MCID: HYP043
MIFTS: 54

Hyperandrogenism malady

Summaries for Hyperandrogenism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive production... more...

MalaCards: Hyperandrogenism, also known as hyperandrogenization syndrome, is related to polycystic ovary syndrome and obesity. An important gene associated with Hyperandrogenism is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cytochrome P450 - arranged by substrate type and Endogenous sterols. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Hyperandrogenism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

hyperandrogenism 8 10 44 60
hyperandrogenization syndrome 8


External Ids:

Disease Ontology8 DOID:11613
SNOMED-CT56 237793004
MeSH34 D017588

Related Diseases for Hyperandrogenism

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17GeneCards, 18GeneDecks
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Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.3SHBG, IGFBP1, POMC, CYP17A1, CYP21A2, CYP11A1
2obesity31.0CYP11A1, MC4R, RETN, INS, INSL3, SRD5A1
3acanthosis nigricans30.8SHBG, CYP21A2, INS
4anovulation30.7INS, CYP21A2, IGFBP1, SHBG, GNRH1, SRD5A1
5hyperinsulinism30.6GNRH1, LSL, SHBG, IGFBP1, INS, RETN
6acne30.5SHBG
7amenorrhea30.4INS, POMC, SHBG, GNRH1
8diabetes mellitus30.4CAPN10, LSL, SHBG, IGFBP1, POMC, MC4R
9infertility30.4GNRH1, SHBG, IGFBP1, CYP21A2, CYP11A1, RETN
10congenital adrenal hyperplasia30.4GNRH1, POMC, CYP17A1, CYP21A2, CYP11A1, SRD5A1
11alopecia30.3SHBG
12ovarian disease30.3GNRH1, SHBG, IGFBP1
13leydig cell tumor30.2HSD3BP4, LHCGR, GNRH1, CGB5, POMC, CYP17A1
14androgenic alopecia30.1SRD5A1, CYP21A2, SHBG
15hypertension30.1POMC, CYP17A1, RETN, INS
16hyperprolactinemia30.1GNRH1, CGB5, SHBG, POMC, SRD5A1
17adrenal adenoma30.1HSD3BP4, POMC, CYP17A1, CYP21A2, CYP11A1
18prostatitis30.0SRD5A1
19hepatitis30.0IGFBP1
20ovarian cancer30.0LHCGR, GNRH1, CGB5, CYP17A1
21glucose intolerance30.0CAPN10, LSL, SHBG, IGFBP1, RETN, INS
22adenoma30.0HSD3BP4, LHCGR, GNRH1, SHBG, IGFBP1, POMC
23cushing's syndrome29.8CYP21A2, INS, POMC
24laron syndrome29.8IGFBP1
25hyperthyroidism29.8LSL, CGB5, SHBG, RETN, INS, SRD5A1
26colorectal cancer29.8CYP17A1
27acromegaly29.8LSL, GNRH1, SHBG, IGFBP1, POMC, RETN
28hyperglycemia29.8LSL, IGFBP1, POMC, RETN, INS
29breast cancer29.8LHCGR, GNRH1, SHBG, IGFBP1, CYP17A1, CYP21A2
30atherosclerosis29.8CAPN10, LSL, SHBG, RETN, INS
31schizophrenia29.8INS
3221-hydroxylase deficiency10.3
33mullerian aplasia and hyperandrogenism10.2
34type 1 diabetes mellitus10.1
35hair-an syndrome10.1
36biliary atresia10.0
37adult syndrome10.0
38hemangioma10.0
39cortisone reductase deficiency 110.0
40thyroiditis10.0POMC
41hypogonadotropism10.0GNRH1
42graves' disease10.0CYP21A2, SHBG
43blindness10.0INS
44pseudohermaphroditism10.0HSD3B2, LHCGR, CYP17A1
45ovarian hyperstimulation syndrome10.0GNRH1, CGB5
46hypoadrenalism10.0POMC
47prolactinoma10.0POMC, GNRH1
48diabetes insipidus10.0POMC
49hyperaldosteronism10.0CYP21A2, CYP17A1, POMC
50essential hypertension10.0INS, RETN, SHBG

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to hyperandrogenism

Clinical Features for Hyperandrogenism

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Drugs & Therapeutics for Hyperandrogenism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperandrogenism

Drug clinical trials:

Search ClinicalTrials for Hyperandrogenism

Search NIH Clinical Center for Hyperandrogenism

Search CenterWatch for Hyperandrogenism

Genetic Tests for Hyperandrogenism

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Anatomical Context for Hyperandrogenism

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32MalaCards
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MalaCards organs/tissues related to Hyperandrogenism:

32
Ovary, Testes, Bone, Pituitary, Skin, Heart, Prostate, Adipocyte, Breast, Cortex, Endothelial, Adrenal cortex

Animal Models for Hyperandrogenism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperandrogenism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.5SRD5A1, CYP11A1, CAPN10, LHCGR
2MP:000536710.3CAPN10, GNRH1, POMC, INS, WNT4, LHCGR
3MP:000538910.3LHCGR, GNRH1, CYP17A1, CYP11A1, MC4R, INS
4MP:000537010.3CAPN10, GNRH1, IGFBP1, POMC, MC4R, RETN
5MP:000537510.2LHCGR, CAPN10, POMC, MC4R, RETN, INS
6MP:000538710.0LHCGR, CAPN10, GNRH1, IGFBP1, POMC, CYP11A1

Publications for Hyperandrogenism

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50PubMed
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Articles related to Hyperandrogenism:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
The new policy on hyperandrogenism in elite female athletes is not about "sex testing". (23320653)
2013
2
Hyperprolactinemia and hyperandrogenism in an adolescent girl presenting with primary amenorrhea. (23182426)
2013
3
In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone. (23845740)
2013
4
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
5
New standards, same refrain: the IAAF's regulations on hyperandrogenism. (22694031)
2012
6
Heterozygous 21-hydroxylasedeficiency as a cause of hyperandrogenism. (22925435)
2012
7
Hyperandrogenism in women with polycystic ovary syndrome persists after menopause. (21177795)
2011
8
Defining hyperandrogenism in polycystic ovary syndrome: measurement of testosterone and androstenedione by liquid chromatography-tandem mass spectrometry and analysis by receiver operator characteristic plots. (20008514)
2010
9
Effects of two estroprogestins containing ethynilestradiol 30 microg and drospirenone 3 mg and ethynilestradiol 30 microg and chlormadinone 2 mg on skin and hormonal hyperandrogenic manifestations. (19172543)
2008
10
Low-dose glucocorticoids in hyperandrogenism. (17628912)
2007
11
Low leptin level in an obese hyperandrogenic woman--potential marker for androgen-secreting tumor. (17454162)
2007
12
Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. (16263820)
2006
13
Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in nonobese adolescents and women. (16798281)
2006
14
Androgen excess disorders in women: the severe insulin-resistant hyperandrogenic syndrome, HAIR-AN. (16435040)
2006
15
Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome. (16551740)
2006
16
Gene analysis of steroid 5 alpha-reductase 1 in hyperandrogenic women. (16100771)
2005
17
The relationships between testosterone, body composition, and insulin resistance: a lesson from a case of extreme hyperandrogenism. (15677808)
2005
18
Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of metformin at the start and after more than one year of therapy. (15483105)
2005
19
Serum anti-Mullerian hormone levels during controlled ovarian hyperstimulation in women with polycystic ovaries with and without hyperandrogenism. (15802320)
2005
20
Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. (12917504)
2003
21
Frequency of the T228A polymorphism in the SORBS1 gene in children with premature pubarche and in adolescent girls with hyperandrogenism. (12849814)
2003
22
Correction of insulin resistance and hyperandrogenism in polycystic ovary syndrome by combined rosiglitazone and clomiphene citrate therapy. (12593999)
2003
23
Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism. (12091857)
2002
24
Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women. (11937112)
2002
25
The relationship between ovarian structure and hyperandrogenism in premature pubarche. (11308043)
2001
26
Two hyperandrogenic adolescent girls with congenital portosystemic shunt. (11388600)
2001
27
Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide. (10999817)
2000
28
New treatments of hyperandrogenism and hirsutism. (10958004)
2000
29
Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome. (9509072)
1998
30
Hyperandrogenic anovulation (the polycystic ovary syndrome)--back to the ovary? (9741712)
1998
31
Abnormalities in the serum insulin-like growth factor-1 axis in women with hyperandrogenism. (9848301)
1998
32
Estimated prevalence of undiagnosed glucose intolerance from hyperandrogenic anovulation among women requesting electrolysis. (9309459)
1997
33
Resistance of gonadotropin releasing hormone drive to sex steroid-induced suppression in hyperandrogenic anovulation. (9398736)
1997
34
Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism. (8772605)
1996
35
Ultrasound assessment of ovarian stroma hypertrophy in hyperandrogenism and ovulation disorders: visual analysis versus computerized quantification. (7615108)
1995
36
Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. (7650669)
1995
37
Effect of systemic hyperandrogenism on the adrenal response to ACTH. (7926131)
1994
38
Clinical and endocrine effects of flutamide in hyperandrogenic women. (8224265)
1993
39
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. (8413434)
1993
40
Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. (8501168)
1993
41
The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. (8222298)
1993
42
11 beta-hydroxylase deficiency in hyperandrogenism. (2009997)
1991
43
Selective venous catheterization in the evaluation of hyperandrogenism. (1806613)
1991
44
Hyperandrogenism in peripubertal girls. (2259543)
1990
45
Ovine corticotropin-releasing factor and dexamethasone responses in hyperandrogenic women. (2165925)
1990
46
A syndrome of hyperandrogenism, insulin resistance, and acanthosis nigricans associated with polycystic ovary syndrome: clinical and laboratory features. (2095357)
1990
47
Polycystic ovary syndrome: obesity, insulin resistance, hyperandrogenism. (2700062)
1989
48
The consequences of hyperandrogenism in young women. (20894691)
1988
49
Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the type A and B syndromes. (3881301)
1985
50
Investigative strategy of hyperandrogenism in women. (6224728)
1983

Genetic Variations for Hyperandrogenism

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Expression for genes affiliated with Hyperandrogenism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperandrogenism

Search GEO for disease gene expression data for Hyperandrogenism.

Pathways for genes affiliated with Hyperandrogenism

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Hyperandrogenism

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Hyperandrogenism according to GeneCards/GeneDecks:

(show top 50)    (show all 161)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9SRD5A1
2forskolin44 49 1112.7RETN, LHCGR, CYP17A1, POMC
3doca4410.7CYP11A1, HSD3BP4, CYP21A2, CYP17A1, POMC, SRD5A1
4clomiphene citrate4410.7GNRH1, CGB5, IGFBP1, CYP21A2, INS, SHBG
517-hydroxypregnenolone4410.7CYP21A2, CYP17A1, POMC, IGFBP1, SHBG, CGB5
6Pregnenolone11 2411.7HSD3B2, CYP17A1, CYP21A2, CYP11A1
7corticosterone44 59 2412.7LHCGR, MC4R, CYP11A1, CYP21A2, POMC, IGFBP1
8metformin44 49 1112.7LSL, GNRH1, SHBG, IGFBP1, POMC, CYP17A1
9ketoconazole44 28 11 2413.7SRD5A1, CYP11A1, CYP21A2, CYP17A1, POMC, SHBG
1011beta-hydroxysteroid4410.7POMC, CGB5, HSD3BP4, HSD3B2, CYP17A1, CYP21A2
11leuprolide acetate4410.7SHBG, LHCGR, GNRH1, CYP21A2, CGB5
12norepinephrine44 11 2412.7CYP21A2, POMC, CGB5, GNRH1, RETN
1317beta-hydroxysteroid4410.7SRD5A1, CYP11A1, HSD3B2, CGB5, CYP17A1, CYP21A2
14goserelin44 28 1112.7SRD5A1, GNRH1, LSL, SHBG, LHCGR
15progestin4410.7HSD3BP4, LHCGR, GNRH1, CGB5, SHBG, IGFBP1
16dihydrotestosterone44 28 11 2413.7HSD3B2, IGFBP1, GNRH1, CGB5, CYP17A1, CYP21A2
17acth 1-244410.7POMC, CYP17A1, CYP21A2, CYP11A1
18spironolactone49 44 59 28 1114.7SRD5A1, GNRH1, POMC, SHBG, CYP21A2
193beta-hydroxysteroid4410.7CGB5, LHCGR, HSD3BP4, HSD3B2, POMC, CYP17A1
20c-peptide4410.6IGFBP1, SHBG, LSL, CYP21A2, INS, RETN
21estrone44 28 11 2413.6CYP17A1, SHBG, LSL, GNRH1, CGB5, SRD5A1
22thyroxine44 2411.6RETN, CYP21A2, POMC, IGFBP1, GNRH1, INS
23acth4410.6CYP21A2, CYP17A1, POMC, IGFBP1, CGB5, GNRH1
24ribonucleic acid4410.6CYP17A1, IGFBP1, CGB5, CYP21A2, CYP11A1, POMC
25gnrh4410.6CGB5, SHBG, IGFBP1, POMC, CYP17A1, CYP21A2
26cholesterol44 28 11 2413.6HSD3B2, HSD3BP4, LHCGR, CAPN10, LSL, SHBG
27epinephrine44 11 2412.6INS, GNRH1, CYP21A2, POMC, CGB5, SHBG
2817-hydroxyprogesterone44 2411.6POMC, IGFBP1, SHBG, CGB5, GNRH1, HSD3BP4
29dehydroepiandrosterone sulfate4410.6HSD3B2, HSD3BP4, LSL, GNRH1, SHBG, CGB5
30dhea4410.6SRD5A1, INS, RETN, CYP11A1, CYP21A2, CYP17A1
31androstenedione44 2411.6SRD5A1, INS, CYP11A1, CYP21A2, CYP17A1, POMC
32mifepristone44 59 28 1113.6HSD3BP4, IGFBP1, POMC, SHBG, CGB5, GNRH1
33alanine4410.6MC4R, SHBG, LSL, LHCGR, INSL3, INS
34arginine4410.6IGFBP1, SHBG, LSL, GNRH1, POMC, CYP17A1
35leuprolide44 59 28 1113.6GNRH1, LSL, SRD5A1, CGB5
36dexamethasone44 49 28 1113.6HSD3BP4, LSL, GNRH1, CGB5, SHBG, IGFBP1
37hydrocortisone44 2 59 1113.6IGFBP1, LSL, SHBG, POMC, CYP21A2, INS
38estradiol44 11 2412.6GNRH1, POMC, CYP17A1, CYP21A2, CYP11A1, RETN
39diethylstilbestrol44 28 1112.5GNRH1, CGB5, CYP17A1, INSL3, SHBG
40progesterone44 59 28 11 2414.5HSD3BP4, SRD5A1, LHCGR, LSL, GNRH1, CGB5
41steroid4410.5SHBG, INSL3, IGFBP1, POMC, CYP17A1, CYP21A2
42glucose4410.5CYP21A2, LSL, CGB5, POMC
43testosterone44 59 11 2413.5IGFBP1, POMC, CYP17A1, CYP21A2, CYP11A1, RETN
4411 deoxycortisol4410.5SHBG, POMC, CYP17A1, CYP21A2
45rosiglitazone44 49 28 11 2414.5IGFBP1, CYP17A1, SHBG, LSL, RETN, INS
46lipid4410.5CYP17A1, CYP21A2, CYP11A1, MC4R, RETN, SHBG
47valproate4410.4CYP11A1, CYP17A1, IGFBP1, LSL, SHBG
48dihydroprogesterone4410.4HSD3BP4, SRD5A1, CYP11A1, CGB5
49allopregnanolone4410.3SHBG, POMC, GNRH1, SRD5A1
50aminoglutethimide44 1111.1CYP11A1, CYP21A2, POMC, CGB5

GO Terms for genes affiliated with Hyperandrogenism

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16Gene Ontology
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Cellular components related to Hyperandrogenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.4INS, POMC
2extracellular regionGO:00557610.2WNT4, GNRH1, SHBG, IGFL3, IGFBP1, POMC
3extracellular spaceGO:00561510.0GNRH1, IGFBP1, POMC, RETN, INS, INSL3

Biological processes related to Hyperandrogenism according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00670410.7CYP21A2, CYP17A1, HSD3B2
2sterol metabolic processGO:01612510.7CYP17A1, CYP21A2, CYP11A1
3negative regulation of feeding behaviorGO:200025210.7MC4R, INS
4androgen biosynthetic processGO:00670210.7SRD5A1, WNT4, CYP17A1, HSD3B2
5response to fungicideGO:06099210.7CYP17A1, CYP11A1
6steroid metabolic processGO:00820210.7HSD3B2, CYP17A1, CYP21A2, CYP11A1, SRD5A1
7dibenzo-p-dioxin metabolic processGO:01889410.7CYP17A1, CYP11A1
8biphenyl metabolic processGO:01887910.7CYP17A1, CYP11A1
9cell-cell signalingGO:00726710.6WNT4, INSL3, INS, POMC, GNRH1
10response to insecticideGO:01708510.6CYP17A1, CYP11A1
11phthalate metabolic processGO:01896310.6CYP17A1, CYP11A1
12phenol-containing compound metabolic processGO:01895810.6CYP17A1, CYP11A1
13mineralocorticoid biosynthetic processGO:00670510.6HSD3B2, CYP21A2
14cellular response to antibioticGO:07123610.5CYP17A1, CYP11A1
15sex differentiationGO:00754810.4SRD5A1, CYP17A1
16male gonad developmentGO:00858410.4WNT4, INSL3, LHCGR
17cellular response to gonadotropin stimulusGO:07137110.3LHCGR, CYP17A1
18Leydig cell differentiationGO:03332710.1CYP11A1, CYP17A1

Molecular functions related to Hyperandrogenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:00905510.4SRD5A1, CYP11A1, CYP21A2, CYP17A1
2hormone activityGO:00517910.1INSL3, INS, RETN, POMC, GNRH1

Products for genes affiliated with Hyperandrogenism

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  • Antibodies
  • Proteins
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Sources for Hyperandrogenism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet