HES
MCID: HYP098
MIFTS: 61

Hypereosinophilic Syndrome (HES) malady

Blood, Cancer categories

Summaries for Hypereosinophilic Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hypereosinophilic syndrome is a group of rare blood disorders characterized by increased levels of eosinophils (a type of white blood cell that plays a role in the human immune system) persisting for more than six months. the signs and symptoms are due to involvement of several internal organs and there is usually no evidence of parasites, allergy, or other known causes of an elevated eosinophil count. this condition largely occurs in males, typically at middle age. it usually presents with fever, weight loss, fatigue, and rash. an enlarged liver and spleen and liver is often present. the lungs, kidneys, heart, and nervous system can also be affected. last updated: 7/11/2011

MalaCards: Hypereosinophilic Syndrome, also known as hypereosinophilic syndrome, idiopathic, is related to endomyocardial fibrosis and eosinophilic gastroenteritis. An important gene associated with Hypereosinophilic Syndrome is PDGFRA (platelet-derived growth factor receptor, alpha polypeptide), and among its related pathways are Osteoblast Signaling and Alzheimers Disease Pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are renal/urinary system and respiratory system.

Wikipedia:64 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

Aliases & Classifications for Hypereosinophilic Syndrome

Sources:
43NIH Rare Diseases, 20GeneTests, 45Novoseek, 49Orphanet, 39NCBI Bookshelf, 22GTR, 61UMLS, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
hypereosinophilic syndrome:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

hypereosinophilic syndrome 43 20 45 49
hypereosinophilic syndrome, idiopathic 43 22
idiopathic hypereosinophilic syndrome 45 61
hes 43 39
chronic eosinophilic leukemia 61


External Ids:

UMLS via Orphanet62 C1540912
MESH via Orphanet36 D017681
ICD10 via Orphanet26 D47.5
SNOMED-CT via Orphanet58 128835008

Related Diseases for Hypereosinophilic Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hypereosinophilic Syndrome family:

primary hypereosinophilic syndrome

Diseases related to Hypereosinophilic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 313)
idRelated DiseaseScoreTop Affiliating Genes
1endomyocardial fibrosis30.7PDGFRA, FIP1L1
2eosinophilic gastroenteritis30.5IL5, IGHE, CCL11
3acute leukemia30.5WT1, CSF2, FGFR1, IL3, KIT
4vasculitis30.4PRG2
5asthma30.4IL5, RNASE3, EPX, IGHE
6churg-strauss syndrome30.4IL5, RNASE3
7mastocytosis30.4PDGFRB, PDGFRA, IGHE, FIP1L1, CD69, IL2RA
8systemic mastocytosis30.3KIT, PDGFRB, IL2RA, FGFR1, PDGFRA
9ulcerative colitis30.3IL2RA, RNASE3, EPX, CCL11
10myeloproliferative disorder30.3FGFR1, KIT, IL3, PDGFRB, CSF2, PDGFRA
11hepatitis c30.1IFNA1
12arthritis30.1C5AR1, PLA2G4A, CD69, CSF2
13systemic lupus erythematosus30.1C5AR1, IL2RA, CD69, IFNA1
14eosinophilic esophagitis29.9IL5, CCL11
15anaplastic large cell lymphoma29.9TNFSF8, IL2RA
16uveitis29.9CCL11, IL2RA, CD69
17helminthiasis29.9IGHE, RNASE3, IL5
18mycosis fungoides29.9IFNA1, IL5, IL2RA
19cyclic hematopoiesis29.9CSF2, IL3
20kimura disease29.9RNASE3, PRG2, IGHE, IL5
21adenocarcinoma29.9WT1, PLA2G4A, FGFR1, PDGFRB
22urticaria29.9PRG2, IGHE, RNASE3, C5AR1
23bullous pemphigoid29.9IL5, PRG2, CCL11, IGHE, RNASE3
24thrombocytopenia29.9IL3, CSF2, IFNA1
25chronic myeloid leukemia29.9FGFR1, KIT, PDGFRA, IL3, CSF2, WT1
26bronchitis29.8RNASE3
27acute pancreatitis29.8FGFR1
28n syndrome10.7
29pdgfrb-associated chronic eosinophilic leukemia10.7
30pdgfra-associated chronic eosinophilic leukemia10.6
31secondary hypereosinophilic syndrome10.5
32loeffler endocarditis10.4
33loeffler syndrome10.4
34mass syndrome10.4
35mast syndrome10.4
36primary hypereosinophilic syndrome10.4
37char syndrome10.4
38micro syndrome10.3
39lymphomatoid papulosis10.3
40hypereosinophilic syndrome, idiopathic, resistant to imatinib10.3
41coronary aneurysm10.2
42adult syndrome10.2
43acute myocardial infarction10.2
44cutaneous necrotizing vasculitis10.2
45young syndrome10.2
46wells syndrome10.2
47mini stroke10.1
48autoimmune hemolytic anemia10.1
49leukemia, b-cell, chronic10.1
50leukemia, t-cell, chronic10.1

Graphical network of the top 20 diseases related to Hypereosinophilic Syndrome:



Diseases related to hypereosinophilic syndrome

Clinical Features for Hypereosinophilic Syndrome

Drugs & Therapeutics for Hypereosinophilic Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypereosinophilic Syndrome

Drug clinical trials:

Search ClinicalTrials for Hypereosinophilic Syndrome

Search NIH Clinical Center for Hypereosinophilic Syndrome

Search CenterWatch for Hypereosinophilic Syndrome

Genetic Tests for Hypereosinophilic Syndrome

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Hypereosinophilic Syndrome:

id Genetic test Affiliating Genes
1 Hypereosinophilic Syndrome20 PDGFRA
2 Idiopathic Hypereosinophilic Syndrome22

Anatomical Context for Hypereosinophilic Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hypereosinophilic Syndrome:

33
Skin, Liver, Brain, Kidney, Lung, Spleen, Bone marrow, Thymus, Heart, Myeloid, Nk cells, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Hypereosinophilic Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hypereosinophilic Syndrome

Sources:
51PubMed
See all sources

Articles related to Hypereosinophilic Syndrome:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Can ANCA differentiate eosinophilic granulomatosis with polyangiitis (Churg-Strauss) from idiopathic hypereosinophilic syndrome? (24144017)
2013
2
Erythrodermic mycosis fungoides with hypereosinophilic syndrome: a rare presentation. (23940492)
2013
3
Idiopathic hypereosinophilic syndrome in children: 3 cases with review of literature. (22740191)
2013
4
Idiopathic hypereosinophilic syndrome presenting as severe Loeffler's endocarditis. (23681213)
2013
5
Bioprosthetic valve replacement in idiopathic hypereosinophilic syndrome with mitral valve involvement. (24001347)
2013
6
Endomyocardial fibrosis in the context of hypereosinophilic syndrome: the contribution of cardiac MRI. (22819397)
2012
7
Hypereosinophilic syndrome, Churg-Strauss syndrome and parasitic diseases: possible links between eosinophilia and thrombosis. (22272911)
2012
8
Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. (21963210)
2011
9
Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) in a patient with hypereosinophilic syndrome showing multiple nodules on chest computed tomography. (22001479)
2011
10
Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings. (21628939)
2011
11
Steroid-unresponsive hypereosinophilic syndrome. (21781426)
2011
12
Suspected "t-cell-mediated" hypereosinophilic syndrome presenting with cerebral watershed infarcts. (22937347)
2011
13
Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome. (20810155)
2010
14
Impressive combination of multiple sinus valsalvae and coronary aneurysms due to hypereosinophilic syndrome. (20971227)
2010
15
Multiple bilateral cerebral infarcts in a patient with idiopathic hypereosinophilic syndrome. (21045519)
2010
16
Persistent cough: an unusual cause. Idiopathic hypereosinophilic syndrome (HES). (20965936)
2010
17
Membranous glomerulopathy associated with idiopathic hypereosinophilic syndrome. (20228521)
2010
18
Successful treatment of refractory idiopathic hypereosinophilic syndrome with etoposide. (19142161)
2009
19
The hypereosinophilic syndromes: current concepts and treatments. (19243381)
2009
20
Uncommon presentation of hypereosinophilic syndrome. (19999792)
2009
21
T-cell abnormalities are present at high frequencies in patients with hypereosinophilic syndrome. (19734416)
2009
22
Hypereosinophilic syndrome causing acute hemiplegia in childhood. (18760055)
2008
23
Platelet-derived growth factor receptor-alpha-associated hypereosinophilic syndrome and lymphomatoid papulosis. (16965435)
2006
24
Idiopathic hypereosinophilic syndrome: toward a new molecular-targeted therapy and a new cytomorphological and molecular definition]. (15951264)
2005
25
Images in cardiology: Hypereosinophilic syndrome and effect of imatinib mesylate. (15869052)
2005
26
Pediatric hypereosinophilic syndrome (HES) clinically differs from adult HES, but there is a lack of confirmatory laboratory data. (16356454)
2005
27
Defective CD3gamma gene transcription is associated with NFATc2 overexpression in the lymphocytic variant of hypereosinophilic syndrome. (16219537)
2005
28
Chronic hepatitis in hypereosinophilic syndrome: report of an unusual case. (16397421)
2005
29
Hypereosinophilic syndrome associated with acute necrotizing myocarditis and cardiomyopathy. (16258779)
2005
30
Rapid reversion of Loeffler's endocarditis by imatinib in early stage clonal hypereosinophilic syndrome. (15621768)
2004
31
A rare case of idiopathic hypereosinophilic syndrome involving the oral cavity associated with the esophagus and gastrointestinal tract. (15168780)
2004
32
Mucosal ulcerations revealing primitive hypereosinophilic syndrome. (12695143)
2003
33
Dermal endothelial cells express eotaxin in hypereosinophilic syndrome. (14576680)
2003
34
The idiopathic hypereosinophilic syndrome. (14763243)
2003
35
Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome. (12595304)
2003
36
Unusual cardiac manifestation of hypereosinophilic syndrome. (12185226)
2002
37
A case of hypereosinophilic syndrome presenting mid-ventricular obstruction. (12027235)
2002
38
Hypereosinophilic dermatosis: skin lesions as the only manifestation of the idiopathic hypereosinophilic syndrome? (10971369)
2000
39
Indolent course of a patient with hypereosinophilic syndrome associated with clonal T-cell proliferation. (10569307)
1999
40
Interferon-alpha in the idiopathic hypereosinophilic syndrome: consideration of five cases. (9829847)
1998
41
Acute aortic thrombosis despite anticoagulant therapy in idiopathic hypereosinophilic syndrome. (9849524)
1998
42
A case of hypereosinophilic syndrome associated with factor V Leiden mutation and thrombosis. (9576204)
1998
43
Study of release of eosinophil cationic proteins (ECP and EPX) in the hypereosinophilic syndrome (HES) and other hypereosinophilic conditions. (9785914)
1998
44
Treatment of hypereosinophilic syndrome in a child using cyclosporine: implication for a primary T-cell abnormality. (9093318)
1997
45
Clonal eosinophilic disorders and the hypereosinophilic syndrome. (9370044)
1997
46
Further evidence for the clonal nature of the idiopathic hypereosinophilic syndrome: complete haematological and cytogenetic remission induced by interferon-alpha in a case with a unique chromosomal abnormality. (8562393)
1996
47
Long-term outcome of idiopathic hypereosinophilic syndrome--transition to eosinophilic gastroenteritis and clonal expansion of T-cells. (8723426)
1996
48
Hypereosinophilic syndrome. (7640191)
1995
49
Crescentic glomerulonephritis and eosinophilic interstitial infiltrates in a patient with hypereosinophilic syndrome. (7746781)
1995
50
Hypereosinophilic syndrome evolving to acute lymphoblastic leukemia. (1747458)
1991

Genetic Variations for Hypereosinophilic Syndrome

Expression for genes affiliated with Hypereosinophilic Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypereosinophilic Syndrome

Search GEO for disease gene expression data for Hypereosinophilic Syndrome.

Pathways for genes affiliated with Hypereosinophilic Syndrome

Sources:
38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 54Reactome, 50PharmGKB, 30KEGG, 60Tocris Bioscience
See all sources

Pathways related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PDGFRB, PDGFRA
210.1FGFR1, PDGFRA, PDGFRB
310.1FGFR1, PDGFRA, PDGFRB
410.1PDGFRB, PDGFRA, FGFR1
5
Hide members
10.1IL5, IL2RA, CCL11
610.1CCL11, IL5, C5AR1
710.1CCL11, IGHE, IL5
810.0IFNA1, IL3, IL5
9
Hide members
10.0KIT, FGFR1, PDGFRA, PDGFRB
10
Hide members
10.0PDGFRB, PDGFRA, FGFR1, KIT
11
Hide members
10.0PDGFRB, PDGFRA, FGFR1, KIT
12
Hide members
10.0KIT, FGFR1, PDGFRA, PDGFRB
1310.0PDGFRB, PDGFRA, CSF2, IL2RA
14
Hide members
10.0PLA2G4A, FGFR1, PDGFRA, PDGFRB
15
Hide members
9.9CSF2, IL2RA, IL3, IL5
16
Hide members
9.9IL5, IL3, IL2RA, CSF2
17
Hide members
9.9PDGFRB, PDGFRA, FGFR1, IL2RA, IL5
189.9PDGFRB, PDGFRA, FGFR1, IL2RA, KIT
19
Hide members
9.9PDGFRB, PDGFRA, FGFR1, IL3, KIT
20
Hide members
9.8PDGFRB, PDGFRA, IGHE, FGFR1, KIT
219.8CSF2, IL2RA, IL3, IL5, KIT
229.8PDGFRA, WT1, FGFR1, IL3, PLA2G4A
23
Hide members
9.8IL5, IL3, IL2RA, CSF2, IFNA1
249.8IFNA1, CSF2, IL2RA, IL3, IL5
25
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL2RA, PLA2G4A, KIT
26
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL2RA, IL3, KIT
27
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL2RA, IL3, KIT
28
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL2RA, IL3, KIT
29
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL3, PLA2G4A, KIT
30
Hide members
9.6PDGFRB, PDGFRA, CSF2, TNFSF8, PRG2, FGFR1
319.5IFNA1, PDGFRB, PDGFRA, FGFR1, IL2RA, IL3
32
Hide members
9.5PDGFRB, PDGFRA, PRG2, FGFR1, IL2RA, IL3
33
Hide members
9.4CCL11, IFNA1, CSF2, IGHE, IL3, IL5
34
Hide members
9.4CCL11, IFNA1, PRG2, EPX, RNASE3, IL2RA
35
Hide members
9.2CCL11, PDGFRB, PDGFRA, CSF2, TNFSF8, FGFR1
36
Hide members
9.2IFNA1, PDGFRB, PDGFRA, CSF2, IGHE, FGFR1
37
Hide members
9.1CSF2, PDGFRA, PDGFRB, CCL11, TNFSF8, FGFR1
38
Hide members
8.9KIT, CCL11, IFNA1, PDGFRB, PDGFRA, CSF2

Compounds for genes affiliated with Hypereosinophilic Syndrome

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 195)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7RNASE3
2cycloheximide4510.6IFNA1
3pge24510.4EPX, CSF2, CCL11
4unicap4510.2IGHE, CCL11, RNASE3, IL5
5sodium cromoglycate4510.2CCL11, IL5, RNASE3, EPX, IGHE
6lte44510.2CCL11, RNASE3, EPX, IL5
7ketotifen45 1111.2CCL11, RNASE3, IL5, IGHE, EPX
8salmeterol45 50 29 1113.1EPX, RNASE3, CSF2, CCL11, IL5, PLA2G4A
9cetirizine45 29 11 2413.1RNASE3, IL5, CCL11, CSF2, EPX, IGHE
10montelukast45 50 29 1113.1IGHE, IL5, RNASE3, IL2RA, CCL11
11budesonide45 50 1112.1EPX, CSF2, CCL11, RNASE3, IL5, IGHE
12ag-12964510.1IL3, KIT, PDGFRA, PDGFRB
13nedocromil sodium4510.1IL5, IL3, RNASE3, IGHE
14salbutamol45 50 29 11 2414.0EPX, IL5, RNASE3, IGHE, CCL11
15fluticasone propionate45 50 60 1113.0IL5, PLA2G4A, RNASE3, IGHE, CSF2, CCL11
16n-formylmethionyl-leucylphenylalanine4510.0C5AR1, IL5, IL3, RNASE3, CSF2, CCL11
17methacholine45 1111.0RNASE3, IGHE, PRG2, CSF2, CCL11, IL5
18anaphylatoxin4510.0RNASE3, PLA2G4A, IL3, C5AR1, CSF2
19poly(i-c)4510.0CSF2, CCL11, IL5, IL3, CD69, IFNA1
20allergens459.9RNASE3, CD69, CCL11, PRG2, IL5, EPX
21dexamethasone45 50 29 1112.9RNASE3, EPX, IGHE, IL3, IFNA1, CCL11
22cytochalasin b459.9RNASE3, C5AR1, EPX, CSF2, PRG2
23leukotriene b445 60 2411.8CSF2, IL3, RNASE3, CCL11, C5AR1, PLA2G4A
24herbimycin a45 6010.8CSF2, PLA2G4A, IL5, IL3, IL2RA, CD69
25calcitriol45 60 11 2412.8PLA2G4A, IL3, WT1, CSF2, PDGFRA, PDGFRB
26rantes459.8IFNA1, C5AR1, IL3, IL2RA, CCL11, RNASE3
27vincristine45 50 1111.8IFNA1, IL3, KIT, WT1, CSF2, IL2RA
28pgd2459.8IGHE, PLA2G4A, C5AR1, IL5, CCL11, PRG2
29heparin45 29 11 2412.8CCL11, CSF2, C5AR1, IL2RA, RNASE3, EPX
30ionomycin459.8CCL11, CSF2, IL5, CD69, IL2RA, IL3
31imatinib45 50 1111.8FGFR1, IFNA1, IL3, PDGFRB, PDGFRA, WT1
32prednisolone45 29 1111.8CCL11, EPX, RNASE3, IL2RA, IGHE, IL5
33h2o2459.7C5AR1, PDGFRB, CSF2, EPX, FGFR1, IL3
34ivig459.7IL3, CSF2, IGHE
35ltc4459.7C5AR1, PLA2G4A, IL5, RNASE3, EPX, PRG2
36vitamin d459.6C5AR1, PLA2G4A, IL5, PDGFRB, IL3, IGHE
37fmlp459.5CCL11, IL5, PLA2G4A, C5AR1, CSF2, PRG2
38genistein45 29 60 2 11 2414.5CCL11, CSF2, PDGFRB, PRG2, CD69, FGFR1
39creatinine459.5RNASE3, EPX, CD69, IGHE, WT1, C5AR1
40actinomycin d459.5CCL11, KIT, PLA2G4A, IL3, CD69, PRG2
41cyclosporin a45 29 6011.4CCL11, IL5, IL3, IL2RA, RNASE3, CD69
42polysaccharide459.4CSF2, IGHE, IL3, CD69, FGFR1, RNASE3
43thymidine45 2410.4CD69, FGFR1, CCL11, IFNA1, PDGFRA, CSF2
44phosphatidylinositol459.3CCL11, PDGFRA, CSF2, CD69, FGFR1, C5AR1
45nitric oxide45 11 2411.2WT1, CD69, CCL11, EPX, FGFR1, RNASE3
46cysteine459.2PDGFRB, IL2RA, FGFR1, EPX, PRG2, WT1
47retinoic acid45 2410.1CSF2, WT1, PRG2, IGHE, FGFR1, RNASE3
48histamine45 29 2411.1CCL11, CSF2, PRG2, IGHE, EPX, FGFR1
49vegf459.0RNASE3, FGFR1, IGHE, WT1, CSF2, PDGFRA
50tyrosine458.5C5AR1, IFNA1, CCL11, PDGFRA, CSF2, KIT

GO Terms for genes affiliated with Hypereosinophilic Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to plasma membraneGO:03122610.2PDGFRA, PDGFRB
2extracellular spaceGO:0056159.7KIT, IL5, IL3, TNFSF8, CSF2, CCL11
3external side of plasma membraneGO:0098979.7PDGFRA, CD69, IL2RA, KIT
4extracellular regionGO:0055769.3IL5, CCL11, CSF2, PRG2, IGHE, FGFR1

Biological processes related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.6PDGFRA, PDGFRB
2metanephric glomerular capillary formationGO:07227710.6PDGFRB, PDGFRA
3cell chemotaxisGO:06032610.5PDGFRA, PDGFRB, KIT
4mast cell chemotaxisGO:00255110.5CCL11, KIT
5positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.5PDGFRB, PDGFRA, KIT
6adrenal gland developmentGO:03032510.5PDGFRB, WT1, PDGFRA
7metanephric S-shaped body morphogenesisGO:07228410.5WT1, PDGFRB
8retina vasculature development in camera-type eyeGO:06129810.4PDGFRB, PDGFRA
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4KIT, IL3, CSF2
10positive regulation of podosome assemblyGO:07180310.4CSF2, IL5
11positive regulation of phospholipase C activityGO:01086310.4KIT, PDGFRB, PDGFRA, FGFR1
12positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.4KIT, FGFR1, PDGFRA, PDGFRB
13peptidyl-tyrosine phosphorylationGO:01810810.4KIT, PDGFRB, PDGFRA, FGFR1
14positive regulation of DNA replicationGO:04574010.4PDGFRA, CSF2, IL3
15metanephric mesenchyme developmentGO:07207510.3WT1, PDGFRB
16cardiac myofibril assemblyGO:05500310.3PDGFRA, PDGFRB
17phosphatidylinositol-mediated signalingGO:04801510.3PDGFRA, PDGFRB, FGFR1, KIT
18protein autophosphorylationGO:04677710.3KIT, FGFR1, PDGFRA, PDGFRB
19fibroblast growth factor receptor signaling pathwayGO:00854310.3PDGFRB, PDGFRA, FGFR1, KIT
20epidermal growth factor receptor signaling pathwayGO:00717310.2FGFR1, PDGFRA, PDGFRB, KIT
21Fc-epsilon receptor signaling pathwayGO:03809510.2KIT, FGFR1, PDGFRB, PDGFRA, IGHE
22positive regulation of cell proliferationGO:00828410.1CSF2, FGFR1, PDGFRB, PDGFRA, KIT, IL3
23neurotrophin TRK receptor signaling pathwayGO:04801110.0PDGFRB, KIT, FGFR1, PDGFRA
24positive regulation of ERK1 and ERK2 cascadeGO:07037410.0PDGFRB, PDGFRA, C5AR1
25inflammatory responseGO:00695410.0C5AR1, KIT, IL5, CCL11
26positive regulation of JAK-STAT cascadeGO:04642710.0KIT, IL5
27immune responseGO:0069559.5PRG2, CSF2, IGHE, IL2RA, IL3, IL5

Molecular functions related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.3PDGFRA, PDGFRB
2protein tyrosine kinase activityGO:00471310.1KIT, FGFR1, PDGFRB
3platelet-derived growth factor bindingGO:04840710.0PDGFRA, PDGFRB
4cytokine activityGO:0051259.8CSF2, TNFSF8, IL3, IL5

Products for genes affiliated with Hypereosinophilic Syndrome

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Sources for Hypereosinophilic Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet