Hypereosinophilic Syndrome malady

NIH Rare Diseases: Hypereosinophilic syndrome is a group of rare blood disorders characterized by increased levels of eosinophils (a type of white blood cell that plays a role in the human immune system) persisting for more than six months. The signs and symptoms are due to involvement of several internal organs and there is usually no evidence of parasites, allergy, or other known causes of an elevated eosinophil count. This condition largely occurs in males, typically at middle age. It usually presents with fever, weight loss, fatigue, and rash. An enlarged liver and spleen and liver is often present. The lungs, kidneys, heart, and nervous system can also be affected.³⁰

MalaCards: Hypereosinophilic Syndrome, also known as HES, is related to asthma and ascariasis. An important gene associated with Hypereosinophilic Syndrome is PDGFRA (platelet-derived growth factor receptor, alpha polypeptide), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Asthma. The compounds aspartate and budesonide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and heart, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil...⁴⁴ more...

hypereosinophilic syndrome 7 30 16 32 hes 30 26 hypereosinophilic syndrome, idiopathic 30

idiopathic hypereosinophilic syndrome 32 chronic eosinophilic leukemia 43

Diseases related to hypereosinophilic syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 639)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	29.6	IL13, IL5, IGES, IGHE, RNASE3, EPX
2	ascariasis	28.5	IL5, IGHE, RNASE3
3	carcinoid tumors	28.3	IFNA1, IFNA2, PDGFRA, PDGFRB, TGFA
4	chronic myeloproliferative disease	28.3	JAK2, IL2, IL2RA, F5, PDGFRA, PDGFRB
5	duodenitis	28.2	KIT, IL5, IGHE, RNASE3, TGFA, CSF2
6	eosinophilic gastroenteritis	28.2	IL5, CCL11, IGES, IGHE, SRF, RNASE3
7	leukemia/lymphoma, t-cell	27.6	IL2, IL2RA, TNFSF8, WT1, ABL1
8	cervical carcinoma	27.5	KIT, JUN, IL2, IL2RA, IFNA1, IFNA2
9	hepatitis c	27.5	JUN, CD69, IL2, IFNA1, IFNA2, SRF
10	immunodeficiency	27.1	CD69, IL13, IL2, IL2RA, IL5, IFNA1
11	meningioma	27.1	AR, FGFR1, IL3, CCL11, IFNA1, F5
12	t-cell leukemia	26.7	JUN, IL2, IL2RA, IL3, IL5, SRF
13	gastroenteritis	26.7	IL2, IL5, CCL11, IGES, IGHE, IFNA1
14	acute myocardial infarction	26.7	JAK2, IL2RA, IGES, IGHE, F5, SRF
15	myeloproliferative disorder	26.6	KIT, JAK2, FGFR1, IL3, IFNA1, IFNA2
16	leukemia/lymphoma	26.5	FGFR1, IL2, IL2RA, IFNA1, IFNA2, TNFSF8
17	myocardial infarction	26.2	JAK2, AR, IL13, IL2RA, IL5, CCL11
18	neutropenia	26.1	JAK2, IL3, IGHE, IFNA1, IFNA2, TRD@
19	myelofibrosis	25.9	KIT, JAK2, IL3
20	acute lymphoblastic leukemia	25.9	KIT, JUN, JAK2, IL3, TRD@, TNFSF8
21	peripheral t-cell lymphoma	25.8	JAK2, IL13, IL2, IL5, CCL11, IGES
22	severe congenital neutropenia	25.8	IL3, CSF2
23	allergic rhinitis	25.8	IL13, IL5, IGES, IGHE, RNASE3
24	fibromatosis	25.7	KIT, AR, PDGFRA, PDGFRB
25	non-hodgkin lymphoma	25.7	JAK2, FGFR1, IL2, IL2RA, IL3, TNFSF8
26	aplastic anemia	25.6	IL2RA, IL3, NFATC2, CSF2, EPX
27	bronchitis	25.6	IL13, IL5, CCL11, IGHE, RNASE3
28	alzheimer's disease	25.5	JUN, CD69, AR, FGFR1, IL2, IL2RA
29	diabetes mellitus	25.5	JUN, CD69, AR, IL2, IL2RA, IL5
30	pulmonary tuberculosis	25.5	IL2, IL2RA, IGES
31	infertility	25.5	KIT, CD69, AR, IL5, F5, SRF
32	eosinophilia	25.4	CLC, JAK2, CD69, FIP1L1, FGFR1, IL13
33	periodontitis	25.4	JUN, IL13, IL2, IL2RA, IL3, IL5
34	esophageal carcinoma	25.3	KIT, IL2RA, IFNA1, IFNA2, PDGFRB, TGFA
35	erythrocytosis	25.3	JAK2, IL3, IFNA1, F5
36	cervicitis	25.3	KIT, JUN, FGFR1, IL13, IL2, IL2RA
37	hemophilia	25.2	IFNA1, IFNA2, F5, SRF
38	pericarditis	25.1	IL2, IGHE, IFNA2
39	hypoxia	24.9	KIT, JUN, AR, IL13, CCL11, IFNA1
40	hernia	24.9	AR, IGHE, PDGFRA, WT1, TGFA, CSF2
41	osteoarthritis	24.8	JUN, CD69, AR, FGFR1, IL13, IL2
42	retinoblastoma	24.8	KIT, JUN, AR, FGFR1, IL2, IGHE
43	ataxia telangiectasia	24.8	JUN, CD69, IGHE, WT1, ABL1
44	congenital myasthenic syndrome	24.7	AR, IL2, IL2RA, IL5, IFNA1
45	acute promyelocytic leukemia	24.7	IL3, IL5, IFNA1, IFNA2, F5, WT1
46	visceral leishmaniasis	24.7	IL13, IL2, IL2RA, IGHE, F5
47	mastocytosis	24.7	KIT, JAK2, CD69, FIP1L1, FGFR1, IL13
48	thrombosis	24.6	JAK2, IL2, IL3, IGES, IGHE, IFNA1
49	acute pancreatitis	24.6	FGFR1, IL2, IL2RA, IL5, IGHE, IFNA1
50	hodgkin's lymphoma	24.6	JAK2, IL13, IL2, IL2RA, IL3, CCL11

Approved drugs:

Drug clinical trials:

Genetic tests related to hypereosinophilic syndrome:

id	Genetic test	Affiliating Genes
1	Hypereosinophilic Syndrome clinical/research	PDGFRA

MalaCards organs/tissues related to hypereosinophilic syndrome:

²²

MGI Mouse Phenotypes related to hypereosinophilic syndrome:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	FGFR1, IL2, WT1
2	respiratory system phenotype	MP:0005388	9.5	NFATC2, PLA2G4A, SRF, PRG2, TRD@
3	embryogenesis phenotype	MP:0005380	9.4	KIT, FGFR1, NFATC2, PDGFRA, ABL1, CSF2
4	no phenotypic analysis	MP:0003012	9.4	SRF, IL13, CD69, FGFR1
5	reproductive system phenotype	MP:0005389	9.3	C5AR1, WT1, PDGFRA, PLA2G4A, IL13, CSF2
6	liver/biliary system phenotype	MP:0005370	8.8	IL2, ABL1, TRD@, KIT, AR
7	digestive/alimentary phenotype	MP:0005381	8.7	TGFA, ABL1, PDGFRB, AR, FGFR1, TRD@
8	other phenotype	MP:0005395	8.7	CSF2, JAK2, IL13, IL2, PLA2G4A, PDGFRA
9	integument phenotype	MP:0010771	8.7	KIT, F5, IL13, TRD@, PDGFRA, TGFA
10	renal/urinary system phenotype	MP:0005367	8.6	WT1, AR, PDGFRB, PDGFRA, PLA2G4A, FGFR1
11	immune system phenotype	MP:0005387	8.2	ABL1, C5AR1, CSF2, SRF, KIT, FGFR1
12	muscle phenotype	MP:0005369	8.0	TGFA, AR, ABL1, PDGFRB, PDGFRA, NFATC2
13	tumorigenesis	MP:0002006	7.9	AR, JAK2, KIT, IL3, IL5, TRD@
14	hematopoietic system phenotype	MP:0005397	7.8	KIT, CCL11, EPX, C5AR1, NFATC2, PRG2
15	mortality/aging	MP:0010768	7.5	PDGFRA, JAK2, IL2RA, F5, TRD@, PDGFRB
16	normal phenotype	MP:0002873	7.1	CCL11, JAK2, JUN, KIT, FGFR1, SRF
17	skeleton phenotype	MP:0005390	7.0	SRF, C5AR1, NFATC2, CSF2, TGFA, KIT
18	cardiovascular system phenotype	MP:0005385	6.4	F5, IL2, FGFR1, AR, JUN, CSF2
19	behavior/neurological phenotype	MP:0005386	6.3	SRF, KIT, JUN, AR, FGFR1, IL5
20	homeostasis/metabolism phenotype	MP:0005376	5.5	C5AR1, CSF2, ABL1, WT1, PDGFRB, PDGFRA
21	growth/size phenotype	MP:0005378	5.1	TGFA, CSF2, ABL1, WT1, PDGFRB, PDGFRA
22	cellular phenotype	MP:0005384	4.9	AR, KIT, JUN, JAK2, CD69, CD3G

Articles related to hypereosinophilic syndrome:

(show top 50)    (show all 76)

id	Title	Authors	Year	Affiliating Genes
1	Genetic mutations and molecularly-targeted drugs in hypereosinophilic syndromes]. (21399396)	Yamada Y.	2011	PDGFRA, FIP1L1
2	Novel imatinib-sensitive PDGFRA-activating point muta tions in hypereosinophilic syndrome induce growth factor independence and leuke mia-like disease. (21224473)	Elling C.... Koschmieder S.	2011	PDGFRA
3	Hypereosinophilic syndromes: pathogenic and therapeu tic up-to-date (20303627)	Kahn J.E.... BlActry O.	2010	PDGFRA
4	A review of treatment with mepolizumab, an anti-IL-5 mAb, in hypereosinophilic syndromes and asthma. (20371394)	Busse W.W.... Kahn J.E.	2010	IL5
5	The hypereosinophilic syndromes: current concepts and treatments. (19243381)	Gleich G.J.... Leiferman K.M.	2009	IL5
6	T-cell abnormalities are present at high frequencies in patients with hypereosinophilic syndrome. (19734416)	Helbig G.... Kyrcz-Krzemien S.	2009	TRD@
7	A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome. (19210352)	Salemi S.... Simon H.U.	2009	PDGFRA
8	Hypereosinophilic syndrome and proliferative diseases . (20021987)	Ionescu M.A.... Janin A.	2009	IL5
9	Screening for JAK2 V617F point mutation in patients with hypereosinophilic syndrome-in response to 'Hypereosinophilic syndrome: another face of janus?' by Dahabreh et al. published in Leukemia Research, in press. (18466967)	Helbig G.... KrzemieA8 S.	2009	JAK2
10	Oral mucosa lesions in hypereosinophilic syndrome--an update. (18194138)	Ionescu M.A.... Janin A.	2008	IL5
11	Elevated serum levels of soluble interleukin-2 receptor in chronic eosinophilic leukemia/hypereosinophilic syndrome with FIP1L1-PDGFR alpha fusion gene. (18365140)	Kataoka K.... Kurokawa M.	2008	IL2RA
12	Clinical features of hypereosinophilic syndrome: FIP1L1-PDGFRA fusion gene-positive disease is a distinct clinical entity with myeloproliferative features and a poor response to corticosteroid. (17261495)	Miyazawa K.... Ohyashiki K.	2007	PDGFRA, FIP1L1
13	A multicenter analysis of the FIP1L1-alphaPDGFR fusion gene in Japanese idiopathic hypereosinophilic syndrome: an aberrant splicing skipping the alphaPDGFR exon 12. (17701174)	Sada A.... Matsui T.	2007	PDGFRA
14	The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study. (17666373)	Baccarani M.... Martinelli G.	2007	PDGFRA, FIP1L1
15	WT1 transcript amount discriminates secondary or reactive eosinophilia from idiopathic hypereosinophilic syndrome or chronic eosinophilic leukemia. (17508006)	Cilloni D.... Saglio G.	2007	WT1
16	Hypereosinophilic syndrome--recent developments in diagnosis and treatment (17823882)	Hellmich B.... Gross W.L.	2007	IL5
17	Hypereosinophilic syndrome, chronic eosinophilic leuk emia, and mast cell disease. (18032976)	Pardanani A.... Verstovsek S.	2007	IFNA1
18	Hypereosinophilic syndrome: diagnosis and treatment. (17940488)	Peros-GolubiciA8 T.... Smojver-Jezek S.	2007	PDGFRA, IL5
19	A man with oral ulcers caused by hypereosinophilic syndrome and a good response to the tyrosine-kinase inhibitor imatinib (16768284)	Verstappen M.C.... de Vries R.A.	2006	PDGFRA, FIP1L1
20	The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease. (16418325)	Yamada Y.... Cancelas J.A.	2006	PDGFRA, IL5
21	Factor V Leiden mutation and deep venous thrombosis in a patient with hypereosinophilic syndrome. (16951787)	Aslan V.... Entok E.	2006	F5
22	Platelet-derived growth factor receptor-alpha-associated hypereosinophilic syndrome and lymphomatoid papulosis. (16965435)	McPherson T.... Klion A.D.	2006	PDGFRA
23	A clonal hypereosinophilic syndrome with specific and effective therapy: a report of two cases. (17214097)	Ellis M.H.... Amariglio N.	2006	PDGFRA
24	Idiopathic hypereosinophilic syndrome: toward a new molecular-targeted therapy and a new cytomorphological and molecular definition (15951264)	Moles M.P.... Blanchet O.	2005	PDGFRA, FIP1L1
25	Interferon treatment for hypereosinophilic syndromes and systemic mastocytosis. (15995323)	Butterfield J.H.	2005	IFNA1
26	Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics. (15772698)	Roche-Lestienne C.... Preudhomme C.	2005	PDGFRA, IL5, FIP1L1
27	Efficacy of imatinib mesylate in a patient with idiop athic hypereosinophilic syndrome and severe heart involvement. (15850007)	Anghel G.... Majolino I.	2005	IFNA1
28	Imatinib therapy for hypereosinophilic syndrome and eosinophilia-associated myeloproliferative disorders. (15036941)	Pardanani A.... Tefferi A.	2004	PDGFRA, PDGFRB
29	Platelet-derived growth factor receptor inhibition to treat idiopathic hypereosinophilic syndrome. (15175999)	Stone R.M.... Klion A.D.	2004	FIP1L1
30	A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. (12660384)	Cools J.... Gilliland D.G.	2003	PDGFRA, FIP1L1
31	Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. (12676775)	Klion A.D.... Nutman T.B.	2003	PDGFRA, KIT, FIP1L1
32	Peripheral T-cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome. (12950242)	GutiAcrrez A.... RodrA-guez J.	2003	IL2, CSF2
33	Dermal endothelial cells express eotaxin in hypereosinophilic syndrome. (14576680)	Tsunemi Y.... Tamaki K.	2003	CCL11
34	Hypereosinophilic syndrome induced by neonatal immunization against MHC class II alloantigen: critical role of IL-4. (11754358)	Le Moine A.... Goldman M.	2002	IL13, IL5
35	Horton's disease and hypereosinophilic syndrome: a n on-fortuitous association (11139663)	Liozon E.... Vidal E.	2000	IGHE
36	Analysis of Wilms tumor gene (WT1) expression in acute leukemia patients with special reference to the differential diagnosis between eosinophilic leukemia and idiopathic hypereosinophilic syndromes. (10674900)	Menssen H.D.... Thiel E.	2000	WT1
37	Clonality of isolated eosinophils in the hypereosinophilic syndrome. (10029594)	Chang H.W.... Lee S.H.	1999	AR
38	Study of release of eosinophil cationic proteins (ECP and EPX) in the hypereosinophilic syndrome (HES) and other hypereosinophilic conditions. (9785914)	Bobbio-Pallavicini E.... De Amici M.	1998	EPX, RNASE3
39	Distinction of eosinophilic leukaemia from idiopathic hypereosinophilic syndrome by analysis of Wilms' tumour gene expression. (9609529)	Menssen H.D.... Thiel E.	1998	WT1
40	A case of hypereosinophilic syndrome is associated with the expansion of a CD3-CD4+ T-cell population able to secrete large amounts of interleukin-5. (8608231)	Brugnoni D.... Tucci A.	1996	IL5
41	Deposits of eosinophil granule proteins in eosinophilic cholecystitis and eosinophilic colitis associated with hypereosinophilic syndrome. (8601370)	Tajima K.... Katagiri T.	1996	IL2RA, IL5
42	Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor. (8534765)	Endo M.... Urabe A.	1995	CSF2, IL5
43	Increased circulating levels of interleukin-5 in a case of steroid-resistant hypereosinophilic syndrome with ileal involvement. Longcope Firm of the Osler Housestaff. (8027491)	Fang J.... Bochner B.S.	1994	IL5
44	Hypereosinophilic syndrome associated with HIV infection. Military Medical Consortium for Applied Retroviral Research. (8153785)	Drabick J.J.... Benson P.M.	1994	IGHE
45	Interleukin-5 mRNA levels in blood and bone marrow mononuclear cells from patients with the idiopathic hypereosinophilic syndrome. (7835952)	Satoh T.... Spry C.J.	1994	IL5
46	Elevated production of interleukin-4 and interleukin-5 by T cells in a child with idiopathic hypereosinophilic syndrome. (8006315)	Takamizawa M.... Minami M.	1994	IL5
47	Interleukin-5 is the predominant eosinophilopoietin produced by cloned T lymphocytes in hypereosinophilic syndrome. (8425573)	Schrezenmeier H.... Raghavachar A.	1993	IL5
48	Elevated serum levels of soluble interleukin-2 receptor: a marker of disease activity in the hypereosinophilic syndrome. (1726707)	Prin L.... Capron M.	1991	IL2RA
49	A case of hypereosinophilic syndrome followed by bro nchial asthma, intraventricular thrombus, and duodenitis (1753511)	Ohtsuka Y.... Kawakami Y.	1991	IL5
50	Hypereosinophilic syndrome evolving to acute lymphoblastic leukemia. (1747458)	Takai K.... Sanada M.	1991	RNASE3

Genes related to hypereosinophilic syndrome according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.1	Summaries, Publications
2	FIP1L1	FIP1 like 1 (S. cerevisiae)	11.1	Publications, Summaries
3	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.1	Summaries, Publications
4	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
5	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
6	IGES	immunoglobulin E concentration, serum	11.0	Publications
7	EPX	eosinophil peroxidase	11.0	Publications
8	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0
9	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	11.0
10	C5AR1	complement component 5a receptor 1	11.0
11	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
12	CD69	CD69 molecule	11.0
13	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
14	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
15	WT1	Wilms tumor 1	11.0	Publications
16	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
17	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	11.0	Publications
18	TGFA	transforming growth factor, alpha	11.0
19	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0
20	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11.0
21	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
22	IFNA1	interferon, alpha 1	11.0	Publications
23	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
24	CLC	Charcot-Leyden crystal protein	11.0	Publications
25	TRD@	T cell receptor delta locus	11.0	Publications
26	CD3G	CD3g molecule, gamma (CD3-TCR complex)	11.0	Publications
27	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
28	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	11.0	Publications
29	JAK2	Janus kinase 2	11.0	Publications
30	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
31	IL13	interleukin 13	11.0	Publications
32	IFNA2	interferon, alpha 2	11.0	Publications
33	AR	androgen receptor	11.0	Publications
34	JUN	jun proto-oncogene	11.0	Publications
35	IL2	interleukin 2	11.0	Publications

Pathways related to hypereosinophilic syndrome according to GeneDecks:

(show top 50)    (show all 104)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.1	IL2
2	Asthma20	9.5	RNASE3, CCL11, IL5, IL3, PRG2, EPX
3	PTEN Pathway36	9.4	PRG2, PDGFRA, IL2RA, IL2, FGFR1, KIT
4	Tyrosine Kinases / Adaptors3	9.4	IL2RA, PDGFRA, FGFR1, PDGFRB, JAK2, KIT
5	PPAR Pathway36	9.3	IL3, IL2RA, KIT, PDGFRA, PDGFRB, FGFR1
6	Apoptotic Pathways in Synovial Fibroblasts36	9.2	PDGFRA, IL2RA, TGFA, PDGFRB, IL3, FGFR1
7	Telomerase Components in Cell Signaling36	9.2	TGFA, KIT, FGFR1, IL2, PDGFRA, PDGFRB
8	RAR-Gamma-RXR-Alpha Degradation36	9.2	IL3, CSF2, IL2, CCL11, TNFSF8
9	p53 Mediated Apoptosis36	9.2	TGFA, PDGFRB, PDGFRA, IL3, KIT, FGFR1
10	Mitochondrial Apoptosis36	9.2	IL2, KIT, TGFA, IL2RA, IL3, PDGFRA
11	ERK5 Signaling36	9.1	KIT, IL2, IL2RA, IL3, PDGFRA, PDGFRB
12	Cellular Apoptosis Pathway36	9.1	FGFR1, PDGFRA, IL3, PDGFRB, KIT, IL2
13	Akt Signaling36	9.1	CCL11, CSF2, PDGFRB, PDGFRA, KIT, FGFR1
14	eIF2 Pathway36	9.1	FGFR1, KIT, IL3, IL2, IL2RA, PDGFRA
15	Nuclear Receptor Activation by Vitamin-A36	9.1	PDGFRA, PDGFRB, TGFA, IL2RA, IL2, FGFR1
16	DHA Signaling36	9.0	KIT, TGFA, PLA2G4A, FGFR1, IL2, IL2RA
17	Activation of PKC through GPCR36	8.9	PDGFRA, PDGFRB, TGFA, IL2RA, IL2, FGFR1
18	MIF Mediated Glucocorticoid Regulation36	8.9	CSF2, IL3, IL2, IL13, IL5, CCL11
19	Rac1 Pathway36	8.8	IL2RA, JUN, FGFR1, IL2, IL3, PDGFRB
20	p70S6K Signaling36	8.8	KIT, JAK2, FGFR1, IL2, IL2RA, IL3
21	Cytokine Network36	8.8	IL13, IFNA2, IL2, IL3, IL5, IFNA1
22	all-trans-Retinoic Acid Signaling in Brain36	8.8	IL13, IL2, IL3, CSF2, IL5, CCL11
23	PGC1Alpha Pathway36	8.7	NFATC2, CCL11, IL5, IL2RA, IL2, IL13
24	Ras Pathway36	8.6	IL3, KIT, JUN, FGFR1, TGFA
25	PEDF Induced Signaling36	8.6	IL2, CSF2, CCL11, TNFSF8, SRF, IL5
26	NFAT Signaling and Lymphocyte Interactions36	8.6	IL3, NFATC2, IL2RA, IL2, IL13, CD3G
27	JNK Pathway36	8.4	KIT, CCL11, JUN, FGFR1, IL2, PDGFRB
28	STAT3 Pathway36	8.4	TNFSF8, CCL11, IL5, IL2RA, IL2, IL13
29	cAMP Pathway36	8.3	IL2, PDGFRB, KIT, PDGFRA, NFATC2, PLA2G4A
30	Phospholipase-C Pathway36	8.3	PRG2, PDGFRA, TGFA, PDGFRB, IL3, FGFR1
31	MIF Regulation of Innate Immune Cells36	8.2	IL5, IL3, IL2, IL13, JUN, CCL11
32	PAK Pathway36	8.1	TNFSF8, PDGFRA, PDGFRB, CCL11, IL5, IL2RA
33	14-3-3 Induced Intracellular Signaling36	8.1	FGFR1, IL3, KIT, JUN, IL2, PDGFRA
34	MAPK Signaling36	8.1	KIT, PRG2, TGFA, PDGFRB, FGFR1, PDGFRA
35	Measles20	8.1	IL2, IFNA2, IL13, IL2RA, JAK2, IFNA1
36	Renin-Angiotensin Pathway36	8.1	TGFA, PDGFRB, PDGFRA, IL3, IL2RA, IL2
37	Jak-STAT signaling pathway20	8.0	JAK2, IFNA1, CSF2, IFNA2, IL3, IL2RA
38	Tec Kinases Signaling36	8.0	FGFR1, CD3G, JAK2, IL13, IL5, IL2
39	TGF-Beta Pathway36	7.9	JUN, FGFR1, IL13, IL2, IL2RA, IL3
40	NFAT in Immune Response36	7.9	KIT, JUN, CD3G, FGFR1, IL2, IL3
41	GPCR Pathway36	7.9	TGFA, PDGFRB, PDGFRA, NFATC2, IL3, IL2
42	p38 Signaling36	7.8	IL13, FGFR1, CD3G, KIT, IL2, IL2RA
43	MAPK Family Pathway36	7.8	TGFA, IL2RA, IL5, IL3, IL2, IL13
44	Cytokine-cytokine receptor interaction20	7.8	CCL11, IL5, IL3, IL2, IL2RA, IL13
45	Endothelin-1 Signaling Pathway36	7.7	JUN, IL2, KIT, FGFR1, IL13, CSF2
46	Molecular Mechanisms of Cancer36	7.6	ABL1, JUN, FGFR1, IL13, IL3, IL5
47	Rho Family GTPases36	7.3	CSF2, KIT, JUN, FGFR1, IL13, IL2
48	Antioxidant Action of Vitamin-C36	6.8	IL3, IL5, CCL11, TNFSF8, PLA2G4A, PDGFRA
49	ERK Signaling36	6.7	IL3, IL5, CCL11, TNFSF8, SRF, PDGFRA
50	JAK-STAT Pathway36	6.6	PDGFRA, IFNA2, IFNA1, CCL11, IL5, IL3

Compounds related to hypereosinophilic syndrome according to GeneDecks:

(show top 50)    (show all 247)

id	Compound	Score	Top Affiliating Genes
1	aspartate32	9.8	ABL1, EPX, C5AR1, F5
2	budesonide32 42 9 9	12.8	EPX, CSF2, RNASE3, IGHE, CCL11
3	agar32	9.8	JAK2, FGFR1, PDGFRB, ABL1, TGFA
4	cetirizine32 9 18 9	12.7	IL5, CSF2, IGHE, CCL11, RNASE3, EPX
5	ionomycin32	9.5	CSF2, CD69, IL3, IL5, CCL11, PLA2G4A
6	pgd232	9.4	IL13, IL5, CCL11, PLA2G4A, RNASE3, PRG2
7	ly29400232	9.2	PLA2G4A, JUN, IL13, CD69
8	methacholine32 9 9	11.1	RNASE3, IGHE, IL5, CSF2, IL13, CCL11
9	allergens32	9.1	PRG2, IGES, CCL11, IL5, IL13, CD69
10	estrogen32	9.1	AR, IGHE, RNASE3, PDGFRA, PDGFRB, WT1
11	fluticasone propionate32 42 9 9	12.1	CSF2, RNASE3, PLA2G4A, IGHE, IL5, IL13
12	cysteine32	9.0	PLA2G4A, PDGFRB, TGFA, CSF2, C5AR1, EPX
13	leukotriene b432 42 18	10.9	EPX, IL13, IL5, IL3, C5AR1, CSF2
14	ltc432	8.9	C5AR1, EPX, CSF2, PRG2, IL13, IL3
15	salmeterol32 42 9 9	11.9	IL13, IL2, IL5, CCL11, PLA2G4A, RNASE3
16	heparin32 9 18 9	11.9	RNASE3, TGFA, PRG2, CSF2, C5AR1, EPX
17	imatinib32 34 9 9	11.8	PDGFRA, PDGFRB, ABL1, WT1, IFNA1, IL5
18	rapamycin32 42	9.7	KIT, PDGFRB, JAK2, AR, IL2, PLA2G4A
19	gp 13032	8.7	TGFA, IL3, IL2RA, IL13, JAK2, KIT
20	fmlp32	8.7	PLA2G4A, CSF2, EPX, CD69, PRG2, RNASE3
21	pge232	8.7	IL13, IL5, CCL11, PLA2G4A, TGFA, C5AR1
22	il-1232	8.5	IL2, CSF2, IL5, IFNA1, SRF, IL13
23	prednisolone32 9 9	10.0	IL2, IL2RA, IL5, CCL11, IGHE, IFNA1
24	5fluorouracil32	8.0	IFNA1, CSF2, TGFA, PDGFRB, SRF, IFNA2
25	hydroxyurea32 9 9	9.9	KIT, CSF2, PDGFRA, IL3, IFNA2, IFNA1
26	tacrolimus32 34 9 9	10.8	CD69, IL13, IL2RA, IL3, IL5, CCL11
27	lactate32	7.8	EPX, CSF2, IGES, IL3, IL13, FGFR1
28	polysaccharide32	7.7	IL3, AR, CD69, FGFR1, IGHE, F5
29	herbimycin a32 42	8.6	CSF2, PLA2G4A, CCL11, IL5, IL3, IL2RA
30	indomethacin32 9 9	9.6	JAK2, IL13, IL2RA, IL5, IL2, CCL11
31	rantes32	7.5	IFNA1, CSF2, C5AR1, RNASE3, CCL11, IL3
32	vegf32	7.5	WT1, ABL1, CSF2, C5AR1, PDGFRB, PDGFRA
33	pd 98,05932	7.4	JUN, IL13, KIT, JAK2, IL3, FGFR1
34	nitric oxide32 9 18 9	10.4	EPX, F5, PRG2, WT1, CD69, RNASE3
35	vitamin d32	7.2	PLA2G4A, JUN, AR, IL2RA, C5AR1, CSF2
36	oligonucleotide32	7.2	WT1, FGFR1, SRF, NFATC2, RNASE3, PDGFRA
37	calcitriol32 42 9 18 9	11.1	AR, IL13, IL2, IL2RA, IL3, PLA2G4A
38	steroid32	6.9	EPX, TGFA, IFNA2, WT1, RNASE3, F5
39	phosphatidylinositol32	6.6	IL3, CCL11, SRF, PLA2G4A, PDGFRA, PDGFRB
40	h2o232	6.6	JUN, TGFA, CSF2, C5AR1, EPX, ABL1
41	histamine32 18	7.5	CCL11, EPX, C5AR1, IGES, IGHE, IFNA2
42	genistein32 9 18 9	9.3	FGFR1, PLA2G4A, SRF, CCL11, IL5, IL3
43	actinomycin d32	6.1	KIT, JUN, JAK2, CD69, AR, IL13
44	cycloheximide32	5.9	KIT, TGFA, CSF2, C5AR1, PLA2G4A, SRF
45	cyclosporin a32 42	6.8	JUN, JAK2, CD69, IL13, IL2, IL2RA
46	thymidine32 18	6.8	KIT, JUN, JAK2, CD69, FGFR1, IL13
47	dexamethasone32 42 34 9 9	9.7	IL3, IL5, CCL11, IGHE, IFNA1, SRF
48	serine32	5.1	JUN, EPX, FGFR1, IL3, KIT, IL2
49	retinoic acid32 42 18	6.7	KIT, SRF, RNASE3, PDGFRA, PDGFRB, WT1
50	tyrosine32	4.2	KIT, JUN, IFNA2, SRF, PLA2G4A, RNASE3

Cellular components related to hypereosinophilic syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic to plasma membrane	GO:031226	10.2	PDGFRA, PDGFRB
2	extracellular space	GO:005615	7.2	IL13, IL2, IL3, IL5, CCL11, IFNA2
3	extracellular region	GO:005576	7.0	FGFR1, CSF2, IL13, IL2, IL3, IL5

Biological processes related to hypereosinophilic syndrome according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	metanephric glomerular capillary formation	GO:072277	10.4	PDGFRB, PDGFRA
2	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.4	PDGFRA, PDGFRB
3	cell chemotaxis	GO:060326	10.4	KIT, PDGFRA, PDGFRB
4	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.3	KIT, PDGFRA, PDGFRB
5	positive regulation of phospholipase C activity	GO:010863	10.3	FGFR1, PDGFRA, PDGFRB, KIT
6	positive regulation of podosome assembly	GO:071803	10.3	IL5, CSF2
7	cardiac myofibril assembly	GO:055003	10.2	SRF, PDGFRB, PDGFRA
8	platelet-derived growth factor receptor signaling pathway	GO:048008	10.1	JAK2, PDGFRA, PDGFRB
9	mast cell chemotaxis	GO:002551	10.1	CCL11, KIT
10	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	KIT, JAK2, PDGFRA, PDGFRB, FGFR1
11	protein autophosphorylation	GO:046777	9.8	PDGFRA, KIT, JAK2, FGFR1, PDGFRB
12	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.8	SRF, IL5, KIT, JAK2
13	peptidyl-tyrosine phosphorylation	GO:018108	9.7	PDGFRB, KIT, JAK2, FGFR1, PDGFRA, ABL1
14	positive regulation of cell migration	GO:030335	9.7	JAK2, PDGFRB, PDGFRA, CCL11
15	response to radiation	GO:009314	9.5	CCL11, KIT, JUN
16	positive regulation of DNA replication	GO:045740	9.4	JUN, CSF2, PDGFRA, IL3
17	elevation of cytosolic calcium ion concentration	GO:007204	9.4	PDGFRA, IL2, C5AR1, JAK2
18	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.4	IL3, CSF2, KIT, JAK2, IL2
19	positive regulation of B cell proliferation	GO:030890	9.4	NFATC2, IL13, IL2, IL5
20	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	PDGFRB, IL13, JUN
21	response to lipopolysaccharide	GO:032496	8.3	JAK2, IL13, PLA2G4A, JUN
22	cell-cell signaling	GO:007267	8.3	AR, IL13, IL2, IL3, IFNA2, TNFSF8
23	immune response	GO:006955	8.3	C5AR1, CSF2, PRG2, TNFSF8, IGHE, CCL11
24	positive regulation of cell proliferation	GO:008284	8.1	FGFR1, KIT, IL2, IL3, PLA2G4A, PDGFRA

Molecular functions related to hypereosinophilic syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor binding	GO:038085	10.2	PDGFRA, PDGFRB
2	protein tyrosine kinase activity	GO:004713	9.4	KIT, ABL1, PDGFRB, FGFR1, JAK2
3	growth factor activity	GO:008083	8.9	CSF2, TGFA, IL5, IL3, IL2
4	cytokine activity	GO:005125	8.3	IFNA2, CSF2, TNFSF8, IL5, IL13, IL2