MCID: HYP043
MIFTS: 52

Hyperandrogenism malady

Summaries for Hyperandrogenism

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive production... more...

MalaCards: Hyperandrogenism, also known as hyperandrogenization syndrome, is related to polycystic ovary syndrome and insulin resistance. An important gene associated with Hyperandrogenism is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cytochrome P450 - arranged by substrate type and Endogenous sterols. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, cortex and heart, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Hyperandrogenism

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

hyperandrogenism 8 10 45 61
hyperandrogenization syndrome 8


External Ids:

Disease Ontology8 DOID:11613
SNOMED-CT57 237793004
MeSH35 D017588

Related Diseases for Hyperandrogenism

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.3SHBG, IGFBP1, POMC, CYP17A1, CYP21A2, CYP11A1
2insulin resistance31.1CAPN10, LSL, SHBG, IGFBP1, CYP17A1, CYP21A2
3acanthosis nigricans30.8SHBG, CYP21A2, INS
4anovulation30.7INS, CYP21A2, IGFBP1, SHBG, GNRH1, SRD5A1
5hyperinsulinism30.6GNRH1, LSL, SHBG, IGFBP1, INS, RETN
6acne30.5SHBG
7amenorrhea30.4INS, POMC, SHBG, GNRH1
8congenital adrenal hyperplasia30.4GNRH1, POMC, CYP17A1, CYP21A2, CYP11A1, SRD5A1
9alopecia30.3SHBG
10precocious puberty30.3POMC, CYP21A2, SHBG, CGB5, GNRH1, LHCGR
11infertility30.2GNRH1, SHBG, IGFBP1, CYP21A2, CYP11A1, RETN
12hyperprolactinemia30.2GNRH1, CGB5, SHBG, POMC, SRD5A1
13adrenal adenoma30.2HSD3BP4, POMC, CYP17A1, CYP21A2, CYP11A1
14glucose intolerance30.0CAPN10, LSL, SHBG, IGFBP1, RETN, INS
15adenoma30.0HSD3BP4, LHCGR, GNRH1, SHBG, IGFBP1, POMC
16cushing's syndrome29.8CYP21A2, INS, POMC
17laron syndrome29.8IGFBP1
18androgenic alopecia29.8SRD5A1, CYP21A2, SHBG
19coronary heart disease29.8INS, RETN, SHBG
20colorectal cancer29.8CYP17A1
21acromegaly29.8LSL, GNRH1, SHBG, IGFBP1, POMC, RETN
22atherosclerosis29.8CAPN10, LSL, SHBG, RETN, INS
23n syndrome10.5
24hair-an syndrome10.2
25mass syndrome10.2
26mullerian aplasia and hyperandrogenism10.2
2721-hydroxylase deficiency10.1
28char syndrome10.1
29bod syndrome10.1
30erythrocytosis10.1
31biliary atresia10.0
32adult syndrome10.0
33central precocious puberty10.0
34cortisone reductase deficiency 110.0
35prostatitis10.0SRD5A1
36thyroiditis10.0POMC
37hypogonadotropism10.0GNRH1
38graves' disease10.0CYP21A2, SHBG
39hepatitis10.0IGFBP1
40blindness10.0INS
41pseudohermaphroditism10.0HSD3B2, LHCGR, CYP17A1
42ovarian hyperstimulation syndrome10.0GNRH1, CGB5
43hypoadrenalism10.0POMC
44prolactinoma10.0POMC, GNRH1
45diabetes insipidus10.0POMC
46hyperaldosteronism10.0CYP21A2, CYP17A1, POMC
47essential hypertension10.0INS, RETN, SHBG
48endogenous depression10.0POMC
49klinefelter's syndrome10.0SRD5A1, CYP21A2, IGFL3, SHBG, GNRH1
50bulimia nervosa10.0LSL, MC4R, RETN

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to hyperandrogenism

Clinical Features for Hyperandrogenism

Drugs & Therapeutics for Hyperandrogenism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hyperandrogenism

Drug clinical trials:

Search ClinicalTrials for Hyperandrogenism

Search NIH Clinical Center for Hyperandrogenism

Search CenterWatch for Hyperandrogenism

Genetic Tests for Hyperandrogenism

Anatomical Context for Hyperandrogenism

Sources:
33MalaCards
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MalaCards organs/tissues related to Hyperandrogenism:

33
Whole blood, Cortex, Heart, Adipocyte, Breast, Skin, Ovary, Prostate, B cells, Adrenal cortex, Pituitary

Animal Models for Hyperandrogenism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hyperandrogenism

Sources:
51PubMed
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Articles related to Hyperandrogenism:

(show top 50)    (show all 453)
idTitleAuthorsYear
1
The new policy on hyperandrogenism in elite female athletes is not about "sex testing". (23320653)
2013
2
Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology. (24328568)
2013
3
Cutaneous hyperandrogenism: role of antiandrogen therapy in acne, hirsutism, and androgenetic alopecia. (24358489)
2013
4
Metabolic inflexibility is a feature of women with polycystic ovary syndrome and is associated with both insulin resistance and hyperandrogenism. (23596136)
2013
5
Hyperandrogenism during puberty in the development of polycystic ovary syndrome. (23642453)
2013
6
Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism. (22886405)
2012
7
An unusual cause of hyperandrogenism. (22271814)
2012
8
Hyperandrogenism in adolescent girls. (22846529)
2012
9
AntimA1llerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries. (22541936)
2012
10
Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis. (20518640)
2011
11
Serum adiponectin levels in high school girls with polycystic ovary syndrome and hyperandrogenism. (21190873)
2011
12
Hirsutism score and the severity of hyperandrogenism associated with polycystic ovary syndrome in the southeastern region of Turkey. (21986157)
2011
13
Defining hyperandrogenism in polycystic ovary syndrome: measurement of testosterone and androstenedione by liquid chromatography-tandem mass spectrometry and analysis by receiver operator characteristic plots. (20008514)
2010
14
Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. (20569105)
2010
15
Psychiatric characterization of children with genetic causes of hyperandrogenism. (20807778)
2010
16
Hyperandrogenism in broiler chickens and commercial layers. (18178935)
2008
17
Hyperandrogenism and hyperinsulinism in children of women with polycystic ovary syndrome: a controlled study. (18270257)
2008
18
Evaluating hyperandrogenism: a challenge in acne management. (18561581)
2008
19
Low-dose glucocorticoids in hyperandrogenism. (17628912)
2007
20
Acceleration of luteinizing hormone pulse frequency in adolescent girls with a history of central precocious puberty with versus without hyperandrogenism. (17587857)
2007
21
Functional ovarian hyperandrogenism and polycystic ovary syndrome in prepubertal girls with obesity and/or premature pubarche. (17550211)
2007
22
Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. (16249279)
2006
23
Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome. (16174719)
2005
24
Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. (15292314)
2004
25
Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity. (15070917)
2004
26
Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. (12880121)
2003
27
Acute goserelin administration inhibits gonadotropin and androgen secretion in post-menopausal women with ovarian hyperandrogenism. (12809169)
2003
28
Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism. (12843184)
2003
29
Insulinoma presenting with hyperandrogenism: a case report and a literature review. (12653879)
2003
30
Candidate gene analysis in premature pubarche and adolescent hyperandrogenism. (11287026)
2001
31
The influence of obesity on hyperandrogenism and infertility in the female. (12119994)
2001
32
Hyperinsulinism and its interaction with hyperandrogenism in polycystic ovary syndrome. (10804539)
2000
33
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy. (10587790)
1999
34
Corticotropin-releasing hormone: a potent androgen secretagogue in girls with hyperandrogenism after precocious pubarche. (10599726)
1999
35
Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism. (10221215)
1999
36
Comparison of ovarian electrocautery and oral contraceptives in the treatment of hyperandrogenism in women with polycystic ovary syndrome. (10376864)
1999
37
Ovarian hyperandrogenism is associated with insulin resistance to both peripheral carbohydrate and whole-body protein metabolism in postpubertal young females: a metabolic study. (9626116)
1998
38
Elevated serum progesterone levels during pituitary suppression may signify adrenal hyperandrogenism. (9130909)
1997
39
The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women. (8772557)
1996
40
Peripubertal hyperandrogenism. (8926954)
1996
41
Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. (7671850)
1995
42
Prorenin is elevated in polycystic ovary syndrome and may reflect hyperandrogenism. (7589659)
1995
43
Hyperandrogenism: new insights into etiology, diagnosis, and therapy. (1623148)
1992
44
Ketoconazole use in the treatment of ovarian hyperandrogenism. (2168844)
1990
45
The effect of acute ACTH1-24 loading on the steroid hormone and prolactin content of the blood serum in women with hyperprolactinemia and hyperandrogenism]. (2080142)
1990
46
Hyperinsulinemia and ovarian hyperandrogenism. Cause and effect. (3058472)
1988
47
Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism. (4044776)
1985
48
Acne and hyperandrogenism. (6232296)
1984
49
Ovarian and adrenal vein steroids in patients with nonneoplastic hyperandrogenism: selective catheterization findings. (6233180)
1984
50
Characterization of hyperandrogenism with insulin-resistant diabetes type A. (6245939)
1980

Genetic Variations for Hyperandrogenism

Expression for genes affiliated with Hyperandrogenism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperandrogenism

Search GEO for disease gene expression data for Hyperandrogenism.

Pathways for genes affiliated with Hyperandrogenism

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Hyperandrogenism

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Hyperandrogenism according to GeneCards/GeneDecks:

(show top 50)    (show all 161)
idCompoundScoreTop Affiliating Genes
1estrogen4510.9SRD5A1
2forskolin45 50 1112.7RETN, LHCGR, CYP17A1, POMC
3doca4510.7CYP11A1, HSD3BP4, CYP21A2, CYP17A1, POMC, SRD5A1
4clomiphene citrate4510.7GNRH1, CGB5, IGFBP1, CYP21A2, INS, SHBG
517-hydroxypregnenolone4510.7CYP21A2, CYP17A1, POMC, IGFBP1, SHBG, CGB5
6Pregnenolone11 2411.7HSD3B2, CYP17A1, CYP21A2, CYP11A1
7corticosterone45 60 2412.7LHCGR, MC4R, CYP11A1, CYP21A2, POMC, IGFBP1
8metformin45 50 1112.7LSL, GNRH1, SHBG, IGFBP1, POMC, CYP17A1
9ketoconazole45 29 11 2413.7SRD5A1, CYP11A1, CYP21A2, CYP17A1, POMC, SHBG
1011beta-hydroxysteroid4510.7POMC, CGB5, HSD3BP4, HSD3B2, CYP17A1, CYP21A2
11leuprolide acetate4510.7SHBG, LHCGR, GNRH1, CYP21A2, CGB5
12norepinephrine45 11 2412.7CYP21A2, POMC, CGB5, GNRH1, RETN
1317beta-hydroxysteroid4510.7SRD5A1, CYP11A1, HSD3B2, CGB5, CYP17A1, CYP21A2
14goserelin45 29 1112.7SRD5A1, GNRH1, LSL, SHBG, LHCGR
15progestin4510.7HSD3BP4, LHCGR, GNRH1, CGB5, SHBG, IGFBP1
16dihydrotestosterone45 29 11 2413.7HSD3B2, IGFBP1, GNRH1, CGB5, CYP17A1, CYP21A2
17acth 1-244510.7POMC, CYP17A1, CYP21A2, CYP11A1
18spironolactone50 45 60 29 1114.7SRD5A1, GNRH1, POMC, SHBG, CYP21A2
193beta-hydroxysteroid4510.7CGB5, LHCGR, HSD3BP4, HSD3B2, POMC, CYP17A1
20c-peptide4510.6IGFBP1, SHBG, LSL, CYP21A2, INS, RETN
21estrone45 29 11 2413.6CYP17A1, SHBG, LSL, GNRH1, CGB5, SRD5A1
22thyroxine45 2411.6RETN, CYP21A2, POMC, IGFBP1, GNRH1, INS
23acth4510.6CYP21A2, CYP17A1, POMC, IGFBP1, CGB5, GNRH1
24ribonucleic acid4510.6CYP17A1, IGFBP1, CGB5, CYP21A2, CYP11A1, POMC
25gnrh4510.6CGB5, SHBG, IGFBP1, POMC, CYP17A1, CYP21A2
26cholesterol45 29 11 2413.6HSD3B2, HSD3BP4, LHCGR, CAPN10, LSL, SHBG
27epinephrine45 11 2412.6INS, GNRH1, CYP21A2, POMC, CGB5, SHBG
2817-hydroxyprogesterone45 2411.6POMC, IGFBP1, SHBG, CGB5, GNRH1, HSD3BP4
29dehydroepiandrosterone sulfate4510.6HSD3B2, HSD3BP4, LSL, GNRH1, SHBG, CGB5
30dhea4510.6SRD5A1, INS, RETN, CYP11A1, CYP21A2, CYP17A1
31androstenedione45 2411.6SRD5A1, INS, CYP11A1, CYP21A2, CYP17A1, POMC
32mifepristone45 60 29 1113.6HSD3BP4, IGFBP1, POMC, SHBG, CGB5, GNRH1
33alanine4510.6MC4R, SHBG, LSL, LHCGR, INSL3, INS
34arginine4510.6IGFBP1, SHBG, LSL, GNRH1, POMC, CYP17A1
35leuprolide45 60 29 1113.6GNRH1, LSL, SRD5A1, CGB5
36dexamethasone45 50 29 1113.6HSD3BP4, LSL, GNRH1, CGB5, SHBG, IGFBP1
37hydrocortisone45 2 60 1113.6IGFBP1, LSL, SHBG, POMC, CYP21A2, INS
38estradiol45 11 2412.6GNRH1, POMC, CYP17A1, CYP21A2, CYP11A1, RETN
39diethylstilbestrol45 29 1112.5GNRH1, CGB5, CYP17A1, INSL3, SHBG
40progesterone45 60 29 11 2414.5HSD3BP4, SRD5A1, LHCGR, LSL, GNRH1, CGB5
41steroid4510.5SHBG, INSL3, IGFBP1, POMC, CYP17A1, CYP21A2
42glucose4510.5CYP21A2, LSL, CGB5, POMC
43testosterone45 60 11 2413.5IGFBP1, POMC, CYP17A1, CYP21A2, CYP11A1, RETN
4411 deoxycortisol4510.5SHBG, POMC, CYP17A1, CYP21A2
45rosiglitazone45 50 29 11 2414.5IGFBP1, CYP17A1, SHBG, LSL, RETN, INS
46lipid4510.5CYP17A1, CYP21A2, CYP11A1, MC4R, RETN, SHBG
47valproate4510.4CYP11A1, CYP17A1, IGFBP1, LSL, SHBG
48dihydroprogesterone4510.4HSD3BP4, SRD5A1, CYP11A1, CGB5
49allopregnanolone4510.3SHBG, POMC, GNRH1, SRD5A1
50aminoglutethimide45 1111.1CYP11A1, CYP21A2, POMC, CGB5

GO Terms for genes affiliated with Hyperandrogenism

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperandrogenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.4INS, POMC
2extracellular regionGO:00557610.2WNT4, GNRH1, SHBG, IGFL3, IGFBP1, POMC
3extracellular spaceGO:00561510.0GNRH1, IGFBP1, POMC, RETN, INS, INSL3

Biological processes related to Hyperandrogenism according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00670410.7CYP21A2, CYP17A1, HSD3B2
2sterol metabolic processGO:01612510.7CYP17A1, CYP21A2, CYP11A1
3negative regulation of feeding behaviorGO:200025210.7MC4R, INS
4androgen biosynthetic processGO:00670210.7SRD5A1, WNT4, CYP17A1, HSD3B2
5response to fungicideGO:06099210.7CYP17A1, CYP11A1
6steroid metabolic processGO:00820210.7HSD3B2, CYP17A1, CYP21A2, CYP11A1, SRD5A1
7dibenzo-p-dioxin metabolic processGO:01889410.7CYP17A1, CYP11A1
8biphenyl metabolic processGO:01887910.7CYP17A1, CYP11A1
9cell-cell signalingGO:00726710.6WNT4, INSL3, INS, POMC, GNRH1
10response to insecticideGO:01708510.6CYP17A1, CYP11A1
11phthalate metabolic processGO:01896310.6CYP17A1, CYP11A1
12phenol-containing compound metabolic processGO:01895810.6CYP17A1, CYP11A1
13mineralocorticoid biosynthetic processGO:00670510.6HSD3B2, CYP21A2
14cellular response to antibioticGO:07123610.5CYP17A1, CYP11A1
15sex differentiationGO:00754810.4SRD5A1, CYP17A1
16male gonad developmentGO:00858410.4WNT4, INSL3, LHCGR
17cellular response to gonadotropin stimulusGO:07137110.3LHCGR, CYP17A1
18Leydig cell differentiationGO:03332710.1CYP11A1, CYP17A1

Molecular functions related to Hyperandrogenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:00905510.4SRD5A1, CYP11A1, CYP21A2, CYP17A1
2hormone activityGO:00517910.1INSL3, INS, RETN, POMC, GNRH1

Products for genes affiliated with Hyperandrogenism

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Sources for Hyperandrogenism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet