MCID: HYP065
MIFTS: 50

Hyperaldosteronism malady

Endocrine category

Summaries for Hyperaldosteronism

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards: Hyperaldosteronism is related to adenoma and adrenal adenoma. An important gene associated with Hyperaldosteronism is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Insulin Processing and Glucuronidation. The drugs spironolactone and spironolactone pwdr and the compounds 18-hydroxycorticosterone and hydralazine have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia:64 Hyperaldosteronism, also aldosteronism, is a medical condition where too much aldosterone is produced by... more...

Aliases & Classifications for Hyperaldosteronism

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

hyperaldosteronism 8 10 45 61


External Ids:

Disease Ontology8 DOID:446
ICD9CM27 255.10, 255.1
MeSH35 D006929
ICD1025 E26, E26.0, E26.9

Related Diseases for Hyperaldosteronism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the familial hyperaldosteronism type 2 family:

hyperaldosteronism hyperaldosteronism, familial, type iii
familial hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.0CYP11B1, NR3C2, MEN1, POMC, KCNJ5, PMS2
2adrenal adenoma30.8POMC, CYP11B1, CYP17A1, CYP21A2, REN, AGTR1
3conn's syndrome30.7NPPA, NR3C2, AGTR1, REN, POMC, CYP11B1
4hypokalemia30.6CYP17A1, REN, CLCNKB, SLC12A3, ACE, CYP11B2
5adrenal carcinoma30.5POMC
6glucocorticoid-remediable aldosteronism30.4NR3C2, CYP11B1, REN, CYP11B2, POMC
7adrenocortical carcinoma30.4CYP11B1, AGTR1, POMC, CYP21A2, CYP17A1, CYP11B2
8pheochromocytoma30.4MEN1, POMC, NPPA, TH
9cushing's syndrome30.0POMC, NR3C2
10vitiligo29.8POMC
11gitelman syndrome29.8CLCNKB, REN, SLC12A3
12nephrosclerosis29.8ACE, NR3C2, AGTR1
13pseudohypoaldosteronism29.8NR3C2, SLC12A3, REN, CYP21A2
14familial hyperaldosteronism10.7
15familial hyperaldosteronism type 210.4
16hyperaldosteronism, familial, type iii10.3
17primary unilateral adrenal hyperplasia10.2
18primary hyperparathyroidism10.2
19n syndrome10.2
20familial hypertension10.2
21cystic fibrosis10.0
22hyperprolactinemia10.0
23polyarteritis nodosa10.0
24polycystic kidney disease10.0
25autosomal dominant disease10.0
26polycystic kidney disease, autosomal dominant10.0
27bod syndrome10.0
28twin twin transfusion syndrome10.0
29sleep apnea10.0
30diabetes insipidus10.0POMC
31fibromuscular dysplasia10.0REN
32mitral valve prolapse10.0AGTR1
33uremia10.0MEN1
34mitral valve disease10.0NPPA
35anuria10.0ACE
36hypothyroidism10.0POMC
37lung cancer10.0POMC
38panic disorder10.0POMC
39hyperparathyroidism10.0MEN1
40hypoglycemia10.0KCNJ5, POMC
41thyroiditis10.0POMC
42glomerulonephritis10.0AGTR1
43pure autonomic failure10.0REN
44pseudohermaphroditism10.0CYP17A1
45ovarian hyperstimulation syndrome10.0REN
46oligohydramnios10.0ACE
47acromegaly10.0MEN1, POMC
48vesicoureteral reflux10.0AGTR1
49cor pulmonale10.0NPPA, AGTR1
50amenorrhea10.0POMC

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to hyperaldosteronism

Clinical Features for Hyperaldosteronism

Drugs & Therapeutics for Hyperaldosteronism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperaldosteronism

Drug clinical trials:

Search ClinicalTrials for Hyperaldosteronism

Search NIH Clinical Center for Hyperaldosteronism

Search CenterWatch for Hyperaldosteronism

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hyperaldosteronism

Anatomical Context for Hyperaldosteronism

Animal Models for Hyperaldosteronism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hyperaldosteronism

Sources:
51PubMed
See all sources

Articles related to Hyperaldosteronism:

(show top 50)    (show all 515)
idTitleAuthorsYear
1
Gender differences in anxiety and depressive symptoms in patients with primary hyperaldosteronism: A cross-sectional study. (22568586)
2014
2
Image-guided ablation of Conn's adenomas in the management of primary hyperaldosteronism. (23218647)
2013
3
Characterization of NCI-H295R cells as an in vitro model of hyperaldosteronism. (23111829)
2013
4
Primary hyperaldosteronism among Chinese hypertensive patients: how are we doing in a local district in Hong Kong. (22665682)
2012
5
A case of myelolipoma with bilateral adrenal hyperaldosteronism cured after unilateral adrenalectomy. (22382563)
2012
6
Prevalence of hyperaldosteronism in primary care patients with resistant hypertension. (22218630)
2012
7
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome. (22323562)
2012
8
Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II. (20927129)
2011
9
Prolonged hyperkalemia following unilateral adrenalectomy for primary hyperaldosteronism. (20420801)
2010
10
Seeking the invisible: I-131 NP-59 SPECT/CT for primary hyperaldosteronism. (19247385)
2009
11
Hyperaldosteronism associated with bilateral macronodular adenomas and a renal mass in the left kidney. (19344018)
2009
12
Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]. (18260994)
2008
13
Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertension. (18584586)
2008
14
Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study. (18539224)
2008
15
G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. (17911395)
2007
16
Prospective evaluation and characteristics of patients with suspected primary hyperaldosteronism. (18072409)
2007
17
Noninvasive adrenal imaging in hyperaldosteronism: is it accurate for correctly identifying patients who should be selected for surgery? (17242897)
2007
18
Increased renal alpha-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. (16449357)
2006
19
Primary hyperaldosteronism associated with hypertensive emergencies. (16783876)
2006
20
Primary hyperaldosteronism: a frequent cause of residual hypertension after successful endovascular treatment of renal artery disease. (16208147)
2005
21
Laparoscopic management of primary hyperaldosteronism: clinical experience with 212 cases. (12478096)
2003
22
Primary hyperaldosteronism. (12373629)
2002
23
Efficacy of an angiotensin II receptor antagonist in managing hyperaldosteronism. (11403366)
2001
24
Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension. (10999827)
2000
25
Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. (10843166)
2000
26
An assessment of diagnostic procedures preparatory to retroperitoneoscopic removal of adenoma in cases of primary hyperaldosteronism. (11228039)
2000
27
Linkage analysis of familial hyperaldosteronism type II--absence of linkage to the gene encoding the angiotensin II receptor type 1. (9506777)
1998
28
Aldosterone synthase gene in patients suffering from hyperaldosteronism. (9888592)
1998
29
Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism. (9380281)
1997
30
Myocardial fibrosis and hyperaldosteronism. (8922933)
1996
31
Renal pathology in patients with primary hyperaldosteronism secondary to an adrenal cortical adenoma. (8804487)
1996
32
Primary hyperaldosteronism]. (7651282)
1995
33
Hybrid gene or hybrid steroids in the detection and screening for familial hyperaldosteronism type I. (8582097)
1995
34
A case of glucocorticoid-suppressible hyperaldosteronism with aldosterone producing adenoma. (3208706)
1988
35
Primary hyperaldosteronism. (3478896)
1987
36
Sodium excretion and atrial natriuretic peptide levels during mineralocorticoid administration. A mechanism for the escape from hyperaldosteronism. (2966064)
1987
37
Primary hyperaldosteronism caused by adrenocortical carcinoma. (3751090)
1986
38
Primary hyperaldosteronism in pregnancy. (3777074)
1986
39
The diagnosis of primary hyperaldosteronism. (6594109)
1984
40
Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by enalapril (MK-421): a new angiotensin-converting enzyme inhibitor. (6306388)
1983
41
Effect of standard oral glucose loading on aldosterone secretion in primary hyperaldosteronism. (6751010)
1982
42
Familial hyperaldosteronism, not suppressed by dexamethasone. (7119083)
1982
43
Genetic and pathophysiologic studies of a new kindred with glucocorticoid-suppressible hyperaldosteronism manifest in three generations. (7026592)
1981
44
The myth of idiopathic hyperaldosteronism. (6113452)
1981
45
Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism. (6987607)
1980
46
Hyperaldosteronism in the sodium depleted rat: effect of a low sodium diet or diuretic treatment on steroid output by the superfused adrenal zona glomerulosa. (543403)
1979
47
Hyperreninemia and hyperaldosteronism in sickle cell anemia. (448560)
1979
48
Hyperaldosteronism with coexistence of adrenal cortical adenoma and pheochromocytoma. (288840)
1979
49
Hyperaldosteronism (Conn's disease) presenting as depression. (468762)
1979
50
Primary hyperaldosteronism due to left adrenal adenoma. Report of a case. (13898539)
1962

Genetic Variations for Hyperaldosteronism

Expression for genes affiliated with Hyperaldosteronism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperaldosteronism

Search GEO for disease gene expression data for Hyperaldosteronism.

Pathways for genes affiliated with Hyperaldosteronism

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB
See all sources

Compounds for genes affiliated with Hyperaldosteronism

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone45 2411.4CYP11B2, POMC, REN, CYP11B1
2hydralazine45 50 1112.4CYP11B2
3pcb 1264510.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
4deoxycorticosterone29 2411.3CYP21A2, CYP11B2, CYP11B1, NR3C2
521-deoxycortisol45 2411.3CYP21A2, CYP17A1, CYP11B2, CYP11B1, POMC
6metoclopramide45 1111.2CYP11B1, CYP11B2, NPPA, CYP17A1, REN
7cortisol29 2411.2CYP11B1, POMC, NR3C2, CYP11B2, CYP21A2
8benazepril45 1111.2ACE, REN, AGTR1, NPPA
9cilazapril45 1111.2NPPA, AGTR1, REN, ACE
10aldosterone29 11 2412.2CYP17A1, CYP11B2, CYP11B1, AGTR1, NR3C2
11trandolapril45 1111.2ACE, AGTR1, NPPA, REN
12eplerenone45 60 29 1113.2AGTR1, ACE, REN, NR3C2, CYP11B2
13metyrapone60 45 1112.2POMC, CYP21A2, CYP11B2, CYP11B1, NR3C2
14fosinopril45 1111.2ACE, REN, AGTR1, NPPA
1517-hydroxyprogesterone45 2411.2CYP21A2, CYP11B1, CYP17A1, POMC, REN, CYP11B2
16thiazide4510.1NR3C2, AGTR1, REN, SLC12A3, ACE
17cortisone45 2411.1AGTR1, CYP11B2, CYP11B1, POMC, CYP21A2, NR3C2
18fludrocortisone45 29 1112.1CYP21A2, CYP11B2, POMC, REN, NR3C2, NPPA
19felodipine45 29 1112.1AGTR1, NR3C2, REN, NPPA, ACE
20norepinephrine45 11 2412.1TH, CYP21A2, CYP11B2, POMC, KCNJ5, NR3C2
21nitroglycerin45 1111.1ACE, REN, AGTR1, NPPA, KCNJ5
223beta-hydroxysteroid4510.1NR3C2, CYP11B1, CYP11B2, CYP17A1, CYP21A2, POMC
23hydrochlorothiazide45 50 29 11 2414.1NR3C2, REN, ACE, SLC12A3, AGTR1, CYP11B2
24quinapril45 1111.1REN, ACE, AGTR1, NPPA
25androstenedione45 2411.1REN, CYP21A2, CYP17A1, CYP11B2, POMC, CYP11B1
26furosemide45 50 60 29 11 2415.1POMC, REN, NPPA, AGTR1, ACE, SLC12A3
27ang ii4510.1AGTR1, CYP11B2, REN, ACE, NR3C2, NPPA
28doca4510.0NR3C2, REN, CYP21A2, CYP17A1, CYP11B2, CYP11B1
2911 deoxycortisol4510.0REN, CYP21A2, CYP17A1, CYP11B2, CYP11B1, POMC
30lisinopril45 11 2412.0AGTR1, ACE, NPPA, REN
31losartan45 50 29 1113.0ACE, NPPA, NR3C2, AGTR1, CYP11B2, REN
32oxygen45 2411.0KCNJ5, CYP11B2, CYP11B1, CYP17A1, CYP21A2, NR3C2
33nifedipine45 50 29 1113.0CYP17A1, KCNJ5, ACE, REN, NPPA, AGTR1
34captopril45 29 50 60 1113.9NR3C2, REN, ACE, AGTR1, NPPA
35hydrocortisone45 2 60 1112.9NR3C2, POMC, CYP11B1, CYP11B2, CYP21A2, REN
3611beta-hydroxysteroid459.9CYP21A2, AGTR1, NR3C2, POMC, CYP11B1, CYP11B2
37catecholamine459.9REN, CYP21A2, TH, POMC, NR3C2, NPPA
38haloperidol45 29 2 50 1113.9KCNJ5, NR3C2, POMC, CYP11B2, REN, NPPA
39corticosterone45 60 2411.9CYP21A2, CYP17A1, REN, POMC, NR3C2, CYP11B2
40forskolin45 50 1111.9CYP11B2, POMC, CYP11B1, CYP17A1, REN, TH
41ramipril45 1110.8AGTR1, ACE, REN, NPPA
42acth459.7NPPA, REN, AGTR1, POMC, CYP11B2, CYP11B1
43spironolactone50 45 60 29 1113.7AGTR1, POMC, CYP11B1, CYP11B2, CYP21A2, REN
44atenolol45 29 50 11 2413.7ACE, REN, CYP11B2, AGTR1
45testosterone45 60 11 2412.6CYP11B2, CYP21A2, TH, KCNJ5, POMC, NR3C2
46potassium45 11 2411.5REN, KCNJ5, NPPA, NR3C2, AGTR1, CYP11B1
47sodium45 2410.5KCNJ5, NPPA, NR3C2, AGTR1, CYP11B1, REN
48dexamethasone45 50 29 1112.4CYP17A1, CYP21A2, REN, TH, CYP11B1, POMC
49arginine459.3NR3C2, AGTR1, NPPA, REN, CYP11B1, CYP11B2
50calcium45 50 11 2412.0ACE, CLCNKB, REN, SLC12A3, KCNJ5, NPPA

GO Terms for genes affiliated with Hyperaldosteronism

Sources:
16Gene Ontology
See all sources

Biological processes related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cortisol biosynthetic processGO:03465110.5CYP11B1, CYP11B2
2aldosterone biosynthetic processGO:03234210.5CYP11B1, CYP11B2
3renin-angiotensin regulation of aldosterone productionGO:00201810.5REN, AGTR1
4cellular response to potassium ionGO:03586510.5CYP11B1, CYP11B2
5mineralocorticoid biosynthetic processGO:00670510.4CYP21A2, CYP11B2, CYP11B1
6glucocorticoid biosynthetic processGO:00670410.4CYP11B1, CYP17A1, CYP21A2
7C21-steroid hormone biosynthetic processGO:00670010.4CYP11B1, CYP11B2
8phthalate metabolic processGO:01896310.4CYP17A1, TH
9regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3AGTR1, ACE
10sterol metabolic processGO:01612510.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
11steroid metabolic processGO:00820210.3CYP21A2, CYP17A1, CYP11B2, CYP11B1
12response to herbicideGO:00963510.3TH, CYP17A1
13xenobiotic metabolic processGO:00680510.2CYP11B1, CYP11B2, CYP17A1, CYP21A2
14response to nutrient levelsGO:03166710.2TH, CYP17A1
15regulation of blood pressureGO:00821710.1NPPA, POMC, CYP11B1, REN, ACE
16regulation of vasodilationGO:04231210.1AGTR1, ACE
17kidney developmentGO:00182210.1ACE, REN, AGTR1
18angiotensin maturationGO:0020039.9ACE, REN

Molecular functions related to Hyperaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:00450710.3CYP11B2, CYP11B1
2bradykinin receptor bindingGO:03171110.2ACE, AGTR1
3electron carrier activityGO:00905510.0CYP21A2, CYP17A1, CYP11B2, CYP11B1
4heme bindingGO:0200379.9CYP11B1, CYP11B2, CYP17A1, CYP21A2
5iron ion bindingGO:0055069.7CYP11B1, CYP11B2, CYP17A1, CYP21A2

Products for genes affiliated with Hyperaldosteronism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperaldosteronism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet