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Hyperhomocysteinemia malady
110 genes, 11 tissues, 952 related diseases, 26 phenotypes, 298 articles, clinical trials.

Summaries for Hyperhomocysteinemia

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Wikipedia: Hyperhomocysteinemia or hyperhomocysteinaemia is a medical condition characterized by an abnormally...44 more...

MalaCards: Hyperhomocysteinemia is related to thrombosis and atherosclerosis. An important gene associated with Hyperhomocysteinemia is FOLH1 (folate hydrolase (prostate-specific membrane antigen) 1), and among its related pathways are Antimetabolite Pathway - Folate Cycle, Pharmacodynamics and Methionine metabolism. The compounds hirudin and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Disease Ontology: An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood.6

Aliases & Descriptions for Hyperhomocysteinemia

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH
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Aliases & Descriptions:

hyperhomocysteinemia 6 8 32 43

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SNOMED-CT40 419503008

Related Diseases for Hyperhomocysteinemia

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13GeneCards, 14GeneDecks
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Diseases related to hyperhomocysteinemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 949)
idRelated DiseaseScoreTop Affiliating Genes
1thrombosis34.7MTHFR, FGB, F8, F5, F2
2atherosclerosis32.2SELE, LCAT, CETP, ELN
3venous thrombosis32.1VWF, SELP, SERPINC1, SERPINE1, MTHFR, MTR
4thromboembolism31.5VWF, SELP, SERPINC1, SERPINE1, MTHFR, MTR
5myocardial infarction30.8APOB, APOE, ACE, THBD
6vitamin b12 deficiency29.6MTHFR, MTR, TCN1, TCN2
7protein s deficiency29.4SERPINC1, CETP, F9, F5, RHD
8arterial occlusive disease29.4VWF, SELE, SELP, VCAM1, MTHFR, CCL2
9alcoholism29.1GSR, IL1RN, MAOB, ALAD, COMT, G6PD
10deep vein thrombosis29.0VWF, SELP, SERPINC1, SERPINE1, MTRR, MTHFR
11central retinal vein occlusion28.8VWF, SERPINC1, SERPINE1, MTHFR, IL6, APOH
12hepatitis28.7SELP, GSR, F2, ALB, TXN, DNMT1
13protein c deficiency28.6SERPINC1, SERPINE1, MTHFR, APOH, F9, F8
14hepatitis c28.2GSR, IL18, F2, TXN, LSL, GGT1
15orofacial cleft28.2BHMT, MTRR, MTHFR, MTR, MTHFD1, APEX1
16abdominal aortic aneurysm28.1CETP, FBN1, CCL2, ELN, CST3
17homocystinuria28.0SERPINC1, BHMT, MTRR, MTHFR, MTR, MMD
18hypermethioninemia28.0GNMT, CBS, CAT, CTH, AHCY, SOD1
19congenital heart defect27.9MTHFR, GJA1, GJA5, COMT, NPPB, SLC19A1
20lewy body dementia27.6BCHE, APOE, APP, MAOB
21marfan syndrome27.6MTHFR, FBN1, F9, CBS, PPARG, ELN
22osteonecrosis27.5VWF, SERPINC1, SERPINE1, MTHFR, APOA1, APOB
23portal vein thrombosis27.4SELP, SERPINC1, SERPINE1, MTHFR, APOH, F8
24insulin resistance27.4UCP2, INS, SOD1, SOD3
25venous insufficiency27.3SELP, SERPINE1, VCAM1, MTHFR, FGF2, F5
26parkinson's disease27.3BCHE, MTR, GSR, APOE, APP, MAOB
27antiphospholipid syndrome27.0VWF, SELE, SELP, SERPINC1, SERPINE1, VCAM1
28behcet's disease26.8SELE, IL18, IL8, APOH, F5, HSPG2
29vascular disease26.8VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
30hypoparathyroidism26.4MTHFR, INS, IGF1, F9, CASR
31retinal artery occlusion26.1SERPINC1, SERPINE1, MTHFR, ITGB3, IL6, APOH
32chronic myeloproliferative disease26.0MTHFR, IL1B, IL6, F7, F5, F2
33inflammatory bowel disease25.8SELE, SELP, VCAM1, CHUK, IL18, IL1B
34retinal vein occlusion25.2VWF, SERPINC1, SERPINE1, MTHFR, ITGB3, FGB
35systemic lupus erythematosus24.5VWF, SELE, VCAM1, IL18, IL1R1, IL1RN
36crohn's disease24.0CHUK, IL18, IL1B, IL1R1, IL1RN, IL6
37ulcerative colitis23.6SELE, SELP, IL18, IL1B, IL1R1, IL1RN
38end stage renal failure22.7SELP, INS, IL1RN, IL6, IGF1, ALB
39uremia22.7VWF, SERPINC1, SERPINE1, LPA, VCAM1, BHMT
40arteriosclerosis22.3SELE, SELP, SERPINE1, LPA, VCAM1, MTHFR
41homocysteine21.6VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
42cerebrovascular accident21.3VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
43primary biliary cirrhosis21.2UCP2, CETP, INS, IL1B, IL1RN, IL6
44hyperlipidemia20.4VWF, SELP, SERPINC1, SERPINE1, LPA, VCAM1
45dementia20.2VWF, SELP, SERPINC1, SERPINE1, LPA, VCAM1
46aortic aneurysm19.5VWF, SELE, SERPINC1, SERPINE1, LPA, BHMT
47schizophrenia19.5SELE, BCHE, UCP2, MTRR, MTHFR, MTR
48retinitis18.4VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
49nephropathy18.0VWF, SELE, SELP, SERPINE1, LPA, VCAM1
50multiple sclerosis17.4VWF, SELE, SELP, SERPINC1, SERPINE1, VCAM1

Graphical network of the top 20 diseases related to hyperhomocysteinemia:



Graphical network of diseases related to hyperhomocysteinemia

Clinical Features for Hyperhomocysteinemia

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Drugs & Therapeutics for Hyperhomocysteinemia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Genetic Tests for Hyperhomocysteinemia

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Anatomical Context for Hyperhomocysteinemia

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22MalaCards
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MalaCards organs/tissues related to hyperhomocysteinemia:

22
Brain, Heart, Kidney, Liver, Monocytes, T cells, B cells, Endothelial, Fetal brain, Cardiac myocytes, Fetal liver

Phenotypes for genes affiliated with Hyperhomocysteinemia

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25MGI
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MGI Mouse Phenotypes related to hyperhomocysteinemia:

25 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.3GGT1, SLC19A1, GJA5, GJA1
2respiratory system phenotypeMP:000538810.1ELN, GJA5, CBS, APOE, FBN1, ITGB3
3embryogenesis phenotypeMP:00053809.9TXN2, COMT, G6PD, DNMT1, SLC19A1, H19
4pigmentation phenotypeMP:00011869.1SOD2, DNMT1, PTEN, CASR, CCL2, APOE
5integument phenotypeMP:00107719.0F2, CBS, CASR, DNMT1, CSF3, SLC19A1
6renal/urinary system phenotypeMP:00053678.8PTEN, CTH, NOS3, AGTR1, SOD2, SLC19A1
7other phenotypeMP:00053958.7SOD2, NOS3, GJA1, CASR, HSPG2, APP
8hematopoietic system phenotypeMP:00053978.6GNMT, CASR, HRG, GJA1, RHD, EIF2S1
9reproductive system phenotypeMP:00053898.5F8, CBS, GJA1, GJA5, COMT, SOD2
10liver/biliary system phenotypeMP:00053708.3IL6, SLC19A1, H19, EPO, SOD1, SHMT1
11digestive/alimentary phenotypeMP:00053818.1GJA5, PTEN, PLAT, NOS3, EDN1, DNMT1
12immune system phenotypeMP:00053878.0SLC19A1, ADPRH, GGT1, VWF, CBS, HSPG2
13nervous system phenotypeMP:00036317.8F2, HSPG2, TXN2, PTEN, COMT, EDN1
14hearing/vestibular/ear phenotypeMP:00053777.2PPARG, PLAT, EDN1, SOD1, SOD2, GJA1
15skeleton phenotypeMP:00053907.0GJA1, PTEN, PPARG, PLAT, SOD3, H19
16adipose tissue phenotypeMP:00053757.0IGF1, PTEN, PPARG, NOS3, ACE, SOD2
17growth/size phenotypeMP:00053786.9ITGB3, FOLR1, INS, IL18, IL6, FBN1
18normal phenotypeMP:00028736.5ALB, GJA1, GJA5, PTEN, PPARG, THBD
19behavior/neurological phenotypeMP:00053866.4CTH, PTEN, GJA1, CASR, HSPG2, PPARG
20tumorigenesisMP:00020066.0GNMT, CAT, PTEN, PPARG, SHMT1, ACE
21vision/eye phenotypeMP:00053916.0SELE, SELP, SERPINC1, CHUK, LCAT, MTHFR
22muscle phenotypeMP:00053695.5NOS3, PLAT, PPARG, CTH, DDAH1, PTEN
23mortality/agingMP:00107684.6VCAM1, BCHE, CHUK, UCP2, MTHFR, MTR
24cellular phenotypeMP:00053843.4VWF, SELE, SELP, VCAM1, CHUK, UCP2
25homeostasis/metabolism phenotypeMP:00053762.7HRG, EDN1, EIF2S1, ELN, G6PD, TTR
26cardiovascular system phenotypeMP:00053852.7SOD2, CST3, PON1, NPPB, H19, EPO

Publications for genes affiliated with Hyperhomocysteinemia

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35PubMed
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Articles related to hyperhomocysteinemia:

(show top 50)    (show all 298)
idTitleAuthorsYearAffiliating Genes
1The nutrigenetics of hyperhomocysteinemia: quantitati ve proteomics reveals differences in the methionine cycle enzymes of gene-induc ed versus diet-induced hyperhomocysteinemia. (20008833)DiBello P.M.... Jacobsen D.W.2010CBS, BHMT, GNMT
2Hyperhomocysteinemia is associated with liver steato sis in patients with chronic hepatitis C. (21051057)FernA!ndez-Miranda C.... Castellano G.2010MTHFR
3Association of hyperhomocysteinemia with left ventric ular dilatation and mass in human heart. (20148720)Alter P.... Maisch B.2010NPPB
4Decrease in serum protein carbonyl groups concentrati on and maintained hyperhomocysteinemia in patients undergoing bariatric surgery . (18830787)Sledzinski T.... Swierczynski J.2009LSL
5Butyrylcholinesterase activity is reduced in haemodialysis patients: is there association with hyperhomocysteinemia and/or oxidative stress? (18237553)Garcia S.C.... Pomblum V.J.2008BCHE, ALAD
6Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis. (18080853)Russo C.... Aguglia U.2008MTHFR
7Severe atherosclerosis in rheumatoid arthritis and hyperhomocysteinemia: is there a link? (18457979)El Bouchti I.... Sibilia J.2008MTHFR
8Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice. (18454451)Gupta S.... Kruger W.D.2008CBS
9Relationship between hyperhomocysteinemia and C677T polymorphism of methylene tetrahydrofolate reductase gene in a healthy Algerian population (19091662)Hambaba L.... Rouabah F.2008MTHFR
10Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients. (17914182)Caccamo D.... Calabresi P.2007MTHFR
11Proton MR spectroscopy in hyperhomocysteinemia with elevated blood methionine levels. (16463305)Franco L.P.... Barker P.B.2006CBS
12Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. (17045925)Dai J.... Wang X.2006APEX1, CCL2
13Adaptive-outward and maladaptive-inward arterial remo deling measured by intravascular ultrasound in hyperhomocysteinemia and diabete s. (16703221)Reddy H.K.... Tyagi S.C.2006PPARG
14Mild hyperhomocysteinemia and the common C677T polymorphism of methylene tetrahydrofolate reductase gene are not associated with the metabolic syndrome in Type 2 diabetes. (16682831)Russo G.T.... Cucinotta D.2006MTHFR
15Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study. (16634748)Oger E.... Mottier D.2006MTHFR
16antiphospholipid antibodies syndrome associated with hyperhomocysteinemia related to MTHFR Gene C677T and A1298C heterozygous mutations in a young man with idiopathic hypoparathyroidism (DiGeorge syndrome). (16595601)Nucera C.... Vermiglio F.2006MTHFR
17Promoters of genes MTHFR from patients with hyperhomocysteinemia and PTEN from patients with malignant and benign endometrial and ovarian tumors (16909866)Kovalenko T.F.... Patrushev L.I.2006PTEN, MTHFR
18Splenic thrombosis in three patients with moderate hyperhomocysteinemia, low folate and the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene. (16411416)Starakis I.... Karatza C.2005MTHFR
19Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. (15834927)Adinolfi L.E.... Ruggiero G.2005MTHFR
20A proinflammatory state is associated with hyperhomocysteinemia in the elderly. (16087976)Gori A.M.... Ferrucci L.2005IL1R1, IL1RN
21Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia. (16197288)Riksen N.P.... Smits P.2005AHCY
22Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects. (15820491)Helfenstein T.... Izar M.C.2005MTR, MTHFR, MS
23Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap. (12765841)Harvey Mudd S.... Borschel M.W.2003CBS
24Hyperhomocysteinemia as an independent risk factor fo r silent brain infarction. (14663048)Kim N.K.... Choi K.G.2003MTHFR
25Interaction of CA repeat polymorphism of the endothelial nitric oxide synthase and hyperhomocysteinemia in acute coronary syndromes: evidence of gender-specific differences. (12684755)Laule M.... Stangl V.2003NOS3
26Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia. (14698652)Shmeleva V.M.... Savidge G.F.2003MTHFR
27Hyperhomocysteinemia and protein damage in chronic renal failure and kidney transplant pediatric patients--Italian initiative on uremic hyperhomocysteinemia (IIUH). (14696753)Perna A.F.... De Santo N.G.2003ICMT
28Effect of hyperhomocysteinemia on protein C activation and activity. (12200374)Lentz S.R.... Heistad D.D.2002CBS, PROC, F5
29Recurrent leg ulcers in a young man with hyperhomocysteinemia, factor V Leiden and impaired fibrinolysis. (12013200)Kolbach D.N.... Neumann H.A.2002F5
30Heterozygous methylene tetrahydrofolate reductase mutation with mild hyperhomocysteinemia associated with deep vein thrombosis. (12803132)Pathare A.... Murlitharan S.2002MTHFR
31The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs. (12399074)Apeland T.... Strandjord R.E.2002VWF, SELP
32Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia, and cardiovascular diseases in chronic hemodialysis patients. (11744804)Morimoto K.... Kikuchi K.2002NOS3, MTHFR
33Cerebral vein thrombosis and mild hyperhomocysteinemia: three new cases. (12522678)Rigamonti A.... Bussone G.2002MTHFR
34Methylenetetrahydrofolate reductase gene mutation and hyperhomocysteinemia as a risk factor for coronary heart disease in the Indian population. (12186157)Nair K.G.... Eghlim F.F.2002CBS, MTHFR
35High cysteine levels in renal transplant recipients: relationship with hyperhomocysteinemia and 5,10-MTHFR polymorphism. (11330536)Marcucci R.... Salvadori M.2001MTHFR
36Metabolic consequences of hyperhomocysteinemia in uremia. (11576929)Perna A.F.... De Santo N.G.2001ALB, ICMT
37Homozygous VN (677C to T) and d/D (2756G to A) variants in the methylenetetrahydrofolate and methionine synthase genes in a case of hyperhomocysteinemia with stroke at young age. (11460881)Song K.S.... Kim J.H.2001MTR, MTHFR
38Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia. (11343335)Szczeklik A.... Tendera M.2001MTHFR
39Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. (11011851)Yap S.... Boers G.H.2000CBS
40The effect of C677T mutation of methylene tetrahydrofolate reductase gene and plasma folate level on hyperhomocysteinemia in patients with meningomyelocele. (11048629)Lee B.H.... Wang K.C.2000MTHFR
41Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status. (10830195)Cardo E.... Vilaseca M.A.2000MTHFR
42Hyperhomocysteinemia in end-stage renal failure. (11379482)Kes P.2000THBD
43Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. (11092759)Devlin A.M.... Halsted C.H.2000FOLH1
44The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. (10780318)D'Angelo A.... Cerbone A.M.2000MTR, MTHFR
45Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults. (10662744)Chao C.L.... Lee Y.T.2000SELP
46Intermediate and severe hyperhomocysteinemia with thrombosis: a study of genetic determinants. (10780316)Gaustadnes M.... Ingerslev J.2000CBS
47Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency. (8561060)Guttormsen A.B.... Refsum H.1996MTR
48Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease. (8544771)Munshi M.N.... Fonseca V.1996INS
49Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. (7574192)Fermo I.... D'Angelo A.1995SERPINC1, F5
50Hyperhomocysteinemia in premature arterial disease: examination of cystathionine beta-synthase alleles at the molecular level. (7633411)Kozich V.... Kraus J.P.1995CBS

Expression for genes affiliated with Hyperhomocysteinemia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Hyperhomocysteinemia

Pathways for genes affiliated with Hyperhomocysteinemia

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34PharmGKB, 10EMD Millipore, 41Thomson Reuters, 20KEGG, 36QIAGEN, 37R&D Systems
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Pathways related to hyperhomocysteinemia according to GeneDecks:

(show top 50)    (show all 63)
idPathwayScoreTop Affiliating Genes
1Antimetabolite Pathway - Folate Cycle, Pharmacodynamics3410.8TYMS, SHMT1, CBS, MTHFD1, MTR, MTHFR
2Methionine metabolism1010.8DNMT1, AHCY, CTH, CBS, MTR, BHMT
3Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics3410.8TYMS, AHCY, SHMT1, CBS, MTHFD1, MTR
4Methotrexate Pathway (Cancer Cell), Pharmacodynamics3410.8SLC19A1, TYMS, SHMT1, CBS, MTHFD1, MTR
5Methionine metabolism4110.8DNMT1, CTH
6Cysteine and methionine metabolism2010.7DNMT1, AHCY, CTH, CBS, MTR, BHMT
7Glycine, serine and threonine metabolism2010.7SHMT1, CTH, CBS, GNMT, MAOB, BHMT
8One carbon pool by folate2010.7TYMS, SHMT1, ALDH1L1, MTHFD1, MTR, MTHFR
9Intrinsic Prothrombin Activation Pathway3610.6PROC, THBD, F2, F5, F8, F9
10Vitamin digestion and absorption2010.5SLC19A1, TCN2, APOB, APOA1, FOLH1
11Selected targets of C/EBPalpha1010.4ALB, F9, APOB, CETP, SERPINC1
12Warfarin Pathway, Pharmacodynamics3410.4PROC, F2, F7, F9
13Pathway_PA1659803373410.4SOD1, CAT, GPX1, GSR
14Oxidative Stress Pathway (Erythrocyte)3410.4SOD1, CAT, GPX1, GSR
15Oxidative Stress Pathway (Erythrocyte)3410.4GSR, GPX1, CAT, SOD1
16Extrinsic Prothrombin Activation Pathway3610.3PROC, THBD, F2, F3, F5, F7
17ACE Inhibitor Pathway, Pharmacodynamics3410.3AGTR1
18Blood Coagulation Cascade3610.3PROC, THBD, F2, F3, F5, F7
19Doxorubicin Pathway (Cancer Cell), Pharmacodynamics3410.3GPX1, CAT, NOS3, SOD1
20Complement and coagulation cascades2010.2KNG1, VWF, SERPINC1, SERPINE1, FGB, F9
21Blood Coagulation Signaling Pathways3710.1KNG1, PROC, VWF, SERPINC1, SERPINE1, FGB
22Akt Signaling3610.0TIMP4, CCL2, IL6, IL18, CHUK
23PTEN Pathway369.7TIMP4, ELN, PPBP, PTEN, HSPG2, FBN1
24Selected targets of HNF1109.6PROC, CRP, ALB, F8, APOH, APOB
25Metabolic pathways209.6SHMT1, G6PD, AHCY, TYMS, DNMT1, PON1
26Immune response_Bacterial infections in normal airways419.5IL1R1, IL1B, CHUK
27African trypanosomiasis209.5APOA1, IL6, IL1B, IL18, VCAM1, SELE
28Molecular Mechanisms of Cancer369.5TIMP4, PPBP, PTEN, FBN1, IL6, IL1R1
29Regulation of eIF4 and p70S6K369.3ITGB3, IL18, IL6
30PGC1Alpha Pathway369.3IL8, IL1R1, IL1B, IL18
31NOD-like receptor signaling pathway209.1CCL2, IL8, IL6, IL1B, IL18, CHUK
32Malaria208.9CSF3, CCL2, IL8, IL6, IL1B, IL18
33Chagas disease (American trypanosomiasis)208.9ACE, CCL2, IL8, IL6, IL1B, CHUK
34Hematopoietic cell lineage208.9EPO, CSF3, GP1BA, GP5, IL6, IL1R1
35Endothelin-1 Signaling Pathway368.8CSF3, EDN1, IL6, IL1B, IL18
36ERK Signaling368.8CSF3, TIMP4, PPBP, HSPG2, FBN1, IL6
37Selected targets of GCR-alpha108.7THBD, ELN, IL8, IL6, IL1B, INS
38Immune response IL-1 signaling pathway108.6EDN1, F3, IL8, IL6, IL1R1, IL1B
39Immune response_IL-1 signaling pathway418.6EDN1, F3, IL8, IL6, IL1R1, IL1B
40Renin-Angiotensin Pathway368.4TIMP4, AGTR1, ACE, PPBP, IGF1, CCL2
41PEDF Induced Signaling368.3CSF3, SOD2, CCL2, IL8, IL6, IL1B
42NF-KappaB (p50-p65) Pathway367.8TIMP4, PPBP, IGF1, IL6, IL1R1, IL1B
43TGF-Beta Pathway367.7CCL2, IGF1, PPBP, TIMP4, IL8, IL6
44Rho Family GTPases367.6HSPG2, PPBP, ELN, TIMP4, CSF3, IGF1
45MAPK Family Pathway367.5TIMP4, PPBP, IGF1, CCL2, IL8, IL6
46PAK Pathway367.4CSF3, TIMP4, PPBP, IGF1, CCL2, IL8
47MAPK Signaling367.4IGF1, HSPG2, PPBP, ELN, TIMP4, FBN1
48Tec Kinases Signaling367.3TIMP4, PPBP, IGF1, CCL2, IL8, IL6
49JAK-STAT Pathway367.3F2, F2RL2, PPBP, AGTR1, TIMP4, EPO
50Antioxidant Action of Vitamin-C367.2CCL2, IGF1, PPBP, TIMP4, CSF3, IL8

Compounds for genes affiliated with Hyperhomocysteinemia

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32Novoseek , 9DrugBank, 34PharmGKB, 42Tocris Bioscience, 18HMDB
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Compounds related to hyperhomocysteinemia according to GeneDecks:

(show top 50)    (show all 591)
idCompoundScoreTop Affiliating Genes
1hirudin32 10.7SERPINC1, THBD, F5, F9, GP1BA, FGB
2phosphatidylserine32 9 9 12.6VWF, SELE, THBD, F2, F5, F9
3cyclophosphamide32 34 9 9 13.6NPPB, F8, F9, APOH
4tranexamic acid32 9 9 12.6EPO, PLAT, F8, F9, LPA, SERPINE1
5vitamin b632 10.1MTHFR, BHMT, MTR, MTHFD1, GSR, EPO
6desmopressin32 42 9 9 13.1EPO, THBD, PLAT, PPBP, F2, F3
7isoproterenol32 9 9 12.0COMT, GJA1, APP, FGF2, UCP2
8perindopril32 34 9 9 13.0SERPINE1, VWF, BCHE, ALB, CRP, KNG1
9hyaluronic acid32 18 11.0GGT1, THBD, TTR, ELN, PPBP, PTEN
10sodium nitroprusside32 9.8KNG1, NPPB, AGTR1, G6PD, ELN, CAT
11polysaccharide32 9.8SELP, SELE, TYMS, ELN, RHD, F3
12palmitate32 9.8EIF2S1, RHD, PLAT, PPARG, HSPG2, APOA1
13aprotinin32 9 9 11.6GP1BA, SERPINC1, SELP, VWF, IGF1, F9
14ethanol32 34 9 18 9 13.6GGT1, CPOX, SLC19A1, PON1, AGTR1, LSL
15pioglitazone32 9 9 11.5INS, VCAM1, GSR, APOA1, APOB, NPPB
16ramipril32 9 9 11.4KNG1, NPPB, CST3, AGTR1, ACE, CRP
17cysteine32 9.2ADPRH, SLC19A1, CASR, ALB, ICMT, MAOB
18captopril32 42 9 9 12.1KNG1, NPPB, CST3, SOD2, ACE, ALB
19vitamin a32 9 18 9 12.0GSR, CETP, LCAT, VWF, APOB, APOE
20valine32 9.0GP1BA, APP, APOH, APOE, CETP, MTR
21bezafibrate32 9 9 11.0GGT1, CRP, PPARG, APOE, APOB, APOA1
22malondialdehyde32 9.0GSR, LPA, PON1, SOD3, SOD2, SOD1
23betacarotene32 9.0GGT1, PON1, SOD2, SOD1, THBD, TTR
24sulfasalazine32 9 9 10.9SLC19A1, CRP, PPARG, CCL2, IL8, IL1RN
25histamine32 18 9.8PPBP, HSPG2, ALB, CCL2, MAOB, IL1RN
26fenofibrate32 9 9 10.6SELE, SELP, SERPINE1, LPA, PON1, NOS3
27menadione32 9 18 9 11.6GGT1, SOD2, SOD1, PROC, TXN, CAT
28doxorubicin32 34 9 9 11.6CAT, GPX1, CCNA2, IL18, GSR, FOLR1
29prednisolone32 9 9 10.5FGF2, VCAM1, VWF, IL18, IL1R1, IL1RN
30aspartate32 8.4CST3, SOD2, THBD, ELN, RHD, F2
31ibuprofen32 9 18 9 11.3F3, MAOB, APP, APOE, IL6, IL1RN
32oxygen32 18 9.2CPOX, NPPB, SOD3, DNMT1, APEX1, FBN1
33losartan32 34 9 9 11.1KNG1, NPPB, SOD3, SELP, SELE, VWF
348-isoprostane32 8.1IL8, IL6, INS, VCAM1, SERPINE1, SELE
35metformin32 34 9 9 10.9GGT1, ACE, LSL, CRP, PPARG, F5
36testosterone32 9 18 9 10.9APP, APOE, APOA1, IL1RN, IL1R1, IL18
37cisplatin32 34 9 9 10.8GJA1, CCL2, CCNA2, APEX1, IL1R1, IL18
38alpha tocopherol32 7.8VCAM1, CAT, ALB, IGF1, GPX1, MAOB
39iron32 18 8.8GGT1, EPO, CPOX, NPPB, CST3, SOD3
40heparin32 9 18 9 10.7KNG1, SOD3, SOD2, APOB, APEX1, FBN1
41tamoxifen32 34 9 9 10.7LSL, SELE, SERPINC1, VCAM1, CHUK, COMT
42ly29400232 7.6SOD2, EIF2S1, CRP, GJA1, CCL2, CCNA2
43prostacyclin32 7.5NOS3, PLAT, CRP, PPBP, PPARG, HSPG2
44aspirin32 34 18 9.2F3, F5, F8, GP1BA, GP5, APP
45cyclosporin a32 42 8.0NPPB, CST3, SOD2, THBD, IL18, FGF2
46nitric oxide32 9 18 9 9.9KNG1, CPOX, NPPB, SOD3, THBD, ACE
47indomethacin32 9 9 8.7GGT1, APOA1, IL6, IL1RN, IL1R1, IL1B
48tyrosine32 4.5SELP, VWF, EPO, H19, KNG1, NPPB
49dexamethasone32 42 34 9 9 7.5MAOB, SERPINC1, SELP, VWF, SERPINE1, VCAM1
50vegf32 3.2EPO, PPBP, PPARG, PTEN, TXN, GJA1

GO Terms for genes affiliated with Hyperhomocysteinemia

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Sources:
12Gene Ontology
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Cellular components related to hyperhomocysteinemia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:03436410.1PON1, APOH, APOE, APOA1, CETP, LCAT
2extracellular matrixGO:0310129.9SOD3, SOD1, PLAT, HSPG2, F3, APOH
3very-low-density lipoprotein particleGO:0343619.9APOH, APOE, APOB, APOA1
4endoplasmic reticulum lumenGO:0057889.3F2, F7, F9, APOB, APOA1, INS
5platelet alpha granule lumenGO:0310939.2ALB, HRG, PPBP, KNG1, F5, F8
6Golgi lumenGO:0057969.1PROC, HSPG2, F2, F7, F9, INS
7cytosolGO:0058297.9PPARG, CTH, PTEN, TXN, GJA1, NOS3
8plasma membraneGO:0058866.6PTEN, GJA1, HRG, CASR, CAT, HSPG2
9extracellular regionGO:0055764.1VWF, IL1R1, IL6, IL8, FBN1, APOA1
10extracellular spaceGO:0056153.8SELE, IL6, IL8, FBN1, APOA1, APOB

Biological processes related to hyperhomocysteinemia according to GeneDecks:

(show top 50)    (show all 63)
idNameGO IDScoreTop Affiliating Genes
1sulfur amino acid metabolic processGO:00009610.9AHCY, CTH, CBS, MTR, BHMT
2methionine biosynthetic processGO:00908610.8MTHFD1, MTHFR, MTRR, BHMT
3negative regulation of fibrinolysisGO:05191810.7THBD, HRG, F2, APOH, SERPINE1
4folic acid metabolic processGO:04665510.7MTHFD1, FOLR1, SHMT1, SLC19A1, MTHFR
5negative regulation of platelet activationGO:01054410.7THBD, NOS3, F2, GP5, APOE
6fibrinolysisGO:04273010.6PLAT, HRG, F2, GP1BA, SERPINE1
7positive regulation of blood coagulationGO:03019410.6F2, F7, APOH, SERPINE1
8blood coagulation, intrinsic pathwayGO:00759710.6KNG1, F2, F8, F9, GP1BA, GP5
9peptidyl-glutamic acid carboxylationGO:01718710.5F9, F7, F2, PROC
10blood circulationGO:00801510.4LPA, ELN, EPO
11lipoprotein biosynthetic processGO:04215810.4APOB, APOA1, LCAT
12negative regulation of blood coagulationGO:03019510.4KNG1, PROC, THBD, EDN1, APOH, APOE
13high-density lipoprotein particle remodelingGO:03437510.4APOE, APOA1, CETP, LCAT
14blood coagulation, extrinsic pathwayGO:00759810.3F9, F7, F3
15glutathione metabolic processGO:00674910.3GGT1, SOD1, G6PD, CTH, GPX1, GSR
16triglyceride metabolic processGO:00664110.3CAT, GPX1, APOH, APOE, CETP
17response to organic cyclic compoundGO:01407010.3NPPB, COMT, NOS3, TXN2, F7, IL1RN
18reverse cholesterol transportGO:04369110.3LCAT, CETP, APOA1, APOE
19cholesterol transportGO:03030110.3APOB, APOA1, CETP, LCAT
20response to hyperoxiaGO:05509310.3EPO, NOS3, CAT, IL18, SERPINE1
21receptor-mediated endocytosisGO:00689810.1APOE, APOB, FOLR1, CETP, LPA
22lipoprotein metabolic processGO:04215710.0HSPG2, ALB, APOE, APOB, APOA1, CETP
23cholesterol metabolic processGO:00820310.0CAT, APOE, APOB, APOA1, CETP, LCAT
24negative regulation of macrophage derived foam cell differentiationGO:01074510.0CETP, ITGB3, PPARG, CRP
25blood vessel remodelingGO:00197410.0ELN, NOS3, CBS, IGF1
26response to lipopolysaccharideGO:0324969.8EDN1, TIMP4, THBD, EPO, COMT, F3
27regulation of blood pressureGO:0082179.7NPPB, SOD2, SOD1, ACE, NOS3, PPARG
28angiogenesisGO:0015259.7NOS3, PTEN, GJA5, HRG, HSPG2, CCL2
29response to drugGO:0424939.7COMT, EDN1, TIMP4, SOD1, NPPB, NOS3
30cellular response to tumor necrosis factorGO:0713569.7EDN1, CCL2, APOB, IL8, IL18
31protein homotetramerizationGO:0512899.6SOD2, SHMT1, CTH, CAT, GNMT
32heart developmentGO:0075079.6NPPB, EDN1, PPARG, PTEN, GJA1, FBN1
33negative regulation of smooth muscle cell apoptotic processGO:0343929.5EDN1, IGF1, APOH
34agingGO:0075689.5NOS3, F3, CCL2, IL1B, VCAM1, EPO
35response to glucocorticoid stimulusGO:0513849.5PLAT, CCL2, IL6, IL1RN, IL1B, LCAT
36positive regulation of angiogenesisGO:0457669.5NOS3, DDAH1, F3, IL1B, FGF2, SERPINE1
37negative regulation of lipid storageGO:0108889.4ITGB3, IL6, CRP
38lipid metabolic processGO:0066299.4G6PD, PPARG, HSPG2, ALB, APOE, APOB
39acute-phase responseGO:0069539.2CRP, F2, F8, IL6, IL1RN, INS
40response to hypoxiaGO:0016669.2PLAT, NOS3, EDN1, SOD3, NPPB, CRP
41platelet degranulationGO:0025769.1KNG1, VWF, SOD1, PPBP, HRG, ALB
42anti-apoptosisGO:0069169.0EPO, SOD1, NOS3, CTH, F3, F7
43positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140688.8CAT, F2, IGF1, INS, SELP
44inflammatory responseGO:0069548.7KNG1, NPPB, CRP, CCL2, IL8, IL6
45platelet activationGO:0301688.3PPBP, HRG, ALB, F2RL2, F2, F5
46negative regulation of apoptotic processGO:0430668.3PTEN, PROC, SOD2, EPO, CAT, ALB
47blood coagulationGO:0075968.3VWF, F8, F9, IGF1, GP1BA, GP5
48small molecule metabolic processGO:0442818.0CTH, PTEN, TXN, CAT, HSPG2, CBS
49negative regulation of cell proliferationGO:0082857.4SOD2, NOS3, CTH, PTEN, GJA1, HRG
50positive regulation of cell proliferationGO:0082846.8PTEN, EDN1, CSF3, EPO, F2, ICMT

Molecular functions related to hyperhomocysteinemia according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:00554210.5SLC19A1, GNMT, FOLR1, MTR
2beta-amyloid bindingGO:00154010.3BCHE, APOA1, APOE, CST3
3eukaryotic cell surface bindingGO:04349910.2EPO, APOH, FGB, SELP
4NADP bindingGO:05066110.0G6PD, NOS3, CAT, GSR, MTRR
5heparin bindingGO:0082019.8SELP, KNG1, SOD3, HRG, CCL2, APP
6protease bindingGO:0020209.6CST3, F3, IL1R1, INS, SERPINE1, SERPINC1
7receptor bindingGO:0051029.4KNG1, NPPB, GJA1, CAT, F2, F7
8enzyme bindingGO:0198999.2CSF3, PPARG, PTEN, CAT, CBS, APOB
9protein homodimerization activityGO:0428039.1SHMT1, G6PD, SOD1, PON1, CPOX, CRP
10hormone activityGO:0051798.5EPO, NPPB, TTR, EDN1, IGF1, INS
11protein bindingGO:0055153.9CTH, PPARG, CRP, PLAT, NOS3, PTEN

Sources for Hyperhomocysteinemia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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