MCID: HYP066
MIFTS: 61

Hyperglycemia malady

Metabolic diseases category

Summaries for Hyperglycemia

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MedlinePlus:33 Hyperglycemia means high blood sugar or glucose. glucose comes from the foods you eat. insulin is a hormone that moves glucose into your cells to give them energy. hyperglycemia happens when your body doesn't make enough insulin or can't use it the right way. people with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. other problems that can raise blood sugar include infections, certain medicines, hormone imbalances, or severe illnesses.

MalaCards based summary: Hyperglycemia is related to ischemia and gestational diabetes. An important gene associated with Hyperglycemia is UNC13B (unc-13 homolog B (C. elegans)), and among its related pathways are G alpha (s) signalling events and Selected targets of HNF1. The drugs insulin and insulin, aspart, human and the compounds hbig and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include endothelial, kidney and liver, and related mouse phenotypes are normal and renal/urinary system.

Wikipedia:64 Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglyc more...

Aliases & Classifications for Hyperglycemia

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Hyperglycemia, Aliases & Descriptions:

Name: Hyperglycemia 9 11 44 33 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:4195
MeSH34 D006943
NCIt39 C26797

Related Diseases for Hyperglycemia

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Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.6MLN, AHSP, AKR1B1, PDP1, GCK
2gestational diabetes30.6INS, IAPP, GCK
3type 1 diabetes mellitus30.6INS, GCK
4permanent neonatal diabetes mellitus30.5GCK, INS
5diabetic nephropathy30.5INS, IAPP, AKR1B1
6diabetic neuropathy30.4INS, AKR1B1
7glucose intolerance30.4MLN, SLC5A2
8vascular disease30.4AHSP, INS, AKR1B1
9hyperinsulinism30.3GCK, GIP, INS
10hyperuricemia30.0INS, GCK
11insulin resistance29.9INS, GIP, IAPP, PCK2, PDP1, GCGR
12metabolic syndrome x29.8INS, IAPP, AKR1B1, GCK
13pancreatic cancer29.8PDX1, NTSR1, IAPP, INS
14maturity-onset diabetes of the young29.8INS, PDX1, GCK
15hypercholesterolemia29.8AHSP, INS, PDX1
16obesity29.7MLN, INS, GIP, IAPP, AKR1B1, PDP1
17hypoglycemia29.5MLN, INS, GIP, IAPP, AKR1B1, PCK2
18insulinoma29.5INS, IAPP, MAFA, PDX1, GCK
19diabetes mellitus29.1PCK2, AKR1B1, IAPP, GIP, TXNIP, INS
20type 2 diabetes mellitus28.9INS, SLC5A2, GCK, GCGR, PDP1, PDX1
21endotheliitis10.7
22pancreatitis10.6
23diabetic autonomic neuropathy10.5AKR1B1
24hepatitis10.5
25familial hyperinsulinism10.5GCK
26cerebritis10.4
27retinitis10.4
28myocardial infarction10.4
29atherosclerosis10.4
30pancreatic agenesis10.4PDX1
31leukemia10.3
32hypertension10.3
33diabetic ketoacidosis10.3
34dumping syndrome10.3MLN, GIP
35hyperinsulinemic hypoglycemia10.2GCK, INS
36acute lymphocytic leukemia10.2
37hypertriglyceridemia10.2
38blindness10.2
39acute myocardial infarction10.2
40diabetic retinopathy10.2
41neuronitis10.2
42chorea10.2
43hypoxia10.2
44sepsis10.2
45cushing's syndrome10.2GIP, INS
46familial combined hyperlipidemia10.2INS, TXNIP
47gastroparesis10.2MLN, INS
48hypokalemia10.1
49metabolic acidosis10.1
50breast cancer10.1

Graphical network of the top 20 diseases related to Hyperglycemia:



Diseases related to hyperglycemia

Symptoms for Hyperglycemia

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Genetic Tests for Hyperglycemia

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Anatomical Context for Hyperglycemia

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MalaCards organs/tissues related to Hyperglycemia:

32
Endothelial, Kidney, Liver, Brain, Heart, Smooth muscle, Skeletal muscle, Monocytes, Adipocyte, Lung, Breast, Prostate, Testes, Pancreatic islet, Bone, Ovary, Bone marrow, Retina, Pancreas, Thyroid, Pituitary, Neutrophil, Eye, Thymus, Cortex, Spinal cord, Myeloid, Prefrontal cortex, Dorsal root ganglion, Fetal liver, Fetal brain

Animal Models for Hyperglycemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperglycemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9TXNIP, NTSR1, MAFA, PDX1, GCGR, INS
2MP:00053677.6FN3K, INS, TXNIP, AKR1B1, MAFA, PDX1
3MP:00053766.4SLC5A2, FN3K, INS, TXNIP, GIP, IAPP
4MP:00053786.4INS, TXNIP, GIP, IAPP, AKR1B1, NTSR1

Publications for Hyperglycemia

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Articles related to Hyperglycemia:

(show top 50)    (show all 1070)
idTitleAuthorsYear
1
In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography. (25380667)
2014
2
Chorea-ballism associated with ketotic hyperglycemia. (25262066)
2014
3
Hyperhomocysteinemia and hyperglycemia induce and potentiate endothelial dysfunction via I1-calpain activation. (25352635)
2014
4
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men. (24026559)
2013
5
GALNT2 expression is reduced in patients with Type 2 diabetes: possible role of hyperglycemia. (23894607)
2013
6
Mild fasting hyperglycemia shifts fuel reliance toward fat during exercise in adults with impaired glucose tolerance. (23599396)
2013
7
Comment on: Draznin et al. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care 2013;36:1807-1814. (24265388)
2013
8
Hyperglycemia, insulin resistance, impaired pancreatic I^-cell function, and risk of pancreatic cancer. (23847240)
2013
9
Hyperglycemia induces altered expressions of angiogenesis associated molecules in the trophoblast. (23983782)
2013
10
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
11
Stress hyperglycemia in acute ST-segment elevation myocardial infarction is a marker of left ventricular remodeling. (23738623)
2013
12
Surge in regulatory cells does not prevent onset of hyperglycemia in NOD mice. (24328490)
2013
13
The possible mechanisms underlying the impairment of HIF-1I+ pathway signaling in hyperglycemia and the beneficial effects of certain therapies. (23983604)
2013
14
Maternal testosterone levels are associated with C-peptide levels in the Mexican American subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study cohort. (23757120)
2013
15
Insulin sensitivity, but not hyperglycemia, may be superior as a prognostic marker and therapeutic target for diabetes in heart failure. (22964377)
2012
16
Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses. (22931303)
2012
17
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
18
Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)/calmodulin-dependent kinase II in retinal capillary endothelial cells. (23049237)
2012
19
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
20
Hypo- and hyperglycemia in relation to the mean, standard deviation, coefficient of variation, and nature of the glucose distribution. (22953755)
2012
21
Mild hyperglycemia, but not glucagon-like peptide 1 predicts poor outcome after injury. (23231933)
2012
22
Positive correlation between chronic hyperglycemia and serum fetuin-A levels in middle-aged and elderly Chinese. (23190703)
2012
23
I+-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral I+-glucosidase inhibitor for improving postprandial hyperglycemia. (23106358)
2012
24
Hyperthyroidism presenting with hyperglycemia in an adolescent female. (21823542)
2011
25
Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. (20501596)
2010
26
Increased secretion of IP-10 from monocytes under hyperglycemia is via the TLR2 and TLR4 pathway. (19447045)
2009
27
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. (19074137)
2009
28
Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia. (19536400)
2009
29
Relationships between PON1 L55M polymorphism and coronary heart diseases complicated with fasting hyperglycemia in Han populations in Guangdong]. (19292048)
2009
30
Intensive insulin therapy in non-diabetic patients with myocardial infarction and hyperglycemia. INSUCOR study]. (18482525)
2008
31
Unexplained hyperglycemia in continuous subcutaneous insulin infusion: evaluation and treatment. (18375782)
2008
32
Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. (17955498)
2008
33
Refractive properties of the healthy human eye during acute hyperglycemia. (18389272)
2008
34
Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants. (18035140)
2007
35
Hyperglycemia induced oxidative stress in type-1 and type-2 diabetic patients with and without nephropathy. (17543235)
2007
36
Nateglinide improves postprandial hyperglycemia and insulin secretion in renal transplant recipients. (17425753)
2007
37
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. (15572028)
2005
38
Gender differences in renal responses to hyperglycemia and angiotensin-converting enzyme inhibition in diabetes. (16164648)
2005
39
Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. (18220582)
2005
40
Acute hyperglycemia alters von Willebrand factor but not the fibrinolytic system in elderly subjects with normal or impaired glucose tolerance. (15613917)
2004
41
Hyperglycemia downregulates total lipoprotein lipase activity in humans. (14984315)
2004
42
The effect of hyperglycemia on experimental retinal ischemia. (15006850)
2004
43
Hyperglycemia as a cardiovascular risk factor. (14678859)
2003
44
Human obesity and thinness, hyperlipidemia, hyperglycemia, and insulin resistance associated with HIV1 protease inhibitors. Prevention by alternating several antiproteases in short sequences. (10665336)
1999
45
Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. (9846581)
1998
46
Effect of induced hyperglycemia on contrast sensitivity function in insulin-dependent diabetic patients]. (7780272)
1995
47
Effects of hyperglycemia on interdigestive gastrointestinal motility in humans. (7886397)
1994
48
Low dose streptozotocin-induced diabetes in mice: reduced IL-2 production and modulation of streptozotocin-induced hyperglycemia by IL-2. (1428358)
1992
49
Hyperglycemia and toxic oil syndrome in Spain. (2060456)
1991
50
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. (2123890)
1990

Variations for Hyperglycemia

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Expression for genes affiliated with Hyperglycemia

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Expression patterns in normal tissues for genes affiliated with Hyperglycemia

Search GEO for disease gene expression data for Hyperglycemia.

Pathways for genes affiliated with Hyperglycemia

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Pathways related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GIP, IAPP, GCGR
29.6PDX1, IAPP, INS
39.6INS, PDX1, GCK
4
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.5PCK2, PDP1, GCK
5
Show member pathways
9.3INS, GIP, PDX1, GCK
69.3PDX1, PCK2, INS
7
Show member pathways
9.0INS, MAFA, PDX1, GCK
8
Show member pathways
8.8INS, IAPP, MAFA, PDX1, GCK
9
Show member pathways
8.8GCK, PDX1, MAFA, IAPP, INS
10
Show member pathways
8.4GCGR, NTSR1, IAPP, GIP, MLN
11
Show member pathways
8.2DDOST, INS, AKR1B1, PCK2, PDP1, GCGR

Compounds for genes affiliated with Hyperglycemia

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Sources:
44Novoseek, 25HMDB, 12DrugBank, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Hyperglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1hbig4410.3AKR1B1, INS
2Sorbitol2510.3AKR1B1, GCK
3chromium picolinate4410.3INS, GCK
4glyceraldehyde44 2511.3GCK, AKR1B1
5exenatide44 1211.2INS, IAPP
6alpha lipoic acid4410.1INS, AKR1B1, PDP1
7liraglutide44 29 1212.1INS, GIP, IAPP
8sitagliptin44 1211.1INS, GIP, IAPP
9fructosamine44 2511.0FN3K, INS, IAPP
10proglucagon4410.0PDX1, GCK, GIP
11preproinsulin4410.0GCK, PDX1, INS
12metformin44 50 1212.0GCK, IAPP, INS
13nicotinamide44 1210.9INS, AKR1B1, PDX1
14katp449.9PDX1, GCK, INS
15acarbose44 1210.8INS, IAPP
16glycerol 3-phosphate44 2510.8PCK2, GCK, PDP1
17i-app449.8PDX1, GCK, IAPP, INS
18aicar44 25 1211.8GCK, INS, PCK2
19norepinephrine44 25 1211.7AKR1B1, IAPP, AHSP, INS
20pramlintide44 1210.6INS, IAPP
21carnitine449.6PDP1, PCK2, INS
22glucose 6-phosphate44 2510.6FN3K, GCK, PCK2
23fructose44 1210.5GCK, GCGR, PCK2, AKR1B1
24glycerol44 25 1211.5AKR1B1, INS, PCK2, GCK
25creatinine449.5INS, AKR1B1, IAPP, GIP, GCK
26sulfonylurea449.5GCK, PDX1, INS, GIP, IAPP
27c-peptide449.5INS, IAPP, GCK, GIP, PDX1
28pyruvate449.5GCK, PCK2, PDP1, PDX1
29forskolin44 50 1211.4PDX1, GCK, IAPP, GIP
30epinephrine44 25 1211.3GIP, GCGR, AKR1B1, IAPP, INS, PDP1
31acetylcholine44 50 29 25 1213.2PDP1, MLN, AHSP, UNC13B, IAPP
32fatty acid449.2GCK, PCK2, PDP1, GCGR, INS
33lactate449.1INS, IAPP, AKR1B1, PCK2, GCK, PDP1
34incretin449.1GCK, GCGR, GIP, PDX1, IAPP, INS
35cyclic amp44 2510.1PCK2, GCGR, GIP, AHSP, IAPP
36streptozotocin449.1PCK2, IAPP, GCK, INS, AKR1B1, PDX1
37thymidine44 2510.0PDX1, PCK2, IAPP, GIP, NTSR1
38wortmannin449.0INS, PCK2, GIP, PDX1
39glycogen44 2510.0GCGR, PDP1, IAPP, PCK2, INS, GCK
40histamine44 29 2510.9IAPP, MLN, AHSP, GCGR
41oligonucleotide448.8GCK, GCGR, IAPP, PCK2, PDX1
42atp44 299.7FN3K, IAPP, PCK2, PDP1, GCGR, GCK
43adenylate448.7AKR1B1, IAPP, GIP, MLN, GCGR, GCK
44arginine448.4GCK, AKR1B1, IAPP, GIP, INS, AHSP
45serine448.3MLN, GCK, PDP1, PDX1, INS, AKR1B1
46alanine448.3GCK, PDP1, MLN, INS, GIP, AKR1B1
47lipid448.0INS, NTSR1, AHSP, GIP, IAPP, PCK2
48cholesterol44 29 25 1210.9GCK, PCK2, IAPP, TXNIP, INS, MLN
49calcium44 50 25 1210.5GCK, MLN, NTSR1, AHSP, UNC13B, GIP
50glucose444.7GCK, GIP, IAPP, AKR1B1, PCK2, MAFA

GO Terms for genes affiliated with Hyperglycemia

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Cellular components related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.9GIP, INS

Biological processes related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1detection of glucoseGO:05159410.2GCK, PDX1
2negative regulation of gluconeogenesisGO:04572110.1INS, GCK
3positive regulation of glycolytic processGO:04582110.1GCK, INS
4positive regulation of glycogen biosynthetic processGO:04572510.1GCK, INS
5glucose transportGO:0157589.9INS, GCK, SLC5A2
6regulation of insulin secretionGO:0507969.9GCK, GIP, INS
7response to starvationGO:0425949.8GCGR, GIP
8nitric oxide mediated signal transductionGO:0072639.7MAFA, PDX1
9pyruvate metabolic processGO:0060909.6PDP1, PCK2
10glucose homeostasisGO:0425939.5INS, PDX1, GCGR, GCK
11carbohydrate metabolic processGO:0059759.5AKR1B1, PCK2, GCK, SLC5A2
12glucose metabolic processGO:0060069.4PDX1, PCK2, INS
13positive regulation of insulin secretionGO:0320249.4GIP, PCK2, PDX1, GCK
14endocrine pancreas developmentGO:0310189.4GCK, PDX1, IAPP, GIP, INS
15response to glucoseGO:0097499.3MAFA, GIP, TXNIP
16insulin secretionGO:0300739.3PDX1, MAFA
17small molecule metabolic processGO:0442818.6INS, AKR1B1, PCK2, PDP1, GCGR, GCK

Molecular functions related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.8IAPP, GIP, INS, MLN

Products for genes affiliated with Hyperglycemia

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Sources for Hyperglycemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet