MCID: HYP066
MIFTS: 62

Hyperglycemia malady

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Summaries for Hyperglycemia

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34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Hyperglycemia means high blood sugar or glucose. glucose comes from the foods you eat. insulin is a hormone that moves glucose into your cells to give them energy. hyperglycemia happens when your body doesn't make enough insulin or can't use it the right way. people with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. other problems that can raise blood sugar include infections, certain medicines, hormone imbalances, or severe illnesses.

MalaCards: Hyperglycemia, also known as hyperglycaemia, is related to insulin resistance and ischemia. An important gene associated with Hyperglycemia is UNC13B (unc-13 homolog B (C. elegans)), and among its related pathways are G alpha (s) signalling events and Selected targets of HNF1. The drugs insulin and insulin, aspart, human and the compounds hbig and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include endothelial, kidney and liver, and related mouse phenotypes are normal and renal/urinary system.

Wikipedia:65 Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglyc more...

Aliases & Classifications for Hyperglycemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Hyperglycemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance30.8INS, GIP, IAPP, PCK2, PDP1, GCGR
2ischemia30.7MLN, AHSP, AKR1B1, PDP1, GCK
3diabetes mellitus30.6PCK2, AKR1B1, IAPP, GIP, TXNIP, INS
4obesity30.5MLN, INS, GIP, IAPP, AKR1B1, PDP1
5type 1 diabetes mellitus30.5INS, GCK
6hypoglycemia30.5MLN, INS, GIP, IAPP, AKR1B1, PCK2
7gestational diabetes30.4INS, IAPP, GCK
8glucose intolerance30.4MLN, SLC5A2
9diabetic nephropathy30.3INS, IAPP, AKR1B1
10vascular disease30.2AHSP, INS, AKR1B1
11type 2 diabetes mellitus30.2INS, SLC5A2, GCK, GCGR, PDP1, PDX1
12hyperinsulinism30.2GCK, GIP, INS
13coronary artery disease30.1AKR1B1, INS, AHSP
14diabetic neuropathy30.1INS, AKR1B1
15diabetic autonomic neuropathy30.1AKR1B1
16permanent neonatal diabetes mellitus30.1GCK, INS
17pancreatic cancer29.9PDX1, NTSR1, IAPP, INS
18autonomic neuropathy29.9MLN, INS, AKR1B1
19essential hypertension29.8AHSP, INS, IAPP, GCGR
20hyperuricemia29.8INS, GCK
21metabolic syndrome x29.8INS, IAPP, AKR1B1, GCK
22maturity-onset diabetes of the young29.8INS, PDX1, GCK
23hypercholesterolemia29.7AHSP, INS, PDX1
24insulinoma29.7INS, IAPP, MAFA, PDX1, GCK
25endotheliitis10.7
26pancreatitis10.5
27hepatitis10.5
28cerebritis10.4
29myocardial infarction10.4
30retinitis10.4
31atherosclerosis10.4
32hypertension10.3
33leukemia10.3
34diabetic ketoacidosis10.3
35hypertriglyceridemia10.2
36neuronitis10.2
37acute lymphocytic leukemia10.2
38acute myocardial infarction10.2
39hypoxia10.2
40blindness10.2
41hypokalemia10.1
42metabolic acidosis10.1
43diabetic retinopathy10.1
44kidney disease10.1
45polyneuropathy10.1
46chorea10.1
47sepsis10.1
48familial hyperinsulinism10.1GCK
49pancreatic agenesis10.1PDX1
50acute myocarditis10.1

Graphical network of the top 20 diseases related to Hyperglycemia:



Diseases related to hyperglycemia

Symptoms for Hyperglycemia

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Genetic Tests for Hyperglycemia

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Anatomical Context for Hyperglycemia

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33MalaCards
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MalaCards organs/tissues related to Hyperglycemia:

33
Endothelial, Kidney, Liver, Brain, Heart, Skeletal muscle, Smooth muscle, Monocytes, Adipocyte, Lung, Prostate, Testes, Bone, Pancreatic islet, Breast, Pancreas, Ovary, Thyroid, Bone marrow, Pituitary, Retina, Spinal cord, Eye, Fetal liver, Dorsal root ganglion, Prefrontal cortex, Small intestine, Cortex, Myeloid, Thymus, Fetal brain

Animal Models for Hyperglycemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hyperglycemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9TXNIP, NTSR1, MAFA, PDX1, GCGR, INS
2MP:00053677.6FN3K, INS, TXNIP, AKR1B1, MAFA, PDX1
3MP:00053766.4SLC5A2, FN3K, INS, TXNIP, GIP, IAPP
4MP:00053786.4INS, TXNIP, GIP, IAPP, AKR1B1, NTSR1

Publications for Hyperglycemia

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Sources:
52PubMed
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Articles related to Hyperglycemia:

(show top 50)    (show all 1038)
idTitleAuthorsYear
1
Immunological characteristics of human umbilical cord mesenchymal stem cells and the therapeutic effects of their transplantion on hyperglycemia in diabetic rats. (24297321)
2014
2
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men. (24026559)
2013
3
GALNT2 expression is reduced in patients with Type 2 diabetes: possible role of hyperglycemia. (23894607)
2013
4
Mild fasting hyperglycemia shifts fuel reliance toward fat during exercise in adults with impaired glucose tolerance. (23599396)
2013
5
Comment on: Draznin et al. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care 2013;36:1807-1814. (24265388)
2013
6
Hyperglycemia, insulin resistance, impaired pancreatic I^-cell function, and risk of pancreatic cancer. (23847240)
2013
7
Hyperglycemia induces altered expressions of angiogenesis associated molecules in the trophoblast. (23983782)
2013
8
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
9
Stress hyperglycemia in acute ST-segment elevation myocardial infarction is a marker of left ventricular remodeling. (23738623)
2013
10
Surge in regulatory cells does not prevent onset of hyperglycemia in NOD mice. (24328490)
2013
11
The possible mechanisms underlying the impairment of HIF-1I+ pathway signaling in hyperglycemia and the beneficial effects of certain therapies. (23983604)
2013
12
Maternal testosterone levels are associated with C-peptide levels in the Mexican American subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study cohort. (23757120)
2013
13
Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats. (23791753)
2013
14
Insulin sensitivity, but not hyperglycemia, may be superior as a prognostic marker and therapeutic target for diabetes in heart failure. (22964377)
2012
15
Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses. (22931303)
2012
16
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
17
Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)/calmodulin-dependent kinase II in retinal capillary endothelial cells. (23049237)
2012
18
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. (22569241)
2012
19
Hypo- and hyperglycemia in relation to the mean, standard deviation, coefficient of variation, and nature of the glucose distribution. (22953755)
2012
20
Mild hyperglycemia, but not glucagon-like peptide 1 predicts poor outcome after injury. (23231933)
2012
21
Positive correlation between chronic hyperglycemia and serum fetuin-A levels in middle-aged and elderly Chinese. (23190703)
2012
22
I+-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral I+-glucosidase inhibitor for improving postprandial hyperglycemia. (23106358)
2012
23
Hyperthyroidism presenting with hyperglycemia in an adolescent female. (21823542)
2011
24
Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. (20501596)
2010
25
Increased secretion of IP-10 from monocytes under hyperglycemia is via the TLR2 and TLR4 pathway. (19447045)
2009
26
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. (19074137)
2009
27
Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia. (19536400)
2009
28
Relationships between PON1 L55M polymorphism and coronary heart diseases complicated with fasting hyperglycemia in Han populations in Guangdong]. (19292048)
2009
29
Intensive insulin therapy in non-diabetic patients with myocardial infarction and hyperglycemia. INSUCOR study]. (18482525)
2008
30
Unexplained hyperglycemia in continuous subcutaneous insulin infusion: evaluation and treatment. (18375782)
2008
31
Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. (17955498)
2008
32
Refractive properties of the healthy human eye during acute hyperglycemia. (18389272)
2008
33
Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants. (18035140)
2007
34
Hyperglycemia induced oxidative stress in type-1 and type-2 diabetic patients with and without nephropathy. (17543235)
2007
35
Nateglinide improves postprandial hyperglycemia and insulin secretion in renal transplant recipients. (17425753)
2007
36
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. (15572028)
2005
37
Gender differences in renal responses to hyperglycemia and angiotensin-converting enzyme inhibition in diabetes. (16164648)
2005
38
Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. (18220582)
2005
39
Acute hyperglycemia alters von Willebrand factor but not the fibrinolytic system in elderly subjects with normal or impaired glucose tolerance. (15613917)
2004
40
Hyperglycemia downregulates total lipoprotein lipase activity in humans. (14984315)
2004
41
The effect of hyperglycemia on experimental retinal ischemia. (15006850)
2004
42
Hyperglycemia as a cardiovascular risk factor. (14678859)
2003
43
Human obesity and thinness, hyperlipidemia, hyperglycemia, and insulin resistance associated with HIV1 protease inhibitors. Prevention by alternating several antiproteases in short sequences. (10665336)
1999
44
Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. (9846581)
1998
45
Effect of induced hyperglycemia on contrast sensitivity function in insulin-dependent diabetic patients]. (7780272)
1995
46
Effects of hyperglycemia on interdigestive gastrointestinal motility in humans. (7886397)
1994
47
Low dose streptozotocin-induced diabetes in mice: reduced IL-2 production and modulation of streptozotocin-induced hyperglycemia by IL-2. (1428358)
1992
48
Hyperglycemia and toxic oil syndrome in Spain. (2060456)
1991
49
Effect of hyperglycemia on the status of antioxidant protection of erythrocytes in children with diabetes mellitus and in vitro]. (1946299)
1991
50
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. (2123890)
1990

Variations for Hyperglycemia

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Expression for genes affiliated with Hyperglycemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperglycemia

Search GEO for disease gene expression data for Hyperglycemia.

Pathways for genes affiliated with Hyperglycemia

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Sources:
50PathCards, 55Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 5Cell Signaling Technology, 51PharmGKB
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Pathways related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GIP, IAPP, GCGR
29.6PDX1, IAPP, INS
39.6INS, PDX1, GCK
4
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
9.5PCK2, PDP1, GCK
5
Show member pathways
9.3INS, GIP, PDX1, GCK
69.3PDX1, PCK2, INS
7
Show member pathways
9.0INS, MAFA, PDX1, GCK
8
Show member pathways
8.8INS, IAPP, MAFA, PDX1, GCK
9
Show member pathways
8.8GCK, PDX1, MAFA, IAPP, INS
10
Show member pathways
8.4GCGR, NTSR1, IAPP, GIP, MLN
11
Show member pathways
8.2DDOST, INS, AKR1B1, PCK2, PDP1, GCGR

Compounds for genes affiliated with Hyperglycemia

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB
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Compounds related to Hyperglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1hbig4510.3INS, AKR1B1
2Sorbitol2410.3AKR1B1, GCK
3glyceraldehyde45 2411.3GCK, AKR1B1
4chromium picolinate4510.2INS, GCK
5exenatide45 1111.2INS, IAPP
6alpha lipoic acid4510.1INS, AKR1B1, PDP1
7liraglutide45 29 1112.1IAPP, GIP, INS
8sitagliptin45 1111.1INS, GIP, IAPP
9fructosamine45 2411.0FN3K, INS, IAPP
10proglucagon4510.0GCK, PDX1, GIP
11preproinsulin4510.0GCK, PDX1, INS
12metformin45 51 1112.0GCK, IAPP, INS
13nicotinamide45 1110.9PDX1, AKR1B1, INS
14katp459.9INS, PDX1, GCK
15acarbose45 1110.8INS, IAPP
16glycerol 3-phosphate45 2410.8GCK, PDP1, PCK2
17i-app459.8GCK, PDX1, IAPP, INS
18aicar45 24 1111.8GCK, PCK2, INS
19norepinephrine45 24 1111.7AKR1B1, IAPP, INS, AHSP
20pramlintide45 1110.6IAPP, INS
21carnitine459.6INS, PCK2, PDP1
22glucose 6-phosphate45 2410.6FN3K, PCK2, GCK
23fructose45 1110.5AKR1B1, PCK2, GCGR, GCK
24glycerol45 24 1111.5GCK, PCK2, AKR1B1, INS
25creatinine459.5INS, GIP, IAPP, AKR1B1, GCK
26sulfonylurea459.5INS, GIP, IAPP, PDX1, GCK
27c-peptide459.5INS, GIP, IAPP, PDX1, GCK
28pyruvate459.5PCK2, PDX1, PDP1, GCK
29forskolin45 51 1111.4GCK, PDX1, IAPP, GIP
30epinephrine45 24 1111.3INS, GIP, IAPP, AKR1B1, PDP1, GCGR
31acetylcholine45 51 29 24 1113.2PDP1, IAPP, UNC13B, AHSP, MLN
32fatty acid459.2INS, PCK2, PDP1, GCGR, GCK
33lactate459.1INS, IAPP, AKR1B1, PCK2, PDP1, GCK
34incretin459.1INS, GIP, IAPP, PDX1, GCGR, GCK
35cyclic amp45 2410.1AHSP, GIP, IAPP, PCK2, GCGR
36streptozotocin459.1INS, IAPP, AKR1B1, PCK2, PDX1, GCK
37thymidine45 2410.0GIP, IAPP, NTSR1, PCK2, PDX1
38wortmannin459.0PDX1, PCK2, GIP, INS
39glycogen45 2410.0INS, IAPP, PCK2, PDP1, GCGR, GCK
40histamine45 29 2410.9GCGR, IAPP, AHSP, MLN
41oligonucleotide458.8IAPP, PCK2, PDX1, GCGR, GCK
42atp45 299.7FN3K, AHSP, IAPP, PCK2, PDP1, GCGR
43adenylate458.7MLN, GIP, IAPP, AKR1B1, GCGR, GCK
44arginine458.4MLN, AHSP, INS, GIP, IAPP, AKR1B1
45serine458.3MLN, INS, IAPP, AKR1B1, PDX1, PDP1
46alanine458.3MLN, INS, GIP, AKR1B1, PCK2, PDP1
47lipid458.0AHSP, INS, TXNIP, GIP, IAPP, NTSR1
48cholesterol45 29 24 1110.9MLN, AHSP, INS, TXNIP, IAPP, PCK2
49calcium45 51 24 1110.5MLN, AHSP, UNC13B, GIP, IAPP, NTSR1
50glucose454.7SLC5A2, AIR, FN3K, MLN, AHSP, INS

GO Terms for genes affiliated with Hyperglycemia

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16Gene Ontology
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Cellular components related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.9GIP, INS

Biological processes related to Hyperglycemia according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1detection of glucoseGO:05159410.2GCK, PDX1
2negative regulation of gluconeogenesisGO:04572110.1INS, GCK
3positive regulation of glycolytic processGO:04582110.1GCK, INS
4positive regulation of glycogen biosynthetic processGO:04572510.1GCK, INS
5glucose transportGO:0157589.9INS, GCK, SLC5A2
6regulation of insulin secretionGO:0507969.9GCK, GIP, INS
7response to starvationGO:0425949.8GCGR, GIP
8nitric oxide mediated signal transductionGO:0072639.7MAFA, PDX1
9pyruvate metabolic processGO:0060909.6PDP1, PCK2
10glucose homeostasisGO:0425939.5INS, PDX1, GCGR, GCK
11carbohydrate metabolic processGO:0059759.5AKR1B1, PCK2, GCK, SLC5A2
12glucose metabolic processGO:0060069.4PDX1, PCK2, INS
13positive regulation of insulin secretionGO:0320249.4GIP, PCK2, PDX1, GCK
14endocrine pancreas developmentGO:0310189.4GCK, PDX1, IAPP, GIP, INS
15response to glucoseGO:0097499.3MAFA, GIP, TXNIP
16insulin secretionGO:0300739.3PDX1, MAFA
17small molecule metabolic processGO:0442818.6INS, AKR1B1, PCK2, PDP1, GCGR, GCK

Molecular functions related to Hyperglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.8IAPP, GIP, INS, MLN

Products for genes affiliated with Hyperglycemia

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  • Antibodies
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Sources for Hyperglycemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet