MCID: HYP004
MIFTS: 57

Hypercalcemia malady

Genetic diseases, Nephrological diseases, Endocrine diseases, Rare diseases categories

Aliases & Classifications for Hypercalcemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 22GTR, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt
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Hypercalcemia, Aliases & Descriptions:

Name: Hypercalcemia 9 11 43 22 60


Classifications:



External Ids:

Disease Ontology9 DOID:12678
ICD9CM27 275.42
MeSH33 D006934
NCIt38 C3112

Summaries for Hypercalcemia

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MalaCards based summary: Hypercalcemia is related to nephrocalcinosis and williams-beuren syndrome. An important gene associated with Hypercalcemia is CASR (calcium-sensing receptor), and among its related pathways are Endocrine and other factor-regulated calcium reabsorption and superpathway of cholesterol biosynthesis. The drugs calcitonin and edetic acid, disodium salt and the compounds 22-oxacalcitriol and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related mouse phenotypes are other and craniofacial.

Related Diseases for Hypercalcemia

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Diseases in the Hypercalcemia family:

Hypercalcemia, Infantile Autosomal Recessive Infantile Hypercalcemia

Diseases related to Hypercalcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 331)
idRelated DiseaseScoreTop Affiliating Genes
1nephrocalcinosis31.0NR1I3, CASR
2williams-beuren syndrome30.9CYP27B1
3parathyroid adenoma30.9PTHLH, CASR, ALPL
4paraneoplastic syndromes30.6PTHLH, FGF23
5hyperparathyroidism, neonatal30.4NR1I3, CASR
6osteoporosis30.3CYP27B1, PTHLH
7hyperphosphatemia30.3FGF23, ALPL, CASR
8hyperparathyroidism30.2CYP27B1, PTHLH, CASR, ALPL, NR1I3, FGF23
9hypervitaminosis d30.2FGF23, CYP27B1
10parathyroid gland disease30.2CASR, PTHLH
11osteitis fibrosa30.1ALPL, CASR
12breast cancer30.1PTHLH, PTH1R, CYP24A1, CYP27B1
13renal osteodystrophy30.0CASR, ALPL, FGF23
14calcinosis30.0CASR, ALPL, FGF23
15primary hyperparathyroidism30.0CYP27B1, FGF23, NR1I3, CASR, PTHLH, PTH1R
16graves' disease29.9FGF23, CASR, CYP27B1
17hypoparathyroidism29.9PTH1R, PTHLH, CASR, NR1I3, FGF23
18pseudohypoparathyroidism29.9GNA11, PTH1R, PTHLH
19nephrolithiasis29.8CASR, NR1I3, FGF23
20hyperthyroidism29.8ALPL, FGF23
21hypophosphatemia29.8FGF23, ALPL, PTHLH, CYP27B1
22fibrous dysplasia29.7GNA11, ALPL, FGF23
23prostate cancer29.3ALPL, CASR, PTHLH, PTH1R, CYP24A1, CYP27B1
24primary hyperoxaluria28.9CYP27B1, CYP24A1, CASR, NR1I3, FGF23
25osteomalacia28.6PTH1R, CYP24A1, CYP27B1, PTHLH, CASR, ALPL
26familial hypocalciuric hypercalcemia10.8
27leukemia10.7
28pancreatitis10.5
29hypocalciuric hypercalcemia, familial, type iii10.5
30hypocalciuric hypercalcemia, type i10.5
31parathyroid carcinoma10.5
32adenocarcinoma10.5
33adenoma10.5
34hypocalciuric hypercalcemia, type ii10.4
35ollier disease10.4PTHLH
36t-cell leukemia10.4
37adult t-cell leukemia10.3
38leydig cell tumor10.3
39lymphoblastic leukemia10.3
40myeloma10.3
41thyroiditis10.3
42hypercalcemia, infantile10.3
43dysgerminoma10.3
44renal cell carcinoma10.3
45multiple myeloma10.3
46hypervitaminosis a10.3
47tuberculosis10.3
48lung cancer10.3
49b-cell lymphomas10.3
50mccune-albright syndrome, somatic, mosaic10.3FGF23

Graphical network of the top 20 diseases related to Hypercalcemia:



Diseases related to hypercalcemia

Symptoms for Hypercalcemia

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Drugs & Therapeutics for Hypercalcemia

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Genetic Tests for Hypercalcemia

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Genetic tests related to Hypercalcemia:

id Genetic test Affiliating Genes
1 Hypercalcemia22

Anatomical Context for Hypercalcemia

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MalaCards organs/tissues related to Hypercalcemia:

31
Bone, Kidney, Lung, T cells, Breast, B cells, Thyroid, Ovary, Colon, Liver, Prostate, Pancreas, Bone marrow, Myeloid, Pituitary, Endothelial, Tongue, Eye, Lymph node, Thymus, Heart, Skin, Testis, Testes, B lymphoblasts, Pancreatic islet

Animal Models for Hypercalcemia or affiliated genes

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Publications for Hypercalcemia

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Articles related to Hypercalcemia:

(show top 50)    (show all 1206)
idTitleAuthorsYear
1
Differentiating familial hypocalciuric hypercalcemia from primary hyperparathyroidism. (23425644)
2013
2
Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia. (24377594)
2013
3
Sarcoidosis in a chronic dialysis patient diagnosed by sarcoidosis-related hypercalcemia with no common systemic clinical manifestations: a case report and review of the literature. (24292755)
2013
4
Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma. (22534085)
2013
5
An unusual case of malignancy-related hypercalcemia. (24353437)
2013
6
Hypercalcemia and osteolytic lesions as presenting symptoms of acute lymphoblastic leukemia in childhood. The use of zoledronic acid and review of the literature. (23934636)
2013
7
Hypercalcemia in children receiving pharmacologic doses of vitamin D. (22412034)
2012
8
Mirror, mirror on the wall: hypercalcemia as a consequence of modern cosmetic treatment with liquid silicone. (22293885)
2012
9
Primary hyperparathyroidism and familial hypocalciuric hypercalcemia: relationships and clinical implications. (22232026)
2012
10
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. (23087723)
2012
11
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. (22937283)
2011
12
Flare hypercalcemia after letrozole in a patient with liver metastasis from breast cancer: a case report. (21970715)
2011
13
Forearm bone mineral density in familial hypocalciuric hypercalcemia and primary hyperparathyroidism: a comparative study. (21785908)
2011
14
Hypercalcemia and soft tissue calcification owing to sarcoidosis: the sunlight-cola connection. (20200968)
2010
15
A case of ovarian cancer associated with hypercalcemia. (18845526)
2008
16
Active crohn disease and hypercalcemia treated with infliximab: case report and literature review. (18238746)
2008
17
Idiopathic infantile hypercalcemia and renal involvement. (17978858)
2008
18
Commentary on 'Pamidronate: treatment for severe hypercalcemia in neonatal subcutaneous fat necrosis' by Alos N. et al., Hormone Research 2006;65:289-294. (18772600)
2008
19
An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations. (17372216)
2007
20
Prevalence of hypercalcemia in hospitalised patients: effects of "correction" for serum albumin values. (16075918)
2005
21
Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia. (15715044)
2005
22
Hypercalcemia in prostate cancer with positive neuron-specific enolase stain. (15354984)
2004
23
An elderly case of non-Hodgkin's lymphoma (NHL) with hypercalcemia]. (12708052)
2003
24
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
25
Congenital sucrase-isomaltase deficiency presenting with failure to thrive, hypercalcemia, and nephrocalcinosis. (12014995)
2002
26
Hypercalcemia due to immobilization in critically ill children: calcitnonin treatment]. (11412402)
2001
27
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
28
Hypercalcemia induced with the plasma levels of parathyroid hormone-related peptide in multiple myeloma. (11030205)
2000
29
Hypercalcemia in neonatal distal renal tubular acidosis. (10775085)
2000
30
Serum levels of carboxyterminal propeptide of type I procollagen (PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP) and carboxyterminal parathyroid hormone-related protein (C-PTHrP) in hematological malignancies with bone lesions and hypercalcemia]. (9597894)
1998
31
Hypercalcemia due to endogenous overproduction of active vitamin D in identical twins with cat-scratch disease. (9480364)
1998
32
Significance of parathyroid hormone-related protein as a factor stimulating bone resorption and causing hypercalcemia in myeloma. (9766803)
1998
33
Role of Parathyroid Hormone Related Peptide (PTHrP) in Hypercalcemia of Malignancy and the Development of Osteolytic Metastases. (19078166)
1997
34
Hypercalcemia associated with all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. (8501972)
1993
35
Osseous and intestinal compartments in the humoral hypercalcemia of malignancy associated to Walker 256 tumor in rats. (8451038)
1993
36
Increased 1,25-(OH)2D2 concentration in a patient with malignancy-associated hypercalcemia receiving intravenous hyperalimentation inadvertently supplemented with vitamin D2. (8012094)
1993
37
Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamous carcinoma. (8428354)
1993
38
NMR solution structure of the [Ala26]parathyroid-hormone-related protein(1-34) expressed in humoral hypercalcemia of malignancy. (8425530)
1993
39
Plasma intact parathyroid hormone (PTH) and PTH-related peptide in familial benign hypercalcemia: greater responsiveness to endogenous PTH than in primary hyperparathyroidism. (1997510)
1991
40
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. (1999505)
1991
41
Intravenous pamidronic acid in hypercalcemia due to parathyroid carcinoma. (1820495)
1991
42
A case of pheochromocytoma producing parathyroid hormone-related protein and presenting with hypercalcemia. (2347892)
1990
43
Nephrocalcinosis, hypercalcemia, sarcoidosis or primary hyperparathyroidism? (3983783)
1985
44
Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy. (6546543)
1984
45
Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy. (6577602)
1983
46
Hypophosphatemia-induced hypercalcemia during acute renal failure. (6671351)
1983
47
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. (6298791)
1983
48
Familial hypocalciuric hypercalcemia: the relation to primary parathyroid hyperplasia. (7045673)
1982
49
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
50
Hypercalcemia and head and neck cancer. Bony metastases from tongue cancer. (697640)
1978

Variations for Hypercalcemia

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Expression for genes affiliated with Hypercalcemia

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Search GEO for disease gene expression data for Hypercalcemia.

Pathways for genes affiliated with Hypercalcemia

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Pathways related to Hypercalcemia according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AP2S1, PTH1R
2
Show member pathways
Cholesterol biosynthesis36
lanosterol biosynthesis36
zymosterol biosynthesis36
mevalonate pathway I36
epoxysqualene biosynthesis36
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)36
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)36
trans, trans-farnesyl diphosphate biosynthesis36
cholesterol biosynthesis I36
cholesterol biosynthesis III (via desmosterol)36
geranylgeranyldiphosphate biosynthesis36
9.3CYP24A1, CYP27B1
3
Show member pathways
9.3CYP24A1, CYP27B1
49.3CYP24A1, CYP27B1
59.3PTHLH, PTH1R, GNA11
6
Show member pathways
9.3GNA11, PTH1R, PTHLH
79.2ALPL, PTHLH, PTH1R
89.1FGF23, PTH1R
98.9NR1I3, CYP24A1, CYP27B1
108.8CYP27B1, CYP24A1, PTH1R
11
Show member pathways
7.8GNA11, PTH1R, PTHLH, AP2S1, CASR, FGF23

Compounds for genes affiliated with Hypercalcemia

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Compounds related to Hypercalcemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
122-oxacalcitriol4310.2PTHLH, CASR
2pamidronate43 49 1212.1PTHLH, CASR
3gadolinium4310.1CASR, NR1I3
4cinacalcet43 28 1212.0CASR, NR1I3
5l-tryptophan49 28 43 24 1214.0NR1I3, CASR
6l-amino acid4310.0NR1I3, CASR
7calcifediol599.8CYP27B1, NR1I3
8Propyl alcohol249.8ALPL, NR1I3
9Isopropyl alcohol249.8ALPL, NR1I3
10Ercalcitriol249.7CYP24A1, CYP27B1
11sevelamer439.7CASR, FGF23
12Calcidiol24 1210.7CYP27B1, CYP24A1
13neomycin439.7NR1I3, CASR, PTHLH
141-Hexanol249.7NR1I3, ALPL
15Ergocalciferol24 1210.7CYP24A1, CYP27B1
16Vitamin D3249.7CYP27B1, CYP24A1
17paricalcitol43 1210.7CYP27B1, CYP24A1
181-Pentanol249.7NR1I3, ALPL
1924,25-dihydroxyvitamin d3439.7CYP27B1, CYP24A1
20Isobutanol249.6NR1I3, ALPL
21inositol 1,4,5 trisphosphate439.5NR1I3, CASR, PTH1R
221-Butanol249.5NR1I3, ALPL
23ketoconazole43 28 24 1212.3CYP24A1, CYP27B1
24alfacalcidol43 59 1211.3CYP27B1, CYP24A1, NR1I3
25calcipotriol43 59 28 1212.3NR1I3, CYP24A1, CYP27B1
26magnesium43 24 1211.2PTHLH, CASR, ALPL, NR1I3
27ribonucleic acid439.2NR1I3, CASR, PTHLH, PTH1R
28clotrimazole28 43 24 1212.1NR1I3, CYP27B1
29lysine439.1NR1I3, CASR, PTHLH, CYP27B1
30alanine439.0PTH1R, PTHLH, CASR, NR1I3
31hydrogen43 2410.0CYP27B1, PTH1R, PTHLH, CASR
32hydroxyapatite439.0FGF23, ALPL, CASR, PTHLH
33eb 108943 599.9CYP27B1, CYP24A1, PTHLH, NR1I3
34dexamethasone43 49 28 1211.9NR1I3, PTHLH, PTH1R, CYP24A1
35phenylalanine438.9CASR, ALPL, NR1I3, FGF23
36arginine438.8PTHLH, CASR, NR1I3, FGF23
37forskolin43 49 1210.6CYP27B1, CYP24A1, PTH1R, PTHLH, CASR
38pge2438.6CYP27B1, CYP24A1, PTH1R, PTHLH, CASR
39steroid438.4CYP27B1, CYP24A1, PTH1R, PTHLH, NR1I3
40serine438.3PTH1R, PTHLH, CASR, NR1I3, FGF23
4125-hydroxyvitamin d438.3CYP27B1, CYP24A1, PTHLH, CASR, FGF23
42tyrosine438.1CYP27B1, PTHLH, CASR, NR1I3, FGF23
43cyclic amp43 249.1NR1I3, CASR, PTHLH, PTH1R, CYP24A1, CYP27B1
44estrogen438.1CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, NR1I3
45retinoic acid43 249.0CYP27B1, CYP24A1, PTH1R, PTHLH, ALPL, NR1I3
46phosphorus437.8CYP27B1, PTH1R, PTHLH, CASR, NR1I3, FGF23
471,25 dihydroxy vitamin d3437.3CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, NR1I3
48calcitriol43 59 24 1210.3CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, NR1I3
49vitamin d436.9FGF23, CYP27B1, NR1I3, ALPL, CASR, PTHLH
50calcium43 49 24 129.9CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, ALPL

GO Terms for genes affiliated with Hypercalcemia

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Biological processes related to Hypercalcemia according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endochondral ossificationGO:00019589.8ALPL, PTHLH
2osteoblast developmentGO:00020769.7PTH1R, PTHLH
3adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00071889.6PTH1R, GNA11
4vitamin D metabolic processGO:00423599.5CYP24A1, CYP27B1
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.5PTH1R, PTHLH
6bone mineralizationGO:00302829.4PTH1R, CYP27B1
7steroid metabolic processGO:00082029.3CYP24A1, CYP27B1
8positive regulation of vitamin D 24-hydroxylase activityGO:00109809.2FGF23, CYP27B1
9response to vitamin DGO:00332809.2ALPL, CYP24A1, CYP27B1
10skeletal system developmentGO:00015019.1GNA11, PTH1R, PTHLH, ALPL
11vitamin D catabolic processGO:00423698.8FGF23, CYP24A1, CYP27B1
12negative regulation of cell proliferationGO:00082858.7PTHLH, PTH1R, CYP27B1

Products for genes affiliated with Hypercalcemia

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Sources for Hypercalcemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet