MCID: HYP043
MIFTS: 54

Hyperandrogenism malady

Summaries for Hyperandrogenism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive production... more...

MalaCards: Hyperandrogenism, also known as hyperandrogenization syndrome, is related to polycystic ovary syndrome and obesity. An important gene associated with Hyperandrogenism is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cytochrome P450 - arranged by substrate type and Endogenous sterols. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Hyperandrogenism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

hyperandrogenism 8 10 44 60
hyperandrogenization syndrome 8


External Ids:

Disease Ontology8 DOID:11613
SNOMED-CT56 237793004
MeSH34 D017588

Related Diseases for Hyperandrogenism

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17GeneCards, 18GeneDecks
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Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.3SHBG, IGFBP1, POMC, CYP17A1, CYP21A2, CYP11A1
2obesity31.0CYP11A1, MC4R, RETN, INS, INSL3, SRD5A1
3acanthosis nigricans30.8SHBG, CYP21A2, INS
4anovulation30.7INS, CYP21A2, IGFBP1, SHBG, GNRH1, SRD5A1
5hyperinsulinism30.6GNRH1, LSL, SHBG, IGFBP1, INS, RETN
6acne30.5SHBG
7amenorrhea30.4INS, POMC, SHBG, GNRH1
8diabetes mellitus30.4CAPN10, LSL, SHBG, IGFBP1, POMC, MC4R
9infertility30.4GNRH1, SHBG, IGFBP1, CYP21A2, CYP11A1, RETN
10congenital adrenal hyperplasia30.4GNRH1, POMC, CYP17A1, CYP21A2, CYP11A1, SRD5A1
11alopecia30.3SHBG
12ovarian disease30.3GNRH1, SHBG, IGFBP1
13leydig cell tumor30.2HSD3BP4, LHCGR, GNRH1, CGB5, POMC, CYP17A1
14androgenic alopecia30.1SRD5A1, CYP21A2, SHBG
15hypertension30.1POMC, CYP17A1, RETN, INS
16hyperprolactinemia30.1GNRH1, CGB5, SHBG, POMC, SRD5A1
17adrenal adenoma30.1HSD3BP4, POMC, CYP17A1, CYP21A2, CYP11A1
18prostatitis30.0SRD5A1
19hepatitis30.0IGFBP1
20ovarian cancer30.0LHCGR, GNRH1, CGB5, CYP17A1
21glucose intolerance30.0CAPN10, LSL, SHBG, IGFBP1, RETN, INS
22adenoma30.0HSD3BP4, LHCGR, GNRH1, SHBG, IGFBP1, POMC
23cushing's syndrome29.8CYP21A2, INS, POMC
24laron syndrome29.8IGFBP1
25hyperthyroidism29.8LSL, CGB5, SHBG, RETN, INS, SRD5A1
26colorectal cancer29.8CYP17A1
27acromegaly29.8LSL, GNRH1, SHBG, IGFBP1, POMC, RETN
28hyperglycemia29.8LSL, IGFBP1, POMC, RETN, INS
29breast cancer29.8LHCGR, GNRH1, SHBG, IGFBP1, CYP17A1, CYP21A2
30atherosclerosis29.8CAPN10, LSL, SHBG, RETN, INS
31schizophrenia29.8INS
3221-hydroxylase deficiency10.3
33mullerian aplasia and hyperandrogenism10.2
34type 1 diabetes mellitus10.1
35hair-an syndrome10.1
36biliary atresia10.0
37adult syndrome10.0
38hemangioma10.0
39cortisone reductase deficiency 110.0
40thyroiditis10.0POMC
41hypogonadotropism10.0GNRH1
42graves' disease10.0CYP21A2, SHBG
43blindness10.0INS
44pseudohermaphroditism10.0HSD3B2, LHCGR, CYP17A1
45ovarian hyperstimulation syndrome10.0GNRH1, CGB5
46hypoadrenalism10.0POMC
47prolactinoma10.0POMC, GNRH1
48diabetes insipidus10.0POMC
49hyperaldosteronism10.0CYP21A2, CYP17A1, POMC
50essential hypertension10.0INS, RETN, SHBG

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to hyperandrogenism

Clinical Features for Hyperandrogenism

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Drugs & Therapeutics for Hyperandrogenism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperandrogenism

Drug clinical trials:

Search ClinicalTrials for Hyperandrogenism

Search NIH Clinical Center for Hyperandrogenism

Search CenterWatch for Hyperandrogenism

Genetic Tests for Hyperandrogenism

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Anatomical Context for Hyperandrogenism

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32MalaCards
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MalaCards organs/tissues related to Hyperandrogenism:

32
Ovary, Testes, Bone, Pituitary, Skin, Heart, Prostate, Adipocyte, Breast, Cortex, Endothelial, Adrenal cortex

Animal Models for Hyperandrogenism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperandrogenism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.5SRD5A1, CYP11A1, CAPN10, LHCGR
2MP:000536710.3CAPN10, GNRH1, POMC, INS, WNT4, LHCGR
3MP:000538910.3LHCGR, GNRH1, CYP17A1, CYP11A1, MC4R, INS
4MP:000537010.3CAPN10, GNRH1, IGFBP1, POMC, MC4R, RETN
5MP:000537510.2LHCGR, CAPN10, POMC, MC4R, RETN, INS
6MP:000538710.0LHCGR, CAPN10, GNRH1, IGFBP1, POMC, CYP11A1

Publications for Hyperandrogenism

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50PubMed
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Articles related to Hyperandrogenism:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Differences in sexual desire between women with clinical versus biochemical signs of hyperandrogenism in polycystic ovarian syndrome. (23127604)
2013
2
Does hyperandrogenism affect the otoacoustic emissions and medial olivocochlear reflex in female adults? (23770686)
2013
3
Pathophysiology of polycystic ovary syndrome: the role of hyperandrogenism. (24002402)
2013
4
Role of growth hormone and insulin-like growth factor-I in hyperandrogenism and the severity of acne vulgaris in young males. (23147876)
2012
5
Hyperandrogenism and intersex controversies in women's olympics. (22990091)
2012
6
Paratubal cysts, obesity, and hyperandrogenism. (22075351)
2011
7
Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome. (20705157)
2010
8
Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndrome. (19209619)
2008
9
Hyperandrogenism in broiler chickens and commercial layers. (18178935)
2008
10
The investigation and management of severe hyperandrogenism pre- and postmenopause: non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin. (18210332)
2008
11
Whither PCOS? The challenges of establishing hyperandrogenism in adolescent girls. (18639782)
2008
12
Evaluating hyperandrogenism: a challenge in acne management. (18561581)
2008
13
Androgen secreting steroid cell tumor of the ovary in a young lactating women with acute onset of severe hyperandrogenism: a case report and review of literature. (18088412)
2007
14
Maternal hyperandrogenism beginning from early pregnancy and progressing until delivery does not produce virilization of a female newborn. (17852424)
2007
15
The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. (16492701)
2006
16
Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women. (16407452)
2006
17
Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome. (16174719)
2005
18
Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess. (11779609)
2002
19
AACE hyperandrogenism guidelines. (11930513)
2001
20
Valproate treatment and the risk of hyperandrogenism and polycystic ovaries. (11254018)
2000
21
Hyperhidrosis as the only manifestation of hyperandrogenism in an adolescent girl. (10724221)
2000
22
Normal ovulatory women with polycystic ovaries have hyperandrogenic pituitary-ovarian responses to gonadotropin-releasing hormone-agonist testing. (10720029)
2000
23
Glucocorticoid resistance in premature pubarche and adolescent hyperandrogenism. (10068517)
1999
24
Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status. (10427156)
1999
25
Comparison of ovarian electrocautery and oral contraceptives in the treatment of hyperandrogenism in women with polycystic ovary syndrome. (10376864)
1999
26
Syndromes of hyperandrogenism in women. (10376368)
1999
27
How possible is the prevention of polycystic ovary syndrome development in adolescent patients with early onset of hyperandrogenism. (9856415)
1998
28
Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism. (9093190)
1997
29
The effects of hyperinsulinmia and insulin-like growth factor-1 on hyperandrogenism in polycystic ovarian syndrome]. (9596926)
1997
30
Relation of functional ovarian hyperandrogenism to non-insulin dependent diabetes mellitus. (9536214)
1997
31
Different dysregulations in adrenal steroid biosynthesis as a prevalent cause of hyperandrogenism in women from southern Italy. (9240249)
1997
32
An investigation of hyperandrogenism and obesity presenting during late childhood. (9293317)
1997
33
A case of severe hyperandrogenism, acanthosis nigricans and over diabetes: the use of non-invasive methods for diagnosis, pathogenesis and management. (8915663)
1996
34
Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity. (8772544)
1996
35
Hyperandrogenic states in women (polycystic ovary syndrome) and insulin resistance]. (7725637)
1995
36
Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman]. (7809540)
1994
37
Immunoradiometric assay of human intact proinsulin applied to patients with type 2 diabetes, impaired glucose tolerance, and hyperandrogenism. (8174247)
1994
38
Ketoconazole therapy: hormonal and clinical effects in non-tumoral hyperandrogenism. (8162160)
1994
39
Amenorrhea, insulin resistance and acanthosis nigricans. A hyperandrogenic and a normoandrogenic clinical forms]. (8303114)
1993
40
3 beta-hydroxysteroid dehydrogenase deficiency in hyperandrogenism. (8456898)
1993
41
Congenital adrenal hyperplasia among peripubertal girls with hyperandrogenism. (1601502)
1992
42
Postmenopausal hyperandrogenism of ovarian origin. A clinicopathologic study of four cases. (1526532)
1992
43
Sebum measurements for rapid identification of hyperandrogenism due to an ovarian Leydig cell tumor. (2050456)
1991
44
Study of the source(s) of hyperandrogenism in women with idiopathic hirsutism. (2147915)
1990
45
Hyperandrogenism in premenopausal women]. (2181598)
1990
46
Lymphocytes subset in hyperandrogenic women with polycystic ovarian disease. (2906494)
1988
47
Hyperinsulinemia and ovarian hyperandrogenism. Cause and effect. (3058472)
1988
48
Acne and hyperandrogenism. (6232296)
1984
49
Ovarian and adrenal vein steroids in patients with nonneoplastic hyperandrogenism: selective catheterization findings. (6233180)
1984
50
Diurnal change of serum androstenedione and testosterone and response to hCG and dexamethasone in women with polycystic ovaries, adrenal hyperandrogenism and unexplained hirsutism. (7189630)
1980

Genetic Variations for Hyperandrogenism

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Expression for genes affiliated with Hyperandrogenism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperandrogenism

Search GEO for disease gene expression data for Hyperandrogenism.

Pathways for genes affiliated with Hyperandrogenism

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Hyperandrogenism

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Hyperandrogenism according to GeneCards/GeneDecks:

(show top 50)    (show all 161)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9SRD5A1
2forskolin44 49 1112.7RETN, LHCGR, CYP17A1, POMC
3doca4410.7CYP11A1, HSD3BP4, CYP21A2, CYP17A1, POMC, SRD5A1
4clomiphene citrate4410.7GNRH1, CGB5, IGFBP1, CYP21A2, INS, SHBG
517-hydroxypregnenolone4410.7CYP21A2, CYP17A1, POMC, IGFBP1, SHBG, CGB5
6Pregnenolone11 2411.7HSD3B2, CYP17A1, CYP21A2, CYP11A1
7corticosterone44 59 2412.7LHCGR, MC4R, CYP11A1, CYP21A2, POMC, IGFBP1
8metformin44 49 1112.7LSL, GNRH1, SHBG, IGFBP1, POMC, CYP17A1
9ketoconazole44 28 11 2413.7SRD5A1, CYP11A1, CYP21A2, CYP17A1, POMC, SHBG
1011beta-hydroxysteroid4410.7POMC, CGB5, HSD3BP4, HSD3B2, CYP17A1, CYP21A2
11leuprolide acetate4410.7SHBG, LHCGR, GNRH1, CYP21A2, CGB5
12norepinephrine44 11 2412.7CYP21A2, POMC, CGB5, GNRH1, RETN
1317beta-hydroxysteroid4410.7SRD5A1, CYP11A1, HSD3B2, CGB5, CYP17A1, CYP21A2
14goserelin44 28 1112.7SRD5A1, GNRH1, LSL, SHBG, LHCGR
15progestin4410.7HSD3BP4, LHCGR, GNRH1, CGB5, SHBG, IGFBP1
16dihydrotestosterone44 28 11 2413.7HSD3B2, IGFBP1, GNRH1, CGB5, CYP17A1, CYP21A2
17acth 1-244410.7POMC, CYP17A1, CYP21A2, CYP11A1
18spironolactone49 44 59 28 1114.7SRD5A1, GNRH1, POMC, SHBG, CYP21A2
193beta-hydroxysteroid4410.7CGB5, LHCGR, HSD3BP4, HSD3B2, POMC, CYP17A1
20c-peptide4410.6IGFBP1, SHBG, LSL, CYP21A2, INS, RETN
21estrone44 28 11 2413.6CYP17A1, SHBG, LSL, GNRH1, CGB5, SRD5A1
22thyroxine44 2411.6RETN, CYP21A2, POMC, IGFBP1, GNRH1, INS
23acth4410.6CYP21A2, CYP17A1, POMC, IGFBP1, CGB5, GNRH1
24ribonucleic acid4410.6CYP17A1, IGFBP1, CGB5, CYP21A2, CYP11A1, POMC
25gnrh4410.6CGB5, SHBG, IGFBP1, POMC, CYP17A1, CYP21A2
26cholesterol44 28 11 2413.6HSD3B2, HSD3BP4, LHCGR, CAPN10, LSL, SHBG
27epinephrine44 11 2412.6INS, GNRH1, CYP21A2, POMC, CGB5, SHBG
2817-hydroxyprogesterone44 2411.6POMC, IGFBP1, SHBG, CGB5, GNRH1, HSD3BP4
29dehydroepiandrosterone sulfate4410.6HSD3B2, HSD3BP4, LSL, GNRH1, SHBG, CGB5
30dhea4410.6SRD5A1, INS, RETN, CYP11A1, CYP21A2, CYP17A1
31androstenedione44 2411.6SRD5A1, INS, CYP11A1, CYP21A2, CYP17A1, POMC
32mifepristone44 59 28 1113.6HSD3BP4, IGFBP1, POMC, SHBG, CGB5, GNRH1
33alanine4410.6MC4R, SHBG, LSL, LHCGR, INSL3, INS
34arginine4410.6IGFBP1, SHBG, LSL, GNRH1, POMC, CYP17A1
35leuprolide44 59 28 1113.6GNRH1, LSL, SRD5A1, CGB5
36dexamethasone44 49 28 1113.6HSD3BP4, LSL, GNRH1, CGB5, SHBG, IGFBP1
37hydrocortisone44 2 59 1113.6IGFBP1, LSL, SHBG, POMC, CYP21A2, INS
38estradiol44 11 2412.6GNRH1, POMC, CYP17A1, CYP21A2, CYP11A1, RETN
39diethylstilbestrol44 28 1112.5GNRH1, CGB5, CYP17A1, INSL3, SHBG
40progesterone44 59 28 11 2414.5HSD3BP4, SRD5A1, LHCGR, LSL, GNRH1, CGB5
41steroid4410.5SHBG, INSL3, IGFBP1, POMC, CYP17A1, CYP21A2
42glucose4410.5CYP21A2, LSL, CGB5, POMC
43testosterone44 59 11 2413.5IGFBP1, POMC, CYP17A1, CYP21A2, CYP11A1, RETN
4411 deoxycortisol4410.5SHBG, POMC, CYP17A1, CYP21A2
45rosiglitazone44 49 28 11 2414.5IGFBP1, CYP17A1, SHBG, LSL, RETN, INS
46lipid4410.5CYP17A1, CYP21A2, CYP11A1, MC4R, RETN, SHBG
47valproate4410.4CYP11A1, CYP17A1, IGFBP1, LSL, SHBG
48dihydroprogesterone4410.4HSD3BP4, SRD5A1, CYP11A1, CGB5
49allopregnanolone4410.3SHBG, POMC, GNRH1, SRD5A1
50aminoglutethimide44 1111.1CYP11A1, CYP21A2, POMC, CGB5

GO Terms for genes affiliated with Hyperandrogenism

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16Gene Ontology
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Cellular components related to Hyperandrogenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.4INS, POMC
2extracellular regionGO:00557610.2WNT4, GNRH1, SHBG, IGFL3, IGFBP1, POMC
3extracellular spaceGO:00561510.0GNRH1, IGFBP1, POMC, RETN, INS, INSL3

Biological processes related to Hyperandrogenism according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00670410.7CYP21A2, CYP17A1, HSD3B2
2sterol metabolic processGO:01612510.7CYP17A1, CYP21A2, CYP11A1
3negative regulation of feeding behaviorGO:200025210.7MC4R, INS
4androgen biosynthetic processGO:00670210.7SRD5A1, WNT4, CYP17A1, HSD3B2
5response to fungicideGO:06099210.7CYP17A1, CYP11A1
6steroid metabolic processGO:00820210.7HSD3B2, CYP17A1, CYP21A2, CYP11A1, SRD5A1
7dibenzo-p-dioxin metabolic processGO:01889410.7CYP17A1, CYP11A1
8biphenyl metabolic processGO:01887910.7CYP17A1, CYP11A1
9cell-cell signalingGO:00726710.6WNT4, INSL3, INS, POMC, GNRH1
10response to insecticideGO:01708510.6CYP17A1, CYP11A1
11phthalate metabolic processGO:01896310.6CYP17A1, CYP11A1
12phenol-containing compound metabolic processGO:01895810.6CYP17A1, CYP11A1
13mineralocorticoid biosynthetic processGO:00670510.6HSD3B2, CYP21A2
14cellular response to antibioticGO:07123610.5CYP17A1, CYP11A1
15sex differentiationGO:00754810.4SRD5A1, CYP17A1
16male gonad developmentGO:00858410.4WNT4, INSL3, LHCGR
17cellular response to gonadotropin stimulusGO:07137110.3LHCGR, CYP17A1
18Leydig cell differentiationGO:03332710.1CYP11A1, CYP17A1

Molecular functions related to Hyperandrogenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:00905510.4SRD5A1, CYP11A1, CYP21A2, CYP17A1
2hormone activityGO:00517910.1INSL3, INS, RETN, POMC, GNRH1

Products for genes affiliated with Hyperandrogenism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperandrogenism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet