Hypercalciuria, Absorptive malady

MalaCards: Hypercalciuria, Absorptive, also known as hypercalciuria, is related to hypercalciuria and rickets. An important gene associated with Hypercalciuria, Absorptive is HCA1 (Hypercalciuria, absorptive, 1). The compounds 24,25-dihydroxyvitamin d3 and 22-oxacalcitriol have been mentioned in the context of this disorder.

OMIM: 143870

hypercalciuria, absorptive 33 32 hypercalciuria 43

Diseases related to hypercalciuria, absorptive by text searches and GeneDecks gene sharing:

(show top 50)    (show all 55)

id	Related Disease	Score	Top Affiliating Genes
1	hypercalciuria	33.8	ADCY10, HCA1, CASR, VDR
2	rickets	30.9	VDR, CASR
3	nephrolithiasis	28.4	ADCY10, CASR, VDR
4	hypercalcemia	28.4	VDR, CASR, ADCY10
5	hypoparathyroidism	26.5	CASR, VDR
6	hypocalcemia	25.7	VDR, CASR, ADCY10
7	osteoporosis	25.6	VDR, CASR, ADCY10
8	secondary hyperparathyroidism of renal origin	12.5	VDR, CASR
9	osteopenia/osteoporosis	12.5	VDR, CASR
10	hyperphosphatemia	12.5	VDR, CASR
11	urolithiasis	12.5	VDR, CASR
12	megakaryoblastic leukemia	12.5	VDR, ADCY10
13	renal osteodystrophy	12.5	CASR, VDR
14	hypophosphatemia	12.5	VDR, CASR
15	parathyroid adenoma	12.4	CASR, VDR
16	osteomalacia	12.4	CASR, VDR
17	humoral hypercalcemia of malignancy	12.4	CASR, ADCY10
18	paget's disease of bone	12.4	VDR, CASR
19	secondary syphilis	12.4	VDR, CASR
20	primary hyperparathyroidism	12.3	VDR, CASR
21	arterial calcification	12.3	VDR, CASR
22	gigantism	12.0	VDR, ADCY10
23	uremia	11.9	ADCY10, CASR, VDR
24	chronic kidney failure	11.9	VDR, CASR, ADCY10
25	hypothyroidism	11.9	ADCY10, CASR, VDR
26	graves' disease	11.9	VDR, CASR, ADCY10
27	hyperparathyroidism	11.9	ADCY10, CASR, VDR
28	periodontitis	11.8	ADCY10, CASR, VDR
29	blindness	11.8	VDR, CASR, ADCY10
30	thyroid carcinoma	11.7	ADCY10, CASR, VDR
31	primary hyperoxaluria	11.6	ADCY10, CASR, VDR
32	osteosarcoma	11.6	VDR, CASR, ADCY10
33	myocardial infarction	11.5	ADCY10, CASR, VDR
34	atherosclerosis	11.5	VDR, CASR, ADCY10
35	colon carcinoma	11.4	ADCY10, CASR, VDR
36	nephrocalcinosis	8.7
37	hypomagnesemia	8.5
38	hypophosphatemic rickets with hypercalciuria	8.3
39	hereditary hypophosphatemic rickets with hypercalciuria	7.9
40	dent disease	7.5
41	hereditary hypophosphatemic rickets	7.5
42	hypertension	6.1
43	hypomagnesemia primary	6.1
44	proteinuria	6.1
45	hypercalcinuria macular coloboma	5.2
46	manz syndrome	5.2
47	meier blumberg imahorn syndrome	5.2
48	osteogenesis imperfecta	5.2
49	pseudohypoaldosteronism	5.2
50	root resorption	5.2

Clinical features from OMIM: 143870

Approved drugs:

Drug clinical trials:

Genes related to hypercalciuria, absorptive according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	HCA1	Hypercalciuria, absorptive, 1	11.1	Aliases & Descriptions
2	ADCY10	adenylate cyclase 10 (soluble)	11.1
3	CASR	calcium-sensing receptor	11.0
4	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0

Compounds related to hypercalciuria, absorptive according to GeneDecks:

(show all 13)

id	Compound	Score	Top Affiliating Genes
1	24,25-dihydroxyvitamin d332	9.6	ADCY10, VDR
2	22-oxacalcitriol32	9.4	CASR, VDR
3	thiazide32	9.4	VDR, CASR
4	xbai32	9.4	VDR, CASR
5	hydrochlorothiazide32 34 9 18 9	13.3	CASR, VDR
6	25-hydroxyvitamin d32	9.3	VDR, CASR
7	phosphorus32	9.2	CASR, VDR
8	1,25 dihydroxy vitamin d332	9.0	CASR, VDR
9	inositol 1,4,5 trisphosphate32	9.0	ADCY10, CASR
10	pge232	8.7	ADCY10, CASR, VDR
11	adenylate32	8.6	VDR, CASR, ADCY10
12	arginine32	8.5	VDR, ADCY10, CASR
13	glutamate32	8.2	ADCY10, CASR, VDR

Biological processes related to hypercalciuria, absorptive according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular calcium ion homeostasis	GO:006874	9.1	VDR, CASR