MCID: HYP090
MIFTS: 44

Hyperalphalipoproteinemia malady

Genetic diseases, Metabolic diseases, Endocrine diseases, Rare diseases categories

Aliases & Classifications for Hyperalphalipoproteinemia

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Sources:
49OMIM, 11diseasecard, 47Novoseek, 24GTR, 51Orphanet, 65UMLS, 67UniProtKB/Swiss-Prot, 28ICD10 via Orphanet, 34MedGen, 36MeSH
See all sources

Aliases & Descriptions for Hyperalphalipoproteinemia:

Name: Hyperalphalipoproteinemia 49 11 47 24
Cholesteryl Ester Transfer Protein Deficiency 65 67
Hyperalphalipoproteinemia 1 65 67
Cholesterol-Ester Transfer Protein Deficiency 51
 
Familial Hyperalphalipoproteinemia 51
Cept Deficiency 51
Cetp Deficiency 67
Halp1 67


Classifications:



External Ids:

OMIM49 143470
Orphanet51 79506
ICD10 via Orphanet28 E78.4
MeSH36 D006951

Summaries for Hyperalphalipoproteinemia

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UniProtKB/Swiss-Prot:67 Hyperalphalipoproteinemia 1: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.

MalaCards based summary: Hyperalphalipoproteinemia, also known as cholesteryl ester transfer protein deficiency, is related to artery disease and hypertriglyceridemia, and has symptoms including autosomal dominant inheritanceand hyperalphalipoproteinemia. An important gene associated with Hyperalphalipoproteinemia is CETP (Cholesteryl Ester Transfer Protein, Plasma), and among its related pathways are Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF) and triacylglycerol degradation. Related mouse phenotypes are liver/biliary system and cardiovascular system.

Description from OMIM:49 143470

Related Diseases for Hyperalphalipoproteinemia

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Diseases in the Hyperalphalipoproteinemia family:

Cetp-Related Hyperalphalipoproteinemia

Diseases related to Hyperalphalipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1artery disease29.3APOA1, APOB, CETP, LDLR, PON1
2hypertriglyceridemia29.2APOA1, APOA2, APOB, APOC3, CETP, LDLR
3hypoalphalipoproteinemia28.6ABCA1, APOA1, APOA2, APOB, APOC3, CETP
4coronary artery disease28.2ABCA1, APOA1, APOA2, APOB, APOC3, CETP
5diabetes mellitus, noninsulin-dependent27.8ABCA1, APOA1, APOA2, APOB, APOC3, CETP
6apolipoprotein c-iii deficiency10.4
7hepatitis10.4
8cetp-related hyperalphalipoproteinemia10.2
9apolipoprotein c 2i deficiency10.2APOA1, LCAT
10spondylometaphyseal dysplasia, megarbane-dagher-melike type10.2LIPC, LPL
11atherosclerosis10.1
12amyloidosis beta2m10.1APOA1, LCAT
13hereditary antithrombin deficiency10.1APOA1, APOA2
14spinocerebellar ataxia 410.1APOA1, APOA2, LCAT
15amelogenesis imperfecta, type iia310.1APOA1, LIPC, LPL
16gallbladder sarcoma10.1APOA1, APOB, CETP
17fetal methimazole syndrome10.0APOA1, APOB, LCAT
18ischemic optic neuropathy10.0APOA1, APOB, LPL
19acute anterolateral myocardial infarction10.0APOA1, APOB
20necrobiosis lipoidica10.0APOB, LIPC, LPL
21hypercholesterolemia, due to ligand-defective apo b10.0APOB, LDLR
22adiponectin deficiency10.0
23coronary heart disease 610.0
24hypercholesterolemia, familial10.0
25peripheral vascular disease10.0
26aortic atherosclerosis10.0
27ischemic heart disease10.0
28spondylosis10.0
29generalized atherosclerosis10.0
30protein c deficiency10.0
31multiple symmetric lipomatosis10.0
32metabolic syndrome x10.0
33multiple symmetrical lipomatosis10.0
34carotid artery occlusion10.0
35aortic disease10.0
36arteriosclerosis10.0
37blood protein disease10.0
38carotid artery disease10.0
39familial hyperlipidemia10.0
40ischemia10.0
41lipid metabolism disorder10.0
42lipomatosis10.0
43nutritional deficiency disease10.0
44plasma protein metabolism disease10.0
45acdc10.0
46deficiency of n-glycanase 110.0APOB, LCAT, LDLR
47avascular necrosis of the femoral head9.9APOA1, APOB
48hypobetalipoproteinemia9.9APOB, LCAT, LDLR
49macrocephaly, alopecia, cutis laxa, and scoliosis9.9ABCA1, APOA1, APOC3, LCAT, SCARB1
50off-periods in parkinson disease not responding to oral treatment9.9APOA2, APOB, LDLR, LIPC

Graphical network of the top 20 diseases related to Hyperalphalipoproteinemia:



Diseases related to hyperalphalipoproteinemia

Symptoms for Hyperalphalipoproteinemia

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Symptoms by clinical synopsis from OMIM:

143470

Clinical features from OMIM:

143470

HPO human phenotypes related to Hyperalphalipoproteinemia:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 hyperalphalipoproteinemia HP:0012184

Drugs & Therapeutics for Hyperalphalipoproteinemia

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Drugs for Hyperalphalipoproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Adenosineapproved, investigational34058-61-760961
Synonyms:
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
1odi
2fqy
2gl0
30143-02-3
4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside
46946-45-6
46969-16-8
58-61-7
6-Amino-9-.beta.-ribofuranosyl-9H-purine
6-Amino-9-beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-delta-ribofuranosyl-9H-purine
9-(beta-D-Arabinofuranosyl)adenine
9-beta-D-Arabinofuranosyladenine
9-beta-D-Ribofuranosidoadenine
9-beta-D-Ribofuranosyl-9H-purin-6-amine
9-beta-D-Ribofuranosyladenine
9-beta-delta-Arabinofuranosyladenine
9-beta-delta-Ribofuranosidoadenine
9-beta-delta-Ribofuranosyl-9H-purin-6-amine
9-beta-delta-Ribofuranosyladenine
9beta-D-Ribofuranosyladenine
9beta-D-ribofuranosyl-9H-Purin-6-amine
9beta-delta-Ribofuranosyladenine
9beta-delta-ribofuranosyl-9H-Purin-6-amine
A0152
A4036_SIGMA
A9251_SIGMA
AC1L1U8O
AC1Q1ID3
AC1Q52XU
ADN
AI3-52413
Ade-Rib
Ade-rib
Adenin riboside
Adenine 9-beta-D-arabinofuranoside
Adenine deoxyribonucleoside
Adenine nucleoside
Adenine riboside
Adenine-9-beta-D-ribofuranoside
Adenine-9beta-D-Ribofuranoside
Adenine-9beta-delta-Ribofuranoside
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosina
Adenosine
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine, homopolymer
Adenosinum
Adensoine
Adenyldeoxyriboside
Ado
Adénosine
BB_NC-0565
BSPBio_001796
Bio1_000437
 
Bio1_000926
Bio1_001415
Boniton
C00212
CCRIS 2557
CHEBI:16335
CHEMBL477
CID60961
Caswell No. 010B
D000241
D00045
DB00640
Deoxyadenosine
Desoxyadenosine
EA6C60C2-6AFB-4264-A2F0-541373DB950E
EINECS 200-389-9
FT-0082881
HMS1920A13
HMS2091G13
KBio3_001296
LS-15085
MEDR-640
MLS000069638
MLS002153227
MolPort-001-838-229
Myocol
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NSC 627048
NSC 7652
NSC627048
NSC7652
Nucleocardyl
Pallacor
Polyadenosine
Polyriboadenosine
S1647_Selleck
SDCCGMLS-0003108.P003
SMR000058216
SPBio_001194
SPECTRUM1500107
SR 96225
SR-96225
SUN-Y4001
Sandesin
Spectrum2_001257
Spectrum3_000288
TL8003749
UNII-K72T3FS567
USAF CB-10
V0098
Vidarabine
ZINC02169830
adenine-D-ribose
adenosine
b-D-Adenosine
beta-Adenosine
beta-D-Adenosine
beta-D-Ribofuranoside, adenine-9
beta-delta-Adenosine
bmse000061
nchembio.143-comp9
nchembio.186-comp109
nchembio.2007.56-comp13
nchembio.64-comp4
nchembio706-5
2Albunex145

Interventional clinical trials:

idNameStatusNCT IDPhase
1Relationship Between CETP Deficiency and Atherosclerosis in Patients With HyperalphalipoproteinemiaRecruitingNCT01916512
2Genes Involved in Lipid DisordersRecruitingNCT02311335
3Causes and Natural History of DyslipidemiasRecruitingNCT00353782
4Mendelian Reverse Cholesterol Transport StudyRecruitingNCT01782027

Search NIH Clinical Center for Hyperalphalipoproteinemia

Genetic Tests for Hyperalphalipoproteinemia

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Genetic tests related to Hyperalphalipoproteinemia:

id Genetic test Affiliating Genes
1 Hyperalphalipoproteinemia24

Anatomical Context for Hyperalphalipoproteinemia

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Animal Models for Hyperalphalipoproteinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperalphalipoproteinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.9ABCA1, APOA1, APOB, LCAT, LDLR, LPL
2MP:00053856.0ABCA1, APOA1, APOB, APOC3, LCAT, LDLR
3MP:00053765.3ABCA1, APOA1, APOA2, APOB, APOC3, LCAT

Publications for Hyperalphalipoproteinemia

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Articles related to Hyperalphalipoproteinemia:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Improved plasma cholesterol efflux capacity from human macrophages in patients with hyperalphalipoproteinemia. (24674903)
2014
2
Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia. (23219720)
2013
3
Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia. (22464213)
2012
4
Novel mutations of CETP gene in Italian subjects with hyperalphalipoproteinemia. (18926541)
2009
5
Two novel mutations and functional analyses of the CETP and LIPC genes underlying severe hyperalphalipoproteinemia. (19428034)
2009
6
Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations. (18160998)
2008
7
Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians. (17192423)
2007
8
The two novel CETP mutations Gln87X and Gln165X in a compound heterozygous state are associated with marked hyperalphalipoproteinemia and absence of significant coronary artery disease. (16855848)
2006
9
Cholesteryl ester transfer protein gene mutations in Brazilian hyperalphalipoproteinemia. (16650090)
2006
10
Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical properties. (14739123)
2004
11
Prevalence and phenotypic spectrum of cholesteryl ester transfer protein gene mutations in Japanese hyperalphalipoproteinemia. (12482565)
2003
12
Distribution of human plasma PLTP mass and activity in hypo- and hyperalphalipoproteinemia. (12177167)
2002
13
A novel mutation in the intron 1 splice donor site of the cholesterol ester transfer protein (CETP) gene as a cause of hyperalphalipoproteinemia. (11887180)
2002
14
The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice. (10669644)
2000
15
Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia. (10998455)
2000
16
Elevated hepatic apolipoprotein A-I transcription is associated with diet-induced hyperalphalipoproteinemia in rabbits. (10809165)
2000
17
Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. (10606208)
1999
18
Hyperalphalipoproteinemia: characterization of a cardioprotective profile associating increased high-density lipoprotein2 levels and decreased hepatic lipase activity. (9711993)
1998
19
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. (9555865)
1998
20
Upregulated synthesis of both apolipoprotein A-I and apolipoprotein B in familial hyperalphalipoproteinemia and hyperbetalipoproteinemia. (9751249)
1998
21
Hyperalphalipoproteinemia and prostaglandin I2 stability. (9336872)
1997
22
Serum apolipoprotein E-rich HDL-C levels in the subjects with hyperalphalipoproteinemia]. (9311266)
1997
23
Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. (9194754)
1997
24
Cholesteryl ester transfer protein (CETP) deficiency and increased HDL cholesterol levels (hyperalphalipoproteinemia)]. (8847813)
1996
25
Atherosclerotic disease in marked hyperalphalipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. (7583564)
1995
26
Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. (7744879)
1995
27
Unsaturated fatty acids incorporated in HDL in hypo- and hyperalphalipoproteinemia--relation to the HDL-cholesterol level. (7778503)
1994
28
Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia. (8231838)
1993
29
Frequency of intron 14 splicing defect of cholesteryl ester transfer protein gene in the Japanese general population--relation between the mutation and hyperalphalipoproteinemia. (8318066)
1993
30
Rapid detection and prevalence of cholesteryl ester transfer protein deficiency caused by an intron 14 splicing defect in hyperalphalipoproteinemia. (8454281)
1993
31
Compound heterozygote of cholesteryl-ester transfer protein deficiency in a patient with hyperalphalipoproteinemia. (1418105)
1992
32
Association of a polymorphism in the Apo AI gene promoter with hyperalphalipoproteinemia. (1505654)
1992
33
Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. (2022742)
1991
34
A family of homozygous familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity. (2360880)
1990
35
Human apolipoprotein A-I gene promoter polymorphism: association with hyperalphalipoproteinemia. (1980685)
1990
36
High density lipoprotein metabolism in a rabbit model of hyperalphalipoproteinemia. (2920068)
1989
37
Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia. (2504859)
1989
38
Small polydisperse low density lipoproteins in familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity. (3355618)
1988
39
Decreased serum cholesteryl-ester transfer activity in a patient with familial hyperalphalipoproteinemia. (3193660)
1988
40
Type II hyperlipoproteinemia, hyperapobetalipoproteinemia, and hyperalphalipoproteinemia following renal transplantation: implications for atherogenic risk. (3303510)
1987
41
High density lipoproteins with poor reactivity to cholesteryl ester transfer reaction observed in a homozygote of familial hyperalphalipoproteinemia. (3789924)
1986
42
A pedigree of homozygous familial hyperalphalipoproteinemia. (6738363)
1984
43
Metabolic abnormalities in multiple symmetric lipomatosis: elevated lipoprotein lipase activity in adipose tissue with hyperalphalipoproteinemia. (6875381)
1983
44
Complex segregation analysis of hyperalphalipoproteinemia. (7078431)
1982
45
Hyperalphalipoproteinemia, birth to age to years. (7208170)
1981
46
Lipoproteins in familial hyperalphalipoproteinemia. (7295190)
1981
47
Hyperalphalipoproteinemia in hypercholesterolemic adults and children. (7245576)
1980
48
Neonatal familial hyperalphalipoproteinemia. (191726)
1977
49
Composition of HDL-2 and HDL-3 in familial hyperalphalipoproteinemia. (186077)
1976
50
Familial hyperalphalipoproteinemia. (168823)
1975

Variations for Hyperalphalipoproteinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hyperalphalipoproteinemia:

67
id Symbol AA change Variation ID SNP ID
1CETPp.Asp459GlyVAR_004172rs2303790
2CETPp.Leu168ProVAR_033099
3CETPp.Arg299CysVAR_033100

Clinvar genetic disease variations for Hyperalphalipoproteinemia:

5
id Gene Variation Type Significance SNP ID Assembly Location
1CETPCETP, IVS14DS, G-A, +1single nucleotide variantPathogenic
2CETPNM_000078.2(CETP): c.1376A> G (p.Asp459Gly)single nucleotide variantPathogenicrs2303790GRCh37Chr 16, 57017292: 57017292
3CETPCETP, 1-BP INS, T, IVS14, +3insertionPathogenic

Expression for genes affiliated with Hyperalphalipoproteinemia

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Search GEO for disease gene expression data for Hyperalphalipoproteinemia.

Pathways for genes affiliated with Hyperalphalipoproteinemia

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Pathways related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ABCA1, CETP
29.6LIPC, LIPG
39.6ABCA1, LDLR
49.5ABCA1, APOA1, APOA2
5
Show member pathways
9.5ABCA1, APOA1, SCARB1
69.4APOA1, APOB, SCARB1
7
Show member pathways
9.4APOA1, APOB, SCARB1
8
Show member pathways
9.1LIPC, LIPG, LPL
99.0ABCA1, APOA1, APOB, SCARB1
108.9APOA1, APOA2, APOC3, LPL, PLTP
11
Show member pathways
8.5ABCA1, APOA1, APOB, LDLR, SCARB1
12
Show member pathways
8.2APOA1, APOA2, APOB, APOC3, LDLR, LPL
13
Show member pathways
6.5ABCA1, APOA1, APOA2, APOB, APOC3, CETP
14
Show member pathways
6.5ABCA1, APOA1, APOA2, APOB, APOC3, CETP
15
Show member pathways
4.5ABCA1, APOA1, APOA2, APOB, APOC3, CETP

GO Terms for genes affiliated with Hyperalphalipoproteinemia

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Cellular components related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:003436310.5APOB, APOC3
2endocytic vesicle lumenGO:007168210.5APOA1, APOB
3low-density lipoprotein particleGO:00343629.7APOB, LDLR, PLA2G7
4blood microparticleGO:00725629.6APOA1, APOA2, PON1
5spherical high-density lipoprotein particleGO:00343669.5APOA1, APOA2, APOC3, PON1
6chylomicronGO:00426279.4APOA1, APOA2, APOB, APOC3, LPL
7very-low-density lipoprotein particleGO:00343619.4APOA1, APOA2, APOB, APOC3, LPL
8endoplasmic reticulum lumenGO:00057889.3APOA1, APOA2, APOB, LIPC
9high-density lipoprotein particleGO:00343648.9APOA1, APOA2, CETP, LCAT, LIPC, PON1
10early endosomeGO:00057698.4APOA1, APOA2, APOB, APOC3, LDLR, LIPG
11cell surfaceGO:00099868.2APOA1, LDLR, LIPG, LPL, SCARB1
12extracellular exosomeGO:00700627.1APOA1, APOA2, APOB, APOC3, CETP, LCAT
13extracellular regionGO:00055765.6APOA1, APOA2, APOB, APOC3, CETP, LCAT
14extracellular spaceGO:00056155.4APOA1, APOA2, APOB, APOC3, CETP, LCAT

Biological processes related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remnant clearanceGO:003438210.6APOC3, LIPC
2negative regulation of macrophage derived foam cell differentiationGO:001074510.5ABCA1, CETP
3negative regulation of lipid catabolic processGO:005099510.5APOA2, APOC3
4negative regulation of cholesterol importGO:006062110.5APOA2, APOC3
5negative regulation of cytokine secretion involved in immune responseGO:000274010.5APOA1, APOA2
6blood vessel endothelial cell migrationGO:004353410.5APOA1, SCARB1
7positive regulation of cholesterol esterificationGO:001087310.5APOA1, APOA2
8peptidyl-methionine modificationGO:001820610.5APOA1, APOA2
9regulation of intestinal cholesterol absorptionGO:003030010.5APOA1, APOA2
10negative regulation of lipase activityGO:006019210.5APOA1, APOA2
11protein oxidationGO:001815810.5APOA1, APOA2
12endothelial cell proliferationGO:000193510.4APOA1, SCARB1
13regulation of phosphatidylcholine catabolic processGO:001089910.3LDLR, SCARB1
14lipoprotein catabolic processGO:004215910.3APOB, LDLR
15positive regulation of triglyceride biosynthetic processGO:001086710.2LDLR, SCARB1
16negative regulation of very-low-density lipoprotein particle remodelingGO:001090310.2APOA1, APOA2, APOC3
17regulation of Cdc42 protein signal transductionGO:003248910.2ABCA1, APOA1, APOC3
18very-low-density lipoprotein particle assemblyGO:003437910.2APOB, APOC3
19high-density lipoprotein particle clearanceGO:003438410.1APOA1, APOA2, SCARB1
20phosphatidylcholine biosynthetic processGO:000665610.1APOA1, APOA2, LCAT
21high-density lipoprotein particle assemblyGO:003438010.1ABCA1, APOA1, APOA2
22positive regulation of macrophage derived foam cell differentiationGO:001074410.1APOB, LPL
23lipoprotein biosynthetic processGO:00421589.8ABCA1, APOA1, APOB, LCAT
24phospholipid effluxGO:00337009.8ABCA1, APOA1, APOA2, APOC3
25cholesterol importGO:00705089.8APOA1, LDLR, SCARB1
26phosphatidylcholine metabolic processGO:00464709.8CETP, LCAT, PON1
27positive regulation of cholesterol storageGO:00108869.8APOB, LPL, SCARB1
28low-density lipoprotein particle clearanceGO:00343839.7APOB, LDLR, SCARB1
29positive regulation of cholesterol effluxGO:00108759.7ABCA1, PLTP, PON1
30very-low-density lipoprotein particle remodelingGO:00343729.6APOA1, CETP, LCAT, LIPC, LPL
31phospholipid transportGO:00159149.6APOA1, CETP, LDLR, SCARB1
32phospholipid homeostasisGO:00550919.6ABCA1, APOA1, CETP, LIPG
33triglyceride metabolic processGO:00066419.6APOA2, APOC3, CETP, LPL
34lipid catabolic processGO:00160429.5APOB, LPL, PLA2G7
35low-density lipoprotein particle remodelingGO:00343749.3APOA2, APOB, CETP, LIPC, PLA2G7
36triglyceride catabolic processGO:00194339.3APOA1, APOB, APOC3, LIPC, LPL
37triglyceride homeostasisGO:00703289.2APOA1, APOC3, CETP, LIPC, LPL, SCARB1
38cholesterol effluxGO:00333449.1ABCA1, APOA1, APOA2, APOB, APOC3, SCARB1
39lipid transportGO:00068698.9APOA1, APOA2, APOB, APOC3, CETP, PLTP
40receptor-mediated endocytosisGO:00068988.7APOA1, APOB, CETP, LDLR, SCARB1
41retinoid metabolic processGO:00015238.5APOA1, APOA2, APOB, APOC3, LDLR, LPL
42phototransduction, visible lightGO:00076038.5APOA1, APOA2, APOB, APOC3, LDLR, LPL
43cholesterol transportGO:00303018.3APOA1, APOA2, APOB, CETP, LCAT, LDLR
44high-density lipoprotein particle remodelingGO:00343758.2APOA1, APOA2, APOC3, CETP, LCAT, LIPC
45reverse cholesterol transportGO:00436918.1ABCA1, APOA1, APOA2, APOC3, CETP, LCAT
46cholesterol metabolic processGO:00082038.1ABCA1, APOA1, APOA2, APOB, CETP, LCAT
47lipoprotein metabolic processGO:00421577.6ABCA1, APOA1, APOA2, APOB, APOC3, CETP
48lipid metabolic processGO:00066297.2APOB, LCAT, LDLR, LIPC, LIPG, LPL
49cholesterol homeostasisGO:00426327.1ABCA1, APOA1, APOA2, APOB, APOC3, CETP
50small molecule metabolic processGO:00442816.6ABCA1, APOA1, APOA2, APOB, APOC3, CETP

Molecular functions related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1triglyceride bindingGO:001712910.4CETP, LPL
2apolipoprotein receptor bindingGO:003419010.3APOA1, APOA2
3phosphatidylcholine-sterol O-acyltransferase activator activityGO:006022810.3APOA1, APOA2
4apolipoprotein A-I bindingGO:003418610.1ABCA1, LCAT, SCARB1
5phospholipid transporter activityGO:000554810.1ABCA1, APOA1, CETP
6triglyceride lipase activityGO:000480610.1LIPC, LPL
7lipase inhibitor activityGO:005510210.1APOA1, APOA2, APOC3
8high-density lipoprotein particle receptor bindingGO:007065310.1APOA1, APOA2, APOC3
9lipoprotein lipase activityGO:000446510.0LIPG, LPL
10phosphatidylcholine bindingGO:00312109.9APOA1, APOA2, CETP
11high-density lipoprotein particle bindingGO:00080359.8APOA1, APOA2, SCARB1
12phospholipase activityGO:00046209.7LIPC, LIPG, LPL
13low-density lipoprotein particle bindingGO:00301699.6LDLR, LIPC, SCARB1
14lipid transporter activityGO:00053199.6APOA1, APOA2, APOB, CETP
15cholesterol bindingGO:00154859.5ABCA1, APOA1, APOA2, APOC3, CETP
16apolipoprotein bindingGO:00341859.5ABCA1, LIPC, LPL, SCARB1
17carboxylic ester hydrolase activityGO:00526899.4LIPC, LIPG, LPL
18cholesterol transporter activityGO:00171279.3ABCA1, APOA1, APOA2, APOB, CETP
19lipid bindingGO:00082898.7APOA1, APOA2, APOB, APOC3, CETP, PLTP
20heparin bindingGO:00082018.6APOB, LIPC, LIPG, LPL
21phospholipid bindingGO:00055437.5ABCA1, APOA1, APOA2, APOB, APOC3, PLA2G7

Sources for Hyperalphalipoproteinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet