MCID: HYP043
MIFTS: 51

Hyperandrogenism malady

Endocrine diseases, Reproductive diseases categories
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Summaries for Hyperandrogenism

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Wikipedia:65 Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive levels of... more...

MalaCards based summary: Hyperandrogenism, also known as hyperandrogenization syndrome, is related to acanthosis nigricans and anovulation. An important gene associated with Hyperandrogenism is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cytochrome P450 - arranged by substrate type and Corticotropin-releasing hormone. The compounds 21-Hydroxypregnenolone and 17a,21-Dihydroxypreg-nenolone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Hyperandrogenism

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Hyperandrogenism, Aliases & Descriptions:

Name: Hyperandrogenism 8 10 44 62
Hyperandrogenization Syndrome 8
 
Hyperandrogenisation Syndrome 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


External Ids:

Disease Ontology8 DOID:11613
SNOMED-CT57 237793004
MeSH34 D017588

Related Diseases for Hyperandrogenism

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Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1acanthosis nigricans31.4SHBG, CYP21A2
2anovulation31.3SHBG, CYP21A2
3acne31.3SHBG
4amenorrhea31.2SHBG
5alopecia31.1SHBG
6polycystic ovary syndrome31.0CAPN10, CYP11A1, CYP21A2, SHBG, HSD3B2
7insulin resistance30.9CAPN10, MC4R, SHBG, CYP21A2
8hyperinsulinism30.8MC4R, SHBG
9androgenetic alopecia30.6SHBG, CYP21A2
10adrenal adenoma30.6CYP21A2, CYP11A1
11congenital adrenal hyperplasia30.6HSD3B2, CYP21A2, CYP11A1
12cushing's syndrome30.6CYP21A2
13precocious puberty30.5SHBG, LHCGR, CYP21A2
14leydig cell tumor30.5LHCGR, CYP21A2, CYP11A1
15glucose intolerance30.4CAPN10, SHBG
16obesity30.3CAPN10, CYP21A2, MC4R, CYP11A1, SHBG, INSL3
17diabetes mellitus30.2SHBG, MC4R, CAPN10
18adenoma29.9CYP11A1, CYP21A2, LHCGR, SHBG
19infertility29.8CAPN10, SHBG, LHCGR, INSL3, CYP21A2, CYP11A1
20breast cancer29.3LHCGR, SHBG, CYP11A1, WNT4, CYP21A2
21mullerian aplasia and hyperandrogenism10.5
22klinefelter's syndrome10.3SHBG, CYP21A2
2321-hydroxylase deficiency10.3
24turner syndrome10.3CYP21A2, SHBG
25hypopituitarism10.3SHBG, CYP21A2
26cryptorchidism10.3SHBG, INSL3
27male infertility10.3SHBG, CYP21A2
28ovarian disease10.3
29hair-an syndrome10.3
30autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.3CYP11A1, CYP21A2
31conn's syndrome10.3CYP11A1, CYP21A2
32uterine fibroid10.3SHBG, CYP21A2
33gestational diabetes10.2CAPN10, SHBG
34premature ovarian failure10.2SHBG, CYP11A1
35testicular cancer10.2SHBG, INSL3
36adrenocortical carcinoma10.2CYP21A2, CYP11A1
37adrenal cortical adenoma10.2CYP11A1, CYP21A2
38pseudohermaphroditism10.2LHCGR, HSD3B2
39hypospadias10.2CYP21A2, INSL3, HSD3B2
40graves' disease10.2CYP21A2, SHBG
41hypertension10.2
42type 1 diabetes mellitus10.2
43hyperprolactinemia10.2
44erythrocytosis10.2
45metabolic syndrome x10.1CYP21A2, CAPN10, SHBG
46abrikosov's tumor10.1CYP11A1, LHCGR
47addison's disease10.1HSD3B2, CYP11A1, CYP21A2
48hemangioma10.1
49hepatitis10.1
50sertoli-leydig cell tumor10.1

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to hyperandrogenism

Symptoms for Hyperandrogenism

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Drugs & Therapeutics for Hyperandrogenism

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Drug clinical trials:

Search ClinicalTrials for Hyperandrogenism

Search NIH Clinical Center for Hyperandrogenism

Genetic Tests for Hyperandrogenism

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Anatomical Context for Hyperandrogenism

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MalaCards organs/tissues related to Hyperandrogenism:

32
Ovary, Testes, Bone, Pituitary, Skin, Heart, Prostate, Neutrophil, Cortex, Adipocyte, Breast, Endothelial, Adrenal cortex

Animal Models for Hyperandrogenism or affiliated genes

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MGI Mouse Phenotypes related to Hyperandrogenism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1LHCGR, CYP11A1, INSL3, WNT4, CAPN10
2MP:00053877.6CYP11A1, LHCGR, MC4R, WNT4, CAPN10
3MP:00053897.5WNT4, CYP11A1, INSL3, LHCGR, MC4R
4MP:00053977.3LHCGR, MC4R, WNT4, CAPN10, CYP11A1

Publications for Hyperandrogenism

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Articles related to Hyperandrogenism:

(show top 50)    (show all 565)
idTitleAuthorsYear
1
Induction of Hyperandrogenism in Lean Reproductive-Age Women Stimulates Proatherogenic Inflammation. (25230323)
2014
2
Hyperreactio luteinalis in pregnancy and hyperandrogenism: a case report. (25330696)
2014
3
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. (24680383)
2014
4
Differences in sexual desire between women with clinical versus biochemical signs of hyperandrogenism in polycystic ovarian syndrome. (23127604)
2013
5
Does hyperandrogenism affect the otoacoustic emissions and medial olivocochlear reflex in female adults? (23770686)
2013
6
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
7
Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism. (22886405)
2012
8
Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis. (20518640)
2011
9
Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-KA1ster-Hauser syndrome). (21377155)
2011
10
Serum adiponectin levels in high school girls with polycystic ovary syndrome and hyperandrogenism. (21190873)
2011
11
The frequency of metabolic syndrome is higher among PCOS Brazilian women with menstrual irregularity plus hyperandrogenism. (22096008)
2011
12
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
13
Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty. (19232022)
2009
14
Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. (19832931)
2009
15
Polymorphism in CYP11alpha and CYP17 genes and the etiology of hyperandrogenism in patients with polycystic ovary syndrome]. (18499961)
2008
16
Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndrome. (19209619)
2008
17
Prevalence of nonclassic adrenal hyperplasia (NCAH) in hyperandrogenic women. (18335331)
2008
18
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
19
Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome. (17070182)
2006
20
Oligoanovulation with polycystic ovaries but not overt hyperandrogenism. (16849400)
2006
21
Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. (16263820)
2006
22
The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. (16492701)
2006
23
Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women. (15802316)
2005
24
Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women: the effect of cyproterone acetate-ethinyl estradiol treatment. (15031776)
2004
25
Macroprolactinemia in women presenting with hyperandrogenic symptoms: Implications for the management of polycystic ovary syndrome. (15589886)
2004
26
Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. (12880121)
2003
27
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
28
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate. (11823113)
2002
29
Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism. (12091857)
2002
30
Novel mutations in CYP21 detected in individuals with hyperandrogenism. (12050257)
2002
31
Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (12161545)
2002
32
Hyperandrogenism in adolescents. (11841957)
2002
33
Androgen suppression and clinical improvement with dopamine agonists in hyperandrogenic-hyperprolactinemic women. (11499189)
2001
34
Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women. (11297612)
2001
35
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases. (10891991)
2000
36
Serum levels of inhibins are differentially altered in patients with polycystic ovary syndrome: effects of being overweight and relevance to hyperandrogenism. (10785223)
2000
37
High bone density in hyperandrogenic women: effect of gonadotropin-releasing hormone agonist alone or in conjunction with estrogen-progestin replacement. (8636283)
1996
38
Chronic hyperinsulinemia and the adrenal androgen response to acute corticotropin-(1-24) stimulation in hyperandrogenic women. (7726265)
1995
39
Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman]. (7809540)
1994
40
Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome. (7968591)
1994
41
Defects in beta-cell function in functional ovarian hyperandrogenism. (8496316)
1993
42
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. (8413434)
1993
43
Primary aldosteronism and hyperandrogenism. (1636018)
1992
44
Study of the source(s) of hyperandrogenism in women with idiopathic hirsutism. (2147915)
1990
45
On the origin of the elevated 17-hydroxyprogesterone levels after adrenal stimulation in hyperandrogenism. (2137133)
1990
46
Polycystic ovary syndrome: obesity, insulin resistance, hyperandrogenism. (2700062)
1989
47
The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia. (3192772)
1988
48
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (3305551)
1987
49
The consequences of hyperandrogenism in young women. (3323511)
1987
50
Treatment of severe hirsutism resulting from hyperandrogenism with the reverse sequential cyproterone acetate regimen. (6232380)
1984

Variations for Hyperandrogenism

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Expression for genes affiliated with Hyperandrogenism

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Expression patterns in normal tissues for genes affiliated with Hyperandrogenism

Search GEO for disease gene expression data for Hyperandrogenism.

Pathways for genes affiliated with Hyperandrogenism

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Pathways related to Hyperandrogenism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CYP11A1, CYP21A2
29.2CYP11A1, HSD3B2, CYP21A2
3
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.2CYP11A1, CYP21A2, HSD3B2
4
Show member pathways
9.2CYP21A2, CYP11A1, HSD3B2
58.9HSD3B2, LHCGR, CYP11A1
68.7MC4R, LHCGR, INSL3
7
Show member pathways
8.2INSL3, LHCGR, MC4R, WNT4

Compounds for genes affiliated with Hyperandrogenism

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Compounds related to Hyperandrogenism according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
121-Hydroxypregnenolone2410.1HSD3B2, CYP21A2
217a,21-Dihydroxypreg-nenolone2410.1HSD3B2, CYP21A2
311 deoxycortisol4410.1SHBG, CYP21A2
4Cortexolone2410.1CYP21A2, HSD3B2
5deoxycorticosterone28 2411.0CYP21A2, HSD3B2
6clomiphene citrate4410.0SHBG, CYP21A2
7cortisol28 2411.0CYP21A2, HSD3B2
83-alpha-androstanediol glucuronide44 2411.0SHBG, CYP21A2
9acth 1-244410.0CYP21A2, CYP11A1
10spironolactone44 61 28 50 1113.9CYP21A2, SHBG
11doca449.9CYP21A2, CYP11A1
12aminoglutethimide44 1110.9CYP11A1, CYP21A2
13medroxyprogesterone44 50 28 24 1113.8HSD3B2, CYP11A1
14goserelin44 28 1111.8LHCGR, SHBG
1517-hydroxypregnenolone449.7SHBG, CYP21A2, HSD3B2
16diethylstilbestrol44 28 1111.7INSL3, SHBG
17ketoconazole44 28 24 1112.7SHBG, CYP21A2, CYP11A1
1817a-Hydroxypregnenolone249.6CYP21A2, CYP11A1, HSD3B2
19Pregnenolone24 1110.6CYP21A2, CYP11A1, HSD3B2
20flutamide44 61 1111.6SHBG, LHCGR
2125-hydroxyvitamin d449.6CYP11A1, SHBG
22valproate449.6CYP11A1, SHBG
2311beta-hydroxysteroid449.6HSD3B2, CYP21A2, CYP11A1
2417beta-hydroxysteroid449.6HSD3B2, CYP21A2, CYP11A1
25leuprolide acetate449.6CYP21A2, SHBG, LHCGR
26progestin449.3SHBG, LHCGR, CYP11A1
2717-hydroxyprogesterone44 2410.2CYP11A1, CYP21A2, SHBG, HSD3B2
28dehydroepiandrosterone sulfate449.2CYP11A1, CYP21A2, SHBG, HSD3B2
29dhea449.2CYP21A2, SHBG, HSD3B2, CYP11A1
30androstenedione44 2410.2CYP11A1, HSD3B2, SHBG, CYP21A2
31dihydrotestosterone44 28 24 1112.2HSD3B2, SHBG, CYP11A1, CYP21A2
32ribonucleic acid449.2CYP11A1, LHCGR, CYP21A2
33gnrh449.0SHBG, CYP11A1, CYP21A2, LHCGR
34estradiol44 24 1111.0LHCGR, CYP11A1, CYP21A2, SHBG
35forskolin44 50 1110.9HSD3B2, CYP11A1, CYP21A2, LHCGR
363beta-hydroxysteroid448.7LHCGR, CYP11A1, CYP21A2, INSL3, HSD3B2
37glucose448.6SHBG, CYP21A2, MC4R, CAPN10
38corticosterone44 61 2410.6CYP11A1, CYP21A2, MC4R, LHCGR
39threonine448.6MC4R, INSL3, CYP21A2, LHCGR
40alanine448.5MC4R, INSL3, LHCGR, SHBG
41adenylate448.4MC4R, SHBG, LHCGR, CYP11A1
42lipid448.3CAPN10, CYP11A1, CYP21A2, SHBG, MC4R
43arginine448.3CAPN10, CYP21A2, MC4R, LHCGR, SHBG
44estrogen448.2SHBG, LHCGR, INSL3, CYP11A1, CYP21A2, HSD3B2
45progesterone44 28 61 24 1112.1CYP21A2, LHCGR, WNT4, HSD3B2, SHBG, CYP11A1
46acth447.8CYP11A1, LHCGR, CYP21A2, SHBG, HSD3B2, MC4R
47testosterone44 61 24 1110.8INSL3, WNT4, CYP11A1, CYP21A2, LHCGR, SHBG
48calcium44 50 24 1110.5MC4R, LHCGR, CAPN10, CYP21A2, CYP11A1
49steroid447.5CYP11A1, MC4R, SHBG, LHCGR, INSL3, CYP21A2
50cholesterol44 28 24 1110.4MC4R, LHCGR, SHBG, CYP21A2, HSD3B2, CAPN10

GO Terms for genes affiliated with Hyperandrogenism

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Biological processes related to Hyperandrogenism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mineralocorticoid biosynthetic processGO:0067059.8CYP21A2, HSD3B2
2glucocorticoid biosynthetic processGO:0067049.8CYP21A2, HSD3B2
3sterol metabolic processGO:0161259.5CYP21A2, CYP11A1
4androgen biosynthetic processGO:0067029.5WNT4, HSD3B2
5steroid metabolic processGO:0082029.4CYP11A1, CYP21A2, HSD3B2
6positive regulation of cAMP biosynthetic processGO:0308199.3MC4R, INSL3
7cellular response to transforming growth factor beta stimulusGO:0715609.1WNT4, CYP11A1
8male gonad developmentGO:0085849.1WNT4, INSL3, LHCGR

Products for genes affiliated with Hyperandrogenism

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Sources for Hyperandrogenism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet