MCID: HYP065
MIFTS: 59

Hyperaldosteronism malady

Endocrine diseases category

Summaries for Hyperaldosteronism

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards: Hyperaldosteronism is related to hypertension and adenoma. An important gene associated with Hyperaldosteronism is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Insulin Processing and Glucuronidation. The drugs spironolactone and spironolactone pwdr and the compounds 18-hydroxycorticosterone and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia:63 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

Aliases & Classifications for Hyperaldosteronism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hyperaldosteronism 8 10 44 60


External Ids:

Disease Ontology8 DOID:446
ICD9CM27 255.10, 255.1
MeSH34 D006929
ICD1025 E26, E26.0, E26.9

Related Diseases for Hyperaldosteronism

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Familial Hyperaldosteronism Type 2 family:

hyperaldosteronism Hyperaldosteronism, Familial, Type Iii
Familial Hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1NPPA, AGTR1, POMC, CYP11B2, CYP17A1, TH
2adenoma30.9CYP11B1, NR3C2, MEN1, POMC, KCNJ5, PMS2
3adrenal adenoma30.7POMC, CYP11B1, CYP17A1, CYP21A2, REN, AGTR1
4conn's syndrome30.6NPPA, NR3C2, AGTR1, REN, POMC, CYP11B1
5essential hypertension30.6NPPA, NR3C2, AGTR1, CYP11B1, CYP11B2, REN
6hypokalemia30.5CYP17A1, REN, CLCNKB, SLC12A3, ACE, CYP11B2
7adrenal carcinoma30.5POMC
8glucocorticoid-remediable aldosteronism30.5NR3C2, CYP11B1, REN, CYP11B2, POMC
9hyperparathyroidism30.4MEN1
10pheochromocytoma30.3MEN1, POMC, NPPA, TH
11adrenocortical carcinoma30.3CYP11B1, AGTR1, POMC, CYP21A2, CYP17A1, CYP11B2
12apparent mineralocorticoid excess syndrome30.0NR3C2
13bartter syndrome type 330.0SLC12A3, CLCNKB, REN
14cushing's syndrome30.0POMC, NR3C2
15hypothyroidism29.8POMC
16vitiligo29.8POMC
17malignant hypertension29.8REN, ACE
18renal hypertension29.8ACE, REN
19nephrosclerosis29.8ACE, NR3C2, AGTR1
20pseudohypoaldosteronism29.8NR3C2, SLC12A3, REN, CYP21A2
21congestive heart failure29.8NPPA, REN, CYP11B2, ACE, AGTR1, NR3C2
22diabetes mellitus29.7ACE, AGTR1, NR3C2, NPPA, KCNJ5, POMC
23familial hyperaldosteronism type 210.4
24familial hyperaldosteronism10.4
25hyperaldosteronism, familial, type iii10.3
26primary hyperparathyroidism10.2
27bartter syndrome, type 210.2
28kidney disease10.1
29myopathy10.1
30cystic fibrosis10.0
31hyperprolactinemia10.0
32polyarteritis nodosa10.0
33polycystic kidney disease10.0
34autosomal dominant disease10.0
35peritonitis10.0
36renal adenoma10.0
37polycystic kidney disease, autosomal dominant10.0
38hypocalcemia, autosomal dominant10.0
39bartter syndrome type 4a10.0
40diabetes insipidus10.0POMC
41fibromuscular dysplasia10.0REN
42mitral valve prolapse10.0AGTR1
43uremia10.0MEN1
44mitral valve disease10.0NPPA
45anuria10.0ACE
46lung cancer10.0POMC
47panic disorder10.0POMC
48hypoglycemia10.0KCNJ5, POMC
49thyroiditis10.0POMC
50glomerulonephritis10.0AGTR1

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to hyperaldosteronism

Clinical Features for Hyperaldosteronism

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Drugs & Therapeutics for Hyperaldosteronism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperaldosteronism

Drug clinical trials:

Search ClinicalTrials for Hyperaldosteronism

Search NIH Clinical Center for Hyperaldosteronism

Search CenterWatch for Hyperaldosteronism

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperaldosteronism

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Anatomical Context for Hyperaldosteronism

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32MalaCards
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MalaCards organs/tissues related to Hyperaldosteronism:

32
Adrenal gland, Testes, Kidney, Pituitary, Heart, Adrenal cortex, Cortex, Endothelial, Colon, Liver, Hypothalamus, Skin

Animal Models for Hyperaldosteronism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperaldosteronism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7PMS2, MEN1, CYP11B1, CYP11B2
2MP:00053979.3GNA12, NPPA, NR3C2, POMC, CYP11B1, REN
3MP:00053679.3NPPA, NR3C2, AGTR1, POMC, CYP11B1, CYP11B2
4MP:00107688.8PMS2, GNA12, MEN1, NR3C2, AGTR1, POMC
5MP:00053858.8ACE, KCNJ5, GNA12, NPPA, MEN1, NR3C2
6MP:00053768.4AGTR1, NR3C2, MEN1, NPPA, GNA12, PMS2

Publications for Hyperaldosteronism

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50PubMed
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Articles related to Hyperaldosteronism:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Hypertension caused by primary hyperaldosteronism: increased heart damage and cardiovascular risk. (23153688)
2013
2
Adrenal myelolipoma associated with primary hyperaldosteronism. (22294014)
2012
3
A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. (22628607)
2012
4
Adrenal venous sampling as a diagnostic procedure for primary hyperaldosteronism: experience from a tertiary referral centre. (22801561)
2012
5
The clinical utility of two renin mass methods to detect primary hyperaldosteronism compared with renin activity. (21427267)
2011
6
Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma. (21801737)
2011
7
Diagnosis and surgical management for primary hyperaldosteronism. (20425638)
2010
8
Familial hyperaldosteronism I-III. (20131203)
2010
9
Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma. (19180717)
2008
10
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. (18307725)
2008
11
Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin. (17991729)
2008
12
Primary hyperaldosteronism in a patient with end-stage renal disease. (17127694)
2007
13
Adrenal venous sampling in primary hyperaldosteronism: comparison of radiographic with biochemical success and the clinical decision-making with "less than ideal" testing. (17188130)
2006
14
Primary hyperaldosteronism in a dog with concurrent lymphoma. (17054483)
2006
15
Primary hyperaldosteronism, a mediator of progressive renal disease in cats. (15620809)
2005
16
Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity. (16003173)
2005
17
Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). (15241622)
2004
18
Retention of heterozygosity at chromosome 7p22 and 11q13 in aldosterone-producing tumours of patients with familial hyperaldosteronism not remediable by glucocorticoids. (15175634)
2004
19
How to diagnose and treat a licorice-induced syndrome with findings similar to that of primary hyperaldosteronism. (14964572)
2004
20
Primary hyperaldosteronism. (14503982)
2003
21
Hyperaldosteronism and pheochromocytoma: new tricks and tests. (15024897)
2003
22
Intermittent hyperaldosteronism in a child due to an adrenal adenoma. (11271382)
2001
23
Paraneoplastic hyperaldosteronism associated with non-Hodgkin's lymphoma. (11368052)
2001
24
The hypertensive patient with hypokalaemia: the search for hyperaldosteronism. (11390707)
2001
25
High prevalence of undiagnosed primary hyperaldosteronism among patients with essential hypertension]. (10668287)
1999
26
Primary hyperaldosteronism--12 clinical cases]. (10536470)
1999
27
A PCR-based method of screening individuals of all ages, from neonates to the elderly, for familial hyperaldosteronism type I. (9483237)
1997
28
Relative value of computed tomography scanning and venous sampling in establishing the cause of primary hyperaldosteronism. (8616527)
1996
29
Clinical, biochemical and genetic features of five extended kindred's with glucocorticoid-suppressible hyperaldosteronism. (7588411)
1995
30
Primary hyperaldosteronism. (8054042)
1993
31
Primary hyperaldosteronism: due to adrenal cortical carcinoma. (8323523)
1993
32
Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa. (7903825)
1993
33
Autosomal dominant polycystic kidney disease with primary hyperaldosteronism. (1323077)
1992
34
Diagnosis of primary hyperaldosteronism: importance of correlating CT findings with endocrinologic studies. (1738993)
1992
35
Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism. (1521363)
1992
36
Diagnosis under random conditions of all disorders of the renin-angiotensin-aldosterone axis, including primary hyperaldosteronism. (1939533)
1991
37
Secondary hyperaldosteronism stimulates acidification in rat distal colon. (2174145)
1990
38
Primary hyperaldosteronism. (2240013)
1990
39
Dexamethasone suppressible hyperaldosteronism: insights into adrenal physiology. (2154082)
1990
40
Normotensive glucocorticoid-suppressible hyperaldosteronism in adult. (2633910)
1989
41
A new variant of 17 alpha-hydroxylase deficiency with hyperaldosteronism in two Japanese sisters. (2550210)
1989
42
Mild adrenal 3 beta-hydroxysteroid dehydrogenase deficiency with hyperaldosteronism. (3220046)
1988
43
Long term evolution of glucocorticoid-suppressible hyperaldosteronism. (3536983)
1987
44
Long-term treatment of idiopathic hyperaldosteronism using trilostane. (3020849)
1986
45
Mineralocorticoid hypertension due to hyperaldosteronism and hyperdeoxycorticosteronism. (3553487)
1986
46
The pituitary and idiopathic hyperaldosteronism. (6547508)
1984
47
Primary hyperparathyroidism associated with primary hyperaldosteronism. (6349207)
1983
48
Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism. (7025545)
1981
49
Hyperreninemia and secondary hyperaldosteronism in pheochromocytomas. (762609)
1979
50
Clinical, biochemical and pathological features of low-renin ("primary") hyperaldosteronism. (622981)
1978

Genetic Variations for Hyperaldosteronism

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Expression for genes affiliated with Hyperaldosteronism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperaldosteronism

Search GEO for disease gene expression data for Hyperaldosteronism.

Pathways for genes affiliated with Hyperaldosteronism

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Compounds for genes affiliated with Hyperaldosteronism

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone44 2411.4CYP11B2, POMC, REN, CYP11B1
2hydralazine44 49 1112.4CYP11B2
3pcb 1264410.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
4deoxycorticosterone28 2411.3CYP21A2, CYP11B2, CYP11B1, NR3C2
521-deoxycortisol44 2411.3CYP21A2, CYP17A1, CYP11B2, CYP11B1, POMC
6metoclopramide44 1111.2CYP11B1, CYP11B2, NPPA, CYP17A1, REN
7cortisol28 2411.2CYP11B1, POMC, NR3C2, CYP11B2, CYP21A2
8benazepril44 1111.2ACE, REN, AGTR1, NPPA
9cilazapril44 1111.2NPPA, AGTR1, REN, ACE
10aldosterone28 11 2412.2CYP17A1, CYP11B2, CYP11B1, AGTR1, NR3C2
11trandolapril44 1111.2ACE, AGTR1, NPPA, REN
12eplerenone44 59 28 1113.2AGTR1, ACE, REN, NR3C2, CYP11B2
13metyrapone59 44 1112.2POMC, CYP21A2, CYP11B2, CYP11B1, NR3C2
14fosinopril44 1111.2ACE, REN, AGTR1, NPPA
1517-hydroxyprogesterone44 2411.2CYP21A2, CYP11B1, CYP17A1, POMC, REN, CYP11B2
16thiazide4410.1NR3C2, AGTR1, REN, SLC12A3, ACE
17cortisone44 2411.1AGTR1, CYP11B2, CYP11B1, POMC, CYP21A2, NR3C2
18fludrocortisone44 28 1112.1CYP21A2, CYP11B2, POMC, REN, NR3C2, NPPA
19felodipine44 28 1112.1AGTR1, NR3C2, REN, NPPA, ACE
20norepinephrine44 11 2412.1TH, CYP21A2, CYP11B2, POMC, KCNJ5, NR3C2
21nitroglycerin44 1111.1ACE, REN, AGTR1, NPPA, KCNJ5
223beta-hydroxysteroid4410.1NR3C2, CYP11B1, CYP11B2, CYP17A1, CYP21A2, POMC
23hydrochlorothiazide44 49 28 11 2414.1NR3C2, REN, ACE, SLC12A3, AGTR1, CYP11B2
24quinapril44 1111.1REN, ACE, AGTR1, NPPA
25androstenedione44 2411.1REN, CYP21A2, CYP17A1, CYP11B2, POMC, CYP11B1
26furosemide44 49 59 28 11 2415.1POMC, REN, NPPA, AGTR1, ACE, SLC12A3
27ang ii4410.1AGTR1, CYP11B2, REN, ACE, NR3C2, NPPA
28doca4410.0NR3C2, REN, CYP21A2, CYP17A1, CYP11B2, CYP11B1
2911 deoxycortisol4410.0REN, CYP21A2, CYP17A1, CYP11B2, CYP11B1, POMC
30lisinopril44 11 2412.0AGTR1, ACE, NPPA, REN
31losartan44 49 28 1113.0ACE, NPPA, NR3C2, AGTR1, CYP11B2, REN
32oxygen44 2411.0KCNJ5, CYP11B2, CYP11B1, CYP17A1, CYP21A2, NR3C2
33nifedipine44 49 28 1113.0CYP17A1, KCNJ5, ACE, REN, NPPA, AGTR1
34captopril44 28 49 59 1113.9NR3C2, REN, ACE, AGTR1, NPPA
35hydrocortisone44 2 59 1112.9NR3C2, POMC, CYP11B1, CYP11B2, CYP21A2, REN
3611beta-hydroxysteroid449.9CYP21A2, AGTR1, NR3C2, POMC, CYP11B1, CYP11B2
37catecholamine449.9REN, CYP21A2, TH, POMC, NR3C2, NPPA
38haloperidol44 28 2 49 1113.9KCNJ5, NR3C2, POMC, CYP11B2, REN, NPPA
39corticosterone44 59 2411.9CYP21A2, CYP17A1, REN, POMC, NR3C2, CYP11B2
40forskolin44 49 1111.9CYP11B2, POMC, CYP11B1, CYP17A1, REN, TH
41ramipril44 1110.8AGTR1, ACE, REN, NPPA
42acth449.7NPPA, REN, AGTR1, POMC, CYP11B2, CYP11B1
43spironolactone49 44 59 28 1113.7AGTR1, POMC, CYP11B1, CYP11B2, CYP21A2, REN
44atenolol44 28 49 11 2413.7ACE, REN, CYP11B2, AGTR1
45testosterone44 59 11 2412.6CYP11B2, CYP21A2, TH, KCNJ5, POMC, NR3C2
46potassium44 11 2411.5REN, KCNJ5, NPPA, NR3C2, AGTR1, CYP11B1
47sodium44 2410.5KCNJ5, NPPA, NR3C2, AGTR1, CYP11B1, REN
48dexamethasone44 49 28 1112.4CYP17A1, CYP21A2, REN, TH, CYP11B1, POMC
49arginine449.3NR3C2, AGTR1, NPPA, REN, CYP11B1, CYP11B2
50calcium44 49 11 2412.0ACE, CLCNKB, REN, SLC12A3, KCNJ5, NPPA

GO Terms for genes affiliated with Hyperaldosteronism

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16Gene Ontology
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Biological processes related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cortisol biosynthetic processGO:03465110.5CYP11B1, CYP11B2
2aldosterone biosynthetic processGO:03234210.5CYP11B1, CYP11B2
3renin-angiotensin regulation of aldosterone productionGO:00201810.5REN, AGTR1
4cellular response to potassium ionGO:03586510.5CYP11B1, CYP11B2
5mineralocorticoid biosynthetic processGO:00670510.4CYP21A2, CYP11B2, CYP11B1
6glucocorticoid biosynthetic processGO:00670410.4CYP11B1, CYP17A1, CYP21A2
7C21-steroid hormone biosynthetic processGO:00670010.4CYP11B1, CYP11B2
8phthalate metabolic processGO:01896310.4CYP17A1, TH
9regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3AGTR1, ACE
10sterol metabolic processGO:01612510.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
11steroid metabolic processGO:00820210.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
12response to herbicideGO:00963510.3TH, CYP17A1
13xenobiotic metabolic processGO:00680510.2CYP11B1, CYP11B2, CYP17A1, CYP21A2
14response to nutrient levelsGO:03166710.2TH, CYP17A1
15regulation of blood pressureGO:00821710.1NPPA, POMC, CYP11B1, REN, ACE
16regulation of vasodilationGO:04231210.1AGTR1, ACE
17kidney developmentGO:00182210.1ACE, REN, AGTR1
18angiotensin maturationGO:0020039.9ACE, REN

Molecular functions related to Hyperaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:00450710.3CYP11B2, CYP11B1
2bradykinin receptor bindingGO:03171110.2ACE, AGTR1
3electron carrier activityGO:00905510.0CYP21A2, CYP17A1, CYP11B2, CYP11B1
4heme bindingGO:0200379.9CYP11B1, CYP11B2, CYP17A1, CYP21A2
5iron ion bindingGO:0055069.7CYP11B1, CYP11B2, CYP17A1, CYP21A2

Products for genes affiliated with Hyperaldosteronism

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Sources for Hyperaldosteronism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet