Hypercalciuria malady

Wikipedia: Hypercalciuria or hypercalcinuria is the condition of elevated calcium in the urine. Chronic...⁴⁴ more...

MalaCards: Hypercalciuria is related to hypophosphatemic rickets with hypercalciuria and hereditary hypophosphatemic rickets with hypercalciuria. An important gene associated with Hypercalciuria is CLDN16 (claudin 16), and among its related pathways are Cell adhesion_Tight junctions and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds dmsa and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and monocytes, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

hypercalciuria 7 32 43

Diseases related to hypercalciuria by text searches and GeneDecks gene sharing:

(show top 50)    (show all 557)

id	Related Disease	Score	Top Affiliating Genes
1	hypophosphatemic rickets with hypercalciuria	33.3	FGF23, SLC34A3, SLC34A1
2	hereditary hypophosphatemic rickets with hypercalciuria	32.7	FGF23, SLC34A3, SLC34A1
3	hereditary hypophosphatemic rickets	32.0	FGF23, SLC34A3, SLC34A1
4	hypercalciuria, absorptive	31.7	VDR, CASR, HCA1
5	hypomagnesemia	31.1	REN, CLCNKB, CLDN16, CLDN19, BGLAP, MT-ND4L
6	nephrocalcinosis	30.8	LRP2, NAGLU, CLCNKB, CLDN16, CLCN5, CLDN19
7	dent disease	30.5	LRP2, REN, CLCNKB, CLDN16, CLCN5, CLCNKA
8	rickets	29.9	VDR, BGLAP, FGF23, IL6, ALB, CASR
9	bartter syndrome antenatal type 2	28.4	REN, KCNJ1, SLC12A1
10	nephrolithiasis	27.7	BSND, NAGLU, VDR, CLCNKB, CLDN16, CLCN5
11	root resorption	27.4	CLCN5, IL1B, CALCA, TNFSF11
12	hypoparathyroidism	26.9	NAGLU, VDR, BGLAP, FGF23, CASR, CALCA
13	pseudohypoaldosteronism	26.7	REN, KCNJ1, TRPV5, TRPC5, TRPV6, SLC12A1
14	bartter disease	26.5	REN, VDR, CASR, CALCA, PTH, SPG7
15	proteinuria	25.9	LRP2, REN, NAGLU, VDR, CLCN5, B2M
16	hypocalcemia	25.4	VDR, CLDN16, BGLAP, FGF23, ALB, CASR
17	hypercalcemia	23.3	KL, VDR, BGLAP, B2M, FGF23, METTL1
18	osteoporosis	20.3	KL, VDR, BGLAP, B2M, MIP, FGF23
19	hypertension	18.5	KL, REN, BSND, NAGLU, VDR, CLCNKB
20	hyperparathyroidism, neonatal severe primary	13.8	CASR, NR1I3, PRKAR1A
21	familial hypocalciuric hypercalcemia	13.8	CASR, SPG7, NR1I3
22	vitamin d-dependent rickets type ii	13.7	VDR, BGLAP, PTH
23	nephrogenic diabetes insipidus	13.7	MIP, AQP2, CASR, SLC12A1
24	bartter syndrome type 4	13.7	BSND, CLCNKB, CLCNKA
25	jansen's metaphyseal chondrodysplasia	13.7	FGF23, PTH, PTHLH
26	urinary tract obstruction	13.7	NAGLU, B2M, AMBP
27	metaphyseal chondrodysplasia	13.7	FGF23, PTH, PTHLH
28	bartter syndrome type 4b	13.7	CLCNKB, CLCNKA
29	parathyroid disorders	13.7	PTH, PTHLH
30	amyloid tumor	13.7	B2M, CALCA
31	idiopathic juvenile osteoporosis	13.7	BGLAP, CALCA, PTH
32	paget's disease of bone	13.7	BGLAP, B2M, CALCA
33	oncogenic osteomalacia	13.7	FGF23, CALCA, PTH
34	mucinous tubular and spindle renal cell carcinoma	13.7	NAGLU, CLCN5, B2M, SLC12A3
35	pseudohypoparathyroidism type ib	13.6	BGLAP, PTH, PTHLH
36	polycystic kidney disease, autosomal dominant	13.6	REN, AQP2, SLC12A1, ADCY10
37	renal tubular acidosis	13.6	B2M, ATP6V1B1, OCRL
38	bartter syndrome type 3	13.6	REN, CLCNKB, KCNJ1, SLC12A1, SLC12A3
39	familial isolated hyperparathyroidism	13.6	CASR, PTH, GAST
40	oculocerebrorenal syndrome	13.6	LRP2, NAGLU, OCRL
41	aminoaciduria	13.6	CLCN5, B2M, OCRL, SLC34A1
42	mccune albright syndrome	13.6	BGLAP, FGF23, PTHLH, PRKAR1A, SLC34A1
43	x-linked hypophosphatemia	13.5	VDR, CLCN5, FGF23, CYP24A1, SLC34A3, SLC34A1
44	hypoparathyroidism, autosomal dominant	13.5	CASR, PTH
45	hyperostosis	13.5	KL, BGLAP, FGF23, PTH
46	bartter syndrome, type 2	13.5	REN, KCNJ1
47	parathyroid carcinoma	13.5	CASR, CALCA, PTH
48	osteitis fibrosa	13.5	BGLAP, B2M, CASR, CALCA, PTH
49	osteopenia/osteoporosis	13.5	BGLAP, CALCA, TNFSF11
50	tumoral calcinosis, hyperphosphatemic	13.5	KL, FGF23

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypercalciuria:

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MGI Mouse Phenotypes related to hypercalciuria:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	KL, LRP2, TRPV6, PRKAR1A, PTH
2	craniofacial phenotype	MP:0005382	9.5	PTH, LRP2, NAGLU, EDN1, PRKAR1A, CLCN5
3	hematopoietic system phenotype	MP:0005397	9.4	SLC12A1, PRKAR1A, PTHLH, PTH, TNFSF11, TRPV5
4	integument phenotype	MP:0010771	9.3	KCNJ1, CASR, CALCA, TRPV6, TNFSF11, PTHLH
5	hearing/vestibular/ear phenotype	MP:0005377	8.7	NAGLU, LRP2, VDR, ATP6V1B1, CALCA, EDN1
6	skeleton phenotype	MP:0005390	7.9	FGF23, CLCN5, VDR, NAGLU, SPG7, CASR
7	renal/urinary system phenotype	MP:0005367	7.3	LRP2, SLC12A3, WNK1, WNK4, SLC12A1, SLC34A1
8	reproductive system phenotype	MP:0005389	7.3	TNFSF11, CYP24A1, NR1I3, PRKAR1A, OCRL, SLC34A1
9	digestive/alimentary phenotype	MP:0005381	6.7	SLC34A3, LRP2, KL, VDR, B2M, FGF23
10	growth/size phenotype	MP:0005378	6.6	AQP2, IL6, FGF23, B2M, KCNJ1, VDR
11	behavior/neurological phenotype	MP:0005386	6.6	CASR, CALCA, TRPC5, TRPV6, TNF, PTHLH
12	immune system phenotype	MP:0005387	6.0	PTHLH, PTH, TNFSF11, TNF, TRPV6, TRPV5
13	mortality/aging	MP:0010768	6.0	AGTR1, EDN1, NR1I3, PTH, PRKAR1A, OCRL
14	nervous system phenotype	MP:0003631	5.8	NAGLU, BSND, REN, KL, LRP2, B2M
15	cardiovascular system phenotype	MP:0005385	5.6	B2M, FGF23, IL1B, IL6, KCNJ1, NPPA
16	homeostasis/metabolism phenotype	MP:0005376	4.6	KL, REN, BSND, VDR, CLDN16, CLCN5

Articles related to hypercalciuria:

(show top 50)    (show all 85)

id	Title	Authors	Year	Affiliating Genes
1	A novel mutation of the claudin 16 gene in familial h ypomagnesemia with hypercalciuria and nephrocalcinosis mimicking rickets. (21848011)	Kasapkara C.S.... Hasanoglu A.	2011	CLDN16
2	Hypophosphatemic rickets with hypercalciuria due to m utation in SLC34A3/type IIc sodium-phosphate cotransporter: presentation as hyp ercalciuria and nephrolithiasis. (19820004)	Tencza A.L.... Levine M.A.	2009	SLC34A3
3	TRPV5 gene polymorphisms in renal hypercalciuria. (19131347)	Renkema K.Y.... Hoenderop J.G.	2009	TRPV5
4	Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): compound heterozygous mutation in the claudin 16 (CLDN16) gene. (18816383)	Hampson G.... Scoble J.	2008	CLDN16
5	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis in 2 sisters. (18327378)	Al-Elq A.H.	2008	CLDN16
6	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: report of three Turkish siblings. (18253757)	Peru H.... Konrad M.	2008	CLDN16
7	A novel missense mutation in SLC34A3 that causes here ditary hypophosphatemic rickets with hypercalciuria in humans identifies threon ine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc . (18480181)	Jaureguiberry G.... Bergwitz C.	2008	SLC34A3
8	Update on primary hypercalciuria from a genetic perspective. (18343451)	Vezzoli G.... Gambaro G.	2008	VDR, CASR, CLCN5
9	CLDN16 genotype predicts renal decline in familial hypomagnesemia with hypercalciuria and nephrocalcinosis. (18003771)	Konrad M.... Schaller A.	2008	CLDN16
10	R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria. (17332735)	Vezzoli G.... Soldati L.	2007	CASR
11	WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. (17018846)	Jiang Y.... Peng J.B.	2007	TRPV5, WNK4
12	An unusual patient with hypercalciuria, recurrent nephrolithiasis, hypomagnesemia and G227R mutation of Paracellin-1. An unusual patient with hypercalciuria and hypomagnesemia unresponsive to thiazide diuretics. (16804318)	Kutluturk F.... Ozbey N.	2006	CLDN16
13	Hypercalciuria in patients with CLCN5 mutations. (16807762)	Ludwig M.... Bokenkamp A.	2006	CLCN5
14	SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium- phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. (16358214)	Bergwitz C.... Jueppner H.	2006	SLC34A3
15	Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. (16358215)	Lorenz-Depiereux B.... Strom T.M.	2006	FGF23, SLC34A3
16	A family with autosomal dominant hypocalcaemia with hypercalciuria (ADHH): mutational analysis, phenotypic variability and treatment challenges. (16128246)	Burren C.P.... Thakker R.V.	2005	CASR
17	Renal function in space: the link between osteoporosis, hypercalciuria, and aquaporins. (15648031)	Gaspare De Santo N.... Drummer C.	2005	AQP2, MIP
18	Hypomagnesemia with hypercalciuria and nephrocalcinosis: case report and a family study. (15856319)	Tasic V.... Konrad M.	2005	CLDN16
19	Hypercalciuria (16357816)	PAcrimenis P.... Vantyghem M.C.	2005	CASR
20	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis associated with CLDN16 mutations. (16047219)	Kang J.H.... Choi Y.	2005	CLDN16
21	Hypercalciuria and kidney calcifications in terminal 4q deletion syndrome: further evidence for a putative gene on 4q. (15057984)	GiuffrA" M.... Corsello G.	2004	CALCA, CASR
22	Peripheral blood monocyte vitamin D receptor levels are elevated in patients with idiopathic hypercalciuria. (15472188)	Favus M.J.... Coe F.L.	2004	VDR
23	Inherited hypercalciuric syndromes: Dent's disease (CLC-5) and familial hypomagnesemia with hypercalciuria (paracellin-1). (14730510)	Knohl S.J.... Scheinman S.J.	2004	CLDN16
24	Urinary excretion of endothelin-1 in children with absorptive idiopathic hypercalciuria. (14523636)	Nicolaidou P.... Gourgiotis D.	2003	EDN1
25	The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover. (12674322)	Silva I.V.... Guggino S.E.	2003	BGLAP
26	Loss of heterozygosity in parathyroid glands of familial hypercalcemia with hypercalciuria and point mutation in calcium receptor. (12161540)	Szabo E.... Rastad J.	2002	PRKAR1A
27	Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. (11518780)	Weber S.... Konrad M.	2001	CLDN16
28	No evidence for point mutations of the calcium-sensing receptor in familial idiopathic hypercalciuria. (11733622)	Lerolle N.... Rondeau E.	2001	PRKAR1A, CASR
29	Hereditary hypophosphatemic rickets with hypercalciuria is not caused by mutations in the Na/Pi cotransporter NPT2 gene. (11181798)	Jones A.... Tenenhouse H.	2001	SLC34A1
30	Autosomal recessive hypophosphataemic rickets with hypercalciuria is not caused by mutations in the type II renal sodium/phosphate cotransporter gene. (11208993)	van den Heuvel L.... Monnens L.	2001	SLC34A1
31	Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. (10878661)	Weber S.... Konrad M.	2000	CLDN16
32	Isolated hypercalciuria with mutation in CLCN5: relevance to idiopathic hypercalciuria. (10620204)	Scheinman S.J.... Thakker R.V.	2000	CLCN5
33	Evaluation of the calcium-sensing receptor gene in idiopathic hypercalciuria and calcium nephrolithiasis. (10886547)	Petrucci M.... Bonnardeaux A.	2000	CASR, NR1I3
34	Microscopic nephrocalcinosis and hypercalciuria in ne phrotic syndrome. (11112210)	Mocan H.... Kuzey G.M.	2000	ALB
35	Atrial natriuretic peptide in children with idiopathic hypercalciuria. (10955944)	Nicolaidou P.... Karpathios T.	2000	REN
36	Investigation of relationship between idiopathic hypercalciuria and urinary enzyme activities. (11229247)	Kavukcu S.... Tavli V.	1998	NAGLU, SLPI, SLC17A5
37	4q33-qter deletion and absorptive hypercalciuria: report of two unrelated girls. (9637423)	Imamura K.... Tochimaru H.	1998	HCA1
38	Normal vitamin D receptor concentration and responsiveness to 1, 25-dihydroxyvitamin D3 in skin fibroblasts from patients with absorptive hypercalciuria. (9705566)	Zerwekh J.E.... Pak C.Y.	1998	VDR
39	Mutations of CLCN5 in Japanese children with idiopathic low molecular weight proteinuria, hypercalciuria and nephrocalcinosis. (9328929)	Akuta N.... Thakker R.V.	1997	CLCN5
40	Low bone mineral density and peripheral blood monocyte activation profile in calcium stone formers with idiopathic hypercalciuria. (8989228)	Ghazali A.... Fournier A.	1997	TNF, IL6, IL1B
41	Acute gentamicin-induced hypercalciuria and hypermagn esiuria in the rat: dose-response relationship and role of renal tubular injury . (9351517)	Parsons P.P.... Old S.	1997	NAGLU
42	Infantile hypophosphatasia: treatment options to control hypercalcemia, hypercalciuria, and chronic bone demineralization. (9152296)	Barcia J.P.... Langman C.B.	1997	CALCA
43	Bone mineral density in pediatric patients with idiop athic hypercalciuria. (9323283)	GarcA-a-Nieto V.... Rodrigo M.D.	1997	BGLAP
44	Renal function in children with hypercalciuria. (9339112)	Tekin N.... Torun M.	1997	NAGLU
45	Bartter's syndrome, hypokalemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. (8640224)	Simon D.B.... Lifton R.P.	1996	SLC12A1
46	Osteocalcin response to calcium-restricted diet: a helpful tool for the workup of hypercalciuria. (8854076)	Strohmaier W.L.... Bichler K.H.	1996	BGLAP
47	A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. (8813042)	Pearce S.H.S.... Thakker R.V.	1996	CASR
48	Hypercalciuria in children severely affected with osteogenesis imperfecta. (2066859)	Chines A.... Whyte M.P.	1991	BGLAP
49	Atrial natriuretic factor levels in renal stone patients with idiopathic hypercalciuria and in healthy controls: the effect of an oral calcium load. (2137191)	Halabe A.... Sutton R.A.	1990	NPPA
50	Increased monocyte interleukin-1 activity and decreas ed vertebral bone density in patients with fasting idiopathic hypercalciuria. (2370292)	Pacifici R.... Hruska K.	1990	BGLAP

Genes related to hypercalciuria according to GeneCards:

(show top 50)    (show all 54)

id	Symbol	Description	Score	GeneCards Section Context
1	CLDN16	claudin 16	11.1	Aliases & Descriptions, Publications, Summaries
2	SLC34A3	solute carrier family 34 (sodium phosphate), member 3	11.1	Summaries, Publications
3	ADCY10	adenylate cyclase 10 (soluble)	11.1	Summaries, Publications
4	HCA1	Hypercalciuria, absorptive, 1	11.1	Publications, Aliases & Descriptions
5	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	11.1	Summaries
6	CLDN19	claudin 19	11.0	Summaries
7	SLC34A1	solute carrier family 34 (sodium phosphate), member 1	11.0	Publications
8	FGF23	fibroblast growth factor 23	11.0	Publications
9	CASR	calcium-sensing receptor	11.0	Publications
10	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
11	CLCN5	chloride channel, voltage-sensitive 5	11.0	Publications
12	BSND	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	11.0
13	CLCNKB	chloride channel, voltage-sensitive Kb	11.0
14	MIP	major intrinsic protein of lens fiber	11.0	Publications
15	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0	Publications
16	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
17	AQP2	aquaporin 2 (collecting duct)	11.0	Publications
18	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications
19	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	11.0
20	PTH	parathyroid hormone	11.0	Publications
21	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0
22	SPG7	spastic paraplegia 7 (pure and complicated autosomal recessive)	11.0	Publications
23	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
24	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0	Publications
25	AMBP	alpha-1-microglobulin/bikunin precursor	11.0
26	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
27	B2M	beta-2-microglobulin	11.0
28	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
29	PTHLH	parathyroid hormone-like hormone	11.0
30	REN	renin	11.0	Publications
31	LRP2	low density lipoprotein receptor-related protein 2	11.0
32	METTL1	methyltransferase like 1	11.0	Publications
33	TRPV5	transient receptor potential cation channel, subfamily V, member 5	11.0	Publications
34	TRIM13	tripartite motif containing 13	11.0	Publications
35	CLCNKA	chloride channel, voltage-sensitive Ka	11.0
36	WNK4	WNK lysine deficient protein kinase 4	11.0	Publications
37	TRPV6	transient receptor potential cation channel, subfamily V, member 6	11.0	Publications
38	KL	klotho	11.0	Publications
39	CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	11.0	Publications
40	OCRL	oculocerebrorenal syndrome of Lowe	11.0
41	TJP1	tight junction protein 1	11.0	Publications
42	TRPC5	transient receptor potential cation channel, subfamily C, member 5	11.0	Publications
43	WNK1	WNK lysine deficient protein kinase 1	11.0	Publications
44	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
45	GAST	gastrin	11.0	Publications
46	NPPA	natriuretic peptide A	11.0	Publications
47	AGTR1	angiotensin II receptor, type 1	11.0
48	EDN1	endothelin 1	11.0	Publications
49	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
50	MT-ND4L	mitochondrially encoded NADH dehydrogenase 4L	11.0	Publications

Pathways related to hypercalciuria according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion_Tight junctions41	9.9	CLDN16, CLDN19, TJP1, WNK4
2	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.8	PTH, VDR, PTHLH, PRKAR1A, BGLAP, TNFSF11
3	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.8	PTHLH, PRKAR1A, PTH, TNFSF11, BGLAP, VDR
4	Cell adhesion Tight junctions10	9.6	WNK4, TJP1, CLDN19, CLDN16
5	Selected targets of GCR-alpha10	8.9	IL6, NR1I3, TNFSF11, IL1B
6	Rheumatoid arthritis20	8.3	IL1B, IL6, TNF, TNFSF11, ATP6V1B1
7	Immune response IL-1 signaling pathway10	8.3	IL1B, IL6, TNF, EDN1
8	Immune response_IL-1 signaling pathway41	8.2	EDN1, IL6, IL1B, TNF
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	7.9	BGLAP, IL1B, IL6, CALCA, TNF, TNFSF11
10	Transcription Role of VDR in regulation of genes involved in osteoporosis10	7.8	CYP24A1, PTH, TNFSF11, IL6, CALCA, IL1B

Compounds related to hypercalciuria according to GeneDecks:

(show top 50)    (show all 237)

id	Compound	Score	Top Affiliating Genes
1	dmsa32	10.1	CALCA, AMBP, B2M, NAGLU, VDR
2	aprotinin32 9 9	12.1	LRP2, SLPI, AMBP, NAGLU
3	alfacalcidol32 9 9	12.0	VDR, SLPI, CYP24A1, CALCA, BGLAP
4	24,25-dihydroxyvitamin d332	10.0	ADCY10, CYP24A1, CALCA, VDR, BGLAP
5	alendronate32 9 9	11.7	CALCA, TNFSF11, PTH, PTHLH, SLPI, VDR
6	phosphorus32	9.7	NAGLU, VDR, B2M, FGF23, CASR, CALCA
7	hanp32	9.6	REN, B2M, VDR, NPPA, EDN1, AMBP
8	25-hydroxyvitamin d32	9.6	PTHLH, CYP24A1, SLPI, PTH, TNFSF11, VDR
9	fluoride32	9.6	NAGLU, CALCA, SLPI, B2M, SLC17A5, ADCY10
10	glucose32	9.5	PTH, GAST, PRKAR1A, PTHLH, TJP1, MIP
11	chlorine32 18	10.4	BSND, CLCN5, CLCNKA, B2M, CALCA, CLCNKB
12	pamidronate32 9 9	11.3	BGLAP, B2M, IL6, CASR, CALCA, TNFSF11
13	captopril32 42 9 9	12.3	REN, NPPA, CALCA, ALB, B2M
14	thiazide32	9.3	REN, VDR, BGLAP, CASR, CALCA, AGTR1
15	hydrochlorothiazide32 34 9 18 9	13.2	REN, VDR, CLDN16, BGLAP, AQP2, ALB
16	inulin32	9.2	TJP1, ALB, REN, NAGLU, B2M, AMBP
17	pge232	9.1	REN, AQP2, CASR, TNFSF11, CYP24A1, EDN1
18	1,25 dihydroxy vitamin d332	9.0	SLC34A1, VDR, BGLAP, FGF23, CASR, CALCA
19	clodronate32 9 9	11.0	PTHLH, BGLAP, IL1B, IL6, SLPI, CALCA
20	arginine32	8.9	FGF23, CASR, AQP2, MIP, KCNJ1, VDR
21	testosterone32 9 18 9	11.9	SLPI, PTHLH, TNFSF11, BGLAP, PTH, NR1I3
22	enalapril32 9 9	10.7	NPPA, REN, NAGLU, AMBP, ALB, EDN1
23	urea32 9 18 9	11.7	NAGLU, B2M, MIP, AQP2, AMBP, ALB
24	inositol 1,4,5 trisphosphate32	8.7	CASR, OCRL, TRPV6, PTH, ADCY10, NR1I3
25	furosemide32 42 34 9 18 9	13.7	REN, BSND, NAGLU, BGLAP, AQP2, ALB
26	nifedipine32 9 9	10.7	GAST, REN, NPPA, AGTR1, EDN1, PTHLH
27	creatinine32	8.5	REN, NAGLU, VDR, CLCN5, FGF23, AQP2
28	nacl32	8.5	AQP2, MIP, CASR, NPPA, SLPI, SLC12A1
29	thyroxine32 18	9.4	ALB, REN, GAST, SLC17A5, PTH, CALCA
30	forskolin32 42 9 9	11.1	CALCA, AGTR1, CYP24A1, PTHLH, PTH, TNFSF11
31	chloride32	8.1	SLC17A5, WNK1, WNK4, SLC12A3, SLC12A1, REN
32	hydrocortisone32 9 9	9.6	BGLAP, IL1B, PTHLH, IL6, AQP2, GAST
33	norepinephrine32 9 18 9	10.6	PTHLH, IL6, AGTR1, REN, NPPA, SLPI
34	magnesium32 9 18 9	10.6	PRKAR1A, SLPI, SLC12A1, SLC17A5, WNK1, WNK4
35	prostaglandin32	7.3	NPPA, AGTR1, PTH, AMBP, IL1B, PTHLH
36	alanine32	7.2	GAST, SLC17A5, SLC12A3, SLPI, AGTR1, NR1I3
37	genistein32 9 18 9	9.8	SLPI, VDR, B2M, AGTR1, EDN1, CYP24A1
38	potassium32 9 18 9	9.8	PTH, TNFSF11, CASR, ALB, AMBP, AQP2
39	indomethacin32 9 9	8.8	CALCA, TNF, TNFSF11, TJP1, PTHLH, EDN1
40	cycloheximide32	6.8	TJP1, TNF, IL6, IL1B, B2M, TNFSF11
41	cyclosporin a32 42	7.7	NR1I3, TNFSF11, TNF, CALCA, CASR, AMBP
42	vitamin d32	6.5	LRP2, NAGLU, VDR, BGLAP, B2M, FGF23
43	histamine32 18	7.5	ADCY10, SLPI, EDN1, TJP1, TNF, ALB
44	dexamethasone32 42 34 9 9	10.4	IL1B, MIP, BGLAP, VDR, REN, GAST
45	serine32	6.2	AGTR1, VDR, AMBP, CASR, TNFSF11, TNF
46	calcitriol32 42 9 18 9	9.9	GAST, SLC34A1, SLPI, LRP2, NR1I3, CYP24A1
47	vegf32	5.9	IL6, GAST, SLPI, PTH, TNF, TNFSF11
48	nitric oxide32 9 18 9	8.7	CALCA, IL6, PTHLH, EDN1, AGTR1, IL1B
49	sodium32 18	6.6	WNK4, WNK1, SLC17A5, SLC12A3, SLC12A1, SLC34A1
50	calcium32 9 18 9	6.7	REN, KL, LRP2, CLDN16, GAST, ADCY10

Cellular components related to hypercalciuria according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	apical plasma membrane	GO:016324	9.8	LRP2, ATP6V1B1, AQP2, TRPV5, SLC34A3, SLC12A3
2	basolateral plasma membrane	GO:016323	9.5	SLC34A1, TJP1, AQP2, ATP6V1B1, CLDN19, BSND
3	integral to plasma membrane	GO:005887	7.0	KL, BSND, SLC12A3, SLC34A1, AGTR1, TNFSF11
4	extracellular region	GO:005576	6.2	ALB, KL, BGLAP, B2M, FGF23, IL1B
5	extracellular space	GO:005615	6.1	EDN1, KL, REN, BGLAP, B2M, FGF23

Biological processes related to hypercalciuria according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of vitamin D 24-hydroxylase activity	GO:010980	10.5	FGF23, VDR
2	vitamin D receptor signaling pathway	GO:070561	10.4	VDR, CYP24A1
3	sodium ion transport	GO:006814	10.3	SLC34A3, SLC34A1, SLC12A1, SLC12A3
4	regulation of cellular process	GO:050794	10.2	WNK1, WNK4
5	cAMP metabolic process	GO:046058	10.2	PTH, PTHLH
6	excretion	GO:007588	10.1	CLCNKB, AQP2, ATP6V1B1, KCNJ1, CLCNKA, CLCN5
7	renin-angiotensin regulation of aldosterone production	GO:002018	10.0	AGTR1, REN
8	vitamin D catabolic process	GO:042369	9.9	FGF23, CYP24A1
9	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	GO:051482	9.9	CALCA, EDN1, AGTR1
10	monocyte chemotaxis	GO:002548	9.8	TNFSF11, CALCA, IL6
11	response to vitamin D	GO:033280	9.7	BGLAP, IL1B, CYP24A1, LRP2
12	ion transport	GO:006811	9.6	WNK4, WNK1, SLC17A5, SLC12A3, SLC12A1, SLC34A3
13	aging	GO:007568	9.5	CALCA, AQP2, IL1B, VDR, KL, LRP2
14	sequestering of triglyceride	GO:030730	9.2	IL1B, TNF
15	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.2	TNF, IL1B
16	chronic inflammatory response to antigenic stimulus	GO:002439	9.0	IL1B, TNF
17	transmembrane transport	GO:055085	9.0	ALB, SLC17A5, SLC12A3, SLC12A1, SLC34A3, PRKAR1A

Molecular functions related to hypercalciuria according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated chloride channel activity	GO:005247	10.1	CLCNKB, CLCN5, CLCNKA
2	peptide hormone receptor binding	GO:051428	9.6	PTH, PTHLH, NPPA
3	hormone activity	GO:005179	8.8	KL, GAST, NPPA, EDN1, PTHLH, PTH