MCID: HYP065
MIFTS: 49

Hyperaldosteronism malady

Genetic diseases, Endocrine diseases, Rare diseases, Cancer diseases categories

Aliases & Classifications for Hyperaldosteronism

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 25ICD10
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Hyperaldosteronism, Aliases & Descriptions:

Name: Hyperaldosteronism 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:446
ICD9CM27 255.1, 255.10
MeSH33 D006929
ICD1025 E26, E26.9

Summaries for Hyperaldosteronism

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Disease Ontology:9 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards based summary: Hyperaldosteronism is related to hypokalemia and kidney disease. An important gene associated with Hyperaldosteronism is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Steroid hormone biosynthesis and superpathway of steroid hormone biosynthesis. The drugs spironolactone and spironolactone pwdr and the compounds 18-oxocortisol and 18-hydroxycortisol have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and kidney, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Wikipedia:63 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

Related Diseases for Hyperaldosteronism

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Diseases in the Hyperaldosteronism family:

Hyperaldosteronism, Familial, Type Ii Hyperaldosteronism, Familial, Type Iii
Familial Hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1hypokalemia30.3CYP11B2, POMC, REN
2kidney disease30.3AGTR1, REN
3liddle syndrome30.2CYP11B2, REN
4adrenocortical carcinoma30.2CYP11B1, CYP11B2, POMC
5adenoma30.1POMC, REN, KCNJ5, CYP11B2, CYP11B1
6aldosteronism, glucocorticoid-remediable30.0CYP11B2, REN, POMC, CYP11B1
7atrial fibrillation30.0AGTR1, CYP11B2
8adrenal adenoma30.0CYP11B1, POMC, CYP11B2, REN
9conn's syndrome29.9CYP11B1, REN, CYP11B2, POMC, AGTR1
10congestive heart failure29.7CYP11B2, REN, AGTR1
11adrenal cortical adenoma29.6REN, AGTR1, POMC, CYP11B1
12myocardial infarction29.4KCNJ5, AGTR1, CYP11B2, REN
13cushing's syndrome29.2REN, CYP11B2, CYP11B1, POMC
14familial hyperaldosteronism10.8
15hyperaldosteronism, familial, type ii10.5
16hyperaldosteronism, familial, type iii10.5
17myocardial stunning10.4KCNJ5
18hyperparathyroidism10.3
19fibromuscular dysplasia10.3REN
20portal hypertension10.3REN
21pheochromocytoma10.3
22adrenal cortical carcinoma10.3
23acute adrenal insufficiency10.3POMC
24primary hyperparathyroidism10.2
25bartter syndrome, type 310.2
26myopathy10.2
27renal tubular dysgenesis10.1AGTR1, REN
28renovascular hypertension10.1AGTR1, REN
29coronary artery disease10.1KCNJ5, AGTR1
30renal fibrosis10.1AGTR1, REN
31hyperprolactinemia10.1
32cystic fibrosis10.1
33apparent mineralocorticoid excess10.1
34bartter disease10.1
35oculocerebrorenal syndrome10.1
36polyarteritis nodosa10.1
37polycystic kidney disease10.1
38adrenal carcinoma10.1
39peritonitis10.1
40sleep apnea10.1
41bartter syndrome type 410.1
42endotheliitis10.1
43bartter syndrome with hypocalcemia10.1
44antenatal bartter syndrome10.1
45congenital heart disease10.1KCNJ5, AGTR1
46glomerulosclerosis10.0REN, AGTR1
47precocious puberty10.0POMC, CYP11B1
48acute myocardial infarction10.0AGTR1, KCNJ5
49hypoglycemia10.0KCNJ5, POMC
50microvascular complications of diabetes 310.0REN, AGTR1

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to hyperaldosteronism

Symptoms for Hyperaldosteronism

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Drugs & Therapeutics for Hyperaldosteronism

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Drug clinical trials:

Search ClinicalTrials for Hyperaldosteronism

Search NIH Clinical Center for Hyperaldosteronism

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hyperaldosteronism

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Anatomical Context for Hyperaldosteronism

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MalaCards organs/tissues related to Hyperaldosteronism:

31
Adrenal gland, Testes, Kidney, Heart, Pituitary, Cortex, Adrenal cortex, Colon, Endothelial, Liver, Skin, Hypothalamus

Animal Models for Hyperaldosteronism or affiliated genes

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MGI Mouse Phenotypes related to Hyperaldosteronism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5AGTR1, REN, POMC, CYP11B1, CYP11B2
2MP:00053677.4CYP11B2, CYP11B1, POMC, REN, AGTR1
3MP:00053787.2CYP11B2, CYP11B1, POMC, REN, AGTR1
4MP:00053857.1AGTR1, REN, POMC, KCNJ5, CYP11B1, CYP11B2

Publications for Hyperaldosteronism

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Articles related to Hyperaldosteronism:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Hyperaldosteronism as a common cause of resistant hypertension. (23092384)
2013
2
Image-guided ablation of Conn's adenomas in the management of primary hyperaldosteronism. (23218647)
2013
3
The Vascular Surgeon's Experience with Adrenal Venous Sampling for the Diagnosis of Primary Hyperaldosteronism. (24355161)
2013
4
Outcome of Surgery for Primary Hyperaldosteronism. (22286966)
2012
5
The clinical utility of two renin mass methods to detect primary hyperaldosteronism compared with renin activity. (21427267)
2011
6
Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism. (20339375)
2010
7
Hyperaldosteronism in an adolescent with Gardner's syndrome. (19433155)
2009
8
Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma. (19180717)
2008
9
Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism. (18312153)
2008
10
Primary hyperaldosteronism in patients with resistant hypertension may be less prevalent than previously reported: evidence against an epidemic. (18780479)
2008
11
Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families. (18622235)
2008
12
Noninvasive adrenal imaging in hyperaldosteronism. (18366979)
2008
13
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. (18307725)
2008
14
Primary hyperaldosteronism: returning to the limelight? (17541333)
2007
15
High frequency of primary hyperaldosteronism among hypertensive patients from a primary care area in Sweden. (16923624)
2006
16
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
17
Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. (15745200)
2005
18
Comparison of active renin concentration and plasma renin activity for the diagnosis of primary hyperaldosteronism in patients with an adrenal mass. (15080782)
2004
19
Hypokalemic quadriparesis with normotensive primary hyperaldosteronism. (15321042)
2004
20
Primary hyperaldosteronism. (14503982)
2003
21
Does the treatment of primary hyperaldosteronism influence glucose tolerance? (12899664)
2003
22
Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension. (10999827)
2000
23
Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. (10843166)
2000
24
Laparoscopic vs open adrenalectomy for the treatment of primary hyperaldosteronism. (10367872)
1999
25
Bilateral adrenal cortical adenomas in primary hyperaldosteronism. (9763101)
1998
26
Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism. (9380281)
1997
27
Hyperaldosteronism and sudden cardiac death. (8806357)
1996
28
Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism]. (8949378)
1996
29
Primary hyperaldosteronism in pregnancy. A case report. (8728078)
1996
30
Restoration by corticosteroids of the hyperaldosteronism in hyponatraemic rats with panhypopituitarism. (7834996)
1994
31
Chronic sennoside treatment does not cause habituation and secondary hyperaldosteronism in rats. (8234425)
1993
32
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity. (1472060)
1992
33
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
34
Secondary hyperaldosteronism stimulates acidification in rat distal colon. (2174145)
1990
35
Study on clinical and endocrine characteristics of dexamethasone-suppressible hyperaldosteronism compared with those in primary aldosteronism owing to aldosterone-producing adenoma. (2552725)
1989
36
Dexamethasone-suppressible hyperaldosteronism: pathophysiology, clinical aspects, and new insights into the pathogenesis. (3037179)
1987
37
Aldosterone receptors in different types of primary hyperaldosteronism. (3034947)
1987
38
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. (3012766)
1986
39
Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with essential low-renin hypertension and idiopathic hyperaldosteronism. (3882312)
1985
40
Primary adrenal hyperplasia: a new subset of primary hyperaldosteronism. (6707184)
1984
41
Effect of chronic hyperaldosteronism on the electrophysiology of rat distal colon. (6089088)
1984
42
Primary hyperparathyroidism associated with primary hyperaldosteronism. (6349207)
1983
43
Effect of standard oral glucose loading on aldosterone secretion in primary hyperaldosteronism. (6751010)
1982
44
Hyperaldosteronism in ketoacidosis and in poorly controlled non-ketotic diabetes. (6809687)
1982
45
Adrenal glomerulosa function in patients with dexamethasone-suppressible hyperaldosteronism. (7016891)
1981
46
Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism. (6987607)
1980
47
Primary hyperparathyroidism: possible cause of primary hyperaldosteronism in a 60-year-old woman. (6991517)
1980
48
Acute intermittent porphyria associated with inappropriate antidiuretic hormone secretion, hypokalemic alkalosis, and secondary hyperaldosteronism. (472850)
1979
49
Hyperreninemia and secondary hyperaldosteronism in pheochromocytomas. (762609)
1979
50
Differentiation between subtypes of primary hyperaldosteronism by multiple steroid measurement after dexamethasone administration. (713414)
1978

Variations for Hyperaldosteronism

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Expression for genes affiliated with Hyperaldosteronism

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Search GEO for disease gene expression data for Hyperaldosteronism.

Pathways for genes affiliated with Hyperaldosteronism

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Pathways related to Hyperaldosteronism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.5CYP11B2, CYP11B1
2
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
9.5CYP11B2, CYP11B1
39.2POMC, CYP11B1
4
Show member pathways
9.0REN, POMC
5
Show member pathways
8.8AGTR1, REN, CYP11B2
6
Show member pathways
8.7POMC, CYP11B1, CYP11B2
7
Show member pathways
8.7POMC, CYP11B1, CYP11B2
8
Show member pathways
8.7CYP11B2, CYP11B1, POMC

Compounds for genes affiliated with Hyperaldosteronism

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Compounds related to Hyperaldosteronism according to GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
118-oxocortisol439.8CYP11B1, CYP11B2
218-hydroxycortisol439.8CYP11B1, CYP11B2
319-oic-deoxycorticosterone249.8CYP11B2, CYP11B1
419-Hydroxydeoxycorticosterone249.7CYP11B2, CYP11B1
519-Oxo-deoxycorticosterone249.7CYP11B2, CYP11B1
618-hydroxydeoxycorticosterone439.7CYP11B2, CYP11B1
711b-Hydroxyprogesterone249.5CYP11B2, CYP11B1
8aldosterone28 24 1211.4CYP11B2, CYP11B1, AGTR1
9tetrahydroaldosterone439.3CYP11B2, REN
10nitroglycerin43 1210.2KCNJ5, REN, AGTR1
11metoclopramide43 49 1211.2REN, CYP11B2, CYP11B1
12eplerenone43 59 28 1212.2REN, AGTR1, CYP11B2
13benazepril43 49 1211.2CYP11B2, AGTR1, REN
1411beta-Hydroxyprogesterone249.2CYP11B2, CYP11B1
15hydralazine43 49 1211.2CYP11B2, REN, AGTR1
16atenolol43 49 28 24 1213.2CYP11B2, REN, AGTR1
17irbesartan43 28 49 1212.2AGTR1, REN, CYP11B2
18candesartan43 49 28 1212.1AGTR1, REN, CYP11B2
19hydrochlorothiazide43 28 49 24 1213.1CYP11B2, REN, AGTR1
2021-deoxycortisol43 2410.1CYP11B1, POMC, CYP11B2
21ang ii439.1REN, AGTR1, CYP11B2
22etomidate43 1210.1CYP11B1, CYP11B2, POMC
23cortisol28 2410.1POMC, CYP11B1, CYP11B2
24metyrapone43 59 1211.0CYP11B1, POMC, CYP11B2
25methacholine43 49 1211.0REN, KCNJ5, AGTR1
26fludrocortisone43 28 1210.9REN, POMC, CYP11B2
273beta-hydroxysteroid438.9CYP11B2, CYP11B1, POMC
28furosemide43 59 28 49 24 1213.8REN, AGTR1, POMC
29nifedipine43 28 49 1211.8KCNJ5, REN, AGTR1, CYP11B2
30cortisone43 249.6AGTR1, POMC, CYP11B1, CYP11B2
31clonidine43 49 28 1211.6REN, POMC, AGTR1
3218-hydroxycorticosterone43 249.5POMC, REN, CYP11B1, CYP11B2
3311 deoxycortisol438.5CYP11B1, REN, POMC, CYP11B2
34doca438.5CYP11B1, REN, POMC, CYP11B2
3517-hydroxyprogesterone43 249.5REN, POMC, CYP11B1, CYP11B2
36androstenedione43 249.5CYP11B2, CYP11B1, POMC, REN
37corticosterone43 59 2410.5POMC, CYP11B2, REN, CYP11B1
38hydrocortisone43 2 59 1211.4CYP11B2, CYP11B1, POMC, REN
39potassium43 24 1210.4CYP11B2, KCNJ5, REN, AGTR1, CYP11B1
40sodium43 249.3AGTR1, KCNJ5, CYP11B1, CYP11B2, REN
41haloperidol43 49 28 2 1212.0AGTR1, POMC, CYP11B2, KCNJ5, REN
42norepinephrine43 24 1210.0REN, AGTR1, POMC, KCNJ5, CYP11B2
43spironolactone43 59 28 49 1212.0CYP11B1, CYP11B2, POMC, AGTR1, REN
4411beta-hydroxysteroid438.0AGTR1, REN, POMC, CYP11B1, CYP11B2
45acth438.0REN, POMC, CYP11B1, CYP11B2, AGTR1
46estradiol43 24 1210.0POMC, CYP11B1, REN, AGTR1
47forskolin43 49 129.9REN, CYP11B2, AGTR1, CYP11B1, POMC
48dexamethasone43 49 28 1210.9POMC, CYP11B1, REN, AGTR1, CYP11B2
49arginine437.9CYP11B1, CYP11B2, REN, AGTR1, POMC
50glucose437.7AGTR1, CYP11B2, KCNJ5, POMC, REN

GO Terms for genes affiliated with Hyperaldosteronism

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Biological processes related to Hyperaldosteronism according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cortisol biosynthetic processGO:00346519.7CYP11B2, CYP11B1
2aldosterone biosynthetic processGO:00323429.7CYP11B2, CYP11B1
3mineralocorticoid biosynthetic processGO:00067059.7CYP11B1, CYP11B2
4cellular response to potassium ionGO:00358659.6CYP11B2, CYP11B1
5C21-steroid hormone biosynthetic processGO:00067009.6CYP11B1, CYP11B2
6sterol metabolic processGO:00161259.6CYP11B1, CYP11B2
7renin-angiotensin regulation of aldosterone productionGO:00020189.5AGTR1, REN
8cellular response to hormone stimulusGO:00328709.5CYP11B2, CYP11B1
9xenobiotic metabolic processGO:00068059.5CYP11B1, CYP11B2
10steroid metabolic processGO:00082029.4CYP11B1, CYP11B2
11kidney developmentGO:00018229.0AGTR1, REN
12regulation of blood pressureGO:00082178.8REN, POMC, CYP11B1

Molecular functions related to Hyperaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.5CYP11B1, CYP11B2
2steroid 11-beta-monooxygenase activityGO:00045079.2CYP11B1, CYP11B2

Products for genes affiliated with Hyperaldosteronism

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Sources for Hyperaldosteronism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet