MCID: HYP004
MIFTS: 65

Hypercalcemia malady

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Summaries for Hypercalcemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hypercalcaemia (British English) or hypercalcemia (American English) is an elevated calcium (Ca2+) level... more...

MalaCards: Hypercalcemia, also known as hypercalcinemia, is related to hyperparathyroidism and primary hyperparathyroidism. An important gene associated with Hypercalcemia is CASR (calcium-sensing receptor), and among its related pathways are Endocrine and other factor-regulated calcium reabsorption and superpathway of cholesterol biosynthesis. The drugs calcitonin and edetic acid, disodium salt and the compounds 22-oxacalcitriol and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related mouse phenotypes are other and craniofacial.

Aliases & Classifications for Hypercalcemia

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8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
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Aliases & Descriptions:

hypercalcemia 8 22 10 45 62
hypercalcinemia 8
hypercalcaemia 8


External Ids:

Disease Ontology8 DOID:12678
NCIt40 C3112
MeSH35 D006934
ICD9CM27 275.42

Related Diseases for Hypercalcemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypercalcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 365)
idRelated DiseaseScoreTop Affiliating Genes
1hyperparathyroidism30.9CYP27B1, PTHLH, CASR, ALPL, NR1I3, FGF23
2primary hyperparathyroidism30.7CYP27B1, FGF23, NR1I3, CASR, PTHLH, PTH1R
3nephrocalcinosis30.7NR1I3, CASR
4williams syndrome30.6CYP27B1
5parathyroid adenoma30.6PTHLH, CASR, ALPL
6breast cancer30.4PTHLH, PTH1R, CYP24A1, CYP27B1
7paraneoplastic syndromes30.4PTHLH, FGF23
8hyperphosphatemia30.4FGF23, ALPL, CASR
9hypoparathyroidism30.3PTH1R, PTHLH, CASR, NR1I3, FGF23
10hypervitaminosis d30.2FGF23, CYP27B1
11renal osteodystrophy30.0CASR, ALPL, FGF23
12calcinosis30.0CASR, ALPL, FGF23
13hypophosphatemia30.0FGF23, ALPL, PTHLH, CYP27B1
14graves' disease30.0FGF23, CASR, CYP27B1
15prostate cancer29.9ALPL, CASR, PTHLH, PTH1R, CYP24A1, CYP27B1
16rickets29.9CASR, CYP27B1
17nephrolithiasis29.9CASR, NR1I3, FGF23
18hyperthyroidism29.9ALPL, FGF23
19hyperparathyroidism, neonatal29.8NR1I3, CASR
20osteitis fibrosa29.8ALPL, CASR
21osteoporosis29.7FGF23, NR1I3, CYP27B1, CYP24A1, PTH1R, PTHLH
22pseudohypoparathyroidism29.7GNA11, PTH1R, PTHLH
23fibrous dysplasia29.7GNA11, ALPL, FGF23
24osteomalacia29.6PTH1R, CYP24A1, CYP27B1, PTHLH, CASR, ALPL
25primary hyperoxaluria29.5CYP27B1, CYP24A1, CASR, NR1I3, FGF23
26humoral hypercalcemia of malignancy10.8
27familial hypocalciuric hypercalcemia10.8
28leukemia10.6
29pancreatitis10.5
30familial hypocalciuric hypercalcemia type 310.5
31sarcoidosis10.5
32adenocarcinoma10.4
33adenoma10.4
34parathyroid carcinoma10.4
35t-cell leukemia10.4
36familial hypocalciuric hypercalcemia type 110.4
37myeloma10.3
38familial hypocalciuric hypercalcemia type 210.3
39adult t-cell leukemia10.3
40leydig cell tumor10.3
41lymphoblastic leukemia10.3
42thyroiditis10.3
43hypocalciuric hypercalcemia, type i10.3
44multiple myeloma10.3
45renal cell carcinoma10.3
46dysgerminoma10.3
47hypervitaminosis a10.2
48lung cancer10.2
49tuberculosis10.2
50lymphosarcoma10.2

Graphical network of the top 20 diseases related to Hypercalcemia:



Diseases related to hypercalcemia

Symptoms for Hypercalcemia

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Drugs & Therapeutics for Hypercalcemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Hypercalcemia

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22GTR
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Genetic tests related to Hypercalcemia:

id Genetic test Affiliating Genes
1 Hypercalcemia22

Anatomical Context for Hypercalcemia

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33MalaCards
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MalaCards organs/tissues related to Hypercalcemia:

33
Bone, Kidney, Lung, T cells, Breast, Thyroid, B cells, Ovary, Prostate, Liver, Colon, Pancreas, Myeloid, Pituitary, Bone marrow, Tongue, Endothelial, Skin, Testes, Thymus, Lymph node, Heart, Testis, Pancreatic islet

Animal Models for Hypercalcemia or affiliated genes

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37MGI
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Publications for Hypercalcemia

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52PubMed
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Articles related to Hypercalcemia:

(show top 50)    (show all 1151)
idTitleAuthorsYear
1
Differentiating familial hypocalciuric hypercalcemia from primary hyperparathyroidism. (23425644)
2013
2
Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia. (24377594)
2013
3
Sarcoidosis in a chronic dialysis patient diagnosed by sarcoidosis-related hypercalcemia with no common systemic clinical manifestations: a case report and review of the literature. (24292755)
2013
4
Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma. (22534085)
2013
5
An unusual case of malignancy-related hypercalcemia. (24353437)
2013
6
Hypercalcemia and osteolytic lesions as presenting symptoms of acute lymphoblastic leukemia in childhood. The use of zoledronic acid and review of the literature. (23934636)
2013
7
Hypercalcemia in children receiving pharmacologic doses of vitamin D. (22412034)
2012
8
Mirror, mirror on the wall: hypercalcemia as a consequence of modern cosmetic treatment with liquid silicone. (22293885)
2012
9
Primary hyperparathyroidism and familial hypocalciuric hypercalcemia: relationships and clinical implications. (22232026)
2012
10
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. (23087723)
2012
11
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. (22937283)
2011
12
Flare hypercalcemia after letrozole in a patient with liver metastasis from breast cancer: a case report. (21970715)
2011
13
Forearm bone mineral density in familial hypocalciuric hypercalcemia and primary hyperparathyroidism: a comparative study. (21785908)
2011
14
Hypercalcemia and soft tissue calcification owing to sarcoidosis: the sunlight-cola connection. (20200968)
2010
15
A case of ovarian cancer associated with hypercalcemia. (18845526)
2008
16
Active crohn disease and hypercalcemia treated with infliximab: case report and literature review. (18238746)
2008
17
Idiopathic infantile hypercalcemia and renal involvement. (17978858)
2008
18
Commentary on 'Pamidronate: treatment for severe hypercalcemia in neonatal subcutaneous fat necrosis' by Alos N. et al., Hormone Research 2006;65:289-294. (18772600)
2008
19
An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations. (17372216)
2007
20
Prevalence of hypercalcemia in hospitalised patients: effects of "correction" for serum albumin values. (16075918)
2005
21
Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia. (15715044)
2005
22
Hypercalcemia in prostate cancer with positive neuron-specific enolase stain. (15354984)
2004
23
An elderly case of non-Hodgkin's lymphoma (NHL) with hypercalcemia]. (12708052)
2003
24
Congenital sucrase-isomaltase deficiency presenting with failure to thrive, hypercalcemia, and nephrocalcinosis. (12014995)
2002
25
Hypercalcemia due to immobilization in critically ill children: calcitnonin treatment]. (11412402)
2001
26
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
27
Hypercalcemia induced with the plasma levels of parathyroid hormone-related peptide in multiple myeloma. (11030205)
2000
28
Hypercalcemia in neonatal distal renal tubular acidosis. (10775085)
2000
29
Serum levels of carboxyterminal propeptide of type I procollagen (PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP) and carboxyterminal parathyroid hormone-related protein (C-PTHrP) in hematological malignancies with bone lesions and hypercalcemia]. (9597894)
1998
30
Hypercalcemia due to endogenous overproduction of active vitamin D in identical twins with cat-scratch disease. (9480364)
1998
31
Significance of parathyroid hormone-related protein as a factor stimulating bone resorption and causing hypercalcemia in myeloma. (9766803)
1998
32
Role of Parathyroid Hormone Related Peptide (PTHrP) in Hypercalcemia of Malignancy and the Development of Osteolytic Metastases. (19078166)
1997
33
Hypercalcemia associated with all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. (8501972)
1993
34
Osseous and intestinal compartments in the humoral hypercalcemia of malignancy associated to Walker 256 tumor in rats. (8451038)
1993
35
Increased 1,25-(OH)2D2 concentration in a patient with malignancy-associated hypercalcemia receiving intravenous hyperalimentation inadvertently supplemented with vitamin D2. (8012094)
1993
36
Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamous carcinoma. (8428354)
1993
37
NMR solution structure of the [Ala26]parathyroid-hormone-related protein(1-34) expressed in humoral hypercalcemia of malignancy. (8425530)
1993
38
Plasma intact parathyroid hormone (PTH) and PTH-related peptide in familial benign hypercalcemia: greater responsiveness to endogenous PTH than in primary hyperparathyroidism. (1997510)
1991
39
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. (1999505)
1991
40
Intravenous pamidronic acid in hypercalcemia due to parathyroid carcinoma. (1820495)
1991
41
A case of pheochromocytoma producing parathyroid hormone-related protein and presenting with hypercalcemia. (2347892)
1990
42
Nephrocalcinosis, hypercalcemia, sarcoidosis or primary hyperparathyroidism? (3983783)
1985
43
Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy. (6546543)
1984
44
Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy. (6577602)
1983
45
Hypophosphatemia-induced hypercalcemia during acute renal failure. (6671351)
1983
46
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. (6298791)
1983
47
Familial hypocalciuric hypercalcemia: the relation to primary parathyroid hyperplasia. (7045673)
1982
48
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
49
Bone resorption and humoral hypercalcemia of malignancy: stimulation of bone resorption in vitro by tumor extracts is inhibited by prostaglandin synthesis inhibitors. (6793615)
1981
50
Hypercalcemia and head and neck cancer. Bony metastases from tongue cancer. (697640)
1978

Variations for Hypercalcemia

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Expression for genes affiliated with Hypercalcemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypercalcemia

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Pathways for genes affiliated with Hypercalcemia

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 53QIAGEN, 51PharmGKB
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Pathways related to Hypercalcemia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AP2S1, PTH1R
2
Show member pathways
Cholesterol biosynthesis38
lanosterol biosynthesis38
zymosterol biosynthesis38
mevalonate pathway I38
epoxysqualene biosynthesis38
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)38
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)38
trans, trans-farnesyl diphosphate biosynthesis38
cholesterol biosynthesis I38
cholesterol biosynthesis III (via desmosterol)38
geranylgeranyldiphosphate biosynthesis38
9.3CYP24A1, CYP27B1
3
Show member pathways
9.3CYP24A1, CYP27B1
49.3CYP24A1, CYP27B1
59.3PTHLH, PTH1R, GNA11
6
Show member pathways
9.3GNA11, PTH1R, PTHLH
79.2ALPL, PTHLH, PTH1R
89.1FGF23, PTH1R
98.9NR1I3, CYP24A1, CYP27B1
108.8CYP27B1, CYP24A1, PTH1R
11
Show member pathways
7.8GNA11, PTH1R, PTHLH, AP2S1, CASR, FGF23

Compounds for genes affiliated with Hypercalcemia

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Hypercalcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
122-oxacalcitriol4510.2PTHLH, CASR
2pamidronate45 51 1112.1PTHLH, CASR
3gadolinium4510.1CASR, NR1I3
4cinacalcet45 29 1112.0CASR, NR1I3
5l-tryptophan51 29 45 24 1114.0NR1I3, CASR
6l-amino acid4510.0NR1I3, CASR
7calcifediol619.8CYP27B1, NR1I3
8Propyl alcohol249.8ALPL, NR1I3
9Isopropyl alcohol249.8ALPL, NR1I3
10Ercalcitriol249.7CYP24A1, CYP27B1
11sevelamer459.7CASR, FGF23
12Calcidiol24 1110.7CYP27B1, CYP24A1
13neomycin459.7NR1I3, CASR, PTHLH
141-Hexanol249.7NR1I3, ALPL
15Ergocalciferol24 1110.7CYP24A1, CYP27B1
16Vitamin D3249.7CYP27B1, CYP24A1
17paricalcitol45 1110.7CYP27B1, CYP24A1
181-Pentanol249.7NR1I3, ALPL
1924,25-dihydroxyvitamin d3459.7CYP27B1, CYP24A1
20Isobutanol249.6NR1I3, ALPL
21inositol 1,4,5 trisphosphate459.5NR1I3, CASR, PTH1R
221-Butanol249.5NR1I3, ALPL
23ketoconazole45 29 24 1112.3CYP24A1, CYP27B1
24alfacalcidol45 61 1111.3CYP27B1, CYP24A1, NR1I3
25calcipotriol45 61 29 1112.3NR1I3, CYP24A1, CYP27B1
26magnesium45 24 1111.2PTHLH, CASR, ALPL, NR1I3
27ribonucleic acid459.2NR1I3, CASR, PTHLH, PTH1R
28clotrimazole29 45 24 1112.1NR1I3, CYP27B1
29lysine459.1NR1I3, CASR, PTHLH, CYP27B1
30alanine459.0PTH1R, PTHLH, CASR, NR1I3
31hydrogen45 2410.0CYP27B1, PTH1R, PTHLH, CASR
32hydroxyapatite459.0FGF23, ALPL, CASR, PTHLH
33eb 108945 619.9CYP27B1, CYP24A1, PTHLH, NR1I3
34dexamethasone45 51 29 1111.9NR1I3, PTHLH, PTH1R, CYP24A1
35phenylalanine458.9CASR, ALPL, NR1I3, FGF23
36arginine458.8PTHLH, CASR, NR1I3, FGF23
37forskolin45 51 1110.6CYP27B1, CYP24A1, PTH1R, PTHLH, CASR
38pge2458.6CYP27B1, CYP24A1, PTH1R, PTHLH, CASR
39steroid458.4CYP27B1, CYP24A1, PTH1R, PTHLH, NR1I3
40serine458.3PTH1R, PTHLH, CASR, NR1I3, FGF23
4125-hydroxyvitamin d458.3CYP27B1, CYP24A1, PTHLH, CASR, FGF23
42tyrosine458.1CYP27B1, PTHLH, CASR, NR1I3, FGF23
43cyclic amp45 249.1NR1I3, CASR, PTHLH, PTH1R, CYP24A1, CYP27B1
44estrogen458.1CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, NR1I3
45retinoic acid45 249.0CYP27B1, CYP24A1, PTH1R, PTHLH, ALPL, NR1I3
46phosphorus457.8CYP27B1, PTH1R, PTHLH, CASR, NR1I3, FGF23
471,25 dihydroxy vitamin d3457.3CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, NR1I3
48calcitriol45 61 24 1110.3CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, NR1I3
49vitamin d456.9FGF23, CYP27B1, NR1I3, ALPL, CASR, PTHLH
50calcium45 51 24 119.9CYP27B1, CYP24A1, PTH1R, PTHLH, CASR, ALPL

GO Terms for genes affiliated with Hypercalcemia

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16Gene Ontology
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Biological processes related to Hypercalcemia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endochondral ossificationGO:0019589.8ALPL, PTHLH
2osteoblast developmentGO:0020769.7PTH1R, PTHLH
3adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:0071889.6PTH1R, GNA11
4vitamin D metabolic processGO:0423599.5CYP24A1, CYP27B1
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.5PTH1R, PTHLH
6bone mineralizationGO:0302829.4PTH1R, CYP27B1
7steroid metabolic processGO:0082029.3CYP24A1, CYP27B1
8positive regulation of vitamin D 24-hydroxylase activityGO:0109809.2FGF23, CYP27B1
9response to vitamin DGO:0332809.2ALPL, CYP24A1, CYP27B1
10skeletal system developmentGO:0015019.1GNA11, PTH1R, PTHLH, ALPL
11vitamin D catabolic processGO:0423698.8FGF23, CYP24A1, CYP27B1
12negative regulation of cell proliferationGO:0082858.7PTHLH, PTH1R, CYP27B1

Products for genes affiliated with Hypercalcemia

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  • Antibodies
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Sources for Hypercalcemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet