MCID: HYP065
MIFTS: 50

Hyperaldosteronism

Categories: Endocrine diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Hyperaldosteronism

MalaCards integrated aliases for Hyperaldosteronism:

Name: Hyperaldosteronism 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:446
ICD10 33 E26 E26.9
ICD9CM 35 255.1 255.10
MeSH 42 D006929
NCIt 47 C113213
UMLS 69 C0020428

Summaries for Hyperaldosteronism

Disease Ontology : 12 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.

MalaCards based summary : Hyperaldosteronism is related to pheochromocytoma and myocardial infarction. An important gene associated with Hyperaldosteronism is CYP11B2 (Cytochrome P450 Family 11 Subfamily B Member 2), and among its related pathways/superpathways are Peptide hormone metabolism and Corticotropin-releasing hormone signaling pathway. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and prostate, and related phenotypes are cardiovascular system and behavior/neurological

Wikipedia : 72 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

Related Diseases for Hyperaldosteronism

Diseases in the Hyperaldosteronism family:

Hyperaldosteronism, Familial, Type Ii Hyperaldosteronism, Familial, Type Iii
Hyperaldosteronism, Familial, Type Iv Familial Hyperaldosteronism

Diseases related to Hyperaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
id Related Disease Score Top Affiliating Genes
1 pheochromocytoma 29.5 MEN1 NPPA POMC
2 myocardial infarction 28.0 ACE AGTR1 NPPA NR3C2 REN
3 hyperaldosteronism, familial, type iii 12.4
4 familial hyperaldosteronism 12.3
5 hyperaldosteronism, familial, type ii 12.2
6 hyperaldosteronism, familial, type iv 12.1
7 conn's syndrome 12.0
8 aldosteronism, glucocorticoid-remediable 12.0
9 aldosterone-producing adenoma 11.3
10 liddle syndrome 10.9
11 congenital chloride diarrhea 10.7
12 hyper-reninism 10.7
13 spastic ataxia 2 10.7 CYP11B1 CYP11B2
14 cystic fibrosis and congenital absence of the vas deferens 10.5 AGTR1 REN
15 marden-walker syndrome 10.5 NR3C2 REN
16 hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 10.5 NR3C2 REN
17 long qt syndrome 13 10.5 NR3C2 REN
18 repetitive stress injuries 10.5 NPPA REN
19 female breast upper-outer quadrant cancer 10.5 AGTR1 KCNJ5
20 branchiootorenal/branchiootic syndrome 10.4 CYP11B2 KCNJ5 REN
21 monosomy 13q34 10.4 POMC REN
22 carotid artery thrombosis 10.4 POMC REN
23 cholangiolocellular carcinoma 10.4 POMC REN
24 pfeiffer syndrome 10.4 CYP11B1 POMC
25 smith-mccort dysplasia 2 10.4 MEN1 NR3C2
26 hypothyroidism due to iodide transport defect 10.4 ACE REN
27 primary hyperoxaluria 10.3 ACE REN
28 adenoma 10.3
29 dressler's syndrome 10.3 POMC REN
30 mody, type ii 10.3 ACE REN
31 listeriosis 10.3 ACE REN
32 non-congenital cyst of kidney 10.3 ACE REN
33 early onset absence epilepsy 10.3 CACNA1H POMC
34 bronchiectasis with or without elevated sweat chloride 1 10.3 CYP11B2 NR3C2 REN
35 familial hypopituitarism 10.3 POMC REN
36 cataract, autosomal dominant congenital 4 10.3 ACE AGTR1
37 benign peritoneal mesothelioma 10.2 CYP11B1 CYP11B2 POMC
38 potato nose 10.2 ACE AGTR1
39 voyeurism 10.2 ACE REN
40 perrault syndrome 10.2 AGTR1 NR3C2 REN
41 epithelial predominant pulmonary blastoma 10.2 ACE NPPA
42 trichinosis 10.2 ACE AGTR1
43 strabismus 10.1 MEN1 POMC
44 uterine corpus adenocarcinofibroma 10.1 POMC REN
45 retinitis pigmentosa 17 10.1 ACE AGTR1
46 hypokalemia 10.1
47 north american indian childhood cirrhosis 10.1 NR3C2 POMC REN
48 aortopulmonary window 10.1 ACE AGTR1 CYP11B2
49 adrenal adenoma 10.0
50 early-onset parkinson disease 10.0 MEN1 POMC

Comorbidity relations with Hyperaldosteronism via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Hyperaldosteronism:



Diseases related to Hyperaldosteronism

Symptoms & Phenotypes for Hyperaldosteronism

MGI Mouse Phenotypes related to Hyperaldosteronism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 MEN1 NPPA NR3C2 POMC REN ACE
2 behavior/neurological MP:0005386 9.97 ACE AGTR1 CACNA1H CYP11B1 CYP17A1 NR3C2
3 growth/size/body region MP:0005378 9.91 ACE AGTR1 CACNA1H CYP11B1 CYP11B2 MEN1
4 homeostasis/metabolism MP:0005376 9.85 NR3C2 POMC REN ACE AGTR1 CYP11B1
5 adipose tissue MP:0005375 9.71 ACE AGTR1 CYP11B2 POMC
6 muscle MP:0005369 9.43 CACNA1H CYP11B1 MEN1 NPPA NR3C2 REN
7 renal/urinary system MP:0005367 9.23 ACE AGTR1 CYP11B1 CYP11B2 NPPA NR3C2

Drugs & Therapeutics for Hyperaldosteronism

Drugs for Hyperaldosteronism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2 Racepinephrine Approved Phase 4,Phase 3,Phase 2
3
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Eplerenone Approved Phase 4,Phase 3 107724-20-9 150310 443872
6
Spironolactone Approved Phase 4,Phase 3 1952-01-7, 52-01-7 5833
7
Captopril Approved Phase 4 62571-86-2 44093
8
Losartan Approved Phase 4 114798-26-4 3961
9
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
10 Adrenergic Agents Phase 4,Phase 3,Phase 2
11 Adrenergic Agonists Phase 4,Phase 3,Phase 2
12 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
13 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
14 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
15 Autonomic Agents Phase 4,Phase 3,Phase 2
16 Bronchodilator Agents Phase 4,Phase 3,Phase 2
17 Epinephryl borate Phase 4,Phase 3,Phase 2
18 Mydriatics Phase 4,Phase 3,Phase 2
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
21 Respiratory System Agents Phase 4,Phase 3,Phase 2
22 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
23 Antiparkinson Agents Phase 4
24 Dopamine Agents Phase 4
25 Dopamine agonists Phase 4
26 Hormone Antagonists Phase 4,Phase 2,Phase 3
27 Hormones Phase 4,Phase 3,Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
29 diuretics Phase 4,Phase 3
30 Diuretics, Potassium Sparing Phase 4,Phase 3
31 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3
32 Mineralocorticoids Phase 4,Phase 3,Phase 2
33 Natriuretic Agents Phase 4,Phase 3
34 Angiotensin-Converting Enzyme Inhibitors Phase 4
35 Antihypertensive Agents Phase 4
36 HIV Protease Inhibitors Phase 4,Phase 2
37
protease inhibitors Phase 4,Phase 2
38 insulin Phase 4
39 Insulin, Globin Zinc Phase 4
40 Angiotensin II Type 1 Receptor Blockers Phase 4
41 Angiotensin Receptor Antagonists Phase 4
42 Angiotensinogen Phase 4
43 Anti-Arrhythmia Agents Phase 4
44 Coagulants Phase 4
45 Fertility Agents Phase 4
46 Kallikreins Phase 4
47
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2 50-23-7 5754 657311
48
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
49 Licorice Approved, Nutraceutical Phase 2, Phase 3
50
Enoxolone Investigational Phase 2, Phase 3 471-53-4 18526330

Interventional clinical trials:

(show top 50) (show all 68)

id Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4 bromocriptine
3 Does Aldosterone Cause Hypertension by a Non-Renal Mechanism? Unknown status NCT00553722 Phase 4 Eplerenone;Placebo
4 Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism Completed NCT00155064 Phase 4 captopril, Losartan (drug)
5 Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy Completed NCT03186742 Phase 4 Eplerenone 50 mg Tab
6 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
7 Aldosterone Antagonism and Microvascular Function Recruiting NCT01887119 Phase 4 Eplerenone
8 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
9 The Role of Mineralocorticoid Receptors in Vascular Function Completed NCT00759525 Phase 2, Phase 3 Glycyrrhetic Acid;Placebo
10 Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension Completed NCT00138944 Phase 3 placebo;eplerenone
11 Effect of Eplerenone on Endothelial Function in Metabolic Syndrome Completed NCT01319344 Phase 3 Eplerenone
12 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
13 Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism Completed NCT00732771 Phase 2 LCI699
14 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Recruiting NCT03174171 Phase 2 Everolimus 0.75 mg
15 Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to Chemotherapy Active, not recruiting NCT01867710 Phase 2 Abiraterone Acetate;Prednisone 5 mg twice daily;Prednisone 5 mg once daily;Prednisone 2.5 mg twice daily;Dexamethasone 0.5 mg once daily
16 Ph II Trial of Abiraterone Acetate Without Exogenous Glucocorticoids in Men With CRPC With Correlative Assessment of Hormone Intermediates. Active, not recruiting NCT02025010 Phase 2 abiraterone acetate;prednisone
17 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
18 Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Unknown status NCT01267747
19 Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism Unknown status NCT00173082
20 Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives. Unknown status NCT00407784 eplerenone
21 Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity Unknown status NCT00917345 captopril test
22 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
23 Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis Unknown status NCT02287363
24 Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome Unknown status NCT01021280
25 Primary Hyperaldosteronism and Ischemia-reperfusion Injury Completed NCT01978132
26 Optimizing Diagnosis Of Primary Aldosteronism Completed NCT02755519
27 Study of Myocardial Interstitial Fibrosis in Hyperaldosteronism Completed NCT02938910
28 The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism Completed NCT02216721
29 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
30 Study of CS-3150 in Patients With Primary Aldosteronism Completed NCT02885662 CS-3150
31 Intraoperative Analysis of Cortisol During Adrenal Vein Sampling Completed NCT01761344
32 Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable Aldosteronism Completed NCT00004354
33 Natural History of Apparent Mineralocorticoid Excess Syndrome Completed NCT00474942
34 Adrenal Vein Sampling International Study (AVIS Study) Completed NCT01234220
35 Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China Completed NCT01459042
36 Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment Completed NCT01897727 Spironolactone;BP medication uptitration
37 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501
38 Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure Completed NCT00001176
39 Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism Hypertension Completed NCT00005394
40 Cardiovascular Evaluation of Adult PHA 1 Patients Completed NCT00646828
41 ARBITRAGE : cARdiotoxicity Profile of aBIraTeRone in prostAte Cancer : a pharmacoviGilancE Study Completed NCT03243604 L02 (sex hormones used in treatment of neoplastic diseases) and G03 (sex hormones)
42 Aldosterone, Microvascular Function and Salt-sensitivity Completed NCT02068781
43 Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIV Completed NCT01407237 Angiotensin II Infusion
44 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Completed NCT01676025
45 Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics Completed NCT00276289 Spironolactone
46 Primary Aldosteronism In Hypertensive Patients in China Recruiting NCT03155139
47 Primary Aldosteronism in Western Norway Recruiting NCT02832388
48 Screening for Primary Aldosteronism in a Population of Patients With Hypertension Recruiting NCT03105531
49 Chongqing Primary Aldosteronism Study Recruiting NCT03224312
50 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists

Search NIH Clinical Center for Hyperaldosteronism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Hyperaldosteronism

Genetic tests related to Hyperaldosteronism:

id Genetic test Affiliating Genes
1 Hyperaldosteronism 29

Anatomical Context for Hyperaldosteronism

MalaCards organs/tissues related to Hyperaldosteronism:

39
Adrenal Gland, Testes, Prostate, Kidney, Endothelial, Pituitary, Heart

Publications for Hyperaldosteronism

Articles related to Hyperaldosteronism:

(show top 50) (show all 576)
id Title Authors Year
1
Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3. ( 27793677 )
2017
2
Arterial Hypertension, Atrial Fibrillation, and Hyperaldosteronism: The Triple Trouble. ( 28264920 )
2017
3
Hypothesis on a relationship between hyperaldosteronism, inflammation, somatic mutations, and autoimmunity. ( 28834202 )
2017
4
Effects of Eplerenone on Resistance to Antihypertensive Medication in Patients with Primary or Secondary Hyperaldosteronism. ( 28721341 )
2017
5
Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism. ( 28321294 )
2017
6
A Comparison of Robotic Versus Laparoscopic Adrenalectomy in Patients With Primary Hyperaldosteronism. ( 28727636 )
2017
7
NP-59 test for preoperative localization of primary hyperaldosteronism. ( 28224279 )
2017
8
A case of confirmed primary hyperaldosteronism diagnosed despite normal screening investigations. ( 28494487 )
2017
9
Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism. ( 28388725 )
2017
10
Familial hyperaldosteronism type III. ( 28447626 )
2017
11
Surgical treatment of posterior nutcracker syndrome presented with hyperaldosteronism. ( 26892192 )
2016
12
Histopathological classification of cross-sectional image negative hyperaldosteronism. ( 27967304 )
2016
13
Hyperaldosteronism: Screening and Diagnostic Tests. ( 26971505 )
2016
14
KCNK3 Variants Are Associated With Hyperaldosteronism and Hypertension. ( 27296998 )
2016
15
[OP.3D.04] ACTIVATED CD4+ AND CD8+ T-CELL SUBPOPULATIONS IN PATIENTS WITH PRIMARY HYPERALDOSTERONISM AND TRUE RESISTANT HYPERTENSION. ( 27508670 )
2016
16
Hypertension Cure Following Laparoscopic Adrenalectomy for Hyperaldosteronism is not Universal: Trends Over Two Decades. ( 27872977 )
2016
17
Hyperaldosteronism induces left atrial systolic and diastolic dysfunction. ( 27614224 )
2016
18
Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease. ( 27442639 )
2016
19
Genetics of primary hyperaldosteronism. ( 27485459 )
2016
20
Interrelationship Between Vitamin D Insufficiency, Calcium Homeostasis, Hyperaldosteronism, and Autoimmunity. ( 27097975 )
2016
21
Central serous chorioretinopathy in primary hyperaldosteronism. ( 27393297 )
2016
22
Cardiac Structure and Function in Hyperaldosteronism. ( 27307553 )
2016
23
Case Report: Nodule Development From Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism. ( 26580238 )
2016
24
Primary hyperaldosteronism: a case of unilateral adrenal hyperplasia with contralateral incidentaloma. ( 27417992 )
2016
25
Evaluation of a Recently Established Test for Familial Hyperaldosteronism Type 1. ( 27923252 )
2016
26
Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. ( 26962098 )
2016
27
Hyperaldosteronism: How to Discriminate Among Different Disease Forms? ( 27136934 )
2016
28
A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome. ( 27403928 )
2016
29
A Woman with Normotensive Primary Hyperaldosteronism. ( 26997605 )
2016
30
An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis. ( 26413177 )
2015
31
Netherton Syndrome in a Neonate with Possible Growth Hormone Deficiency and Transient Hyperaldosteronism. ( 26229701 )
2015
32
Primary hyperaldosteronism diagnosed with adrenal vein sampling. Characteristics and follow-up after adrenalectomy in a Danish study. ( 26471096 )
2015
33
Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype. ( 26252618 )
2015
34
Resolution of Hyperreninemia, Secondary Hyperaldosteronism, and Hypokalemia With 177Lu-DOTATATE Induction and Maintenance Peptide Receptor Radionuclide Therapy in a Patient With Pancreatic Neuroendocrine Tumor. ( 26359564 )
2015
35
Iatrogenic myxoedema madness following radioactive iodine ablation for Graves' disease, with a concurrent diagnosis of primary hyperaldosteronism. ( 26525086 )
2015
36
Cardiovascular Risk in Primary Hyperaldosteronism. ( 26575306 )
2015
37
NCI-H295R cell line as in vitro model of hyperaldosteronism lacks functional KCNJ5 (GIRK4; Kir3.4) channels. ( 25998841 )
2015
38
Diagnostic Performance of Multidetector Computed Tomography in Distinguishing Unilateral From Bilateral Abnormalities in Primary Hyperaldosteronism: Comparison of Multidetector Computed Tomography With Adrenal Vein Sampling. ( 25594382 )
2015
39
Incidental and Intentional Medicine Achieve SimilarA Results in Primary Hyperaldosteronism. ( 26193964 )
2015
40
Laparoendoscopic single-site adrenalectomy in patients with primary hyperaldosteronism: A prospective study with long-term follow up. ( 26626099 )
2015
41
An Update on Familial Hyperaldosteronism. ( 26445452 )
2015
42
6C.03: A CASE OF SEVERE HYPERALDOSTERONISM CAUSED BY A DE NOVO KCNJ5 MUTATION. ( 26102935 )
2015
43
Pure aldosterone-secreting adrenocortical carcinoma in a patient with refractory primary hyperaldosteronism. ( 26273475 )
2015
44
Galectin-3 Blockade Inhibits Cardiac Inflammation and Fibrosis in Experimental Hyperaldosteronism and Hypertension. ( 26238446 )
2015
45
A retrospective study of laparoscopic unilateral adrenalectomy for primary hyperaldosteronism caused by unilateral adrenal hyperplasia. ( 24488149 )
2014
46
Hyperaldosteronism and its association with hypotension and azotaemia in canine babesiosis. ( 25347616 )
2014
47
Gender differences in anxiety and depressive symptoms in patients with primary hyperaldosteronism: A cross-sectional study. ( 22568586 )
2014
48
A case of severe hyperaldosteronism caused by a de novo mutation affecting a critical 'salt bridge' Kir3.4 residue. ( 25322277 )
2014
49
4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. ( 25003119 )
2014
50
Is adrenal venous sampling mandatory before surgical decision in case of primary hyperaldosteronism? ( 24481990 )
2014

Variations for Hyperaldosteronism

Expression for Hyperaldosteronism

Search GEO for disease gene expression data for Hyperaldosteronism.

Pathways for Hyperaldosteronism

GO Terms for Hyperaldosteronism

Biological processes related to Hyperaldosteronism according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.73 CYP11B1 CYP11B2 CYP17A1
2 kidney development GO:0001822 9.7 ACE AGTR1 REN
3 steroid biosynthetic process GO:0006694 9.61 CYP11B1 CYP11B2 CYP17A1
4 cellular response to hormone stimulus GO:0032870 9.58 CACNA1H CYP11B1 CYP11B2
5 regulation of vasoconstriction GO:0019229 9.57 ACE AGTR1
6 beta-amyloid metabolic process GO:0050435 9.55 ACE REN
7 regulation of blood vessel diameter GO:0097746 9.54 ACE AGTR1
8 angiotensin maturation GO:0002003 9.51 ACE REN
9 sterol metabolic process GO:0016125 9.5 CYP11B1 CYP11B2 CYP17A1
10 C21-steroid hormone biosynthetic process GO:0006700 9.49 CYP11B1 CYP11B2
11 glucocorticoid biosynthetic process GO:0006704 9.48 CYP11B1 CYP17A1
12 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.46 ACE AGTR1
13 cellular response to potassium ion GO:0035865 9.43 CACNA1H CYP11B1 CYP11B2
14 renin-angiotensin regulation of aldosterone production GO:0002018 9.37 AGTR1 REN
15 aldosterone biosynthetic process GO:0032342 9.33 CACNA1H CYP11B1 CYP11B2
16 cortisol biosynthetic process GO:0034651 9.13 CACNA1H CYP11B1 CYP11B2
17 regulation of blood pressure GO:0008217 9.02 ACE CYP11B1 NPPA POMC REN

Molecular functions related to Hyperaldosteronism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.54 CYP11B1 CYP11B2 CYP17A1
2 heme binding GO:0020037 9.5 CYP11B1 CYP11B2 CYP17A1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP11B1 CYP11B2 CYP17A1
4 bradykinin receptor binding GO:0031711 9.16 ACE AGTR1
5 neuropeptide hormone activity GO:0005184 9.1 NPPA
6 corticosterone 18-monooxygenase activity GO:0047783 8.96 CYP11B1 CYP11B2
7 steroid 11-beta-monooxygenase activity GO:0004507 8.62 CYP11B1 CYP11B2

Sources for Hyperaldosteronism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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