MCID: HYP004
MIFTS: 69

Hypercalcemia malady

Summaries for Hypercalcemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypercalcaemia (British English) or hypercalcemia (American English) is an elevated calcium (Ca2+) level... more...

MalaCards: Hypercalcemia, also known as hypercalcinemia, is related to hyperparathyroidism and primary hyperparathyroidism. An important gene associated with Hypercalcemia is CASR (calcium-sensing receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs calcitonin and edetic acid, disodium salt and the compounds vitamin d and 25-hydroxyvitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related mouse phenotypes are growth/size and skeleton.

Aliases & Classifications for Hypercalcemia

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

hypercalcemia 8 22 10 44 60
hypercalcinemia 8
hypercalcaemia 8


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Disease Ontology8 DOID:12678
ICD9CM27 275.42
NCIt39 C3112
MeSH34 D006934

Related Diseases for Hypercalcemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypercalcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 372)
idRelated DiseaseScoreTop Affiliating Genes
1hyperparathyroidism31.1ALPL, PTH, PTHLH, CXADR, FGF23, CYP27B1
2primary hyperparathyroidism30.9PTH, PTHLH, PTH1R, CXADR, FGF23, CYP27B1
3parathyroid carcinoma30.9CASR, PTH
4leukemia30.9STC1, CYP24A1, CYP27B1, CXADR, ALPL
5pancreatitis30.7ALPL, CASR
6sarcoidosis30.6CYP27B1
7adenocarcinoma30.6CASR, TNFSF11, CYP27B1, CXADR, PTHLH
8adenoma30.5CALCA, CASR, PRKAR1A, NR1I3, CXADR, PTH
9nephrocalcinosis30.5NR1I3, CASR
10parathyroid adenoma30.5CALCA, CASR, PRKAR1A, CXADR, PTHLH, PTH
11breast cancer30.5PTHLH, PTH1R, CYP27B1, CYP24A1, STC1
12myeloma30.4TNFRSF11A, TNFSF11, PTHLH, ALPL
13hypoparathyroidism30.4PRKAR1A, CASR, CALCA, NR1I3, FGF23, CXADR
14thyroiditis30.4CALCA
15hyperphosphatemia30.3ALPL, PTH, FGF23, CASR
16osteosclerosis30.2TNFSF11, PTH, ALPL
17hypervitaminosis d30.2CYP27B1, FGF23
18bone carcinoma30.2PTHLH, TNFSF11, TNFRSF11A
19prostate cancer30.1CASR, TNFRSF11A, TNFSF11, CYP24A1, CYP27B1, CXADR
20hepatocellular carcinoma30.1TNFSF11, STC1, NR1I3, CYP27B1, CXADR, ALPL
21hypophosphatasia30.1ALPL
22osteoporosis30.1PTHLH, PTH1R, CXADR, FGF23, CYP27B1, CYP24A1
23hypophosphatemia30.1ALPL, PTH, PTHLH, FGF23, CYP27B1, CALCA
24renal osteodystrophy30.0CALCA, CASR, FGF23, PTH, ALPL
25calcinosis30.0CASR, FGF23, PTH, ALPL
26melanoma30.0TNFSF11, NR1I3, CYP24A1, CYP27B1, CXADR
27osteopetrosis30.0TNFSF11, TNFRSF11A
28rheumatoid arthritis30.0CYP27B1, TNFSF11, TNFRSF11A
29graves' disease30.0CASR, CYP27B1, FGF23
30osteomalacia29.8ALPL, PTH, PTHLH, PTH1R, FGF23, CYP27B1
31paget's disease of bone29.8CALCA, TNFRSF11A, ALPL
32nephrolithiasis29.8CASR, NR1I3, FGF23, PTH
33hyperthyroidism29.8ALPL, PTH, FGF23
34diabetes insipidus29.8AVPR2
35cushing's syndrome29.8AVPR2, PRKAR1A, CALCA
36rickets29.8PTH, CYP27B1, CASR
37hyperparathyroidism, neonatal29.6CASR, PRKAR1A, NR1I3, CXADR
38osteitis fibrosa29.6CASR, PTH, ALPL
39pseudohypoparathyroidism29.6CALCA, PTH1R, PTHLH, PTH
40fibrous dysplasia29.6FGF23, ALPL
41giant cell tumor29.6CALCA, TNFRSF11A, TNFSF11, FGF23
42thyroid cancer29.6PTH, PRKAR1A, CALCA
43wermer syndrome29.6PTH, PRKAR1A, CASR
44hyperostosis29.6FGF23
45colon cancer29.6CASR, CYP24A1, CYP27B1, CXADR
46thyroid medullary carcinoma29.6PRKAR1A, CASR, CALCA
47psoriasis29.6CYP24A1, CYP27B1
48primary hyperoxaluria29.6CALCA, PTH, ALPL
49pheochromocytoma29.6STC1, CALCA
50acromegaly29.6PRKAR1A

Graphical network of the top 20 diseases related to Hypercalcemia:



Diseases related to hypercalcemia

Clinical Features for Hypercalcemia

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Drugs & Therapeutics for Hypercalcemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hypercalcemia

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22GTR
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Genetic tests related to Hypercalcemia:

id Genetic test Affiliating Genes
1 Hypercalcemia22

Anatomical Context for Hypercalcemia

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32MalaCards
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MalaCards organs/tissues related to Hypercalcemia:

32
Bone, Kidney, Lung, T cells, Breast, Thyroid, B cells, Liver, Prostate, Ovary, Colon, Pancreas, Myeloid, Bone marrow, Pituitary, Tongue, Endothelial, Skin, Thymus, Heart, Testes, Testis, Pancreatic islet, Lymph node

Animal Models for Hypercalcemia or affiliated genes

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36MGI
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Publications for Hypercalcemia

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50PubMed
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Articles related to Hypercalcemia:

(show top 50)    (show all 1160)
idTitleAuthorsYear
1
Bisphosphonates for treatment of severe idiopathic infantile hypercalcemia. (23485530)
2013
2
Ovarian carcinoma producing parathyroid hormone-related protein causing hypercalcemia and metastatic calcification detected on (18)F-FDG PET-CT. (24379537)
2013
3
Calcitriol-induced hypercalcemia in a patient with granulomatous mycosis fungoides and end-stage renal disease. (24175265)
2013
4
Familial hypocalciuric hypercalcemia: an atypical presentation. (22789152)
2013
5
Identification of AP2S1 Mutation and Effects of Low Calcium Formula in an Infant With Hypercalcemia and Hypercalciuria. (24081735)
2013
6
Hypercalcemia due to subcutaneous fat necrosis in a newborn after total body cooling. (22352980)
2013
7
Severe hypercalcemia unmasked by Vitamin D in a patient with sarcoidosis. (24049278)
2013
8
Idiopathic infantile hypercalcemia or an extrapulmonary complication of tuberculosis? (23581265)
2013
9
Flare hypercalcemia after letrozole in a patient with liver metastasis from breast cancer: a case report. (21970715)
2011
10
Sotos syndrome, infantile hypercalcemia, and nephrocalcinosis: a contiguous gene syndrome. (21597970)
2011
11
A case of metastatic mucoepidermoid carcinoma complicated by resistant hypercalcemia. (21603243)
2011
12
Increased RANKL and IL-6 levels might result in high bone turnover in a case of a CD34+/CD117+/myeloperoxidase(+dim) acute myeloid leukemia presenting with severe hypercalcemia and lumbar spine fractures. (21802729)
2011
13
Hypercalcemia of malignancy in a cat with bronchogenic adenocarcinoma. (20610700)
2010
14
Identification and functional analysis of novel calcium-sensing receptor gene mutation in familial hypocalciuric hypercalcemia. (20697181)
2010
15
Hypercalcemia of primary hyperparathyroidism was treated by cinacalcet in a patient with liver cirrhosis. (18561096)
2009
16
Aggressive small cell carcinoma of the ovary, hypercalcemic type with hypercalcemia in pregnancy, treated with conservative surgery and chemotherapy. (19893424)
2009
17
Involvement of molecular mimicry between human T-cell leukemia virus type 1 gp46 and osteoprotegerin in induction of hypercalcemia. (19134004)
2009
18
Hypercalcemia associated with squamous cell carcinoma arising in pyoderma chronica. (19785712)
2009
19
Idiopathic infantile hypercalcemia and renal involvement. (17978858)
2008
20
Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia]. (18939454)
2008
21
Coexisting primary hyperparathyroidism and sarcoidosis in a patient with severe hypercalcemia. (18385529)
2008
22
Hypercalcemia and multiple osteolytic lesions associated with proinflammatory cytokines in a patient with acute lymphoblastic leukemia]. (17695305)
2007
23
Cinacalcet for the treatment of hypercalcemia in renal transplanted patients with secondary hyperparathyroidism. (17889155)
2007
24
Hypercalcemia induced by ovarian clear cell carcinoma producing all transcriptional variants of parathyroid hormone-related peptide gene during pregnancy. (16956653)
2006
25
A case report of familial benign hypocalciuric hypercalcemia: a mutation in the calcium-sensing receptor gene. (16642557)
2006
26
Metastatic primitive neuroectodermal tumor presenting as acute renal failure and hypercalcemia. (15786830)
2005
27
Macrophage inflammatory protein-1alpha induces hypercalcemia in adult T-cell leukemia. (15176993)
2004
28
Nephrocalcinosis in a 2-month-old girl suffering from a mild variant of idiopathic infantile hypercalcemia. (15865256)
2004
29
Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia. (14625199)
2004
30
Effect of intravenous bisphosphonates on release of basic fibroblast growth factor in serum of patients with cancer-associated hypercalcemia. (12005179)
2002
31
Acute megakaryocytic leukemia presenting as hypercalcemia with skeletal lytic lesions. (12225399)
2002
32
Rapidly relapsing squamous cell carcinoma of the renal pelvis associated with paraneoplastic syndromes of leukocytosis, thrombocytosis and hypercalcemia. (11490218)
2001
33
Humoral hypercalcemia of malignancy in squamous cell carcinoma of the skin: parathyroid hormone--related protein as a cause. (11284521)
2001
34
Giant mediastinal parathyroid adenoma in a woman with hypercalcemia. (11595856)
2001
35
Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy. (10706080)
2000
36
Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol. (10048291)
1999
37
Humoral hypercalcemia associated with a uterine fibroid. (10215576)
1999
38
A novel mutation (L174R) in the Ca2+-sensing receptor gene associated with familial hypocalciuric hypercalcemia. (9298824)
1997
39
Pseudotumor cerebri and hypercalcemia resulting from vitamin A toxicity. (8604874)
1996
40
Squamous cell carcinoma arising from giant porokeratosis: a case with extensive metastasis and hypercalcemia. (8609268)
1996
41
Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate. (8156530)
1994
42
Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. (7916660)
1993
43
Hypercalcemia in breast cancer. (8375111)
1993
44
Intravenous pamidronic acid in hypercalcemia due to parathyroid carcinoma. (1820495)
1991
45
Calcium regulation of parathyroid and C cell function in familial benign hypercalcemia. (2028833)
1991
46
Hypercalcemia and ectopic secretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone. (2215618)
1990
47
Treatment of cancer-related hypercalcemia. (2185550)
1990
48
Hypercalcemia in association with mesoblastic nephroma: report of a case and review of the literature. (3022225)
1986
49
Squamous carcinoma model of humoral hypercalcemia of malignancy. (6499773)
1984
50
Fasting hypoglycemia, hypercalcemia and hyperprolactinemia. Multiple endocrine neoplasia, type 1? (4372884)
1974

Genetic Variations for Hypercalcemia

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Expression for genes affiliated with Hypercalcemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypercalcemia

Search GEO for disease gene expression data for Hypercalcemia.

Pathways for genes affiliated with Hypercalcemia

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Hypercalcemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CALCA, CASR, AVPR2, PTH1R, PTHLH, PTH
2
Hide members
10.5CALCA, CASR, PRKAR1A, FGF23, AVPR2, PTH1R
310.5ALPL, PTH, PTHLH, PTH1R
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5PTH, PTH1R, CYP27B1, CYP24A1, TNFSF11, TNFRSF11A
510.5NR1I3, CYP24A1, CYP27B1
6
Vitamin D2 (ergocalciferol) metabolism
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10.5CYP24A1, CYP27B1, PTH
7
Hide members
10.5PTH, PTHLH, PTH1R
8
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.5TNFSF11, PRKAR1A, PTH1R, PTHLH, PTH
910.5TNFSF11, FGF23, PTH1R, PTH
1010.5TNFSF11, TNFRSF11A

Compounds for genes affiliated with Hypercalcemia

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Hypercalcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1vitamin d4411.0CALCA, CASR, TNFSF11, CYP24A1, PRKAR1A, NR1I3
225-hydroxyvitamin d4411.0CALCA, CASR, TNFSF11, CYP24A1, CYP27B1, FGF23
31,25 dihydroxy vitamin d34411.0CYP27B1, CYP24A1, NR1I3, TNFSF11, TNFRSF11A, CASR
4cyclic amp44 2412.0PRKAR1A, NR1I3, CALCA, CYP27B1, PTH1R, PTHLH
5calcium44 49 11 2414.0ALPL, SPG7, PTH, CASR, CALCA, TNFRSF11A
6phosphorus4411.0PTH, PTHLH, FGF23, CYP27B1, NR1I3, CASR
7calcitriol44 59 11 2414.0TNFRSF11A, CASR, CALCA, TNFSF11, CYP24A1, CYP27B1
8pamidronate44 49 1112.9PTHLH, PTH, CASR, TNFSF11, CALCA
9cinacalcet44 28 1112.9NR1I3, PRKAR1A, CXADR, CASR, CALCA
10hydroxyapatite4410.9PTHLH, ALPL, FGF23, CASR, TNFSF11, TNFRSF11A
11forskolin44 49 1112.9PRKAR1A, CALCA, PTH, PTH1R
12alfacalcidol44 59 1112.9CYP24A1, CALCA, NR1I3, CYP27B1
13adenylate4410.9PRKAR1A, PTH, CXADR, CALCA, PTHLH, PTH1R
14pge24410.9PTH1R
15dexamethasone44 49 28 1113.9TNFSF11, STC1, NR1I3, PTH1R, PTH, CYP24A1
16neomycin4410.9CASR, PTHLH, PRKAR1A, NR1I3, CXADR
17steroid4410.9CXADR, STC1, CYP27B1, CYP24A1, PRKAR1A, NR1I3
18eb 108944 5911.9CYP27B1, PTHLH, CYP24A1, NR1I3
19lysine4410.9CXADR, AVPR2, SPG7, CYP27B1, NR1I3, CASR
20l-amino acid4410.9CXADR, NR1I3, PRKAR1A, CASR
21potassium44 11 2412.9CASR, TNFSF11, STC1, AVPR2
22ribonucleic acid4410.9NR1I3, CASR, PTH1R, CXADR, PTHLH, PTH
23strontium ranelate4410.9TNFSF11, CASR, CALCA
24alendronate44 49 1112.9PTHLH, PTH, TNFSF11, CALCA
25denosumab44 1111.9TNFSF11, TNFRSF11A, CALCA
26arginine4410.9NR1I3, CASR, PRKAR1A, PTH, FGF23, CXADR
27creatinine4410.9PTH, PTHLH, FGF23, TNFSF11, CASR, SPG7
28nitric oxide44 11 2412.9PTH, CASR, CALCA, PTH1R, CXADR, TNFSF11
2924,25-dihydroxyvitamin d34410.8CYP24A1, CYP27B1, CALCA
30paricalcitol44 1111.8CYP24A1, CYP27B1, PTH
31teriparatide44 1111.8CALCA, PTH1R, TNFSF11
32tyrosine4410.8CASR, CYP27B1, TNFRSF11A, NR1I3, FGF23, CXADR
33gadolinium4410.8PRKAR1A, CASR, NR1I3
34calcium carbonate4410.8CALCA, PTHLH, PTH
35estradiol44 11 2412.8PTHLH, NR1I3, STC1
36tartrate4410.8PTHLH, TNFSF11, CALCA
37phenylalanine4410.8CASR, NR1I3, FGF23, CXADR, ALPL
38serine4410.8PTHLH, PTH1R, CXADR, FGF23, CASR, TNFRSF11A
39clodronate44 49 1112.7PTHLH, CALCA, TNFSF11
40sodium44 2411.7TNFSF11, NR1I3, AVPR2, CASR
41calcipotriol44 59 28 1113.7CYP27B1, CYP24A1, NR1I3
42glutamate4410.7NR1I3, PRKAR1A, CASR, SPG7, CALCA, AVPR2
43zoledronic acid4410.7PTHLH, TNFSF11, CALCA
44deoxypyridinoline4410.6PTH, TNFSF11, CALCA
45magnesium44 11 2412.6PRKAR1A, ALPL, PTH, PTHLH, NR1I3, CASR
46retinoic acid44 2411.6CYP24A1, CYP27B1, CXADR, ALPL, PTHLH, PTH1R
47testosterone44 59 11 2413.5PTHLH, CYP27B1, NR1I3, TNFSF11, CALCA, PTH
48Calcidiol11 2411.5CYP24A1, CYP27B1
49calcifediol5910.4NR1I3, CYP27B1
50ibmx44 28 5912.2PTH, PTHLH, PTH1R, CALCA

GO Terms for genes affiliated with Hypercalcemia

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16Gene Ontology
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Cellular components related to Hypercalcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.5ALPL, PTH, PTHLH, CXADR, FGF23, STC1

Biological processes related to Hypercalcemia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:03328010.8ALPL, CYP27B1, CYP24A1, STC1
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.8PTH, PTHLH, PTH1R, CALCA
3vitamin D catabolic processGO:04236910.8CYP24A1, CYP27B1, FGF23
4ossificationGO:00150310.8CASR, TNFRSF11A, TNFSF11, STC1
5monocyte chemotaxisGO:00254810.8TNFSF11, TNFRSF11A, CALCA
6bone resorptionGO:04545310.8TNFSF11, PTH1R, PTH
7cell-cell signalingGO:00726710.8CALCA, TNFRSF11A, STC1, PTHLH, PTH
8positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.7TNFRSF11A, TNFSF11
9TNFSF11-mediated signaling pathwayGO:07184710.7TNFRSF11A, TNFSF11
10skeletal system developmentGO:00150110.7ALPL, PTH, PTHLH, PTH1R
11positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFRSF11A, TNFSF11
12positive regulation of cAMP biosynthetic processGO:03081910.7CALCA, PTHLH, PTH
13positive regulation of vitamin D 24-hydroxylase activityGO:01098010.7FGF23, CYP27B1
14cAMP metabolic processGO:04605810.6PTH, PTHLH
15cellular calcium ion homeostasisGO:00687410.6CASR, STC1, PTH
16vitamin D metabolic processGO:04235910.6CYP27B1, CYP24A1
17calcium ion homeostasisGO:05507410.5CYP27B1, TNFSF11
18mammary gland alveolus developmentGO:06074910.5TNFSF11, TNFRSF11A
19response to lipopolysaccharideGO:03249610.4TNFRSF11A, CYP27B1, ALPL
20decidualizationGO:04669710.2CYP27B1, STC1

Molecular functions related to Hypercalcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.5PTH, PTHLH
2hormone activityGO:00517910.2PTH, PTHLH, STC1, CALCA

Products for genes affiliated with Hypercalcemia

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Sources for Hypercalcemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet