Aliases & Classifications for Hyperandrogenism

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Hyperandrogenism, Aliases & Descriptions:

Name: Hyperandrogenism 9 11 43 60
 
Hyperandrogenization Syndrome 9


External Ids:

Disease Ontology9 DOID:11613
SNOMED-CT55 237793004
MeSH33 D017588

Summaries for Hyperandrogenism

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Wikipedia:63 Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive levels of... more...

MalaCards based summary: Hyperandrogenism, also known as hyperandrogenization syndrome, is related to acanthosis nigricans and acne. An important gene associated with Hyperandrogenism is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism of steroid hormones and vitamin D. The compounds 21-Hydroxypregnenolone and 17a,21-Dihydroxypreg-nenolone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Related Diseases for Hyperandrogenism

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Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1acanthosis nigricans31.4SHBG, CYP21A2
2acne31.3SHBG
3anovulation31.3SHBG, CYP21A2
4amenorrhea31.2SHBG
5polycystic ovary syndrome31.1CAPN10, CYP11A1, CYP21A2, SHBG, HSD3B2
6alopecia31.1SHBG
7oligomenorrhea31.0CYP21A2, SHBG
8hyperinsulinism30.8MC4R, SHBG
9congenital adrenal hyperplasia30.6HSD3B2, CYP21A2, CYP11A1
10adrenal adenoma30.6CYP21A2, CYP11A1
11cushing's syndrome30.6CYP21A2
12precocious puberty30.5SHBG, LHCGR, CYP21A2
13leydig cell tumor30.5LHCGR, CYP21A2, CYP11A1
14glucose intolerance30.4CAPN10, SHBG
15obesity30.3CAPN10, CYP21A2, MC4R, CYP11A1, SHBG, INSL3
16adenoma29.9CYP11A1, CYP21A2, LHCGR, SHBG
17infertility29.8CAPN10, SHBG, LHCGR, INSL3, CYP21A2, CYP11A1
18breast cancer29.3LHCGR, SHBG, CYP11A1, WNT4, CYP21A2
19mullerian aplasia and hyperandrogenism10.6
20klinefelter's syndrome10.3SHBG, CYP21A2
21alopecia, androgenetic, 110.3SHBG, CYP21A2
22turner syndrome10.3CYP21A2, SHBG
23hypopituitarism10.3SHBG, CYP21A2
24ovarian disease10.3
25hair-an syndrome10.3
26cryptorchidism10.3SHBG, INSL3
27autoimmune polyendocrine syndrome type 110.3CYP11A1, CYP21A2
28male infertility10.3SHBG, CYP21A2
29conn's syndrome10.3CYP11A1, CYP21A2
30uterine fibroid10.2SHBG, CYP21A2
31insulin-like growth factor i10.2
32mody, type ii10.2CAPN10, SHBG
33premature ovarian failure10.2SHBG, CYP11A1
34testicular cancer10.2SHBG, INSL3
35adrenocortical carcinoma10.2CYP21A2, CYP11A1
36adrenal cortical adenoma10.2CYP11A1, CYP21A2
37hyperprolactinemia10.2
38adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency10.2
39hyperandrogenism due to cortisone reductase deficiency10.2
40hypospadias10.2CYP21A2, INSL3, HSD3B2
41graves' disease10.2CYP21A2, SHBG
42pseudohermaphroditism10.2LHCGR, HSD3B2
43metabolic syndrome x10.1CYP21A2, CAPN10, SHBG
44abrikosov's tumor10.1CYP11A1, LHCGR
45endometrial cancer10.1
46hemangioma10.1
47hepatitis10.1
48sertoli-leydig cell tumor10.1
49transsexualism10.1
50biliary atresia10.1

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to hyperandrogenism

Symptoms for Hyperandrogenism

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Drugs & Therapeutics for Hyperandrogenism

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Drug clinical trials:

Search ClinicalTrials for Hyperandrogenism

Search NIH Clinical Center for Hyperandrogenism

Genetic Tests for Hyperandrogenism

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Anatomical Context for Hyperandrogenism

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MalaCards organs/tissues related to Hyperandrogenism:

31
Ovary, Testes, Bone, Pituitary, Skin, Heart, Prostate, Neutrophil, Cortex, Adipocyte, Breast, Endothelial, Adrenal cortex

Animal Models for Hyperandrogenism or affiliated genes

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MGI Mouse Phenotypes related to Hyperandrogenism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1LHCGR, CYP11A1, INSL3, WNT4, CAPN10
2MP:00053877.6CYP11A1, LHCGR, MC4R, WNT4, CAPN10
3MP:00053897.5WNT4, CYP11A1, INSL3, LHCGR, MC4R
4MP:00053977.3LHCGR, MC4R, WNT4, CAPN10, CYP11A1

Publications for Hyperandrogenism

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Articles related to Hyperandrogenism:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Induction of Hyperandrogenism in Lean Reproductive-Age Women Stimulates Proatherogenic Inflammation. (25230323)
2014
2
Hyperreactio luteinalis in pregnancy and hyperandrogenism: a case report. (25330696)
2014
3
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. (24680383)
2014
4
Differences in sexual desire between women with clinical versus biochemical signs of hyperandrogenism in polycystic ovarian syndrome. (23127604)
2013
5
Does hyperandrogenism affect the otoacoustic emissions and medial olivocochlear reflex in female adults? (23770686)
2013
6
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
7
Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism. (22886405)
2012
8
Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis. (20518640)
2011
9
Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-KA1ster-Hauser syndrome). (21377155)
2011
10
Serum adiponectin levels in high school girls with polycystic ovary syndrome and hyperandrogenism. (21190873)
2011
11
The frequency of metabolic syndrome is higher among PCOS Brazilian women with menstrual irregularity plus hyperandrogenism. (22096008)
2011
12
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
13
Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty. (19232022)
2009
14
Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. (19832931)
2009
15
Polymorphism in CYP11alpha and CYP17 genes and the etiology of hyperandrogenism in patients with polycystic ovary syndrome]. (18499961)
2008
16
Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndrome. (19209619)
2008
17
Prevalence of nonclassic adrenal hyperplasia (NCAH) in hyperandrogenic women. (18335331)
2008
18
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
19
Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome. (17070182)
2006
20
Oligoanovulation with polycystic ovaries but not overt hyperandrogenism. (16849400)
2006
21
Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. (16263820)
2006
22
The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. (16492701)
2006
23
Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women. (15802316)
2005
24
Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women: the effect of cyproterone acetate-ethinyl estradiol treatment. (15031776)
2004
25
Macroprolactinemia in women presenting with hyperandrogenic symptoms: Implications for the management of polycystic ovary syndrome. (15589886)
2004
26
Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. (12880121)
2003
27
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
28
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate. (11823113)
2002
29
Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism. (12091857)
2002
30
Novel mutations in CYP21 detected in individuals with hyperandrogenism. (12050257)
2002
31
Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (12161545)
2002
32
Hyperandrogenism in adolescents. (11841957)
2002
33
Androgen suppression and clinical improvement with dopamine agonists in hyperandrogenic-hyperprolactinemic women. (11499189)
2001
34
Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women. (11297612)
2001
35
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases. (10891991)
2000
36
Serum levels of inhibins are differentially altered in patients with polycystic ovary syndrome: effects of being overweight and relevance to hyperandrogenism. (10785223)
2000
37
High bone density in hyperandrogenic women: effect of gonadotropin-releasing hormone agonist alone or in conjunction with estrogen-progestin replacement. (8636283)
1996
38
Chronic hyperinsulinemia and the adrenal androgen response to acute corticotropin-(1-24) stimulation in hyperandrogenic women. (7726265)
1995
39
Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman]. (7809540)
1994
40
Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome. (7968591)
1994
41
Clinical and endocrine effects of flutamide in hyperandrogenic women. (8224265)
1993
42
Defects in beta-cell function in functional ovarian hyperandrogenism. (8496316)
1993
43
Primary aldosteronism and hyperandrogenism. (1636018)
1992
44
Study of the source(s) of hyperandrogenism in women with idiopathic hirsutism. (2147915)
1990
45
On the origin of the elevated 17-hydroxyprogesterone levels after adrenal stimulation in hyperandrogenism. (2137133)
1990
46
Polycystic ovary syndrome: obesity, insulin resistance, hyperandrogenism. (2700062)
1989
47
The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia. (3192772)
1988
48
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (3305551)
1987
49
The consequences of hyperandrogenism in young women. (3323511)
1987
50
Treatment of severe hirsutism resulting from hyperandrogenism with the reverse sequential cyproterone acetate regimen. (6232380)
1984

Variations for Hyperandrogenism

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Expression for genes affiliated with Hyperandrogenism

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Search GEO for disease gene expression data for Hyperandrogenism.

Pathways for genes affiliated with Hyperandrogenism

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Pathways related to Hyperandrogenism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CYP21A2, CYP11A1
2
Show member pathways
9.2HSD3B2, CYP21A2, CYP11A1
39.2CYP11A1, CYP21A2, HSD3B2
4
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.2HSD3B2, CYP21A2, CYP11A1
58.9CYP11A1, LHCGR, HSD3B2
68.7MC4R, LHCGR, INSL3
7
Show member pathways
8.2INSL3, LHCGR, MC4R, WNT4

Compounds for genes affiliated with Hyperandrogenism

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Compounds related to Hyperandrogenism according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
121-Hydroxypregnenolone2410.1HSD3B2, CYP21A2
217a,21-Dihydroxypreg-nenolone2410.1HSD3B2, CYP21A2
311 deoxycortisol4310.1SHBG, CYP21A2
4Cortexolone2410.1CYP21A2, HSD3B2
5deoxycorticosterone28 2411.0CYP21A2, HSD3B2
6clomiphene citrate4310.0SHBG, CYP21A2
7cortisol28 2411.0CYP21A2, HSD3B2
83-alpha-androstanediol glucuronide43 2411.0SHBG, CYP21A2
9acth 1-244310.0CYP21A2, CYP11A1
10spironolactone43 59 28 49 1213.9CYP21A2, SHBG
11doca439.9CYP21A2, CYP11A1
12aminoglutethimide43 1210.9CYP11A1, CYP21A2
13medroxyprogesterone43 49 28 24 1213.8HSD3B2, CYP11A1
14goserelin43 28 1211.8LHCGR, SHBG
1517-hydroxypregnenolone439.7SHBG, CYP21A2, HSD3B2
16diethylstilbestrol43 28 1211.7INSL3, SHBG
17ketoconazole43 28 24 1212.7SHBG, CYP21A2, CYP11A1
1817a-Hydroxypregnenolone249.6CYP21A2, CYP11A1, HSD3B2
19Pregnenolone24 1210.6CYP21A2, CYP11A1, HSD3B2
20flutamide43 59 1211.6SHBG, LHCGR
2125-hydroxyvitamin d439.6CYP11A1, SHBG
22valproate439.6CYP11A1, SHBG
2311beta-hydroxysteroid439.6HSD3B2, CYP21A2, CYP11A1
2417beta-hydroxysteroid439.6HSD3B2, CYP21A2, CYP11A1
25leuprolide acetate439.6CYP21A2, SHBG, LHCGR
26progestin439.3SHBG, LHCGR, CYP11A1
2717-hydroxyprogesterone43 2410.2CYP11A1, CYP21A2, SHBG, HSD3B2
28dehydroepiandrosterone sulfate439.2CYP11A1, CYP21A2, SHBG, HSD3B2
29dhea439.2CYP21A2, SHBG, HSD3B2, CYP11A1
30androstenedione43 2410.2CYP11A1, HSD3B2, SHBG, CYP21A2
31dihydrotestosterone43 28 24 1212.2HSD3B2, SHBG, CYP11A1, CYP21A2
32ribonucleic acid439.2CYP11A1, LHCGR, CYP21A2
33gnrh439.0SHBG, CYP11A1, CYP21A2, LHCGR
34estradiol43 24 1211.0LHCGR, CYP11A1, CYP21A2, SHBG
35forskolin43 49 1210.9HSD3B2, CYP11A1, CYP21A2, LHCGR
363beta-hydroxysteroid438.7LHCGR, CYP11A1, CYP21A2, INSL3, HSD3B2
37glucose438.6SHBG, CYP21A2, MC4R, CAPN10
38corticosterone43 59 2410.6CYP11A1, CYP21A2, MC4R, LHCGR
39threonine438.6MC4R, INSL3, CYP21A2, LHCGR
40alanine438.5MC4R, INSL3, LHCGR, SHBG
41adenylate438.4MC4R, SHBG, LHCGR, CYP11A1
42lipid438.3CAPN10, CYP11A1, CYP21A2, SHBG, MC4R
43arginine438.3CAPN10, CYP21A2, MC4R, LHCGR, SHBG
44estrogen438.2SHBG, LHCGR, INSL3, CYP11A1, CYP21A2, HSD3B2
45progesterone43 28 59 24 1212.1CYP21A2, LHCGR, WNT4, HSD3B2, SHBG, CYP11A1
46acth437.8CYP11A1, LHCGR, CYP21A2, SHBG, HSD3B2, MC4R
47testosterone43 59 24 1210.8INSL3, WNT4, CYP11A1, CYP21A2, LHCGR, SHBG
48calcium43 49 24 1210.5MC4R, LHCGR, CAPN10, CYP21A2, CYP11A1
49steroid437.5CYP11A1, MC4R, SHBG, LHCGR, INSL3, CYP21A2
50cholesterol43 28 24 1210.4MC4R, LHCGR, SHBG, CYP21A2, HSD3B2, CAPN10

GO Terms for genes affiliated with Hyperandrogenism

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Biological processes related to Hyperandrogenism according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mineralocorticoid biosynthetic processGO:00067059.8HSD3B2, CYP21A2
2glucocorticoid biosynthetic processGO:00067049.8CYP21A2, HSD3B2
3sterol metabolic processGO:00161259.5CYP21A2, CYP11A1
4androgen biosynthetic processGO:00067029.5WNT4, HSD3B2
5steroid metabolic processGO:00082029.4HSD3B2, CYP21A2, CYP11A1
6positive regulation of cAMP biosynthetic processGO:00308199.3MC4R, INSL3
7cellular response to transforming growth factor beta stimulusGO:00715609.1WNT4, CYP11A1
8male gonad developmentGO:00085849.1WNT4, LHCGR, INSL3

Products for genes affiliated with Hyperandrogenism

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Sources for Hyperandrogenism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
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46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet