MCID: HYP090
MIFTS: 43

Hyperalphalipoproteinemia malady

Metabolic, Endocrine, Genetic categories

Summaries for Hyperalphalipoproteinemia

Sources:
47OMIM, 33MalaCards
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MalaCards: Hyperalphalipoproteinemia, also known as cholesterol-ester transfer protein deficiency, is related to familial combined hyperlipidemia and familial hypertriglyceridemia. An important gene associated with Hyperalphalipoproteinemia is CETP (cholesteryl ester transfer protein, plasma), and among its related pathways are Golgi to ER Retrograde Transport and Scavenging by Class A Receptors. The compounds rosiglitazone and palmitate have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Description from OMIM:47 143470,614028

Aliases & Classifications for Hyperalphalipoproteinemia

Sources:
47OMIM, 45Novoseek, 61UMLS, 49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Metabolic, Endocrine


Aliases & Descriptions:

hyperalphalipoproteinemia 47 45 61
cholesterol-ester transfer protein deficiency 49
familial hyperalphalipoproteinemia 49
cept deficiency 49


External Ids:

ICD10 via Orphanet26 E78.4

Related Diseases for Hyperalphalipoproteinemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hyperalphalipoproteinemia family:

hyperalphalipoproteinemia 2

Diseases related to Hyperalphalipoproteinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1familial combined hyperlipidemia29.9APOA1, APOB
2familial hypertriglyceridemia29.9APOC3, APOB, LPL
3hypertriglyceridemia29.9APOC3, APOA1, LCAT, APOA2, APOB, LPL
4hypoalphalipoproteinemia29.9LCAT, APOA1, APOC3, LDLR, CETP, PLTP
5coronary artery disease,29.8LDLR, CETP, PLTP, ABCA1, LIPC, CRP
6atherosclerosis29.8APOC3, LCAT, APOA1, APOA2, LDLR, CETP
7protein c deficiency10.3
8hyperalphalipoproteinemia 210.2
9cetp-related hyperalphalipoproteinemia10.1
10hyperapobetalipoproteinemia10.1
11thromboembolism10.0APOA1
12alcohol abuse10.0LCAT
13age related macular degeneration10.0LIPC
14polyneuropathy10.0APOA2
15hepatitis10.0LDLR
16peritonitis10.0CRP
17hyperhomocysteinemia10.0CRP
18hyperuricemia10.0APOB
19schizophrenia10.0LDLR
20fatty liver disease10.0CRP
21eye disease10.0CRP
22kawasaki disease10.0CRP
23alagille syndrome10.0LCAT, APOA1
24chylomicron retention disease10.0APOB
25psoriasis10.0LDLR
26aortic aneurysm10.0CRP
27viral hepatitis10.0LCAT
28antiphospholipid syndrome10.0LDLR, PLTP
29lipoprotein lipase deficiency10.0LPL
30liver cirrhosis10.0LCAT, CETP
31ischemic heart disease10.0LPL
32liposarcoma10.0CETP
33amyloidosis, renal10.0APOA2, APOA1
34galactosemia10.0LCAT, CRP
35hyperthyroidism10.0APOA2, LDLR
36complete lcat deficiency10.0APOA1, APOA2, LCAT
37fish-eye disease10.0LCAT, APOA2, APOA1
38cholestasis10.0CETP, LIPC, LCAT
39dementia10.0LPL, CETP
40arcus senilis10.0LCAT, APOB, APOA1
41peripheral vascular disease10.0CETP, APOB, APOA1
42amyloidosis, secondary10.0LCAT, CRP, APOA1
43polycystic ovary syndrome10.0APOA1, CRP, LIPC
44primary hyperoxaluria10.0LIPC, CETP, LCAT, APOC3
45familial hypercholesterolemia10.0CETP, APOB, LDLR
46metabolic syndrome x10.0LPL
47lipase deficiency combined10.0LPL, LIPC
48glucose intolerance10.0APOB, LPL
49coronary stenosis10.0APOB, LIPC, APOA1, CETP
50cystic fibrosis10.0LPL, ABCA1

Graphical network of the top 20 diseases related to Hyperalphalipoproteinemia:



Diseases related to hyperalphalipoproteinemia

Clinical Features for Hyperalphalipoproteinemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

143470,614028

Clinical synopsis from OMIM:

143470

Drugs & Therapeutics for Hyperalphalipoproteinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperalphalipoproteinemia

Drug clinical trials:

Search ClinicalTrials for Hyperalphalipoproteinemia

Search NIH Clinical Center for Hyperalphalipoproteinemia

Search CenterWatch for Hyperalphalipoproteinemia

Genetic Tests for Hyperalphalipoproteinemia

Anatomical Context for Hyperalphalipoproteinemia

Animal Models for Hyperalphalipoproteinemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hyperalphalipoproteinemia

Sources:
51PubMed
See all sources

Articles related to Hyperalphalipoproteinemia:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia. (23219720)
2013
2
Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia. (22464213)
2012
3
Novel mutations of CETP gene in Italian subjects with hyperalphalipoproteinemia. (18926541)
2009
4
Two novel mutations and functional analyses of the CETP and LIPC genes underlying severe hyperalphalipoproteinemia. (19428034)
2009
5
Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia. (19158204)
2009
6
Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations. (18160998)
2008
7
Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia. (19013296)
2008
8
Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians. (17192423)
2007
9
The two novel CETP mutations Gln87X and Gln165X in a compound heterozygous state are associated with marked hyperalphalipoproteinemia and absence of significant coronary artery disease. (16855848)
2006
10
Cholesteryl ester transfer protein gene mutations in Brazilian hyperalphalipoproteinemia. (16650090)
2006
11
Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical properties. (14739123)
2004
12
Prevalence and phenotypic spectrum of cholesteryl ester transfer protein gene mutations in Japanese hyperalphalipoproteinemia. (12482565)
2003
13
Plasma C-reactive protein in subjects with hypo/hyperalphalipoproteinemias. (12701054)
2003
14
Distribution of human plasma PLTP mass and activity in hypo- and hyperalphalipoproteinemia. (12177167)
2002
15
A novel mutation in the intron 1 splice donor site of the cholesterol ester transfer protein (CETP) gene as a cause of hyperalphalipoproteinemia. (11887180)
2002
16
ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. (11457883)
2001
17
The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice. (10669644)
2000
18
Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia. (10998455)
2000
19
Elevated hepatic apolipoprotein A-I transcription is associated with diet-induced hyperalphalipoproteinemia in rabbits. (10809165)
2000
20
Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. (10606208)
1999
21
Hyperalphalipoproteinemia: characterization of a cardioprotective profile associating increased high-density lipoprotein2 levels and decreased hepatic lipase activity. (9711993)
1998
22
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. (9555865)
1998
23
Upregulated synthesis of both apolipoprotein A-I and apolipoprotein B in familial hyperalphalipoproteinemia and hyperbetalipoproteinemia. (9751249)
1998
24
Hyperalphalipoproteinemia and prostaglandin I2 stability. (9336872)
1997
25
Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. (9194754)
1997
26
Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. (7744879)
1995
27
Unsaturated fatty acids incorporated in HDL in hypo- and hyperalphalipoproteinemia--relation to the HDL-cholesterol level. (7778503)
1994
28
A case of hyperalphalipoproteinemia associated with albumin complexing. (7840809)
1994
29
Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia. (8231838)
1993
30
Frequency of intron 14 splicing defect of cholesteryl ester transfer protein gene in the Japanese general population--relation between the mutation and hyperalphalipoproteinemia. (8318066)
1993
31
Rapid detection and prevalence of cholesteryl ester transfer protein deficiency caused by an intron 14 splicing defect in hyperalphalipoproteinemia. (8454281)
1993
32
Increased plasma apolipoprotein E-rich high-density lipoprotein and its effect on serum high-density lipoprotein cholesterol determination in patients with familial hyperalphalipoproteinemia due to cholesteryl ester transfer activity deficiency. (8439452)
1993
33
Compound heterozygote of cholesteryl-ester transfer protein deficiency in a patient with hyperalphalipoproteinemia. (1418105)
1992
34
Association of a polymorphism in the Apo AI gene promoter with hyperalphalipoproteinemia. (1505654)
1992
35
Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. (2022742)
1991
36
A family of homozygous familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity. (2360880)
1990
37
Human apolipoprotein A-I gene promoter polymorphism: association with hyperalphalipoproteinemia. (1980685)
1990
38
Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia. (2504859)
1989
39
Small polydisperse low density lipoproteins in familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity. (3355618)
1988
40
Decreased serum cholesteryl-ester transfer activity in a patient with familial hyperalphalipoproteinemia. (3193660)
1988
41
A familial hyperalphalipoproteinemia with low uptake of high density lipoproteins into peripheral lymphocytes. (3190815)
1988
42
Rate of cholesteryl ester transfer between high and low density lipoproteins in human serum and a case with decreased transfer rate in association with hyperalphalipoproteinemia. (3867663)
1985
43
A pedigree of homozygous familial hyperalphalipoproteinemia. (6738363)
1984
44
Metabolic abnormalities in multiple symmetric lipomatosis: elevated lipoprotein lipase activity in adipose tissue with hyperalphalipoproteinemia. (6875381)
1983
45
Complex segregation analysis of hyperalphalipoproteinemia. (7078431)
1982
46
Hyperalphalipoproteinemia, birth to age to years. (7208170)
1981
47
Lipoproteins in familial hyperalphalipoproteinemia. (7295190)
1981
48
Neonatal familial hyperalphalipoproteinemia. (191726)
1977
49
Composition of HDL-2 and HDL-3 in familial hyperalphalipoproteinemia. (186077)
1976
50
Familial hyperalphalipoproteinemia. (168823)
1975

Genetic Variations for Hyperalphalipoproteinemia

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Hyperalphalipoproteinemia:

63
id Symbol AA change Variation SNP ID
1CETPp.Asp459GlyVAR_004172rs2303790
2CETPp.Leu168ProVAR_033099
3CETPp.Arg299CysVAR_033100

Expression for genes affiliated with Hyperalphalipoproteinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperalphalipoproteinemia

Search GEO for disease gene expression data for Hyperalphalipoproteinemia.

Pathways for genes affiliated with Hyperalphalipoproteinemia

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Hyperalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CETP, ABCA1
29.6APOB, APOA1
39.6LDLR, ABCA1
49.5LIPC, LIPG
5
Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
9.4ABCA1, APOA2, APOA1
6
Hide members
9.4APOA1, APOA2, ABCA1
79.4APOA1, SCARB1, ABCA1
8
Hide members
9.3SCARB1, APOB, APOA1
99.3APOA1, APOB, SCARB1
109.3SCARB1, APOB, APOA1
119.3APOB, CETP, LDLR
128.9APOA1, APOB, SCARB1, ABCA1
13
Hide members
8.8SCARB1, LPL, LDLR
148.7LPL, LIPG, LIPC
158.5APOA1, APOC3, APOA2, LPL, PLTP
168.4APOA1, APOA2, APOB, CRP, ABCA1
177.9APOA1, APOB, SCARB1, CRP, ABCA1, LDLR
18
Hide members
7.8APOA1, APOC3, APOA2, APOB, LPL, LDLR
197.8APOA1, APOC3, APOA2, APOB, LPL, LDLR
20
Hide members
6.6LCAT, APOA1, APOC3, APOA2, APOB, SCARB1
21
Hide members
6.5CETP, ABCA1, LPL, SCARB1, APOB, APOA2
22
Hide members
5.9LDLR, LCAT, APOA1, CETP, PLTP, ABCA1

Compounds for genes affiliated with Hyperalphalipoproteinemia

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Hyperalphalipoproteinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1rosiglitazone45 50 29 11 2414.3SCARB1
2palmitate459.8LCAT, CETP, LDLR
3psyllium459.3APOB, LCAT, CETP, LDLR
4xbai459.3LPL, LDLR, APOC3
5cholestyramine459.1LDLR, CETP, APOC3, APOB
6p-opc459.1LIPG, LCAT, APOA2, APOA1, CETP
7mspi458.8APOA1, APOB, CETP, APOA2, LDLR, APOC3
8fenofibric acid45 299.7APOC3, LPL, APOA1, APOB
9alpha tocopherol458.7LDLR, PLTP, LPL, SCARB1, LCAT
10sele458.6APOC3, LPL, CETP, LDLR
11rosuvastatin45 50 29 1111.5APOA1, LDLR, CRP, CETP, APOC3, APOB
12retinyl palmitate45 249.5LPL, APOB, APOA1, LCAT
13taurocholate458.4APOB, LPL, SCARB1, APOA1, APOC3
14lycopene45 249.4CETP, SCARB1, LPL, LDLR, CRP
15tocopherol458.3SCARB1, LPL, LDLR, APOB, APOA1
16dextran sulfate458.2PLTP, APOB, APOA1, LPL, CETP, LDLR
17ciprofibrate45 299.1APOA1, APOB, LDLR, LPL
18ezetimibe45 119.1APOA1, APOB, SCARB1, CRP, ABCA1, CETP
19carbohydrates458.0APOC3, SCARB1, LDLR, CETP, LPL, LIPC
20fibrinogen457.9APOA1, APOA2, ABCA1, LIPC, CRP, APOB
21fluvastatin45 50 29 1110.9LPL, LDLR, APOB, APOA1, CRP, CETP
22sterol457.9APOB, ABCA1, LCAT, LIPC, CETP, LDLR
23pravastatin45 50 29 11 2411.9CETP, LCAT, APOA1, APOC3, APOB, CRP
24aspirin45 50 29 2410.9LDLR, APOA1, APOB, SCARB1, CETP, ABCA1
25stearic acid45 11 249.9LPL, LIPC, LIPG, CETP, LDLR, ABCA1
26lovastatin45 50 60 29 1111.9LPL, LIPC, CETP, APOA1, APOB, LDLR
27oleic acid45 29 11 2410.8LIPC, LPL, APOB, CETP, PLTP, LDLR
28intralipid457.8APOC3, APOA1, CETP, LIPC, LPL, APOB
29thyroxine45 248.8APOB, APOA1, LPL, LIPC, CETP, LDLR
30niacin45 118.8LDLR, CETP, ABCA1, LPL, APOA1, APOB
31gemfibrozil45 29 119.6APOA1, APOC3, APOA2, LDLR, CETP, LIPC
32pioglitazone45 50 29 1110.5LIPC, APOA1, APOB, SCARB1, CRP, ABCA1
33alanine457.1APOA1, CETP, PLTP, LIPG, CRP, SCARB1
34heparin45 29 11 2410.0LCAT, APOA2, APOB, LPL, LIPG, CETP
35estrogen456.9LDLR, APOC3, CETP, LIPC, LPL, APOA1
36probucol45 117.9LDLR, CETP, PLTP, ABCA1, LIPC, LPL
37vitamin a45 11 248.7LCAT, APOA1, APOC3, APOB, SCARB1, LPL
38simvastatin45 50 60 29 11 2411.7LCAT, APOA1, APOB, SCARB1, LPL, CRP
39glucose456.6APOA2, ABCA1, LIPC, PLTP, CRP, LPL
40triacylglycerol456.5APOA2, APOB, LPL, LIPG, LIPC, PLTP
41bezafibrate45 29 118.4LCAT, APOA1, APOC3, APOA2, APOB, LPL
42atorvastatin45 50 29 11 2410.3CRP, LIPC, ABCA1, CETP, LDLR, LPL
43testosterone45 60 11 249.3LPL, APOA1, APOC3, LCAT, APOB, LIPC
44cholesterol ester456.3LPL, LIPC, ABCA1, PLTP, CETP, LDLR
45fenofibrate45 50 118.1PLTP, CETP, LDLR, ABCA1, APOA1, APOC3
46fatty acid456.0LPL, LIPG, LIPC, ABCA1, PLTP, CETP
47phosphatidylcholine455.9LCAT, APOA1, APOA2, APOB, SCARB1, LPL
48phospholipid455.7LCAT, APOA1, APOC3, APOA2, APOB, SCARB1
49lipid455.1LIPC, APOB, ABCA1, PLTP, CETP, LDLR
50cholesterol45 29 11 248.1APOB, SCARB1, LPL, CRP, LDLR, CETP

GO Terms for genes affiliated with Hyperalphalipoproteinemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:0343639.8APOC3, APOB
2spherical high-density lipoprotein particleGO:0343669.7APOA1, APOA2, APOC3
3endocytic vesicle lumenGO:0716829.5APOB, APOA1
4low-density lipoprotein particleGO:0343629.5APOB, LDLR
5endoplasmic reticulum lumenGO:0057889.3APOB, APOA2, APOA1
6high-density lipoprotein particleGO:0343649.2LCAT, APOA1, APOA2, LIPC, CETP
7clathrin-coated endocytic vesicle membraneGO:0306699.2LDLR, APOB
8chylomicronGO:0426278.8APOC3, APOA2, APOB, LPL
9early endosomeGO:0057698.8APOA2, LDLR, APOB, APOA1, APOC3
10very-low-density lipoprotein particleGO:0343618.5APOA1, APOA2, APOB, LPL, APOC3
11extracellular regionGO:0055767.1PLTP, CRP, LPL, APOB, APOA2, APOC3
12extracellular spaceGO:0056156.8LCAT, APOA1, APOC3, APOB, LPL, CRP

Biological processes related to Hyperalphalipoproteinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cholesterol importGO:06062110.3APOA2, APOC3
2negative regulation of lipase activityGO:06019210.2APOA1, APOA2
3regulation of intestinal cholesterol absorptionGO:03030010.2APOA1, APOA2
4negative regulation of cytokine secretion involved in immune responseGO:00274010.2APOA1, APOA2
5chylomicron remnant clearanceGO:03438210.1APOC3, LIPC
6protein oxidationGO:01815810.1APOA1, APOA2
7peptidyl-methionine modificationGO:01820610.1APOA1, APOA2
8positive regulation of cholesterol esterificationGO:01087310.1APOA1, APOA2
9negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.0APOA2, APOC3, APOA1
10triglyceride mobilizationGO:00664210.0APOC3, APOB
11regulation of phosphatidylcholine catabolic processGO:01089910.0SCARB1, LDLR
12phosphatidylcholine biosynthetic processGO:0066569.9LCAT, APOA1, APOA2
13blood vessel endothelial cell migrationGO:0435349.9SCARB1, APOA1
14regulation of Cdc42 protein signal transductionGO:0324899.9ABCA1, APOC3, APOA1
15very-low-density lipoprotein particle assemblyGO:0343799.9APOB, APOC3
16high-density lipoprotein particle clearanceGO:0343849.9APOA1, APOA2, SCARB1
17high-density lipoprotein particle assemblyGO:0343809.8APOA1, APOA2, ABCA1
18lipoprotein catabolic processGO:0421599.8LDLR, APOB
19positive regulation of triglyceride biosynthetic processGO:0108679.8LDLR, SCARB1
20endothelial cell proliferationGO:0019359.8APOA1, SCARB1
21phospholipid transportGO:0159149.8CETP, SCARB1, LDLR
22lipoprotein biosynthetic processGO:0421589.7APOB, APOA1, LCAT
23cholesterol importGO:0705089.7APOA1, LDLR, SCARB1
24negative regulation of macrophage derived foam cell differentiationGO:0107459.7ABCA1, CRP, CETP
25negative regulation of lipid catabolic processGO:0509959.6APOA2, APOC3
26phospholipid catabolic processGO:0093959.6LIPG, APOA2
27phospholipid effluxGO:0337009.6APOA2, APOA1, APOC3, ABCA1
28lipoprotein transportGO:0429539.6APOB, APOC3
29receptor-mediated endocytosisGO:0068989.6CETP, LDLR, APOB
30response to nutrientGO:0075849.5LIPG, APOC3, APOA1
31low-density lipoprotein particle clearanceGO:0343839.5LDLR, SCARB1, APOB
32low-density lipoprotein particle remodelingGO:0343749.5APOA2, APOB, LIPC, CETP
33phospholipid homeostasisGO:0550919.3APOA1, LIPG, ABCA1, CETP
34triglyceride metabolic processGO:0066419.3APOC3, APOA2, CETP, LPL
35very-low-density lipoprotein particle remodelingGO:0343729.2CETP, LIPC, LPL, LCAT
36positive regulation of cholesterol storageGO:0108869.1SCARB1, APOB, LPL
37lipid metabolic processGO:0066299.1LDLR, PLTP, LIPG
38cholesterol transportGO:0303019.1LCAT, LDLR, APOB, CETP, APOA1
39response to drugGO:0424939.0APOA2, APOA1, APOC3, LPL
40triglyceride catabolic processGO:0194338.9APOB, LPL, LIPC, APOC3
41cholesterol effluxGO:0333448.7APOB, APOC3, APOA1, APOA2, ABCA1, SCARB1
42triglyceride homeostasisGO:0703288.6SCARB1, LIPC, APOC3, LPL, CETP, APOA1
43retinoid metabolic processGO:0015238.2APOA2, APOC3, APOA1, LPL, LDLR, APOB
44phototransduction, visible lightGO:0076038.2LPL, APOB, APOA2, APOC3, APOA1, LDLR
45high-density lipoprotein particle remodelingGO:0343758.2LIPG, CETP, SCARB1, APOA2, APOC3, LIPC
46cholesterol metabolic processGO:0082037.8LCAT, APOA1, APOC3, APOA2, APOB, LIPC
47reverse cholesterol transportGO:0436917.8APOA2, APOC3, SCARB1, LIPG, LIPC, CETP
48lipoprotein metabolic processGO:0421576.9APOA1, APOA2, APOB, LCAT, APOC3, SCARB1
49small molecule metabolic processGO:0442816.9APOA2, LDLR, CETP, ABCA1, LPL, LCAT
50cholesterol homeostasisGO:0426326.8LDLR, CETP, ABCA1, LIPC, LIPG, APOB

Molecular functions related to Hyperalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:03419010.0APOA1, APOA2
2lipid transporter activityGO:0053199.9CETP, APOA2
3high-density lipoprotein particle receptor bindingGO:0706539.9APOA1, APOC3, APOA2
4lipase inhibitor activityGO:0551029.9APOA2, APOC3, APOA1
5phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.9APOA2, APOA1
6phosphatidylcholine bindingGO:0312109.8APOA2, CETP
7phospholipid transporter activityGO:0055489.8ABCA1, CETP, APOA1
8high-density lipoprotein particle bindingGO:0080359.7SCARB1, APOA1, APOA2
9apolipoprotein A-I bindingGO:0341869.7ABCA1, SCARB1, LCAT
10triglyceride bindingGO:0171299.6LPL, CETP
11lipid bindingGO:0082899.4CETP, PLTP, APOA2
12low-density lipoprotein particle bindingGO:0301699.1SCARB1, CRP, LIPC, LDLR
13lipoprotein lipase activityGO:0044659.1LPL, LIPG
14cholesterol transporter activityGO:0171279.0CETP, ABCA1, APOB, APOA2, APOA1
15phospholipase activityGO:0046208.9LIPC, LIPG, LPL
16triglyceride lipase activityGO:0048068.9LIPG, LPL, LIPC
17phospholipid bindingGO:0055438.9ABCA1, APOB, APOC3, APOA1, APOA2
18apolipoprotein bindingGO:0341858.8SCARB1, LPL, LIPC, ABCA1
19cholesterol bindingGO:0154858.8APOC3, APOA1, APOA2, CRP, ABCA1, CETP
20heparin bindingGO:0082018.3APOB, LIPC, LIPG, LPL

Products for genes affiliated with Hyperalphalipoproteinemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperalphalipoproteinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet