Aliases & Classifications for Hyper Ige Syndrome

MalaCards integrated aliases for Hyper Ige Syndrome:

Name: Hyper Ige Syndrome 50
Hyper-Ige Syndrome 29 52
Hyper-Ige Recurrent Infection Syndrome 50
Hyperimmunoglobulin E Syndrome 50
Job Syndrome 69
Hies 50

Classifications:



Summaries for Hyper Ige Syndrome

NIH Rare Diseases : 50 hyper ige syndromes (hies) are rare primary immune deficiencies characterized by elevated serum ige, skin inflammation (dermatitis) and recurrent skin and lung infections. there are two forms of hies, which have the above characteristics in common but otherwise have distinct presentations, courses and outcomes: autosomal dominant hies (ad-hies) and autosomal recessive hies (ar-hies). click on the embedded links to learn more about autosomal dominant hies (or job syndrome) and autosomal recessive hies. last updated: 7/14/2015

MalaCards based summary : Hyper Ige Syndrome, also known as hyper-ige syndrome, is related to asthma and his bundle tachycardia. An important gene associated with Hyper Ige Syndrome is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Miconazole and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Hyper Ige Syndrome

Diseases related to Hyper Ige Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
id Related Disease Score Top Affiliating Genes
1 asthma 28.6 IFNG IGHE IL4 IL4R
2 his bundle tachycardia 12.1
3 hyper-ige recurrent infection syndrome 11.9
4 hyper-ige recurrent infection syndrome, autosomal recessive 11.9
5 immunodeficiency 35 11.1
6 leukocyte adhesion deficiency, type iii 11.0
7 bursitis 10.5 STAT3 TYK2
8 sternal cleft 10.5 IFNG IGHE
9 papillary squamous carcinoma 10.4 IFNG IGHE
10 epidermolysis bullosa acquisita 10.3 IFNG STAT3
11 orbit alveolar rhabdomyosarcoma 10.3 IGHE IL4
12 hypoparathyroidism, x-linked 10.3 IGHE IL4
13 apple allergy 10.3 IGHE IL4
14 purpura fulminans 10.3 IGHE IL4
15 myoclonic astatic epilepsy 10.3 IFNG IL4
16 cow milk allergy 10.2 IL4 IL4R
17 retinal cancer 10.2 DOCK8 IFNG STAT3
18 eye accommodation disease 10.2 IFNG IL4
19 thelaziasis 10.2 IFNG IL4
20 centronuclear myopathy 5 10.2 IFNG IL4
21 oropharyngeal cancer, childhood 10.2 IFNG IL4
22 periarthritis 10.2 DOCK8 STAT3 TYK2
23 dermatitis 10.2
24 autoimmune disease, multisystem, infantile-onset, 1 10.2 DOCK8 STAT3 TYK2
25 lymphocytic colitis 10.2 IFNG IL4
26 acute gonococcal prostatitis 10.2 IFNG IL4
27 fibrous histiocytoma 10.1 IFNG IL4
28 lymphoma 10.1
29 spindle cell hemangioma 10.1 IFNG IL4
30 tularemia 10.1 IFNG IL4
31 gonadal disease 10.1 IFNG IL4
32 childhood brain stem glioma 10.1 IFNG IL4
33 atopic dermatitis 10.1
34 early-onset zonular cataract 10.1 IFNG IL4
35 acute vascular insufficiency of intestine 10.1 IFNG IL4
36 diffuse glomerulonephritis 10.1 IFNG IL4
37 dieulafoy lesion 10.0 IFNG IL4
38 acute monoblastic leukemia 10.0 IFNG IL4
39 bulbospinal polio 10.0 IFNG TLR4
40 reardon wilson cavanagh syndrome 10.0 IFNG IL4
41 ethmoid sinus cancer 10.0 IFNG TLR4
42 hematopoietic stem cell transplantation 10.0
43 hereditary choroidal atrophy 10.0 IFNG TLR4
44 loiasis 10.0 IFNG IL4
45 eczematous dermatitis of eyelid 9.9 IFNG STAT3 TYK2
46 vulvar nodular hidradenoma 9.9 IFNG IL4 STAT3
47 pneumonia 9.9
48 molluscum contagiosum 9.9
49 aneurysm 9.9
50 brain injury 9.9 STAT3 TLR4

Graphical network of the top 20 diseases related to Hyper Ige Syndrome:



Diseases related to Hyper Ige Syndrome

Symptoms & Phenotypes for Hyper Ige Syndrome

MGI Mouse Phenotypes related to Hyper Ige Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 DOCK8 IFNG IL4 IL4R PGM3 STAT3
2 immune system MP:0005387 9.86 TYK2 DOCK8 IFNG IL4 IL4R PGM3
3 digestive/alimentary MP:0005381 9.85 IFNG IL4 IL4R PGM3 STAT3 TLR4
4 liver/biliary system MP:0005370 9.55 IFNG IL4 IL4R STAT3 TLR4
5 renal/urinary system MP:0005367 9.35 IFNG IL4 PGM3 STAT3 TLR4
6 respiratory system MP:0005388 9.02 IFNG IL4 IL4R STAT3 TLR4

Drugs & Therapeutics for Hyper Ige Syndrome

Drugs for Hyper Ige Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
2
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
3 Antifungal Agents Phase 3,Phase 2
4 Anti-Infective Agents Phase 3,Phase 2
5 Antiparasitic Agents Phase 3,Phase 2
6 Antiprotozoal Agents Phase 3,Phase 2
7 Cytochrome P-450 Enzyme Inhibitors Phase 3
8 Hormone Antagonists Phase 3
9 Hormones Phase 3
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
11 Steroid Synthesis Inhibitors Phase 3
12
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
13
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
14
Ranitidine Approved Phase 2 66357-59-3, 66357-35-5 3001055
15 Antibodies Phase 2,Phase 1
16 Immunoglobulins Phase 2,Phase 1
17 Anti-Bacterial Agents Phase 2
18 Autoantibodies Phase 2
19 Liposomal amphotericin B Phase 2
20 Agglutinins Phase 2
21 Vaccines Phase 2
22 Antacids Phase 2
23 Anti-Ulcer Agents Phase 2
24
Bismuth Phase 2 7440-69-9 16682734 105143
25 Bismuth tripotassium dicitrate Phase 2
26 Gastrointestinal Agents Phase 2
27 Histamine Antagonists Phase 2
28 Histamine H2 Antagonists Phase 2
29
Histamine Phosphate Phase 2 51-74-1 65513
30 Neurotransmitter Agents Phase 2
31 Ranitidine bismuth citrate Phase 2
32 Citrate Nutraceutical Phase 2
33
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311
34
Omalizumab Approved, Investigational Phase 1 242138-07-4
35 Anti-Allergic Agents Phase 1
36 Anti-Asthmatic Agents Phase 1
37 Respiratory System Agents Phase 1
38 Coagulase
39 Pulmonary Surfactants
40 Yellow Dock Nutraceutical

Interventional clinical trials:

(show all 18)

id Name Status NCT ID Phase Drugs
1 Posaconazole to Treat Invasive Fungal Infections Completed NCT00033982 Phase 3 Posaconazole
2 CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis Recruiting NCT02629419 Phase 2 Amphotericin B
3 Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases Recruiting NCT01852370 Phase 1, Phase 2
4 Safety, Tolerability, and Immunogenicity of One Dose of NDV 3A Vaccine in People With STAT3-Mutated Hyper-IgE Syndrome Suspended NCT02996448 Phase 2 NDV-3A
5 Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) Syndrome Terminated NCT00527878 Phase 2 Ranitidine;Placebo
6 Omalizumab to Treat Hyper-IgE (Job's) Syndrome Completed NCT00260702 Phase 1 Omalizumab (Xolair)
7 Diagnostic Effectiveness of Virtual Bronchoscopy Completed NCT00001515 Phase 1
8 NFIL3-induced Pathological Enhancement of IgE Class Switch Recombination in Hyper-IgE Syndrome Unknown status NCT02228941
9 Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders Completed NCT00005933
10 Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection Recruiting NCT00006150
11 Study of Mycobacterial Infections Recruiting NCT00018044
12 Human Immunity Against Staphylococcus Aureus Skin Infection Recruiting NCT02262819
13 Collection of Lung Fluid and Tissue Samples for Research Recruiting NCT00471250
14 Studies of Skin Microbes in Healthy People and in People With Skin Conditions Recruiting NCT00605878
15 Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations Recruiting NCT03278912
16 Detection and Characterization of Infections and Infection Susceptibility Recruiting NCT00404560
17 Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates Recruiting NCT02598648
18 Genetic Analysis of Immune Disorders Enrolling by invitation NCT00001467

Search NIH Clinical Center for Hyper Ige Syndrome

Genetic Tests for Hyper Ige Syndrome

Genetic tests related to Hyper Ige Syndrome:

id Genetic test Affiliating Genes
1 Hyper-Ige Syndrome 29

Anatomical Context for Hyper Ige Syndrome

MalaCards organs/tissues related to Hyper Ige Syndrome:

39
Skin, Lung, T Cells, Bone, Bone Marrow, B Cells, Neutrophil

Publications for Hyper Ige Syndrome

Articles related to Hyper Ige Syndrome:

(show top 50) (show all 253)
id Title Authors Year
1
Molecular Typing of Staphylococcus aureus Isolated from Patients with Autosomal Dominant Hyper IgE Syndrome. ( 28587312 )
2017
2
Novel Mutation in SH2 Domain of STAT3 (p.M660T) in Hyper-IgE Syndrome with Sterno-Clavicular and Paravertebral Abscesses. ( 28315006 )
2017
3
Progressive multifocal leukoencephalopathy in a patient with lymphoma and presumptive hyper IgE syndrome. ( 28643229 )
2017
4
Gastrointestinal Manifestations of STAT3-Deficient Hyper-IgE Syndrome. ( 28803389 )
2017
5
Squamous Cell Carcinoma With Hyper-IgE Syndrome: A Case Report. ( 28902078 )
2017
6
Hyper IgE Syndrome and Renal Cell Carcinoma. ( 28607797 )
2017
7
Pediatric anaphylaxis and hyper IgE syndrome. ( 28280372 )
2017
8
Acute cardiac disease in a patient with hyper-IgE syndrome. ( 28884991 )
2017
9
Clinical Manifestations and Genetic Analysis of 17 Patients with Autosomal Dominant Hyper-IgE Syndrome in Mainland China: New Reports and a Literature Review. ( 28197791 )
2017
10
AD Hyper-IgE Syndrome Due to a Novel Loss-of-Function Mutation in STAT3: a Diagnostic Pursuit Won by Clinical Acuity. ( 27844301 )
2017
11
Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin Positive S. aureus Mimic Hyper IgE Syndrome in an Infant. ( 28938255 )
2017
12
Life-Threatening Pneumopathy and U urealyticum in a STAT3-Deficient Hyper-IgE Syndrome Patient. ( 28562253 )
2017
13
Cold-induced hyperhidrosis: possible association with hyper-IgE syndrome. ( 27778332 )
2017
14
Coronary atherosclerosis and dilation in hyper IgE syndrome patients: Depiction by magnetic resonance vessel wall imaging and pathological correlation. ( 28167354 )
2017
15
Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome. ( 28203787 )
2017
16
Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. ( 28939137 )
2017
17
Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. ( 27799162 )
2016
18
Hyper-IgE syndrome with a novel mutation of the STAT3 gene. ( 27333819 )
2016
19
Key findings to expedite the diagnosis of hyper-IgE syndromes in infants and young children. ( 26592211 )
2016
20
TH17 Cells in STAT3 Related Hyper-IgE Syndrome. ( 27226025 )
2016
21
Autosomal Dominant Hyper IgE Syndrome - Treatment Strategies and Clinical Outcomes. ( 26743515 )
2016
22
Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome. ( 27315770 )
2016
23
Th2 and Th9 responses in patients with chronic mucocutaneous candidiasis and hyper-IgE syndrome. ( 27474157 )
2016
24
The Potential and Limits of Hematopoietic Stem Cell Transplantation for the Treatment of Autosomal Dominant Hyper-IgE Syndrome. ( 27091139 )
2016
25
B-cell-specific STAT3 deficiency: Insight into the molecular basis ofA autosomal-dominant hyper-IgE syndrome. ( 27423495 )
2016
26
Novel DOCK8 gene mutations lead to absence of protein expression in patients with hyper-IgE syndrome. ( 26659092 )
2016
27
Hyper-IgE Syndrome in an Infant. ( 26801049 )
2016
28
Liver abscess in a boy with hyper IgE syndrome. ( 27843873 )
2016
29
Somatic mosaicism in B cells of a patient with autosomal dominant hyper IgE syndrome. ( 27488252 )
2016
30
Investigation of Skin Barrier Functions and Allergic Sensitization in Patients with Hyper-IgE Syndrome. ( 26453584 )
2015
31
Caring for children with hyper-IgE syndrome. ( 26166283 )
2015
32
PID in Disguise: Molecular Diagnosis of IRAK-4 Deficiency in an Adult Previously Misdiagnosed With Autosomal Dominant Hyper IgE Syndrome. ( 26472314 )
2015
33
Brain Abscess and Keratoacanthoma Suggestive of Hyper IgE Syndrome. ( 26060590 )
2015
34
Quantitative defects in invariant NKT cells and TLR responses in patients with hyper-IgE syndrome. ( 25796310 )
2015
35
Giant Herpes Labialis in a Child with DOCK8-deficient Hyper-IgE Syndrome. ( 26148752 )
2015
36
Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort. ( 26293184 )
2015
37
Successful haploidentical donor hematopoietic stem cell transplant and restoration of STAT3 function in an adolescent with autosomal dominant hyper-IgE syndrome. ( 25962528 )
2015
38
Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation. ( 26687240 )
2015
39
An 8 minute colorimetric paper-based reverse phase vertical flow serum microarray for screening of hyper IgE syndrome. ( 26365343 )
2015
40
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome. ( 26304966 )
2015
41
Cerebral aneurysm in a 12-year-old boy with a STAT3 mutation (hyper-IgE syndrome). ( 25814298 )
2015
42
Whole Genome Sequencing Reveals a Chromosome 9p Deletion Causing DOCK8 Deficiency in an Adult Diagnosed with Hyper IgE Syndrome Who Developed Progressive Multifocal Leukoencephalopathy. ( 25388448 )
2014
43
Hyper IgE syndrome. ( 24616862 )
2014
44
Hyper IgE syndrome: anaphylaxis in a patient carrying the N567D STAT3 mutation. ( 24628715 )
2014
45
Novel STAT3 mutation causing hyper-IgE syndrome: studies of the clinical course and immunopathology. ( 24627079 )
2014
46
A novel case of Hyper IgE syndrome combined with natural killer cell deficiency. ( 24571902 )
2014
47
Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India. ( 25543043 )
2014
48
Recurrent Skin and Lung Infections in Autosomal Dominant Hyper IgE Syndrome with Transactivation Domain STAT3 Mutation. ( 25379309 )
2014
49
Bone Density and Fractures in Autosomal Dominant Hyper IgE Syndrome. ( 24402620 )
2014
50
A case of exuberant candidal onychomycosis in a child with hyper IgE syndrome. ( 24565777 )
2014

Variations for Hyper Ige Syndrome

ClinVar genetic disease variations for Hyper Ige Syndrome:

6 (show all 11)
id Gene Variation Type Significance SNP ID Assembly Location
1 STAT3 NM_139276.2(STAT3): c.1387_1389delGTG (p.Val463del) deletion Pathogenic rs113994138 GRCh37 Chromosome 17, 40477056: 40477058
2 STAT3 NM_139276.2(STAT3): c.1144C> T (p.Arg382Trp) single nucleotide variant Pathogenic rs113994135 GRCh37 Chromosome 17, 40481661: 40481661
3 STAT3 NM_139276.2(STAT3): c.1145G> A (p.Arg382Gln) single nucleotide variant Pathogenic rs113994136 GRCh37 Chromosome 17, 40481660: 40481660
4 STAT3 NM_139276.2(STAT3): c.1268G> A (p.Arg423Gln) single nucleotide variant Pathogenic rs113994137 GRCh37 Chromosome 17, 40481441: 40481441
5 STAT3 STAT3, ARG383LEU single nucleotide variant Pathogenic
6 STAT3 NM_139276.2(STAT3): c.1909G> A (p.Val637Met) single nucleotide variant Pathogenic rs113994139 GRCh37 Chromosome 17, 40474492: 40474492
7 STAT3 NM_139276.2(STAT3): c.1243G> A (p.Glu415Lys) single nucleotide variant Pathogenic/Likely pathogenic rs193922717 GRCh37 Chromosome 17, 40481466: 40481466
8 STAT3 NM_139276.2(STAT3): c.1166C> T (p.Thr389Ile) single nucleotide variant Pathogenic rs397514766 GRCh37 Chromosome 17, 40481639: 40481639
9 PGM3 NM_015599.2(PGM3): c.248T> C (p.Leu83Ser) single nucleotide variant Pathogenic rs267608260 GRCh37 Chromosome 6, 83898474: 83898474
10 PGM3 NM_015599.2(PGM3): c.1504G> T (p.Asp502Tyr) single nucleotide variant Pathogenic rs267608261 GRCh37 Chromosome 6, 83880059: 83880059
11 PGM3 NM_001199917.1(PGM3): c.1102_1104delGAA (p.Glu368del) deletion Pathogenic rs267608259 GRCh38 Chromosome 6, 83178682: 83178684

Expression for Hyper Ige Syndrome

Search GEO for disease gene expression data for Hyper Ige Syndrome.

Pathways for Hyper Ige Syndrome

Pathways related to Hyper Ige Syndrome according to GeneCards Suite gene sharing:

(show all 46)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 IFNG IGHE IL4 IL4R STAT3 TLR4
2
Show member pathways
13.45 IFNG IL4 IL4R STAT3 TLR4 TYK2
3
Show member pathways
13.15 IFNG IGHE IL4 IL4R STAT3 TYK2
4
Show member pathways
13.02 IFNG IL4 IL4R STAT3 TLR4
5
Show member pathways
12.87 IL4 IL4R STAT3 TYK2
6
Show member pathways
12.61 IL4 IL4R STAT3 TYK2
7
Show member pathways
12.61 IFNG IL4 STAT3 TLR4 TYK2
8 12.51 IL4 IL4R TLR4 TYK2
9
Show member pathways
12.46 IFNG IGHE IL4 IL4R
10 12.37 IFNG IL4 STAT3 TYK2
11
Show member pathways
12.19 STAT3 TLR4 TYK2
12
Show member pathways
12.18 IFNG IL4 STAT3
13
Show member pathways
12.17 IFNG IL4 IL4R STAT3 TLR4 TYK2
14
Show member pathways
12.16 IFNG STAT3 TYK2
15
Show member pathways
12.15 IGHE IL4 IL4R STAT3 TYK2
16 12.14 IFNG STAT3 TYK2
17
Show member pathways
12.04 IFNG IL4 TLR4
18 12.04 IFNG STAT3 TLR4
19
Show member pathways
12 IFNG IL4 TYK2
20
Show member pathways
11.99 IFNG IL4 STAT3 TLR4 TYK2
21
Show member pathways
11.89 IFNG IL4 IL4R STAT3 TYK2
22 11.86 IFNG IL4 TLR4
23
Show member pathways
11.79 IFNG IL4 STAT3 TYK2
24 11.76 IFNG STAT3 TLR4
25
Show member pathways
11.73 IFNG STAT3 TLR4 TYK2
26 11.72 IFNG IL4R STAT3 TYK2
27
Show member pathways
11.7 IFNG STAT3
28 11.53 IGHE IL4 IL4R
29 11.41 IL4 STAT3 TYK2
30 11.41 IGHE IL4 IL4R STAT3 TYK2
31 11.38 IFNG TLR4
32 11.38 IFNG IL4 IL4R
33 11.34 STAT3 TYK2
34 11.3 STAT3 TYK2
35
Show member pathways
11.28 STAT3 TYK2
36 11.23 STAT3 TLR4 TYK2
37 11.19 IFNG IL4 IL4R
38 11.18 IFNG IL4
39 11.14 IFNG IL4
40
Show member pathways
11.11 IFNG IL4 IL4R STAT3 TLR4 TYK2
41 11.1 IFNG STAT3
42
Show member pathways
11.1 IFNG STAT3 TYK2
43 11.07 IFNG IL4
44 10.94 IL4 IL4R
45 10.91 STAT3 TYK2
46 10.77 IL4 IL4R

GO Terms for Hyper Ige Syndrome

Cellular components related to Hyper Ige Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IFNG IGHE IL4 TLR4

Biological processes related to Hyper Ige Syndrome according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.75 IFNG IGHE TLR4
2 positive regulation of nitric oxide biosynthetic process GO:0045429 9.59 IFNG TLR4
3 positive regulation of B cell proliferation GO:0030890 9.58 IL4 TLR4
4 positive regulation of interleukin-12 production GO:0032735 9.56 IFNG TLR4
5 positive regulation of interleukin-10 production GO:0032733 9.55 IL4 TLR4
6 immune response GO:0006955 9.55 IFNG IGHE IL4 IL4R TLR4
7 negative regulation of osteoclast differentiation GO:0045671 9.54 IL4 TLR4
8 positive regulation of myoblast fusion GO:1901741 9.52 IL4 IL4R
9 positive regulation of mast cell degranulation GO:0043306 9.48 IL4 IL4R
10 negative regulation of interleukin-17 production GO:0032700 9.46 IFNG TLR4
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IFNG IL4
12 positive regulation of chemokine biosynthetic process GO:0045080 9.4 IFNG IL4
13 positive regulation of immunoglobulin production GO:0002639 9.37 IL4 IL4R
14 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.32 IFNG TLR4
15 positive regulation of interleukin-1 beta secretion GO:0050718 9.27 IFNG
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 IFNG IL4
17 positive regulation of macrophage activation GO:0043032 9.21 IL4R
18 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.19 IL4
19 defense response to protozoan GO:0042832 9.13 IFNG IL4 IL4R
20 positive regulation of MHC class II biosynthetic process GO:0045348 8.8 IFNG IL4 TLR4

Sources for Hyper Ige Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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