MCID: HYP066
MIFTS: 65

Hyperglycemia malady

Summaries for Hyperglycemia

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Hyperglycemia means high blood sugar or glucose. glucose comes from the foods you eat. insulin is a hormone that moves glucose into your cells to give them energy. hyperglycemia happens when your body doesn't make enough insulin or can't use it the right way. people with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. other problems that can raise blood sugar include infections, certain medicines, hormone imbalances, or severe illnesses.

MalaCards: Hyperglycemia, also known as hyperglycaemia, is related to diabetes mellitus and obesity. An important gene associated with Hyperglycemia is UNC13B (unc-13 homolog B (C. elegans)), and among its related pathways are Metabolism and Regulation of beta-cell development. The drugs insulin and insulin, aspart, human and the compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, kidney and liver, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Wikipedia:63 Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia, not to be confused... more...

Aliases & Classifications for Hyperglycemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Hyperglycemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus31.0GCK, GCG, GCGR, PDP1, AKR1B1, IAPP
2obesity30.7AKR1B1, GCG, GCGR, GCK, PDP1, IAPP
3pancreatitis30.7GCG, INS
4hypoglycemia30.7AKR1B1, INS, GIP, IAPP, PCK2, GCGR
5ischemia30.7GCK, GCG, PDP1, AHSP, AKR1B1
6type 2 diabetes mellitus30.6GLO1, GCGR, GCK, PDP1, PDX1, AKR1B1
7myocardial infarction30.6GCG, AKR1B1, AHSP, PDX1
8glucose intolerance30.3INS, IAPP, GCK, GCGR, GCG
9gestational diabetes30.3IAPP, GCK, GCG, INS
10diabetic nephropathy30.2IAPP, INS, AKR1B1
11vascular disease30.1GCG
12hyperinsulinism30.0GCK, INS, GIP, GCG
13coronary artery disease30.0AHSP, INS, GCG, AKR1B1
14permanent neonatal diabetes mellitus30.0GCK, INS
15diabetic neuropathy29.9INS, AKR1B1
16essential hypertension29.8IAPP, GCGR, AHSP, INS
17autonomic neuropathy29.8GCG, AKR1B1, INS
18diabetic autonomic neuropathy29.8AKR1B1
19insulin resistance29.7GCK, GCGR, PDP1, IAPP, INS, PAX4
20type 1 diabetes29.7GLO1, IAPP, PDX1, INS, PAX4, GCK
21insulinoma29.7INS, MAFA, PDX1, GCG, IAPP, PAX4
22metabolic syndrome x29.7IAPP, AKR1B1, GCK, GCG, INS
23maturity-onset diabetes of the young29.7INS, GCK, PDX1, PAX4
24lactic acidosis29.7GCG, INS
25neuroendocrine tumor29.7GCG
26hepatitis10.4
27cerebritis10.4
28retinitis10.4
29atherosclerosis10.3
30acute myocardial infarction10.3
31hypertension10.3
32leukemia10.3
33diabetic ketoacidosis10.3
34type 1 diabetes mellitus10.3
35acute leukemia10.3
36neuronitis10.1
37acute lymphocytic leukemia10.1
38kidney disease10.1
39stroke, ischemic10.1
40hypokalemia10.1
41metabolic acidosis10.1
42diabetic retinopathy10.1
43polyneuropathy10.1
44acute pancreatitis10.0
45diabetic polyneuropathy10.0
46hepatitis a10.0
47breast cancer10.0
48galactosemia10.0
49lymphopenia10.0
50methylmalonic acidemia10.0

Graphical network of the top 20 diseases related to Hyperglycemia:



Diseases related to hyperglycemia

Clinical Features for Hyperglycemia

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Genetic Tests for Hyperglycemia

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Anatomical Context for Hyperglycemia

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32MalaCards
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MalaCards organs/tissues related to Hyperglycemia:

32
Endothelial, Kidney, Liver, Brain, Heart, Smooth muscle, Skeletal muscle, Monocytes, Adipocyte, Lung, Testes, Prostate, Pancreas, Pancreatic islet, Breast, Bone, Thyroid, Bone marrow, Pituitary, Retina, Ovary, Dorsal root ganglion, Fetal liver, Cortex, Spinal cord, Small intestine, Eye, Thymus, Myeloid, Prefrontal cortex, Fetal brain

Animal Models for Hyperglycemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperglycemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.8PAX4, GCG, GCGR, GCK, PDX1, AKR1B1
2MP:000537611.5AKR1B1, PDX1, GCK, GCGR, GCG, IAPP
3MP:000536711.3GCG, GCK, PDX1, AKR1B1, FN3K, MAFA
4MP:000537911.3GCGR, GCK, PDX1, MAFA, INS, PAX4

Publications for Hyperglycemia

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Sources:
50PubMed
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Articles related to Hyperglycemia:

(show top 50)    (show all 1047)
idTitleAuthorsYear
1
Metformin protects against hyperglycemia-induced cardiomyocytes injury by inhibiting the expressions of receptor for advanced glycation end products and high mobility group box 1 protein. (24420848)
2014
2
An In Vitro Model to Probe the Regulation of Adipocyte Differentiation under Hyperglycemia. (23807920)
2013
3
Hyperglycemia within day 14 of aneurysmal subarachnoid hemorrhage predicts 1-year mortality. (23072944)
2013
4
Chronic hyperglycemia inhibits vasoregression in a transgenic model of retinal degeneration. (23771613)
2013
5
Lectin from Crataeva tapia Bark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice. (24324521)
2013
6
Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats. (23770360)
2013
7
Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets. (23833251)
2013
8
Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes. (22999997)
2013
9
Quality in Acute Stroke Care (QASC): process evaluation of an intervention to improve the management of fever, hyperglycemia, and swallowing dysfunction following acute stroke. (24289456)
2013
10
Effect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptin. (23220949)
2013
11
Decreased transcription of ChREBP-I+/I^ isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia. (23209190)
2013
12
Clinical impact of acute hyperglycemia on development of diabetes mellitus in non-diabetic patients with acute myocardial infarction. (24145196)
2013
13
Computed tomographic and magnetic resonance abnormalities of basal ganglion secondary to nonketotic hyperglycemia in a patient with stroke. (23909980)
2013
14
Hemichorea-hemiballism associated with hyperglycemia and a developmental venous anomaly. (24062343)
2013
15
Hyperbaric oxygen preconditioning attenuates hyperglycemia-enhanced hemorrhagic transformation by inhibiting matrix metalloproteinases in focal cerebral ischemia in rats. (23537951)
2013
16
TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction. (23607427)
2013
17
Hyperglycemia Is Associated With Corrected QT Prolongation and Mortality in Acutely Ill Patients. (23364575)
2013
18
Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats. (23250335)
2013
19
The manner of the inflammation-boosting effect caused by acute hyperglycemia secondary to overfeeding and the effects of insulin therapy in a rat model of sepsis. (23932353)
2013
20
Positive correlation between chronic hyperglycemia and serum fetuin-A levels in middle-aged and elderly Chinese. (23190703)
2012
21
Incidence of extreme hyperglycemia and hypoglycemia in hospitalized patients during the month of July in teaching hospitals. (23882363)
2012
22
High mortality associated with hyperglycemia, neutrophilia, and lymphopenia in critically ill patients. (22353790)
2012
23
Perioperative hypoglycemia in patients with diabetes: incidence after low normal fasting preoperative blood glucose versus after hyperglycemia treated with insulin. (23248826)
2012
24
N-acetylcysteine inhibits hyperglycemia-induced oxidative stress and apoptosis markers in diabetic neuropathy. (19840221)
2010
25
Hyperglycemia suppresses ABCA1 expression in vascular smooth muscle cells. (20101560)
2010
26
Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort. (20299486)
2010
27
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase. (19539448)
2009
28
Transient hyperglycemia during childhood acute lymphocytic leukemia chemotherapy: an old event revisited. (19701154)
2009
29
The effect of acute hyperglycemia on retinal thickness and ocular refraction in healthy subjects. (18219490)
2008
30
Type B lactic acidosis and insulin-resistant hyperglycemia in an adolescent following cardiac surgery. (18477905)
2008
31
Hyperglycemia impairs isoflurane-induced adenosine triphosphate-sensitive potassium channel activation in vascular smooth muscle cells. (18292430)
2008
32
Nateglinide improves postprandial hyperglycemia and insulin secretion in renal transplant recipients. (17425753)
2007
33
Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. (17040956)
2007
34
Hyperglycemia-induced thioredoxin-interacting protein expression differs in breast cancer-derived cells and regulates paclitaxel IC50. (17575238)
2007
35
Inhibitory effect of ketamine on phosphorylation of the extracellular signal-regulated kinase 1/2 following brain ischemia and reperfusion in rats with hyperglycemia. (17870450)
2007
36
Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis. (17761203)
2007
37
Hyperglycemia increases the levels of vascular cellular adhesion molecule-1 and monocyte-chemoattractant-protein-1 in the diabetic endothelial cell. (17618604)
2007
38
Glucokinase mutations in young children with hyperglycemia. (16444761)
2006
39
Hyperglycemia increased brain ischemia injury through extracellular signal-regulated protein Kinase. (16343798)
2006
40
Co-occurrence of seizure and chorea in a patient with nonketotic hyperglycemia. (16401900)
2005
41
Acute hyperglycemia alters von Willebrand factor but not the fibrinolytic system in elderly subjects with normal or impaired glucose tolerance. (15613917)
2004
42
Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes. (12706936)
2003
43
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. (11756336)
2002
44
Diarrhea associated with enteral feeding: hyperglycemia and other factors]. (9711312)
1998
45
Relative hyperproinsulinemia of NIDDM persists despite the reduction of hyperglycemia with insulin or sulfonylurea therapy. (9313749)
1997
46
Role of superoxide anions in changes of endothelial vasoactive response during acute hyperglycemia. (9497899)
1997
47
Glutathione reverses systemic hemodynamic changes induced by acute hyperglycemia in healthy subjects. (7611393)
1995
48
Pituitary response to growth hormone-releasing hormone in IDDM. Abnormal responses to insulin and hyperglycemia. (1727733)
1992
49
Increased glucose metabolism by enzyme-loaded erythrocytes in vitro and in vivo normalization of hyperglycemia in diabetic mice. (1586460)
1992
50
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. (3285132)
1988

Genetic Variations for Hyperglycemia

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Expression for genes affiliated with Hyperglycemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperglycemia

Search GEO for disease gene expression data for Hyperglycemia.

Pathways for genes affiliated with Hyperglycemia

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3GCG, GCGR, GCK, PDP1, AKR1B1, DDOST
2
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11.1PAX4, INS, MAFA, IAPP, PDX1, GCK
311.0GCG, GCK, PDX1, GIP, INS
4
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11.0GIP, NTSR1, IAPP, GCGR, GCG
5
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10.9GCK, PDX1, MAFA, INS
6
Hide members
10.9GCG, GCGR, IAPP, GIP
710.9INS, PCK2, PDX1, GCG
810.8INS, PDX1, GCK
910.8INS, IAPP, PDX1
1010.8AKR1B1, GLO1, PCK2
11
Hide members
10.8GCG, GIP, INS
1210.8INS, IAPP, GCG
13
Hide members
10.8GCG, GCGR, INS
14
Hide members
10.7GIP, GCG

Compounds for genes affiliated with Hyperglycemia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Hyperglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1glucose4412.8AHSP, IAPP, GCG, GCK, PDP1, PDX1
2lipid4411.9PCK2, GCG, GCK, INS, IAPP, NTSR1
3lactate4411.8AKR1B1, IAPP, PDP1, GCK, GLO1, PCK2
4arginine4411.8GCK, AKR1B1, SLC5A2, INS, GCG, IAPP
5alanine4411.8GCG, GCK, PCK2, PDP1, GIP, GLO1
6atp44 2812.7GLO1, GCK, PCK2, AHSP, FN3K, PDP1
7incretin4411.7PDX1, IAPP, GCGR, GIP, GCG, INS
8streptozotocin4411.7IAPP, PDX1, AKR1B1, GCK, GCG, INS
9epinephrine44 11 2413.7INS, GIP, IAPP, AKR1B1, PDP1, GCGR
10glycogen44 2412.7IAPP, GCGR, GCK, PDP1, PCK2, INS
11creatinine4411.7GCK, GLO1, INS, GIP, GCG, AKR1B1
12adenylate4411.7GCK, AKR1B1, GIP, GLO1, IAPP, GCGR
13sulfonylurea4411.6GCK, PDX1, IAPP, GIP, INS, GCG
14c-peptide4411.6INS, GIP, GCK, GCG, PDX1, IAPP
15i-app4411.5IAPP, PDX1, GCG, INS, GCK
16glutamine4411.5PDP1, GCK, GCG, AKR1B1, GLO1, PCK2
17fatty acid4411.5GCGR, GCG, GCK, INS, PDP1, PCK2
18fructose44 1112.5GCG, GCGR, AKR1B1, PCK2, GCK
19cysteine4411.4AKR1B1, IAPP, GCK, GCG, GLO1, AHSP
20cyclic amp44 2412.4IAPP, GCGR, GCG, GIP, PCK2, AHSP
21carbohydrates4411.4PDP1, GCG, GLO1, INS, GCK
22glycerol44 11 2413.4INS, AKR1B1, GCK, GCG, PCK2
23liraglutide44 28 1113.4GCG, IAPP, GIP, INS
24sitagliptin44 1112.4GCG, INS, GIP, IAPP
25repaglinide44 49 1113.3PAX4, INS, IAPP, GCG
26proglucagon4411.3PDX1, GCK, GIP, GCG
27indomethacin44 59 28 1114.3AHSP, GLO1, IAPP, AKR1B1, GCG
28katp4411.3INS, GCG, GCK, PDX1
29acetylcholine44 49 28 11 2415.3GCG, PDP1, UNC13B, IAPP, AHSP
30nicotinamide44 1112.3INS, GCG, PDX1, AKR1B1
31metformin44 49 1113.3GCK, GCG, IAPP, INS
32wortmannin4411.2INS, PCK2, PDX1, GIP, GCG
33exenatide44 1112.2INS, IAPP, GCG
34preproinsulin4411.2PDX1, GCK, INS
35glyceraldehyde44 2412.2AKR1B1, GCK, GLO1
36acarbose44 1112.2INS, GCG, IAPP
37fructosamine44 2412.2FN3K, INS, IAPP
38pramlintide44 1112.2GCG, INS, IAPP
39ibmx44 28 5913.1INS, PCK2, IAPP, GCG
40miglitol44 59 1113.1INS, IAPP, GCG
41forskolin44 49 1113.0IAPP, GCG, GCK, GIP, PDX1
42tolbutamide44 49 28 1114.0INS, GCK, GCG
43voglibose44 1112.0GCG, INS
44phenylglyoxal4410.9GLO1, AKR1B1
45norepinephrine44 11 2412.9AHSP
46meglitinide4410.8GCG, INS
47chromium picolinate4410.8INS, GCK
48hbig4410.7INS, AKR1B1
49vildagliptin44 1111.6INS, GCG
50aicar44 11 2412.5INS, PCK2, GCK

GO Terms for genes affiliated with Hyperglycemia

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16Gene Ontology
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Cellular components related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.8INS, GIP, GCG

Biological processes related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1endocrine pancreas developmentGO:03101811.4PAX4, INS, GIP, IAPP, PDX1, GCK
2small molecule metabolic processGO:04428111.4GCG, GCGR, GCK, PDP1, AKR1B1, PCK2
3carbohydrate metabolic processGO:00597511.2GCK, AKR1B1, GLO1, PCK2, SLC5A2
4regulation of insulin secretionGO:05079611.2GCG, GCK, GIP, INS
5glucose homeostasisGO:04259311.2GCGR, GCK, PDX1, INS
6positive regulation of insulin secretionGO:03202411.0GIP, PDX1, GCK
7detection of glucoseGO:05159410.9GCK, PDX1
8negative regulation of gluconeogenesisGO:04572110.9INS, GCK
9energy reserve metabolic processGO:00611210.8INS, GCGR, GCG
10positive regulation of glycolysisGO:04582110.8GCK, INS
11nitric oxide mediated signal transductionGO:00726310.7MAFA, PDX1
12positive regulation of glycogen biosynthetic processGO:04572510.6GCK, INS
13glucose metabolic processGO:00600610.5INS, PCK2, PDX1

Molecular functions related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.9INS, GIP, IAPP, GCG

Products for genes affiliated with Hyperglycemia

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  • Antibodies
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Sources for Hyperglycemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet