MCID: HYP043
MIFTS: 49

Hyperandrogenism malady

Endocrine diseases, Reproductive diseases categories

Summaries for Hyperandrogenism

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive levels of... more...

MalaCards: Hyperandrogenism, also known as hyperandrogenization syndrome, is related to polycystic ovary syndrome and insulin resistance. An important gene associated with Hyperandrogenism is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cytochrome P450 - arranged by substrate type and Corticotropin-releasing hormone. The compounds 21-Hydroxypregnenolone and 17a,21-Dihydroxypreg-nenolone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Hyperandrogenism

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


Aliases & Descriptions:

hyperandrogenism 9 11 46 63
hyperandrogenization syndrome 9


External Ids:

Disease Ontology9 DOID:11613
SNOMED-CT59 237793004
MeSH36 D017588

Related Diseases for Hyperandrogenism

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18GeneCards, 19GeneDecks
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Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.3CAPN10, CYP11A1, CYP21A2, SHBG, HSD3B2
2insulin resistance31.1CAPN10, MC4R, SHBG, CYP21A2
3acanthosis nigricans31.0SHBG, CYP21A2
4anovulation30.9SHBG, CYP21A2
5obesity30.9CAPN10, CYP21A2, MC4R, CYP11A1, SHBG, INSL3
6acne30.7SHBG
7hyperinsulinism30.7MC4R, SHBG
8amenorrhea30.7SHBG
9alopecia30.5SHBG
10congenital adrenal hyperplasia30.5HSD3B2, CYP21A2, CYP11A1
11precocious puberty30.4SHBG, LHCGR, CYP21A2
12diabetes mellitus30.4SHBG, MC4R, CAPN10
13infertility30.3CAPN10, SHBG, LHCGR, INSL3, CYP21A2, CYP11A1
14leydig cell tumor30.3LHCGR, CYP21A2, CYP11A1
15adrenal adenoma30.3CYP11A1, CYP21A2
16glucose intolerance30.2CAPN10, SHBG
17adenoma30.0CYP11A1, CYP21A2, LHCGR, SHBG
18cushing's syndrome30.0CYP21A2
19androgenic alopecia30.0SHBG, CYP21A2
20breast cancer29.7LHCGR, SHBG, CYP11A1, WNT4, CYP21A2
21mullerian aplasia and hyperandrogenism10.5
2221-hydroxylase deficiency10.4
23ovarian disease10.3
24hair-an syndrome10.3
25type 1 diabetes mellitus10.1
26hyperprolactinemia10.1
27hypertension10.1
28erythrocytosis10.1
29klinefelter's syndrome10.1SHBG, CYP21A2
30turner syndrome10.1CYP21A2, SHBG
31hypopituitarism10.1SHBG, CYP21A2
32cryptorchidism10.1SHBG, INSL3
33male infertility10.1SHBG, CYP21A2
34autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.1CYP11A1, CYP21A2
35conn's syndrome10.1CYP11A1, CYP21A2
36uterine fibroid10.1SHBG, CYP21A2
37biliary atresia10.1
38hemangioma10.1
39hepatitis10.1
40prostatitis10.1
41central precocious puberty10.1
42cortisone reductase deficiency 110.1
43gestational diabetes10.1CAPN10, SHBG
44premature ovarian failure10.1SHBG, CYP11A1
45testicular cancer10.0SHBG, INSL3
46adrenocortical carcinoma10.0CYP21A2, CYP11A1
47pseudohermaphroditism10.0LHCGR, HSD3B2
48hypospadias10.0CYP21A2, INSL3, HSD3B2
49graves' disease10.0CYP21A2, SHBG
50metabolic syndrome x10.0CYP21A2, CAPN10, SHBG

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to hyperandrogenism

Symptoms for Hyperandrogenism

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Drugs & Therapeutics for Hyperandrogenism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hyperandrogenism

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Anatomical Context for Hyperandrogenism

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34MalaCards
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MalaCards organs/tissues related to Hyperandrogenism:

34
Ovary, Testes, Bone, Pituitary, Skin, Heart, Prostate, Adipocyte, Cortex, Endothelial, Breast, Adrenal cortex

Animal Models for Hyperandrogenism or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hyperandrogenism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1LHCGR, CYP11A1, INSL3, WNT4, CAPN10
2MP:00053877.6CYP11A1, LHCGR, MC4R, WNT4, CAPN10
3MP:00053897.5WNT4, CYP11A1, INSL3, LHCGR, MC4R
4MP:00053977.3LHCGR, MC4R, WNT4, CAPN10, CYP11A1

Publications for Hyperandrogenism

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53PubMed
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Articles related to Hyperandrogenism:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Differences in sexual desire between women with clinical versus biochemical signs of hyperandrogenism in polycystic ovarian syndrome. (23127604)
2013
2
Does hyperandrogenism affect the otoacoustic emissions and medial olivocochlear reflex in female adults? (23770686)
2013
3
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
4
Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism. (22886405)
2012
5
Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis. (20518640)
2011
6
Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-KA1ster-Hauser syndrome). (21377155)
2011
7
Serum adiponectin levels in high school girls with polycystic ovary syndrome and hyperandrogenism. (21190873)
2011
8
The frequency of metabolic syndrome is higher among PCOS Brazilian women with menstrual irregularity plus hyperandrogenism. (22096008)
2011
9
Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (20378617)
2010
10
Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty. (19232022)
2009
11
Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. (19832931)
2009
12
Polymorphism in CYP11alpha and CYP17 genes and the etiology of hyperandrogenism in patients with polycystic ovary syndrome]. (18499961)
2008
13
Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndrome. (19209619)
2008
14
Prevalence of nonclassic adrenal hyperplasia (NCAH) in hyperandrogenic women. (18335331)
2008
15
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
16
Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome. (17070182)
2006
17
Oligoanovulation with polycystic ovaries but not overt hyperandrogenism. (16849400)
2006
18
Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. (16263820)
2006
19
The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. (16492701)
2006
20
Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women. (15802316)
2005
21
Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women: the effect of cyproterone acetate-ethinyl estradiol treatment. (15031776)
2004
22
Macroprolactinemia in women presenting with hyperandrogenic symptoms: Implications for the management of polycystic ovary syndrome. (15589886)
2004
23
Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. (12880121)
2003
24
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
25
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate. (11823113)
2002
26
Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism. (12091857)
2002
27
Novel mutations in CYP21 detected in individuals with hyperandrogenism. (12050257)
2002
28
Hyperandrogenism in adolescents. (11841957)
2002
29
Androgen suppression and clinical improvement with dopamine agonists in hyperandrogenic-hyperprolactinemic women. (11499189)
2001
30
Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women. (11297612)
2001
31
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases. (10891991)
2000
32
Serum levels of inhibins are differentially altered in patients with polycystic ovary syndrome: effects of being overweight and relevance to hyperandrogenism. (10785223)
2000
33
High bone density in hyperandrogenic women: effect of gonadotropin-releasing hormone agonist alone or in conjunction with estrogen-progestin replacement. (8636283)
1996
34
Chronic hyperinsulinemia and the adrenal androgen response to acute corticotropin-(1-24) stimulation in hyperandrogenic women. (7726265)
1995
35
Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. (7671850)
1995
36
Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman]. (7809540)
1994
37
Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome. (7968591)
1994
38
Clinical and endocrine effects of flutamide in hyperandrogenic women. (8224265)
1993
39
Defects in beta-cell function in functional ovarian hyperandrogenism. (8496316)
1993
40
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. (8413434)
1993
41
Primary aldosteronism and hyperandrogenism. (1636018)
1992
42
Study of the source(s) of hyperandrogenism in women with idiopathic hirsutism. (2147915)
1990
43
On the origin of the elevated 17-hydroxyprogesterone levels after adrenal stimulation in hyperandrogenism. (2137133)
1990
44
Polycystic ovary syndrome: obesity, insulin resistance, hyperandrogenism. (2700062)
1989
45
The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia. (3192772)
1988
46
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (3305551)
1987
47
The consequences of hyperandrogenism in young women. (3323511)
1987
48
Treatment of severe hirsutism resulting from hyperandrogenism with the reverse sequential cyproterone acetate regimen. (6232380)
1984
49
Acne and hyperandrogenism. (6232296)
1984
50
Plasma and salivary androstenedione and dihydrotestosterone in women with hyperandrogenism. (6223726)
1983

Variations for Hyperandrogenism

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Expression for genes affiliated with Hyperandrogenism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperandrogenism

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Pathways for genes affiliated with Hyperandrogenism

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 61Thomson Reuters, 31KEGG
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Pathways related to Hyperandrogenism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CYP11A1, CYP21A2
29.2CYP11A1, HSD3B2, CYP21A2
3
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
9.2CYP11A1, CYP21A2, HSD3B2
4
Show member pathways
9.2CYP21A2, CYP11A1, HSD3B2
58.9HSD3B2, LHCGR, CYP11A1
68.7MC4R, LHCGR, INSL3
7
Show member pathways
8.2INSL3, LHCGR, MC4R, WNT4

Compounds for genes affiliated with Hyperandrogenism

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25HMDB, 46Novoseek, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 12DrugBank
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Compounds related to Hyperandrogenism according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
121-Hydroxypregnenolone2510.1HSD3B2, CYP21A2
217a,21-Dihydroxypreg-nenolone2510.1HSD3B2, CYP21A2
311 deoxycortisol4610.1SHBG, CYP21A2
4Cortexolone2510.1CYP21A2, HSD3B2
5deoxycorticosterone30 2511.0CYP21A2, HSD3B2
6clomiphene citrate4610.0SHBG, CYP21A2
7cortisol30 2511.0CYP21A2, HSD3B2
83-alpha-androstanediol glucuronide46 2511.0SHBG, CYP21A2
9acth 1-244610.0CYP21A2, CYP11A1
10spironolactone46 62 30 52 1213.9CYP21A2, SHBG
11doca469.9CYP21A2, CYP11A1
12aminoglutethimide46 1210.9CYP11A1, CYP21A2
13medroxyprogesterone46 52 30 25 1213.8HSD3B2, CYP11A1
14goserelin46 30 1211.8LHCGR, SHBG
1517-hydroxypregnenolone469.7SHBG, CYP21A2, HSD3B2
16diethylstilbestrol46 30 1211.7INSL3, SHBG
17ketoconazole46 30 25 1212.7SHBG, CYP21A2, CYP11A1
1817a-Hydroxypregnenolone259.6CYP21A2, CYP11A1, HSD3B2
19Pregnenolone25 1210.6CYP21A2, CYP11A1, HSD3B2
20flutamide46 62 1211.6SHBG, LHCGR
2125-hydroxyvitamin d469.6CYP11A1, SHBG
22valproate469.6CYP11A1, SHBG
2311beta-hydroxysteroid469.6HSD3B2, CYP21A2, CYP11A1
2417beta-hydroxysteroid469.6HSD3B2, CYP21A2, CYP11A1
25leuprolide acetate469.6CYP21A2, SHBG, LHCGR
26progestin469.3SHBG, LHCGR, CYP11A1
2717-hydroxyprogesterone46 2510.2CYP11A1, CYP21A2, SHBG, HSD3B2
28dehydroepiandrosterone sulfate469.2CYP11A1, CYP21A2, SHBG, HSD3B2
29dhea469.2CYP21A2, SHBG, HSD3B2, CYP11A1
30androstenedione46 2510.2CYP11A1, HSD3B2, SHBG, CYP21A2
31dihydrotestosterone46 30 25 1212.2HSD3B2, SHBG, CYP11A1, CYP21A2
32ribonucleic acid469.2CYP11A1, LHCGR, CYP21A2
33gnrh469.0SHBG, CYP11A1, CYP21A2, LHCGR
34estradiol46 25 1211.0LHCGR, CYP11A1, CYP21A2, SHBG
35forskolin46 52 1210.9HSD3B2, CYP11A1, CYP21A2, LHCGR
363beta-hydroxysteroid468.7LHCGR, CYP11A1, CYP21A2, INSL3, HSD3B2
37glucose468.6SHBG, CYP21A2, MC4R, CAPN10
38corticosterone46 62 2510.6CYP11A1, CYP21A2, MC4R, LHCGR
39threonine468.6MC4R, INSL3, CYP21A2, LHCGR
40alanine468.5MC4R, INSL3, LHCGR, SHBG
41adenylate468.4MC4R, SHBG, LHCGR, CYP11A1
42lipid468.3CAPN10, CYP11A1, CYP21A2, SHBG, MC4R
43arginine468.3CAPN10, CYP21A2, MC4R, LHCGR, SHBG
44estrogen468.2SHBG, LHCGR, INSL3, CYP11A1, CYP21A2, HSD3B2
45progesterone46 30 62 25 1212.1CYP21A2, LHCGR, WNT4, HSD3B2, SHBG, CYP11A1
46acth467.8CYP11A1, LHCGR, CYP21A2, SHBG, HSD3B2, MC4R
47testosterone46 62 25 1210.8INSL3, WNT4, CYP11A1, CYP21A2, LHCGR, SHBG
48calcium46 52 25 1210.5MC4R, LHCGR, CAPN10, CYP21A2, CYP11A1
49steroid467.5CYP11A1, MC4R, SHBG, LHCGR, INSL3, CYP21A2
50cholesterol46 30 25 1210.4MC4R, LHCGR, SHBG, CYP21A2, HSD3B2, CAPN10

GO Terms for genes affiliated with Hyperandrogenism

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17Gene Ontology
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Biological processes related to Hyperandrogenism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mineralocorticoid biosynthetic processGO:0067059.8CYP21A2, HSD3B2
2glucocorticoid biosynthetic processGO:0067049.8CYP21A2, HSD3B2
3sterol metabolic processGO:0161259.5CYP21A2, CYP11A1
4androgen biosynthetic processGO:0067029.5WNT4, HSD3B2
5steroid metabolic processGO:0082029.4CYP11A1, CYP21A2, HSD3B2
6positive regulation of cAMP biosynthetic processGO:0308199.3MC4R, INSL3
7cellular response to transforming growth factor beta stimulusGO:0715609.1WNT4, CYP11A1
8male gonad developmentGO:0085849.1WNT4, INSL3, LHCGR

Products for genes affiliated with Hyperandrogenism

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Sources for Hyperandrogenism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet