Hyperaldosteronism malady

Wikipedia: Hyperaldosteronism, also aldosteronism, is a medical condition where too much aldosterone is produced by...⁴⁴ more...

MalaCards: Hyperaldosteronism is related to familial hyperaldosteronism and hypertension. An important gene associated with Hyperaldosteronism is FHA2 (Hyperaldosteronism, familial, type II), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Renin-angiotensin system. The drugs spironolactone and spironolactone pwdr [va product] and the compounds atenolol and 21-deoxycortisol have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and endothelial, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

hyperaldosteronism 6 7 8 32 43

Diseases related to hyperaldosteronism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 291)

id	Related Disease	Score	Top Affiliating Genes
1	familial hyperaldosteronism	33.5	REN, RBAK, KCNJ5, FHA2, GNA12, CYP11B2
2	hypertension	32.4	REN, CYP11B2, ACE, AGT, AGTR1
3	glucocorticoid-remediable aldosteronism	31.9	KCNJ5, CYP11B2, CYP11B1
4	conn's syndrome	30.8	REN, CYP11B2, NR3C2, AGTR1
5	malignant hypertension	28.1	REN, ACE
6	low renin hypertension	28.0	REN, HSD11B2, CYP11B2
7	hyporeninemic hypoaldosteronism	27.6	REN, INS, ACE
8	hyperprolactinemia	26.9	INS, LSL, TH, POMC
9	adrenal adenoma	26.2	REN, MEN1, APC, CYP11B1, CYP17A1, CYP21A2
10	pheochromocytoma	26.2	REN, INSR, MEN1, CYP21A2, ACE, TH
11	bartter disease	25.8	REN, KCNJ5, MEN1, CYP11B2, CYP11B1, CYP21A2
12	adrenal hyperplasia	24.4	REN, INS, HTR4, HSD11B2, CYP11B2, CYP11B1
13	hypokalemia	24.3	REN, CLCNKB, KCNJ1, KCNJ5, INS, HSD11B2
14	essential hypertension	23.9	REN, CLCNKB, KCNJ1, KCNJ5, SCNN1G, INS
15	aldosteronism	23.8	REN, CLCNKB, KCNJ1, KCNK9, KCNJ5, SCNN1G
16	twinning	22.9	REN, INS, INSR, MEN1, APC, HSD11B2
17	adenoma	20.9	REN, KCNJ5, INS, INSR, MEN1, GRM3
18	11-beta-hydroxylase-deficient congenital adrenal hyperplasia	13.7	CYP11B2, CYP11B1
19	adjustment disorder	13.6	TH, POMC
20	17-alpha-hydroxylase deficiency	13.6	REN, CYP11B2, CYP17A1
21	17-alpha-hydroxylase/17,20-lyase deficiency	13.6	CYP17A1, POMC
22	late-onset congenital adrenal hyperplasia	13.6	CYP21A2, POMC
23	bartter syndrome, type 2	13.6	REN, KCNJ1
24	glucocorticoid deficiency	13.6	REN, CYP17A1, POMC
25	hypertension with brachydactyly	13.6	REN, NR3C2
26	pure autonomic failure	13.5	REN, TH
27	11-beta-hydroxylase deficiency	13.5	REN, CYP11B2, CYP11B1, CYP21A2
28	renal hypertension	13.5	REN, ACE, SLC12A3
29	3-beta-hydroxysteroid dehydrogenase deficiency	13.5	CYP17A1, CYP21A2
30	autosomal dominant pseudohypoaldosteronism type 1	13.5	SCNN1G, NR3C2
31	pseudohypoaldosteronism type ii	13.5	REN, KCNJ1, SLC12A3
32	antley-bixler syndrome	13.5	CYP17A1, CYP21A2, POMC
33	orthostatic hypotension	13.5	REN, ACE, NPPA
34	hepatorenal syndrome	13.5	REN, ACE, NPPA
35	cerebral aneurysms	13.5	REN, AGTR1, NPPA
36	autoimmune polyendocrine syndrome type 1	13.4	CYP17A1, CYP21A2, TH
37	brugada syndrome	13.4	KCNJ5, NR3C2, ACE
38	renovascular hypertension	13.4	REN, ACE, AGTR1, NPPA
39	chronic rapidly progressive glomerulonephritis	13.4	CYP11B2, ACE, AGTR1, NPPA
40	apparent mineralocorticoid excess syndrome	13.4	REN, HSD11B2, NR3C2
41	bartter syndrome antenatal type 2	13.4	REN, KCNJ1, SLC12A1
42	cor pulmonale	13.4	REN, ACE, AGTR1, NPPA
43	cushing's syndrome	13.4	HSD11B2, NR3C2, POMC
44	21-hydroxylase deficiency	13.3	CYP11B2, CYP11B1, CYP17A1, CYP21A2, POMC
45	gynecomastia	13.3	CYP17A1, CYP21A2, NR3C2, POMC
46	pseudohermaphroditism	13.3	CYP17A1, CYP21A2, POMC
47	dent disease	13.3	REN, CLCNKB, SLC12A1, SLC12A3
48	paraganglioma	13.3	REN, MEN1, TH, POMC
49	nephrogenic diabetes insipidus	13.3	REN, AGTR1, NPPA, SLC12A1
50	glucocorticoid resistance	13.2	REN, HSD11B2, NR3C2, POMC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 spironolactone, spironolactone pwdr [va product]

MalaCards organs/tissues related to hyperaldosteronism:

²²

MGI Mouse Phenotypes related to hyperaldosteronism:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.2	PMS2, CYP11B1, CYP11B2, GNRHR, GPRC6A, MEN1
2	hematopoietic system phenotype	MP:0005397	8.7	ADAR, SLC12A1, PMS2, GNA12, APC, KCNJ1
3	reproductive system phenotype	MP:0005389	7.9	SLC12A1, PMS2, AGT, CYP11B1, GNRHR, GPRC6A
4	muscle phenotype	MP:0005369	7.4	AGT, CYP11B2, HSD11B2, GNA12, APC, MEN1
5	adipose tissue phenotype	MP:0005375	6.9	POMC, AGT, ACE, CYP11B1, HTR4, GPR37
6	liver/biliary system phenotype	MP:0005370	6.8	ADAR, TH, AGT, ACE, CYP11B1, GPRC6A
7	normal phenotype	MP:0002873	6.7	GNA12, GNRHR, HSD11B2, TH, GPR37, APC
8	immune system phenotype	MP:0005387	6.5	AGTR1, POMC, PMS2, SLC12A1, ADAR, AGT
9	growth/size phenotype	MP:0005378	5.9	NR3C2, ACE, AGT, AGTR1, TH, SLC12A1
10	renal/urinary system phenotype	MP:0005367	5.3	SLC12A3, APC, INSR, INS, SCNN1G, KCNJ1
11	behavior/neurological phenotype	MP:0005386	5.0	CYP11B2, CYP17A1, NR3C2, ACE, AGT, TH
12	cardiovascular system phenotype	MP:0005385	4.8	AGTR1, AGT, ACE, NR3C2, TH, POMC
13	mortality/aging	MP:0010768	4.7	NR3C2, ACE, AGT, AGTR1, TH, POMC
14	homeostasis/metabolism phenotype	MP:0005376	3.2	ADAR, SLC12A3, SLC12A1, NPPA, PMS2, POMC

Articles related to hyperaldosteronism:

(show top 50)    (show all 82)

id	Title	Authors	Year	Affiliating Genes
1	KCNJ5 Mutations in European Families With Nonglucocorticoid Remediable Familial Hyperaldosteronism. (22203740)	Mulatero P.... Reincke M.	2012	KCNJ5
2	Mutations in KCNJ5 gene cause hyperaldosteronism. (21659651)	Zennaro M.C.... Jeunemaitre X.	2011	KCNJ5
3	Feline primary hyperaldosteronism. (20219494)	Schulman R.L.	2010	REN
4	Hyperaldosteronism in pregnancy. (19171690)	Escher G.	2009	CYP11B1, NR3C2, CYP11B2
5	Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by a de novo mutation (19030657)	Stehr C.B.... Fardella C.E.	2008	CYP11B1
6	G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. (17911395)	Ye P.... Rainey W.E.	2007	GRM3, HTR4, GNRHR
7	Maternal pseudo primary hyperaldosteronism in twin-to-twin transfusion syndrome. (17233862)	Gussi I.L.... Ville Y.	2007	NPPA
8	High frequency of primary hyperaldosteronism among hypertensive patients from a primary care area in Sweden. (16923624)	Westerdahl C.... Valdemarsson S.	2006	REN
9	No evidence for coding region mutations in the retinoblastoma-associated Kruppel-associated box protein gene (RBaK) causing familial hyperaldosteronism type II. (17121540)	So A.... Stowasser M.	2006	RBAK
10	Modern pharmacological aspects of hyperaldosteronism therapy (16823578)	Quinkler M.... Reincke M.	2006	NR3C2
11	Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. (15745200)	Hood S.... Brown M.	2005	ACE, REN
12	Comparison of active renin concentration and plasma renin activity for the diagnosis of primary hyperaldosteronism in patients with an adrenal mass. (15080782)	Unger N.... Petersenn S.	2004	REN
13	A case of insulin edema with inappropriate hyperaldosteronism. (15762045)	Kalambokis G.... Tsianos E.V.	2004	REN, INS
14	Genomic structure of the human gene for protein kinase A regulatory subunit R1-beta (PRKAR1B) on 7p22: no evidence for mutations in familial hyperaldosteronism type II in a large affected kindred. (15579186)	Elphinstone M.S.... Stowasser M.	2004	CYP11B1
15	Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism. (15173035)	Nishizaka M.K.... Calhoun D.A.	2004	REN
16	Rapid screening test for primary hyperaldosteronism: ratio of plasma aldosterone to renin concentration determined by fully automated chemiluminescence immunoassays. (15247156)	Perschel F.H.... Diederich S.	2004	REN
17	Primary hyperaldosteronism (12951726)	van den Meiracker A.H.... Deinum J.	2003	POMC
18	Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity. (11840228)	HaluzA-k M.... Skrha J.	2002	LSL
19	New genetic insights in familial hyperaldosteronism. (12381543)	Jackson R.V.... Stratakis C.	2002	CYP11B1, CYP11B2
20	Familial hyperaldosteronism. (11595502)	Stowasser M.... Gordon R.D.	2001	CYP11B1, CYP11B2
21	A chimeric CYP11B1/CYP11B2 gene in glucocorticoid-insuppressible familial hyperaldosteronism. (11453962)	Ise T.... Kobayashi K.	2001	CYP11B1, CYP11B2
22	CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism. (10720580)	Mulatero P.... Veglio F.	2000	CYP11B2
23	Insulin action in primary hyperaldosteronism before and after surgical or pharmacological treatment. (10768828)	Sindelka G.... Skrha J.	2000	INS
24	A case of unilateral adrenal hyperplasia: the diagnos tic dilemma of hyperaldosteronism. (11421533)	Haenel L.C.... Hermayer K.L.	2000	REN
25	Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension. (10999827)	Stowasser M.... Gordon R.D.	2000	POMC
26	Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. (10843166)	Fardella C.E.... Montero J.	2000	CYP11B1, CYP11B2
27	Severity of hypertension in familial hyperaldosteronism type I: relationship to gender and degree of biochemical disturbance. (10852446)	Stowasser M.... Gordon R.D.	2000	CYP11B1
28	A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22). (11073536)	Lafferty A.R.... Stratakis C.A.	2000	CYP11B1, CYP11B2, FHA2
29	Familial hyperaldosteronism. (11004715)	Torpy D.J.... Chrousos G.P.	2000	CYP11B1, CYP11B2
30	Impaired insulin action in primary hyperaldosteronism. (10984090)	WidimskA1 J.... Skrha J.	2000	INSR
31	Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism. (10323392)	Takeda Y.... Mabuchi H.	1999	CYP11B2
32	Primary hyperaldosteronism--12 clinical cases (10536470)	Telles E.C.... Vagueiro C.	1999	REN
33	Linkage analysis of familial hyperaldosteronism type II--absence of linkage to the gene encoding the angiotensin II receptor type 1. (9506777)	Torpy D.J.... Gordon R.D.	1998	AGTR1
34	Aldosterone synthase gene in patients suffering from hyperaldosteronism. (9888592)	Hampf M.... Bernhardt R.	1998	CYP11B2
35	Primary hyperaldosteronism. (15251493)	Laurel M.T.... Kabadi U.M.	1997	REN
36	Evidence for persistent dysfunction of wild-type aldosterone synthase gene in glucocorticoid-treated familial hyperaldosteronism type I. (9488230)	Stowasser M.... Gordon R.D.	1997	CYP11B1
37	Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism. (9380281)	Lefebvre H.... Kuhn J.M.	1997	APC
38	Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism (8949378)	Chamontin B.... Salvador M.	1996	REN
39	Mutation of cytochrome P-45017 alpha gene (CYP17) in a Japanese patient previously reported as having glucocorticoid-responsive hyperaldosteronism: with a review of Japanese patients with mutations of CYP17. (8855840)	Miura K.... Shizuta Y.	1996	CYP17A1
40	Primary hyperaldosteronism (7651282)	Opocher G.... Mantero F.	1995	REN
41	Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree. (7593610)	Pascoe L.... Corvol P.	1995	CYP11B1
42	A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension. (7864844)	Jonsson J.R.... Gordon R.D.	1995	CYP11B1
43	Plasma immunoreactive endothelin-1 in primary hyperaldosteronism. (7917156)	Veglio F.... Chiandussi L.	1994	REN, NPPA
44	Diagnosis and treatment of primary hyperaldosteronism. (7978702)	Blumenfeld J.D.... Laragh J.H.	1994	NPPA
45	Primary hyperaldosteronism--4 clinical cases (8117459)	Nuno L.... Afonso J.S.	1993	REN
46	Renin-aldosterone response to dexamethasone in glucocorticoid-suppressible hyperaldosteronism is altered by coexistent renal artery stenosis. (8396580)	Stowasser M.... Tunny T.J.	1993	REN
47	Hyperreninemia and secondary hyperaldosteronism in a patient with pheochromocytoma and von Hippel-Lindau disease. (1436350)	Lenz T.... Schulte K.L.	1992	REN
48	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. (1518866)	Pascoe L.... White P.C.	1992	POMC, CYP11B1, CYP11B2
49	The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity. (1472060)	Miyahara K.... Shizuta Y.	1992	CYP11B2
50	Decreased insulin receptor number and affinity in subcutaneous adipose tissue in a patient with primary hyperaldosteronism (1891638)	Carranza M.C.... Calle C.	1991	INSR

Genes related to hyperaldosteronism according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	FHA2	Hyperaldosteronism, familial, type II	11.1	Aliases & Descriptions, Publications
2	CYP11B1	cytochrome P450, family 11, subfamily B, polypeptide 1	11.0	Publications
3	CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	11.0	Publications
4	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
5	REN	renin	11.0	Publications
6	POMC	proopiomelanocortin	11.0	Publications
7	AGTR1	angiotensin II receptor, type 1	11.0	Publications
8	RBAK	RB-associated KRAB zinc finger	11.0	Publications
9	CLCNKB	chloride channel, voltage-sensitive Kb	11.0
10	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Publications
11	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0
12	MEN1	multiple endocrine neoplasia I	11.0
13	GNA12	guanine nucleotide binding protein (G protein) alpha 12	11.0	Publications
14	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
15	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.0	Publications
16	NPPA	natriuretic peptide A	11.0	Publications
17	TH	tyrosine hydroxylase	11.0	Publications
18	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0
19	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
20	GPR37	G protein-coupled receptor 37 (endothelin receptor type B-like)	11.0	Publications
21	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	11.0
22	GPRC6A	G protein-coupled receptor, family C, group 6, member A	11.0	Publications
23	GNRHR	gonadotropin-releasing hormone receptor	11.0	Publications
24	SCNN1G	sodium channel, non-voltage-gated 1, gamma subunit	11.0
25	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0
26	ADAR	adenosine deaminase, RNA-specific	11.0
27	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0
28	KCNK9	potassium channel, subfamily K, member 9	11.0
29	HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	11.0	Publications
30	GRM3	glutamate receptor, metabotropic 3	11.0	Publications
31	LSL	Leptin, serum levels of	11.0	Publications
32	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
33	INSR	insulin receptor	11.0	Publications
34	APC	adenomatous polyposis coli	11.0	Publications
35	INS	insulin	11.0	Publications

Pathways related to hyperaldosteronism according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.3	NR3C2, AGTR1
2	Renin-angiotensin system20	9.5	AGTR1, AGT, ACE, REN
3	Steroid hormone biosynthesis20	9.4	CYP21A2, CYP17A1, CYP11B1, CYP11B2, HSD11B2
4	Aldosterone Signaling in Epithelial Cells36	9.4	KCNK9, SCNN1G, SLC12A1, SLC12A3
5	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.3	AGTR1, AGT, ACE, NR3C2, CYP11B2, REN
6	Aldosterone-regulated sodium reabsorption20	9.3	KCNJ1, INS, HSD11B2, NR3C2
7	IRS activation38	9.0	INS, INSR

Compounds related to hyperaldosteronism according to GeneDecks:

(show top 50)    (show all 202)

id	Compound	Score	Top Affiliating Genes
1	atenolol32 9 18 9	13.4	CYP11B2
2	21-deoxycortisol32 18	11.1	CYP11B1, CYP21A2, CYP17A1, CYP11B2, POMC
3	18-hydroxycorticosterone32 18	11.0	CYP11B1, REN, POMC, CYP11B2
4	eplerenone32 42 9 9	13.0	CYP11B2, REN, NR3C2, AGTR1, ACE
5	17-hydroxyprogesterone32 18	10.9	POMC, REN, CYP21A2, CYP17A1, CYP11B1, CYP11B2
6	11 deoxycortisol32	9.8	CYP11B1, NR3C2, CYP17A1, CYP21A2, POMC, CYP11B2
7	Aldosterone9 18 9	11.8	CYP11B2, CYP11B1, CYP17A1, NR3C2, AGTR1
8	metoclopramide32 9 9	11.7	REN, CYP17A1, CYP11B1, CYP11B2, NPPA, HTR4
9	benazepril32 9 9	11.6	ACE, REN, AGTR1, NPPA, AGT
10	3beta-hydroxysteroid32	9.6	POMC, NR3C2, HSD11B2, CYP11B2, CYP11B1, CYP17A1
11	doca32	9.5	POMC, NR3C2, CYP21A2, CYP11B1, CYP11B2, HSD11B2
12	fludrocortisone32 9 9	11.5	POMC, NPPA, LSL, NR3C2, REN, CYP21A2
13	glucose32	9.5	GRM3, APC, KCNJ5
14	lisinopril32 9 18 9	12.4	REN, ACE, AGT, AGTR1, NPPA
15	11beta-hydroxysteroid32	9.4	CYP17A1, CYP21A2, NR3C2, AGTR1, POMC, CYP11B1
16	ang ii32	9.3	NPPA, AGT, ACE, NR3C2, CYP11B2, REN
17	furosemide32 42 34 9 18 9	14.3	ACE, NPPA, AGTR1, HSD11B2, SLC12A1, REN
18	thiazide32	9.3	ACE, INS, AGTR1, SLC12A1, SLC12A3, NR3C2
19	olmesartan32 9 9	11.2	AGT, AGTR1, ACE, INS, REN
20	losartan32 34 9 9	12.2	REN, AGTR1, CYP11B2, NR3C2, ACE, AGT
21	ramipril32 9 9	11.2	INS, REN, AGTR1, NPPA, ACE
22	aliskiren32 9 9	11.2	REN, ACE, AGT, AGTR1
23	nifedipine32 9 9	11.2	CYP11B2, NPPA, KCNJ5, REN, AGT, CYP17A1
24	spironolactone32 42 34 9 9	13.2	NPPA, AGTR1, REN, HSD11B2, CYP11B2, CYP11B1
25	cortisone32 18	10.2	INS, HSD11B2, CYP11B2, CYP11B1, CYP21A2, NR3C2
26	hydrochlorothiazide32 34 9 18 9	13.1	HSD11B2, CYP11B2, NR3C2, ACE, AGT, AGTR1
27	moxonidine32	9.1	INS, INSR, REN, ACE, NPPA
28	corticosterone32 18	9.9	HSD11B2, CYP11B2, CYP11B1, NR3C2, TH, CYP17A1
29	estradiol32 9 18 9	11.8	HSD11B2, POMC, CYP17A1, REN, AGTR1, CYP21A2
30	dhea32	8.7	HSD11B2, CYP11B2, CYP17A1, POMC, LSL, NR3C2
31	haloperidol32 34 9 9	11.7	NPPA, NR3C2, REN, KCNJ5, CYP11B2, LSL
32	androstenedione32 18	9.7	CYP21A2, HSD11B2, CYP11B2, CYP11B1, CYP17A1, POMC
33	creatinine32	8.6	REN, HSD11B2, POMC, AGTR1, AGT, ACE
34	hydrocortisone32 9 9	10.1	HSD11B2, CYP11B1, CYP21A2, NR3C2, LSL, POMC
35	calcium32 9 18 9	10.9	CYP11B1, AGT, REN, CLCNKB, KCNK9, MEN1
36	testosterone32 9 18 9	10.8	INSR, GNRHR, CYP11B2, CYP11B1, CYP17A1, KCNJ5
37	oxygen32 18	8.6	TH, CYP11B2, GPRC6A, KCNJ5, CYP17A1, CYP21A2
38	dopamine32 9 18 9	10.6	GNRHR, AGT, NR3C2, NPPA, GPRC6A, APC
39	cholesterol32 9 18 9	10.6	ACE, AGT, AGTR1, LSL, CYP17A1, REN
40	potassium32 9 18 9	10.6	KCNJ1, CLCNKB, REN, KCNK9, AGTR1, AGT
41	forskolin32 42 9 9	10.3	POMC, NPPA, SLC12A1, REN, APC, GNRHR
42	sodium32 18	8.3	SLC12A1, NPPA, AGTR1, AGT, NR3C2, CYP11B1
43	glutamate32	7.3	KCNJ5, INS, INSR, GRM3, HTR4, CYP21A2
44	alanine32	7.2	AGTR1, KCNJ1, KCNK9, INSR, LSL, GNRHR
45	dexamethasone32 42 34 9 9	11.0	INSR, INS, TH, AGTR1, AGT, LSL
46	epinephrine32 9 18 9	9.9	REN, NPPA, AGTR1, AGT, POMC, LSL
47	acth32	6.5	AGTR1, AGT, LSL, NR3C2, HTR4, HSD11B2
48	norepinephrine32 9 18 9	9.4	REN, KCNJ5, INS, APC, GPRC6A, HSD11B2
49	estrogen32	6.4	POMC, INSR, MEN1, NPPA, TH, AGTR1
50	arginine32	5.7	ADAR, NPPA, POMC, AGTR1, AGT, LSL

Cellular components related to hyperaldosteronism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	7.9	CLCNKB, SCNN1G, INSR, GRM3, GPR37, HTR4

Biological processes related to hyperaldosteronism according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of blood volume by renal aldosterone	GO:002017	10.4	HSD11B2
2	cortisol biosynthetic process	GO:034651	10.4	CYP11B1, CYP11B2
3	mineralocorticoid biosynthetic process	GO:006705	10.4	CYP11B2, CYP11B1, CYP21A2
4	aldosterone biosynthetic process	GO:032342	10.3	CYP11B1, CYP11B2
5	cellular response to potassium ion	GO:035865	10.1	CYP11B2, CYP11B1
6	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	10.1	AGTR1, ACE
7	steroid metabolic process	GO:008202	10.1	CYP21A2, CYP17A1, CYP11B1, CYP11B2
8	regulation of blood pressure	GO:008217	10.0	NPPA, POMC, ACE, CYP11B1, REN
9	positive regulation of NAD(P)H oxidase activity	GO:033864	10.0	AGT, AGTR1
10	renin-angiotensin regulation of aldosterone production	GO:002018	10.0	REN, AGT, AGTR1
11	glucocorticoid biosynthetic process	GO:006704	10.0	HSD11B2, CYP11B1, CYP17A1, CYP21A2
12	regulation of renal output by angiotensin	GO:002019	10.0	ACE, AGT
13	regulation of vasoconstriction	GO:019229	9.9	ACE, AGT, AGTR1
14	regulation of blood vessel size by renin-angiotensin	GO:002034	9.8	AGTR1, AGT
15	potassium ion transport	GO:006813	9.7	SLC12A1, KCNJ5, KCNK9, KCNJ1
16	excretion	GO:007588	9.6	CLCNKB, KCNJ1, SCNN1G, AGT
17	positive regulation of cellular protein metabolic process	GO:032270	9.6	AGTR1, AGT, INS
18	regulation of renal sodium excretion	GO:035813	9.5	AGTR1, AGT
19	positive regulation of respiratory burst	GO:060267	9.5	INSR, INS
20	kidney development	GO:001822	9.0	AGTR1, AGT, ACE, APC, REN
21	G-protein coupled receptor signaling pathway	GO:007186	8.0	AGTR1, AGT, GNRHR, GNA12, HTR4, GPR37

Molecular functions related to hyperaldosteronism according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	bradykinin receptor binding	GO:031711	10.2	AGTR1, ACE
2	steroid 11-beta-monooxygenase activity	GO:004507	10.2	CYP11B1, CYP11B2
3	acetyltransferase activator activity	GO:010698	9.9	AGTR1, AGT
4	heme binding	GO:020037	9.9	CYP11B2, CYP11B1, CYP17A1, CYP21A2
5	iron ion binding	GO:005506	9.8	TH, CYP21A2, CYP17A1, CYP11B1, CYP11B2
6	steroid binding	GO:005496	9.7	HSD11B2, CYP21A2, NR3C2
7	insulin-like growth factor receptor binding	GO:005159	9.4	REN, INS, INSR
8	hormone activity	GO:005179	8.8	NPPA, POMC, AGT, INS