MCID: HYP066
MIFTS: 65

Hyperglycemia malady

Summaries for Hyperglycemia

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Hyperglycemia means high blood sugar or glucose. glucose comes from the foods you eat. insulin is a hormone that moves glucose into your cells to give them energy. hyperglycemia happens when your body doesn't make enough insulin or can't use it the right way. people with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. other problems that can raise blood sugar include infections, certain medicines, hormone imbalances, or severe illnesses.

MalaCards: Hyperglycemia, also known as hyperglycaemia, is related to diabetes mellitus and obesity. An important gene associated with Hyperglycemia is UNC13B (unc-13 homolog B (C. elegans)), and among its related pathways are Metabolism and Regulation of beta-cell development. The drugs insulin and insulin, aspart, human and the compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, kidney and liver, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Wikipedia:63 Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia, not to be confused... more...

Aliases & Classifications for Hyperglycemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Hyperglycemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus31.0GCK, GCG, GCGR, PDP1, AKR1B1, IAPP
2obesity30.7AKR1B1, GCG, GCGR, GCK, PDP1, IAPP
3pancreatitis30.7GCG, INS
4hypoglycemia30.7AKR1B1, INS, GIP, IAPP, PCK2, GCGR
5ischemia30.7GCK, GCG, PDP1, AHSP, AKR1B1
6type 2 diabetes mellitus30.6GLO1, GCGR, GCK, PDP1, PDX1, AKR1B1
7myocardial infarction30.6GCG, AKR1B1, AHSP, PDX1
8glucose intolerance30.3INS, IAPP, GCK, GCGR, GCG
9gestational diabetes30.3IAPP, GCK, GCG, INS
10diabetic nephropathy30.2IAPP, INS, AKR1B1
11vascular disease30.1GCG
12hyperinsulinism30.0GCK, INS, GIP, GCG
13coronary artery disease30.0AHSP, INS, GCG, AKR1B1
14permanent neonatal diabetes mellitus30.0GCK, INS
15diabetic neuropathy29.9INS, AKR1B1
16essential hypertension29.8IAPP, GCGR, AHSP, INS
17autonomic neuropathy29.8GCG, AKR1B1, INS
18diabetic autonomic neuropathy29.8AKR1B1
19insulin resistance29.7GCK, GCGR, PDP1, IAPP, INS, PAX4
20type 1 diabetes29.7GLO1, IAPP, PDX1, INS, PAX4, GCK
21insulinoma29.7INS, MAFA, PDX1, GCG, IAPP, PAX4
22metabolic syndrome x29.7IAPP, AKR1B1, GCK, GCG, INS
23maturity-onset diabetes of the young29.7INS, GCK, PDX1, PAX4
24lactic acidosis29.7GCG, INS
25neuroendocrine tumor29.7GCG
26hepatitis10.4
27cerebritis10.4
28retinitis10.4
29atherosclerosis10.3
30acute myocardial infarction10.3
31hypertension10.3
32leukemia10.3
33diabetic ketoacidosis10.3
34type 1 diabetes mellitus10.3
35acute leukemia10.3
36neuronitis10.1
37acute lymphocytic leukemia10.1
38kidney disease10.1
39stroke, ischemic10.1
40hypokalemia10.1
41metabolic acidosis10.1
42diabetic retinopathy10.1
43polyneuropathy10.1
44acute pancreatitis10.0
45diabetic polyneuropathy10.0
46hepatitis a10.0
47breast cancer10.0
48galactosemia10.0
49lymphopenia10.0
50methylmalonic acidemia10.0

Graphical network of the top 20 diseases related to Hyperglycemia:



Diseases related to hyperglycemia

Clinical Features for Hyperglycemia

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Genetic Tests for Hyperglycemia

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Anatomical Context for Hyperglycemia

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32MalaCards
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MalaCards organs/tissues related to Hyperglycemia:

32
Endothelial, Kidney, Liver, Brain, Heart, Smooth muscle, Skeletal muscle, Monocytes, Adipocyte, Lung, Testes, Prostate, Pancreas, Pancreatic islet, Breast, Bone, Thyroid, Bone marrow, Pituitary, Retina, Ovary, Dorsal root ganglion, Fetal liver, Cortex, Spinal cord, Small intestine, Eye, Thymus, Myeloid, Prefrontal cortex, Fetal brain

Animal Models for Hyperglycemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperglycemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.8PAX4, GCG, GCGR, GCK, PDX1, AKR1B1
2MP:000537611.5INS, GCG, GCGR, GCK, PDX1, AKR1B1
3MP:000536711.3INS, MAFA, FN3K, AKR1B1, PDX1, GCK
4MP:000537911.3GCG, GCK, PDX1, MAFA, INS, PAX4

Publications for Hyperglycemia

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50PubMed
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Articles related to Hyperglycemia:

(show top 50)    (show all 1047)
idTitleAuthorsYear
1
Diabetes and hyperglycemia in the critical care setting: has the evidence for glycemic control vanished? (Or a8 (24277672)
is going awa
2
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
3
The influence of hyperglycemia on the therapeutic effect of exercise on glycemic control in patients with type 2 diabetes mellitus. (23817567)
2013
4
Inhibitory effects of medicinal mushrooms on I+-amylase and I+-glucosidase - enzymes related to hyperglycemia. (23396484)
2013
5
Ameliorative effect of naringenin on hyperglycemia-mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin- nicotinamide-induced experimental diabetes mellitus. (23841752)
2013
6
Ileal interposition surgery-induced improvement of hyperglycemia and insulin resistance in Goto-Kakizaki rats by upregulation of TCF7L2 expression. (23737909)
2013
7
Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia. (23279876)
2013
8
Cellular responses of novel human pancreatic ?-cell line, 1.1B4 to hyperglycemia. (23985558)
2013
9
Severe hyperglycemia immediately after allogeneic hematopoietic stem-cell transplantation is predictive of acute graft-versus-host disease. (22987342)
2013
10
Potential of birds to serve as a pathology-free model of Type 2 Diabetes, 1: Is the apparent absence of the RAGE gene a factor in the resistance of avian organisms to chronic hyperglycemia? (24313337)
2013
11
Disrupted daily light-dark cycle induces the expression of hepatic gluconeogenic regulatory genes and hyperglycemia with glucose intolerance in mice. (23376072)
2013
12
The prophylactic role of D-saccharic acid-1,4-lactone against hyperglycemia-induced hepatic apoptosis via inhibition of both extrinsic and intrinsic pathways in diabetic rats. (23138840)
2013
13
Inpatient management of diabetes and hyperglycemia. (23688537)
2013
14
Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFI^3 expression contributes to the delay of epithelial wound healing in diabetic corneas. (24306208)
2013
15
Applicability of homeostasis model assessment of insulin resistance to patients with hyperglycemia: reply to Kawada. (23860957)
2013
16
Factors associated with hyperglycemia and low insulin levels in children undergoing cardiac surgery with cardiopulmonary bypass who received a single high dose of methylprednisolone. (23420163)
2013
17
Effect of hyperglycemia on conduction parameters of tibial nerve's fibers to different muscles: A rat model. (23546340)
2013
18
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
19
Initial combination with linagliptin and metformin in newly diagnosed type 2 diabetes and severe hyperglycemia. (23212658)
2012
20
Hyperglycemia suppresses cardiac stem cell homing to peri-infarcted myocardium via regulation of ERK1/2 and p38 MAPK activities. (22965067)
2012
21
Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. (23304131)
2012
22
Hyperglycemia-induced abnormalities in rat and human corneas: the potential of second harmonic generation microscopy. (23139780)
2012
23
Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy. (22586581)
2012
24
Pharmacotherapy of hyperglycemia. (19743938)
2009
25
Hyperglycemia suppresses hepatic scavenger receptor class B type I expression. (17957039)
2008
26
Suppressive effect of short-interfering RNA on hyperglycemia-induced expression of intercellular adhesion molecule-1 on cultured vascular endothelial cells. (18365231)
2008
27
Hyperglycemia in celiac disease: not always pretype 1 diabetes? (18768037)
2008
28
Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy. (18556343)
2008
29
Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. (18420487)
2008
30
Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line. (18469441)
2008
31
Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects. (17303805)
2007
32
Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. (17272778)
2007
33
Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans. (16731846)
2006
34
Association of SH-2 containing inositol 5'-phosphatase 2 gene polymorphisms and hyperglycemia. (16804414)
2006
35
Gender differences in renal responses to hyperglycemia and angiotensin-converting enzyme inhibition in diabetes. (16164648)
2005
36
Acute hyperglycemia and activation of the beta-adrenergic system do not exhibit synergistic inhibitory actions on thyrotropin-releasing hormone (TRH)-induced thyroid stimulating hormone (TSH) secretion. (15758560)
2005
37
Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone. (15894868)
2005
38
Reduced insulin and IGF-I signaling, not hyperglycemia, underlies the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach. (15855342)
2005
39
Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen. (15022284)
2004
40
Reversal of glucose-insulin-potassium-induced hyperglycemia by aggressive insulin treatment in postoperative heart failure. An observational study. (15103177)
2004
41
Hyperglycemia in critically ill patients: clinical implications for treatment]. (15694061)
2004
42
Management of hyperglycemia in minority children with type 2 diabetes mellitus. (12017228)
2002
43
Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene. (12460054)
2002
44
Hyperglycemia enhances DNA fragmentation after transient cerebral ischemia. (11333367)
2001
45
Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. (9591763)
1998
46
Effects of hyperglycemia on cerebral blood flow and edema formation after carotid artery occlusion in Fischer 344 rats. (9416270)
1997
47
Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. (8822980)
1996
48
Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus. (1727820)
1992
49
Methylmalonic acidemia with the unusual complication of severe hyperglycemia. (7046992)
1982
50
Lipoatrophic diabetes: a new variant characterized by tapeto-retinal degeneration, late onset generalized lipoatrophy, insulin-resistant hyperglycemia and hyperlipidemia. (5051798)
1972

Genetic Variations for Hyperglycemia

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Expression for genes affiliated with Hyperglycemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperglycemia

Search GEO for disease gene expression data for Hyperglycemia.

Pathways for genes affiliated with Hyperglycemia

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3GCG, PCK2, AKR1B1, PDP1, GCK, DDOST
2
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11.1IAPP, PDX1, MAFA, GCK, INS, PAX4
311.0GCK, GCG, PDX1, GIP, INS
4
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11.0GIP, GCG, GCGR, NTSR1, IAPP
5
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10.9MAFA, PDX1, INS, GCK
6
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10.9GIP, IAPP, GCG, GCGR
710.9INS, PCK2, PDX1, GCG
810.8GCK, PDX1, INS
910.8PDX1, IAPP, INS
1010.8AKR1B1, PCK2, GLO1
11
Hide members
10.8GCG, INS, GIP
1210.8IAPP, GCG, INS
13
Hide members
10.8INS, GCGR, GCG
14
Hide members
10.7GCG, GIP

Compounds for genes affiliated with Hyperglycemia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Hyperglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1glucose4412.8AHSP, IAPP, GCG, GCK, PDP1, PDX1
2lipid4411.9PCK2, GCG, GCK, INS, IAPP, NTSR1
3lactate4411.8AKR1B1, IAPP, PDP1, GCK, GLO1, PCK2
4arginine4411.8GCK, AKR1B1, SLC5A2, INS, GCG, IAPP
5alanine4411.8GCG, GCK, PCK2, PDP1, GIP, GLO1
6atp44 2812.7GLO1, GCK, PCK2, AHSP, FN3K, PDP1
7incretin4411.7PDX1, IAPP, GCGR, GIP, GCG, INS
8streptozotocin4411.7IAPP, PDX1, AKR1B1, GCK, GCG, INS
9epinephrine44 11 2413.7INS, GIP, IAPP, AKR1B1, PDP1, GCGR
10glycogen44 2412.7IAPP, GCGR, GCK, PDP1, PCK2, INS
11creatinine4411.7GCK, GLO1, INS, GIP, GCG, AKR1B1
12adenylate4411.7GCK, AKR1B1, GIP, GLO1, IAPP, GCGR
13sulfonylurea4411.6GCK, PDX1, IAPP, GIP, INS, GCG
14c-peptide4411.6INS, GIP, GCK, GCG, PDX1, IAPP
15i-app4411.5IAPP, PDX1, GCG, INS, GCK
16glutamine4411.5PDP1, GCK, GCG, AKR1B1, GLO1, PCK2
17fatty acid4411.5GCGR, GCG, GCK, INS, PDP1, PCK2
18fructose44 1112.5GCG, GCGR, AKR1B1, PCK2, GCK
19cysteine4411.4AKR1B1, IAPP, GCK, GCG, GLO1, AHSP
20cyclic amp44 2412.4IAPP, GCGR, GCG, GIP, PCK2, AHSP
21carbohydrates4411.4PDP1, GCG, GLO1, INS, GCK
22glycerol44 11 2413.4INS, AKR1B1, GCK, GCG, PCK2
23liraglutide44 28 1113.4GCG, IAPP, GIP, INS
24sitagliptin44 1112.4GCG, INS, GIP, IAPP
25repaglinide44 49 1113.3PAX4, INS, IAPP, GCG
26proglucagon4411.3PDX1, GCK, GIP, GCG
27indomethacin44 59 28 1114.3AHSP, GLO1, IAPP, AKR1B1, GCG
28katp4411.3INS, GCG, GCK, PDX1
29acetylcholine44 49 28 11 2415.3GCG, PDP1, UNC13B, IAPP, AHSP
30nicotinamide44 1112.3INS, GCG, PDX1, AKR1B1
31metformin44 49 1113.3GCK, GCG, IAPP, INS
32wortmannin4411.2INS, PCK2, PDX1, GIP, GCG
33exenatide44 1112.2INS, IAPP, GCG
34preproinsulin4411.2PDX1, GCK, INS
35glyceraldehyde44 2412.2AKR1B1, GCK, GLO1
36acarbose44 1112.2INS, GCG, IAPP
37fructosamine44 2412.2FN3K, INS, IAPP
38pramlintide44 1112.2GCG, INS, IAPP
39ibmx44 28 5913.1INS, PCK2, IAPP, GCG
40miglitol44 59 1113.1INS, IAPP, GCG
41forskolin44 49 1113.0IAPP, GCG, GCK, GIP, PDX1
42tolbutamide44 49 28 1114.0INS, GCK, GCG
43voglibose44 1112.0GCG, INS
44phenylglyoxal4410.9GLO1, AKR1B1
45norepinephrine44 11 2412.9AHSP
46meglitinide4410.8GCG, INS
47chromium picolinate4410.8INS, GCK
48hbig4410.7INS, AKR1B1
49vildagliptin44 1111.6INS, GCG
50aicar44 11 2412.5INS, PCK2, GCK

GO Terms for genes affiliated with Hyperglycemia

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16Gene Ontology
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Cellular components related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.8INS, GIP, GCG

Biological processes related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1endocrine pancreas developmentGO:03101811.4PAX4, INS, GIP, IAPP, PDX1, GCK
2small molecule metabolic processGO:04428111.4INS, GCG, GCGR, GCK, PDP1, AKR1B1
3carbohydrate metabolic processGO:00597511.2PCK2, GLO1, AKR1B1, GCK, SLC5A2
4regulation of insulin secretionGO:05079611.2INS, GCG, GCK, GIP
5glucose homeostasisGO:04259311.2PDX1, GCK, GCGR, INS
6positive regulation of insulin secretionGO:03202411.0GCK, PDX1, GIP
7detection of glucoseGO:05159410.9PDX1, GCK
8negative regulation of gluconeogenesisGO:04572110.9GCK, INS
9energy reserve metabolic processGO:00611210.8INS, GCGR, GCG
10positive regulation of glycolysisGO:04582110.8GCK, INS
11nitric oxide mediated signal transductionGO:00726310.7PDX1, MAFA
12positive regulation of glycogen biosynthetic processGO:04572510.6GCK, INS
13glucose metabolic processGO:00600610.5PDX1, PCK2, INS

Molecular functions related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.9INS, GIP, IAPP, GCG

Products for genes affiliated with Hyperglycemia

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Sources for Hyperglycemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet