MCID: HYP004
MIFTS: 69

Hypercalcemia malady

Summaries for Hypercalcemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hypercalcaemia (British English) or hypercalcemia (American English) is an elevated calcium (Ca2+) level... more...

MalaCards: Hypercalcemia, also known as hypercalcinemia, is related to primary hyperparathyroidism and parathyroid carcinoma. An important gene associated with Hypercalcemia is CASR (calcium-sensing receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs calcitonin and edetic acid, disodium salt and the compounds vitamin d and 25-hydroxyvitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and thymus, and related mouse phenotypes are growth/size and skeleton.

Aliases & Classifications for Hypercalcemia

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
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Aliases & Descriptions:

hypercalcemia 8 22 10 45 61
hypercalcinemia 8
hypercalcaemia 8


External Ids:

Disease Ontology8 DOID:12678
ICD9CM27 275.42
NCIt40 C3112
MeSH35 D006934

Related Diseases for Hypercalcemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypercalcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 334)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperparathyroidism31.0PTH, PTHLH, PTH1R, CXADR, FGF23, CYP27B1
2parathyroid carcinoma30.9CASR, PTH
3hyperparathyroidism, neonatal30.6CASR, PRKAR1A, NR1I3, CXADR
4adenocarcinoma30.6CASR, TNFSF11, CYP27B1, CXADR, PTHLH
5adenoma30.6CALCA, CASR, PRKAR1A, NR1I3, CXADR, PTH
6nephrocalcinosis30.6NR1I3, CASR
7dysgerminoma30.4PTHLH
8hypoparathyroidism30.4PRKAR1A, CASR, CALCA, NR1I3, FGF23, CXADR
9hyperphosphatemia30.3ALPL, PTH, FGF23, CASR
10paraneoplastic syndromes30.3PTHLH, FGF23
11bone carcinoma30.2PTHLH, TNFSF11, TNFRSF11A
12hypophosphatasia30.2ALPL
13osteoporosis30.1PTHLH, PTH1R, CXADR, FGF23, CYP27B1, CYP24A1
14hypophosphatemia30.1ALPL, PTH, PTHLH, FGF23, CYP27B1, CALCA
15renal osteodystrophy30.0CALCA, CASR, FGF23, PTH, ALPL
16thyroiditis30.0CALCA
17hypocalcemia, autosomal dominant30.0CASR, PRKAR1A, CXADR
18multiple endocrine neoplasia30.0CALCA, PRKAR1A
19cushing's syndrome30.0AVPR2, PRKAR1A, CALCA
20osteopetrosis30.0TNFSF11, TNFRSF11A
21graves' disease30.0CASR, CYP27B1, FGF23
22osteomalacia29.9ALPL, PTH, PTHLH, PTH1R, FGF23, CYP27B1
23nephrolithiasis29.9CASR, NR1I3, FGF23, PTH
24osteoporosis, postmenopausal29.9CALCA, TNFRSF11A, TNFSF11, CYP27B1, PTHLH, PTH
25diabetes insipidus29.9AVPR2
26rickets29.8PTH, CYP27B1, CASR
27osteitis fibrosa29.7CASR, PTH, ALPL
28paget disease, juvenile29.7TNFSF11, TNFRSF11A, CALCA
29fibrous dysplasia29.7FGF23, ALPL
30hypervitaminosis d29.7CYP27B1, FGF23
31thyroid cancer29.6PTH, PRKAR1A, CALCA
32wermer syndrome29.6PTH, PRKAR1A, CASR
33thyroid medullary carcinoma29.6PRKAR1A, CASR, CALCA
34primary hyperoxaluria29.6CALCA, PTH, ALPL
35pheochromocytoma29.6STC1, CALCA
36acromegaly29.6PRKAR1A
37familial hypocalciuric hypercalcemia10.8
38squamous cell carcinoma10.6
39acute leukemia10.5
40hypercalcemia, infantile10.4
41familial hypocalciuric hypercalcemia type 310.4
42williams syndrome10.4
43familial hypocalciuric hypercalcemia type 110.4
44familial hypocalciuric hypercalcemia type 210.3
45n syndrome10.3
46hypocalciuric hypercalcemia, type i10.3
47tuberculosis10.3
48adenosquamous carcinoma10.2
49small cell carcinoma10.2
50bone lymphoma10.2

Graphical network of the top 20 diseases related to Hypercalcemia:



Diseases related to hypercalcemia

Clinical Features for Hypercalcemia

Drugs & Therapeutics for Hypercalcemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Hypercalcemia

Sources:
22GTR
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Genetic tests related to Hypercalcemia:

id Genetic test Affiliating Genes
1 Hypercalcemia22

Anatomical Context for Hypercalcemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypercalcemia:

33
Bone marrow, Lymph node, Thymus, Heart, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Ovary, Prostate, Testis, Myeloid, T cells, B lymphoblasts, B cells, Endothelial, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Pituitary, Testis leydig

Animal Models for Hypercalcemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypercalcemia

Sources:
51PubMed
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Articles related to Hypercalcemia:

(show top 50)    (show all 1160)
idTitleAuthorsYear
1
Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia. (24377594)
2013
2
Severe hypercalcemia after a single high dose of vitamin D in a patient with sarcoidosis. (22955801)
2013
3
Diabetes due to recurrent pancreatitis secondary to hypercalcemia due to primary hyperparathyroidism. (24251162)
2013
4
Challenges in the differential diagnosis of hypercalcemia: A case of hypercalcemia with normal PTH level. (22247823)
2012
5
A Case of Carcinoid Tumor-Associated Hypercalcemia. (22493603)
2012
6
Altered mental status and hematemesis in a child with hypercalcemia. (22391928)
2012
7
Pancreatitis due to hypercalcemia in a young adult. (22675849)
2012
8
Quiz case: a 19-year-old woman with hypercalcemia and abdominal pain. (22414978)
2012
9
Pulmonary calciphylaxis associated with acute respiratory and renal failure due to cryptogenic hypercalcemia: an autopsy case report. (23323114)
2012
10
Hypercalcemia and refractory peritonitis alert the condition of tuberculous peritonitis: a case report and review literature. (22043583)
2011
11
The relative role of fibroblast growth factor 23 and parathyroid hormone in predicting future hypophosphatemia and hypercalcemia after living donor kidney transplantation: a 1-year prospective observational study. (21303965)
2011
12
A case of hypercalcemia and scabies. (20362741)
2010
13
Hypercalcemia-leukocytosis syndrome in a patient with cavitating squamous cell carcinoma of the lung. (19183491)
2009
14
Hypercalcemia and treated breast cancers: the diagnostic dilemma. (19293490)
2009
15
Paget's disease and hypercalcemia: coincidence or causal relationship?]. (20073401)
2009
16
Childhood aleukemic leukemia with hypercalcemia and bone lesions mimicking metabolic bone disease. (19618667)
2009
17
Symptomatic hypercalcemia in a patient with chronic tophaceous gout: a case report. (18687121)
2008
18
Juvenile granulosa cell tumor of the ovary associated with hypercalcemia. (17849133)
2008
19
Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection. (17579046)
2007
20
Successful palliation of hypercalcemia secondary to metastatic parathyroid cancer: an unusual indication for hepatic resection. (17653642)
2007
21
Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia. (15715044)
2005
22
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
23
A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. (12519831)
2003
24
Increased fibroblast growth factor-like autoantibodies in serum from a subset of patients with cancer-associated hypercalcemia. (12384179)
2002
25
Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. (11781248)
2002
26
Detection of parathyroid hormone-related protein in cats with humoral hypercalcemia of malignancy. (12019470)
2002
27
The prevalence of familial hypocalciuric hypercalcemia. (11353947)
2001
28
Bone resorption associated with uncoupling of osteoclastic and osteoblastic activities in adult T cell leukemia with hypercalcemia: case report. (11529470)
2001
29
Conflicting actions of parathyroid hormone-related protein and serum calcium as regulators of 25-hydroxyvitamin D(3)-1 alpha-hydroxylase expression in a nude rat model of humoral hypercalcemia of malignancy. (11691644)
2001
30
Ameloblastic carcinoma ex ameloblastoma of the mandible with malignancy-associated hypercalcemia. (11113817)
2000
31
Hypercalcemia in children with rhabdomyosarcoma. (9703006)
1998
32
Parathyroid hormone-related protein and hypercalcemia. (9362423)
1997
33
Parathyroid glands and the multiple endocrine neoplasia syndromes and familial hypocalciuric hypercalcemia. (9088067)
1997
34
Nephrocalcinosis and nephrolithiasis due to subcutaneous fat necrosis with hypercalcemia in two full-term asphyxiated neonates: sonographic findings. (7596662)
1995
35
Parathyroid hormone-related protein expression in human gastric adenocarcinomas not associated with hypercalcemia. (7572910)
1995
36
Boucher-Neuhauser syndrome associated with hypocalciuric hypercalcemia. (7718973)
1995
37
Circulating forms of immunoreactive parathyroid hormone-related protein for identifying patients with humoral hypercalcemia of malignancy: a comparative study with C-terminal(109-141)- and N-terminal(1-86)-region-specific PTHrP radioassay. (7702967)
1994
38
Hypercalcemia associated with all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. (8501972)
1993
39
Pathophysiology and management of severe hypercalcemia. (8325291)
1993
40
Medical treatment of malignant hypercalcemia]. (8259844)
1993
41
The development of hypercalcemia in a patient with an ovarian tumor producing parathyroid hormone-related protein. (1451066)
1992
42
Paraneoplastic hypercalcemia associated with adenosquamous carcinoma of the endometrium. (1989923)
1991
43
A randomized double-blind study of gallium nitrate compared with etidronate for acute control of cancer-related hypercalcemia. (1906532)
1991
44
Incidence and pathophysiology of hypercalcemia. (2105829)
1990
45
Parathyroid hormone-related protein and transforming growth factor activities in an extract from a breast cancer associated with humoral hypercalcemia of malignancy. (2558242)
1989
46
Nephrogenous cyclic AMP, adenylate cyclase-stimulating activity, and the humoral hypercalcemia of malignancy. (3016837)
1986
47
Congenital mesoblastic nephroma of infancy associated with hypercalcemia. (3007779)
1986
48
Humoral hypercalcemia caused by a rat Leydig-cell tumor is associated with suppressed parathyroid hormone secretion and increased urinary cAMP excretion. (6307850)
1983
49
Band keratopathy in hypercalcemia of myeloma. (7074461)
1982
50
Cutaneous lymphosarcoma with IgG monoclonal gammopathy, serum hyperviscosity and hypercalcemia in a cat. (17422170)
1982

Genetic Variations for Hypercalcemia

Expression for genes affiliated with Hypercalcemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypercalcemia

Search GEO for disease gene expression data for Hypercalcemia.

Pathways for genes affiliated with Hypercalcemia

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Hypercalcemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CALCA, CASR, AVPR2, PTH1R, PTHLH, PTH
2
Hide members
10.5CALCA, CASR, PRKAR1A, FGF23, AVPR2, PTH1R
310.5ALPL, PTH, PTHLH, PTH1R
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5PTH, PTH1R, CYP27B1, CYP24A1, TNFSF11, TNFRSF11A
510.5NR1I3, CYP24A1, CYP27B1
6
Vitamin D2 (ergocalciferol) metabolism
Hide members
10.5CYP24A1, CYP27B1, PTH
7
Hide members
10.5PTH, PTHLH, PTH1R
8
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.5TNFSF11, PRKAR1A, PTH1R, PTHLH, PTH
910.5TNFSF11, FGF23, PTH1R, PTH
1010.5TNFSF11, TNFRSF11A

Compounds for genes affiliated with Hypercalcemia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Hypercalcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1vitamin d4511.0CALCA, CASR, TNFSF11, CYP24A1, PRKAR1A, NR1I3
225-hydroxyvitamin d4511.0CALCA, CASR, TNFSF11, CYP24A1, CYP27B1, FGF23
31,25 dihydroxy vitamin d34511.0CYP27B1, CYP24A1, NR1I3, TNFSF11, TNFRSF11A, CASR
4cyclic amp45 2412.0PRKAR1A, NR1I3, CALCA, CYP27B1, PTH1R, PTHLH
5calcium45 50 11 2414.0ALPL, SPG7, PTH, CASR, CALCA, TNFRSF11A
6phosphorus4511.0PTH, PTHLH, FGF23, CYP27B1, NR1I3, CASR
7calcitriol45 60 11 2414.0TNFRSF11A, CASR, CALCA, TNFSF11, CYP24A1, CYP27B1
8pamidronate45 50 1112.9PTHLH, PTH, CASR, TNFSF11, CALCA
9cinacalcet45 29 1112.9NR1I3, PRKAR1A, CXADR, CASR, CALCA
10hydroxyapatite4510.9PTHLH, ALPL, FGF23, CASR, TNFSF11, TNFRSF11A
11forskolin45 50 1112.9PRKAR1A, CALCA, PTH, PTH1R
12alfacalcidol45 60 1112.9CYP24A1, CALCA, NR1I3, CYP27B1
13adenylate4510.9PRKAR1A, PTH, CXADR, CALCA, PTHLH, PTH1R
14pge24510.9PTH1R
15dexamethasone45 50 29 1113.9TNFSF11, STC1, NR1I3, PTH1R, PTH, CYP24A1
16neomycin4510.9CASR, PTHLH, PRKAR1A, NR1I3, CXADR
17steroid4510.9CXADR, STC1, CYP27B1, CYP24A1, PRKAR1A, NR1I3
18eb 108945 6011.9CYP27B1, PTHLH, CYP24A1, NR1I3
19lysine4510.9CXADR, AVPR2, SPG7, CYP27B1, NR1I3, CASR
20l-amino acid4510.9CXADR, NR1I3, PRKAR1A, CASR
21potassium45 11 2412.9CASR, TNFSF11, STC1, AVPR2
22ribonucleic acid4510.9NR1I3, CASR, PTH1R, CXADR, PTHLH, PTH
23strontium ranelate4510.9TNFSF11, CASR, CALCA
24alendronate45 50 1112.9PTHLH, PTH, TNFSF11, CALCA
25denosumab45 1111.9TNFSF11, TNFRSF11A, CALCA
26arginine4510.9NR1I3, CASR, PRKAR1A, PTH, FGF23, CXADR
27creatinine4510.9PTH, PTHLH, FGF23, TNFSF11, CASR, SPG7
28nitric oxide45 11 2412.9PTH, CASR, CALCA, PTH1R, CXADR, TNFSF11
2924,25-dihydroxyvitamin d34510.8CYP24A1, CYP27B1, CALCA
30paricalcitol45 1111.8CYP24A1, CYP27B1, PTH
31teriparatide45 1111.8CALCA, PTH1R, TNFSF11
32tyrosine4510.8CASR, CYP27B1, TNFRSF11A, NR1I3, FGF23, CXADR
33gadolinium4510.8PRKAR1A, CASR, NR1I3
34calcium carbonate4510.8CALCA, PTHLH, PTH
35estradiol45 11 2412.8PTHLH, NR1I3, STC1
36tartrate4510.8PTHLH, TNFSF11, CALCA
37phenylalanine4510.8CASR, NR1I3, FGF23, CXADR, ALPL
38serine4510.8PTHLH, PTH1R, CXADR, FGF23, CASR, TNFRSF11A
39clodronate45 50 1112.7PTHLH, CALCA, TNFSF11
40sodium45 2411.7TNFSF11, NR1I3, AVPR2, CASR
41calcipotriol45 60 29 1113.7CYP27B1, CYP24A1, NR1I3
42glutamate4510.7NR1I3, PRKAR1A, CASR, SPG7, CALCA, AVPR2
43zoledronic acid4510.7PTHLH, TNFSF11, CALCA
44deoxypyridinoline4510.6PTH, TNFSF11, CALCA
45magnesium45 11 2412.6PRKAR1A, ALPL, PTH, PTHLH, NR1I3, CASR
46retinoic acid45 2411.6CYP24A1, CYP27B1, CXADR, ALPL, PTHLH, PTH1R
47testosterone45 60 11 2413.5PTHLH, CYP27B1, NR1I3, TNFSF11, CALCA, PTH
48Calcidiol11 2411.5CYP24A1, CYP27B1
49calcifediol6010.4NR1I3, CYP27B1
50ibmx45 29 6012.2PTH, PTHLH, PTH1R, CALCA

GO Terms for genes affiliated with Hypercalcemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypercalcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.5ALPL, PTH, PTHLH, CXADR, FGF23, STC1

Biological processes related to Hypercalcemia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:03328010.8ALPL, CYP27B1, CYP24A1, STC1
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.8CALCA, PTH1R, PTHLH, PTH
3vitamin D catabolic processGO:04236910.8CYP24A1, CYP27B1, FGF23
4ossificationGO:00150310.8STC1, TNFSF11, TNFRSF11A, CASR
5monocyte chemotaxisGO:00254810.8CALCA, TNFSF11, TNFRSF11A
6bone resorptionGO:04545310.8TNFSF11, PTH, PTH1R
7cell-cell signalingGO:00726710.8TNFRSF11A, STC1, PTH, PTHLH, CALCA
8positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFSF11, TNFRSF11A
9TNFSF11-mediated signaling pathwayGO:07184710.7TNFSF11, TNFRSF11A
10skeletal system developmentGO:00150110.7ALPL, PTH1R, PTHLH, PTH
11positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.7TNFSF11, TNFRSF11A
12positive regulation of cAMP biosynthetic processGO:03081910.7CALCA, PTHLH, PTH
13cAMP metabolic processGO:04605810.7PTH, PTHLH
14positive regulation of vitamin D 24-hydroxylase activityGO:01098010.6FGF23, CYP27B1
15cellular calcium ion homeostasisGO:00687410.6CASR, PTH, STC1
16vitamin D metabolic processGO:04235910.6CYP24A1, CYP27B1
17calcium ion homeostasisGO:05507410.5TNFSF11, CYP27B1
18mammary gland alveolus developmentGO:06074910.5TNFRSF11A, TNFSF11
19response to lipopolysaccharideGO:03249610.4ALPL, CYP27B1, TNFRSF11A
20decidualizationGO:04669710.2STC1, CYP27B1

Molecular functions related to Hypercalcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.5PTH, PTHLH
2hormone activityGO:00517910.2PTH, PTHLH, STC1, CALCA

Products for genes affiliated with Hypercalcemia

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Sources for Hypercalcemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet