MCID: HYP065
MIFTS: 57

Hyperaldosteronism malady

Genetic diseases, Endocrine diseases, Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Hyperaldosteronism

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards: Hyperaldosteronism is related to hypertension and adenoma. An important gene associated with Hyperaldosteronism is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Steroid hormone biosynthesis and superpathway of steroid hormone biosynthesis. The drugs spironolactone and spironolactone pwdr and the compounds 18-oxocortisol and 18-hydroxycortisol have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and kidney, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Wikipedia:65 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

Aliases & Classifications for Hyperaldosteronism

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Hyperaldosteronism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hyperaldosteronism, Familial, Type Iii family:

hyperaldosteronism Familial Hyperaldosteronism Type 2
Familial Hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.0CYP11B2, AGTR1, REN, POMC, CYP11B1
2adenoma30.8POMC, REN, KCNJ5, CYP11B2, CYP11B1
3essential hypertension30.6AGTR1, REN, CYP11B2, CYP11B1
4hypokalemia30.6CYP11B2, POMC, REN
5conn's syndrome30.5CYP11B1, REN, CYP11B2, POMC, AGTR1
6adrenal adenoma30.5REN, AGTR1, POMC, CYP11B1
7glucocorticoid-remediable aldosteronism30.4CYP11B2, REN, POMC, CYP11B1
8adrenocortical carcinoma30.4CYP11B1, CYP11B2, POMC
9low renin hypertension30.4CYP11B2, REN
10congestive heart failure29.8CYP11B2, REN, AGTR1
11cushing's syndrome29.7REN, CYP11B2, CYP11B1, POMC
12diabetes mellitus29.7POMC, REN, KCNJ5, AGTR1
13familial hyperaldosteronism10.7
14familial hyperaldosteronism type 210.5
15hyperaldosteronism, familial, type iii10.4
16hyperparathyroidism10.3
17pheochromocytoma10.3
18primary hyperparathyroidism10.2
19bartter syndrome, type 210.2
20kidney disease10.1
21myopathy10.1
22myocardial stunning10.1KCNJ5
23fibromuscular dysplasia10.1REN
24portal hypertension10.1REN
25acute adrenal insufficiency10.1POMC
26cystic fibrosis10.1
27polyarteritis nodosa10.1
28polycystic kidney disease10.1
29apparent mineralocorticoid excess syndrome10.1
30hyperprolactinemia10.1
31adrenal carcinoma10.1
32peritonitis10.1
33sleep apnea10.1
34bartter syndrome type 310.1
35hypocalcemia, autosomal dominant10.1
36bartter syndrome type 4a10.1
37endotheliitis10.1
38renal tubular dysgenesis10.0AGTR1, REN
39renovascular hypertension10.0AGTR1, REN
40coronary artery disease10.0KCNJ5, AGTR1
41renal fibrosis10.0AGTR1, REN
42glomerulosclerosis10.0REN, AGTR1
43congenital heart disease10.0KCNJ5, AGTR1
44primary hyperoxaluria10.0AGTR1, REN
45precocious puberty10.0POMC, CYP11B1
46septic shock10.0KCNJ5, POMC
47acute myocardial infarction10.0AGTR1, KCNJ5
48hypoglycemia10.0KCNJ5, POMC
49diabetic nephropathy10.0REN, AGTR1
50hyperinsulinism10.0KCNJ5, AGTR1

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to hyperaldosteronism

Symptoms for Hyperaldosteronism

About this section

Drugs & Therapeutics for Hyperaldosteronism

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hyperaldosteronism

Search NIH Clinical Center for Hyperaldosteronism

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hyperaldosteronism

About this section

Anatomical Context for Hyperaldosteronism

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hyperaldosteronism:

33
Adrenal gland, Testes, Kidney, Pituitary, Heart, Adrenal cortex, Cortex, Endothelial, Colon, Liver, Hypothalamus, Skin

Animal Models for Hyperaldosteronism or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Hyperaldosteronism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5AGTR1, REN, POMC, CYP11B1, CYP11B2
2MP:00053677.4CYP11B2, CYP11B1, POMC, REN, AGTR1
3MP:00053787.2CYP11B2, CYP11B1, POMC, REN, AGTR1
4MP:00053857.1AGTR1, REN, POMC, KCNJ5, CYP11B1, CYP11B2

Publications for Hyperaldosteronism

About this section
Sources:
52PubMed
See all sources

Articles related to Hyperaldosteronism:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Hyperaldosteronism as a common cause of resistant hypertension. (23092384)
2013
2
Image-guided ablation of Conn's adenomas in the management of primary hyperaldosteronism. (23218647)
2013
3
The Vascular Surgeon's Experience with Adrenal Venous Sampling for the Diagnosis of Primary Hyperaldosteronism. (24355161)
2013
4
Outcome of Surgery for Primary Hyperaldosteronism. (22286966)
2012
5
Primary hyperaldosteronism among Chinese hypertensive patients: how are we doing in a local district in Hong Kong. (22665682)
2012
6
The clinical utility of two renin mass methods to detect primary hyperaldosteronism compared with renin activity. (21427267)
2011
7
Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism. (20339375)
2010
8
Hyperaldosteronism in an adolescent with Gardner's syndrome. (19433155)
2009
9
Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma. (19180717)
2008
10
Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism. (18312153)
2008
11
Primary hyperaldosteronism in patients with resistant hypertension may be less prevalent than previously reported: evidence against an epidemic. (18780479)
2008
12
Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families. (18622235)
2008
13
Noninvasive adrenal imaging in hyperaldosteronism. (18366979)
2008
14
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. (18307725)
2008
15
Primary hyperaldosteronism: returning to the limelight? (17541333)
2007
16
High frequency of primary hyperaldosteronism among hypertensive patients from a primary care area in Sweden. (16923624)
2006
17
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
18
Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. (15745200)
2005
19
Comparison of active renin concentration and plasma renin activity for the diagnosis of primary hyperaldosteronism in patients with an adrenal mass. (15080782)
2004
20
Hypokalemic quadriparesis with normotensive primary hyperaldosteronism. (15321042)
2004
21
Primary hyperaldosteronism. (14503982)
2003
22
Does the treatment of primary hyperaldosteronism influence glucose tolerance? (12899664)
2003
23
Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension. (10999827)
2000
24
Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. (10843166)
2000
25
Laparoscopic vs open adrenalectomy for the treatment of primary hyperaldosteronism. (10367872)
1999
26
Bilateral adrenal cortical adenomas in primary hyperaldosteronism. (9763101)
1998
27
Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism. (9380281)
1997
28
Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism]. (8949378)
1996
29
Primary hyperaldosteronism in pregnancy. A case report. (8728078)
1996
30
Restoration by corticosteroids of the hyperaldosteronism in hyponatraemic rats with panhypopituitarism. (7834996)
1994
31
Chronic sennoside treatment does not cause habituation and secondary hyperaldosteronism in rats. (8234425)
1993
32
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity. (1472060)
1992
33
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
34
Secondary hyperaldosteronism stimulates acidification in rat distal colon. (2174145)
1990
35
Study on clinical and endocrine characteristics of dexamethasone-suppressible hyperaldosteronism compared with those in primary aldosteronism owing to aldosterone-producing adenoma. (2552725)
1989
36
Dexamethasone-suppressible hyperaldosteronism: pathophysiology, clinical aspects, and new insights into the pathogenesis. (3037179)
1987
37
Aldosterone receptors in different types of primary hyperaldosteronism. (3034947)
1987
38
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. (3012766)
1986
39
Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with essential low-renin hypertension and idiopathic hyperaldosteronism. (3882312)
1985
40
Primary adrenal hyperplasia: a new subset of primary hyperaldosteronism. (6707184)
1984
41
Effect of chronic hyperaldosteronism on the electrophysiology of rat distal colon. (6089088)
1984
42
Primary hyperparathyroidism associated with primary hyperaldosteronism. (6349207)
1983
43
Effect of standard oral glucose loading on aldosterone secretion in primary hyperaldosteronism. (6751010)
1982
44
Hyperaldosteronism in ketoacidosis and in poorly controlled non-ketotic diabetes. (6809687)
1982
45
Adrenal glomerulosa function in patients with dexamethasone-suppressible hyperaldosteronism. (7016891)
1981
46
Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism. (6987607)
1980
47
Primary hyperparathyroidism: possible cause of primary hyperaldosteronism in a 60-year-old woman. (6991517)
1980
48
Acute intermittent porphyria associated with inappropriate antidiuretic hormone secretion, hypokalemic alkalosis, and secondary hyperaldosteronism. (472850)
1979
49
Hyperreninemia and secondary hyperaldosteronism in pheochromocytomas. (762609)
1979
50
Differentiation between subtypes of primary hyperaldosteronism by multiple steroid measurement after dexamethasone administration. (713414)
1978

Variations for Hyperaldosteronism

About this section

Expression for genes affiliated with Hyperaldosteronism

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperaldosteronism

Search GEO for disease gene expression data for Hyperaldosteronism.

Pathways for genes affiliated with Hyperaldosteronism

About this section
Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB, 60Thomson Reuters
See all sources

Pathways related to Hyperaldosteronism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
9.5CYP11B2, CYP11B1
2
Show member pathways
estradiol biosynthesis II38
androgen biosynthesis38
estradiol biosynthesis I38
progesterone biosynthesis38
9.5CYP11B2, CYP11B1
39.2POMC, CYP11B1
4
Show member pathways
9.0REN, POMC
5
Show member pathways
8.8AGTR1, REN, CYP11B2
6
Show member pathways
8.7POMC, CYP11B1, CYP11B2
7
Show member pathways
8.7POMC, CYP11B1, CYP11B2
8
Show member pathways
8.7CYP11B2, CYP11B1, POMC

Compounds for genes affiliated with Hyperaldosteronism

About this section
Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
118-oxocortisol459.8CYP11B1, CYP11B2
218-hydroxycortisol459.8CYP11B1, CYP11B2
319-oic-deoxycorticosterone249.8CYP11B2, CYP11B1
419-Hydroxydeoxycorticosterone249.7CYP11B2, CYP11B1
519-Oxo-deoxycorticosterone249.7CYP11B2, CYP11B1
618-hydroxydeoxycorticosterone459.7CYP11B2, CYP11B1
711b,17a,21-Trihydroxypreg-nenolone249.5CYP11B2, CYP11B1
8aldosterone29 24 1111.4CYP11B2, CYP11B1, AGTR1
9tetrahydroaldosterone459.3CYP11B2, REN
10nitroglycerin45 1110.2KCNJ5, REN, AGTR1
11metoclopramide45 51 1111.2REN, CYP11B2, CYP11B1
12eplerenone45 61 29 1112.2REN, AGTR1, CYP11B2
13benazepril45 51 1111.2CYP11B2, AGTR1, REN
1411b-Hydroxyandrost-4-ene-3,17-dione249.2CYP11B2, CYP11B1
15hydralazine45 51 1111.2CYP11B2, REN, AGTR1
16atenolol45 51 29 24 1113.2CYP11B2, REN, AGTR1
17irbesartan45 29 51 1112.2AGTR1, REN, CYP11B2
18candesartan45 51 29 1112.1AGTR1, REN, CYP11B2
19hydrochlorothiazide45 29 51 24 1113.1CYP11B2, REN, AGTR1
2021-deoxycortisol45 2410.1CYP11B1, POMC, CYP11B2
21ang ii459.1REN, AGTR1, CYP11B2
22etomidate45 1110.1CYP11B1, CYP11B2, POMC
23cortisol29 2410.1POMC, CYP11B1, CYP11B2
24metyrapone45 61 1111.0CYP11B1, POMC, CYP11B2
25methacholine45 51 1111.0REN, KCNJ5, AGTR1
26fludrocortisone45 29 1110.9REN, POMC, CYP11B2
273beta-hydroxysteroid458.9CYP11B2, CYP11B1, POMC
28furosemide45 61 29 51 24 1113.8REN, AGTR1, POMC
29nifedipine45 29 51 1111.8KCNJ5, REN, AGTR1, CYP11B2
30cortisone45 249.6AGTR1, POMC, CYP11B1, CYP11B2
31clonidine45 51 29 1111.6REN, POMC, AGTR1
3218-hydroxycorticosterone45 249.5POMC, REN, CYP11B1, CYP11B2
3311 deoxycortisol458.5CYP11B1, REN, POMC, CYP11B2
34doca458.5CYP11B1, REN, POMC, CYP11B2
3517-hydroxyprogesterone45 249.5REN, POMC, CYP11B1, CYP11B2
36androstenedione45 249.5CYP11B2, CYP11B1, POMC, REN
37corticosterone45 61 2410.5POMC, CYP11B2, REN, CYP11B1
38hydrocortisone45 3 61 1111.4CYP11B2, CYP11B1, POMC, REN
39potassium45 24 1110.4CYP11B2, KCNJ5, REN, AGTR1, CYP11B1
40sodium45 249.3AGTR1, KCNJ5, CYP11B1, CYP11B2, REN
41haloperidol45 51 29 3 1112.0AGTR1, POMC, CYP11B2, KCNJ5, REN
42norepinephrine45 24 1110.0REN, AGTR1, POMC, KCNJ5, CYP11B2
43spironolactone45 61 29 51 1112.0CYP11B1, CYP11B2, POMC, AGTR1, REN
4411beta-hydroxysteroid458.0AGTR1, REN, POMC, CYP11B1, CYP11B2
45acth458.0REN, POMC, CYP11B1, CYP11B2, AGTR1
46estradiol45 24 1110.0POMC, CYP11B1, REN, AGTR1
47forskolin45 51 119.9REN, CYP11B2, AGTR1, CYP11B1, POMC
48dexamethasone45 51 29 1110.9POMC, CYP11B1, REN, AGTR1, CYP11B2
49arginine457.9CYP11B1, CYP11B2, REN, AGTR1, POMC
50glucose457.7AGTR1, CYP11B2, KCNJ5, POMC, REN

GO Terms for genes affiliated with Hyperaldosteronism

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Hyperaldosteronism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cortisol biosynthetic processGO:0346519.7CYP11B2, CYP11B1
2aldosterone biosynthetic processGO:0323429.7CYP11B2, CYP11B1
3mineralocorticoid biosynthetic processGO:0067059.7CYP11B1, CYP11B2
4cellular response to potassium ionGO:0358659.6CYP11B2, CYP11B1
5C21-steroid hormone biosynthetic processGO:0067009.6CYP11B1, CYP11B2
6sterol metabolic processGO:0161259.6CYP11B1, CYP11B2
7renin-angiotensin regulation of aldosterone productionGO:0020189.5AGTR1, REN
8cellular response to hormone stimulusGO:0328709.5CYP11B2, CYP11B1
9xenobiotic metabolic processGO:0068059.5CYP11B1, CYP11B2
10steroid metabolic processGO:0082029.4CYP11B1, CYP11B2
11kidney developmentGO:0018229.0AGTR1, REN
12regulation of blood pressureGO:0082178.8REN, POMC, CYP11B1

Molecular functions related to Hyperaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.5CYP11B1, CYP11B2
2steroid 11-beta-monooxygenase activityGO:0045079.2CYP11B1, CYP11B2

Products for genes affiliated with Hyperaldosteronism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperaldosteronism

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet