Hyperglycemia malady

Wikipedia: Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia, not to be confused...⁴⁴ more...

MalaCards: Hyperglycemia, also known as hyperglycemia (context-dependent category), is related to diabetes mellitus and pancreatitis. An important gene associated with Hyperglycemia is UNC13B (unc-13 homolog B (C. elegans)), and among its related pathways are Adipocytokines & Insulin Signaling and Development_Leptin signaling via PI3K-dependent pathway. The drugs insulin,nph,pork/purified and insulin,ultralente,human and the compounds lipid and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Aliases & Descriptions:

hyperglycemia 6 8 32 43 hyperglycemia (context-dependent category) 6

hyperglycemia (disorder) 6 hyperglycaemia 6

Diseases related to hyperglycemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 840)

id	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus	39.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
2	pancreatitis	36.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
3	type 1 diabetes mellitus	36.0	PIK3CG, RETN, GCK, GCG, NAGLU, LPA
4	hypoglycemia	34.7	PIK3CG, PCK2, PCK1, GCKR, GCK, GCG
5	insulin resistance	34.7	LEPR, UCP2, IRS1, INS, PTPN1, PPARGC1A
6	obesity	34.7	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, COG2
7	gestational diabetes	34.4	RETN, GCK, GCG, NAMPT, KCNJ11, LEP
8	type 2 diabetes mellitus	34.2	PIK3R1, PIK3C2A, COG2, RETN, CNR1, VWF
9	maturity-onset diabetes of the young	31.9	PCK2, PCK1, GCKR, GCK, GCG, PAX4
10	hypertriglyceridemia	31.8	COG2, GCKR, SELE, SELP, SERPINE1, NAMPT
11	vascular disease	31.4	RETN, VWF, VTN, SELE, SELP, SERPINC1
12	hyperinsulinism	31.2	RETN, GCKR, GCK, GCG, SELE, SERPINE1
13	ischemia	31.2	PIK3CA, PIK3C2A, PIK3CG, COG2, RETN, SGK1
14	breast cancer	30.3	PIK3CA, SGK1, BMP6, CDK2, IRS1, IRS2
15	carcinoma	30.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
16	glucose intolerance	29.8	GCG, MLN, APOA4, APOB, CCK, GHRL
17	polycystic ovary syndrome	29.7	LEP, IRS1, IRS2, INS, INSR, IGFBP1
18	hyperlipidemia	29.7	PIK3CB, PIK3C2A, PIK3CG, COG2, RETN, VWF
19	nephropathy	29.4	COG2, RETN, SGK1, CNDP1, VWF, VTN
20	atherosclerosis	29.3	PIK3C2A, PIK3CG, COG2, RETN, CNR1, VWF
21	sepsis	29.0	RETN, VTN, SELE, SELP, SERPINC1, SERPINE1
22	hepatitis	28.9	SELP, SERPINA1, ARG1, GSR, GPT, IFNB1
23	lactic acidosis	28.7	PIK3C2A, PIK3CG, PCK2, NAGLU, FASN, MAPK14
24	cerebritis	28.7	PIK3R1, PIK3C2A, PIK3CG, COG2, SGK1, CNR1
25	proteinuria	28.6	PIK3C2A, COG2, VWF, VTN, SELP, SERPINC1
26	acromegaly	28.3	RETN, GCG, SERPINC1, SERPINE1, NAGLU, NAMPT
27	pancreatic cancer	28.0	GCG, VEGFA, BIRC5, SCT, CDK2, MEN1
28	prostatitis	28.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
29	hypertension	27.9	PIK3CB, PIK3R1, PIK3C2A, PIK3CG, SH2B3, COG2
30	transient cerebral ischemia	27.8	BAD, XIAP, JUN, FOS, GSR, HSPA5
31	hypoxia	27.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
32	choriocarcinoma	27.6	PIK3CB, PIK3CG, RETN, BDNF, LEP, LEPR
33	thyroiditis	27.0	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, COG2
34	retinitis	27.0	PIK3CA, PIK3C2A, PIK3CG, PDE2A, SGK1, CNR1
35	essential hypertension	26.9	COG2, RETN, SGK1, VWF, GCK, GCGR
36	diabetic neuropathy	26.8	CNR1, VWF, VEGFA, PARP1, LEP, UCP1
37	colorectal cancer	26.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, COG2
38	brain ischemia	26.7	SELP, VEGFA, PARP1, BDNF, P4HB, XBP1
39	myocardial infarction	26.7	PIK3C2A, PIK3CG, SH2B3, COG2, RETN, CNR1
40	peritonitis	26.2	PIK3C2A, COG2, PDE2A, SGK1, VWF, VTN
41	fibrosis	25.7	PIK3CA, PIK3CG, RETN, SGK1, CNR1, VWF
42	coronary heart disease	24.9	PIK3C2A, COG2, RETN, CNDP1, VWF, GCKR
43	polyneuropathy	24.8	VEGFA, BMP6, PARP1, SCT, S100A8, B2M
44	celiac disease	24.8	SH2B3, SELE, BGLAP, KCNJ11, SCT, LEP
45	septic shock	24.8	PIK3C2A, SELE, SERPINC1, SERPINE1, AVP, FGA
46	congestive heart failure	24.6	PIK3C2A, PIK3CG, RETN, VWF, SELE, SELP
47	neuropathy	24.1	PIK3C2A, RETN, CNR1, VWF, GCG, SELE
48	diarrhea	23.6	VWF, GCG, SERPINA1, VEGFA, KCNJ11, SCT
49	prostate carcinoma	22.5	PIK3R1, PIK3CG, CNR1, VTN, GCLC, SELP
50	cystic fibrosis	21.6	PIK3CG, SGK1, VWF, GCLC, SELP, SERPINC1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 insulin, insulin,aspart,human/rdna, insulin,detemir,human, insulin,glargine,human/rdna, insulin,glulisine,human, insulin,lente,beef, insulin,lente,beef/pork, insulin,lente,beef/purified, insulin,lente,human/rdna, insulin,lente,human/semisynthetic, insulin,lente,pork/purified, insulin,lispro,human/rdna, insulin,lispro,protamine/rdna, insulin,nph,beef, insulin,nph,beef/pork, insulin,nph,beef/purified, insulin,nph,human/rdna, insulin,nph,human/semisynthetic, insulin,nph,pork/purified, insulin,protamine zinc,beef/pork, insulin,protamine zinc,beef/purified, insulin,protamine zinc,pork/purified, insulin,regular,beef/pork, insulin,regular,beef/purified, insulin,regular,human buffered, insulin,regular,human/rdna, insulin,regular,human/semisynthetic, insulin,regular,pork, insulin,regular,pork/purified, insulin,semilente,beef, insulin,semilente,beef/pork, insulin,semilente,pork/purified, insulin,ultralente,beef, insulin,ultralente,beef/pork, insulin,ultralente,beef/purified, insulin,ultralente,human, insulin,ultralente,human/rdna

MalaCards organs/tissues related to hyperglycemia:

²²

MGI Mouse Phenotypes related to hyperglycemia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	15.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
2	growth/size phenotype	MP:0005378	14.0	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, SGK1
3	mortality/aging	MP:0010768	13.1	PIK3CB, PIK3CA, PIK3C2A, PDE2A, CNR1, VWF
4	behavior/neurological phenotype	MP:0005386	12.7	PIK3CA, CNR1, PCK1, SELE, SELP, NAGLU
5	nervous system phenotype	MP:0003631	12.4	CNR1, VWF, SELP, SERPINC1, SERPINF1, NAGLU
6	respiratory system phenotype	MP:0005388	12.0	SELP, LPL, PARK2, PAX6, BDNF, LEPR
7	renal/urinary system phenotype	MP:0005367	11.9	SGK1, GCK, SELP, NAGLU, PAX6, LEPR
8	adipose tissue phenotype	MP:0005375	11.7	PIK3CA, PIK3R1, PIK3C2A, RETN, CNR1, PCK1
9	immune system phenotype	MP:0005387	11.5	PIK3CD, VWF, SELP, SETD7, NAGLU, PAX6
10	no phenotypic analysis	MP:0003012	11.5	PIK3CD, PIK3R1, SGK1, CNR1, PCK1, VEGFA
11	liver/biliary system phenotype	MP:0005370	11.4	RETN, PCK1, GCK, GCLC, SERPINC1, VEGFA
12	hematopoietic system phenotype	MP:0005397	11.4	SH2B3, RAB27A, CLIC1, LDHA, LCN2, BAD
13	normal phenotype	MP:0002873	11.3	PIK3R1, VTN, PCK1, GCLC, GCGR, SELE
14	endocrine/exocrine gland phenotype	MP:0005379	11.2	KDM1A, KCNJ11, UGDH, CD40LG, CDC25C, MEN1
15	other phenotype	MP:0005395	10.9	SH2B3, CNR1, ZFP57, LEPR, JAK2, CD40LG
16	craniofacial phenotype	MP:0005382	10.8	NAGLU, PAX6, BDNF, UGDH, FOXO1, INPPL1
17	integument phenotype	MP:0010771	10.8	PIK3CG, CNR1, PCK1, SELP, RAB27A, PARP1
18	embryogenesis phenotype	MP:0005380	10.6	PIK3CB, PIK3CA, GCLC, SERPINC1, BIRC5, PARP1
19	digestive/alimentary phenotype	MP:0005381	10.6	VWF, GCG, SERPINF1, VEGFA, PAX6, BDNF
20	limbs/digits/tail phenotype	MP:0005371	9.9	VEGFA, LEP, BAX, CD47, MMP9, FN1
21	skeleton phenotype	MP:0005390	9.7	PIK3CD, PIK3CG, CNR1, NAGLU, VEGFA, BMP6
22	muscle phenotype	MP:0005369	9.6	PIK3CA, PIK3R1, PIK3CG, VEGFA, LPL, PARK2
23	cellular phenotype	MP:0005384	9.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, SH2B3
24	reproductive system phenotype	MP:0005389	8.5	PIK3CA, GCGR, SERPINF1, VEGFA, LIPC, PAX6
25	vision/eye phenotype	MP:0005391	8.0	PIK3CA, SELE, SELP, SERPINC1, SERPINF1, NAGLU
26	tumorigenesis	MP:0002006	7.7	PIK3CB, PIK3CA, PIK3R1, SERPINE1, PAX6, LEP
27	cardiovascular system phenotype	MP:0005385	7.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, VWF

Articles related to hyperglycemia:

(show top 50)    (show all 401)

id	Title	Authors	Year	Affiliating Genes
1	O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation. (19944066)	Yang W.H.... Cho J.W.	2010	GPX1
2	Glucagon-like peptide-1 response to meals and post-pr andial hyperglycemia in Type 2 diabetic patients. (19783893)	Mannucci E.... Rotella C.M.	2010	GCG
3	C-reactive protein -717C>T genetic polymorphism as sociates with esophagectomy-induced stress hyperglycemia. (20145925)	Motoyama S.... Ogawa J.	2010	TGFB1, PPARG, TNF
4	Exogenous glucose-dependent insulinotropic polypeptid e worsens post prandial hyperglycemia in type 2 diabetes. (19276444)	Chia C.W.... Egan J.M.	2009	GCG, RETN
5	Serum vascular adhesion protein-1 is increased in acu te and chronic hyperglycemia. (19336232)	Li H.Y.... Chuang L.M.	2009	AOC3
6	Hyperglycemia induces a dynamic cooperativity of hist one methylase and demethylase enzymes associated with gene-activating epigeneti c marks that coexist on the lysine tail. (19208907)	Brasacchio D.... El-Osta A.	2009	SETD7, SUV39H1, KDM1A
7	Hyperglycemia regulates RUNX2 activation and cellular wound healing through the aldose reductase polyol pathway. (19383984)	D'Souza D.R.... Passaniti A.	2009	AKR1B1, IGF1, RUNX2
8	Rab34 and its effector munc13-2 constitute a new path way modulating protein secretion in the cellular response to hyperglycemia. (19641095)	Goldenberg N.M.... Silverman M.	2009	UNC13B, RAB34
9	GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells. (19103594)	Zhang L.... Volchuk A.	2009	P4HB, HSPA5, XBP1
10	Gastrodine represses expression of IL-1 beta, IL-6 i nduced by hyperglycemia in gitter cells (19777841)	Du X.... Shan Y.	2009	IL6
11	Relationships between PON1 L55M polymorphism and coronary heart diseases complicated with fasting hyperglycemia in Han populations in Guangdong (19292048)	Zhou H.... Tian H.M.	2009	PON1
12	The impact of admission hyperglycemia or hypoalbuminemia on need ventilator, time ventilated, mortality, and morbidity in critically ill trauma patients. (19353313)	Safavi M.... Honarmand A.	2009	ALB
13	Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. (17955498)	Manabe E.... Yoshikawa T.	2008	JUN, CCL2
14	Treating hyperglycemia and diabetes with insulin therapy: transition from inpatient to outpatient care. (19008977)	Lavernia F.	2008	INS
15	A comparison of efficacy and safety in the treatment of hyperglycemia with continuous subcutaneous insulin with insulin pump or multiple insulin injections daily in critical elderly patients (18786316)	Huang W.... Yang Y.	2008	CRP
16	Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination. (18338795)	Yu C.... Dobrowsky R.T.	2008	CAV1
17	Rapidly developing hyperglycemia during treatment wit h olanzapine. (18364401)	Kohen I.... Manu P.	2008	INS
18	Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. (18267070)	Chibalin A.V.... Zierath J.R.	2008	DGKD, INS, DGKE
19	Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy. (18556343)	Chen H.S.... Lin H.D.	2008	INS
20	Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231. (17555594)	Turturro F.... Welbourne T.	2007	TXN, TXNIP
21	Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. (17272778)	Kamada H.... Chan P.H.	2007	SOD1, MMP9
22	G protein-linked cell signaling and cardiovascular functions in diabetes/hyperglycemia. (16456234)	Hashim S.... Anand-Srivastava M.B.	2006	DYT10
23	Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. (16804411)	Shao J.... Chen Z.	2006	PTCH1, SMO
24	Reduced insulin and IGF-I signaling, not hyperglycemia, underlies the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach. (15855342)	HorvA!th V.J.... OrdAPg T.	2005	IGF1
25	Heme oxygenase overexpression attenuates glucose-mediated oxidative stress in quiescent cell phase: linking heme to hyperglycemia complications. (16181102)	Sacerdoti D.... Abraham N.G.	2005	HMOX1
26	Hyperglycemia downregulates total lipoprotein lipase activity in humans. (14984315)	Kovar J.... Poledne R.	2004	LPL, SST, LIPC
27	IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia. (15126010)	Suzuki H.... Yamada Y.	2004	INS
28	Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers. (12453975)	Stride A.... Hattersley A.T.	2002	HNF1A
29	Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene. (12460054)	Waller S.C.... Bingham C.	2002	HNF1B
30	Hyperglycemia-induced production of acute phase reactants in adipose tissue. (11546817)	Lin Y.... Scherer P.E.	2001	SAA3P
31	Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. (11600590)	Broglio F.... Ghigo E.	2001	GHRL
32	Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia. (10623607)	Sheibani N.... Frazier W.A.	2000	THBS1
33	Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study. (10634338)	Meigs J.B.... Wilson P.W.	2000	SERPINE1, INS
34	Prevalence and atherosclerosis risk in different type s of non-diabetic hyperglycemia. Is mild hyperglycemia an underestimated evil? (10826515)	Temelkova-Kurktschiev T.... Hanefeld M.	2000	INS
35	Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. (10318828)	Jonas J.C.... Weir G.C.	1999	LDHA, HK1, NME2
36	Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia. (10480597)	Mahalingam B.... Weber I.T.	1999	GCK
37	Sustained hyperglycemia in vitro down-regulates the GLUT1 glucose transport system of cultured human term placental trophoblast: a mechanism to protect fetal development? (9737725)	Hahn T.... Desoye G.	1998	SLC2A1
38	Hyperglycemia regulates the glucose-transport system of clonal choriocarcinoma cells in vitro. A potential molecular mechanism contributing to the adjunct effect of glucose in tumor therapy. (9766571)	Hahn T.... Desoye G.	1998	SLC2A1, SLC2A3
39	Effect of acute hyperglycemia on basal and bombesin-stimulated pancreaticobiliary secretion in humans. (9700954)	Lam W.F.... Lamers C.B.	1998	CCK, GRP
40	Modification of postprandial hyperglycemia with insul in lispro improves glucose control in patients with type 2 diabetes. (9314631)	Feinglos M.N.... Lane J.D.	1997	INS
41	Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia. (9166674)	Nikoulina S.E.... Henry R.R.	1997	AIR
42	Prediabetic markers in children with stress hyperglycemia. (8790124)	Bhisitkul D.M.... Maclaren N.K.	1996	INS
43	Hyperglycemia-induced changes in Na+/myo-inositol transport, Na(+)-K(+)-ATPase, and protein kinase C activity in proximal tubule cells. (7698515)	Cole J.A.... Yordy M.R.	1995	DYT10
44	Effects of recent, short-term hyperglycemia on responses to hypoglycemia in humans. Relevance to the pathogenesis of hypoglycemia unawareness and hyperglycemia-induced insulin resistance. (7729608)	Fanelli C.... Bolli G.B.	1995	INS
45	Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. (7635966)	Xia P.... King G.L.	1995	PLA2G2A, PLA2G4A, DYT10
46	Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. (7556948)	Sharma K.... Ziyadeh F.N.	1995	TGFB1
47	Stress-induced hyperglycemia and hypoinsulinemia are suppressed by sulfonylurea. Predominant role of insulin. (8640242)	Vargas L.... Kawada M.E.	1994	INS
48	A case of syndrome X whose hyperglycemia, hyperlipidemia and hypertension were improved as accompanying with decreased insulin resistance (7851834)	Hiramatsu S.... Nawata H.	1994	INS
49	Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus. (1727820)	Kahn S.E.... Porte D.	1992	INS
50	Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. (2123890)	Kelley D.E.... Mandarino L.J.	1990	PDP1

Genes related to hyperglycemia according to GeneCards:

(show top 50)    (show all 361)

id	Symbol	Description	Score	GeneCards Section Context
1	UNC13B	unc-13 homolog B (C. elegans)	11.1	Summaries, Publications
2	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	11.0	Publications, Summaries
3	DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase	11.0	Summaries
4	NTSR1	neurotensin receptor 1 (high affinity)	11.0	Summaries
5	AIR	Acute insulin response (2)	11.0	Publications
6	MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	11.0
7	PAX4	paired box 4	11.0
8	GLO1	glyoxalase I	11.0	Publications
9	SLC5A2	solute carrier family 5 (sodium/glucose cotransporter), member 2	11.0	Publications
10	TXNIP	thioredoxin interacting protein	11.0	Publications
11	FN3K	fructosamine 3 kinase	11.0
12	PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	11.0	Publications
13	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	11.0	Publications
14	SLC29A2	solute carrier family 29 (nucleoside transporters), member 2	11.0
15	IAPP	islet amyloid polypeptide	11.0	Publications
16	AHSP	alpha hemoglobin stabilizing protein	11.0	Publications
17	GIP	gastric inhibitory polypeptide	11.0	Publications
18	GCG	glucagon	11.0	Functions, Publications
19	GCK	glucokinase (hexokinase 4)	11.0	Publications
20	GCGR	glucagon receptor	11.0
21	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	11.0	Publications
22	GYS1	glycogen synthase 1 (muscle)	11.0	Publications
23	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0	Publications
24	MLN	motilin	11.0	Publications
25	KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4	11.0
26	SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	11.0	Publications
27	PDX1	pancreatic and duodenal homeobox 1	11.0	Publications
28	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0	Publications
29	ST3GAL4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	11.0	Publications
30	NEUROD1	neuronal differentiation 1	11.0
31	INS	insulin	11.0	Publications
32	SLC29A1	solute carrier family 29 (nucleoside transporters), member 1	11.0
33	GCKR	glucokinase (hexokinase 4) regulator	11.0
34	PTPRN	protein tyrosine phosphatase, receptor type, N	11.0
35	HNF1B	HNF1 homeobox B	11.0	Publications
36	G6PC	glucose-6-phosphatase, catalytic subunit	11.0	Publications
37	SCT	secretin	11.0	Publications
38	GHRH	growth hormone releasing hormone	11.0	Publications
39	HNF1A	HNF1 homeobox A	11.0	Publications
40	HMGB1	high mobility group box 1	11.0	Publications
41	SORD	sorbitol dehydrogenase	11.0	UniProt Related
42	APOA4	apolipoprotein A-IV	11.0	Publications
43	SIRPA	signal-regulatory protein alpha	11.0	Publications
44	DUSP1	dual specificity phosphatase 1	11.0	Publications
45	SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	11.0	Publications
46	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
47	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
48	ADRB3	adrenoceptor beta 3	11.0	Publications
49	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
50	IRS2	insulin receptor substrate 2	11.0	Publications

Pathways related to hyperglycemia according to GeneDecks:

(show top 50)    (show all 274)

id	Pathway	Score	Top Affiliating Genes
1	Adipocytokines & Insulin Signaling37	11.8	PIK3CB, PIK3CD, PIK3R1, PIK3CG, RETN, NAMPT
2	Development_Leptin signaling via PI3K-dependent pathway41	11.7	PIK3CB, PIK3CD, PIK3R1, KCNJ11, LEP, LEPR
3	Maturity onset diabetes of the young20	11.6	GCK, PAX4, PAX6, MAFA, IAPP, HNF1A
4	Selected targets of HNF110	11.5	SERPINA1, LPA, UCP2, INS, APOA1, APOB
5	Transcription Receptor-mediated HIF regulation10	11.2	PIK3CD, PIK3R1, IRS1, IRS2, INS, INSR
6	Development_Growth hormone signaling via PI3K/AKT and MAPK cascades41	11.1	PIK3R1, CEBPB, JUN, JAK2, FOS, IRS1
7	Development_Leptin signaling via JAK/STAT and MAPK cascades41	11.1	LEPR, JAK2, PTPN1, CYCS, PLA2G4A, SOCS3
8	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	11.0	PIK3CD, MAPK9, MAP3K5
9	Aldosterone-regulated sodium reabsorption20	10.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, SGK1, IRS2
10	Growth Hormone Signaling36	10.6	PIK3R1, CEBPB, JAK2, IRS1, MAPK8, MAPK3
11	Colorectal cancer20	10.6	PIK3CB, PIK3CD, PIK3R1, PIK3CG, BAD, FOS
12	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.5	LEP, LEPR, JAK2, MAPK3, PTPN1, CRP
13	Development IGF-RI signaling10	10.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, BAD, MTOR
14	Activation of PKA through GPCR36	10.5	PDE2A, GCG, GCGR, BMP6, BDNF, BAD
15	Development_Thrombopoietin-regulated cell processes41	10.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, BIRC5, BAD
16	Development_Prolactin receptor signaling41	10.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, CEBPB, JUN
17	Development Growth hormone signaling via PI3K/AKT and MAPK cascades10	10.3	PIK3CA, PIK3R1, MTOR, CEBPB, JUN, JAK2
18	Jak-STAT signaling pathway20	10.2	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LEP
19	Development VEGF signaling and activation10	10.2	PIK3CB, PIK3CD, PIK3CA, PIK3R1, SELE, VCAM1
20	Development_EGFR signaling pathway41	10.2	PIK3CB, PIK3CD, PIK3CA, PIK3R1, JUN, MMP9
21	TGF-beta Signaling Pathways37	9.9	PIK3CB, PIK3CD, PIK3R1, PIK3CG, MTOR, JUN
22	Focal adhesion20	9.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, VWF
23	Akt Signaling36	9.7	PIK3R1, PIK3CG, FOXO1, GYS1, GYS2, IRS1
24	Cellular Transformation by HTLV136	9.7	JUN, JAK2, FOS, MAPK8, MAPK10, MAPK9
25	Signal transduction PTEN pathway10	9.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, BAD, MTOR
26	p70S6K Signaling36	9.5	PIK3R1, BMP6, BDNF, BAD, JAK2, IRS1
27	Amoebiasis20	9.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, FN1, ARG1
28	Immune response MIF-mediated glucocorticoid regulation10	8.4	VCAM1, JUN, FOS, IL2, IL6, IL8
29	PGC1Alpha Pathway36	8.4	BMP6, BAX, INSR, IL12B, IL18, IL1A
30	Pathways in cancer20	8.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, VEGFA
31	T cell receptor signaling pathway20	8.2	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, JUN
32	Osteoclast differentiation20	8.2	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, JUN
33	African trypanosomiasis20	8.1	SELE, VCAM1, IL10, IL12B, IL18, IL1B
34	Toll-like receptor signaling pathway20	8.1	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, JUN
35	Immune response IL-1 signaling pathway10	8.0	SERPINE1, JUN, FOS, IL1A, IL1B, IL6
36	Immune response_IL-1 signaling pathway41	8.0	SERPINE1, JUN, FOS, IL1A, IL1B, IL6
37	Malaria20	7.9	SELE, SELP, VCAM1, CD36, CD40LG, IL10
38	Leishmaniasis20	7.8	JUN, JAK2, FOS, IL10, IL12B, IL1A
39	Antioxidant Action of Vitamin-C36	7.7	BMP6, BDNF, BAX, JUN, JAK2, FOS
40	Rho Family GTPases36	7.7	PIK3R1, BMP6, BDNF, BAX, JUN, FOS
41	Toxoplasmosis20	7.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, BAD
42	PEDF Induced Signaling36	7.6	SERPINF1, BMP6, BDNF, BAX, FOS, IL10
43	Influenza A20	7.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, JUN
44	Tec Kinases Signaling36	7.3	PIK3R1, BMP6, BDNF, BAX, JAK2, FOS
45	p38 Signaling36	7.2	BMP6, BDNF, BAX, CDC25C, INSR, FGF2
46	TGF-Beta Pathway36	7.2	PIK3R1, BMP6, BDNF, BAX, JUN, FOS
47	Chagas disease (American trypanosomiasis)20	7.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, SERPINE1
48	STAT3 Pathway36	7.0	BMP6, BAX, JAK2, IL10, IL12B, IL18
49	MAPK Family Pathway36	7.0	PIK3R1, BMP6, BDNF, BAX, JUN, FGF2
50	Glucocorticoid Receptor Signaling36	6.7	BMP6, BAX, CEBPB, JUN, FOS, IL10

Compounds related to hyperglycemia according to GeneDecks:

(show top 50)    (show all 544)

id	Compound	Score	Top Affiliating Genes
1	lipid32	18.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
2	estrogen32	13.7	PIK3CB, PIK3R1, COG2, RETN, VWF, GCG
3	h2o232	13.7	PIK3CB, PIK3R1, PIK3CG, SGK1, VWF, GCK
4	c-peptide32	13.3	RETN, GCK, GCG, NAGLU, KCNJ11, SCT
5	potassium32 9 18 9	16.1	PIK3CA, PIK3C2A, COG2, SGK1, VTN, GCK
6	palmitate32	12.6	GCG, SELE, UCP1, UCP2, UCP3, XBP1
7	phospholipid32	12.5	PIK3CB, PIK3R1, COG2, VWF, SERPINA1, LPL
8	p00332	12.2	COG2, RETN, SERPINA1, SERPINE1, LIPC, LEP
9	inositol32	12.1	PIK3CB, PIK3CD, LPL, BDNF, CDIPT, INPPL1
10	heparin32 9 18 9	15.1	PIK3CA, PIK3C2A, PIK3CG, COG2, VWF, VTN
11	sucrose32 9 18 9	15.0	GCK, GCG, SCARB1, UGDH, P4HB, CD59
12	incretin32	12.0	GCK, GCG, GCGR, INS, CCK, IAPP
13	forskolin32 42 9 9	14.8	PIK3R1, RETN, GCK, GCG, BMP6, BDNF
14	thiazolidinedione32	11.8	RETN, PCK2, SERPINE1, LPL, SCARB1, LEP
15	citrate32	11.7	PIK3C2A, GCK, SELP, NAGLU, UCP3, P4HB
16	orlistat32 42 9 9	14.7	CNR1, GCG, LPL, LIPC, LEP, INS
17	atropine32 9 9	13.5	GCG, SCT, MLN, GRP, CCK, GNAI1
18	dhea32	11.5	RETN, LEP, IRS2, INS, IGFBP1, IGFBP3
19	endotoxin32	11.5	RETN, PCK2, LEPR, S100A8, CEBPB, JAK2
20	glycerol 3-phosphate32 18	12.4	PCK2, PCK1, GCK, LPL, LEP, UGDH
21	thyroxine32 18	12.3	PIK3C2A, COG2, RETN, VWF, LPA, LPL
22	chloramphenicol32 9 9	13.3	SGK1, PCK2, SELE, SERPINC1, SERPINE1, LPL
23	pkcs32	11.3	PIK3CB, PIK3R1, PIK3CG, FOS, GRP, MAPK8
24	pravastatin32 34 9 18 9	15.1	PIK3C2A, COG2, SELE, SELP, SERPINE1, LPA
25	fluvastatin32 34 9 9	14.0	PIK3C2A, COG2, VWF, SELP, SERPINE1, LPL
26	alpha lipoic acid32	11.0	SERPINA1, VCAM1, BAX, P4HB, MMP9, INS
27	wortmannin32 42	12.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
28	apocynin32	11.0	SELE, VCAM1, MPO, JUN, JAK2, MAPK8
29	vegf32	10.9	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, RETN
30	folate32	10.8	VWF, SELE, SERPINC1, LPA, VCAM1, B2M
31	cyclophosphamide32 34 9 9	13.8	NPPB
32	vitamin b1232	10.7	VWF, LPA, B2M, MPO, CD40LG, APOA1
33	betacarotene32	10.6	VWF, LPL, SCARB1, LEP, CETP, GSR
34	phorbol32	10.5	JUN, CDK2, MMP9, FOS, FN1, GRP
35	etoposide32 42 9 9	13.1	PIK3CB, PIK3CA, PIK3R1, PIK3CG, SELE, BIRC5
36	retinoid32	10.0	PCK2, BMP6, UCP1, BAX, S100A8, CEBPB
37	dextran sulfate32	9.8	VTN, SELE, SELP, SERPINC1, LPL, CETP
38	sulfasalazine32 9 9	11.0	SELE, MPO, CD40LG, IL12B, IL1A, IL1B
39	resveratrol32 9 18 9	11.9	PIK3CA, PIK3CG, VEGFA, BIRC5, PARP1, BAX
40	methotrexate32 34 42 9 9	12.8	PIK3C2A, SELE, SERPINE1, NAGLU, BMP6, BIRC5
41	dexamethasone32 42 34 9 9	12.7	PIK3CA, PIK3R1, RETN, SGK1, VWF, VTN
42	parthenolide32	8.6	PIK3CG, JAK2, MMP9, IL6, IL8, MAPK8
43	paclitaxel32 34 9 9	11.5	PIK3CA, PIK3CG, VEGFA, BMP6, BIRC5, PARP1
44	butyrate32	8.5	GCK, GCG, BMP6, BIRC5, LEP, BAX
45	quercetin32 42 9 18 9	12.1	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
46	simvastatin32 34 42 9 18 9	12.9	PIK3C2A, COG2, VWF, SELE, SELP, SERPINE1
47	infliximab32 9 9	8.9	SELE, VEGFA, BGLAP, FGF2, IL10, IL18
48	pdtc32	6.6	PIK3CA, PIK3CG, GCLC, SELE, VCAM1, BIRC5
49	gm-csf32	6.4	VEGFA, BMP6, IL10, IL18, IL1A, IL1B
50	15-deoxy-delta-12,14-prostaglandin j232	6.4	PIK3CG, SERPINE1, VEGFA, VCAM1, BMP6, BIRC5

Cellular components related to hyperglycemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	13.1	F7, HLA-DRB1, TPO, TNF, TNFRSF1A, TNFRSF1B
2	caveola	GO:005901	10.8	SLC2A1, NOS3, SMO, PTCH1, HMOX1, CAV1
3	extracellular region	GO:005576	10.5	IL6R, IFNB1, IFNG, F7, IAPP, ALB
4	cytosol	GO:005829	10.5	HK1, ROCK1, ADCY10, GAPDH, GAD2, NME2
5	cell surface	GO:009986	10.4	CAV1, GHR, GHSR, HMGB1, TPO, TNF
6	platelet alpha granule lumen	GO:031093	9.9	IGF1, ALB, PLG, THBS1, FGA, FN1
7	cytoplasm	GO:005737	9.8	SPHK1, PPIG, NR3C1, NRF1, SMG1, CREBBP
8	secretory granule	GO:030141	9.3	GHRL, PLAT, PLA2G2A, THBS1, POMC, CPE
9	external side of plasma membrane	GO:009897	8.2	ICAM1, HLA-DRB1, TNF, CTLA4, ACE, TLR2
10	extracellular space	GO:005615	7.9	ANGPT2, ALB, HSPG2, HP, AKR1B1, GH1

Biological processes related to hyperglycemia according to GeneDecks:

(show top 50)    (show all 69)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	14.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
2	carbohydrate metabolic process	GO:005975	13.3	PCK2, PCK1, GCKR, GCK, NAGLU, GYS1
3	glucose homeostasis	GO:042593	12.5	PCK1, GCK, SERPINE1, PAX6, BAD, IRS1
4	energy reserve metabolic process	GO:006112	12.1	GCG, GCGR, KCNJ11, LEP, LEPR, INS
5	cellular response to insulin stimulus	GO:032869	12.1	GCK, PARP1, IRS1, IRS2, INSR, FBP1
6	response to glucose stimulus	GO:009749	12.0	GYS2, IRS2, INSR, ANGPT2, MAFA, MAPK14
7	endocrine pancreas development	GO:031018	11.8	GCK, PAX4, FOXO1, INS, IL6, IL6R
8	lipoprotein metabolic process	GO:042157	11.4	LPA, LPL, SCARB1, P4HB, CETP, APOA1
9	lipid metabolic process	GO:006629	11.4	LPA, LPL, SCARB1, UCP3, P4HB, CETP
10	glucose metabolic process	GO:006006	11.4	PIK3CA, PCK2, PCK1, KCNJ11, LEP, GYS1
11	response to organic cyclic compound	GO:014070	11.1	SELP, SERPINA1, JUN, IL1A, IL1RN, IL4
12	glucose transport	GO:015758	11.0	GCKR, GCK, INS, AKT1, GH1, EDN1
13	positive regulation of cell proliferation	GO:008284	11.0	NAMPT, VEGFA, BIRC5, LEP, AVP, JAK2
14	response to insulin stimulus	GO:032868	11.0	PCK1, LEP, UCP3, IRS1, INPPL1, IL10
15	innate immune response	GO:045087	11.0	PIK3CD, PIK3CG, LCN2, S100A12, JUN, FOS
16	positive regulation of inflammatory response	GO:050729	11.0	PDE2A, SERPINE1, JAK2, CD47, IL12B, IL18
17	response to nutrient	GO:007584	10.9	CNR1, GCGR, SERPINC1, VCAM1, UCP3, MTOR
18	response to lipopolysaccharide	GO:032496	10.8	CNR1, SELE, SELP, SERPINA1, S100A8, CEBPB
19	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.7	JAK2, IRS1, IRS2, MAPK3, MAPK1, GH1
20	insulin receptor signaling pathway	GO:008286	10.7	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, NAMPT, MTOR
21	signal transduction	GO:007165	10.7	PIK3CB, PIK3CD, GCG, NAMPT, CLIC1, UNC13B
22	response to drug	GO:042493	10.7	LPL, BGLAP, PAX4, BDNF, KCNJ11, XBP1
23	phosphatidylinositol-mediated signaling	GO:048015	10.7	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, BAD, MTOR
24	regulation of insulin secretion	GO:050796	10.6	CNR1, GCK, GCG, KCNJ11, LEP, INS
25	response to ethanol	GO:045471	10.6	CNR1, BGLAP, S100A8, AVP, MMP9, INSR
26	cholesterol metabolic process	GO:008203	10.5	LIPC, LEP, LEPR, CETP, IL4, APOA1
27	response to amino acid stimulus	GO:043200	10.5	MTOR, ARG1, CCL2, ICAM1, GIP, TNFRSF1A
28	positive regulation of protein kinase B signaling cascade	GO:051897	10.5	PIK3CG, MTOR, ARRB2, INS, INSR, GPX1
29	aging	GO:007568	10.4	CNR1, SERPINF1, VCAM1, UCP3, JUN, IL1B
30	positive regulation of apoptotic process	GO:043065	10.4	CNR1, BAD, BAX, JAK2, MMP9, MEN1
31	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.4	VTN, VEGFA, MTOR, JAK2, CD36, INS
32	blood coagulation	GO:007596	10.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, SH2B3, PDE2A
33	response to estradiol stimulus	GO:032355	10.3	SERPINA1, MMP9, INSR, IL1B, F3, GH1
34	response to glucocorticoid stimulus	GO:051384	10.2	PCK2, SERPINF1, SERPINE1, BGLAP, UCP3, INSR
35	platelet degranulation	GO:002576	10.0	VWF, SELP, SERPINA1, SERPINE1, VEGFA, CD36
36	leukocyte migration	GO:050900	10.0	PIK3CB, PIK3CA, PIK3R1, SELP, CD47, FN1
37	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.9	SGK1, JUN, FOS, MAPK8, MAPK3, MAPK14
38	negative regulation of apoptotic process	GO:043066	9.9	PIK3CG, GCG, SERPINE1, VEGFA, KDM1A, LEP
39	response to hypoxia	GO:001666	9.9	SERPINA1, VEGFA, VCAM1, LEP, UCP3, MMP9
40	angiogenesis	GO:001525	9.5	PIK3CA, PIK3CG, SERPINE1, VEGFA, JUN, FN1
41	negative regulation of cell proliferation	GO:008285	9.5	JUN, JAK2, CDKN3, INPPL1, FGF2, MEN1
42	MAPK cascade	GO:000165	9.4	INS, MEN1, IL18, IL1B, MAPK3, MAPK1
43	cellular response to lipopolysaccharide	GO:071222	9.3	SERPINE1, CD36, ARG1, IL10, IL12B, IL8
44	platelet activation	GO:030168	9.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, VWF, SELP
45	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	JAK2, INS, INSR, IL1B, IFNG, ICAM1
46	positive regulation of angiogenesis	GO:045766	9.2	SERPINE1, VEGFA, MMP9, FGF2, IL1A, IL1B
47	positive regulation of protein phosphorylation	GO:001934	8.9	VEGFA, MTOR, INSR, IL1B, MAPK3, CCND3
48	anti-apoptosis	GO:006916	8.9	PIK3CA, GCLC, BIRC5, BDNF, XIAP, CEBPB
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	SERPINE1, VEGFA, BMP6, PAX6, KDM1A, JUN
50	inflammatory response	GO:006954	8.4	PIK3CD, PIK3CG, SELE, SELP, BMP6, S100A12

Molecular functions related to hyperglycemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor binding	GO:005102	11.5	CAV1, HNF4A, PPY, NOS2, LTA, AGRP
2	protein binding	GO:005515	11.4	NPHS1, SOD1, OGT, PRKCA, PRKAB1, PRKAA2
3	hormone activity	GO:005179	11.4	ADIPOQ, LEP, SCT, GCG, RETN, MLN
4	insulin receptor binding	GO:005158	11.0	SHC1, PTPN1, IGF1, IGF1R, ENPP1, INS
5	protein homodimerization activity	GO:042803	10.7	PDE2A, VWF, ADIPOQ, ADRB3, PON1, SOD1
6	cytokine activity	GO:005125	6.4	IL6, IFNB1, IFNG, HMGB1, TNF, SPP1