MCID: HYP090
MIFTS: 52

Hyperalphalipoproteinemia malady

Categories: Genetic diseases, Metabolic diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Hyperalphalipoproteinemia

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Sources:
49OMIM, 11diseasecard, 47Novoseek, 24GTR, 51Orphanet, 65UMLS, 67UniProtKB/Swiss-Prot, 28ICD10 via Orphanet, 34MedGen, 36MeSH, 61The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Hyperalphalipoproteinemia:

Name: Hyperalphalipoproteinemia 49 11 47 24
Cholesteryl Ester Transfer Protein Deficiency 67 65
Familial Hyperalphalipoproteinemia 51 65
Hyperalphalipoproteinemia 1 67 65
 
Cholesterol-Ester Transfer Protein Deficiency 51
Cept Deficiency 51
Cetp Deficiency 67
Halp1 67

Characteristics:

HPO:

61
hyperalphalipoproteinemia:
Inheritance: autosomal dominant inheritance


Classifications:



External Ids:

OMIM49 143470
Orphanet51 79506
ICD10 via Orphanet28 E78.4
MeSH36 D006951
UMLS65 C0342883, C3149462, C3875011

Summaries for Hyperalphalipoproteinemia

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UniProtKB/Swiss-Prot:67 Hyperalphalipoproteinemia 1: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.

MalaCards based summary: Hyperalphalipoproteinemia, also known as cholesteryl ester transfer protein deficiency, is related to apolipoprotein c-iii deficiency and coronary artery disease, and has symptoms including hyperalphalipoproteinemia An important gene associated with Hyperalphalipoproteinemia is CETP (Cholesteryl Ester Transfer Protein), and among its related pathways are triacylglycerol degradation and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). Affiliated tissues include brain, lung and colon, and related mouse phenotypes are pigmentation and endocrine/exocrine gland.

Description from OMIM:49 143470

Related Diseases for Hyperalphalipoproteinemia

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Diseases in the Hyperalphalipoproteinemia family:

Cetp-Related Hyperalphalipoproteinemia

Diseases related to Hyperalphalipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1apolipoprotein c-iii deficiency27.9ABCA1, APOA1, APOA2, APOB, APOC3, CETP
2coronary artery disease25.0ABCA1, APOA1, APOA2, APOB, APOC3, APOE
3cetp-related hyperalphalipoproteinemia11.9
4spondylometaphyseal dysplasia, megarbane-dagher-melike type10.5LIPC, LPL
5amelogenesis imperfecta, type iia310.3APOA1, LIPC, LPL
6arsacs10.3APOE, LPL
7hereditary antithrombin deficiency10.3APOA1, APOA2
8amyloidosis beta2m10.3APOA1, LCAT
9retinal degeneration, late-onset, autosomal dominant10.3APOE, LPL
10pigmentary cirrhosis10.3APOE, PLTP
11hepatitis10.2
12alzheimer disease-210.2APOE, LCAT
13distal myopathy with posterior leg and anterior hand involvement10.2APOE, LPL
14spinocerebellar ataxia 410.2APOA1, APOA2, LCAT
15meckel syndrome 1010.1APOE, LDLR
16lipoprotein glomerulopathy10.1APOE, CETP
17metaphyseal dysplasia10.1APOA1, APOB
18lipid metabolism disorder10.0APOB, APOE
19legg-calve-perthes disease10.0APOA1, APOB
20heart disease10.0
21neuronal ceroid lipofuscinosis10.0APOB, LIPC, LPL
22extensor tendons of finger anomalies9.9ABCA1, APOA1, CETP
23arteriosclerosis9.9APOE, LDLR, PLTP
24hypoalphalipoproteinemia9.9
25hypertriglyceridemia9.9
26atherosclerosis9.9
27artery disease9.9
28multiple symmetric lipomatosis9.9
29multiple symmetrical lipomatosis9.9
30lipomatosis9.9
31carnitine deficiency, systemic primary9.8APOA1, APOB
32multiple epiphyseal dysplasia9.8APOA1, APOB, APOE
33carotid artery thrombosis9.8APOA1, APOB, APOE
34colonic benign neoplasm9.7APOA1, APOB, APOE
35hypercholesterolemia, due to ligand-defective apo b9.6APOB, APOE, LDLR
36porencephaly9.6APOA1, APOB, APOE, CETP
37conjunctivochalasis9.6APOA1, APOB, APOE, CETP
38hepatitis c virus9.5APOE, LDLR, SCARB1
39ischemic optic neuropathy9.5APOA1, APOB, APOE, LPL
40hypobetalipoproteinemia9.4APOB, LDLR
41hemochromatosis, type 59.4ABCA1, APOE, LDLR
42bacteriuria9.3APOA2, APOB, LCAT, LIPC, LPL
43spleen cancer9.3APOA1, APOB, APOE, LDLR
44mesenchymal cell neoplasm9.3APOB, APOE, LDLR, LPL
45deficiency of n-glycanase 19.3APOB, APOE, LCAT, LDLR
46hepatic adenoma, somatic9.2APOA1, APOB, APOC3, CETP, LIPC, LPL
47arteriovenous fistula9.1ABCA1, APOE, CETP, LIPC, LPL
48macular degeneration, age-related, 19.0ABCA1, APOB, APOE, LIPC
49wolfram syndrome 28.9APOA1, APOB, APOE, CETP, LCAT, LPL
50thyroid cancer8.8APOA1, APOB, APOE, CETP, LDLR, LPL

Graphical network of the top 20 diseases related to Hyperalphalipoproteinemia:



Diseases related to hyperalphalipoproteinemia

Symptoms for Hyperalphalipoproteinemia

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Symptoms by clinical synopsis from OMIM:

143470

Clinical features from OMIM:

143470

HPO human phenotypes related to Hyperalphalipoproteinemia:

id Description Frequency HPO Source Accession
1 hyperalphalipoproteinemia HP:0012184

Drugs & Therapeutics for Hyperalphalipoproteinemia

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Drugs for Hyperalphalipoproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Adenosineapproved, investigational36358-61-760961
Synonyms:
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
1odi
2fqy
2gl0
30143-02-3
4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside
46946-45-6
46969-16-8
58-61-7
6-Amino-9-.beta.-ribofuranosyl-9H-purine
6-Amino-9-beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-delta-ribofuranosyl-9H-purine
9-(beta-D-Arabinofuranosyl)adenine
9-beta-D-Arabinofuranosyladenine
9-beta-D-Ribofuranosidoadenine
9-beta-D-Ribofuranosyl-9H-purin-6-amine
9-beta-D-Ribofuranosyladenine
9-beta-delta-Arabinofuranosyladenine
9-beta-delta-Ribofuranosidoadenine
9-beta-delta-Ribofuranosyl-9H-purin-6-amine
9-beta-delta-Ribofuranosyladenine
9beta-D-Ribofuranosyladenine
9beta-D-ribofuranosyl-9H-Purin-6-amine
9beta-delta-Ribofuranosyladenine
9beta-delta-ribofuranosyl-9H-Purin-6-amine
A0152
A4036_SIGMA
A9251_SIGMA
AC1L1U8O
AC1Q1ID3
AC1Q52XU
ADN
AI3-52413
Ade-Rib
Ade-rib
Adenin riboside
Adenine 9-beta-D-arabinofuranoside
Adenine deoxyribonucleoside
Adenine nucleoside
Adenine riboside
Adenine-9-beta-D-ribofuranoside
Adenine-9beta-D-Ribofuranoside
Adenine-9beta-delta-Ribofuranoside
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosina
Adenosine
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine, homopolymer
Adenosinum
Adensoine
Adenyldeoxyriboside
Ado
Adénosine
BB_NC-0565
BSPBio_001796
Bio1_000437
 
Bio1_000926
Bio1_001415
Boniton
C00212
CCRIS 2557
CHEBI:16335
CHEMBL477
CID60961
Caswell No. 010B
D000241
D00045
DB00640
Deoxyadenosine
Desoxyadenosine
EA6C60C2-6AFB-4264-A2F0-541373DB950E
EINECS 200-389-9
FT-0082881
HMS1920A13
HMS2091G13
KBio3_001296
LS-15085
MEDR-640
MLS000069638
MLS002153227
MolPort-001-838-229
Myocol
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NSC 627048
NSC 7652
NSC627048
NSC7652
Nucleocardyl
Pallacor
Polyadenosine
Polyriboadenosine
S1647_Selleck
SDCCGMLS-0003108.P003
SMR000058216
SPBio_001194
SPECTRUM1500107
SR 96225
SR-96225
SUN-Y4001
Sandesin
Spectrum2_001257
Spectrum3_000288
TL8003749
UNII-K72T3FS567
USAF CB-10
V0098
Vidarabine
ZINC02169830
adenine-D-ribose
adenosine
b-D-Adenosine
beta-Adenosine
beta-D-Adenosine
beta-D-Ribofuranoside, adenine-9
beta-delta-Adenosine
bmse000061
nchembio.143-comp9
nchembio.186-comp109
nchembio.2007.56-comp13
nchembio.64-comp4
nchembio706-5
2Pharmaceutical Solutions7004

Interventional clinical trials:

idNameStatusNCT IDPhase
1Relationship Between CETP Deficiency and Atherosclerosis in Patients With HyperalphalipoproteinemiaRecruitingNCT01916512
2Genes Involved in Lipid DisordersRecruitingNCT02311335
3Causes and Natural History of DyslipidemiasRecruitingNCT00353782
4Mendelian Reverse Cholesterol Transport StudyRecruitingNCT01782027

Search NIH Clinical Center for Hyperalphalipoproteinemia

Genetic Tests for Hyperalphalipoproteinemia

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Anatomical Context for Hyperalphalipoproteinemia

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MalaCards organs/tissues related to Hyperalphalipoproteinemia:

33
Brain, Lung, Colon, Prostate, Thymus, T cells, Testes

Animal Models for Hyperalphalipoproteinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperalphalipoproteinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.2ABCA1, APOB, APOE, LDLR
2MP:00053797.6ABCA1, APOA1, APOE, LCAT, LDLR, LIPC
3MP:00053917.6ABCA1, APOB, APOE, LCAT, LDLR, PLTP
4MP:00053706.9ABCA1, APOA1, APOB, APOE, LCAT, LDLR
5MP:00053856.2ABCA1, APOA1, APOB, APOE, LCAT, LDLR
6MP:00053764.9ABCA1, APOA1, APOA2, APOB, APOE, LCAT

Publications for Hyperalphalipoproteinemia

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Articles related to Hyperalphalipoproteinemia:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Improved plasma cholesterol efflux capacity from human macrophages in patients with hyperalphalipoproteinemia. (24674903)
2014
2
Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia. (23219720)
2013
3
Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia. (22464213)
2012
4
Novel mutations of CETP gene in Italian subjects with hyperalphalipoproteinemia. (18926541)
2009
5
Two novel mutations and functional analyses of the CETP and LIPC genes underlying severe hyperalphalipoproteinemia. (19428034)
2009
6
Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations. (18160998)
2008
7
Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia. (19013296)
2008
8
Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians. (17192423)
2007
9
The two novel CETP mutations Gln87X and Gln165X in a compound heterozygous state are associated with marked hyperalphalipoproteinemia and absence of significant coronary artery disease. (16855848)
2006
10
Cholesteryl ester transfer protein gene mutations in Brazilian hyperalphalipoproteinemia. (16650090)
2006
11
Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical properties. (14739123)
2004
12
Prevalence and phenotypic spectrum of cholesteryl ester transfer protein gene mutations in Japanese hyperalphalipoproteinemia. (12482565)
2003
13
Distribution of human plasma PLTP mass and activity in hypo- and hyperalphalipoproteinemia. (12177167)
2002
14
A novel mutation in the intron 1 splice donor site of the cholesterol ester transfer protein (CETP) gene as a cause of hyperalphalipoproteinemia. (11887180)
2002
15
The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice. (10669644)
2000
16
Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia. (10998455)
2000
17
Elevated hepatic apolipoprotein A-I transcription is associated with diet-induced hyperalphalipoproteinemia in rabbits. (10809165)
2000
18
Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. (10606208)
1999
19
Hyperalphalipoproteinemia: characterization of a cardioprotective profile associating increased high-density lipoprotein2 levels and decreased hepatic lipase activity. (9711993)
1998
20
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. (9555865)
1998
21
Upregulated synthesis of both apolipoprotein A-I and apolipoprotein B in familial hyperalphalipoproteinemia and hyperbetalipoproteinemia. (9751249)
1998
22
Hyperalphalipoproteinemia and prostaglandin I2 stability. (9336872)
1997
23
Serum apolipoprotein E-rich HDL-C levels in the subjects with hyperalphalipoproteinemia]. (9311266)
1997
24
Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. (9194754)
1997
25
Cholesteryl ester transfer protein (CETP) deficiency and increased HDL cholesterol levels (hyperalphalipoproteinemia)]. (8847813)
1996
26
Atherosclerotic disease in marked hyperalphalipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. (7583564)
1995
27
Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. (7744879)
1995
28
Unsaturated fatty acids incorporated in HDL in hypo- and hyperalphalipoproteinemia--relation to the HDL-cholesterol level. (7778503)
1994
29
Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia. (8231838)
1993
30
Frequency of intron 14 splicing defect of cholesteryl ester transfer protein gene in the Japanese general population--relation between the mutation and hyperalphalipoproteinemia. (8318066)
1993
31
Rapid detection and prevalence of cholesteryl ester transfer protein deficiency caused by an intron 14 splicing defect in hyperalphalipoproteinemia. (8454281)
1993
32
Compound heterozygote of cholesteryl-ester transfer protein deficiency in a patient with hyperalphalipoproteinemia. (1418105)
1992
33
Association of a polymorphism in the Apo AI gene promoter with hyperalphalipoproteinemia. (1505654)
1992
34
Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. (2022742)
1991
35
A family of homozygous familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity. (2360880)
1990
36
Human apolipoprotein A-I gene promoter polymorphism: association with hyperalphalipoproteinemia. (1980685)
1990
37
High density lipoprotein metabolism in a rabbit model of hyperalphalipoproteinemia. (2920068)
1989
38
Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia. (2504859)
1989
39
Small polydisperse low density lipoproteins in familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity. (3355618)
1988
40
Decreased serum cholesteryl-ester transfer activity in a patient with familial hyperalphalipoproteinemia. (3193660)
1988
41
Type II hyperlipoproteinemia, hyperapobetalipoproteinemia, and hyperalphalipoproteinemia following renal transplantation: implications for atherogenic risk. (3303510)
1987
42
High density lipoproteins with poor reactivity to cholesteryl ester transfer reaction observed in a homozygote of familial hyperalphalipoproteinemia. (3789924)
1986
43
A pedigree of homozygous familial hyperalphalipoproteinemia. (6738363)
1984
44
Metabolic abnormalities in multiple symmetric lipomatosis: elevated lipoprotein lipase activity in adipose tissue with hyperalphalipoproteinemia. (6875381)
1983
45
Complex segregation analysis of hyperalphalipoproteinemia. (7078431)
1982
46
Hyperalphalipoproteinemia, birth to age to years. (7208170)
1981
47
Hyperalphalipoproteinemia in hypercholesterolemic adults and children. (7245576)
1980
48
Neonatal familial hyperalphalipoproteinemia. (191726)
1977
49
Composition of HDL-2 and HDL-3 in familial hyperalphalipoproteinemia. (186077)
1976
50
Familial hyperalphalipoproteinemia. (168823)
1975

Variations for Hyperalphalipoproteinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hyperalphalipoproteinemia:

67
id Symbol AA change Variation ID SNP ID
1CETPp.Asp459GlyVAR_004172rs2303790
2CETPp.Leu168ProVAR_033099
3CETPp.Arg299CysVAR_033100

Clinvar genetic disease variations for Hyperalphalipoproteinemia:

5
id Gene Variation Type Significance SNP ID Assembly Location
1CETPCETP, IVS14DS, G-A, +1single nucleotide variantPathogenic
2CETPNM_000078.2(CETP): c.1376A> G (p.Asp459Gly)single nucleotide variantPathogenicrs2303790GRCh37Chr 16, 57017292: 57017292
3CETPCETP, 1-BP INS, T, IVS14, +3insertionPathogenic

Expression for genes affiliated with Hyperalphalipoproteinemia

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Search GEO for disease gene expression data for Hyperalphalipoproteinemia.

Pathways for genes affiliated with Hyperalphalipoproteinemia

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Pathways related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.7LIPC, LIPG
29.6ABCA1, CETP
39.4ABCA1, LDLR
49.3APOA1, APOB, SCARB1
5
Show member pathways
9.3LDLR, LPL, SCARB1
6
Show member pathways
9.3LIPC, LIPG, LPL
79.2APOE, LDLR
89.2ABCA1, APOA1, APOA2
9
Show member pathways
8.9APOA1, APOA2, APOC3, LPL, PLTP
108.7ABCA1, APOA1, APOB, SCARB1
11
Show member pathways
8.5APOA1, APOB, APOE, SCARB1
12
Show member pathways
8.4ABCA1, APOA1, APOE, SCARB1
13
Show member pathways
8.3ABCA1, APOA1, APOB, LDLR, SCARB1
14
Show member pathways
7.3APOA1, APOA2, APOB, APOC3, APOE, LDLR
15
Show member pathways
7.3APOA1, APOA2, APOB, APOC3, APOE, LDLR
16
Show member pathways
5.3ABCA1, APOA1, APOA2, APOB, APOC3, APOE
17
Show member pathways
4.7ABCA1, APOA1, APOA2, APOB, APOC3, APOE
18
Show member pathways
4.7ABCA1, APOA1, APOA2, APOB, APOC3, APOE

GO Terms for genes affiliated with Hyperalphalipoproteinemia

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Cellular components related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:003436310.2APOB, APOC3
2clathrin-coated endocytic vesicle membraneGO:003066910.0APOB, LDLR
3Golgi apparatusGO:00057949.2APOB, LDLR
4early endosomeGO:00057698.2APOA1, APOA2, APOB, APOC3, APOE

Biological processes related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1blood vessel endothelial cell migrationGO:004353410.5APOA1, SCARB1
2phosphatidylcholine metabolic processGO:004647010.5CETP, LCAT
3peptidyl-methionine modificationGO:001820610.5APOA1, APOA2
4chylomicron remodelingGO:003437110.4LIPC, LPL
5cholesterol importGO:007050810.4APOA1, LDLR
6very-low-density lipoprotein particle assemblyGO:003437910.3APOB, APOC3
7organ regenerationGO:003110010.3APOA1, APOA2
8protein oxidationGO:001815810.3APOA1, APOA2
9phospholipid catabolic processGO:000939510.2APOA2, LIPG
10positive regulation of macrophage derived foam cell differentiationGO:001074410.1APOB, LPL
11lipid catabolic processGO:001604210.1APOB, LPL
12regulation of Cdc42 protein signal transductionGO:003248910.1APOC3, APOE
13viral entry into host cellGO:004671810.1LDLR, SCARB1
14chylomicron remnant clearanceGO:003438210.0APOE, LIPC
15neuron projection regenerationGO:003110210.0APOA1, APOE
16very-low-density lipoprotein particle remodelingGO:003437210.0APOE, CETP
17cholesterol catabolic processGO:000670710.0APOE, SCARB1
18phosphatidylcholine biosynthetic processGO:000665610.0APOA1, APOA2, LCAT
19triglyceride homeostasisGO:00703289.7APOA1, CETP, LPL, SCARB1
20high-density lipoprotein particle assemblyGO:00343809.7ABCA1, APOE
21response to nutrientGO:00075849.7ABCA1, APOA1, APOC3
22lipoprotein metabolic processGO:00421579.6ABCA1, APOC3, LPL
23positive regulation of cholesterol esterificationGO:00108739.6APOA1, APOA2, APOE
24lipoprotein biosynthetic processGO:00421589.6APOA1, APOA2, APOE
25low-density lipoprotein particle clearanceGO:00343839.6APOB, LIPC, SCARB1
26low-density lipoprotein particle remodelingGO:00343749.4APOA2, APOB, APOE
27phospholipid homeostasisGO:00550919.4ABCA1, APOA1, CETP, LIPG
28phospholipid transportGO:00159149.4ABCA1, CETP, LDLR, SCARB1
29receptor-mediated endocytosisGO:00068989.4APOA1, APOE, CETP
30phospholipid effluxGO:00337009.4APOA1, APOA2, APOC3, APOE
31lipoprotein catabolic processGO:00421599.3APOB, APOE, LDLR
32response to drugGO:00424939.3APOA1, APOA2, APOC3, LIPC
33cholesterol metabolic processGO:00082039.2APOB, APOE, LDLR
34triglyceride catabolic processGO:00194339.1APOB, APOC3, APOE, LPL
35cholesterol transportGO:00303019.0ABCA1, APOA2, CETP, LCAT, LIPC
36triglyceride metabolic processGO:00066419.0APOA2, APOC3, APOE, CETP, LIPC
37high-density lipoprotein particle remodelingGO:00343758.9APOA1, APOA2, APOC3, CETP, LCAT, LIPC
38retinoid metabolic processGO:00015238.6APOA1, APOB, APOC3, APOE, LPL
39lipid metabolic processGO:00066298.4APOB, APOE, LCAT, LIPC, LPL
40lipid transportGO:00068698.1APOA2, APOB, APOC3, APOE, CETP, PLTP
41phototransduction, visible lightGO:00076038.1APOA1, APOA2, APOB, APOC3, APOE, LPL
42cholesterol effluxGO:00333448.0ABCA1, APOA1, APOA2, APOB, APOE, SCARB1
43small molecule metabolic processGO:00442817.9ABCA1, APOA1, APOA2, APOC3, LCAT, LIPC
44reverse cholesterol transportGO:00436917.6ABCA1, APOA1, APOA2, APOC3, APOE, LCAT
45cholesterol homeostasisGO:00426327.0ABCA1, APOA2, APOC3, APOE, LDLR, LIPC

Molecular functions related to Hyperalphalipoproteinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle bindingGO:000803510.1APOA1, APOA2
2lipid bindingGO:000828910.0CETP, LIPC
3high-density lipoprotein particle receptor bindingGO:00706539.8APOA1, APOA2, APOC3
4heparin bindingGO:00082019.2LIPC, LIPG, LPL

Sources for Hyperalphalipoproteinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet