4
33negative regulation of cytokine secretionGO:05071010.0RGCC, IL6
34positive regulation of NF-kappaB transcription factor activityGO:05109210.0IL6, TLR3, TLR9, TLR4
35positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.9RGCC, IL6, IL4
36defense response to bacteriumGO:0427429.8TLR4, TLR9, TLR3, IFNG, RNASE3
37positive regulation of tumor necrosis factor productionGO:0327609.8TWIST1, IFNG, TLR3, TLR9, TLR4
38cell surface receptor signaling pathwayGO:0071669.8IL17C, CXCR1, CXCR2, IFNG
39positive regulation of interferon-gamma biosynthetic processGO:0450789.7TLR3, TLR9
40immune responseGO:0069559.7TLR4, IGHE, IL4R, IL4, IL17A
41response to drugGO:0424939.7IFNG, STAT3, IL4, IL6
42inflammatory responseGO:0069549.3TLR9, TLR3, CXCR2, CXCR1, IL17C, IL17A
43positive regulation of transcription from RNA polymerase II promoterGO:0459449.2TLR4, TLR9, TLR3, IFNG, STAT3, IL4

Molecular functions related to Hyper Ige Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-8 bindingGO:0199599.9CXCR1, CXCR2
2interleukin-8 receptor activityGO:0049189.6CXCR1, CXCR2
3cytokine activityGO:0051259.4IL6, IL17A, IL4, IL17C, IFNG

Products for genes affiliated with Hyper Ige Syndrome

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  • Antibodies
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Sources for Hyper Ige Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet