MCID: HYP065
MIFTS: 58

Hyperaldosteronism malady

Genetic diseases, Endocrine diseases, Rare diseases, Cancer diseases categories
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Summaries for Hyperaldosteronism

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Disease Ontology:8 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards based summary: Hyperaldosteronism is related to low renin hypertension and hypokalemia. An important gene associated with Hyperaldosteronism is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Steroid hormone biosynthesis and superpathway of steroid hormone biosynthesis. The drugs spironolactone and spironolactone pwdr and the compounds 18-oxocortisol and 18-hydroxycortisol have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and kidney, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Wikipedia:65 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

Aliases & Classifications for Hyperaldosteronism

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Hyperaldosteronism, Aliases & Descriptions:

Name: Hyperaldosteronism 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:446
ICD9CM27 255.1, 255.10
MeSH34 D006929
ICD1025 E26, E26.0, E26.9

Related Diseases for Hyperaldosteronism

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Diseases in the Hyperaldosteronism, Familial, Type Iii family:

hyperaldosteronism Familial Hyperaldosteronism Type 2
Familial Hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1low renin hypertension30.5REN, CYP11B2
2hypokalemia30.3CYP11B2, POMC, REN
3hypertension30.3CYP11B2, CYP11B1, POMC, REN, AGTR1
4essential hypertension30.3CYP11B2, CYP11B1, REN, AGTR1
5liddle syndrome30.3REN, CYP11B2
6adrenocortical carcinoma30.2POMC, CYP11B1, CYP11B2
7adenoma30.2CYP11B2, CYP11B1, KCNJ5, POMC, REN
8glucocorticoid-remediable aldosteronism30.0REN, POMC, CYP11B1, CYP11B2
9adrenal adenoma30.0CYP11B2, CYP11B1, POMC, REN
10conn's syndrome29.9CYP11B2, CYP11B1, POMC, REN, AGTR1
11congestive heart failure29.7AGTR1, REN, CYP11B2
12adrenal cortical adenoma29.6CYP11B1, POMC, REN, AGTR1
13cushing's syndrome29.3REN, POMC, CYP11B1, CYP11B2
14diabetes mellitus29.3KCNJ5, POMC, REN, AGTR1
15familial hyperaldosteronism10.8
16familial hyperaldosteronism type 210.5
17hyperaldosteronism, familial, type iii10.4
18myocardial stunning10.4KCNJ5
19fibromuscular dysplasia10.3REN
20hyperparathyroidism10.3
21portal hypertension10.3REN
22pheochromocytoma10.3
23acute adrenal insufficiency10.3POMC
24primary hyperparathyroidism10.2
25bartter syndrome, type 210.2
26kidney disease10.2
27myopathy10.2
28renal tubular dysgenesis10.1REN, AGTR1
29renovascular hypertension10.1REN, AGTR1
30coronary artery anomaly10.1KCNJ5, AGTR1
31renal fibrosis10.1REN, AGTR1
32cystic fibrosis10.1
33apparent mineralocorticoid excess syndrome10.1
34polycystic kidney disease10.1
35polyarteritis nodosa10.1
36hyperprolactinemia10.1
37adrenal carcinoma10.1
38peritonitis10.1
39sleep apnea10.1
40bartter syndrome type 310.1
41hypocalcemia, autosomal dominant10.1
42bartter syndrome type 4a10.1
43endotheliitis10.1
44glomerulosclerosis10.1AGTR1, REN
45congenital heart disease10.1AGTR1, KCNJ5
46primary hyperoxaluria10.0AGTR1, REN
47precocious puberty10.0POMC, CYP11B1
48septic shock10.0POMC, KCNJ5
49acute myocardial infarction10.0AGTR1, KCNJ5
50hypoglycemia10.0KCNJ5, POMC

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to hyperaldosteronism

Symptoms for Hyperaldosteronism

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Drugs & Therapeutics for Hyperaldosteronism

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Drug clinical trials:

Search ClinicalTrials for Hyperaldosteronism

Search NIH Clinical Center for Hyperaldosteronism

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Hyperaldosteronism

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Anatomical Context for Hyperaldosteronism

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MalaCards organs/tissues related to Hyperaldosteronism:

32
Adrenal gland, Testes, Kidney, Heart, Pituitary, Cortex, Adrenal cortex, Colon, Endothelial, Liver, Skin, Hypothalamus

Animal Models for Hyperaldosteronism or affiliated genes

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MGI Mouse Phenotypes related to Hyperaldosteronism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5AGTR1, REN, POMC, CYP11B1, CYP11B2
2MP:00053677.4CYP11B2, CYP11B1, POMC, REN, AGTR1
3MP:00053787.2CYP11B2, CYP11B1, POMC, REN, AGTR1
4MP:00053857.1AGTR1, REN, POMC, KCNJ5, CYP11B1, CYP11B2

Publications for Hyperaldosteronism

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Articles related to Hyperaldosteronism:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Hyperaldosteronism as a common cause of resistant hypertension. (23092384)
2013
2
Image-guided ablation of Conn's adenomas in the management of primary hyperaldosteronism. (23218647)
2013
3
The Vascular Surgeon's Experience with Adrenal Venous Sampling for the Diagnosis of Primary Hyperaldosteronism. (24355161)
2013
4
Outcome of Surgery for Primary Hyperaldosteronism. (22286966)
2012
5
The clinical utility of two renin mass methods to detect primary hyperaldosteronism compared with renin activity. (21427267)
2011
6
Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism. (20339375)
2010
7
Hyperaldosteronism in an adolescent with Gardner's syndrome. (19433155)
2009
8
Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma. (19180717)
2008
9
Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism. (18312153)
2008
10
Primary hyperaldosteronism in patients with resistant hypertension may be less prevalent than previously reported: evidence against an epidemic. (18780479)
2008
11
Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families. (18622235)
2008
12
Noninvasive adrenal imaging in hyperaldosteronism. (18366979)
2008
13
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. (18307725)
2008
14
Primary hyperaldosteronism: returning to the limelight? (17541333)
2007
15
High frequency of primary hyperaldosteronism among hypertensive patients from a primary care area in Sweden. (16923624)
2006
16
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
17
Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. (15745200)
2005
18
Comparison of active renin concentration and plasma renin activity for the diagnosis of primary hyperaldosteronism in patients with an adrenal mass. (15080782)
2004
19
Hypokalemic quadriparesis with normotensive primary hyperaldosteronism. (15321042)
2004
20
Primary hyperaldosteronism. (14503982)
2003
21
Does the treatment of primary hyperaldosteronism influence glucose tolerance? (12899664)
2003
22
Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension. (10999827)
2000
23
Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. (10843166)
2000
24
Laparoscopic vs open adrenalectomy for the treatment of primary hyperaldosteronism. (10367872)
1999
25
Bilateral adrenal cortical adenomas in primary hyperaldosteronism. (9763101)
1998
26
Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism. (9380281)
1997
27
Hyperaldosteronism and sudden cardiac death. (8806357)
1996
28
Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism]. (8949378)
1996
29
Primary hyperaldosteronism in pregnancy. A case report. (8728078)
1996
30
Restoration by corticosteroids of the hyperaldosteronism in hyponatraemic rats with panhypopituitarism. (7834996)
1994
31
Chronic sennoside treatment does not cause habituation and secondary hyperaldosteronism in rats. (8234425)
1993
32
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity. (1472060)
1992
33
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
34
Secondary hyperaldosteronism stimulates acidification in rat distal colon. (2174145)
1990
35
Study on clinical and endocrine characteristics of dexamethasone-suppressible hyperaldosteronism compared with those in primary aldosteronism owing to aldosterone-producing adenoma. (2552725)
1989
36
Dexamethasone-suppressible hyperaldosteronism: pathophysiology, clinical aspects, and new insights into the pathogenesis. (3037179)
1987
37
Aldosterone receptors in different types of primary hyperaldosteronism. (3034947)
1987
38
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. (3012766)
1986
39
Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with essential low-renin hypertension and idiopathic hyperaldosteronism. (3882312)
1985
40
Primary adrenal hyperplasia: a new subset of primary hyperaldosteronism. (6707184)
1984
41
Effect of chronic hyperaldosteronism on the electrophysiology of rat distal colon. (6089088)
1984
42
Primary hyperparathyroidism associated with primary hyperaldosteronism. (6349207)
1983
43
Effect of standard oral glucose loading on aldosterone secretion in primary hyperaldosteronism. (6751010)
1982
44
Hyperaldosteronism in ketoacidosis and in poorly controlled non-ketotic diabetes. (6809687)
1982
45
Adrenal glomerulosa function in patients with dexamethasone-suppressible hyperaldosteronism. (7016891)
1981
46
Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism. (6987607)
1980
47
Primary hyperparathyroidism: possible cause of primary hyperaldosteronism in a 60-year-old woman. (6991517)
1980
48
Acute intermittent porphyria associated with inappropriate antidiuretic hormone secretion, hypokalemic alkalosis, and secondary hyperaldosteronism. (472850)
1979
49
Hyperreninemia and secondary hyperaldosteronism in pheochromocytomas. (762609)
1979
50
Differentiation between subtypes of primary hyperaldosteronism by multiple steroid measurement after dexamethasone administration. (713414)
1978

Variations for Hyperaldosteronism

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Expression for genes affiliated with Hyperaldosteronism

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Expression patterns in normal tissues for genes affiliated with Hyperaldosteronism

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Pathways for genes affiliated with Hyperaldosteronism

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Pathways related to Hyperaldosteronism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.5CYP11B2, CYP11B1
2
Show member pathways
estradiol biosynthesis II37
androgen biosynthesis37
estradiol biosynthesis I37
progesterone biosynthesis37
9.5CYP11B2, CYP11B1
39.2POMC, CYP11B1
4
Show member pathways
9.0REN, POMC
5
Show member pathways
8.8AGTR1, REN, CYP11B2
6
Show member pathways
8.7POMC, CYP11B1, CYP11B2
7
Show member pathways
8.7POMC, CYP11B1, CYP11B2
8
Show member pathways
8.7CYP11B2, CYP11B1, POMC

Compounds for genes affiliated with Hyperaldosteronism

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Compounds related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
118-oxocortisol449.8CYP11B1, CYP11B2
218-hydroxycortisol449.8CYP11B1, CYP11B2
319-oic-deoxycorticosterone249.8CYP11B2, CYP11B1
419-Hydroxydeoxycorticosterone249.7CYP11B2, CYP11B1
519-Oxo-deoxycorticosterone249.7CYP11B2, CYP11B1
618-hydroxydeoxycorticosterone449.7CYP11B2, CYP11B1
711b,17a,21-Trihydroxypreg-nenolone249.5CYP11B2, CYP11B1
8aldosterone28 24 1111.4CYP11B2, CYP11B1, AGTR1
9tetrahydroaldosterone449.3CYP11B2, REN
10nitroglycerin44 1110.2KCNJ5, REN, AGTR1
11metoclopramide44 50 1111.2REN, CYP11B2, CYP11B1
12eplerenone44 61 28 1112.2REN, AGTR1, CYP11B2
13benazepril44 50 1111.2CYP11B2, AGTR1, REN
1411b-Hydroxyandrost-4-ene-3,17-dione249.2CYP11B2, CYP11B1
15hydralazine44 50 1111.2CYP11B2, REN, AGTR1
16atenolol44 50 28 24 1113.2CYP11B2, REN, AGTR1
17irbesartan44 28 50 1112.2AGTR1, REN, CYP11B2
18candesartan44 50 28 1112.1AGTR1, REN, CYP11B2
19hydrochlorothiazide44 28 50 24 1113.1CYP11B2, REN, AGTR1
2021-deoxycortisol44 2410.1CYP11B1, POMC, CYP11B2
21ang ii449.1REN, AGTR1, CYP11B2
22etomidate44 1110.1CYP11B1, CYP11B2, POMC
23cortisol28 2410.1POMC, CYP11B1, CYP11B2
24metyrapone44 61 1111.0CYP11B1, POMC, CYP11B2
25methacholine44 50 1111.0REN, KCNJ5, AGTR1
26fludrocortisone44 28 1110.9REN, POMC, CYP11B2
273beta-hydroxysteroid448.9CYP11B2, CYP11B1, POMC
28furosemide44 61 28 50 24 1113.8REN, AGTR1, POMC
29nifedipine44 28 50 1111.8KCNJ5, REN, AGTR1, CYP11B2
30cortisone44 249.6AGTR1, POMC, CYP11B1, CYP11B2
31clonidine44 50 28 1111.6REN, POMC, AGTR1
3218-hydroxycorticosterone44 249.5POMC, REN, CYP11B1, CYP11B2
3311 deoxycortisol448.5CYP11B1, REN, POMC, CYP11B2
34doca448.5CYP11B1, REN, POMC, CYP11B2
3517-hydroxyprogesterone44 249.5REN, POMC, CYP11B1, CYP11B2
36androstenedione44 249.5CYP11B2, CYP11B1, POMC, REN
37corticosterone44 61 2410.5POMC, CYP11B2, REN, CYP11B1
38hydrocortisone44 2 61 1111.4CYP11B2, CYP11B1, POMC, REN
39potassium44 24 1110.4CYP11B2, KCNJ5, REN, AGTR1, CYP11B1
40sodium44 249.3AGTR1, KCNJ5, CYP11B1, CYP11B2, REN
41haloperidol44 50 28 2 1112.0AGTR1, POMC, CYP11B2, KCNJ5, REN
42norepinephrine44 24 1110.0REN, AGTR1, POMC, KCNJ5, CYP11B2
43spironolactone44 61 28 50 1112.0CYP11B1, CYP11B2, POMC, AGTR1, REN
4411beta-hydroxysteroid448.0AGTR1, REN, POMC, CYP11B1, CYP11B2
45acth448.0REN, POMC, CYP11B1, CYP11B2, AGTR1
46estradiol44 24 1110.0POMC, CYP11B1, REN, AGTR1
47forskolin44 50 119.9REN, CYP11B2, AGTR1, CYP11B1, POMC
48dexamethasone44 50 28 1110.9POMC, CYP11B1, REN, AGTR1, CYP11B2
49arginine447.9CYP11B1, CYP11B2, REN, AGTR1, POMC
50glucose447.7AGTR1, CYP11B2, KCNJ5, POMC, REN

GO Terms for genes affiliated with Hyperaldosteronism

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Biological processes related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cortisol biosynthetic processGO:0346519.7CYP11B2, CYP11B1
2aldosterone biosynthetic processGO:0323429.7CYP11B2, CYP11B1
3mineralocorticoid biosynthetic processGO:0067059.7CYP11B1, CYP11B2
4cellular response to potassium ionGO:0358659.6CYP11B2, CYP11B1
5C21-steroid hormone biosynthetic processGO:0067009.6CYP11B1, CYP11B2
6sterol metabolic processGO:0161259.6CYP11B1, CYP11B2
7renin-angiotensin regulation of aldosterone productionGO:0020189.5AGTR1, REN
8cellular response to hormone stimulusGO:0328709.5CYP11B2, CYP11B1
9xenobiotic metabolic processGO:0068059.5CYP11B1, CYP11B2
10steroid metabolic processGO:0082029.4CYP11B1, CYP11B2
11kidney developmentGO:0018229.0AGTR1, REN
12regulation of blood pressureGO:0082178.8REN, POMC, CYP11B1

Molecular functions related to Hyperaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.5CYP11B1, CYP11B2
2steroid 11-beta-monooxygenase activityGO:0045079.2CYP11B1, CYP11B2

Products for genes affiliated with Hyperaldosteronism

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Sources for Hyperaldosteronism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet