MCID: HYP004
MIFTS: 69

Hypercalcemia malady

Summaries for Hypercalcemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypercalcaemia (British English) or hypercalcemia (American English) is an elevated calcium (Ca2+) level... more...

MalaCards: Hypercalcemia, also known as hypercalcinemia, is related to hyperparathyroidism and primary hyperparathyroidism. An important gene associated with Hypercalcemia is CASR (calcium-sensing receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs calcitonin and edetic acid, disodium salt and the compounds vitamin d and 25-hydroxyvitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related mouse phenotypes are growth/size and skeleton.

Aliases & Classifications for Hypercalcemia

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

hypercalcemia 8 22 10 44 60
hypercalcinemia 8
hypercalcaemia 8


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Disease Ontology8 DOID:12678
ICD9CM27 275.42
NCIt39 C3112
MeSH34 D006934

Related Diseases for Hypercalcemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypercalcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 372)
idRelated DiseaseScoreTop Affiliating Genes
1hyperparathyroidism31.1ALPL, PTH, PTHLH, CXADR, FGF23, CYP27B1
2primary hyperparathyroidism30.9PTH, PTHLH, PTH1R, CXADR, FGF23, CYP27B1
3parathyroid carcinoma30.9CASR, PTH
4leukemia30.9STC1, CYP24A1, CYP27B1, CXADR, ALPL
5pancreatitis30.7ALPL, CASR
6sarcoidosis30.6CYP27B1
7adenocarcinoma30.6CASR, TNFSF11, CYP27B1, CXADR, PTHLH
8adenoma30.5CALCA, CASR, PRKAR1A, NR1I3, CXADR, PTH
9nephrocalcinosis30.5NR1I3, CASR
10parathyroid adenoma30.5CALCA, CASR, PRKAR1A, CXADR, PTHLH, PTH
11breast cancer30.5PTHLH, PTH1R, CYP27B1, CYP24A1, STC1
12myeloma30.4TNFRSF11A, TNFSF11, PTHLH, ALPL
13hypoparathyroidism30.4PRKAR1A, CASR, CALCA, NR1I3, FGF23, CXADR
14thyroiditis30.4CALCA
15hyperphosphatemia30.3ALPL, PTH, FGF23, CASR
16osteosclerosis30.2TNFSF11, PTH, ALPL
17hypervitaminosis d30.2CYP27B1, FGF23
18bone carcinoma30.2PTHLH, TNFSF11, TNFRSF11A
19prostate cancer30.1CASR, TNFRSF11A, TNFSF11, CYP24A1, CYP27B1, CXADR
20hepatocellular carcinoma30.1TNFSF11, STC1, NR1I3, CYP27B1, CXADR, ALPL
21hypophosphatasia30.1ALPL
22osteoporosis30.1PTHLH, PTH1R, CXADR, FGF23, CYP27B1, CYP24A1
23hypophosphatemia30.1ALPL, PTH, PTHLH, FGF23, CYP27B1, CALCA
24renal osteodystrophy30.0CALCA, CASR, FGF23, PTH, ALPL
25calcinosis30.0CASR, FGF23, PTH, ALPL
26melanoma30.0TNFSF11, NR1I3, CYP24A1, CYP27B1, CXADR
27osteopetrosis30.0TNFSF11, TNFRSF11A
28rheumatoid arthritis30.0CYP27B1, TNFSF11, TNFRSF11A
29graves' disease30.0CASR, CYP27B1, FGF23
30osteomalacia29.8ALPL, PTH, PTHLH, PTH1R, FGF23, CYP27B1
31paget's disease of bone29.8CALCA, TNFRSF11A, ALPL
32nephrolithiasis29.8CASR, NR1I3, FGF23, PTH
33hyperthyroidism29.8ALPL, PTH, FGF23
34diabetes insipidus29.8AVPR2
35cushing's syndrome29.8AVPR2, PRKAR1A, CALCA
36rickets29.8PTH, CYP27B1, CASR
37hyperparathyroidism, neonatal29.6CASR, PRKAR1A, NR1I3, CXADR
38osteitis fibrosa29.6CASR, PTH, ALPL
39pseudohypoparathyroidism29.6CALCA, PTH1R, PTHLH, PTH
40fibrous dysplasia29.6FGF23, ALPL
41giant cell tumor29.6CALCA, TNFRSF11A, TNFSF11, FGF23
42thyroid cancer29.6PTH, PRKAR1A, CALCA
43wermer syndrome29.6PTH, PRKAR1A, CASR
44hyperostosis29.6FGF23
45colon cancer29.6CASR, CYP24A1, CYP27B1, CXADR
46thyroid medullary carcinoma29.6PRKAR1A, CASR, CALCA
47psoriasis29.6CYP24A1, CYP27B1
48primary hyperoxaluria29.6CALCA, PTH, ALPL
49pheochromocytoma29.6STC1, CALCA
50acromegaly29.6PRKAR1A

Graphical network of the top 20 diseases related to Hypercalcemia:



Diseases related to hypercalcemia

Clinical Features for Hypercalcemia

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Drugs & Therapeutics for Hypercalcemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hypercalcemia

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22GTR
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Genetic tests related to Hypercalcemia:

id Genetic test Affiliating Genes
1 Hypercalcemia22

Anatomical Context for Hypercalcemia

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32MalaCards
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MalaCards organs/tissues related to Hypercalcemia:

32
Bone, Kidney, Lung, T cells, Breast, Thyroid, B cells, Liver, Prostate, Colon, Ovary, Pancreas, Myeloid, Pituitary, Bone marrow, Endothelial, Tongue, Skin, Testis, Testes, Heart, Thymus, Lymph node, Pancreatic islet

Animal Models for Hypercalcemia or affiliated genes

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36MGI
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Publications for Hypercalcemia

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50PubMed
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Articles related to Hypercalcemia:

(show top 50)    (show all 1160)
idTitleAuthorsYear
1
Approach to diagnosis and treatment of hypercalcemia in a patient with malignancy. (24021907)
2014
2
Hypercalcemia and osteolytic lesions as presenting symptoms of acute lymphoblastic leukemia in childhood. The use of zoledronic acid and review of the literature. (23934636)
2013
3
An unusual case of hypercalcemia in a patient with renal insufficiency: Answer. (24048468)
2013
4
Hypercalcemia due to giant cell myocarditis: a case report. (24311400)
2013
5
Serum Calcitonin May Falsely Estimate Tumor Burden in Chronic Hypercalcemia: A Case of Prostatic and Multiple Bone Metastases from Medullary Thyroid Cancer. (23985043)
2013
6
Hypercalcemia: from a rainy city to a sunny desert. (23538278)
2013
7
Acute hypercalcemia following excessive calcium supplementation in a dehydrated patient with progressive multiple sclerosis: vitamin d supplementation is a red herring-reply. (23753930)
2012
8
Paraneoplastic hypercalcemia in clear cell ovarian adenocarcinoma. (23056149)
2012
9
An instructive case of hypercalcemia preceding relapse of AML following allogeneic BMT. (20921940)
2011
10
Cinacalcet hydrochloride in combination with alendronate normalizes hypercalcemia and improves bone mineral density in patients with primary hyperparathyroidism. (21445714)
2011
11
Severe hypercalcemia in a patient treated for hypoparathyroidism with calcitriol. (20679997)
2010
12
First report of ectopic ACTH syndrome and PTHrP-induced hypercalcemia due to a hepatoblastoma in a child. (20133447)
2010
13
Clinical challenges and images in GI. Anal tumor with refractory hypercalcemia. (20332041)
2010
14
The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. (19797241)
2009
15
Active crohn disease and hypercalcemia treated with infliximab: case report and literature review. (18238746)
2008
16
Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report. (18691418)
2008
17
Medical treatment of malignancy-associated hypercalcemia. (18288996)
2008
18
Hypercalcemia in malignancies of the female genital tract]. (18488865)
2008
19
Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesothelioma. (19095601)
2008
20
Use of bisphosphonates for hypercalcemia in a child with alveolar rhabdomyosarcoma. (18773683)
2008
21
Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. (17669716)
2007
22
Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. (16603723)
2006
23
Humoral hypercalcemia complicating adenocarcinoma of the sigmoid colon: report of a case. (16034553)
2005
24
Hypercalcemia and multiple osteolytic lesions in a child with disseminated paracoccidioidomycosis and pulmonary tuberculosis]. (16106322)
2005
25
Pamidronate and calcitonin as therapy of acute cancer-related hypercalcemia in children. (11225473)
2001
26
Familial hypocalciuric hypercalcemia and other disorders with resistance to extracellular calcium. (11033758)
2000
27
A case of adenocarcinoma complicated with massive leukocytosis and hypercalcemia]. (11019567)
2000
28
Localization of familial benign hypercalcemia, Oklahoma variant (FBHOk), to chromosome 19q13. (9915958)
1999
29
Hypercalcemia associated with parathyroid hormone-related protein produced by B-cell type primary malignant lymphoma of the kidney. (9671137)
1998
30
Parathyroid hormone-related protein in hypercalcemia associated with hematological malignancy. (9643563)
1998
31
Neonatal severe hyperparathyroidism, secondary hyperparathyroidism, and familial hypocalciuric hypercalcemia: multiple different phenotypes associated with an inactivating Alu insertion mutation of the calcium-sensing receptor gene. (9217223)
1997
32
Pulmonary blastoma with fatal hypercalcemia. (9154681)
1997
33
Clustered inactivating mutations and benign polymorphisms of the calcium receptor gene in familial benign hypocalciuric hypercalcemia suggest receptor functional domains. (8636323)
1996
34
Tumor-induced hypercalcemia in a patient with extensive soft tissue sarcoma: effects of bisphosphonate therapy and surgery. (8888806)
1996
35
Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia. (7726161)
1995
36
Simultaneous production of parathyroid hormone-related protein (PTHrP) and granulocyte colony-stimulating factor (G-CSF) in lung cancer patients with hypercalcemia and leukocytosis]. (7535368)
1995
37
Gonadal dysgerminoma-seminoma associated with severe hypercalcemia. (8382437)
1993
38
Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. (2019273)
1991
39
Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. (1955513)
1991
40
A case of pheochromocytoma producing parathyroid hormone-related protein and presenting with hypercalcemia. (2347892)
1990
41
The usefulness of biochemical markers of bone remodelling in the diagnosis and follow-up of Paget's disease of bone, primary hyperparathyroidism, tumoral hypercalcemia and postmenopausal osteoporosis. I. The markers of bone formation]. (2103291)
1990
42
Hypercalcemia and neoplasms: recent advances in pathogenesis]. (2291007)
1990
43
Parathyroid gland disease and hypercalcemia. (2223448)
1990
44
Synthetic peptides as tools for investigating the pathogenicity of disease: humoral hypercalcemia of malignancy. (2520752)
1989
45
Humoral hypercalcemia of malignancy in canine lymphosarcoma. (2828006)
1988
46
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. (3616618)
1987
47
The effect of low calcium diet, mithramycin, and dichlorodimethylene bisphosphonate on humoral hypercalcemia of malignancy in nude mice transplanted with the canine adenocarcinoma tumor line (CAC-8). (2971305)
1987
48
Neonatal primary hyperparathyroidism in familial hypocalciuric hypercalcemia. (7102625)
1982
49
Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. (6244324)
1980
50
Hypercalcemia and band keratopathy. (14387642)
1954

Genetic Variations for Hypercalcemia

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Expression for genes affiliated with Hypercalcemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypercalcemia

Search GEO for disease gene expression data for Hypercalcemia.

Pathways for genes affiliated with Hypercalcemia

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Hypercalcemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CALCA, PTH, PTHLH, PTH1R, AVPR2, CASR
2
Hide members
10.5PTHLH, PTH1R, AVPR2, PTH, FGF23, PRKAR1A
310.5PTH, PTHLH, PTH1R, ALPL
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5CALCA, TNFRSF11A, TNFSF11, CYP24A1, CYP27B1, PTH1R
510.5CYP24A1, CYP27B1, NR1I3
6
Vitamin D2 (ergocalciferol) metabolism
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10.5CYP24A1, PTH, CYP27B1
7
Hide members
10.5PTH1R, PTHLH, PTH
8
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.5PRKAR1A, PTH1R, PTHLH, TNFSF11, PTH
910.5FGF23, PTH1R, PTH, TNFSF11
1010.5TNFSF11, TNFRSF11A

Compounds for genes affiliated with Hypercalcemia

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Hypercalcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1vitamin d4411.0ALPL, CALCA, CASR, TNFSF11, PRKAR1A, NR1I3
225-hydroxyvitamin d4411.0CALCA, CASR, TNFSF11, CYP24A1, CYP27B1, FGF23
31,25 dihydroxy vitamin d34411.0TNFRSF11A, TNFSF11, NR1I3, CYP24A1, CYP27B1, FGF23
4calcitriol44 59 11 2414.0CALCA, CASR, TNFRSF11A, TNFSF11, NR1I3, CYP24A1
5phosphorus4411.0CALCA, CASR, TNFSF11, NR1I3, CYP27B1, FGF23
6cyclic amp44 2412.0CALCA, CASR, TNFSF11, PRKAR1A, NR1I3, CYP24A1
7calcium44 49 11 2414.0ALPL, CASR, TNFRSF11A, TNFSF11, STC1, PRKAR1A
8pamidronate44 49 1112.9CALCA, CASR, TNFSF11, PTHLH, PTH
9cinacalcet44 28 1112.9CALCA, CASR, PRKAR1A, NR1I3, CXADR
10hydroxyapatite4410.9CASR, TNFRSF11A, TNFSF11, FGF23, PTHLH, ALPL
11forskolin44 49 1112.9CALCA, PRKAR1A, PTH1R, PTH
12alfacalcidol44 59 1112.9CALCA, NR1I3, CYP24A1, CYP27B1
13adenylate4410.9CALCA, CASR, PRKAR1A, CXADR, AVPR2, PTH1R
14pge24410.9PTH1R
15dexamethasone44 49 28 1113.9TNFSF11, STC1, NR1I3, CYP24A1, CXADR, PTH1R
16neomycin4410.9CASR, PRKAR1A, NR1I3, CXADR, PTHLH
17steroid4410.9TNFSF11, STC1, PRKAR1A, NR1I3, CYP24A1, CYP27B1
18eb 108944 5911.9PTHLH, CYP27B1, CYP24A1, NR1I3
19lysine4410.9CASR, NR1I3, CYP27B1, CXADR, AVPR2, PTHLH
20l-amino acid4410.9CASR, PRKAR1A, NR1I3, CXADR
21potassium44 11 2412.9AVPR2, STC1, TNFSF11, CASR
22strontium ranelate4410.9CALCA, CASR, TNFSF11
23ribonucleic acid4410.9CASR, NR1I3, CXADR, PTH1R, PTHLH, PTH
24alendronate44 49 1112.9CALCA, TNFSF11, PTHLH, PTH
25arginine4410.9CASR, PRKAR1A, NR1I3, FGF23, CXADR, AVPR2
26creatinine4410.9CASR, TNFSF11, FGF23, PTHLH, PTH, SPG7
27denosumab44 1111.9CALCA, TNFRSF11A, TNFSF11
28nitric oxide44 11 2412.9CALCA, CASR, TNFRSF11A, TNFSF11, CXADR, PTH1R
29paricalcitol44 1111.8CYP24A1, CYP27B1, PTH
3024,25-dihydroxyvitamin d34410.8CALCA, CYP24A1, CYP27B1
31teriparatide44 1111.8CALCA, TNFSF11, PTH1R
32tyrosine4410.8CASR, TNFRSF11A, TNFSF11, NR1I3, CYP27B1, FGF23
33gadolinium4410.8CASR, PRKAR1A, NR1I3
34calcium carbonate4410.8CALCA, PTHLH, PTH
35estradiol44 11 2412.8PTHLH, NR1I3, STC1
36tartrate4410.8PTHLH, TNFSF11, CALCA
37phenylalanine4410.8CASR, NR1I3, FGF23, CXADR, ALPL
38serine4410.8CASR, TNFRSF11A, TNFSF11, STC1, NR1I3, FGF23
39clodronate44 49 1112.7PTHLH, TNFSF11, CALCA
40sodium44 2411.7CASR, TNFSF11, NR1I3, AVPR2
41calcipotriol44 59 28 1113.7CYP27B1, CYP24A1, NR1I3
42glutamate4410.7CALCA, CASR, PRKAR1A, NR1I3, CXADR, AVPR2
43zoledronic acid4410.7CALCA, TNFSF11, PTHLH
44deoxypyridinoline4410.6CALCA, TNFSF11, PTH
45magnesium44 11 2412.6CASR, PRKAR1A, NR1I3, PTHLH, PTH, ALPL
46retinoic acid44 2411.6NR1I3, CYP24A1, CYP27B1, CXADR, PTH1R, PTHLH
47testosterone44 59 11 2413.5PTH, PTHLH, CYP27B1, NR1I3, TNFSF11, CALCA
48calcifediol5910.5CYP27B1, NR1I3
49Calcidiol11 2411.4CYP27B1, CYP24A1
50ibmx44 28 5912.2CALCA, PTH1R, PTHLH, PTH

GO Terms for genes affiliated with Hypercalcemia

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16Gene Ontology
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Cellular components related to Hypercalcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.5ALPL, PTH, PTHLH, CXADR, FGF23, STC1

Biological processes related to Hypercalcemia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:03328010.8ALPL, CYP27B1, CYP24A1, STC1
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.8CALCA, PTH1R, PTHLH, PTH
3vitamin D catabolic processGO:04236910.8CYP24A1, CYP27B1, FGF23
4ossificationGO:00150310.8STC1, TNFSF11, TNFRSF11A, CASR
5monocyte chemotaxisGO:00254810.8CALCA, TNFSF11, TNFRSF11A
6bone resorptionGO:04545310.8TNFSF11, PTH, PTH1R
7cell-cell signalingGO:00726710.8TNFRSF11A, STC1, PTH, PTHLH, CALCA
8positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFSF11, TNFRSF11A
9TNFSF11-mediated signaling pathwayGO:07184710.7TNFSF11, TNFRSF11A
10skeletal system developmentGO:00150110.7ALPL, PTH1R, PTHLH, PTH
11positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.7TNFSF11, TNFRSF11A
12positive regulation of cAMP biosynthetic processGO:03081910.7CALCA, PTHLH, PTH
13cAMP metabolic processGO:04605810.7PTH, PTHLH
14positive regulation of vitamin D 24-hydroxylase activityGO:01098010.6FGF23, CYP27B1
15cellular calcium ion homeostasisGO:00687410.6CASR, PTH, STC1
16vitamin D metabolic processGO:04235910.6CYP24A1, CYP27B1
17calcium ion homeostasisGO:05507410.5TNFSF11, CYP27B1
18mammary gland alveolus developmentGO:06074910.5TNFRSF11A, TNFSF11
19response to lipopolysaccharideGO:03249610.4ALPL, CYP27B1, TNFRSF11A
20decidualizationGO:04669710.2STC1, CYP27B1

Molecular functions related to Hypercalcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.5PTH, PTHLH
2hormone activityGO:00517910.2PTH, PTHLH, STC1, CALCA

Products for genes affiliated with Hypercalcemia

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  • Antibodies
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Sources for Hypercalcemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet