MCID: HYP037
MIFTS: 50

Hyperhomocysteinemia malady

Categories: Metabolic diseases

Aliases & Classifications for Hyperhomocysteinemia

Aliases & Descriptions for Hyperhomocysteinemia:

Name: Hyperhomocysteinemia 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9279
MeSH 42 D020138
NCIt 47 C84770
SNOMED-CT 64 419503008
UMLS 69 C0598608

Summaries for Hyperhomocysteinemia

Disease Ontology : 12 An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood.

MalaCards based summary : Hyperhomocysteinemia is related to myocardial infarction and budd-chiari syndrome. An important gene associated with Hyperhomocysteinemia is FOLH1 (Folate Hydrolase 1), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs Amlodipine and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and heart, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Wikipedia : 71 Hyperhomocysteinemia or hyperhomocysteinaemia is a medical condition characterized by an abnormally high... more...

Related Diseases for Hyperhomocysteinemia

Diseases related to Hyperhomocysteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.6 ALB APOE CBS CCL2 F5 MTHFR
2 budd-chiari syndrome 28.3 APOE F5 MTHFR NOS3 SERPINC1 SERPINE1
3 mthfr thermolabile variant 11.0
4 homocystinuria, b6-responsive and nonresponsive types 10.8
5 multiple familial trichoepithelioma 10.4 F5 MTHFR
6 homocystinuria due to mthfr deficiency 10.4 MTHFR MTR
7 x-linked disease 10.3 MTR MTRR
8 autosomal dominant disease 10.3 MTR MTRR
9 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.3 F5 MTHFR
10 hereditary acrokeratotic poikiloderma, weary type 10.3 MTHFD1 MTHFR
11 intracranial cysts 10.3 MTHFR NOS3
12 thrombosis 10.3
13 kartagener syndrome 10.3 MTHFR NOS3
14 myh7-related myosin storage myopathy 10.3 CBS MTHFR MTR
15 myelocystocele 10.3 MTHFD1 MTHFR
16 freiberg's disease 10.3 ALB SERPINC1
17 posterior meningocele 10.3 MTHFD1 MTHFR
18 pericardial and diaphragmatic defect 10.3 MTHFD1 MTHFR
19 hereditary thrombocytopenia with normal platelets 10.3 MTHFD1 MTHFR
20 borderline glaucoma 10.3 CBS MTHFR MTR
21 thoracolumbosacral spina bifida aperta 10.3 MTHFD1 MTHFR
22 lumbosacral spina bifida aperta 10.3 MTHFD1 MTHFR
23 warburg micro syndrome 3 10.3 MTHFR MTR MTRR
24 cervical spina bifida aperta 10.3 MTHFD1 MTHFR
25 mycophenolate mofetil embryopathy 10.3 MTHFD1 MTHFR
26 vascular erectile tumor 10.3 F5 MTHFR SERPINC1
27 complication in hemodialysis 10.3 MTHFD1 MTHFR
28 agammaglobulinemia 2 10.3 MTHFR MTR MTRR
29 hypertrichosis 10.3 F5 MTHFR SERPINC1
30 left-right axis malformations 10.3 F5 MTHFR SERPINC1
31 intermediate maple syrup urine disease 10.2 MTHFD1 MTHFR
32 angular blepharoconjunctivitis 10.2 F5 MTHFR SERPINC1
33 blepharoconjunctivitis 10.2 F5 MTHFR SERPINC1
34 46,xx disorder of sex development-anorectal anomalies syndrome 10.2 MTHFD1 MTHFR
35 vaginal glandular tumor 10.2 MTHFR MTR MTRR
36 thrombophilia due to activated protein c resistance 10.2 F5 MTHFR SERPINC1
37 spinal multifocal clear cell meningioma 10.2 F5 MTHFR SERPINC1
38 lung cancer 10.2 F5 MTHFR
39 glycogen storage disease due to liver phosphorylase kinase deficiency 10.2 MTHFD1 MTHFR
40 villous adenoma 10.2 F5 MTHFR NOS3
41 ezh2-related overgrowth 10.2 MTR MTRR
42 methylmalonic aciduria and homocystinuria, cblc type 10.2 CBS MTHFD1 MTR
43 dentine erosion 10.2 F5 MTHFR SERPINC1
44 alpha-2-plasmin inhibitor deficiency 10.2 MTHFR NOS3 SERPINC1
45 exophthalmic ophthalmoplegia 10.2 ALB F5 SERPINC1
46 familial progressive cardiac conduction defect 10.2 ALB APOE
47 mechanical entropion 10.2 APOE NOS3
48 pancreatic ductal carcinoma 10.2 F5 SERPINC1
49 chronic tic disorder 10.2 ALB F5 SERPINC1
50 ocular hyperemia 10.2 MTHFR SERPINC1 THBD

Graphical network of the top 20 diseases related to Hyperhomocysteinemia:



Diseases related to Hyperhomocysteinemia

Symptoms & Phenotypes for Hyperhomocysteinemia

GenomeRNAi Phenotypes related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.8 APOE F5 FOLH1

MGI Mouse Phenotypes related to Hyperhomocysteinemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 ALB APOE BHMT CTH F5 MTHFD1
2 liver/biliary system MP:0005370 9.81 SERPINE1 THBD ALB APOE BHMT CTH
3 mortality/aging MP:0010768 9.73 MTHFD1 MTHFR MTR NOS3 SERPINC1 SERPINE1
4 renal/urinary system MP:0005367 9.23 ALB APOE BHMT CTH NOS3 SERPINC1

Drugs & Therapeutics for Hyperhomocysteinemia

Drugs for Hyperhomocysteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
2
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
3
Enalapril Approved, Vet_approved Phase 4,Phase 2,Phase 3 75847-73-3 5362032 40466924
4
Enalaprilat Approved Phase 4,Phase 2,Phase 3 76420-72-9 6917719
5
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
6
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-05-9 54575, 6560146 143
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
8
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 68-19-9 44176380
9
Maleic acid Experimental Phase 4,Phase 2,Phase 3 110-16-7 444266
10 calcium channel blockers Phase 4,Phase 2,Phase 3
11 Hematinics Phase 4,Phase 2,Phase 3,Phase 1
12 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
13 Vasodilator Agents Phase 4,Phase 2,Phase 3
14 Vitamin B 12 Phase 4,Phase 3,Phase 2
15 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1
16 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
17 Antihypertensive Agents Phase 4,Phase 2,Phase 3
18 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
19 Calcium, Dietary Phase 4,Phase 2,Phase 3
20 Neurotransmitter Agents Phase 4,Phase 3
21
protease inhibitors Phase 4,Phase 2,Phase 3
22 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
23 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2,Phase 3
24 diuretics Phase 4
25 Adrenergic Agents Phase 4
26 Natriuretic Agents Phase 4
27 Adrenergic Antagonists Phase 4
28 Sodium Chloride Symporter Inhibitors Phase 4
29 Adrenergic beta-Antagonists Phase 4
30 Folate Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
31 Vitamin B12 Nutraceutical Phase 4,Phase 3,Phase 2
32
Cobalamin Nutraceutical Phase 4,Phase 3,Phase 2 13408-78-1 6438156
33
Methylcobalamin Experimental, Nutraceutical Phase 4,Phase 3,Phase 2 13422-55-4
34 Vitamin B9 Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
35
Hydroquinone Approved Phase 3 123-31-9 785
36
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 65-23-6 1054
37
Choline Approved, Nutraceutical Phase 3 62-49-7 305
38
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
39
Betaine Approved, Nutraceutical Phase 3,Phase 2 107-43-7 247
40
Pyridoxal Approved, Nutraceutical Phase 3,Phase 2 66-72-8 1050
41
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
42
Creatine Approved, Nutraceutical Phase 3,Early Phase 1 57-00-1 586
43 Gastrointestinal Agents Phase 3,Phase 2
44 Contraceptive Agents Phase 2, Phase 3
45 Contraceptives, Oral Phase 2, Phase 3
46 Contraceptives, Oral, Combined Phase 2, Phase 3
47 Nootropic Agents Phase 3
48 Vitamin B 6 Phase 3,Phase 2
49 Hypolipidemic Agents Phase 3,Phase 2
50 Protective Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show all 43)
id Name Status NCT ID Phase
1 Uremic Hyperhomocysteinemia -A Folate Trial for Possible Prevention of Cardiovascular Events Completed NCT00317005 Phase 4
2 Effect of Folic Acid Supplementation on Plasma Homocysteine Level in Obese Children Completed NCT01766310 Phase 4
3 The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia. Completed NCT00165711 Phase 4
4 Can Oral Vitamin B12 and Folate Supplementation Preserve Cognitive Function of Patients With Early Dementia? Completed NCT00164970 Phase 4
5 Feasibility Study of the Intensive Systolic Blood Pressure Control Enrolling by invitation NCT02817503 Phase 4
6 CSPPT- Chronic Kidney Diseases Study Withdrawn NCT01871740 Phase 4
7 Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine Unknown status NCT01848873 Phase 2, Phase 3
8 Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine Unknown status NCT01956786 Phase 2, Phase 3
9 Effects of Low-dose Complex B-vitamins on Homocysteine and Framingham Risk Score Among Chinese Elderly Completed NCT00755664 Phase 3
10 The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy Volunteers Completed NCT01371357 Phase 3
11 Vitamin B6 Effects for Women Taking Birth Control Pills Completed NCT01128244 Phase 2, Phase 3
12 The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment Recruiting NCT02575092 Phase 2, Phase 3
13 Homocystinuria: Treatment With N-Acetylcysteine Completed NCT00483314 Phase 2
14 EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment Completed NCT01793090 Phase 2
15 Betaine METABOLISM OF PATIENTS With Homocystinuria Recruiting NCT02404337 Phase 2
16 Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine Active, not recruiting NCT01192828 Phase 1, Phase 2
17 Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine Completed NCT00473200 Phase 1
18 Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns Completed NCT00877227 Phase 1
19 A Retrospective Analysis of Cerefolin NAC® in Cognitively Impaired Patients Unknown status NCT01594541
20 The Impact of EDCs Relative Markers and Reproductive Hormone in Taiwanese Women Unknown status NCT01996631
21 Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients Completed NCT01391416
22 Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis Completed NCT00004495
23 The Effect of Folic Acid Administration in the Progression of Microalbuminuria Completed NCT00737126
24 Plasma Homocysteine Distribution in the United States Completed NCT00005483
25 Effect of Vitamin B12 Supplementation on Glycaemic Control in Uncontrolled Hyperhomocysteinemic Type 2 Diabetic Patients Completed NCT02540642
26 Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function Completed NCT02392767
27 Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial Completed NCT01661309
28 5-Methyltetrahydrofolate Survival and Inflammation in ESRD Patients Completed NCT00626223
29 Effect of 1 Year Vitamin D or D Plus B-vitamins on Bone Markers in Elderly People (KnoVIB) Completed NCT02586181
30 Plasma Vitamin and Homocysteine Levels and Thrombosis in Patients With Ph-negative MPNs Completed NCT01878916
31 COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE Completed NCT02860338
32 NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support) Completed NCT01370954
33 Role of Systemic Inflammation in Increase of Cardio-vascular Risk in Chronic Obstructive Pulmonary Disease Completed NCT02888886
34 The Association of Ferrtin and Homocysteine Etc. With RI and MS in Polycystic Ovary Syndrome (PCOS) Completed NCT01600833
35 Homocyst(e)Ine, Vitamin Status, and CVD Risk Completed NCT00005482
36 Homocysteine and Progression of Atherosclerosis Completed NCT00005338
37 Study of Chronic Degenerative Diseases Completed NCT02495961
38 Study of Homocysteine Metabolism in Homocystinuria Completed NCT00004356
39 Effects of Oral Supplementation With Creatine on Systemic Microvascular Endothelial Function in Vegetarian Individuals Recruiting NCT02961972 Early Phase 1
40 Methylation Biosignature in Childhood Chronic Kidney Disease Recruiting NCT02022046
41 The Application of Digital Infrared Thermal Imaging in Peripheral Artery Disease of the Lower Extremities Recruiting NCT02783677
42 Clinical and Laboratory Study of Methylmalonic Acidemia Recruiting NCT00078078
43 Natural History Study of Cystathionine Beta-synthase Deficiency Homocystinuria (CBSDH) Recruiting NCT02998710

Search NIH Clinical Center for Hyperhomocysteinemia

Cochrane evidence based reviews: hyperhomocysteinemia

Genetic Tests for Hyperhomocysteinemia

Genetic tests related to Hyperhomocysteinemia:

id Genetic test Affiliating Genes
1 Hyperhomocysteinemia 29

Anatomical Context for Hyperhomocysteinemia

MalaCards organs/tissues related to Hyperhomocysteinemia:

39
Endothelial, Brain, Heart, Bone, Liver, Kidney, Testes

Publications for Hyperhomocysteinemia

Articles related to Hyperhomocysteinemia:

(show top 50) (show all 859)
id Title Authors Year
1
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia. ( 27901381 )
2017
2
Hyperhomocysteinemia in Greyhounds and its Association with Hypofolatemia and Other Clinicopathologic Variables. ( 27864850 )
2017
3
Therapeutic Potential of Progranulin in Hyperhomocysteinemia-Induced Cardiorenal Dysfunction. ( 27872232 )
2017
4
Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID). ( 27890830 )
2017
5
Is hyperhomocysteinemia a causal factor for heart failure? The impact of the functional variants of MTHFR and PON1 on ischemic and non-ischemic etiology. ( 27863359 )
2017
6
Combined Effect of Hyperhomocysteinemia and Hypertension on the Presence of Early Carotid Artery Atherosclerosis. ( 26952151 )
2016
7
Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. ( 27929536 )
2016
8
Hyperhomocysteinemia, MMPs and Cochlear Function: A Short Review. ( 27069322 )
2016
9
Relationship between cardio-ankle vascular index and homocysteine in hypertension subjects with hyperhomocysteinemia. ( 27653661 )
2016
10
Hyperhomocysteinemia increases the risk of chronic kidney disease in a Chinese middle-aged and elderly population-based cohort. ( 27822673 )
2016
11
The effect of levodopa benserazide hydrochloride on homocysteinemia levels in patients with Parkinson's disease and treatment of hyperhomocysteinemia. ( 27338068 )
2016
12
Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review. ( 27908565 )
2016
13
Hyperhomocysteinemia Alters Sinoatrial and Atrioventricular Nodal Function: Role of Magnesium in Attenuating These Effects. ( 26972302 )
2016
14
A case of hyperhomocysteinemia with retinitis pigmentosa - A rare presentation. ( 27728730 )
2016
15
The Effect of Hyperhomocysteinemia on Motor Symptoms, Cognitive Status, and Vascular Risk in Patients with Parkinson's Disease. ( 27642535 )
2016
16
Relationship between lifestyle factors and hyperhomocysteinemia in general Chinese population: a cross-sectional study. ( 27797301 )
2016
17
Role of Hyperhomocysteinemia and Methylene Tetrahydrofolate Reductase C677T Polymorphism in Idiopathic Portal Vein Thrombosis. ( 27051654 )
2016
18
Hyperhomocysteinemia, low vitamin B12, and low folic acid: Are risk factors of cerebral vascular thrombosis in northwest Iran? ( 27904562 )
2016
19
Creatine supplementation prevents hyperhomocysteinemia, oxidative stress and cancer-induced cachexia progression in Walker-256 tumor-bearing rats. ( 26781304 )
2016
20
Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the AI^-fibrinogen interaction. ( 27090576 )
2016
21
Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration. ( 26885895 )
2016
22
Nitrative Stress Participates in Endothelial Progenitor Cell Injury in Hyperhomocysteinemia. ( 27391949 )
2016
23
Intermedin Restores Hyperhomocysteinemia-induced Macrophage Polarization and Improves Insulin Resistance in Mice. ( 27080257 )
2016
24
Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress. ( 27389677 )
2016
25
Hyperhomocysteinemia is associated with decreased apolipoprotein AI levels in normal healthy people. ( 26758372 )
2016
26
Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis. ( 27065203 )
2016
27
Increased neutrophil to lymphocyte ratio in persons suffering from hypertension with hyperhomocysteinemia. ( 27009577 )
2016
28
Impact of Genetic Polymorphism of methylenetetrahydrofolate reductase C677T on Development of Hyperhomocysteinemia and Related Oxidative Changes in Egyptian I^-Thalassemia Major Patients. ( 27187171 )
2016
29
High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease. ( 27775590 )
2016
30
Association of Hyperhomocysteinemia with Stroke Recurrence after Initial Stroke. ( 27260368 )
2016
31
CerefolinNAC Therapy ofA Hyperhomocysteinemia Delays Cortical and White Matter Atrophy in Alzheimer's Disease and Cerebrovascular Disease. ( 27567825 )
2016
32
To study the prevalence of coronary artery disease in end-stage renal disease and its correlation with hyperhomocysteinemia. ( 27727564 )
2016
33
Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide. ( 27417104 )
2016
34
Daytime sleepiness is associated with hyperhomocysteinemia in rural area of China: A cross-sectional study. ( 27321249 )
2016
35
Interactions of hyperhomocysteinemia and T cell immunity in causation of hypertension. ( 27398734 )
2016
36
Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia. ( 27028508 )
2016
37
Erratum: Increased neutrophil to lymphocyte ratio in persons suffering from hypertension with hyperhomocysteinemia. ( 27491524 )
2016
38
Hyperhomocysteinemia Is Associated with Vitamin B-12 Deficiency: A Cross-sectional Study in a Rural, Elderly Population of Shanxi China. ( 27273348 )
2016
39
Hyperhomocysteinemia in ApoE-/- Mice Leads to Overexpression of Enhancer of Zeste Homolog 2 via miR-92a Regulation. ( 27936205 )
2016
40
HYPERHOMOCYSTEINEMIA AND ITS TREATMENT IN PATIENTS WITH PARKINSON'S DISEASE. ( 27698607 )
2016
41
The relationship between hyperhomocysteinemia and neurodegeneration. ( 27033101 )
2016
42
Novel Therapy of Hyperhomocysteinemia in Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementing Disorders. ( 27709231 )
2016
43
Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe(-/-) mice with hyperhomocysteinemia. ( 27181586 )
2016
44
Toll-like Receptor 4 Mutation Suppresses Hyperhomocysteinemia- Induced Hypertension. ( 27488663 )
2016
45
High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia. ( 27689109 )
2016
46
Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis. ( 26781015 )
2016
47
A case of vascular parkinsonism associated with hyperhomocysteinemia and methylenetetrahydrofolate reductase gene variant (C677T). ( 26797478 )
2016
48
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. ( 27349749 )
2016
49
The Effect of Folic Acid Supplementation on Hyperhomocysteinemia and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease: A Pilot Study. ( 28050421 )
2016
50
Atherogenesis: hyperhomocysteinemia interactions with LDL, macrophage function, paraoxonase 1, and exercise. ( 26849408 )
2016

Variations for Hyperhomocysteinemia

Expression for Hyperhomocysteinemia

Search GEO for disease gene expression data for Hyperhomocysteinemia.

Pathways for Hyperhomocysteinemia

Pathways related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 AHCY ALB APOE BHMT CBS CTH
2
Show member pathways
12.48 APOE MTHFD1 MTHFR MTR MTRR
3
Show member pathways
12.13 CBS CTH MTHFR MTR
4
Show member pathways
11.94 F5 SERPINC1 SERPINE1 THBD
5 11.81 F5 SERPINC1 SERPINE1 THBD
6
Show member pathways
11.76 AHCY BHMT CBS CTH FOLH1 MTHFD1
7
Show member pathways
11.72 AHCY BHMT CBS CTH MTR MTRR
8
Show member pathways
11.7 AHCY ALB APOE CBS CCL2 CTH
9 11.67 BHMT CBS CTH
10 11.55 CCL2 NOS3 SERPINE1 THBD
11
Show member pathways
11.35 BHMT CBS CTH
12 11.03 CCL2 NOS3 THBD
13 10.78 CTH MTR
14
Show member pathways
10.48 CBS MTHFR
15
Show member pathways
10.27 MTR MTRR

GO Terms for Hyperhomocysteinemia

Cellular components related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 AHCY ALB APOE BHMT CTH FOLH1
2 extracellular space GO:0005615 9.5 ALB APOE CCL2 F5 SERPINC1 SERPINE1
3 endoplasmic reticulum lumen GO:0005788 9.46 ALB APOE F5 SERPINC1
4 platelet alpha granule lumen GO:0031093 8.8 ALB F5 SERPINE1

Biological processes related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.92 ALB APOE F5 SERPINC1
2 cellular protein metabolic process GO:0044267 9.88 ALB APOE F5 SERPINC1
3 methylation GO:0032259 9.87 AHCY BHMT MTR MTRR
4 platelet degranulation GO:0002576 9.79 ALB F5 SERPINE1
5 hemostasis GO:0007599 9.71 F5 SERPINC1 THBD
6 cobalamin metabolic process GO:0009235 9.63 MTR MTRR
7 nitric oxide mediated signal transduction GO:0007263 9.61 APOE NOS3
8 positive regulation of monocyte chemotaxis GO:0090026 9.61 CCL2 SERPINE1
9 folic acid metabolic process GO:0046655 9.61 MTHFD1 MTHFR MTRR
10 high-density lipoprotein particle remodeling GO:0034375 9.6 ALB APOE
11 tetrahydrofolate interconversion GO:0035999 9.59 MTHFD1 MTHFR
12 negative regulation of fibrinolysis GO:0051918 9.58 SERPINE1 THBD
13 negative regulation of blood coagulation GO:0030195 9.58 APOE SERPINE1 THBD
14 S-adenosylmethionine metabolic process GO:0046500 9.56 BHMT MTHFR
15 homocysteine metabolic process GO:0050667 9.55 CBS MTHFR
16 negative regulation of platelet activation GO:0010544 9.54 APOE NOS3 THBD
17 cysteine biosynthetic process GO:0019344 9.52 CBS CTH
18 S-adenosylmethionine cycle GO:0033353 9.51 AHCY MTRR
19 methionine metabolic process GO:0006555 9.5 MTHFD1 MTHFR MTRR
20 hydrogen sulfide biosynthetic process GO:0070814 9.49 CBS CTH
21 homocysteine catabolic process GO:0043418 9.48 CBS MTRR
22 cysteine biosynthetic process via cystathionine GO:0019343 9.46 CBS CTH
23 methionine biosynthetic process GO:0009086 9.46 BHMT MTHFD1 MTR MTRR
24 transsulfuration GO:0019346 9.43 CBS CTH MTHFD1
25 sulfur amino acid metabolic process GO:0000096 9.26 AHCY BHMT MTR MTRR
26 cellular amino acid biosynthetic process GO:0008652 9.1 CBS CTH FOLH1 MTHFD1 MTR MTRR

Molecular functions related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 9.5 MTHFR MTRR NOS3
2 FMN binding GO:0010181 9.37 MTRR NOS3
3 modified amino acid binding GO:0072341 9.26 CBS MTHFR
4 NADPH-hemoprotein reductase activity GO:0003958 9.16 MTRR NOS3
5 pyridoxal phosphate binding GO:0030170 9.13 ALB CBS CTH
6 NADP binding GO:0050661 8.8 MTHFR MTRR NOS3

Sources for Hyperhomocysteinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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