MCID: HYP037
MIFTS: 49

Hyperhomocysteinemia

Categories: Metabolic diseases

Aliases & Classifications for Hyperhomocysteinemia

MalaCards integrated aliases for Hyperhomocysteinemia:

Name: Hyperhomocysteinemia 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9279
MeSH 42 D020138
NCIt 47 C84770
SNOMED-CT 64 419503008
UMLS 69 C0598608

Summaries for Hyperhomocysteinemia

Disease Ontology : 12 An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood.

MalaCards based summary : Hyperhomocysteinemia is related to homocystinuria and budd-chiari syndrome. An important gene associated with Hyperhomocysteinemia is MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase), and among its related pathways/superpathways are Metabolism and Carbon metabolism. The drugs Hydroxocobalamin and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and kidney, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Wikipedia : 72 Hyperhomocysteinemia or hyperhomocysteinaemia is a medical condition characterized by an abnormally high... more...

Related Diseases for Hyperhomocysteinemia

Diseases related to Hyperhomocysteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
id Related Disease Score Top Affiliating Genes
1 homocystinuria 30.5 CBS MTHFR MTR
2 budd-chiari syndrome 29.8 F5 MTHFR SERPINC1
3 neural tube defects 28.2 BHMT CBS CCL2 FOLH1 MTHFR MTR
4 peripheral artery disease 26.3 ALB APOE CCL2 MTHFR NOS3 PON1
5 myocardial infarction 25.4 ALB APOE CBS CCL2 F5 MTHFR
6 multicentric osteolysis nephropathy 10.8 F5 MTHFR
7 homocystinuria, b6-responsive and nonresponsive types 10.8
8 mthfr thermolabile variant 10.8
9 congenital intrinsic factor deficiency 10.8 MTR MTRR
10 x-linked disease 10.8 MTR MTRR
11 homocystinuria due to mthfr deficiency 10.7 CBS MTHFR MTR
12 hypertonia 10.7 MTHFR NOS3
13 neural tube defects, folate-sensitive 10.6 MTHFR MTR MTRR
14 factor v leiden thrombophilia 10.6 MTR MTRR
15 agammaglobulinemia 2 10.6 MTHFR MTR MTRR
16 pregnancy loss, recurrent 1 10.6 F5 MTHFR
17 syncope 10.6 F5 MTHFR SERPINC1
18 superior limbic keratoconjunctivitis 10.6 F5 MTHFR SERPINC1
19 follicular adenoma 10.6 F5 MTHFR SERPINC1
20 fragile x syndrome type 2 10.6 ALB SERPINC1
21 ehlers-danlos syndrome, type viic 10.6 MTHFR MTR MTRR
22 hiv-1 10.6 F5 MTHFR SERPINC1
23 femoral neuropathy 10.5 F5 MTHFR SERPINC1
24 angular blepharoconjunctivitis 10.5 F5 MTHFR SERPINC1
25 blepharoconjunctivitis 10.5 F5 MTHFR SERPINC1
26 vaginal glandular tumor 10.5 MTHFR MTR MTRR
27 testicular gonadoblastoma 10.5 F5 SERPINC1
28 hepatocellular adenoma 10.5 F5 MTHFR NOS3
29 necrotic uveal melanoma 10.5 F5 MTHFR SERPINC1
30 dentine erosion 10.5 F5 MTHFR SERPINC1
31 bernard-soulier syndrome, type a2 10.5 MTHFR NOS3 SERPINC1
32 ectopic pregnancy 10.4 CBS MTHFR MTR MTRR
33 exophthalmic ophthalmoplegia 10.4 ALB F5 SERPINC1
34 candidiasis, familial, 6, autosomal dominant 10.4 CBS MTHFR
35 cataract 10.4 ALB SERPINC1
36 myxomatous pattern testicular yolk sac tumor 10.4 F5 NOS3 THBD
37 interval angle-closure glaucoma 10.4 CCL2 NOS3
38 neuromyelitis optica 10.4 MTHFR SERPINE1
39 methylmalonic aciduria and homocystinuria type cblg 10.4 MTHFR MTR PON1
40 orbital disease 10.4 MTHFR MTR MTRR
41 perichondritis of auricle 10.3 F5 SERPINC1 THBD
42 megacolon 10.3 CBS MTHFR
43 thrombosis 10.3
44 aryepiglottic fold cancer 10.3 ALB F5 MTHFR SERPINC1
45 lymphatic system cancer 10.3 FOLH1 MTHFR SERPINC1 THBD
46 coronary sinus stenosis 10.3 F5 MTHFR SERPINE1
47 joint disorders 10.3 F5 MTHFR NOS3 SERPINC1
48 amelogenesis imperfecta hypomaturation type 10.2 F5 MTHFR SERPINE1
49 lockwood feingold syndrome 10.2 F5 MTHFR SERPINE1
50 ulcerative stomatitis 10.2 F5 MTHFR SERPINC1 THBD

Graphical network of the top 20 diseases related to Hyperhomocysteinemia:



Diseases related to Hyperhomocysteinemia

Symptoms & Phenotypes for Hyperhomocysteinemia

GenomeRNAi Phenotypes related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.8 APOE F5 FOLH1

MGI Mouse Phenotypes related to Hyperhomocysteinemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 F5 MTHFR MTR MTRR NOS3 PON1
2 liver/biliary system MP:0005370 9.81 ALB APOE BHMT CTH F5 NOS3
3 mortality/aging MP:0010768 9.7 AHCY ALB APOE CTH F5 MTHFR
4 renal/urinary system MP:0005367 9.23 ALB APOE BHMT CTH NOS3 SERPINC1

Drugs & Therapeutics for Hyperhomocysteinemia

Drugs for Hyperhomocysteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
2
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
3
Enalapril Approved, Vet_approved Phase 4,Phase 2,Phase 3 75847-73-3 5362032 40466924
4
Enalaprilat Approved Phase 4,Phase 2,Phase 3 76420-72-9 6917719
5
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-05-9 143 6006
8
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 68-19-9 44176380
9
Maleic acid Experimental Phase 4,Phase 2,Phase 3 110-16-7 444266
10 Hematinics Phase 4,Phase 2,Phase 3,Phase 1
11 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
12 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
13 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1
14 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
15 Vitamin B 12 Phase 4,Phase 3,Phase 2
16 Antihypertensive Agents Phase 4,Phase 2,Phase 3
17 calcium channel blockers Phase 4,Phase 2,Phase 3
18 Calcium, Dietary Phase 4,Phase 2,Phase 3
19 Vasodilator Agents Phase 4,Phase 2,Phase 3
20 Neurotransmitter Agents Phase 4,Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2,Phase 3
22 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
23
protease inhibitors Phase 4,Phase 2,Phase 3
24 Adrenergic Agents Phase 4
25 Adrenergic Antagonists Phase 4
26 Adrenergic beta-Antagonists Phase 4
27 diuretics Phase 4
28 Natriuretic Agents Phase 4
29 Sodium Chloride Symporter Inhibitors Phase 4
30 Folate Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
31 Vitamin B9 Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
32
Cobalamin Nutraceutical Phase 4,Phase 3,Phase 2 13408-78-1 6438156
33
Methylcobalamin Experimental, Nutraceutical Phase 4,Phase 3,Phase 2 13422-55-4
34 Vitamin B12 Nutraceutical Phase 4,Phase 3,Phase 2
35
Hydroquinone Approved Phase 3 123-31-9 785
36
Pyridoxal Approved, Nutraceutical Phase 3,Phase 2 66-72-8 1050
37
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 65-23-6 1054
38
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
39
Betaine Approved, Nutraceutical Phase 3,Phase 2 107-43-7 247
40
Choline Approved, Nutraceutical Phase 3 62-49-7 305
41
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
42 Antioxidants Phase 3,Phase 2
43 Protective Agents Phase 3,Phase 2,Phase 1
44 Radiation-Protective Agents Phase 3
45 Vitamin B 6 Phase 3,Phase 2
46 Antimetabolites Phase 3,Phase 2
47 Gastrointestinal Agents Phase 3,Phase 2
48 Hypolipidemic Agents Phase 3,Phase 2
49 Lipid Regulating Agents Phase 3,Phase 2
50 Nootropic Agents Phase 3

Interventional clinical trials:

(show all 43)

id Name Status NCT ID Phase Drugs
1 Uremic Hyperhomocysteinemia -A Folate Trial for Possible Prevention of Cardiovascular Events Completed NCT00317005 Phase 4 folate treatment
2 Effect of Folic Acid Supplementation on Plasma Homocysteine Level in Obese Children Completed NCT01766310 Phase 4 Folic Acid;placebo
3 The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia. Completed NCT00165711 Phase 4 Mecobalamin
4 Can Oral Vitamin B12 and Folate Supplementation Preserve Cognitive Function of Patients With Early Dementia? Completed NCT00164970 Phase 4
5 Feasibility Study of the Intensive Systolic Blood Pressure Control Enrolling by invitation NCT02817503 Phase 4 Standard BP control;Moderate BP control;Intensive BP control
6 CSPPT- Chronic Kidney Diseases Study Withdrawn NCT01871740 Phase 4 Enalapril maleate and folic acid tablets;Enalapril maleate
7 Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine Unknown status NCT01848873 Phase 2, Phase 3 Amlodipine;amlodipine-FA tablet, low dose group;amlodipine-FA tablet ,high dose group
8 Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine Unknown status NCT01956786 Phase 2, Phase 3 Amlodipine-FA tablet,low dose group;Amlodipine-FA tablet,high dose group;Amlodipine
9 Effects of Low-dose Complex B-vitamins on Homocysteine and Framingham Risk Score Among Chinese Elderly Completed NCT00755664 Phase 3
10 The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy Volunteers Completed NCT01371357 Phase 3 TEST 1;TEST 2;TEST 3;TEST 4
11 Vitamin B6 Effects for Women Taking Birth Control Pills Completed NCT01128244 Phase 2, Phase 3
12 The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment Recruiting NCT02575092 Phase 2, Phase 3 Enalapril Maleate Tablets(as the program-based antihypertension);Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension);Placebo
13 EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment Completed NCT01793090 Phase 2 Epi-743
14 Homocystinuria: Treatment With N-Acetylcysteine Completed NCT00483314 Phase 2 N-acetylcysteine
15 Betaine METABOLISM OF PATIENTS With Homocystinuria Recruiting NCT02404337 Phase 2 Betaine
16 Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine Active, not recruiting NCT01192828 Phase 1, Phase 2 taurine
17 Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine Completed NCT00473200 Phase 1
18 Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns Completed NCT00877227 Phase 1 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv)
19 A Retrospective Analysis of Cerefolin NAC® in Cognitively Impaired Patients Unknown status NCT01594541
20 The Impact of EDCs Relative Markers and Reproductive Hormone in Taiwanese Women Unknown status NCT01996631
21 Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients Completed NCT01391416
22 Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis Completed NCT00004495 cyanocobalamin;folic acid;pyridoxine
23 The Effect of Folic Acid Administration in the Progression of Microalbuminuria Completed NCT00737126 Folic acid;Placebo
24 Effects of Oral Supplementation With Creatine on Systemic Microvascular Endothelial Function in Vegetarian Individuals Completed NCT02961972
25 Plasma Homocysteine Distribution in the United States Completed NCT00005483
26 Effect of Vitamin B12 Supplementation on Glycaemic Control in Uncontrolled Hyperhomocysteinemic Type 2 Diabetic Patients Completed NCT02540642
27 Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function Completed NCT02392767
28 Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial Completed NCT01661309
29 5-Methyltetrahydrofolate Survival and Inflammation in ESRD Patients Completed NCT00626223 5-MTHF (5-methyltetrahydrofolate);folic acid
30 Methylation Biosignature in Childhood Chronic Kidney Disease Completed NCT02022046
31 Effect of 1 Year Vitamin D or D Plus B-vitamins on Bone Markers in Elderly People (KnoVIB) Completed NCT02586181
32 Plasma Vitamin and Homocysteine Levels and Thrombosis in Patients With Ph-negative MPNs Completed NCT01878916
33 NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support) Completed NCT01370954
34 COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE Completed NCT02860338
35 Role of Systemic Inflammation in Increase of Cardio-vascular Risk in Chronic Obstructive Pulmonary Disease Completed NCT02888886
36 The Association of Ferrtin and Homocysteine Etc. With RI and MS in Polycystic Ovary Syndrome (PCOS) Completed NCT01600833
37 Homocyst(e)Ine, Vitamin Status, and CVD Risk Completed NCT00005482
38 Homocysteine and Progression of Atherosclerosis Completed NCT00005338
39 Study of Chronic Degenerative Diseases Completed NCT02495961
40 Study of Homocysteine Metabolism in Homocystinuria Completed NCT00004356
41 The Application of Digital Infrared Thermal Imaging in Peripheral Artery Disease of the Lower Extremities Recruiting NCT02783677
42 Clinical and Laboratory Study of Methylmalonic Acidemia Recruiting NCT00078078
43 Natural History Study of Cystathionine Beta-synthase Deficiency Homocystinuria (CBSDH) Recruiting NCT02998710

Search NIH Clinical Center for Hyperhomocysteinemia

Cochrane evidence based reviews: hyperhomocysteinemia

Genetic Tests for Hyperhomocysteinemia

Genetic tests related to Hyperhomocysteinemia:

id Genetic test Affiliating Genes
1 Hyperhomocysteinemia 29

Anatomical Context for Hyperhomocysteinemia

MalaCards organs/tissues related to Hyperhomocysteinemia:

39
Endothelial, Brain, Kidney, Bone, Heart, Liver, Ovary

Publications for Hyperhomocysteinemia

Articles related to Hyperhomocysteinemia:

(show top 50) (show all 880)
id Title Authors Year
1
Efficacy of Folic Acid Therapy in Patients with Hyperhomocysteinemia. ( 28854002 )
2017
2
Calcium sensing receptor initiating cystathionine-gamma-lyase/hydrogen sulfide pathway to inhibit platelet activation in hyperhomocysteinemia rat. ( 28633902 )
2017
3
Comparison of oxidative stress biomarkers in hypertensive patients with or without hyperhomocysteinemia. ( 28920709 )
2017
4
Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms. ( 28901725 )
2017
5
A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia. ( 28912716 )
2017
6
Effects of atorvastatin and simvastatin on oxidative stress in diet-induced hyperhomocysteinemia in Wistar albino rats: a comparative study. ( 28620818 )
2017
7
Hyperhomocysteinemia as a Metabolic Risk Factor for Glucose Intolerance Among High-Risk Groups of Chinese Adults. ( 28591087 )
2017
8
Associative role of TYMS6bpdel polymorphism and resulting hyperhomocysteinemia in the pathogenesis of preterm delivery and associated complications: A study from Northeast India. ( 28627444 )
2017
9
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia. ( 27901381 )
2017
10
Hyperhomocysteinemia and Age-related Macular Degeneration: Role of Inflammatory Mediators and Pyroptosis; A Proposal. ( 28735646 )
2017
11
Epidemiological characteristics of hyperhomocysteinemia and H-type hypertension in the elderly in Beijing, China. ( 28640642 )
2017
12
Ablation of Toll-like Receptor 4 Mitigates Cardiac Mitochondrial Dysfunction in Hyperhomocysteinemia. ( 28738166 )
2017
13
Hyperhomocysteinemia in Greyhounds and its Association with Hypofolatemia and Other Clinicopathologic Variables. ( 27864850 )
2017
14
Is hyperhomocysteinemia a causal factor for heart failure? The impact of the functional variants of MTHFR and PON1 on ischemic and non-ischemic etiology. ( 27863359 )
2017
15
Omega-3 PUFA ameliorates hyperhomocysteinemia-induced hepatic steatosis in mice by inhibiting hepatic ceramide synthesis. ( 28933423 )
2017
16
Therapeutic Potential of Progranulin in Hyperhomocysteinemia-Induced Cardiorenal Dysfunction. ( 27872232 )
2017
17
Ablation of Toll-like receptor 4 mitigates central blood pressure response during hyperhomocysteinemia. ( 28665886 )
2017
18
Venous thromboembolism and hyperhomocysteinemia as first manifestation of pernicious anemia: a case series. ( 28863787 )
2017
19
Is there a link between hyperhomocysteinemia and Vogt-Koyanagi-Harada syndrome? ( 28673567 )
2017
20
Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling. ( 28888894 )
2017
21
Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress. ( 28931831 )
2017
22
Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia. ( 28810641 )
2017
23
Ginkgo biloba extract EGb761 attenuates Hyperhomocysteinemia-induced AD like tau hyperphosphorylation and cognitive impairment in rats. ( 28847282 )
2017
24
Hyperhomocysteinemia as a Risk Factor for Saccular Intracranial Aneurysm: A Cohort Study in a Chinese Han Population. ( 28943219 )
2017
25
Severe Hyperhomocysteinemia Decreases Creatine Kinase Activity and Causes Memory Impairment: Neuroprotective Role of Creatine. ( 28656547 )
2017
26
Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID). ( 27890830 )
2017
27
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation. ( 28030819 )
2016
28
Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia. ( 27028508 )
2016
29
Relationship between lifestyle factors and hyperhomocysteinemia in general Chinese population: a cross-sectional study. ( 27797301 )
2016
30
L-DOPA-induced hyperhomocysteinemia in Parkinson's disease: Elephant in the room. ( 27318154 )
2016
31
To study the prevalence of coronary artery disease in end-stage renal disease and its correlation with hyperhomocysteinemia. ( 27727564 )
2016
32
CerefolinNAC Therapy ofA Hyperhomocysteinemia Delays Cortical and White Matter Atrophy in Alzheimer's Disease and Cerebrovascular Disease. ( 27567825 )
2016
33
Nitrative Stress Participates in Endothelial Progenitor Cell Injury in Hyperhomocysteinemia. ( 27391949 )
2016
34
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. ( 27349749 )
2016
35
Creatine supplementation prevents hyperhomocysteinemia, oxidative stress and cancer-induced cachexia progression in Walker-256 tumor-bearing rats. ( 26781304 )
2016
36
Association of Hyperhomocysteinemia with Stroke Recurrence after Initial Stroke. ( 27260368 )
2016
37
The Effect of Hyperhomocysteinemia on Motor Symptoms, Cognitive Status, and Vascular Risk in Patients with Parkinson's Disease. ( 27642535 )
2016
38
Impact of Genetic Polymorphism of methylenetetrahydrofolate reductase C677T on Development of Hyperhomocysteinemia and Related Oxidative Changes in Egyptian I^-Thalassemia Major Patients. ( 27187171 )
2016
39
The effect of levodopa benserazide hydrochloride on homocysteinemia levels in patients with Parkinson's disease and treatment of hyperhomocysteinemia. ( 27338068 )
2016
40
A case of hyperhomocysteinemia with retinitis pigmentosa - A rare presentation. ( 27728730 )
2016
41
Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review. ( 27908565 )
2016
42
Increased neutrophil to lymphocyte ratio in persons suffering from hypertension with hyperhomocysteinemia. ( 27009577 )
2016
43
Hyperhomocysteinemia Alters Sinoatrial and Atrioventricular Nodal Function: Role of Magnesium in Attenuating These Effects. ( 26972302 )
2016
44
High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia. ( 27689109 )
2016
45
Role of Hyperhomocysteinemia and Methylene Tetrahydrofolate Reductase C677T Polymorphism in Idiopathic Portal Vein Thrombosis. ( 27051654 )
2016
46
Hyperhomocysteinemia is associated with decreased apolipoprotein AI levels in normal healthy people. ( 26758372 )
2016
47
Relationship between cardio-ankle vascular index and homocysteine in hypertension subjects with hyperhomocysteinemia. ( 27653661 )
2016
48
The Effect of Folic Acid Supplementation on Hyperhomocysteinemia and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease: A Pilot Study. ( 28050421 )
2016
49
A case of vascular parkinsonism associated with hyperhomocysteinemia and methylenetetrahydrofolate reductase gene variant (C677T). ( 26797478 )
2016
50
High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease. ( 27775590 )
2016

Variations for Hyperhomocysteinemia

Expression for Hyperhomocysteinemia

Search GEO for disease gene expression data for Hyperhomocysteinemia.

Pathways for Hyperhomocysteinemia

Pathways related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 AHCY ALB APOE BHMT CBS CTH
2
Show member pathways
12.1 CBS CTH MTHFR MTR
3
Show member pathways
11.91 F5 SERPINC1 SERPINE1 THBD
4 11.77 F5 SERPINC1 SERPINE1 THBD
5 11.65 BHMT CBS CTH
6
Show member pathways
11.52 AHCY BHMT CBS CTH MTR MTRR
7 11.45 CCL2 NOS3 SERPINE1 THBD
8
Show member pathways
11.37 AHCY BHMT CBS CTH FOLH1 MTHFR
9
Show member pathways
11.32 BHMT CBS CTH
10 10.96 CCL2 NOS3 THBD
11 10.75 CTH MTR
12
Show member pathways
10.45 CBS MTHFR
13
Show member pathways
10.23 MTR MTRR

GO Terms for Hyperhomocysteinemia

Cellular components related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 AHCY ALB APOE BHMT CTH FOLH1
2 endoplasmic reticulum lumen GO:0005788 9.56 ALB APOE F5 SERPINC1
3 extracellular space GO:0005615 9.56 ALB APOE CCL2 F5 PON1 SERPINC1
4 platelet alpha granule lumen GO:0031093 9.33 ALB F5 SERPINE1
5 blood microparticle GO:0072562 8.92 ALB APOE PON1 SERPINC1

Biological processes related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.93 ALB APOE F5 SERPINC1
2 cellular protein metabolic process GO:0044267 9.87 ALB APOE F5 SERPINC1
3 methylation GO:0032259 9.86 AHCY BHMT MTR MTRR
4 platelet degranulation GO:0002576 9.79 ALB F5 SERPINE1
5 hemostasis GO:0007599 9.69 F5 SERPINC1 THBD
6 cobalamin metabolic process GO:0009235 9.62 MTR MTRR
7 folic acid metabolic process GO:0046655 9.61 MTHFR MTRR
8 positive regulation of monocyte chemotaxis GO:0090026 9.61 CCL2 SERPINE1
9 nitric oxide mediated signal transduction GO:0007263 9.6 APOE NOS3
10 high-density lipoprotein particle remodeling GO:0034375 9.59 ALB APOE
11 positive regulation of cholesterol efflux GO:0010875 9.58 APOE PON1
12 negative regulation of fibrinolysis GO:0051918 9.58 SERPINE1 THBD
13 S-adenosylmethionine metabolic process GO:0046500 9.55 BHMT MTHFR
14 methionine metabolic process GO:0006555 9.54 MTHFR MTRR
15 homocysteine metabolic process GO:0050667 9.52 CBS MTHFR
16 negative regulation of blood coagulation GO:0030195 9.5 APOE SERPINE1 THBD
17 transsulfuration GO:0019346 9.49 CBS CTH
18 S-adenosylmethionine cycle GO:0033353 9.48 AHCY MTRR
19 cysteine biosynthetic process GO:0019344 9.46 CBS CTH
20 homocysteine catabolic process GO:0043418 9.43 CBS MTRR
21 methionine biosynthetic process GO:0009086 9.43 BHMT MTR MTRR
22 hydrogen sulfide biosynthetic process GO:0070814 9.4 CBS CTH
23 cysteine biosynthetic process via cystathionine GO:0019343 9.37 CBS CTH
24 cellular amino acid biosynthetic process GO:0008652 9.35 CBS CTH FOLH1 MTR MTRR
25 negative regulation of platelet activation GO:0010544 9.33 APOE NOS3 THBD
26 sulfur amino acid metabolic process GO:0000096 8.92 AHCY BHMT MTR MTRR

Molecular functions related to Hyperhomocysteinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 9.5 MTHFR MTRR NOS3
2 FMN binding GO:0010181 9.37 MTRR NOS3
3 modified amino acid binding GO:0072341 9.26 CBS MTHFR
4 NADPH-hemoprotein reductase activity GO:0003958 9.16 MTRR NOS3
5 pyridoxal phosphate binding GO:0030170 9.13 ALB CBS CTH
6 NADP binding GO:0050661 8.8 MTHFR MTRR NOS3

Sources for Hyperhomocysteinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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