HES
MCID: HYP098
MIFTS: 54

Hypereosinophilic Syndrome (HES) malady

Blood diseases, Cancer diseases categories

Summaries for Hypereosinophilic Syndrome

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Hypereosinophilic syndrome is a group of rare blood disorders characterized by increased levels of eosinophils (a type of white blood cell that plays a role in the human immune system) persisting for more than six months. the signs and symptoms are due to involvement of several internal organs and there is usually no evidence of parasites, allergy, or other known causes of an elevated eosinophil count. this condition largely occurs in males, typically at middle age. it usually presents with fever, weight loss, fatigue, and rash. an enlarged liver and spleen and liver is often present. the lungs, kidneys, heart, and nervous system can also be affected. last updated: 7/11/2011

MalaCards: Hypereosinophilic Syndrome, also known as hypereosinophilic syndrome, idiopathic, is related to leukemia and eosinophilia. An important gene associated with Hypereosinophilic Syndrome is PDGFRA (platelet-derived growth factor receptor, alpha polypeptide), and among its related pathways are Osteoblast Signaling and Alzheimers Disease Pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and bone, and related mouse phenotypes are renal/urinary system and respiratory system.

Wikipedia:63 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

Aliases & Classifications for Hypereosinophilic Syndrome

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42NIH Rare Diseases, 20GeneTests, 44Novoseek, 48Orphanet, 38NCBI Bookshelf, 22GTR, 60UMLS, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
hypereosinophilic syndrome:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

hypereosinophilic syndrome 42 20 44 48
hypereosinophilic syndrome, idiopathic 42 22
idiopathic hypereosinophilic syndrome 44 60
hes 42 38
chronic eosinophilic leukemia 60


External Ids:

UMLS via Orphanet61 C1540912
MESH via Orphanet35 D017681
ICD10 via Orphanet26 D47.5
SNOMED-CT via Orphanet57 128835008

Related Diseases for Hypereosinophilic Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Hypereosinophilic Syndrome family:

Primary Hypereosinophilic Syndrome

Diseases related to Hypereosinophilic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 327)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0C5AR1, FIP1L1, EPX, FGFR1, RNASE3, IL2RA
2eosinophilia30.7PRG2, CCL11, PDGFRB, PDGFRA, CSF2, IGHE
3endocarditis30.7EPX
4endomyocardial fibrosis30.7PDGFRA, FIP1L1
5eosinophilic gastroenteritis30.5IL5, IGHE, CCL11
6acute leukemia30.5CSF2, WT1, FGFR1, IL3, KIT
7vasculitis30.4PRG2
8hepatitis30.4IFNA1, CCL11
9asthma30.4IGHE, EPX, RNASE3, IL5
10churg-strauss syndrome30.3RNASE3, IL5
11myelofibrosis30.3IL3, KIT
12systemic mastocytosis30.2KIT, IL2RA, FGFR1, PDGFRA, PDGFRB
13ulcerative colitis30.2IL2RA, RNASE3, EPX, CCL11
14chronic myeloproliferative disease30.1PDGFRB
15cutaneous t cell lymphoma30.1IFNA1, IL2RA, IL5
16arthritis30.1CSF2, CD69, PLA2G4A, C5AR1
17multiple sclerosis30.1CCL11, IFNA1, PRG2, CD69, IL2RA, IL5
18systemic lupus erythematosus30.1C5AR1, IL2RA, CD69, IFNA1
19glomerulonephritis29.9C5AR1
20eosinophilic esophagitis29.9CCL11, IL5
21anaplastic large cell lymphoma29.9IL2RA, TNFSF8
22esophagitis29.9CCL11, PRG2, IL5
23uveitis29.9IL2RA, CD69, CCL11
24mycosis fungoides29.9IL5, IL2RA, IFNA1
25sarcoma29.9PDGFRB, PDGFRA, WT1, KIT
26cyclic hematopoiesis29.9IL3, CSF2
27dermatitis29.9CCL11, CSF2, IGHE, IL5
28myeloid leukemia29.9CSF2, WT1, IL3, KIT
29adenocarcinoma29.9PDGFRB, WT1, FGFR1, PLA2G4A
30urticaria29.9PRG2, IGHE, RNASE3, C5AR1
31bullous pemphigoid29.9CCL11, PRG2, IGHE, RNASE3, IL5
32hodgkin's lymphoma29.9CCL11, CSF2, TNFSF8, IL2RA, IL3
33thrombocytopenia29.9IL3, CSF2, IFNA1
34chronic myeloid leukemia29.9IFNA1, PDGFRB, PDGFRA, CSF2, WT1, FGFR1
35rheumatoid arthritis29.9CD69, RNASE3, IL2RA, PLA2G4A, C5AR1, PRG2
36bronchitis29.8RNASE3
37acute pancreatitis29.8FGFR1
38retinoblastoma29.8WT1
39obesity29.8PLA2G4A, FGFR1, CCL11
40pdgfrb-associated chronic eosinophilic leukemia10.7
41cerebritis10.4
42image syndrome10.4
43gastroenteritis10.3
44myocardial infarction10.3
45restrictive cardiomyopathy10.3
46hypereosinophilic syndrome, idiopathic, resistant to imatinib10.3
47primary hypereosinophilic syndrome10.3
48t-cell leukemia10.2
49myocarditis10.2
50secondary hypereosinophilic syndrome10.2

Graphical network of the top 20 diseases related to Hypereosinophilic Syndrome:



Diseases related to hypereosinophilic syndrome

Clinical Features for Hypereosinophilic Syndrome

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Drugs & Therapeutics for Hypereosinophilic Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypereosinophilic Syndrome

Drug clinical trials:

Search ClinicalTrials for Hypereosinophilic Syndrome

Search NIH Clinical Center for Hypereosinophilic Syndrome

Search CenterWatch for Hypereosinophilic Syndrome

Genetic Tests for Hypereosinophilic Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Hypereosinophilic Syndrome:

id Genetic test Affiliating Genes
1 Hypereosinophilic Syndrome20 PDGFRA
2 Idiopathic Hypereosinophilic Syndrome22

Anatomical Context for Hypereosinophilic Syndrome

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32MalaCards
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MalaCards organs/tissues related to Hypereosinophilic Syndrome:

32
Liver, Heart, Bone, Kidney, Lung, Spleen, Bone marrow

Animal Models for Hypereosinophilic Syndrome or affiliated genes

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36MGI
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Publications for Hypereosinophilic Syndrome

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Genetic Variations for Hypereosinophilic Syndrome

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Expression for genes affiliated with Hypereosinophilic Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypereosinophilic Syndrome

Search GEO for disease gene expression data for Hypereosinophilic Syndrome.

Pathways for genes affiliated with Hypereosinophilic Syndrome

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome, 49PharmGKB, 29KEGG, 59Tocris Bioscience
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Pathways related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PDGFRB, PDGFRA
210.1FGFR1, PDGFRA, PDGFRB
310.1FGFR1, PDGFRA, PDGFRB
410.1PDGFRB, PDGFRA, FGFR1
5
Hide members
10.1IL5, IL2RA, CCL11
610.1CCL11, IL5, C5AR1
710.1CCL11, IGHE, IL5
810.0IFNA1, IL3, IL5
9
Hide members
10.0KIT, FGFR1, PDGFRA, PDGFRB
10
Hide members
10.0PDGFRB, PDGFRA, FGFR1, KIT
11
Hide members
10.0PDGFRB, PDGFRA, FGFR1, KIT
12
Hide members
10.0KIT, FGFR1, PDGFRA, PDGFRB
1310.0PDGFRB, PDGFRA, CSF2, IL2RA
14
Hide members
10.0PLA2G4A, FGFR1, PDGFRA, PDGFRB
15
Hide members
9.9CSF2, IL2RA, IL3, IL5
16
Hide members
9.9IL5, IL3, IL2RA, CSF2
17
Hide members
9.9PDGFRB, PDGFRA, FGFR1, IL2RA, IL5
189.9PDGFRB, PDGFRA, FGFR1, IL2RA, KIT
19
Hide members
9.9PDGFRB, PDGFRA, FGFR1, IL3, KIT
20
Hide members
9.8PDGFRB, PDGFRA, IGHE, FGFR1, KIT
219.8CSF2, IL2RA, IL3, IL5, KIT
229.8PDGFRA, WT1, FGFR1, IL3, PLA2G4A
23
Hide members
9.8IL5, IL3, IL2RA, CSF2, IFNA1
249.8IFNA1, CSF2, IL2RA, IL3, IL5
25
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9.7PDGFRB, PDGFRA, FGFR1, IL2RA, PLA2G4A, KIT
26
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL2RA, IL3, KIT
27
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL2RA, IL3, KIT
28
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL2RA, IL3, KIT
29
Hide members
9.7PDGFRB, PDGFRA, FGFR1, IL3, PLA2G4A, KIT
30
Hide members
9.6PDGFRB, PDGFRA, CSF2, TNFSF8, PRG2, FGFR1
319.5IFNA1, PDGFRB, PDGFRA, FGFR1, IL2RA, IL3
32
Hide members
9.5PDGFRB, PDGFRA, PRG2, FGFR1, IL2RA, IL3
33
Hide members
9.4CCL11, IFNA1, CSF2, IGHE, IL3, IL5
34
Hide members
9.4CCL11, IFNA1, PRG2, EPX, RNASE3, IL2RA
35
Hide members
9.2CCL11, PDGFRB, PDGFRA, CSF2, TNFSF8, FGFR1
36
Hide members
9.2IFNA1, PDGFRB, PDGFRA, CSF2, IGHE, FGFR1
37
Hide members
9.1CSF2, PDGFRA, PDGFRB, CCL11, TNFSF8, FGFR1
38
Hide members
8.9KIT, CCL11, IFNA1, PDGFRB, PDGFRA, CSF2

Compounds for genes affiliated with Hypereosinophilic Syndrome

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 195)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7RNASE3
2cycloheximide4410.6IFNA1
3pge24410.4EPX, CSF2, CCL11
4unicap4410.2IGHE, CCL11, RNASE3, IL5
5sodium cromoglycate4410.2CCL11, IL5, RNASE3, EPX, IGHE
6lte44410.2CCL11, RNASE3, EPX, IL5
7ketotifen44 1111.2CCL11, RNASE3, IL5, IGHE, EPX
8salmeterol44 49 28 1113.1EPX, RNASE3, CSF2, CCL11, IL5, PLA2G4A
9cetirizine44 28 11 2413.1RNASE3, IL5, CCL11, CSF2, EPX, IGHE
10montelukast44 49 28 1113.1IGHE, IL5, RNASE3, IL2RA, CCL11
11budesonide44 49 1112.1EPX, CSF2, CCL11, RNASE3, IL5, IGHE
12ag-12964410.1IL3, KIT, PDGFRA, PDGFRB
13nedocromil sodium4410.1IL5, IL3, RNASE3, IGHE
14salbutamol44 49 28 11 2414.0EPX, IL5, RNASE3, IGHE, CCL11
15fluticasone propionate44 49 59 1113.0IL5, PLA2G4A, RNASE3, IGHE, CSF2, CCL11
16n-formylmethionyl-leucylphenylalanine4410.0C5AR1, IL5, IL3, RNASE3, CSF2, CCL11
17methacholine44 1111.0RNASE3, IGHE, PRG2, CSF2, CCL11, IL5
18anaphylatoxin4410.0RNASE3, PLA2G4A, IL3, C5AR1, CSF2
19poly(i-c)4410.0CSF2, CCL11, IL5, IL3, CD69, IFNA1
20allergens449.9RNASE3, CD69, CCL11, PRG2, IL5, EPX
21dexamethasone44 49 28 1112.9RNASE3, EPX, IGHE, IL3, IFNA1, CCL11
22cytochalasin b449.9RNASE3, C5AR1, EPX, CSF2, PRG2
23leukotriene b444 59 2411.8CSF2, IL3, RNASE3, CCL11, C5AR1, PLA2G4A
24herbimycin a44 5910.8CSF2, PLA2G4A, IL5, IL3, IL2RA, CD69
25calcitriol44 59 11 2412.8PLA2G4A, IL3, WT1, CSF2, PDGFRA, PDGFRB
26rantes449.8IFNA1, C5AR1, IL3, IL2RA, CCL11, RNASE3
27vincristine44 49 1111.8IFNA1, IL3, KIT, WT1, CSF2, IL2RA
28pgd2449.8IGHE, PLA2G4A, C5AR1, IL5, CCL11, PRG2
29heparin44 28 11 2412.8CCL11, CSF2, C5AR1, IL2RA, RNASE3, EPX
30ionomycin449.8CCL11, CSF2, IL5, CD69, IL2RA, IL3
31imatinib44 49 1111.8FGFR1, IFNA1, IL3, PDGFRB, PDGFRA, WT1
32prednisolone44 28 1111.8CCL11, EPX, RNASE3, IL2RA, IGHE, IL5
33h2o2449.7C5AR1, PDGFRB, CSF2, EPX, FGFR1, IL3
34ivig449.7IL3, CSF2, IGHE
35ltc4449.7C5AR1, PLA2G4A, IL5, RNASE3, EPX, PRG2
36vitamin d449.6C5AR1, PLA2G4A, IL5, PDGFRB, IL3, IGHE
37fmlp449.5CCL11, IL5, PLA2G4A, C5AR1, CSF2, PRG2
38genistein44 28 59 2 11 2414.5CCL11, CSF2, PDGFRB, PRG2, CD69, FGFR1
39creatinine449.5RNASE3, EPX, CD69, IGHE, WT1, C5AR1
40actinomycin d449.5CCL11, KIT, PLA2G4A, IL3, CD69, PRG2
41cyclosporin a44 28 5911.4CCL11, IL5, IL3, IL2RA, RNASE3, CD69
42polysaccharide449.4CSF2, IGHE, IL3, CD69, FGFR1, RNASE3
43thymidine44 2410.4CD69, FGFR1, CCL11, IFNA1, PDGFRA, CSF2
44phosphatidylinositol449.3CCL11, PDGFRA, CSF2, CD69, FGFR1, C5AR1
45nitric oxide44 11 2411.2WT1, CD69, CCL11, EPX, FGFR1, RNASE3
46cysteine449.2PDGFRB, IL2RA, FGFR1, EPX, PRG2, WT1
47retinoic acid44 2410.1CSF2, WT1, PRG2, IGHE, FGFR1, RNASE3
48histamine44 28 2411.1CCL11, CSF2, PRG2, IGHE, EPX, FGFR1
49vegf449.0RNASE3, FGFR1, IGHE, WT1, CSF2, PDGFRA
50tyrosine448.5C5AR1, IFNA1, CCL11, PDGFRA, CSF2, KIT

GO Terms for genes affiliated with Hypereosinophilic Syndrome

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16Gene Ontology
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Cellular components related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to plasma membraneGO:03122610.2PDGFRA, PDGFRB
2extracellular spaceGO:0056159.7KIT, IL5, IL3, TNFSF8, CSF2, CCL11
3external side of plasma membraneGO:0098979.7PDGFRA, CD69, IL2RA, KIT
4extracellular regionGO:0055769.3IL5, CCL11, CSF2, PRG2, IGHE, FGFR1

Biological processes related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.6PDGFRB, PDGFRA
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.6PDGFRB, PDGFRA
3cell chemotaxisGO:06032610.5PDGFRB, PDGFRA, KIT
4positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.5KIT, PDGFRA, PDGFRB
5metanephric S-shaped body morphogenesisGO:07228410.5PDGFRB, WT1
6adrenal gland developmentGO:03032510.5WT1, PDGFRA, PDGFRB
7mast cell chemotaxisGO:00255110.5CCL11, KIT
8retina vasculature development in camera-type eyeGO:06129810.4PDGFRA, PDGFRB
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4KIT, IL3, CSF2
10positive regulation of podosome assemblyGO:07180310.4IL5, CSF2
11positive regulation of phospholipase C activityGO:01086310.4PDGFRB, PDGFRA, FGFR1, KIT
12positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.4KIT, FGFR1, PDGFRA, PDGFRB
13peptidyl-tyrosine phosphorylationGO:01810810.4PDGFRB, PDGFRA, FGFR1, KIT
14positive regulation of DNA replicationGO:04574010.4IL3, CSF2, PDGFRA
15metanephric mesenchyme developmentGO:07207510.3PDGFRB, WT1
16cardiac myofibril assemblyGO:05500310.3PDGFRA, PDGFRB
17phosphatidylinositol-mediated signalingGO:04801510.3PDGFRB, PDGFRA, FGFR1, KIT
18protein autophosphorylationGO:04677710.3PDGFRB, PDGFRA, FGFR1, KIT
19fibroblast growth factor receptor signaling pathwayGO:00854310.3KIT, FGFR1, PDGFRA, PDGFRB
20epidermal growth factor receptor signaling pathwayGO:00717310.2PDGFRB, PDGFRA, FGFR1, KIT
21Fc-epsilon receptor signaling pathwayGO:03809510.2PDGFRB, PDGFRA, IGHE, FGFR1, KIT
22positive regulation of cell proliferationGO:00828410.1PDGFRB, PDGFRA, CSF2, FGFR1, IL3, KIT
23neurotrophin TRK receptor signaling pathwayGO:04801110.0PDGFRB, PDGFRA, FGFR1, KIT
24positive regulation of ERK1 and ERK2 cascadeGO:07037410.0C5AR1, PDGFRA, PDGFRB
25inflammatory responseGO:00695410.0C5AR1, KIT, IL5, CCL11
26positive regulation of JAK-STAT cascadeGO:04642710.0IL5, KIT
27immune responseGO:0069559.5C5AR1, CCL11, CSF2, TNFSF8, PRG2, IGHE

Molecular functions related to Hypereosinophilic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.3PDGFRA, PDGFRB
2protein tyrosine kinase activityGO:00471310.1KIT, FGFR1, PDGFRB
3platelet-derived growth factor bindingGO:04840710.0PDGFRA, PDGFRB
4cytokine activityGO:0051259.8CSF2, TNFSF8, IL3, IL5

Products for genes affiliated with Hypereosinophilic Syndrome

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Sources for Hypereosinophilic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet