MCID: HYP065
MIFTS: 59

Hyperaldosteronism malady

Endocrine diseases category

Summaries for Hyperaldosteronism

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards: Hyperaldosteronism is related to hypertension and adenoma. An important gene associated with Hyperaldosteronism is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Insulin Processing and Cytochrome P450 - arranged by substrate type. The drugs spironolactone and spironolactone pwdr and the compounds 18-hydroxycorticosterone and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia:63 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

Aliases & Classifications for Hyperaldosteronism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hyperaldosteronism 8 10 44 60


External Ids:

Disease Ontology8 DOID:446
ICD9CM27 255.10, 255.1
MeSH34 D006929
ICD1025 E26, E26.0, E26.9

Related Diseases for Hyperaldosteronism

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Familial Hyperaldosteronism Type 2 family:

hyperaldosteronism Hyperaldosteronism, Familial, Type Iii
Familial Hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1NPPA, AGTR1, POMC, CYP11B2, CYP17A1, TH
2adenoma30.9CYP11B1, NR3C2, MEN1, POMC, KCNJ5, PMS2
3adrenal adenoma30.7POMC, CYP11B1, CYP17A1, CYP21A2, REN, AGTR1
4conn's syndrome30.6NPPA, NR3C2, AGTR1, REN, POMC, CYP11B1
5essential hypertension30.6NPPA, NR3C2, AGTR1, CYP11B1, CYP11B2, REN
6hypokalemia30.5CYP17A1, REN, CLCNKB, SLC12A3, ACE, CYP11B2
7adrenal carcinoma30.5POMC
8glucocorticoid-remediable aldosteronism30.5NR3C2, CYP11B1, REN, CYP11B2, POMC
9hyperparathyroidism30.4MEN1
10pheochromocytoma30.3MEN1, POMC, NPPA, TH
11adrenocortical carcinoma30.3CYP11B1, AGTR1, POMC, CYP21A2, CYP17A1, CYP11B2
12apparent mineralocorticoid excess syndrome30.0NR3C2
13bartter syndrome type 330.0SLC12A3, CLCNKB, REN
14cushing's syndrome30.0POMC, NR3C2
15hypothyroidism29.8POMC
16vitiligo29.8POMC
17malignant hypertension29.8REN, ACE
18renal hypertension29.8ACE, REN
19nephrosclerosis29.8ACE, NR3C2, AGTR1
20pseudohypoaldosteronism29.8NR3C2, SLC12A3, REN, CYP21A2
21congestive heart failure29.8NPPA, REN, CYP11B2, ACE, AGTR1, NR3C2
22diabetes mellitus29.7ACE, AGTR1, NR3C2, NPPA, KCNJ5, POMC
23familial hyperaldosteronism type 210.4
24familial hyperaldosteronism10.4
25hyperaldosteronism, familial, type iii10.3
26primary hyperparathyroidism10.2
27bartter syndrome, type 210.2
28kidney disease10.1
29myopathy10.1
30cystic fibrosis10.0
31hyperprolactinemia10.0
32polyarteritis nodosa10.0
33polycystic kidney disease10.0
34autosomal dominant disease10.0
35peritonitis10.0
36renal adenoma10.0
37polycystic kidney disease, autosomal dominant10.0
38hypocalcemia, autosomal dominant10.0
39bartter syndrome type 4a10.0
40diabetes insipidus10.0POMC
41fibromuscular dysplasia10.0REN
42mitral valve prolapse10.0AGTR1
43uremia10.0MEN1
44mitral valve disease10.0NPPA
45anuria10.0ACE
46lung cancer10.0POMC
47panic disorder10.0POMC
48hypoglycemia10.0KCNJ5, POMC
49thyroiditis10.0POMC
50glomerulonephritis10.0AGTR1

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to hyperaldosteronism

Clinical Features for Hyperaldosteronism

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Drugs & Therapeutics for Hyperaldosteronism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperaldosteronism

Drug clinical trials:

Search ClinicalTrials for Hyperaldosteronism

Search NIH Clinical Center for Hyperaldosteronism

Search CenterWatch for Hyperaldosteronism

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperaldosteronism

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Anatomical Context for Hyperaldosteronism

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32MalaCards
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MalaCards organs/tissues related to Hyperaldosteronism:

32
Adrenal gland, Testes, Kidney, Pituitary, Heart, Cortex, Adrenal cortex, Endothelial, Colon, Liver, Skin, Hypothalamus

Animal Models for Hyperaldosteronism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperaldosteronism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7PMS2, MEN1, CYP11B1, CYP11B2
2MP:00053979.3REN, GNA12, PMS2, NPPA, NR3C2, POMC
3MP:00053679.3NPPA, NR3C2, AGTR1, POMC, CYP11B1, REN
4MP:00107688.8MEN1, NR3C2, PMS2, AGTR1, ACE, POMC
5MP:00053858.8ACE, KCNJ5, GNA12, NPPA, MEN1, NR3C2
6MP:00053768.4MEN1, NR3C2, AGTR1, POMC, CYP11B1, CYP11B2

Publications for Hyperaldosteronism

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Sources:
50PubMed
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Articles related to Hyperaldosteronism:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Hyperaldosteronism as a common cause of resistant hypertension. (23092384)
2013
2
The Vascular Surgeon's Experience with Adrenal Venous Sampling for the Diagnosis of Primary Hyperaldosteronism. (24355161)
2013
3
Adrenal histologic findings show no difference in clinical presentation and outcome in primary hyperaldosteronism. (23090573)
2013
4
The history of primary hyperaldosteronism with simultaneous hypercortisolism. (22236975)
2012
5
Primary hyperaldosteronism: expanding the diagnostic net. (21872791)
2011
6
Prevalence and characteristics of familial hyperaldosteronism: the PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms). (21876069)
2011
7
Hyperaldosteronism in Klotho-deficient mice. (20719979)
2010
8
Feline primary hyperaldosteronism. (20219494)
2010
9
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. (20354176)
2010
10
Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC. (19494170)
2009
11
Malignant aldosterone-producing adrenal tumour: reoccurrence with glucocorticoid excess without hyperaldosteronism. (18689909)
2008
12
The role of radiologic studies in the evaluation and management of primary hyperaldosteronism. (19040999)
2008
13
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
14
Ventricular fibrillation as the first manifestation of primary hyperaldosteronism. (19610566)
2006
15
Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. (15745200)
2005
16
Hyperaldosteronism and hypertension: ethnic differences. (15699471)
2005
17
Hyperaldosteronism and hyperprogesteronism in a cat with an adrenal cortical carcinoma. (15954552)
2005
18
A case of insulin edema with inappropriate hyperaldosteronism. (15762045)
2004
19
Normokalemic hyperaldosteronism in patients with resistant hypertension. (11802302)
2002
20
Hyperaldosteronism: recent concepts, diagnosis, and management. (11571370)
2001
21
In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion. (11731622)
2001
22
A chimeric CYP11B1/CYP11B2 gene in glucocorticoid-insuppressible familial hyperaldosteronism. (11453962)
2001
23
A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22). (11073536)
2000
24
Laparoscopic adrenalectomy is superior to an open approach to treat primary hyperaldosteronism. (11261619)
2000
25
Role of dietary potassium in the hyperaldosteronism and hypertension of the remnant kidney model. (10752521)
2000
26
Use of abdominal ultrasonography in the diagnosis of primary hyperaldosteronism in a cat. (10909461)
2000
27
Biochemical evidence of aldosterone overproduction and abnormal regulation in normotensive individuals with familial hyperaldosteronism type I. (10566645)
1999
28
Effect of the serotonin4 receptor agonist cisapride on plasma aldosterone levels in cirrhotic patients with secondary hyperaldosteronism. (9551708)
1998
29
Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism]. (8949378)
1996
30
11 beta-Hydroxylase activity in glucocorticoid suppressible hyperaldosteronism: lessons for essential hypertension? (8969929)
1996
31
Dexamethasone-suppressible hyperaldosteronism: clinical, biochemical and genetic relations. (7473536)
1995
32
Clinical, biochemical and genetic approaches to the detection of familial hyperaldosteronism type I. (8903619)
1995
33
Prohormones in adrenal venous effluent in patients with primary hyperaldosteronism. (7745017)
1995
34
Screening of a population of young hypertensives for primary hyperaldosteronism. (7807506)
1994
35
Primary hyperaldosteronism--evaluation of procedures for diagnosis and localization. (8171186)
1993
36
Twenty-four-hour power spectral analysis by maximum entropy method of blood pressure in primary hyperaldosteronism. (8205312)
1993
37
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity. (1472060)
1992
38
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
39
Concurrent hypercortisolism and hyperaldosteronism due to an adrenal adenoma. (2232630)
1990
40
Elevated sweat potassium, hyperaldosteronism and pseudo-Bartter's syndrome: a spectrum of disorders associated with cystic fibrosis. (2724265)
1989
41
Dexamethasone-suppressible hyperaldosteronism: a large new kindred. (2552113)
1989
42
The value of scintigraphy and computed tomography for the differential diagnosis of primary hyperaldosteronism. (3766043)
1986
43
Aminoglutethimide effect on circadian rhythms in urinary variables in a patient with idiopathic hyperaldosteronism. (3996107)
1985
44
Idiopathic hyperaldosteronism. A possible role for aldosterone-stimulating factor. (6330549)
1984
45
Primary hyperaldosteronism: comparison of CT, adrenal venography, and venous sampling. (6603122)
1983
46
Cystic fibrosis presenting with chronic electrolyte depletion, metabolic alkalosis and hyperaldosteronism. (7146884)
1982
47
Converting enzyme inhibition with captopril in patients with primary hyperaldosteronism. (6277545)
1982
48
Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis. (6277130)
1982
49
The acute effect of angiotensin II on adrenal and anterior pituitary function in normal subjects and subjects with primary hyperaldosteronism. (6259651)
1980
50
Effect of posture on the plasma concentrations of aldosterone in hypertension and primary hyperaldosteronism. (220544)
1979

Genetic Variations for Hyperaldosteronism

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Expression for genes affiliated with Hyperaldosteronism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperaldosteronism

Search GEO for disease gene expression data for Hyperaldosteronism.

Pathways for genes affiliated with Hyperaldosteronism

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Compounds for genes affiliated with Hyperaldosteronism

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone44 2411.4CYP11B2, POMC, REN, CYP11B1
2hydralazine44 49 1112.4CYP11B2
3pcb 1264410.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
4deoxycorticosterone28 2411.3CYP21A2, CYP11B2, CYP11B1, NR3C2
521-deoxycortisol44 2411.3CYP21A2, CYP17A1, CYP11B2, CYP11B1, POMC
6metoclopramide44 1111.2CYP11B1, CYP11B2, NPPA, CYP17A1, REN
7cortisol28 2411.2CYP11B1, POMC, NR3C2, CYP11B2, CYP21A2
8benazepril44 1111.2ACE, REN, AGTR1, NPPA
9cilazapril44 1111.2NPPA, AGTR1, REN, ACE
10aldosterone28 11 2412.2CYP17A1, CYP11B2, CYP11B1, AGTR1, NR3C2
11trandolapril44 1111.2ACE, AGTR1, NPPA, REN
12eplerenone44 59 28 1113.2AGTR1, ACE, REN, NR3C2, CYP11B2
13metyrapone59 44 1112.2POMC, CYP21A2, CYP11B2, CYP11B1, NR3C2
14fosinopril44 1111.2ACE, REN, AGTR1, NPPA
1517-hydroxyprogesterone44 2411.2CYP21A2, CYP11B1, CYP17A1, POMC, REN, CYP11B2
16thiazide4410.1NR3C2, AGTR1, REN, SLC12A3, ACE
17cortisone44 2411.1AGTR1, CYP11B2, CYP11B1, POMC, CYP21A2, NR3C2
18fludrocortisone44 28 1112.1CYP21A2, CYP11B2, POMC, REN, NR3C2, NPPA
19felodipine44 28 1112.1AGTR1, NR3C2, REN, NPPA, ACE
20norepinephrine44 11 2412.1TH, CYP21A2, CYP11B2, POMC, KCNJ5, NR3C2
21nitroglycerin44 1111.1ACE, REN, AGTR1, NPPA, KCNJ5
223beta-hydroxysteroid4410.1NR3C2, CYP11B1, CYP11B2, CYP17A1, CYP21A2, POMC
23hydrochlorothiazide44 49 28 11 2414.1NR3C2, REN, ACE, SLC12A3, AGTR1, CYP11B2
24quinapril44 1111.1REN, ACE, AGTR1, NPPA
25androstenedione44 2411.1REN, CYP21A2, CYP17A1, CYP11B2, POMC, CYP11B1
26furosemide44 49 59 28 11 2415.1POMC, REN, NPPA, AGTR1, ACE, SLC12A3
27ang ii4410.1AGTR1, CYP11B2, REN, ACE, NR3C2, NPPA
28doca4410.0NR3C2, REN, CYP21A2, CYP17A1, CYP11B2, CYP11B1
2911 deoxycortisol4410.0REN, CYP21A2, CYP17A1, CYP11B2, CYP11B1, POMC
30lisinopril44 11 2412.0AGTR1, ACE, NPPA, REN
31losartan44 49 28 1113.0ACE, NPPA, NR3C2, AGTR1, CYP11B2, REN
32oxygen44 2411.0KCNJ5, CYP11B2, CYP11B1, CYP17A1, CYP21A2, NR3C2
33nifedipine44 49 28 1113.0CYP17A1, KCNJ5, ACE, REN, NPPA, AGTR1
34captopril44 28 49 59 1113.9NR3C2, REN, ACE, AGTR1, NPPA
35hydrocortisone44 2 59 1112.9NR3C2, POMC, CYP11B1, CYP11B2, CYP21A2, REN
3611beta-hydroxysteroid449.9CYP21A2, AGTR1, NR3C2, POMC, CYP11B1, CYP11B2
37catecholamine449.9REN, CYP21A2, TH, POMC, NR3C2, NPPA
38haloperidol44 28 2 49 1113.9KCNJ5, NR3C2, POMC, CYP11B2, REN, NPPA
39corticosterone44 59 2411.9CYP21A2, CYP17A1, REN, POMC, NR3C2, CYP11B2
40forskolin44 49 1111.9CYP11B2, POMC, CYP11B1, CYP17A1, REN, TH
41ramipril44 1110.8AGTR1, ACE, REN, NPPA
42acth449.7NPPA, REN, AGTR1, POMC, CYP11B2, CYP11B1
43spironolactone49 44 59 28 1113.7AGTR1, POMC, CYP11B1, CYP11B2, CYP21A2, REN
44atenolol44 28 49 11 2413.7ACE, REN, CYP11B2, AGTR1
45testosterone44 59 11 2412.6CYP11B2, CYP21A2, TH, KCNJ5, POMC, NR3C2
46potassium44 11 2411.5REN, KCNJ5, NPPA, NR3C2, AGTR1, CYP11B1
47sodium44 2410.5KCNJ5, NPPA, NR3C2, AGTR1, CYP11B1, REN
48dexamethasone44 49 28 1112.4CYP17A1, CYP21A2, REN, TH, CYP11B1, POMC
49arginine449.3NR3C2, AGTR1, NPPA, REN, CYP11B1, CYP11B2
50calcium44 49 11 2412.0ACE, CLCNKB, REN, SLC12A3, KCNJ5, NPPA

GO Terms for genes affiliated with Hyperaldosteronism

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16Gene Ontology
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Biological processes related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cortisol biosynthetic processGO:03465110.5CYP11B1, CYP11B2
2aldosterone biosynthetic processGO:03234210.5CYP11B1, CYP11B2
3renin-angiotensin regulation of aldosterone productionGO:00201810.5REN, AGTR1
4cellular response to potassium ionGO:03586510.5CYP11B1, CYP11B2
5mineralocorticoid biosynthetic processGO:00670510.4CYP21A2, CYP11B2, CYP11B1
6glucocorticoid biosynthetic processGO:00670410.4CYP11B1, CYP17A1, CYP21A2
7C21-steroid hormone biosynthetic processGO:00670010.4CYP11B1, CYP11B2
8phthalate metabolic processGO:01896310.4CYP17A1, TH
9regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3AGTR1, ACE
10sterol metabolic processGO:01612510.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
11steroid metabolic processGO:00820210.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
12response to herbicideGO:00963510.3TH, CYP17A1
13xenobiotic metabolic processGO:00680510.2CYP11B1, CYP11B2, CYP17A1, CYP21A2
14response to nutrient levelsGO:03166710.2TH, CYP17A1
15regulation of blood pressureGO:00821710.1NPPA, POMC, CYP11B1, REN, ACE
16regulation of vasodilationGO:04231210.1AGTR1, ACE
17kidney developmentGO:00182210.1ACE, REN, AGTR1
18angiotensin maturationGO:0020039.9ACE, REN

Molecular functions related to Hyperaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:00450710.3CYP11B2, CYP11B1
2bradykinin receptor bindingGO:03171110.2ACE, AGTR1
3electron carrier activityGO:00905510.0CYP11B1, CYP17A1, CYP21A2, CYP11B2
4heme bindingGO:0200379.9CYP11B1, CYP11B2, CYP21A2, CYP17A1
5iron ion bindingGO:0055069.7CYP17A1, CYP11B2, CYP11B1, CYP21A2

Products for genes affiliated with Hyperaldosteronism

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  • Antibodies
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Sources for Hyperaldosteronism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet