MCID: HYP066
MIFTS: 62

Hyperglycemia malady

Metabolic diseases category
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Summaries for Hyperglycemia

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MedlinePlus:33 Hyperglycemia means high blood sugar or glucose. glucose comes from the foods you eat. insulin is a hormone that moves glucose into your cells to give them energy. hyperglycemia happens when your body doesn't make enough insulin or can't use it the right way. people with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. other problems that can raise blood sugar include infections, certain medicines, hormone imbalances, or severe illnesses.

MalaCards based summary: Hyperglycemia is related to ischemia and gestational diabetes. An important gene associated with Hyperglycemia is UNC13B (unc-13 homolog B (C. elegans)), and among its related pathways are G alpha (s) signalling events and Selected targets of HNF1. The drugs insulin and insulin, aspart, human and the compounds hbig and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include endothelial, kidney and liver, and related mouse phenotypes are normal and renal/urinary system.

Wikipedia:65 Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglyc more...

Aliases & Classifications for Hyperglycemia

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Hyperglycemia, Aliases & Descriptions:

Name: Hyperglycemia 8 10 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:4195
MeSH34 D006943
NCIt39 C26797

Related Diseases for Hyperglycemia

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Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.6MLN, GCK, PDP1, AKR1B1, AHSP
2gestational diabetes30.6IAPP, INS, GCK
3glucose intolerance30.6MLN, SLC5A2
4type 1 diabetes mellitus30.6INS, GCK
5permanent neonatal diabetes mellitus30.5GCK, INS
6diabetic nephropathy30.5AKR1B1, INS, IAPP
7diabetic neuropathy30.4AKR1B1, INS
8vascular disease30.4INS, AHSP, AKR1B1
9hyperinsulinism30.3GIP, GCK, INS
10insulin resistance29.9GIP, GCK, GCGR, PDP1, SLC5A2, INS
11metabolic syndrome x29.8IAPP, GCK, INS, AKR1B1
12pancreatic cancer29.8PDX1, NTSR1, IAPP, INS
13maturity-onset diabetes of the young29.8INS, PDX1, GCK
14hyperuricemia29.8GCK, INS
15hypercholesterolemia29.8INS, AHSP, PDX1
16obesity29.7GCK, GCGR, AKR1B1, GIP, INS, MLN
17hypoglycemia29.5GCK, MLN, INS, GIP, IAPP, AKR1B1
18insulinoma29.5GCK, INS, IAPP, MAFA, PDX1
19diabetes mellitus29.1GCK, GCGR, PDP1, PDX1, PCK2, AKR1B1
20type 2 diabetes mellitus28.8INS, GCGR, PDP1, PDX1, PCK2, AKR1B1
21endotheliitis10.7
22pancreatitis10.6
23diabetic autonomic neuropathy10.5AKR1B1
24hepatitis10.5
25familial hyperinsulinism10.5GCK
26cerebritis10.4
27retinitis10.4
28myocardial infarction10.4
29atherosclerosis10.4
30pancreatic agenesis10.4PDX1
31leukemia10.3
32hypertension10.3
33diabetic ketoacidosis10.3
34dumping syndrome10.3MLN, GIP
35hyperinsulinemic hypoglycemia10.2INS, GCK
36acute lymphocytic leukemia10.2
37hypertriglyceridemia10.2
38blindness10.2
39acute myocardial infarction10.2
40diabetic retinopathy10.2
41neuronitis10.2
42chorea10.2
43hypoxia10.2
44sepsis10.2
45cushing's syndrome10.2GIP, INS
46familial combined hyperlipidemia10.2TXNIP, INS
47gastroparesis10.2MLN, INS
48hypokalemia10.1
49metabolic acidosis10.1
50breast cancer10.1

Graphical network of the top 20 diseases related to Hyperglycemia:



Diseases related to hyperglycemia

Symptoms for Hyperglycemia

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Genetic Tests for Hyperglycemia

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Anatomical Context for Hyperglycemia

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MalaCards organs/tissues related to Hyperglycemia:

32
Endothelial, Kidney, Liver, Brain, Heart, Smooth muscle, Skeletal muscle, Monocytes, Adipocyte, Lung, Breast, Prostate, Testes, Pancreatic islet, Bone, Ovary, Bone marrow, Retina, Pancreas, Thyroid, Pituitary, Neutrophil, Eye, Thymus, Cortex, Spinal cord, Myeloid, Prefrontal cortex, Dorsal root ganglion, Fetal liver, Fetal brain

Animal Models for Hyperglycemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperglycemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9TXNIP, NTSR1, MAFA, PDX1, GCGR, INS
2MP:00053677.6FN3K, INS, TXNIP, AKR1B1, MAFA, PDX1
3MP:00053766.4SLC5A2, FN3K, INS, TXNIP, GIP, IAPP
4MP:00053786.4INS, TXNIP, GIP, IAPP, AKR1B1, NTSR1

Publications for Hyperglycemia

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Articles related to Hyperglycemia:

(show top 50)    (show all 1070)
idTitleAuthorsYear
1
In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography. (25380667)
2014
2
Chorea-ballism associated with ketotic hyperglycemia. (25262066)
2014
3
Hyperhomocysteinemia and hyperglycemia induce and potentiate endothelial dysfunction via I1-calpain activation. (25352635)
2014
4
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men. (24026559)
2013
5
GALNT2 expression is reduced in patients with Type 2 diabetes: possible role of hyperglycemia. (23894607)
2013
6
Mild fasting hyperglycemia shifts fuel reliance toward fat during exercise in adults with impaired glucose tolerance. (23599396)
2013
7
Comment on: Draznin et al. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care 2013;36:1807-1814. (24265388)
2013
8
Hyperglycemia, insulin resistance, impaired pancreatic I^-cell function, and risk of pancreatic cancer. (23847240)
2013
9
Hyperglycemia induces altered expressions of angiogenesis associated molecules in the trophoblast. (23983782)
2013
10
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
11
Stress hyperglycemia in acute ST-segment elevation myocardial infarction is a marker of left ventricular remodeling. (23738623)
2013
12
Surge in regulatory cells does not prevent onset of hyperglycemia in NOD mice. (24328490)
2013
13
The possible mechanisms underlying the impairment of HIF-1I+ pathway signaling in hyperglycemia and the beneficial effects of certain therapies. (23983604)
2013
14
Maternal testosterone levels are associated with C-peptide levels in the Mexican American subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study cohort. (23757120)
2013
15
Insulin sensitivity, but not hyperglycemia, may be superior as a prognostic marker and therapeutic target for diabetes in heart failure. (22964377)
2012
16
Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses. (22931303)
2012
17
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
18
Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)/calmodulin-dependent kinase II in retinal capillary endothelial cells. (23049237)
2012
19
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
20
Hypo- and hyperglycemia in relation to the mean, standard deviation, coefficient of variation, and nature of the glucose distribution. (22953755)
2012
21
Mild hyperglycemia, but not glucagon-like peptide 1 predicts poor outcome after injury. (23231933)
2012
22
Positive correlation between chronic hyperglycemia and serum fetuin-A levels in middle-aged and elderly Chinese. (23190703)
2012
23
I+-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral I+-glucosidase inhibitor for improving postprandial hyperglycemia. (23106358)
2012
24
Hyperthyroidism presenting with hyperglycemia in an adolescent female. (21823542)
2011
25
Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. (20501596)
2010
26
Increased secretion of IP-10 from monocytes under hyperglycemia is via the TLR2 and TLR4 pathway. (19447045)
2009
27
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. (19074137)
2009
28
Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia. (19536400)
2009
29
Relationships between PON1 L55M polymorphism and coronary heart diseases complicated with fasting hyperglycemia in Han populations in Guangdong]. (19292048)
2009
30
Intensive insulin therapy in non-diabetic patients with myocardial infarction and hyperglycemia. INSUCOR study]. (18482525)
2008
31
Unexplained hyperglycemia in continuous subcutaneous insulin infusion: evaluation and treatment. (18375782)
2008
32
Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. (17955498)
2008
33
Refractive properties of the healthy human eye during acute hyperglycemia. (18389272)
2008
34
Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants. (18035140)
2007
35
Hyperglycemia induced oxidative stress in type-1 and type-2 diabetic patients with and without nephropathy. (17543235)
2007
36
Nateglinide improves postprandial hyperglycemia and insulin secretion in renal transplant recipients. (17425753)
2007
37
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. (15572028)
2005
38
Gender differences in renal responses to hyperglycemia and angiotensin-converting enzyme inhibition in diabetes. (16164648)
2005
39
Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. (18220582)
2005
40
Acute hyperglycemia alters von Willebrand factor but not the fibrinolytic system in elderly subjects with normal or impaired glucose tolerance. (15613917)
2004
41
Hyperglycemia downregulates total lipoprotein lipase activity in humans. (14984315)
2004
42
The effect of hyperglycemia on experimental retinal ischemia. (15006850)
2004
43
Hyperglycemia as a cardiovascular risk factor. (14678859)
2003
44
Human obesity and thinness, hyperlipidemia, hyperglycemia, and insulin resistance associated with HIV1 protease inhibitors. Prevention by alternating several antiproteases in short sequences. (10665336)
1999
45
Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. (9846581)
1998
46
Effect of induced hyperglycemia on contrast sensitivity function in insulin-dependent diabetic patients]. (7780272)
1995
47
Effects of hyperglycemia on interdigestive gastrointestinal motility in humans. (7886397)
1994
48
Low dose streptozotocin-induced diabetes in mice: reduced IL-2 production and modulation of streptozotocin-induced hyperglycemia by IL-2. (1428358)
1992
49
Hyperglycemia and toxic oil syndrome in Spain. (2060456)
1991
50
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. (2123890)
1990

Variations for Hyperglycemia

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Expression for genes affiliated with Hyperglycemia

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Expression patterns in normal tissues for genes affiliated with Hyperglycemia

Search GEO for disease gene expression data for Hyperglycemia.

Pathways for genes affiliated with Hyperglycemia

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Pathways related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GIP, IAPP, GCGR
29.6PDX1, IAPP, INS
39.6INS, PDX1, GCK
4
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.5PCK2, PDP1, GCK
5
Show member pathways
9.3INS, GIP, PDX1, GCK
69.3PDX1, PCK2, INS
7
Show member pathways
9.0INS, MAFA, PDX1, GCK
8
Show member pathways
8.8INS, IAPP, MAFA, PDX1, GCK
9
Show member pathways
8.8GCK, PDX1, MAFA, IAPP, INS
10
Show member pathways
8.4GCGR, NTSR1, IAPP, GIP, MLN
11
Show member pathways
8.2DDOST, INS, AKR1B1, PCK2, PDP1, GCGR

Compounds for genes affiliated with Hyperglycemia

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 50PharmGKB
See all sources

Compounds related to Hyperglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1hbig4410.3INS, AKR1B1
2Sorbitol2410.3AKR1B1, GCK
3glyceraldehyde44 2411.3GCK, AKR1B1
4chromium picolinate4410.2INS, GCK
5exenatide44 1111.2INS, IAPP
6alpha lipoic acid4410.1INS, AKR1B1, PDP1
7liraglutide44 28 1112.1IAPP, GIP, INS
8sitagliptin44 1111.1INS, GIP, IAPP
9fructosamine44 2411.0FN3K, INS, IAPP
10proglucagon4410.0GCK, PDX1, GIP
11preproinsulin4410.0GCK, PDX1, INS
12metformin44 50 1112.0GCK, IAPP, INS
13nicotinamide44 1110.9PDX1, AKR1B1, INS
14katp449.9INS, PDX1, GCK
15acarbose44 1110.8INS, IAPP
16glycerol 3-phosphate44 2410.8GCK, PDP1, PCK2
17i-app449.8GCK, PDX1, IAPP, INS
18aicar44 24 1111.8GCK, PCK2, INS
19norepinephrine44 24 1111.7AKR1B1, IAPP, INS, AHSP
20pramlintide44 1110.6IAPP, INS
21carnitine449.6INS, PCK2, PDP1
22glucose 6-phosphate44 2410.6FN3K, PCK2, GCK
23fructose44 1110.5AKR1B1, PCK2, GCGR, GCK
24glycerol44 24 1111.5GCK, PCK2, AKR1B1, INS
25creatinine449.5INS, GIP, IAPP, AKR1B1, GCK
26sulfonylurea449.5INS, GIP, IAPP, PDX1, GCK
27c-peptide449.5INS, GIP, IAPP, PDX1, GCK
28pyruvate449.5PCK2, PDX1, PDP1, GCK
29forskolin44 50 1111.4GCK, PDX1, IAPP, GIP
30epinephrine44 24 1111.3INS, GIP, IAPP, AKR1B1, PDP1, GCGR
31acetylcholine44 50 28 24 1113.2PDP1, IAPP, UNC13B, AHSP, MLN
32fatty acid449.2INS, PCK2, PDP1, GCGR, GCK
33lactate449.1INS, IAPP, AKR1B1, PCK2, PDP1, GCK
34incretin449.1INS, GIP, IAPP, PDX1, GCGR, GCK
35cyclic amp44 2410.1AHSP, GIP, IAPP, PCK2, GCGR
36streptozotocin449.1INS, IAPP, AKR1B1, PCK2, PDX1, GCK
37thymidine44 2410.0GIP, IAPP, NTSR1, PCK2, PDX1
38wortmannin449.0PDX1, PCK2, GIP, INS
39glycogen44 2410.0INS, IAPP, PCK2, PDP1, GCGR, GCK
40histamine44 28 2410.9GCGR, IAPP, AHSP, MLN
41oligonucleotide448.8IAPP, PCK2, PDX1, GCGR, GCK
42atp44 289.7FN3K, AHSP, IAPP, PCK2, PDP1, GCGR
43adenylate448.7MLN, GIP, IAPP, AKR1B1, GCGR, GCK
44arginine448.4MLN, AHSP, INS, GIP, IAPP, AKR1B1
45serine448.3MLN, INS, IAPP, AKR1B1, PDX1, PDP1
46alanine448.3MLN, INS, GIP, AKR1B1, PCK2, PDP1
47lipid448.0AHSP, INS, TXNIP, GIP, IAPP, NTSR1
48cholesterol44 28 24 1110.9MLN, AHSP, INS, TXNIP, IAPP, PCK2
49calcium44 50 24 1110.5MLN, AHSP, UNC13B, GIP, IAPP, NTSR1
50glucose444.7SLC5A2, AIR, FN3K, MLN, AHSP, INS

GO Terms for genes affiliated with Hyperglycemia

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Cellular components related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.9GIP, INS

Biological processes related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1detection of glucoseGO:05159410.2GCK, PDX1
2negative regulation of gluconeogenesisGO:04572110.1INS, GCK
3positive regulation of glycolytic processGO:04582110.1GCK, INS
4positive regulation of glycogen biosynthetic processGO:04572510.1GCK, INS
5glucose transportGO:0157589.9INS, GCK, SLC5A2
6regulation of insulin secretionGO:0507969.9GCK, GIP, INS
7response to starvationGO:0425949.8GCGR, GIP
8nitric oxide mediated signal transductionGO:0072639.7MAFA, PDX1
9pyruvate metabolic processGO:0060909.6PDP1, PCK2
10glucose homeostasisGO:0425939.5INS, PDX1, GCGR, GCK
11carbohydrate metabolic processGO:0059759.5AKR1B1, PCK2, GCK, SLC5A2
12glucose metabolic processGO:0060069.4PDX1, PCK2, INS
13positive regulation of insulin secretionGO:0320249.4GIP, PCK2, PDX1, GCK
14endocrine pancreas developmentGO:0310189.4GCK, PDX1, IAPP, GIP, INS
15response to glucoseGO:0097499.3MAFA, GIP, TXNIP
16insulin secretionGO:0300739.3PDX1, MAFA
17small molecule metabolic processGO:0442818.6INS, AKR1B1, PCK2, PDP1, GCGR, GCK

Molecular functions related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.8IAPP, GIP, INS, MLN

Products for genes affiliated with Hyperglycemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hyperglycemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet