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Hypercalcemia malady
15 drugs, 104 genes, 18 tissues, 954 related diseases, 25 phenotypes, 413 articles, clinical trials.

Summaries for Hypercalcemia

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44Wikipedia, 22MalaCards
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Wikipedia: Hypercalcaemia (British English) or hypercalcemia (American English) is an elevated calcium level in the...44 more...

MalaCards: Hypercalcemia, also known as hypercalcemia (disorder), is related to hypocalciuric hypercalcemia and familial hypocalciuric hypercalcemia. An important gene associated with Hypercalcemia is CASR (calcium-sensing receptor), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs prednisone pwdr [va product] and etidronate and the compounds phosphorus and cyclic amp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, colon and kidney, and related mouse phenotypes are craniofacial and respiratory system.

Aliases & Descriptions for Hypercalcemia

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 19ICD9CM, 27NCIt, 24MeSH
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Aliases & Descriptions:

hypercalcemia 6 8 32 43
hypercalcemia (disorder) 6
hypercalcinemia 6
hypercalcaemia 6

External Ids:

ICD9CM19 275.42
NCIt27 C3112

Related Diseases for Hypercalcemia

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13GeneCards, 14GeneDecks
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Diseases related to hypercalcemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 951)
idRelated DiseaseScoreTop Affiliating Genes
1hypocalciuric hypercalcemia35.6CASR, CALCA, PTH, SPG7, NR1I3, PRKAR1A
2familial hypocalciuric hypercalcemia35.3CASR, SPG7, NR1I3, CXADR
3humoral hypercalcemia of malignancy35.0BGLAP, FGF23, CASR, TNF, TNFRSF11A, TNFSF11
4primary hyperparathyroidism32.0VDR, BGLAP, SCT, CHGA, CD36, CDC73
5squamous cell carcinoma31.0CCND1, PTHLH, EGF, EGFR, TGFA
6multiple myeloma30.7FGFR3, IL6, CCND1, TNFSF11
7t-cell leukemia30.5IRF4, IL1A, IL2, IL2RB, IL3, PTHLH
8williams syndrome30.5VDR, CALCR, CALCA, CYP27B1, PDLIM1, ELN
9hypoparathyroidism29.8VDR, BGLAP, FGF23, IGF1, ALPP, CARS
10hypocalcemia29.2VDR, BGLAP, CD36, FGF23, GRM1, IAPP
11breast cancer29.2BMP6, CCND1, SRC, EGF, EGFR, TGFA
12dysgerminoma28.9ALPL, ALPP, ALPPL2, PTHLH, CYP27B1, AFP
13paget's disease of bone28.8BGLAP, B2M, CALCA
14adenosquamous carcinoma28.6CHGA, PTHLH, EGFR, TGFA
15neuroendocrine tumor28.5SCT, CHGA, MEN1, CALCA, SRC, SYP
16hypercalciuria28.1KL, VDR, BGLAP, B2M, FGF23, METTL1
17parathyroid adenoma27.8VDR, BGLAP, CHGA, CDC73, MEN1, CCND1
18osteitis fibrosa27.7BGLAP, B2M, ALPL, ALPP, ALPPL2, CASR
19pancreatic cancer27.7SCT, CHGA, MEN1, CCND1, IAPP, PTHLH
20parathyroid disorders27.7CDC73, MEN1, CASR, PTH, PTHLH
21parathyroid carcinoma27.7CDC73, MEN1, CASR, PTH, CXADR
22familial isolated hyperparathyroidism27.6CDC73, MEN1, CASR, PTH, GAST
23hypophosphatasia27.6CCL27, ALPL, ALPP, ALPPL2, CALCA, SLPI
24neuroendocrine carcinoma27.5CHGA, MEN1, CALCA, SYP, GAST
25adult t-cell leukemia27.4BMP6, B2M, IRF4, IL2, IL2RB, IL6
26nephrocalcinosis27.3ALB, CASR, CYP24A1, NR1I3, SLC34A1, SLC12A1
27hypoadrenalism27.1CALCA, PTHLH, TG, POMC
28acute lymphocytic leukemia27.1FGF2, IL2, IL3, TNF, PTHLH, LTA
29liver cirrhosis27.1LIF, SCT, AVP, AVPR2, ALB, ALPP
30cystic teratoma27.0VIM, PTHLH, SYP, CSF1
31hodgkin's lymphoma26.8IRF4, FGFR3, IL2, IL2RB, IL3, IL6R
32arthritis26.6IL1A, IL1B, IL6, TNF, TNFSF11
33cushing's syndrome26.6BGLAP, CHGA, AVPR2, MEN1, IGF1, CALCA
34bone cancer26.5VDR, CD36, IL1B, ALPL, ALPP, ALPPL2
35pancreatic endocrine carcinoma26.5CALCA, PTHLH, EGFR, SYP
36plasmacytoma26.4LIF, B2M, IRF4, IL2, IL2RB, IL6
37non-hodgkin lymphoma26.4VDR, B2M, CD52, IRF4, IL2, IL2RB
38osteomalacia26.3KL, GC, NBL1, VDR, BGLAP, CD36
39teratoma26.3VIM, LIF, ALPL, ALPP, ALPPL2, PTHLH
40squamous cell carcinoma of the head and neck26.3FGF2, IL6R, CCND1, SRC, EGF, EGFR
41large cell carcinoma26.2CHGA, PTHLH, EGFR, SYP
42osteopetrosis26.1BGLAP, IGF1, IFNG, CALCA, TNF, TNFRSF11A
43lung carcinoma26.1CHGA, AVP, CCND1, AMACR, ALPP, TNFRSF11A
44paraneoplastic syndromes26.1FGF23, IL2, IL6, ALB, CALCA, PTHLH
45interstitial lung disease26.0BMP6, IL1A, CCL3, EGFR
46renal cell carcinoma26.0VIM, B2M, FGF2, IL2, IL2RB, IL6R
47hypophosphatemia25.9KL, VDR, BGLAP, B2M, FGF2, FGF23
48acute promyelocytic leukemia25.9VDR, IL1A, IL1B, IL3, IL6, CCL4
49tuberculosis25.9VDR, IL1B, IFNG, TNF
50craniopharyngioma25.8VIM, AVP, IL1A, IL6, IGF1, CALCA

Graphical network of the top 20 diseases related to hypercalcemia:



Graphical network of diseases related to hypercalcemia

Clinical Features for Hypercalcemia

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Drugs & Therapeutics for Hypercalcemia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Inferred drug relations via UMLS/NDF-RT:

43 28 calcitonin, calcitonin,salmon, edetate disodium, edta, edta tetrasodium, etidronate, etidronate disodium, gallium nitrate, pamidronate, pamidronate disodium, plicamycin, prednisone, prednisone pwdr [va product], zoledronic, zoledronic acid

Genetic Tests for Hypercalcemia

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Anatomical Context for Hypercalcemia

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22MalaCards
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MalaCards organs/tissues related to hypercalcemia:

22
Bone marrow, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Prostate, Myeloid, T cells, B lymphoblasts, B cells, Tongue, Pancreatic islet, Pituitary

Phenotypes for genes affiliated with Hypercalcemia

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25MGI
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MGI Mouse Phenotypes related to hypercalcemia:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1craniofacial phenotypeMP:000538210.4CSF1, PRKAR1A, TGIF1, PTH1R, PTH, ALPL
2respiratory system phenotypeMP:000538810.2PRKAR1A, ELN, SRF, PTH1R, TRPV4, CALCA
3limbs/digits/tail phenotypeMP:00053719.4PTHLH, SRC, LTA, EGFR, TGIF1, TCF3
4embryogenesis phenotypeMP:00053809.1CXADR, PRKAR1A, TCF3, EGFR, SRC, PTH1R
5renal/urinary system phenotypeMP:00053678.9CASR, TRPV4, PTHLH, CYP24A1, CYP27B1, EGFR
6endocrine/exocrine gland phenotypeMP:00053798.7PRKAR1A, AFP, CDC73, MEN1, IL2, IL2RB
7hematopoietic system phenotypeMP:00053978.1FGF23, SPINK1, TG, TCF3, PRKAR1A, CXADR
8digestive/alimentary phenotypeMP:00053818.0CASR, PTH1R, PTHLH, SPINK1, EGF, EGFR
9liver/biliary system phenotypeMP:00053707.9EGFR, NR1I3, AMACR, IFNG, GPRC6A, IL6
10adipose tissue phenotypeMP:00053757.8ALPL, TNF, PTHLH, EGFR, TKT, TGFA
11normal phenotypeMP:00028737.6SRF, TGIF1, TCF3, SYP, STC1, PRKAR1A
12reproductive system phenotypeMP:00053897.4SLC12A1, ADCY10, AFP, VDR, LIF, B2M
13skeleton phenotypeMP:00053907.2IL6, CCND1, GPRC6A, IGF1, IAPP, ALPL
14behavior/neurological phenotypeMP:00053866.8SRC, PTHLH, TNFRSF11A, TRPV4, CALCA, CASR
15nervous system phenotypeMP:00036316.7EGFR, LTA, SPG7, SRC, PTHLH, TG
16integument phenotypeMP:00107716.7CASR, CALCA, TNFRSF11A, TNFSF11, PTHLH, SRC
17muscle phenotypeMP:00053696.6CASR, TRPV4, TNF, SRF, EGFR, ELN
18vision/eye phenotypeMP:00053916.2PTHLH, SRC, LTA, EGF, EGFR, TKT
19immune system phenotypeMP:00053876.2CDC73, IRF4, FGF23, FGFR3, MEN1, IL2
20growth/size phenotypeMP:00053785.9EGF, EGFR, TKT, TG, TGFA, TCF3
21tumorigenesisMP:00020065.4IGF1, IFNG, TNF, SRC, EGFR, TCF3
22mortality/agingMP:00107685.4KL, VDR, AVP, AVPR2, ATRN, CD36
23cellular phenotypeMP:00053844.7SRC, CYP27B1, PTHLH, TNFSF11, TNFRSF11B, TNFRSF11A
24homeostasis/metabolism phenotypeMP:00053764.4TGIF1, HLF, GAST, AFP, TCF3, PRKAR1A
25cardiovascular system phenotypeMP:00053854.2KL, VIM, VDR, LIF, CHGA, B2M

Publications for genes affiliated with Hypercalcemia

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35PubMed
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Articles related to hypercalcemia:

(show top 50)    (show all 413)
idTitleAuthorsYearAffiliating Genes
1A Patient with Primary Hyperparathyroidism Associated with Familial Hypocalciuric Hypercalcemia Induced by a Novel Germline CaSR Gene Mutation. (19423460)Yabuta T.... Amino N.2009CASR
2Cancer-induced Hypercalcemia. (19443365)Lumachi F.... Basso U.2009TNFSF11, CALCA, PTHLH
3Paraneoplastic humorally mediated hypercalcemia induc ed by parathyroid hormone-related protein in gynecologic malignancies: a system atic review. (19745599)Savvari P.... Papadimitriou C.A.2009PTHLH
4Mixed hepato/cholangiocarcinoma with paraneoplastic hypercalcemia. (18392720)Maarouf A.... Partensky C.2008PTHLH
5Hypercalcemia during pregnancy, puerperium, and lactation: review and a case report of hypercalcemic crisis after delivery due to excessive production of PTH-related protein (PTHrP) without malignancy (humoral hypercalcemia of pregnancy). (18614854)Sato K.2008PTHLH
6Hypercalcemia of malignancy: a study of clinical features and relationships among circulating levels of calcium, parathyroid hormone and parathyroid hormone-related peptide. (17487119)Sriussadaporn S.... Vichayanrat A.2007PTHLH
7Differential diagnosis of hypercalcemia in renal mali gnancy. (17656242)Klatte T.... Pantuck A.J.2007PTHLH
8Familial hypocalciuric hypercalcemia in the donor and recipient of a living related donor kidney transplant. (17217434)Novak J.E.... Greenberg A.2007CASR
9Multiple myeloma/hypercalcemia. (17634143)Oyajobi B.O.2007TNFSF11, CCL3
10Hypocalciuric hypercalcemia presenting as neonatal rib fractures: a newly described mutation of the calcium-sensing receptor gene. (17110864)Nyweide K.... Van Eenwyk C.2006CASR
11Parathyroid-hormone-related-protein-associated hypercalcemia in a patient with CLL-type low-grade leukemic B-cell lymphoma. (17194651)SchAPttker B.... Seufert J.2006PTHLH
12A case of renal pelvic squamous cell carcinoma accompanied with humoral hypercalcemia of malignancy (HHM) (15912787)Furukawa M.... Nakashima M.2005PTHLH, BGLAP
13Identification of a novel calcium-sensing receptor gene mutation causing familial hypocalciuric hypercalcemia by single-strand conformation polymorphism analysis. (15662592)Felderbauer P.... Schmidt W.E.2005CASR
14Establishment of a transplantable rat pulmonary carcinoma-derived cell line (IP-B12) as a new model of humoral hypercalcemia of malignancy and bone metastasis. (12853701)Nakanishi M.... Yamate J.2003PTHLH
15Loss of heterozygosity in parathyroid glands of familial hypercalcemia with hypercalciuria and point mutation in calcium receptor. (12161540)Szabo E.... Rastad J.2002PRKAR1A
16Marked hypercalcemia in a patient with hypocalciuric hypercalcemia without a mutation in the calcium-sensing receptor gene. (12521205)Hanibuchi N.... Konishi I.2002CASR
17Pamidronate and calcitonin as therapy of acute cancer-related hypercalcemia in children. (11225473)Schmid I.... Haas R.J.2001CALCA
18Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. (11289133)Oyajobi B.O.... Mundy G.R.2001TNFRSF11A, PTHLH
19Hypercalcemia due to immobilization in critically ill children: calcitnonin treatment (11412402)UrA!n Moreno M.... LA^pez-Herce Cid J.2001CALCA
20A novel mutation in Ca2+-sensing receptor gene in familial hypocalciuric hypercalcemia. (11762699)Nakayama T.... Kokubun S.2001CASR
21Tumor-induced hypercalcemia. Review of bisphosphonate treatment (11508158)Lortholary A.2001PTHLH
22Parathyroid hormone-related protein, parathyroid hormone, and vitamin D in hypercalcemia of malignancy. (10660809)MotellA^n J.L.... Esbrit P.2000PTH, PTHLH
23Parathyroid hormone-related protein in metastatic breast cancer induced hypercalcemia: a case report. (10690395)Graffeo R.... Goldhirsch A.2000PTHLH
24Molecular mechanism of action of parathyroid hormone related peptide in hypercalcemia of malignancy: therapeutic strategies (review). (10601566)Rabbani S.A.2000PTHLH
25Hypercalcemia in a woman with hypoparathyroidism associated with increased parathyroid hormone-related protein during lactation. (15251676)Shomali M.E.... Ross D.S.1999PTHLH
26Approach to examining hypercalcemia in the clinical laboratory (10639824)Shirata T.... Tominaga M.1999ALB
27Undifferentiated pancreatic cancer associated with humoral hypercalcemia of malignancy. (9793031)Kakizaki S.... Mori M.1998PTHLH
28Parathyroid hormone-related protein in hypercalcemia associated with hematological malignancy. (9643563)Firkin F.... Grill V.1998PTHLH
29Hypercalcemia in children with rhabdomyosarcoma. (9703006)Kawasaki H.... Ohira M.1998PTHLH
30Utility of measuring serum parathyroid hormone-related protein concentration in leukemic patients with hypercalcemia for assessing disease status. (9758444)Oda N.... Nagasaka A.1998PTHLH
31The role of interleukin-6 in the induction of hypercalcemia in renal cell carcinoma transplanted into nude mice. (9112382)Weissglas M.G.... Kurth K.H.1997IL6, PTHLH
32Hypercalcemia as the first manifestation of bone mar row T-cell lymphoma (9221199)Marecek Z.... Friedmann B.1997CALCA
33In vivo and in vitro characterization of neonatal hyperparathyroidism resulting from a de novo, heterozygous mutation in the Ca2+-sensing receptor gene: normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial benign hypocalciuric hypercalcemia. (9011580)Bai M.... Steinmann B.1997NR1I3
34Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo. (9242449)Uy H.L.... Guise T.A.1997PTHLH
35Acute management of cancer-related hypercalcemia. (8740333)Chisholm M.A.... Taylor A.T.1996CALCA
36Hypercalcemia in multiple myeloma (7699910)Takahashi T.1995IL1B, LTA
37Hypercalcemia of malignancy in the palliative care patient: a treatment strategy. (7543127)Kovacs C.S.... Bruera E.1995CALCA
38Humoral hypercalcemia of malignancy: some enigmas on the clinical features. (7768974)Ikeda K.... Ogata E.1995PTHLH
39Dysgerminoma of the ovary with hypercalcemia associated with elevated parathyroid hormone-related protein. (7596049)Inoue H.... Nagata I.1995PTHLH
40Insertion of an Alu sequence in the Ca(2+)-sensing receptor gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. (7717399)Janicic N.... Hendy G.N.1995CASR, CXADR
41A combination of calcitonin and bisphosphonate for the emergency treatment of severe tumor-induced hypercalcemia. (8453509)Luce K.... Morton A.R.1993CALCA
42A case of esophageal carcinoma with hypercalcemia caused by PTH-rP--the effect of therapy on the bone and calcium metabolism (1291340)Nakayama Y.... Morii H.1992PTHLH
43Urinary excretion of parathyroid hormone-related protein as a predictor of hypercalcemia in patients with adult T-cell leukemia. (1469794)Imamura H.... Sato K.1992PTHLH
44Expression of human transforming growth factor alpha by Chinese hamster ovarian tumors in nude mice causes hypercalcemia and increas ed osteoclastic bone resorption. (1642153)Yates A.J.... Mundy G.R.1992TGFA
45PTH-related protein (PTHrP) in serum of patients with tumor hypercalcemia (2056982)Scharla S.H.... Ziegler R.1991PTHLH
46Postpartum hypercalcemia in a patient with medullary sponge kidneys. (2024662)Siskind M.S.... Popovtzer M.M.1991PTHLH
47Effects of glucocorticoids and calcitonin on parathyroid hormone-related protein (PTHrP) gene expression and PTHrP release in human cancer cells causing humoral hypercalcemia. (1938595)Kasono K.... Demura H.1991CALCA, PTHLH
48Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. (1955513)Grill V.... Martin T.J.1991PTHLH
49Incidence and pathophysiology of hypercalcemia. (2105829)Mundy G.R.1990TNF, IL1A, PTHLH
50Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. (2320080)Burtis W.J.... Stewart A.F.1990PTHLH

Expression for genes affiliated with Hypercalcemia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Hypercalcemia

Pathways for genes affiliated with Hypercalcemia

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41Thomson Reuters, 10EMD Millipore, 36QIAGEN, 37R&D Systems, 20KEGG
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Pathways related to hypercalcemia according to GeneDecks:

(show top 50)    (show all 106)
idPathwayScoreTop Affiliating Genes
1Development_Hedgehog and PTH signaling pathways in bone and cartilage development4110.1TNFSF11, VDR, BGLAP, CCND1, PTH, PTH1R
2Development Hedgehog and PTH signaling pathways in bone and cartilage development1010.1TNFSF11, PTH1R, PTH, PRKAR1A, PTHLH, VDR
3IL-6 Pathway369.8CCL3, IL6R, IL3, BMP6, CCL4, CCL27
4IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types379.7CCL4, IL2RB, IL2, CCL3
5RAR-Gamma-RXR-Alpha Degradation369.6CSF3, CCL4, LTA, CCL3, CCL27, IL3
614-3-3 Induced Intracellular Signaling369.4FGFR3, FGF23, FGF2, SRC, TNF, IGF1
7NFAT Signaling and Lymphocyte Interactions369.3IL3, CCL4, BMP6, IL1A, IL2, CCL27
8Regulation of eIF4 and p70S6K369.2IL2, IL1A, IL3, IL6, CCL4, CCL27
9PGC1Alpha Pathway369.0CCL3, IL1B, BMP6, IL1A, IL2, IL2RB
10ERK5 Signaling368.9BMP6, FGF23, IL6, FGFR3, IL2, IL3
11CREB Pathway368.9PRKAR1A, IGF1, IL3, IL2, GRM1, FGFR3
12Hematopoietic cell lineage208.9IL1A, IL1B, CD36, IL6, TNF, CSF1
13Akt Signaling368.7LTA, TNFSF11, TNFRSF11A, TNF, CCL3, CCND1
14Rheumatoid arthritis208.7IL1B, IL1A, TNF, IL6, CCL3, IFNG
15MIF Regulation of Innate Immune Cells368.6CSF3, CSF1, LTA, TNFSF11, TNF, CCL3
16PEDF Induced Signaling368.6IL1A, LIF, BMP6, IL1B, CSF3, CSF1
17MIF Mediated Glucocorticoid Regulation368.6CCL27, CCL3, TNF, TNFSF11, LTA, CSF1
18all-trans-Retinoic Acid Signaling in Brain368.6CSF3, CSF1, LTA, IL2, TNF, CCL3
19Cytokine Network368.6LTA, IFNG, TNF, IL2, IL1A, IL1B
20Transcription_Role of VDR in regulation of genes involved in osteoporosis418.6VDR, BGLAP, IL1A, IL1B, IL6, IGF1
21Transcription Role of VDR in regulation of genes involved in osteoporosis108.6CYP27B1, CYP24A1, PTH1R, VDR, BGLAP, IL1A
22STAT3 Pathway368.3CSF1, LTA, SRC, TNFSF11, TNFRSF11A, TNF
23JNK Pathway368.3CCL4, EGF, IL2RB, IL2, FGFR3, FGF2
24PPAR Pathway368.3IL2, IL6, IGF1, IL3, FGF23, FGF2
25SOCS Pathway368.3IL3, IL2, IL1B, FGF23, IL6, IL1A
26Endothelin-1 Signaling Pathway368.1CCL3, TNFSF11, CCL27, IL1A, BMP6, IL6
27ILK Signaling368.1TGFA, TCF3, VIM, FGFR3, FGF2, IL3
28ERK Signaling367.8TGFA, PRKAR1A, CSF3, EGFR, EGF, IL2
29Apoptotic Pathways in Synovial Fibroblasts367.7EGFR, TNF, LTA, EGF, TGFA, IGF1
30p53 Mediated Apoptosis367.6IL3, IL6, IGF1, EGF, IL2, TGFA
31Molecular Mechanisms of Cancer367.6IL3, IL2, FGF23, FGF2, LIF, IL6
32Cellular Apoptosis Pathway367.6EGFR, EGF, BMP6, FGFR3, FGF2, TGFA
33GPCR Pathway367.6IL3, IGF1, IL6, IL2, FGFR3, FGF23
34Rho Family GTPases367.6CSF3, VIM, BMP6, CSF1, TGFA, ELN
35Nuclear Receptor Activation by Vitamin-A367.5IL3, IL6, IL2, IGF1, EGFR, TGFA
36DHA Signaling367.3BMP6, FGF2, FGF23, FGFR3, IL1B, TGFA
37Tec Kinases Signaling367.3IL6R, CCL4, IL2, IL2RB, IL3, TGFA
38NF-KappaB (p50-p65) Pathway367.3FGF23, EGF, BMP6, IL3, PRKAR1A, FGFR3
39NF-KappaB Family Pathway367.3TGFA, TNF, IGF1, IL2, IL1B, IL1A
40Mitochondrial Apoptosis367.1EGF, BMP6, FGF2, EGFR, TGFA, IL6
41PAK Pathway367.1FGF2, LIF, BMP6, FGF23, FGFR3, IL1A
42Estrogen Pathway367.0FGF23, EGF, SRC, IGF1, EGFR, TGFA
43MAPK Signaling367.0BMP6, FGF23, SRC, IGF1, TNF, LTA
44Pancreatic Adenocarcinoma366.9IL3, TGFA, FGF2, FGF23, BMP6, FGFR3
45TGF-Beta Pathway366.9IL2RB, FGF2, FGF23, FGFR3, IL1A, IL1B
46Cytokine-cytokine receptor interaction206.9TNFRSF11B, TNFSF11, TNFRSF11A, TNF, LIF, IL1A
47MAPK Family Pathway366.8FGF2, BMP6, TGFA, FGF23, FGFR3, IL1A
48Antioxidant Action of Vitamin-C366.5FGFR3, FGF23, FGF2, LIF, BMP6, IL1A
49p38 Signaling366.4CSF3, CSF1, TGFA, EGFR, EGF, LTA
50JAK-STAT Pathway366.0CCL3, IGF1, IFNG, EGF, TGFA, IL6R

Compounds for genes affiliated with Hypercalcemia

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32Novoseek , 18HMDB, 9DrugBank, 42Tocris Bioscience, 34PharmGKB
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Compounds related to hypercalcemia according to GeneDecks:

(show top 50)    (show all 401)
idCompoundScoreTop Affiliating Genes
1phosphorus32 10.4VDR, B2M, FGF23, ALPP, CASR, CALCA
2cyclic amp32 18 10.9LIF, SCT, CHGA, AVPR2, IL2RB, CCL4
3hydroxyapatite32 9.8VIM, BGLAP, CD36, MGP, FGF23, CCL27
4neomycin32 9.7VIM, IL1A, IL3, ALPP, CASR, PTHLH
5tartrate32 9.5VIM, BGLAP, CD36, ALPP, CALCR, CALCA
6zoledronic acid32 9.5BGLAP, CD36, IL2, ALPP, CALCA, TNFRSF11B
7ivig32 9.5IL3, CCL4, CRP, LTA, ELN, TG
8pmma32 9.5BMP6, B2M, CCL3, ALPP, CALCA, TNFRSF11B
9pamidronate32 9 9 11.3BGLAP, B2M, CD36, IL6, ALPP, CASR
10prostaglandin32 9.2VIM, LIF, SCT, IL1A, IL1B, IL6
11ascorbic acid32 18 10.1VDR, LIF, BGLAP, CD36, IL1A, IL3
12deoxypyridinoline32 9.0VDR, BGLAP, CD36, IL6R, CCL27, IGF1
13pge232 8.8LIF, SCT, FGF2, IL1A, CCL4, CCL27
14estradiol32 9 18 9 11.8GC, VIM, LIF, IL6R, CCND1, IAPP
15progesterone32 42 9 18 9 12.8LIF, CHGA, CCL4, CCND1, PTHLH, SRF
16aspartate32 8.7GC, VIM, VDR, BMP6, SCT, B2M
17heparin32 9 18 9 11.6VIM, LIF, BGLAP, CD36, FGF23, IL3
18ribonucleic acid32 8.6BMP6, LIF, CHGA, IL1A, IL1B, IL2RB
19agar32 8.3VIM, FGF2, CCND1, SRC, EGF, ELN
20forskolin32 42 9 9 11.3VIM, BMP6, LIF, SCT, CHGA, GRM1
21norepinephrine32 9 18 9 11.1BMP6, LIF, SCT, CHGA, AVP, IL1A
22cysteine32 8.1VDR, LIF, BGLAP, SCT, AVP, FGFR3
23okt332 8.0BMP6, IL2, IL2RB, IL6, IFNG, TNF
24rapamycin32 42 9.0VIM, IL2, IL2RB, IFNG, SRC, EGF
25steroid32 8.0GC, LIF, CHGA, B2M, AVP, IL2RB
26calcitriol32 42 9 18 9 11.9GC, VDR, BMP6, LIF, BGLAP, B2M
27adenylate32 7.9GC, VIM, VDR, SCT, CHGA, AVPR2
28nitric oxide32 9 18 9 10.8BMP6, LIF, CHGA, AVP, GRM1, IL1A
29lactate32 7.7VIM, BMP6, LIF, CHGA, B2M, IL2RB
30vitamin d32 7.7GC, VIM, VDR, BMP6, BGLAP, CHGA
31tgf beta132 7.5VIM, BMP6, LIF, CD36, FGF2, IL1B
32creatinine32 7.3GC, VDR, BMP6, CHGA, B2M, FGF23
33rantes32 7.3BMP6, LIF, SCT, IL1A, IL1B, IL2
34thalidomide32 42 9 9 10.1B2M, CD36, FGF2, FGFR3, IL1B, IL2
35testosterone32 9 18 9 10.1GC, VIM, VDR, LIF, BGLAP, SCT
36histamine32 18 8.1VIM, BMP6, BGLAP, SCT, CHGA, IL1B
37tamoxifen32 34 9 9 10.0VIM, VDR, BMP6, BGLAP, CHGA, IL2
38indomethacin32 9 9 9.0VIM, BMP6, SCT, B2M, IL1A, IL1B
39paraffin32 6.9VIM, LIF, BGLAP, CHGA, B2M, CD36
40cisplatin32 34 9 9 9.9BMP6, LIF, BGLAP, CHGA, B2M, IL2
41pd 98,05932 6.9BMP6, LIF, SCT, FGF2, IL1B, IL3
42cyclosporin a32 42 7.8VDR, BMP6, LIF, BGLAP, SCT, B2M
43actinomycin d32 6.7VIM, VDR, LIF, FGF2, IL1A, IL1B
44vegf32 6.5KL, LIF, BGLAP, CHGA, CD36, FGF2
45hydrocortisone32 9 9 7.4VIM, BMP6, LIF, BGLAP, CD36, FGF2
46tyrosine32 4.5KL, BMP6, LIF, SCT, CHGA, AVP
47serine32 4.5GC, VIM, VDR, BMP6, LIF, BGLAP
48genistein32 9 18 9 7.4VIM, VDR, LIF, B2M, CD36, FGF2
49dexamethasone32 42 34 9 9 8.1VIM, VDR, BMP6, LIF, BGLAP, CHGA
50cycloheximide32 3.2VIM, VDR, BMP6, LIF, CHGA, B2M

GO Terms for genes affiliated with Hypercalcemia

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12Gene Ontology
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Cellular components related to hypercalcemia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.6CXADR, PRKAR1A, OXA1L, SYP, TCF3, ALB
2integral to plasma membraneGO:0058878.9TRPV5, TNF, TNFSF11, PTH1R, CXADR, SLC34A1
3plasma membraneGO:0058867.1TGFA, EGFR, EGF, SRC, PTH1R, TNF
4extracellular regionGO:0055765.0GAST, IL6R, IL6, IL3, IL2, IL1B
5extracellular spaceGO:0056154.1AFP, POMC, CSF3, KL, CCL4, IL6R

Biological processes related to hypercalcemia according to GeneDecks:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1vitamin D catabolic processGO:04236910.8CYP27B1, CYP24A1, FGF23
2positive regulation of vitamin D 24-hydroxylase activityGO:01098010.8CYP27B1, FGF23, VDR
3osteoblast developmentGO:00207610.7PTHLH, PTH1R, MEN1, BGLAP
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.7PTHLH, PTH1R, PTH, CALCA, CALCR
5positive regulation of cAMP biosynthetic processGO:03081910.7PTHLH, PTH, CALCA, CALCR, AVP
6bone resorptionGO:04545310.7TNFSF11, PTH, PTH1R, SRC
7decidualizationGO:04669710.7STC1, CYP27B1, LIF, VDR
8osteoclast differentiationGO:03031610.7TNF, TNFRSF11A, TNFSF11, CSF1
9cellular calcium ion homeostasisGO:00687410.6STC1, PTH, TRPV4, CASR, CCL3, VDR
10monocyte chemotaxisGO:00254810.5TNFSF11, TNFRSF11A, CALCA, CCL3, IL6R, IL6
11response to vitamin DGO:03328010.5STC1, CYP27B1, CYP24A1, ALPL, IL1B, BGLAP
12negative regulation of bone resorptionGO:04577910.4TNFRSF11B, CALCA, IAPP
13positive regulation of macrophage differentiationGO:04565110.4CSF1, CALCA, LIF
14ossificationGO:00150310.3CSF1, STC1, EGFR, TNFSF11, TNFRSF11A, CASR
15defense response to Gram-positive bacteriumGO:05083010.2LTA, TNF, IL6R, IL6, CD36
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.1IL6R, IL6, FGFR3, LIF
17embryo implantationGO:00756610.0LIF, IL1B, CALCA, STC1
18positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.0TCF3, SRF, TNFSF11, TNFRSF11A, TNF, IL6
19positive regulation of cell divisionGO:0517819.9TGFA, IL1B, IL1A, MEN1, FGF2
20response to glucocorticoid stimulusGO:0513849.9SI, TNF, CALCR, ALPL, IL6, IL1B
21agingGO:0075689.9SI, PTH1R, CALCA, IL1B, VDR, KL
22positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.9TNFSF11, TNFRSF11A, TNF, TRIM13, IL1B, IL1A
23negative regulation of lipid storageGO:0108889.9CRP, TNF, IL6
24mammary gland alveolus developmentGO:0607499.9TGFA, EGF, TNFSF11, TNFRSF11A, CCND1
25positive regulation of osteoclast differentiationGO:0456729.9CSF1, TNFSF11, TNF, IFNG
26skeletal system developmentGO:0015019.9PTHLH, PTH1R, PTH, TNFRSF11B, ALPL, IGF1
27positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TNF, CCL3, IL1B, IL1A, FGFR3, FGF23
28positive regulation of interleukin-6 productionGO:0327559.8TNF, IL6R, IL6, IL1B, IL1A, CD36
29elevation of cytosolic calcium ion concentrationGO:0072049.7PTH1R, TRPV4, CALCA, CALCR, IL2, IL1B
30positive regulation of cerebellar granule cell precursor proliferationGO:0219409.7EGF, IGF1, FGF2
31negative regulation of growth of symbiont in hostGO:0441309.6LTA, TNF, IFNG, CD36
32MAPK cascadeGO:0001659.6TGFA, EGFR, TNF, CCL3, IL1B, MEN1
33positive regulation of NF-kappaB transcription factor activityGO:0510929.6TNFSF11, TNFRSF11A, TNF, IL6R, IL6, IL1B
34positive regulation of calcidiol 1-monooxygenase activityGO:0605599.6TNF, IFNG, IL1B
35positive regulation of MAPK cascadeGO:0434109.5IGF1, IL6R, IL6, FGFR3, CD36, LIF
36positive regulation of mitosisGO:0458409.5TGFA, EGF, TNF, IGF1, IL1B, IL1A
37positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IGF1, IL6R, IL6, IL3, CD36, LIF
38positive regulation of osteoblast differentiationGO:0456699.5IGF1, IL6R, IL6, MEN1, FGF2, BMP6
39positive regulation of protein kinase B signaling cascadeGO:0518979.5EGFR, TNFSF11, TNF, IGF1, CCL3
40positive regulation of neuron differentiationGO:0456669.3TCF3, TGIF1, IFNG, BMP6, NBL1
41immune responseGO:0069559.3CSF3, TNFSF11, IGHG1, CCL27, CCL4, IL3
42cell-cell signalingGO:0072679.2TNFRSF11A, PTH, PTHLH, LTA, STC1, POMC
43response to hypoxiaGO:0016669.1LTA, PDLIM1, CRP, SRF, TNF, IL1B
44response to drugGO:0424939.0TGIF1, TGFA, LTA, TNFRSF11B, TNF, IFNG
45negative regulation of cell proliferationGO:0082859.0TNF, PTH1R, PTHLH, CYP27B1, SRF, TGIF1
46inflammatory responseGO:0069549.0CSF1, CRP, TNF, CALCA, CCL3, CCL4
47cytokine-mediated signaling pathwayGO:0192218.7IL6R, IFNG, TNFSF11, CSF3, IL6, IL2RB
48positive regulation of cell proliferationGO:0082847.6LIF, CSF3, CSF1, EGFR, EGF, PTHLH
49signal transductionGO:0071657.4SRC, NR1I3, LTA, EGF, EGFR, TG
50positive regulation of transcription from RNA polymerase II promoterGO:0459447.1IGF1, IFNG, TNF, TNFSF11, PTH, SRF

Molecular functions related to hypercalcemia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vitamin D bindingGO:00549910.2VDR, GC, KL
2alkaline phosphatase activityGO:00403510.0ALPPL2, ALPP, ALPL
3receptor bindingGO:0051029.9CXADR, LTA, SRC, CALCA, IAPP, AMACR
4hormone activityGO:0051799.2GAST, POMC, STC1, TG, PTHLH, PTH
5growth factor activityGO:0080837.4IGF1, EGF, TGFA, CSF1, CSF3, IL6
6cytokine activityGO:0051257.3BMP6, CSF3, CSF1, LTA, TNFSF11, TNFRSF11B

Sources for Hypercalcemia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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