MCID: HYP043
MIFTS: 48

Hyperandrogenism malady

Summaries for Hyperandrogenism

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Wikipedia:65 Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive levels of... more...

MalaCards based summary: Hyperandrogenism, also known as hyperandrogenization syndrome, is related to polycystic ovary syndrome and obesity. An important gene associated with Hyperandrogenism is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism of steroid hormones and vitamin D. The compounds 21-Hydroxypregnenolone and 17a,21-Dihydroxypreg-nenolone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Hyperandrogenism

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 35MeSH, 57SNOMED-CT
See all sources

Hyperandrogenism, Aliases & Descriptions:

Name: Hyperandrogenism 10 12 45 62
Hyperandrogenization Syndrome 10
 
Hyperandrogenisation Syndrome 62


External Ids:

Disease Ontology10 DOID:11613
SNOMED-CT57 237793004
MeSH35 D017588

Related Diseases for Hyperandrogenism

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Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.4CAPN10, CYP11A1, CYP21A2, SHBG, HSD3B2
2obesity31.0CAPN10, CYP21A2, MC4R, CYP11A1, SHBG, INSL3
3acanthosis nigricans30.9SHBG, CYP21A2
4anovulation30.9SHBG, CYP21A2
5acne30.7SHBG
6hyperinsulinism30.7MC4R, SHBG
7amenorrhea30.7SHBG
8congenital adrenal hyperplasia30.5HSD3B2, CYP21A2, CYP11A1
9oligomenorrhea30.5CYP21A2, SHBG
10alopecia30.5SHBG
11leydig cell tumor30.5LHCGR, CYP21A2, CYP11A1
12infertility30.4CAPN10, SHBG, LHCGR, INSL3, CYP21A2, CYP11A1
13precocious puberty30.4SHBG, LHCGR, CYP21A2
14adrenal adenoma30.3CYP21A2, CYP11A1
15glucose intolerance30.1CAPN10, SHBG
16adenoma30.1CYP11A1, CYP21A2, LHCGR, SHBG
17cushing's syndrome30.0CYP21A2
18breast cancer29.8LHCGR, SHBG, CYP11A1, WNT4, CYP21A2
19mullerian aplasia and hyperandrogenism10.6
20ovarian disease10.3
21hair-an syndrome10.3
22insulin-like growth factor i10.2
23hyperprolactinemia10.2
24adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency10.2
25endometrial cancer10.1
26hemangioma10.1
27hepatitis10.1
28sertoli-leydig cell tumor10.1
29transsexualism10.1
30biliary atresia10.1
31prostatitis10.1
32central precocious puberty10.1
33hyperandrogenism due to cortisone reductase deficiency10.1
34klinefelter's syndrome10.0SHBG, CYP21A2
35alopecia, androgenetic, 110.0SHBG, CYP21A2
36turner syndrome10.0CYP21A2, SHBG
37hypopituitarism10.0SHBG, CYP21A2
38cryptorchidism10.0SHBG, INSL3
39autoimmune polyendocrine syndrome type 110.0CYP11A1, CYP21A2
40male infertility10.0SHBG, CYP21A2
41conn's syndrome10.0CYP11A1, CYP21A2
42uterine fibroid10.0SHBG, CYP21A2
43mody, type ii10.0CAPN10, SHBG
44premature ovarian failure10.0SHBG, CYP11A1
45testicular cancer10.0SHBG, INSL3
46adrenocortical carcinoma10.0CYP21A2, CYP11A1
47adrenal cortical adenoma10.0CYP11A1, CYP21A2
48hypospadias10.0CYP21A2, INSL3, HSD3B2
49graves' disease10.0CYP21A2, SHBG
50pseudohermaphroditism10.0LHCGR, HSD3B2

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to hyperandrogenism

Symptoms for Hyperandrogenism

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Drugs & Therapeutics for Hyperandrogenism

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Drug clinical trials:

Search ClinicalTrials for Hyperandrogenism

Search NIH Clinical Center for Hyperandrogenism

Genetic Tests for Hyperandrogenism

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Anatomical Context for Hyperandrogenism

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MalaCards organs/tissues related to Hyperandrogenism:

33
Ovary, Testes, Bone, Pituitary, Skin, Heart, Prostate, Neutrophil, Cortex, Adipocyte, Breast, Endothelial, Adrenal cortex

Animal Models for Hyperandrogenism or affiliated genes

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MGI Mouse Phenotypes related to Hyperandrogenism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1LHCGR, CYP11A1, INSL3, WNT4, CAPN10
2MP:00053877.6CYP11A1, LHCGR, MC4R, WNT4, CAPN10
3MP:00053897.5WNT4, CYP11A1, INSL3, LHCGR, MC4R
4MP:00053977.3LHCGR, MC4R, WNT4, CAPN10, CYP11A1

Publications for Hyperandrogenism

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Articles related to Hyperandrogenism:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Induction of Hyperandrogenism in Lean Reproductive-Age Women Stimulates Proatherogenic Inflammation. (25230323)
2014
2
Hyperreactio luteinalis in pregnancy and hyperandrogenism: a case report. (25330696)
2014
3
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. (24680383)
2014
4
Differences in sexual desire between women with clinical versus biochemical signs of hyperandrogenism in polycystic ovarian syndrome. (23127604)
2013
5
Does hyperandrogenism affect the otoacoustic emissions and medial olivocochlear reflex in female adults? (23770686)
2013
6
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
7
Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism. (22886405)
2012
8
Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis. (20518640)
2011
9
Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-KA1ster-Hauser syndrome). (21377155)
2011
10
Serum adiponectin levels in high school girls with polycystic ovary syndrome and hyperandrogenism. (21190873)
2011
11
The frequency of metabolic syndrome is higher among PCOS Brazilian women with menstrual irregularity plus hyperandrogenism. (22096008)
2011
12
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
13
Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty. (19232022)
2009
14
Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. (19832931)
2009
15
Polymorphism in CYP11alpha and CYP17 genes and the etiology of hyperandrogenism in patients with polycystic ovary syndrome]. (18499961)
2008
16
Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndrome. (19209619)
2008
17
Prevalence of nonclassic adrenal hyperplasia (NCAH) in hyperandrogenic women. (18335331)
2008
18
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
19
Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome. (17070182)
2006
20
Oligoanovulation with polycystic ovaries but not overt hyperandrogenism. (16849400)
2006
21
Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. (16263820)
2006
22
The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. (16492701)
2006
23
Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women. (15802316)
2005
24
Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women: the effect of cyproterone acetate-ethinyl estradiol treatment. (15031776)
2004
25
Macroprolactinemia in women presenting with hyperandrogenic symptoms: Implications for the management of polycystic ovary syndrome. (15589886)
2004
26
Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. (12880121)
2003
27
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
28
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate. (11823113)
2002
29
Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism. (12091857)
2002
30
Novel mutations in CYP21 detected in individuals with hyperandrogenism. (12050257)
2002
31
Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (12161545)
2002
32
Hyperandrogenism in adolescents. (11841957)
2002
33
Androgen suppression and clinical improvement with dopamine agonists in hyperandrogenic-hyperprolactinemic women. (11499189)
2001
34
Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women. (11297612)
2001
35
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases. (10891991)
2000
36
Serum levels of inhibins are differentially altered in patients with polycystic ovary syndrome: effects of being overweight and relevance to hyperandrogenism. (10785223)
2000
37
High bone density in hyperandrogenic women: effect of gonadotropin-releasing hormone agonist alone or in conjunction with estrogen-progestin replacement. (8636283)
1996
38
Chronic hyperinsulinemia and the adrenal androgen response to acute corticotropin-(1-24) stimulation in hyperandrogenic women. (7726265)
1995
39
Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman]. (7809540)
1994
40
Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome. (7968591)
1994
41
Clinical and endocrine effects of flutamide in hyperandrogenic women. (8224265)
1993
42
Defects in beta-cell function in functional ovarian hyperandrogenism. (8496316)
1993
43
Primary aldosteronism and hyperandrogenism. (1636018)
1992
44
Study of the source(s) of hyperandrogenism in women with idiopathic hirsutism. (2147915)
1990
45
On the origin of the elevated 17-hydroxyprogesterone levels after adrenal stimulation in hyperandrogenism. (2137133)
1990
46
Polycystic ovary syndrome: obesity, insulin resistance, hyperandrogenism. (2700062)
1989
47
The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia. (3192772)
1988
48
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (3305551)
1987
49
The consequences of hyperandrogenism in young women. (3323511)
1987
50
Treatment of severe hirsutism resulting from hyperandrogenism with the reverse sequential cyproterone acetate regimen. (6232380)
1984

Variations for Hyperandrogenism

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Expression for genes affiliated with Hyperandrogenism

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Search GEO for disease gene expression data for Hyperandrogenism.

Pathways for genes affiliated with Hyperandrogenism

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Pathways related to Hyperandrogenism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CYP21A2, CYP11A1
2
Show member pathways
9.2HSD3B2, CYP21A2, CYP11A1
39.2CYP11A1, CYP21A2, HSD3B2
4
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
9.2HSD3B2, CYP21A2, CYP11A1
58.9CYP11A1, LHCGR, HSD3B2
68.7MC4R, LHCGR, INSL3
7
Show member pathways
8.2INSL3, LHCGR, MC4R, WNT4

Compounds for genes affiliated with Hyperandrogenism

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Compounds related to Hyperandrogenism according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
121-Hydroxypregnenolone2610.1HSD3B2, CYP21A2
217a,21-Dihydroxypreg-nenolone2610.1HSD3B2, CYP21A2
311 deoxycortisol4510.1SHBG, CYP21A2
4Cortexolone2610.1CYP21A2, HSD3B2
5deoxycorticosterone30 2611.0CYP21A2, HSD3B2
6clomiphene citrate4510.0SHBG, CYP21A2
7cortisol30 2611.0CYP21A2, HSD3B2
83-alpha-androstanediol glucuronide45 2611.0SHBG, CYP21A2
9acth 1-244510.0CYP21A2, CYP11A1
10spironolactone45 61 30 51 1313.9CYP21A2, SHBG
11doca459.9CYP21A2, CYP11A1
12aminoglutethimide45 1310.9CYP11A1, CYP21A2
13medroxyprogesterone45 51 30 26 1313.8HSD3B2, CYP11A1
14goserelin45 30 1311.8LHCGR, SHBG
1517-hydroxypregnenolone459.7SHBG, CYP21A2, HSD3B2
16diethylstilbestrol45 30 1311.7INSL3, SHBG
17ketoconazole45 30 26 1312.7SHBG, CYP21A2, CYP11A1
1817a-Hydroxypregnenolone269.6CYP21A2, CYP11A1, HSD3B2
19Pregnenolone26 1310.6CYP21A2, CYP11A1, HSD3B2
20flutamide45 61 1311.6SHBG, LHCGR
2125-hydroxyvitamin d459.6CYP11A1, SHBG
22valproate459.6CYP11A1, SHBG
2311beta-hydroxysteroid459.6HSD3B2, CYP21A2, CYP11A1
2417beta-hydroxysteroid459.6HSD3B2, CYP21A2, CYP11A1
25leuprolide acetate459.6CYP21A2, SHBG, LHCGR
26progestin459.3SHBG, LHCGR, CYP11A1
2717-hydroxyprogesterone45 2610.2CYP11A1, CYP21A2, SHBG, HSD3B2
28dehydroepiandrosterone sulfate459.2CYP11A1, CYP21A2, SHBG, HSD3B2
29dhea459.2CYP21A2, SHBG, HSD3B2, CYP11A1
30androstenedione45 2610.2CYP11A1, HSD3B2, SHBG, CYP21A2
31dihydrotestosterone45 30 26 1312.2HSD3B2, SHBG, CYP11A1, CYP21A2
32ribonucleic acid459.2CYP11A1, LHCGR, CYP21A2
33gnrh459.0SHBG, CYP11A1, CYP21A2, LHCGR
34estradiol45 26 1311.0LHCGR, CYP11A1, CYP21A2, SHBG
35forskolin45 51 1310.9HSD3B2, CYP11A1, CYP21A2, LHCGR
363beta-hydroxysteroid458.7LHCGR, CYP11A1, CYP21A2, INSL3, HSD3B2
37glucose458.6SHBG, CYP21A2, MC4R, CAPN10
38corticosterone45 61 2610.6CYP11A1, CYP21A2, MC4R, LHCGR
39threonine458.6MC4R, INSL3, CYP21A2, LHCGR
40alanine458.5MC4R, INSL3, LHCGR, SHBG
41adenylate458.4MC4R, SHBG, LHCGR, CYP11A1
42lipid458.3CAPN10, CYP11A1, CYP21A2, SHBG, MC4R
43arginine458.3CAPN10, CYP21A2, MC4R, LHCGR, SHBG
44estrogen458.2SHBG, LHCGR, INSL3, CYP11A1, CYP21A2, HSD3B2
45progesterone45 30 61 26 1312.1CYP21A2, LHCGR, WNT4, HSD3B2, SHBG, CYP11A1
46acth457.8CYP11A1, LHCGR, CYP21A2, SHBG, HSD3B2, MC4R
47testosterone45 61 26 1310.8INSL3, WNT4, CYP11A1, CYP21A2, LHCGR, SHBG
48calcium45 51 26 1310.5MC4R, LHCGR, CAPN10, CYP21A2, CYP11A1
49steroid457.5CYP11A1, MC4R, SHBG, LHCGR, INSL3, CYP21A2
50cholesterol45 30 26 1310.4MC4R, LHCGR, SHBG, CYP21A2, HSD3B2, CAPN10

GO Terms for genes affiliated with Hyperandrogenism

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Biological processes related to Hyperandrogenism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mineralocorticoid biosynthetic processGO:00067059.8CYP21A2, HSD3B2
2glucocorticoid biosynthetic processGO:00067049.8CYP21A2, HSD3B2
3sterol metabolic processGO:00161259.5CYP21A2, CYP11A1
4androgen biosynthetic processGO:00067029.5WNT4, HSD3B2
5steroid metabolic processGO:00082029.4CYP11A1, CYP21A2, HSD3B2
6positive regulation of cAMP biosynthetic processGO:00308199.3MC4R, INSL3
7cellular response to transforming growth factor beta stimulusGO:00715609.1WNT4, CYP11A1
8male gonad developmentGO:00085849.1WNT4, INSL3, LHCGR

Products for genes affiliated with Hyperandrogenism

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Sources for Hyperandrogenism

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet