MCID: HYP065
MIFTS: 50

Hyperaldosteronism malady

Categories: Genetic diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Hyperaldosteronism

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Aliases & Descriptions for Hyperaldosteronism:

Name: Hyperaldosteronism 11 27 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:446
ICD1030 E26, E26.9
ICD9CM32 255.1, 255.10
MeSH39 D006929
NCIt45 C113213

Summaries for Hyperaldosteronism

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Disease Ontology:11 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards based summary: Hyperaldosteronism is related to hyperaldosteronism, familial, type iii and pheochromocytoma. An important gene associated with Hyperaldosteronism is CYP11B2 (Cytochrome P450 Family 11 Subfamily B Member 2), and among its related pathways are Steroid hormone biosynthesis and superpathway of steroid hormone biosynthesis. The drugs spironolactone pwdr and spironolactone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and kidney, and related mouse phenotypes are growth/size/body region and renal/urinary system.

Wikipedia:71 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

Related Diseases for Hyperaldosteronism

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Diseases in the Hyperaldosteronism family:

Hyperaldosteronism, Familial, Type Ii Hyperaldosteronism, Familial, Type Iii
Hyperaldosteronism, Familial, Type Iv Familial Hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism, familial, type iii33.9NR3C2, REN
2pheochromocytoma29.8MEN1, NPPA, POMC
3myocardial infarction28.8ACE, AGTR1, NPPA, NR3C2, REN
4familial hyperaldosteronism12.3
5hyperaldosteronism, familial, type iv12.1
6hyperaldosteronism, familial, type ii12.1
7conn's syndrome12.1
8aldosteronism, glucocorticoid-remediable12.0
9liddle syndrome11.0
10congenital chloride diarrhea10.8
11hyper-reninism10.8
12liddle syndrome, scnn1b-related10.7
13liddle syndrome, scnn1g-related10.7
14adenoma10.3
15spastic ataxia 310.3CYP11B1, CYP11B2
16smith-mccort dysplasia 210.2NR3C2, REN
17shaken baby syndrome10.2NPPA, REN
18distal monosomy 14q10.2POMC, REN
19glossopharyngeal nerve neoplasm10.2POMC, REN
20endometrial mixed adenocarcinoma10.2POMC, REN
21achromatopsia10.2NPPA, REN
22hypotrichosis simplex10.2ACE, REN
23hyperinsulinemic hypoglycemia, familial, 310.2ACE, REN
24carbohydrate metabolic disorder10.2ACE, REN
25hypothyroidism, congenital nongoitrous, 510.1ACE, REN
26listeriosis10.1ACE, REN
27dientamoebiasis10.1ACE, REN
28bronchiectasis with or without elevated sweat chloride 310.1CYP11B2, NR3C2, REN
29early-onset parkinson disease10.1MEN1, POMC
30congenital nystagmus10.1ACE, REN
31benign peritoneal mesothelioma10.1CYP11B1, CYP11B2, POMC
32hemorrhagic cystitis10.1AGTR1, NR3C2, REN
33preaxial polydactyly of fingers10.1ACE, AGTR1
34mitochondrial complex ii deficiency10.1MEN1, POMC
35hypokalemia10.1
36inferolateral myocardial infarct10.1ACE, NPPA
37dystonia 2510.1NR3C2, REN, SLC12A3
38malignant otitis externa10.1POMC, REN
39cataract 21, multiple types10.1NR3C2, POMC, REN
40aplasia cutis congenita recessive10.0ACE, AGTR1, CYP11B2
41adrenal adenoma10.0
42cascade stomach10.0ACE, AGTR1, REN
43hyperuricemic nephropathy, familial juvenile 210.0ACE, AGTR1, REN
44eye degenerative disease10.0ACE, AGTR1
45flat umbilicus familial10.0ACE, AGTR1, REN
46rapidly progressive glomerulonephritis10.0ACE, NPPA
47cetp-related hyperalphalipoproteinemia10.0ACE, AGTR1
48mixed germ cell-sex cord neoplasm10.0ACE, AGTR1, REN
49cervix small cell carcinoma10.0ACE, AGTR1, REN
50pulmonary neuroendocrine tumor10.0MEN1, POMC

Comorbidity relations with Hyperaldosteronism via Phenotypic Disease Network (PDN):


Hypertension, EssentialHeart Disease
Acute Cystitis

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to hyperaldosteronism

Symptoms & Phenotypes for Hyperaldosteronism

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MGI Mouse Phenotypes related to Hyperaldosteronism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0ACE, AGTR1, CYP11B1, CYP11B2, MEN1, NR3C2
2MP:00053676.9ACE, AGTR1, CYP11B1, CYP11B2, NPPA, NR3C2
3MP:00053856.6ACE, AGTR1, CYP11B1, CYP11B2, KCNJ5, MEN1
4MP:00053766.3ACE, AGTR1, CYP11B1, CYP11B2, CYP17A1, MEN1

Drugs & Therapeutics for Hyperaldosteronism

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Drugs for Hyperaldosteronism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 97)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bromocriptineapproved, investigationalPhase 43125614-03-331101
Synonyms:
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione
(5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman
(5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman
(6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-alpha-(2-methylpropyl)ergotamin-3',6',18-trione
2-Bromo-alpha-ergocryptine
2-Bromo-alpha-ergokryptin
2-Bromo-alpha-ergokryptine
2-Bromoergocryptine Methanesulfonate
2-Bromoergokryptine
2-bromo-α-ergocryptine
2-bromo-α-ergokryptin
2-bromo-α-ergokryptine
22260-51-1 (mesylate (salt))
25614-03-3
AC-13601
AC1L1KXS
AC1Q2716
Alti-Bromocriptine
Apo-Bromocriptine
BIDD:GT0464
BPBio1_001131
BRD-K14496212-001-01-1
Bagren
Biomol-NT_000005
Bromergocryptine
Bromocriptin
Bromocriptina
Bromocriptina [INN-Spanish]
Bromocriptine (USAN/INN)
Bromocriptine Methanesulfonate
Bromocriptine [BAN]
Bromocriptine [USAN:BAN:INN]
 
Bromocriptine methanesulfonate
Bromocriptinum
Bromocriptinum [INN-Latin]
Bromocryptin
Bromocryptine
Bromoergocriptine
Bromoergocryptine
C06856
C32H40BrN5O5
CB-154
CCRIS 3244
CHEBI:3181
CHEMBL493
CID31101
D03165
DB01200
EINECS 247-128-5
Ergocryptine, 2-bromo- (8CI)
Ergoset
LS-64540
Lopac0_000171
MolPort-002-512-064
NCGC00024584-04
NCI60_001365
NSC169774
PDSP2_001500
Parlodel
Parlodel Snaptabs
Prestwick0_000121
Prestwick1_000121
Prestwick2_000121
SPBio_002101
UNII-3A64E3G5ZO
bromocriptine
nchembio873-comp18
2
DopamineapprovedPhase 4383651-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
3
SpironolactoneapprovedPhase 4, Phase 32321952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
4
CaptoprilapprovedPhase 43462571-86-244093
Synonyms:
(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
(2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
(S)-1-(3-Mercapto-2-methyl-1-oxo-propyl)-L-proline
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline
1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)
1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
1j37
3-Mercapto-2-methylpropionyl-proline
62571-86-2
AC-12047
AC1L2B4L
AC1Q29GZ
AC1Q5R48
Acediur
Aceplus
Acepress
Acepril
Alopresin
Apopril
Apopril (TN)
Asisten
BB_NC-2104
BIM-0050290.0001
BPBio1_000063
BRD-K54529596-001-04-0
BSPBio_000057
BSPBio_002976
C 4042
C4042_SIAL
C4042_SIGMA
C8856_SIAL
C9H15NO3S
CHEBI:3380
CHEMBL1560
CHEMBL82
CID44093
CP
CPD0-2067
CPD000059061
Capoten
Capoten (TN)
Captolane
Captopril (JP15/USP/INN)
Captopril [USAN:INN:BAN:JAN]
Captoprilum
Captoprilum [INN-Latin]
Captopryl
Captoril
Captril
Cesplon
D-2-Methyl-3-mercaptopropanoyl-L-proline
D-3-Mercapto-2-methylpropanoyl-L-proline
D-3-Mercapto-2-methylpropionylproline
D00251
DB01197
Dilabar
DivK1c_000208
EINECS 263-607-1
EU-0100302
FT-0082749
Garranil
Garranil (discontinued)
HMS1921C12
HMS2089P19
 
HMS2092I12
HMS500K10
HSDB 6527
Hipertil
Hypertil
IDI1_000208
Isopresol
KBio1_000208
KBio2_001168
KBio2_003736
KBio2_006304
KBio3_002196
KBioGR_001321
KBioSS_001168
L-Captopril
LS-137465
Lopac-C-4042
Lopac0_000302
Lopirin
Lopirin [Switzerland]
Lopril
MCO
MLS000069484
MLS001076488
MolPort-001-794-639
N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
NCGC00015235-01
NCGC00015235-02
NCGC00023654-03
NCGC00023654-04
NCGC00023654-05
NCGC00023654-06
NCGC00023654-07
NCGC00023654-08
NCGC00023654-09
NCGC00023654-10
NINDS_000208
Prestwick3_000019
Prestwick_103
SA 333
SAM002564201
SMP1_000056
SMR000059061
SPBio_001022
SPECTRUM1500682
SQ 14,225
SQ 14225
SQ-14,225
SQ-14,534
SQ-14225
SQ-14534
ST079562
STK802012
Spectrum2_001211
Spectrum3_001388
Spectrum4_000811
Spectrum5_001587
Spectrum_000688
Tenosbon
Tensiomin
Tensobon
Tensoprel
UNII-9G64RSX1XD
UPCMLD-DP003
UPCMLD-DP003:001
X8Z
[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline
captopril
5
Epinephrineapproved, vet_approvedPhase 4, Phase 3, Phase 298551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
6
EplerenoneapprovedPhase 4, Phase 396107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
7
LosartanapprovedPhase 4286114798-26-43961
Synonyms:
(2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
114798-26-4
124750-99-8 (mono-potassium salt)
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol
2-N-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol
2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole
AC1L1H3Q
BIDD:GT0286
BRD-K76205745-001-02-5
BSPBio_002695
C07072
C22H23ClN6O
CHEBI:6541
CHEMBL191
CID3961
CL23623
Cozaar
D08146
DB00678
DUP 89
DuP 89
DuP-753
HMS1922J13
HMS2093E22
Hyzaar
I14-9710
Jsp001094
KBio2_002193
 
KBio2_004761
KBio2_007329
KBio3_001915
KBioGR_001611
KBioSS_002193
L000351
LOSARTAN POTASSIUM
LS-78746
Lacidipine
Lortaan
Losartan
Losartan (INN)
Losartan Potassium
Losartan [INN:BAN]
Losartan monopotassium salt
Losartic
Losartic (TN)
MK-954
MK954
MolPort-003-666-553
NCGC00095125-01
NCGC00095125-02
NCGC00095125-03
Oprea1_644635
SPBio_001893
SPECTRUM1504268
Spectrum2_001677
Spectrum3_000998
Spectrum4_001126
Spectrum5_001466
Spectrum_001713
UNII-JMS50MPO89
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
losartan
losartan potassium
8Bronchodilator AgentsPhase 4, Phase 3, Phase 22965
9Adrenergic alpha-AgonistsPhase 4, Phase 3, Phase 21734
10MineralocorticoidsPhase 4, Phase 3, Phase 2367
11Mineralocorticoid Receptor AntagonistsPhase 4, Phase 3346
12diureticsPhase 4, Phase 31418
13Diuretics, Potassium SparingPhase 4, Phase 31917
14Angiotensin-Converting Enzyme InhibitorsPhase 4724
15Adrenergic AgonistsPhase 4, Phase 3, Phase 23027
16Insulin, Globin ZincPhase 44645
17Adrenergic AgentsPhase 4, Phase 3, Phase 25352
18insulinPhase 44646
19
protease inhibitorsPhase 4, Phase 25471
Synonyms:
 
protease inhibitors
20Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 2, Phase 313168
21HIV Protease InhibitorsPhase 4, Phase 25470
22Antihypertensive AgentsPhase 44207
23Natriuretic AgentsPhase 4, Phase 31697
24RacepinephrinePhase 4, Phase 3, Phase 2985
25HormonesPhase 4, Phase 3, Phase 214415
26Vasoconstrictor AgentsPhase 4, Phase 3, Phase 22122
27Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 223689
28Neurotransmitter AgentsPhase 4, Phase 3, Phase 218340
29Autonomic AgentsPhase 4, Phase 3, Phase 210150
30Epinephryl boratePhase 4, Phase 3, Phase 2985
31MydriaticsPhase 4, Phase 3, Phase 2811
32Antiparkinson AgentsPhase 41574
33Respiratory System AgentsPhase 4, Phase 3, Phase 24997
34Dopamine AgentsPhase 43836
35Dopamine agonistsPhase 4632
36Hormone AntagonistsPhase 4, Phase 2, Phase 313180
37Anti-Asthmatic AgentsPhase 4, Phase 3, Phase 23488
38Adrenergic beta-AgonistsPhase 4, Phase 3, Phase 21714
39Angiotensin II Type 1 Receptor BlockersPhase 41091
40CoagulantsPhase 41500
41AngiotensinogenPhase 41177
42Angiotensin Receptor AntagonistsPhase 41191
43Anti-Arrhythmia AgentsPhase 43093
44Fertility AgentsPhase 4505
45
Angiotensin IIPhase 4117868521-88-0, 11128-99-765143, 172198
Synonyms:
1-8-Angiotensin I
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
Ang II
Angiotensin 2
Angiotensin II (human)
 
Angiotensin II (mouse)
Angiotonin
Asp-arg-val-TYR-ile-his-pro-phe
Human angiotensin II
Hypertensin
Ile(5)-angiotensin II
46KallikreinsPhase 426
47
Hydrocortisoneapproved, vet_approvedPhase 3, Phase 266750-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
48
Lidocaineapproved, vet_approvedPhase 2, Phase 31317137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
49Anti-Inflammatory AgentsPhase 2, Phase 310729
50
glycyrrhetinic acidPhase 2, Phase 39471-53-418526330
Synonyms:
18b-Glycyrrhetic acid
18b-Glycyrrhetinic acid
18b-Glycyrrhtinic acid
3-Glycyrrhetinic acid
3-Hydroxy-11-oxoolean-12-en-29-oate
3-Hydroxy-11-oxoolean-12-en-29-oic acid
3-Hydroxy-11-oxoolean-12-en-29-oic acid (ACD/Name 4.0)
3b-Hydroxy-11-oxo-Olean-12-en-30-oate
3b-Hydroxy-11-oxo-Olean-12-en-30-oic acid
3b-Hydroxy-11-oxoolean-12-en-30-oate
 
3b-Hydroxy-11-oxoolean-12-en-30-oic acid
Biosone
Enoxolone
Glycyrrhetic acid
Glycyrrhetin
Glycyrrhetinate
Glycyrrhetinic acid
Uralenic acid
a-Glycyrrhetinic acid
alpha-Glycyrrhetinic acid
b-Glycyrrhetic acid
beta-Glycyrrhetic acid

Interventional clinical trials:

(show top 50)    (show all 65)
idNameStatusNCT IDPhase
1Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary AldosteronismUnknown statusNCT02127840Phase 4
2The Therapeutic Effect of Bromocriptin in Patients With Primary AldosteronismUnknown statusNCT00451672Phase 4
3Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?Unknown statusNCT00553722Phase 4
4Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary AldosteronismCompletedNCT00155064Phase 4
5Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic AdrenalectomyCompletedNCT01959711Phase 4
6Aldosterone Antagonism and Microvascular FunctionRecruitingNCT01887119Phase 4
7SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.CompletedNCT01096654Phase 3
8The Role of Mineralocorticoid Receptors in Vascular FunctionCompletedNCT00759525Phase 2, Phase 3
9Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial HypertensionCompletedNCT00138944Phase 3
10Effect of Eplerenone on Endothelial Function in Metabolic SyndromeCompletedNCT01319344Phase 3
11Dynamic Hormone Diagnostics in Endocrine DiseaseNot yet recruitingNCT02934399Phase 2, Phase 3
12Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary HyperaldosteronismCompletedNCT00732771Phase 2
13Open-label Study on Treatment of Primary Aldosteronism With EverolimusRecruitingNCT03174171Phase 2
14Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to ChemotherapyActive, not recruitingNCT01867710Phase 2
15Phase II Clinical Trial of Abiraterone Acetate Without Exogenous Glucocorticoids in Men With Castration-resistant Prostate Cancer With Correlative Assessment of Hormone Intermediates.Active, not recruitingNCT02025010Phase 2
16Postoperative Cardiovascular Index Change of Primary AldosteronismUnknown statusNCT00746070
17Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or FibrillationUnknown statusNCT01267747
18Metabolic Syndrome and Insulin Resistance in Primary AldosteronismUnknown statusNCT00173082
19Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.Unknown statusNCT00407784
20Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin ActivityUnknown statusNCT00917345
21D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell ProliferationUnknown statusNCT00173446
22Parathyroid Hormone (PTH) Homeostasis in Bartter SyndromeUnknown statusNCT01021280
23Optimizing Diagnosis Of Primary AldosteronismCompletedNCT02755519
24Study of Myocardial Interstitial Fibrosis in HyperaldosteronismCompletedNCT02938910
25The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary AldosteronismCompletedNCT02216721
26Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and TreatmentCompletedNCT01728493
27Intraoperative Analysis of Cortisol During Adrenal Vein SamplingCompletedNCT01761344
28Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable AldosteronismCompletedNCT00004354
29Natural History of Apparent Mineralocorticoid Excess SyndromeCompletedNCT00474942
30Adrenal Vein Sampling International Study (AVIS Study)CompletedNCT01234220
31Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in ChinaCompletedNCT01459042
32Etiology of Sleep Apnea-related Hyperaldosteronism - BP TreatmentCompletedNCT01897727
33Arterial Stiffness Index as a Predictor of Surgically Correctable Primary AldosteronismCompletedNCT01190501
34Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood PressureCompletedNCT00001176
35Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism HypertensionCompletedNCT00005394
36Cardiovascular Evaluation of Adult PHA 1 PatientsCompletedNCT00646828
37Aldosterone, Microvascular Function and Salt-sensitivityCompletedNCT02068781
38Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIVCompletedNCT01407237
39Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides DiureticsCompletedNCT00276289
40Primary Aldosteronism In Hypertensive Patients in ChinaRecruitingNCT03155139
41Primary Aldosteronism in Western NorwayRecruitingNCT02832388
42Screening for Primary Aldosteronism in a Population of Patients With HypertensionRecruitingNCT03105531
43Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary AldosteronismRecruitingNCT03174847
44Glucose Metabolism in Subjects With Aldosterone-Producing AdenomasRecruitingNCT02362308
45Renal Sympathetic Denervation From The Adventitia on HypertensionRecruitingNCT02642445
46Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study)RecruitingNCT02804321
47Pharmacogenetic Study in Castration-resistant Prostate Cancer Patients Treated With Abiraterone AcetateRecruitingNCT01858441
48Omics Signature in the Diagnosis of HypertensionRecruitingNCT02772315
49The Role of Aldosterone on Augmented Exercise Pressor Reflex in HypertensionRecruitingNCT01996449
50Adrenal Tumors - Pathogenesis and TherapyRecruitingNCT00669266

Search NIH Clinical Center for Hyperaldosteronism

Inferred drug relations via UMLS68/NDF-RT46:

Genetic Tests for Hyperaldosteronism

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Genetic tests related to Hyperaldosteronism:

id Genetic test Affiliating Genes
1 Hyperaldosteronism27

Anatomical Context for Hyperaldosteronism

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MalaCards organs/tissues related to Hyperaldosteronism:

36
Adrenal gland, Testes, Kidney, Pituitary, Heart, Adrenal cortex, Cortex

Publications for Hyperaldosteronism

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Articles related to Hyperaldosteronism:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3. (27793677)
2017
2
Case Report: Nodule Development From Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism. (26580238)
2016
3
Cardiac Structure and Function in Hyperaldosteronism. (27307553)
2016
4
Evaluation of a Recently Established Test for Familial Hyperaldosteronism Type 1. (27923252)
2016
5
Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease. (27442639)
2016
6
Hyperaldosteronism: How to Discriminate Among Different Disease Forms? (27136934)
2016
7
Genetics of primary hyperaldosteronism. (27485459)
2016
8
Primary hyperaldosteronism: a case of unilateral adrenal hyperplasia with contralateral incidentaloma. (27417992)
2016
9
A Woman with Normotensive Primary Hyperaldosteronism. (26997605)
2016
10
Hypertension Cure Following Laparoscopic Adrenalectomy for Hyperaldosteronism is not Universal: Trends Over Two Decades. (27872977)
2016
11
OP.3D.04] ACTIVATED CD4+ AND CD8+ T-CELL SUBPOPULATIONS IN PATIENTS WITH PRIMARY HYPERALDOSTERONISM AND TRUE RESISTANT HYPERTENSION. (27508670)
2016
12
Hyperaldosteronism: Screening and Diagnostic Tests. (26971505)
2016
13
A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome. (27403928)
2016
14
Surgical treatment of posterior nutcracker syndrome presented with hyperaldosteronism. (26892192)
2016
15
Central serous chorioretinopathy in primary hyperaldosteronism. (27393297)
2016
16
Histopathological classification of cross-sectional image negative hyperaldosteronism. (27967304)
2016
17
Interrelationship Between Vitamin D Insufficiency, Calcium Homeostasis, Hyperaldosteronism, and Autoimmunity. (27097975)
2016
18
Hyperaldosteronism induces left atrial systolic and diastolic dysfunction. (27614224)
2016
19
Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. (26962098)
2016
20
KCNK3 Variants Are Associated With Hyperaldosteronism and Hypertension. (27296998)
2016
21
Primary hyperaldosteronism diagnosed with adrenal vein sampling. Characteristics and follow-up after adrenalectomy in a Danish study. (26471096)
2015
22
Resolution of Hyperreninemia, Secondary Hyperaldosteronism, and Hypokalemia With 177Lu-DOTATATE Induction and Maintenance Peptide Receptor Radionuclide Therapy in a Patient With Pancreatic Neuroendocrine Tumor. (26359564)
2015
23
Netherton Syndrome in a Neonate with Possible Growth Hormone Deficiency and Transient Hyperaldosteronism. (26229701)
2015
24
6C.03: A CASE OF SEVERE HYPERALDOSTERONISM CAUSED BY A DE NOVO KCNJ5 MUTATION. (26102935)
2015
25
Pure aldosterone-secreting adrenocortical carcinoma in a patient with refractory primary hyperaldosteronism. (26273475)
2015
26
Galectin-3 Blockade Inhibits Cardiac Inflammation and Fibrosis in Experimental Hyperaldosteronism and Hypertension. (26238446)
2015
27
NCI-H295R cell line as in vitro model of hyperaldosteronism lacks functional KCNJ5 (GIRK4; Kir3.4) channels. (25998841)
2015
28
Iatrogenic myxoedema madness following radioactive iodine ablation for Graves' disease, with a concurrent diagnosis of primary hyperaldosteronism. (26525086)
2015
29
An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis. (26413177)
2015
30
Laparoendoscopic single-site adrenalectomy in patients with primary hyperaldosteronism: A prospective study with long-term follow up. (26626099)
2015
31
An Update on Familial Hyperaldosteronism. (26445452)
2015
32
Diagnostic Performance of Multidetector Computed Tomography in Distinguishing Unilateral From Bilateral Abnormalities in Primary Hyperaldosteronism: Comparison of Multidetector Computed Tomography With Adrenal Vein Sampling. (25594382)
2015
33
Cardiovascular Risk in Primary Hyperaldosteronism. (26575306)
2015
34
Incidental and Intentional Medicine Achieve SimilarA Results in Primary Hyperaldosteronism. (26193964)
2015
35
Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype. (26252618)
2015
36
Different potencies of angiotensin receptor blockers at suppressing adrenal I^-Arrestin1-dependent post-myocardial infarction hyperaldosteronism. (25541135)
2014
37
Hyperaldosteronism and its association with hypotension and azotaemia in canine babesiosis. (25347616)
2014
38
Long-term blood pressure control in patients undergoing adrenalectomy for primary hyperaldosteronism. (25456918)
2014
39
A case of severe hyperaldosteronism caused by a de novo mutation affecting a critical 'salt bridge' Kir3.4 residue. (25322277)
2014
40
Pregnancy normalized familial hyperaldosteronism type I: a novel role for progesterone? (24943290)
2014
41
Refractory hyperaldosteronism in heart failure is associated with plasma renin activity and angiotensinogen polymorphism. (25036270)
2014
42
Discordant genotype-phenotype correlation in familial hyperaldosteronism type III with KCNJ5 gene mutation: a patient report and review of the literature. (24819081)
2014
43
Is adrenal venous sampling mandatory before surgical decision in case of primary hyperaldosteronism? (24481990)
2014
44
Hyperaldosteronism: diagnosis, lateralization, and treatment. (24857581)
2014
45
4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. (25003119)
2014
46
Gender differences in anxiety and depressive symptoms in patients with primary hyperaldosteronism: A cross-sectional study. (22568586)
2014
47
Neuroblastoma accompanied by hyperaldosteronism. (25340174)
2014
48
Outcomes of adrenalectomy in patients with primary hyperaldosteronism - a single centre experience. (25471827)
2014
49
A single-step approach to the diagnosis of primary hyperaldosteronism: filling a true void or burdening the bottleneck of adrenal vein sampling? (24853532)
2014
50
A retrospective study of laparoscopic unilateral adrenalectomy for primary hyperaldosteronism caused by unilateral adrenal hyperplasia. (24488149)
2014

Variations for Hyperaldosteronism

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Expression for genes affiliated with Hyperaldosteronism

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Search GEO for disease gene expression data for Hyperaldosteronism.

Pathways for genes affiliated with Hyperaldosteronism

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GO Terms for genes affiliated with Hyperaldosteronism

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Biological processes related to Hyperaldosteronism according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:003234210.6CYP11B1, CYP11B2
2C21-steroid hormone biosynthetic processGO:000670010.6CYP11B1, CYP11B2
3cellular response to potassium ionGO:003586510.6CYP11B1, CYP11B2
4cortisol biosynthetic processGO:003465110.6CYP11B1, CYP11B2
5angiotensin maturationGO:000200310.4ACE, REN
6beta-amyloid metabolic processGO:005043510.4ACE, REN
7glucocorticoid biosynthetic processGO:000670410.3CYP11B1, CYP17A1
8renin-angiotensin regulation of aldosterone productionGO:000201810.3AGTR1, REN
9regulation of blood vessel diameterGO:009774610.2ACE, AGTR1
10regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.2ACE, AGTR1
11regulation of vasoconstrictionGO:001922910.2ACE, AGTR1
12regulation of vasodilationGO:004231210.2ACE, AGTR1
13steroid biosynthetic processGO:000669410.0CYP11B1, CYP11B2, CYP17A1
14kidney developmentGO:00018229.9ACE, AGTR1, REN
15steroid metabolic processGO:00082029.8CYP11B1, CYP11B2, CYP17A1
16sterol metabolic processGO:00161259.4CYP11B1, CYP11B2, CYP17A1
17regulation of blood pressureGO:00082179.1ACE, CYP11B1, NPPA, POMC, REN

Molecular functions related to Hyperaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1corticosterone 18-monooxygenase activityGO:004778310.6CYP11B1, CYP11B2
2bradykinin receptor bindingGO:003171110.2ACE, AGTR1
3heme bindingGO:002003710.0CYP11B1, CYP11B2, CYP17A1
4steroid 11-beta-monooxygenase activityGO:00045079.9CYP11B1, CYP11B2
5iron ion bindingGO:00055069.9CYP11B1, CYP11B2, CYP17A1
6oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:00167059.3CYP11B1, CYP11B2, CYP17A1

Sources for Hyperaldosteronism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet