MCID: HYP095
MIFTS: 56

Hypercholesterolemia malady

Summaries for Hypercholesterolemia

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21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products). The body needs this substance to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion. Too much cholesterol, however, increases a person's risk of developing heart disease.

MalaCards: Hypercholesterolemia, also known as elevated cholesterol, is related to familial hypercholesterolemia and atherosclerosis. An important gene associated with Hypercholesterolemia is ITIH4 (inter-alpha-trypsin inhibitor heavy chain family, member 4), and among its related pathways are Statin Pathway, Pharmacodynamics and Lipoprotein metabolism. The drugs psyllium and psyllium hydrocolloid and the compounds cholesterol and lipid have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Wikipedia:63 Hypercholesterolemia (also spelled hypercholesterolaemia) is the presence of high levels of cholesterol... more...

Description from OMIM:46 143890

Aliases & Classifications for Hypercholesterolemia

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21Genetics Home Reference, 46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

hypercholesterolemia 21 46 44 60
elevated cholesterol 21


Related Diseases for Hypercholesterolemia

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17GeneCards, 18GeneDecks
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Diseases in the Familial Hypercholesterolemia family:

hypercholesterolemia Hypercholesterolemia, Familial, 3
Hypercholesterolemia, Due to Ligand-Defective Apo B Hypercholesterolemia, Familial, Due to Ldlr Defect, Modifier of

Diseases related to Hypercholesterolemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1familial hypercholesterolemia31.9APOB, PCSK9, HMGCR, CETP, LDLR
2atherosclerosis31.2LDLR, LDLRAP1, CETP, HMGCR, ABCA1, LCAT
3hypertension30.8COG2, EPHX2, LPL, APOB, APOE, APOA1
4coronary artery disease30.8APOA2, APOE, APOA1, LCAT, COG2, APOB
5diabetes mellitus30.7COG2, LCAT, APOA1, APOE, APOA2, APOB
6familial combined hyperlipidemia30.6APOA1, APOE, APOB, HMGCR
7familial hyperlipidemia30.5LPL, APOB, APOA2, APOE, APOA1, LCAT
8obesity30.5LCAT, CETP, ABCA1, MTTP, LPL, APOB
9myocardial infarction30.5COG2, LCAT, APOA1, LDLR, CETP, HMGCR
10hepatitis30.5LDLR, EPHX2
11type 2 diabetes mellitus30.4COG2, PON2, MTTP, LPL, APOB, APOA2
12ischemic heart disease30.3COG2, APOA1, APOB, LPL, ABCA1, HMGCR
13hypothyroidism30.3LDLR, CETP, CYP7A1, APOB, COG2
14ischemia30.3HMGCR
15xanthomatosis30.2LDLR, LDLRAP1, ABCA1, CYP7A1, LPL, APOB
16acute myocardial infarction30.2LCAT, APOA1, APOB, HMGCR
17vascular disease30.1LCAT, APOA1, APOE, APOB, LPL, ABCA1
18hyperlipidemia type 330.1LDLR, CETP, HMGCR, LPL, APOB, APOE
19nephrotic syndrome30.1LCAT, APOA1, APOE, APOB, LPL, HMGCR
20familial hypertriglyceridemia30.0APOA1, APOE, APOA2, APOB, LPL
21coronary stenosis30.0APOA1, APOB, CETP
22sitosterolemia30.0CYP7A1, HMGCR
23alzheimer's disease29.9COG2, APOE, APOB, ITIH4, PON2, ABCA1
24arteriosclerosis29.9COG2, APOA1, APOB, LPL, HMGCR, LDLR
25essential hypertension29.9LCAT, APOA1, APOB, LPL, CETP
26fish-eye disease29.9APOA2, APOA1, LCAT
27glucose intolerance29.9APOB, MTTP, CYP7A1
28arthritis29.9HMGCR
29hypertriglyceridemia29.7CETP, HMGCR, ABCA1, CYP7A1, MTTP, LPL
30abetalipoproteinemia29.7PCSK9, MTTP, LPL, APOB, APOE, APOA1
31cerebrovascular disease29.7COG2, APOA1, APOE, APOB, LPL, HMGCR
32hyperglycemia29.7CETP, HMGCR, LPL, APOB, COG2
33diabetic nephropathy29.7APOA1, APOE, APOB, PON2, HMGCR
34dementia29.7APOE, LPL, ITIH4, CETP
35peripheral vascular disease29.7APOA1, APOB, HMGCR, CETP
36hepatitis c29.7LDLR, HMGCR, MTTP, LPL
37breast cancer29.7LCAT, EPHX2, ABCA1, LDLR
38arcus senilis29.7LCAT, APOA1, APOB
39cholestasis29.7CETP, CYP7A1, LCAT
40lung cancer29.7PCSK9
41alagille syndrome29.7LCAT, APOA1
42hyperhomocysteinemia29.7APOE
43cholelithiasis29.7CYP7A1
44psoriasis29.7LDLR
45cerebral atherosclerosis29.7APOA1
46cerebritis10.3
47supravalvular aortic stenosis10.2
48aortic atherosclerosis10.1
49cerebrotendinous xanthomatosis10.1
50obstructive jaundice10.0

Graphical network of the top 20 diseases related to Hypercholesterolemia:



Diseases related to hypercholesterolemia

Clinical Features for Hypercholesterolemia

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46OMIM
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Clinical features from OMIM:

143890

Drugs & Therapeutics for Hypercholesterolemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hypercholesterolemia

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Anatomical Context for Hypercholesterolemia

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32MalaCards
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MalaCards organs/tissues related to Hypercholesterolemia:

32
Heart

Animal Models for Hypercholesterolemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypercholesterolemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.4LPL, APOA2, APOE, APOA1, LCAT, MTTP
2MP:000537011.3LDLR, ABCA1, CYP7A1, PCSK9, MTTP, ITIH4
3MP:000538510.9LDLR, ABCA1, EPHX2, PON2, MTTP, LPL
4MP:000539510.8LDLR, ABCA1, APOA2, APOE

Publications for Hypercholesterolemia

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Genetic Variations for Hypercholesterolemia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Hypercholesterolemia:

62 (show all 91)
id Symbol AA change Variation ID SNP ID
1LDLRp.Arg78CysVAR_005307
2LDLRp.Trp87GlyVAR_005308
3LDLRp.Cys89TyrVAR_005309
4LDLRp.Asp90AsnVAR_005311
5LDLRp.Asp90TyrVAR_005312
6LDLRp.Gln92GluVAR_005313
7LDLRp.Cys95GlyVAR_005314
8LDLRp.Glu101LysVAR_005315
9LDLRp.Cys116ArgVAR_005317
10LDLRp.Glu140LysVAR_005318
11LDLRp.Cys160TyrVAR_005320
12LDLRp.Asp168HisVAR_005321
13LDLRp.Asp168AsnVAR_005322
14LDLRp.Asp168TyrVAR_005323
15LDLRp.Cys173TrpVAR_005325
16LDLRp.Asp175AsnVAR_005326
17LDLRp.Ser177LeuVAR_005327
18LDLRp.Cys197ArgVAR_005330
19LDLRp.Asp221GlyVAR_005332
20LDLRp.Asp221TyrVAR_005333
21LDLRp.Asp224ValVAR_005336
22LDLRp.Asp227GluVAR_005338
23LDLRp.Glu228LysVAR_005341
24LDLRp.Cys231GlyVAR_005342
25LDLRp.Cys248TyrVAR_005345
26LDLRp.Cys276TyrVAR_005349
27LDLRp.Glu277LysVAR_005350rs148698650
28LDLRp.Asp301AlaVAR_005352
29LDLRp.Cys302TyrVAR_005353
30LDLRp.Cys302TrpVAR_005354
31LDLRp.Cys313TyrVAR_005358
32LDLRp.Cys318PheVAR_005360
33LDLRp.His327TyrVAR_005361
34LDLRp.Cys329TyrVAR_005362
35LDLRp.Cys338SerVAR_005364
36LDLRp.Asp342AsnVAR_005366rs139361635
37LDLRp.Arg350ProVAR_005368
38LDLRp.Cys368ArgVAR_005374
39LDLRp.Ala399AspVAR_005376
40LDLRp.Leu414ArgVAR_005379
41LDLRp.Arg416GlnVAR_005380
42LDLRp.Arg416TrpVAR_005381
43LDLRp.Ile423ThrVAR_005382
44LDLRp.Val429MetVAR_005383rs28942078
45LDLRp.Ala431ThrVAR_005384rs28942079
46LDLRp.Asp433HisVAR_005385
47LDLRp.Asp482HisVAR_005391
48LDLRp.Trp483ArgVAR_005392
49LDLRp.Asn564HisVAR_005399rs28942086
50LDLRp.Asn564SerVAR_005400
51LDLRp.Asp579AsnVAR_005402
52LDLRp.Gly592GluVAR_005403
53LDLRp.Arg633CysVAR_005405
54LDLRp.Pro649LeuVAR_005406
55LDLRp.Cys667TyrVAR_005407rs28942083
56LDLRp.Cys677ArgVAR_005408
57LDLRp.Pro685LeuVAR_005410rs28942084
58LDLRp.Asp700GluVAR_005412
59LDLRp.Val797MetVAR_005415
60LDLRp.Tyr828CysVAR_005419rs28942085
61LDLRp.Ala50SerVAR_007979rs137853960
62LDLRp.Ser56ProVAR_007980
63LDLRp.Asp175TyrVAR_007981
64LDLRp.Asp221AsnVAR_007982
65LDLRp.Glu288LysVAR_007983
66LDLRp.Asp356TyrVAR_007984
67LDLRp.Gln366ArgVAR_007985
68LDLRp.Cys379TyrVAR_007986
69LDLRp.Leu401ValVAR_007987
70LDLRp.Leu432ValVAR_007988
71LDLRp.Pro608SerVAR_007989
72LDLRp.Phe403LeuVAR_008995
73LDLRp.Leu568ValVAR_008996
74LDLRp.Glu714LysVAR_008997
75LDLRp.Cys46SerVAR_013949
76LDLRp.Cys184TyrVAR_013951
77LDLRp.Cys261PheVAR_013953
78LDLRp.Cys134PheVAR_062371
79LDLRp.Cys134TrpVAR_062372
80LDLRp.Cys222TyrVAR_062373
81LDLRp.Gln254ProVAR_062374
82LDLRp.Cys276ArgVAR_062375
83LDLRp.Cys318ArgVAR_062376
84LDLRp.Cys358TyrVAR_062377
85LDLRp.Asn370ThrVAR_062378
86LDLRp.Asp415GlyVAR_062379
87LDLRp.Ile451ThrVAR_062380
88LDLRp.Leu479ProVAR_062381
89LDLRp.Asp579TyrVAR_062382
90LDLRp.Pro826SerVAR_062383
91LDLRp.Cys329PheVAR_067196

Expression for genes affiliated with Hypercholesterolemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypercholesterolemia

Search GEO for disease gene expression data for Hypercholesterolemia.

Pathways for genes affiliated with Hypercholesterolemia

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Hypercholesterolemia according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4LDLR, LCAT, APOA1, CETP, HMGCR, ABCA1
2
Hide members
11.2CETP, ABCA1, MTTP, LPL, APOB, APOA2
3
Hide members
11.2LCAT, APOA1, APOE, APOA2, APOB, LPL
4
Hide members
10.9APOA1, APOE, APOA2, APOB, LPL, LDLR
510.9APOA1, APOE, APOA2, APOB, LPL, LDLR
6
Hide members
10.9APOA1, APOA2, CYP7A1, ABCA1, HMGCR
710.8APOA1, APOB, ABCA1, LDLR
810.8ABCA1, APOB, APOA2, APOA1
910.8APOA1, APOB, MTTP, ABCA1
1010.8CYP7A1, LPL, APOA2, APOA1
1110.7APOB, CETP, LDLR
1210.7CYP7A1, HMGCR, LDLR
1310.7ABCA1, HMGCR, LDLR
14
Hide members
10.7LDLR, HMGCR, LPL
15
Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
10.7ABCA1, APOA2, APOA1
1610.7APOB, APOE, APOA1
17
Hide members
10.7APOA1, APOE, APOB
1810.6LDLRAP1, LDLR
1910.6APOA1, APOB
2010.6CETP, ABCA1

Compounds for genes affiliated with Hypercholesterolemia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Hypercholesterolemia according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1cholesterol44 28 11 2415.1COG2, LCAT, APOA1, APOE, APOA2, APOB
2lipid4412.0APOB, LPL, MTTP, PON2, PCSK9, CYP7A1
3cholesterol ester4411.9LDLR, CETP, HMGCR, COG2, LCAT, APOA1
4sterol4411.8COG2, LCAT, APOA1, APOE, APOB, MTTP
5atorvastatin44 49 28 11 2415.8COG2, LCAT, APOA1, APOE, APOB, LPL
6bezafibrate44 28 1113.8APOA2, APOB, LPL, CYP7A1, ABCA1, HMGCR
7phospholipid4411.8CETP, APOA1, COG2, APOE, LPL, MTTP
8simvastatin44 49 59 28 11 2416.7LDLR, CETP, COG2, LCAT, APOA1, APOE
9phosphatidylcholine4411.7ABCA1, LDLR, CYP7A1, MTTP, CETP, LCAT
10pravastatin44 49 28 11 2415.7LCAT, APOA1, APOE, APOB, CYP7A1, ABCA1
11fenofibrate44 49 1113.7COG2, APOA1, APOA2, APOB, LPL, EPHX2
12triacylglycerol4411.7COG2, LCAT, APOA1, APOE, APOA2, APOB
13probucol44 1112.6LCAT, APOA1, APOE, APOB, LPL, ABCA1
14gemfibrozil44 28 1113.6COG2, APOA1, APOE, APOB, LPL, HMGCR
15niacin44 1112.6COG2, APOA1, APOB, LPL, MTTP, ABCA1
16heparin44 28 11 2414.6COG2, APOE, APOA2, HMGCR, ITIH4, LPL
17testosterone44 59 11 2414.5ABCA1, CETP, COG2, LCAT, APOE, APOB
18fluvastatin44 49 28 1114.5HMGCR, CETP, LDLR, LPL, APOB, COG2
19ezetimibe44 1112.5COG2, APOA1, APOB, MTTP, ABCA1, HMGCR
20lovastatin44 49 59 28 1115.4HMGCR, LPL, COG2, CETP, APOB, APOE
21glutamine4411.4APOA2, LCAT, APOE, APOB, LDLR, ITIH4
22thyroxine44 2412.4COG2, APOA1, APOE, APOB, LPL, HMGCR
23intralipid4411.4LCAT, APOA1, APOE, APOA2, APOB, LPL
24lathosterol44 2412.4APOE, APOB, MTTP, CYP7A1, HMGCR, CETP
25fatty acid4411.4LDLR, CETP, ABCA1, LPL, APOB, APOA2
26cholestyramine4411.4COG2, APOE, APOB, CYP7A1, HMGCR, CETP
27aspirin44 49 28 2414.4LDLR, HMGCR, ABCA1, APOB, APOE, COG2
28oleic acid44 28 11 2414.4CYP7A1, ABCA1, CETP, LDLR, MTTP, LPL
29ciprofibrate44 2812.3APOB, LDLR, HMGCR, EPHX2, LPL, APOA1
30retinyl palmitate44 2412.3LCAT, APOE, LPL, APOB, COG2, APOA1
31rosuvastatin44 49 28 1114.3LDLR, HMGCR, APOB, COG2, CETP, APOA1
32psyllium4411.2CETP, LDLR, LCAT, APOB, HMGCR
33dextran sulfate4411.2APOA1, LPL, LDLR, CETP, ITIH4, APOB
34estrogen4411.2CETP, CYP7A1, COG2, LCAT, MTTP
35dimyristoylphosphatidylcholine4411.2APOA1, LCAT, APOE, APOA2, LDLR
36palmitate4411.1CETP, COG2, LCAT, LDLR
37vitamin a44 11 2413.1APOA1, CETP, LDLR, LPL, APOB, APOE
38alpha tocopherol4411.1LCAT, LPL, LDLR
39colestipol4411.1HMGCR, COG2, APOA1, APOB
40cyclosporin a44 28 5913.1COG2, APOE, LPL, ITIH4, LDLR, HMGCR
41serine4411.1LCAT, APOA2, LDLR, CETP, PCSK9, HMGCR
42tocopherol4411.1APOB, HMGCR, LDLR, LPL, APOA1
433-hydroxy-3-methylglutaryl-coa44 2412.0MTTP, LDLR, HMGCR, ABCA1, CYP7A1
44sitosterol4411.0CYP7A1, HMGCR, APOB, APOE
4524s-hydroxy-cholesterol4411.0ABCA1, CYP7A1, APOE, HMGCR
46xbai4411.0LPL, APOE, LDLR
47linoleic acid44 28 2412.9LDLR, CETP, ABCA1, MTTP, LPL, LCAT
48campesterol44 2411.9APOB, APOA1, HMGCR, APOE
49mspi4410.8LDLR, APOB, APOA2, APOA1, CETP
50taurocholate4410.6HMGCR, CYP7A1, LPL, APOB, APOA1

GO Terms for genes affiliated with Hypercholesterolemia

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16Gene Ontology
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Cellular components related to Hypercholesterolemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3APOE, APOA2, APOB, LPL, ITIH4, PON2
2early endosomeGO:00576911.3APOE, APOA2, APOB, PCSK9, LDLRAP1, LDLR
3extracellular spaceGO:00561511.2PCSK9, LPL, CETP, APOE, APOA1, LCAT
4very-low-density lipoprotein particleGO:03436111.1LPL, APOA1, APOE, APOA2, APOB
5high-density lipoprotein particleGO:03436411.1LCAT, APOA1, APOE, APOA2, CETP
6chylomicronGO:04262711.0APOE, APOA2, APOB, LPL
7Golgi apparatusGO:00579411.0APOE, MTTP, PCSK9, EPHX2, ABCA1, LDLR
8low-density lipoprotein particleGO:03436210.9APOE, LDLR, APOB
9endocytic vesicle lumenGO:07168210.9APOE, APOB, APOA1
10endoplasmic reticulum lumenGO:00578810.8APOA2, APOA1, MTTP, APOB
11intermediate-density lipoprotein particleGO:03436310.7APOB, APOE
12late endosomeGO:00577010.7APOE, LDLR, PCSK9
13extrinsic to external side of plasma membraneGO:03123210.5PCSK9, APOE
14spherical high-density lipoprotein particleGO:03436610.3APOA1, APOA2

Biological processes related to Hypercholesterolemia according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1cholesterol homeostasisGO:04263211.9CETP, PCSK9, MTTP, APOB, APOE, APOA1
2small molecule metabolic processGO:04428111.9CYP7A1, LCAT, APOA1, APOE, APOA2, APOB
3lipoprotein metabolic processGO:04215711.7PCSK9, APOA2, APOB, LPL, MTTP, APOA1
4cholesterol metabolic processGO:00820311.7LDLR, APOA1, CETP, ABCA1, LCAT, APOE
5reverse cholesterol transportGO:04369111.4ABCA1, APOE, APOA2, APOA1, CETP, LCAT
6triglyceride metabolic processGO:00664111.4CETP, APOE, APOA2, LPL, MTTP, PCSK9
7retinoid metabolic processGO:00152311.3APOA1, LPL, APOE, APOA2, LDLR, APOB
8phototransduction, visible lightGO:00760311.3LPL, LDLR, APOA1, APOE, APOA2, APOB
9cholesterol transportGO:03030111.3LCAT, LDLR, APOA1, APOB, CETP
10high-density lipoprotein particle remodelingGO:03437511.3CETP, APOA2, APOE, APOA1, LCAT
11cholesterol effluxGO:03334411.3APOA1, APOE, APOA2, APOB, ABCA1
12receptor-mediated endocytosisGO:00689811.2APOB, LDLR, LDLRAP1, APOE, CETP
13cellular lipid metabolic processGO:04425511.2ABCA1, APOA1, HMGCR, APOA2, CYP7A1
14lipoprotein biosynthetic processGO:04215811.2LCAT, APOA1, APOE, APOB
15high-density lipoprotein particle assemblyGO:03438011.2ABCA1, APOA2, APOE, APOA1
16very-low-density lipoprotein particle remodelingGO:03437211.2APOE, CETP, LPL, LCAT
17phospholipid effluxGO:03370011.2ABCA1, APOA2, APOE, APOA1
18low-density lipoprotein particle remodelingGO:03437411.2CETP, APOB, APOE, APOA2
19lipoprotein catabolic processGO:04215911.1APOB, LDLR, APOE
20regulation of Cdc42 protein signal transductionGO:03248911.1APOA1, APOE, ABCA1
21high-density lipoprotein particle clearanceGO:03438411.1APOA1, APOA2, APOE
22positive regulation of cholesterol esterificationGO:01087311.1APOE, APOA2, APOA1
23phospholipid homeostasisGO:05509111.1ABCA1, APOA1, CETP
24triglyceride homeostasisGO:07032811.0CETP, APOA1, LPL
25phosphatidylcholine biosynthetic processGO:00665611.0LCAT, APOA1, APOA2
26negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.9APOA1, APOA2
27negative regulation of lipase activityGO:06019210.9APOA1, APOA2
28cholesterol importGO:07050810.9LDLR, APOA1
29regulation of intestinal cholesterol absorptionGO:03030010.9APOA2, APOA1
30protein oxidationGO:01815810.9APOA1, APOA2
31peripheral nervous system axon regenerationGO:01401210.9APOA1, APOE
32negative regulation of cytokine secretion involved in immune responseGO:00274010.9APOA2, APOA1
33protein lipidationGO:00649710.9ABCA1, MTTP
34peptidyl-methionine modificationGO:01820610.8APOA1, APOA2
35positive regulation of cholesterol storageGO:01088610.8LPL, APOB
36phospholipid transportGO:01591410.8LDLR, CETP
37low-density lipoprotein particle clearanceGO:03438310.8LDLR, APOB
38cellular response to cholesterolGO:07139710.7CYP7A1, APOE
39cholesterol catabolic processGO:00670710.7CYP7A1, APOE
40positive regulation of cholesterol effluxGO:01087510.6APOE, ABCA1
41positive regulation of macrophage derived foam cell differentiationGO:01074410.6APOB, LPL
42negative regulation of macrophage derived foam cell differentiationGO:01074510.5ABCA1, CETP
43lipoprotein transportGO:04295310.3MTTP, APOB

Molecular functions related to Hypercholesterolemia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.5APOA2, APOE, APOA1, LCAT, COG2, APOB
2cholesterol transporter activityGO:01712711.3CETP, ABCA1, APOB, APOA2, APOE, APOA1
3low-density lipoprotein particle receptor bindingGO:05075011.1APOE, APOB, PCSK9, LDLRAP1
4apolipoprotein bindingGO:03418511.1LPL, MTTP, PCSK9, ABCA1
5lipid transporter activityGO:00531911.1APOE, APOA2, MTTP, CETP
6cholesterol bindingGO:01548511.1CETP, ABCA1, APOA2, APOA1
7phospholipid bindingGO:00554311.1APOA1, APOE, APOA2, APOB, ABCA1
8lipid bindingGO:00828911.0APOE, APOA2, MTTP, CETP
9apolipoprotein receptor bindingGO:03419011.0APOA1, APOA2, PCSK9
10phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022811.0APOA2, APOE, APOA1
11phospholipid transporter activityGO:00554811.0APOA1, ABCA1, CETP
12beta-amyloid bindingGO:00154011.0LDLRAP1, APOE, APOA1
13triglyceride bindingGO:01712910.8CETP, LPL
14high-density lipoprotein particle receptor bindingGO:07065310.8APOA1, APOA2
15apolipoprotein A-I bindingGO:03418610.8LCAT, ABCA1
16very-low-density lipoprotein particle receptor bindingGO:07032610.7PCSK9, APOE
17lipase inhibitor activityGO:05510210.7APOA2, APOA1
18low-density lipoprotein particle bindingGO:03016910.6LDLR, PCSK9
19high-density lipoprotein particle bindingGO:00803510.5APOA1, APOA2
20phosphatidylcholine bindingGO:03121010.3CETP, APOA2

Products for genes affiliated with Hypercholesterolemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypercholesterolemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet