MCID: HYP066
MIFTS: 59

Hyperglycemia malady

Summaries for Hyperglycemia

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Hyperglycemia means high blood sugar or glucose. glucose comes from the foods you eat. insulin is a hormone that moves glucose into your cells to give them energy. hyperglycemia happens when your body doesn't make enough insulin or can't use it the right way. people with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. other problems that can raise blood sugar include infections, certain medicines, hormone imbalances, or severe illnesses.

MalaCards: Hyperglycemia, also known as hyperglycaemia, is related to insulin resistance and hypoglycemia. An important gene associated with Hyperglycemia is UNC13B (unc-13 homolog B (C. elegans)), and among its related pathways are Metabolism and Regulation of beta-cell development. The drugs insulin and insulin, aspart, human and the compounds glucose and lipid have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and homeostasis/metabolism.

Wikipedia:64 Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia, not to be confused... more...

Aliases & Classifications for Hyperglycemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Related Diseases for Hyperglycemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.0GCG, GCGR, GCK, PDP1, IAPP, GIP
2hypoglycemia30.8GCG, GCGR, GCK, AKR1B1, IAPP, GIP
3glucose intolerance30.4GCG, GCGR, GCK, IAPP, INS
4gestational diabetes30.3INS, IAPP, GCK, GCG
5type 1 diabetes30.3GCG, GCK, PDX1, AKR1B1, IAPP, GLO1
6diabetic nephropathy30.2INS, IAPP, AKR1B1
7vascular disease30.2GCG
8hyperinsulinism30.1INS, GIP, GCK, GCG
9coronary artery disease,30.1GCG, AKR1B1, AHSP, INS
10permanent neonatal diabetes mellitus30.1GCK, INS
11autonomic neuropathy29.9GCG, AKR1B1, INS
12diabetic autonomic neuropathy29.9AKR1B1
13insulinoma29.7GCG, GCK, PDX1, IAPP, MAFA, INS
14hypercholesterolemia29.7INS, AHSP, PDX1
15atherosclerosis10.3
16n syndrome10.3
17acute myocardial infarction10.3
18diabetic ketoacidosis10.3
19acute leukemia10.3
20hypertriglyceridemia10.2
21acute lymphocytic leukemia10.2
22hypoxia10.2
23brain ischemia10.2
24stroke, ischemic10.1
25hypokalemia10.1
26metabolic acidosis10.1
27chorea10.1
28sepsis10.1
29hemorrhage, intracerebral10.1
30diabetic embryopathy10.1
31acute myocarditis10.1
32diabetic polyneuropathy10.1
33transient cerebral ischemia10.1
34fasting hypoglycemia10.1
35pancreatitis, chronic10.1
36diabetes, type 210.1
37diabetes mellitus, noninsulin-dependent10.1
38mody, type ii10.1
39hyperopia10.1
40type 2 diabetes mellitus10.0GCG, SLC5A2, PAX4, INS, PCK2, GCGR
41diabetes mellitus10.0GCG, GCGR, GCK, PDP1, PDX1, AKR1B1
42obesity10.0GCG, GCGR, GCK, PDP1, AKR1B1, IAPP
43metabolic syndrome x10.0INS, IAPP, AKR1B1, GCK, GCG
44ischemia10.0GCG, GCK, PDP1, AKR1B1, AHSP
45maturity-onset diabetes of the young10.0GCK, PDX1, INS, PAX4
46hyperinsulinemic hypoglycemia10.0INS, GCK, GCG
47essential hypertension10.0INS, AHSP, IAPP, GCGR
48myocardial infarction10.0AHSP, AKR1B1, PDX1, GCG
49neonatal diabetes mellitus10.0INS, PDX1, GCK
50pancreatitis10.0INS, GCG

Graphical network of the top 20 diseases related to Hyperglycemia:



Diseases related to hyperglycemia

Clinical Features for Hyperglycemia

Genetic Tests for Hyperglycemia

Anatomical Context for Hyperglycemia

Animal Models for Hyperglycemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hyperglycemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.8PAX4, GCG, GCGR, GCK, PDX1, AKR1B1
2MP:000537611.5AKR1B1, PDX1, GCK, GCGR, GCG, IAPP
3MP:000536711.3GCG, GCK, PDX1, AKR1B1, FN3K, MAFA
4MP:000537911.3GCGR, GCK, PDX1, MAFA, INS, PAX4

Publications for Hyperglycemia

Sources:
51PubMed
See all sources

Articles related to Hyperglycemia:

(show top 50)    (show all 1047)
idTitleAuthorsYear
1
Chronic fatigue in type 1 diabetes: highly prevalent but not explained by hyperglycemia or glucose variability. (23949561)
2014
2
Low circulating level of IGF-1 is a distinct indicator for the development of cardiovascular disease caused by combined hyperglycemia and dyslipidemia. (24345340)
2014
3
Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. (24373672)
2013
4
Poly(lactic-co-glycolic) acid loaded nano-insulin has greater potentials of combating arsenic induced hyperglycemia in mice: some novel findings. (23276653)
2013
5
Does hyperglycemia in pregnancy change fetal kidney growth?: a longitudinal prospective study. (24337055)
2013
6
Stiffness memory of EA.hy926 endothelial cells in response to chronic hyperglycemia. (23806077)
2013
7
Incident hyperglycemia, parenteral nutrition administration and adverse outcomes in patients with myeloma admitted for initial auto-SCT. (23419432)
2013
8
AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: a "glycoxidation-centric" point of view. (23786818)
2013
9
Prevalence of hyperglycemia among adults with newly diagnosed HIV/AIDS in China. (23394285)
2013
10
Hyperglycemia in stroke and possible treatments. (23622737)
2013
11
AKAP150 Contributes to Enhanced Vascular Tone by Facilitating BKCa Channel Remodeling in Hyperglycemia and Diabetes. (24323672)
2013
12
Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study. (23880198)
2013
13
D-saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-I_B and PKC signaling. (23261973)
2013
14
Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. (23593240)
2013
15
Prognostic value of stress hyperglycemia for in-hospital outcome in acute coronary artery disease. (23503821)
2013
16
Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. (23782941)
2013
17
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia. (24239482)
2013
18
A.S.P.E.N. Clinical Guidelines: hyperglycemia and hypoglycemia in the neonate receiving parenteral nutrition. (22179520)
2012
19
Changes in the treatment of inpatient hyperglycemia: what every nurse practitioner should know about the 2012 standards of care. (23190125)
2012
20
Increase in Insulin Secretion Induced by Panax ginseng Berry Extracts Contributes to the Amelioration of Hyperglycemia in Streptozotocininduced Diabetic Mice. (23717115)
2012
21
Inhibition of fatty acid translocase cluster determinant 36 (CD36), stimulated by hyperglycemia, prevents glucotoxicity in INS-1 cells. (22430143)
2012
22
NF-I_Ba89inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. (22581287)
2012
23
Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats. (23075723)
2012
24
Acetylcholinesterase (AChE) is an important link in the apoptotic pathway induced by hyperglycemia in Y79 retinoblastoma cell line. (22685426)
2012
25
Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. (20974729)
2011
26
Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia. (19238311)
2010
27
Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model. (19487929)
2009
28
The impact of admission hyperglycemia or hypoalbuminemia on need ventilator, time ventilated, mortality, and morbidity in critically ill trauma patients. (19353313)
2009
29
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. (19208907)
2009
30
Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia. (19190104)
2009
31
Insulin therapy to improve BMI in cystic fibrosis-related diabetes without fasting hyperglycemia: results of the cystic fibrosis related diabetes therapy trial. (19592632)
2009
32
Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. (17955498)
2008
33
Oral infection, hyperglycemia, and endothelial dysfunction. (17905606)
2008
34
Hyperglycemia and lipopolysaccharide decrease depression effect of interleukin 8 production by hypothermia: an experimental study with endothelial cells. (17898993)
2008
35
Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia. (17925336)
2008
36
Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants. (18035140)
2007
37
Factor VIIa and tissue factor procoagulant activity in diabetes mellitus after acute ischemic stroke: impact of hyperglycemia. (18000605)
2007
38
Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice. (16223491)
2005
39
C-reactive protein and tumor necrosis factor-alpha in gestational hyperglycemia. (16370555)
2005
40
Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion. (15228952)
2004
41
Glucose clearance is delayed after hyperglycemia in healthy elderly men. (12840207)
2003
42
In vitro reversal of hyperglycemia normalizes insulin action in fat cells from type 2 diabetes patients: is cellular insulin resistance caused by glucotoxicity in vivo? (12601640)
2003
43
Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and -independent pathways. (10837498)
2000
44
Chronic sulfonylurea treatment and hyperglycemia aggravate disproportionately elevated plasma proinsulin levels in patients with type 2 diabetes. (11228051)
2000
45
Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression. (10893317)
2000
46
Influence of hyperglycemia and hyperuricemia on long-term transplant survival in kidney transplant recipients. (10515217)
1999
47
Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. (9846581)
1998
48
Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. (8826967)
1996
49
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. (8433729)
1993
50
Protein C deficiency in insulin-dependent diabetes: a hyperglycemia-related phenomenon. (2274914)
1990

Genetic Variations for Hyperglycemia

Expression for genes affiliated with Hyperglycemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperglycemia

Search GEO for disease gene expression data for Hyperglycemia.

Pathways for genes affiliated with Hyperglycemia

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3GCG, GCGR, GCK, PDP1, AKR1B1, DDOST
2
Hide members
11.1PAX4, INS, MAFA, IAPP, PDX1, GCK
311.0GCG, GCK, PDX1, GIP, INS
4
Hide members
11.0GIP, NTSR1, IAPP, GCGR, GCG
5
Hide members
10.9GCK, PDX1, MAFA, INS
6
Hide members
10.9GCG, GCGR, IAPP, GIP
710.9INS, PCK2, PDX1, GCG
810.8INS, PDX1, GCK
910.8INS, IAPP, PDX1
1010.8AKR1B1, GLO1, PCK2
11
Hide members
10.8GCG, GIP, INS
1210.8INS, IAPP, GCG
13
Hide members
10.8GCG, GCGR, INS
14
Hide members
10.7GIP, GCG

Compounds for genes affiliated with Hyperglycemia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Hyperglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1glucose4512.8PAX4, GCK, GCGR, GCG, PDP1, PDX1
2lipid4511.9GCG, GCK, IAPP, NTSR1, GIP, GLO1
3lactate4511.8GCG, GCK, PDP1, AKR1B1, IAPP, GLO1
4arginine4511.8GCG, GCK, AKR1B1, IAPP, GIP, AHSP
5alanine4511.8GCG, GCK, PDP1, AKR1B1, GIP, GLO1
6atp45 2912.7GCGR, GCK, PDP1, IAPP, FN3K, GLO1
7incretin4511.7INS, GIP, IAPP, PDX1, GCK, GCGR
8streptozotocin4511.7GCG, GCK, PDX1, AKR1B1, IAPP, PCK2
9epinephrine45 11 2413.7GCG, GCGR, PDP1, AKR1B1, IAPP, GIP
10glycogen45 2412.7GCG, GCGR, GCK, PDP1, IAPP, PCK2
11creatinine4511.7GCG, GCK, AKR1B1, IAPP, GIP, GLO1
12adenylate4511.7GCG, GCGR, GCK, AKR1B1, IAPP, GIP
13sulfonylurea4511.6GCG, GCK, PDX1, IAPP, GIP, INS
14c-peptide4511.6GCG, GCK, PDX1, IAPP, GIP, INS
15i-app4511.5GCG, GCK, PDX1, IAPP, INS
16glutamine4511.5GCG, GCK, PDP1, AKR1B1, GLO1, PCK2
17fatty acid4511.5GCG, GCGR, GCK, PDP1, PCK2, INS
18fructose45 1112.5GCG, GCGR, GCK, AKR1B1, PCK2
19cysteine4511.4GCG, GCK, AKR1B1, IAPP, GLO1, PCK2
20cyclic amp45 2412.4GCG, GCGR, IAPP, GIP, PCK2, AHSP
21carbohydrates4511.4GCG, GCK, PDP1, GLO1, INS
22glycerol45 11 2413.4GCG, GCK, AKR1B1, PCK2, INS
23liraglutide45 29 1113.4INS, GIP, IAPP, GCG
24sitagliptin45 1112.4GCG, IAPP, GIP, INS
25repaglinide45 50 1113.3GCG, IAPP, INS, PAX4
26proglucagon4511.3GIP, PDX1, GCK, GCG
27indomethacin45 60 29 1114.3GCG, AKR1B1, IAPP, GLO1, AHSP
28katp4511.3GCG, GCK, PDX1, INS
29acetylcholine45 50 29 11 2415.3GCG, PDP1, UNC13B, IAPP, AHSP
30nicotinamide45 1112.3GCG, PDX1, AKR1B1, INS
31metformin45 50 1113.3GCG, GCK, IAPP, INS
32wortmannin4511.2GCG, PDX1, GIP, PCK2, INS
33exenatide45 1112.2INS, IAPP, GCG
34preproinsulin4511.2GCK, PDX1, INS
35glyceraldehyde45 2412.2GCK, AKR1B1, GLO1
36acarbose45 1112.2INS, IAPP, GCG
37pramlintide45 1112.2GCG, IAPP, INS
38fructosamine45 2412.2IAPP, FN3K, INS
39ibmx45 29 6013.1INS, PCK2, IAPP, GCG
40miglitol45 60 1113.1INS, IAPP, GCG
41forskolin45 50 1113.0GIP, IAPP, PDX1, GCK, GCG
42tolbutamide45 50 29 1114.0GCG, GCK, INS
43phenylglyoxal4511.0AKR1B1, GLO1
44voglibose45 1111.9GCG, INS
45norepinephrine45 11 2412.9AHSP
46vildagliptin45 1111.8GCG, INS
47chromium picolinate4510.8GCK, INS
48hbig4510.7AKR1B1, INS
49meglitinide4510.6GCG, INS
50aicar45 11 2412.5GCK, PCK2, INS

GO Terms for genes affiliated with Hyperglycemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.8INS, GIP, GCG

Biological processes related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1endocrine pancreas developmentGO:03101811.4PAX4, INS, GIP, IAPP, PDX1, GCK
2small molecule metabolic processGO:04428111.4GCG, GCGR, GCK, PDP1, AKR1B1, PCK2
3carbohydrate metabolic processGO:00597511.2GCK, AKR1B1, GLO1, PCK2, SLC5A2
4regulation of insulin secretionGO:05079611.2GCG, GCK, GIP, INS
5glucose homeostasisGO:04259311.2GCGR, GCK, PDX1, INS
6positive regulation of insulin secretionGO:03202411.0GIP, PDX1, GCK
7detection of glucoseGO:05159410.9GCK, PDX1
8negative regulation of gluconeogenesisGO:04572110.9INS, GCK
9energy reserve metabolic processGO:00611210.8INS, GCGR, GCG
10positive regulation of glycolysisGO:04582110.8GCK, INS
11nitric oxide mediated signal transductionGO:00726310.7MAFA, PDX1
12positive regulation of glycogen biosynthetic processGO:04572510.6GCK, INS
13glucose metabolic processGO:00600610.5INS, PCK2, PDX1

Molecular functions related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.9INS, GIP, IAPP, GCG

Products for genes affiliated with Hyperglycemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperglycemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet