MCID: HYP050
MIFTS: 53

Hyperinsulinemic Hypoglycemia malady

Categories: Genetic diseases, Metabolic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Hyperinsulinemic Hypoglycemia

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Aliases & Descriptions for Hyperinsulinemic Hypoglycemia:

Name: Hyperinsulinemic Hypoglycemia 10 12
Nesidioblastosis 10 47 36 65
 
Islet Cell Hyperplasia 10 24
Persistent Hyperinsulinemia Hypoglycemia of Infancy 10

Classifications:



External Ids:

Disease Ontology10 DOID:13317
ICD1027 E16.9
MeSH36 D046768
NCIt42 C4375
UMLS65 C0027773

Summaries for Hyperinsulinemic Hypoglycemia

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Wikipedia:68 Hyperinsulinemic hypoglycemia describes the condition and effects of low blood glucose caused by... more...

MalaCards based summary: Hyperinsulinemic Hypoglycemia, also known as nesidioblastosis, is related to hyperinsulinemic hypoglycemia, familial, 4 and obesity. An important gene associated with Hyperinsulinemic Hypoglycemia is ABCC8 (ATP Binding Cassette Subfamily C Member 8), and among its related pathways are Disorders of transmembrane transporters and Aldosterone-regulated sodium reabsorption. Affiliated tissues include lung, brain and liver, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Disease Ontology:10 A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin.

Related Diseases for Hyperinsulinemic Hypoglycemia

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Diseases in the Hyperinsulinemic Hypoglycemia family:

Hyperinsulinemic Hypoglycemia, Familial, 7 Hyperinsulinemic Hypoglycemia, Familial, 4
Hyperinsulinemic Hypoglycemia, Familial, 3 Hyperinsulinemic Hypoglycemia, Familial, 1
Hyperinsulinemic Hypoglycemia, Familial, 2 Hyperinsulinemic Hypoglycemia, Familial, 5

Diseases related to Hyperinsulinemic Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1hyperinsulinemic hypoglycemia, familial, 433.7GCK, GLUD1, HADH
2obesity26.4ABCC8, GCK, HNF4A, IGF2, INS, INSR
3hyperinsulinemic hypoglycemia, familial, 212.5
4hyperinsulinemic hypoglycemia, familial, 712.4
5hyperinsulinemic hypoglycemia, familial, 312.4
6hyperinsulinemic hypoglycemia, familial, 512.4
7hyperinsulinemic hypoglycemia, familial, 112.4
8adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia12.1
9hyperinsulinism-hyperammonemia syndrome11.7
10slc16a1-related hyperinsulinism11.2
11insr-related hyperinsulinism11.2
12exercise-induced hyperinsulinism11.2
13hyperinsulinism due to insr deficiency11.2
14hypoglycemia11.1
15hyperinsulinism due to glucokinase deficiency11.1
16glud1-related hyperinsulinism11.1
17hyperinsulinism due to hnf4a deficiency11.1
18autosomal dominant hyperinsulinism due to kir6.2 deficiency11.1
19autosomal dominant hyperinsulinism due to sur1 deficiency11.1
20diazoxide-resistant focal hyperinsulinism due to sur1 deficiency11.1
21diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency11.1
22hyperinsulinism due to ucp2 deficiency11.1
23hyperinsulinism due to hnf1a deficiency11.1
24hyperinsulinism due to short chain 3-hydroxylacyl-coa dehydrogenase deficiency11.1
25autosomal recessive hyperinsulinism due to sur1 deficiency11.1
26autosomal recessive hyperinsulinism due to kir6.2 deficiency11.1
27pancreatitis10.5
28maturity-onset diabetes of the young, type 1310.5ABCC8, KCNJ11
29usher syndrome, type 1c10.5ABCC8, KCNJ11
30diabetes mellitus, transient neonatal, 310.5ABCC8, KCNJ11
31sparse hair-short stature-skin anomalies syndrome10.4ABCC8, KCNJ11
32insulinoma10.3
33aphasia10.2ABCC8, GCK, KCNJ11
34conversion disorder10.2ABCC8, GCK, KCNJ11
35maturity-onset diabetes of the young10.2
36microcephaly, short stature, and impaired glucose metabolism10.1
37gastrointestinal stromal tumor10.1
38beckwith-wiedemann syndrome10.1
39costello syndrome10.1
40hyperinsulinism10.1
41neuroblastoma9.9
42west syndrome9.9
43hepatitis9.9
44liver cirrhosis9.9
45morbid obesity9.9
46retinitis pigmentosa9.9
47mumps9.9
48glucose intolerance9.9
49microcephaly9.9
50bartonellosis9.9

Graphical network of the top 20 diseases related to Hyperinsulinemic Hypoglycemia:



Diseases related to hyperinsulinemic hypoglycemia

Symptoms for Hyperinsulinemic Hypoglycemia

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Drugs & Therapeutics for Hyperinsulinemic Hypoglycemia

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Drugs for Hyperinsulinemic Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 103)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Insulin GlargineapprovedPhase 4495160337-95-1
Synonyms:
Insulin Glargine (rDNA origin)
 
Lantus
Lantus Solostar
2
Rosiglitazoneapproved, investigationalPhase 4220122320-73-477999
Synonyms:
(RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion
(±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione
122320-73-4
2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate
5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(methyl-(2-pyridyl)amino)ethoxy]phenyl]methyl] thiazolidine-2,4-dione
5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
AC-3459
AC1L2U9N
Avandia
BRD-A97437073-001-02-3
BRD-A97437073-001-03-1
BRL49653
BSPBio_002693
Brl 49653
Brl-49653
C18H19N3O3S
CID77999
D08491
DB00412
Gaudil
Gaudil (TN)
HMS1922J11
HMS2094O13
HSDB 7555
I06-0141
IDMB (1uM BRL49653, 1uM Dexamethasone, 0.5uM IBMX, 10ug/mL Insulin)
KBio2_002183
KBio2_004751
KBio2_007319
KBio3_001913
KBioGR_001609
 
KBioSS_002183
LS-151340
MolPort-002-508-212
NCGC00095124-01
NCGC00095124-02
NCGC00095124-03
RGZ
RSG
Rosi
Rosigilitazone
Rosigliazone maleate
Rosiglitazon
Rosiglitazona
Rosiglitazone
Rosiglitazone (INN)
Rosiglitazone Maleate
Rosiglitazone [INN:BAN]
Rosiglitazone maleate
Rosiglitazonum
Rosiglizole
S00306
SPBio_001142
SPECTRUM1504263
STOCK6S-23924
Spectrum2_001241
Spectrum3_000997
Spectrum4_001125
Spectrum5_001464
Spectrum_001703
TDZ 01
UNII-05V02F2KDG
[3H]rosiglitazone
rosiglitazona
rosiglitazone
rosiglitazone (Avandia)
rosiglitazonum
3
ZincapprovedPhase 4, Phase 014777440-66-623994, 32051
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
4
MetforminapprovedPhase 41645657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
5
Acarboseapproved, investigationalPhase 4, Phase 28056180-94-0441184
Synonyms:
1,4-DEOXY-4-((5-HYDROXYMETHYL-2,3,4-TRIHYDROXYCYCLOHEX-5,6-ENYL)AMINO)FRUCTOSE
1agm
1gah
1k1y
1lf9
1ukt
56180-94-0
AC1L26GM
AC1L9APL
AC1L9G0J
AC1L9HYX
AC1NAU1X
AC1OCEJZ
ACI-(1-4)GLD-(1-4)GLC-(1-4)GLB
Acarbosa
Acarbosa [INN-Spanish]
Acarbose
Acarbose (JAN/USAN/INN)
Acarbose [USAN:BAN:INN:JAN]
Acarbosum
Acarbosum [INN-Latin]
Alpha-Acarbose
BAY-g 5421
BB_NC-1311
Bay g 5421
Bay-g-5421
Beta-Acarbose
C06802
C25H43NO18
CHEBI:2376
CHEBI:506767
CHEMBL1566
CHEMBL394434
 
CHEMBL569486
CID10627975
CID41774
CID441184
CID4432690
CID444254
CID445421
CPD000466376
D00216
DB00284
EINECS 260-030-7
Glucobay
Glucor
HMC-(1-4)AGL-(1-4)GLC-(1-4)GLC
HMS2051F03
HMS2093I22
LS-71702
MLS000759506
MLS001424056
MolPort-002-507-369
MolPort-003-844-373
NCGC00096061-01
NCGC00096061-02
NCGC00160515-01
Prandase
Prandase, Precose, Glucobay, Bay-g 5421, Acarbose
Precose
Precose (TN)
S1271_Selleck
SAM001246733
SMR000466376
SPECTRUM1505172
STK801930
UNII-T58MSI464G
acarbose
6
VerapamilapprovedPhase 411752-53-92520
Synonyms:
(+-)-Verapamil
(+/-)-VERAPAMIL
(1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile
2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
52-53-9
56949-77-0
AB00053495
AC-16016
AC1L1DV5
Akilen
Anpec
Apo-Verap
Arpamyl
Arpamyl LP
BPBio1_000268
BRD-A09533288-001-02-7
BRD-A09533288-003-05-6
BSPBio_000242
BSPBio_001513
BSPBio_002358
Berkatens
Bio-0754
Bio1_000425
Bio1_000914
Bio1_001403
Bio2_000233
Bio2_000713
C07188
C27H38N2O4
CCRIS 6749
CHEBI:9948
CHEMBL6966
CID2520
CP-16533-1
CP-165331
Calan
Calan SR
Calan Sr
Calan sr
Calaptin
Calaptin 240 SR
Calcan
Cardiabeltin
Cardiagutt
Cardibeltin
Cardioprotect
Caveril
Civicor
Civicor Retard
Coraver
Cordilox
Cordilox SR
Corpamil
Covera-HS
Covera-Hs
Covera-hs
D-365
D02356
DB00661
Dexverapamil
Dignover
Dilacoran
Dilacoran HTA
DivK1c_000399
Drosteakard
Durasoptin
EINECS 200-145-1
EINECS 260-462-6
Elthon
FT-0080127
Falicard
Finoptin
Flamon
Geangin
HMS1791L15
HMS1989L15
HMS2089H17
Harteze
Hexasoptin
Hexasoptin Retard
Hormitol
I06-0063
IDI1_000399
IDI1_033983
Ikacor
Ikapress
Inselon
Iproveratril
Isoptimo
Isoptin
Isoptin Retard
Isoptin SR
Isoptin sr
Isoptine
Isoptino
Isotopin
Izoptin
Jenapamil
KBio1_000399
KBio2_000233
KBio2_002343
KBio2_002801
KBio2_004911
KBio2_005369
KBio2_007479
KBio3_000465
KBio3_000466
KBio3_002823
KBioGR_000233
 
KBioGR_001372
KBioGR_002343
KBioSS_000233
KBioSS_002346
L001330
LS-174
Lekoptin
Lodixal
Lopac0_001237
Magotiron
Manidon
Manidon Retard
MolPort-000-721-258
NCGC00016083-14
NCGC00024710-04
NCGC00024710-05
NCGC00024710-06
NCGC00024710-07
NCGC00024710-08
NCGC00024710-09
NCI60_020143
NINDS_000399
NSC272366
NU-Verap
Novapamyl LP
Novo-Veramil
Nu-Verap
Ormil
Praecicor
Prestwick0_000141
Prestwick1_000141
Prestwick2_000141
Prestwick3_000141
Quasar
Rapam
Robatelan
SID104171262
SID124881789
SID124881790
SPBio_001820
SPBio_002181
STK538085
Securon
Spectrum2_001740
Spectrum4_000906
Spectrum5_001786
Tarka
UNII-CJ0O37KU29
Univer
Univex
VERAPAMIL
Vasolan
Vasomil
Vasopten
Vera-Sanorania
Verabeta
Veracaps SR
Veracim
Veracor
Verahexal
Veraloc
Veramex
Veramil
Verapamil
Verapamil (USAN/INN)
Verapamil AL
Verapamil Acis
Verapamil Atid
Verapamil Basics
Verapamil Ebewe
Verapamil HCl
Verapamil Henning
Verapamil Hydrochloride
Verapamil Injection
Verapamil MSD
Verapamil NM
Verapamil NM Pharma
Verapamil Nordic
Verapamil PB
Verapamil Riker
Verapamil SR
Verapamil Verla
Verapamil [USAN:BAN:INN]
Verapamil [USAN:INN:BAN]
Verapamil [Usan:Ban:Inn]
Verapamil-AbZ
Verapamilo
Verapamilo [INN-Spanish]
Verapamilum
Verapamilum [INN-Latin]
Verapin
Verapress 240 SR
Veraptin
Verasal
Verasifar
Veratensin
Verdilac
Verelan
Verelan PM
Verelan Pm
Verelan SR
Verexamil
Veroptinstada
Verpamil
Vetrimil
Vortac
Vérapamil
alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
cMAP_000023
delta-365
nchembio.368-comp2
nchembio.79-comp5
7
LiraglutideapprovedPhase 4278204656-20-2
Synonyms:
204656-20-2
Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
C439759
Liraglutida
Liraglutida [INN-Spanish]
Liraglutide
Liraglutide [USAN:INN]
Liraglutidum
Liraglutidum [INN-Latin]
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)GLP-1-(7-37)-peptide
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide
 
NN 2211
NN-2211
NN2211
NNC 90-1170
N²⁶-(N-Hexadecanoyl-L-gamma-glutamyl)-[34-L-arginine]glucagon-like peptide 1-(7-37)-peptide
N²⁶-(hexadecanoyl-gamma-glutamyle)-[34-arginine]GLP-1-(7-37)-peptide
Saxenda
UNII-839I73S42A
Victoza
nn 2211
nn2211
victoza
8IncretinsPhase 4, Phase 3, Phase 2, Phase 01326
9Anti-Arrhythmia AgentsPhase 4, Phase 02371
10Insulin, Globin ZincPhase 4, Phase 3, Phase 2, Phase 1, Phase 04278
11Protease InhibitorsPhase 4, Phase 34558
12Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 2, Phase 09988
13HIV Protease InhibitorsPhase 4, Phase 34558
14insulinPhase 4, Phase 3, Phase 2, Phase 1, Phase 04278
15Dipeptidyl-Peptidase IV InhibitorsPhase 4, Phase 3779
16Hypoglycemic AgentsPhase 4, Phase 3, Phase 2, Phase 1, Phase 04503
17Hormone AntagonistsPhase 4, Phase 3, Phase 2, Phase 010002
18HormonesPhase 4, Phase 3, Phase 2, Phase 011748
19Sitagliptin PhosphatePhase 4399
20Glucagon-Like Peptide 1Phase 4, Phase 2, Phase 3, Phase 1, Phase 0620
21glucagonPhase 4, Phase 2, Phase 3, Phase 0379
22gastric inhibitory polypeptidePhase 479
23Glycoside Hydrolase InhibitorsPhase 4, Phase 2111
24Vasodilator AgentsPhase 4, Phase 2, Phase 32926
25Calcium, DietaryPhase 44678
26calcium channel blockersPhase 41743
27Cardiac GlycosidesPhase 4, Phase 2128
28
SaxagliptinapprovedPhase 3120361442-04-811243969
Synonyms:
(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile
(1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)- (9CI)
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
361442-04-8
AC-6008
BMS 477118
BMS 477118-11
BMS-477118
 
BMS-477118-11
CHEBI:460723
CHEMBL385517
CID11243969
DB06335
OPC-262
Onglyza
S1540_Selleck
Saxagliptin
Saxagliptin Hydrochloride
29
Exenatideapproved, investigationalPhase 2, Phase 3, Phase 0269141758-74-915991534
Synonyms:
141732-76-5
141758-74-9
286014-72-0
335149-21-8
AC 2993
AC 2993 LAR
AC 2993A
AC-2993
AC002993
AC2993
AC2993a
Bydureon
Byetta
 
C074031
CHEBI:490990
CHEMBL414357
Ex4 peptide
Exenatide
Exenatide Synthetic
Exenatide synthetic
Exendin 4
Exendin 4 (Heloderma suspectum)
Exendin-4
Extendin-4
LY2148568
Synthetic exendin-4
UNII-9P1872D4OL
30
DiazoxideapprovedPhase 2, Phase 321364-98-73019
Synonyms:
2H-1,2, 4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
364-98-7
7-Chloro-3-methyl-1lambda~4~,2,4-benzothiadiazin-1-ol 1-oxide
7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido
7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido [Italian]
7-chloro-3-methyl-4H-1
AC1L1EZN
Aroglycem
BPBio1_000016
BRD-K73109821-001-05-2
BSPBio_000014
BSPBio_001307
BSPBio_002290
Bio1_000036
Bio1_000525
Bio1_001014
Bio2_000027
Bio2_000507
C06949
C8H7ClN2O2S
CAS-364-98-7
CBiol_001750
CHEBI:4495
CHEMBL181
CID3019
CPD000058392
D 9035
D00294
D003981
D9035_SIGMA
DB01119
Diazossido
Diazossido [DCIT]
Diazossido [Italian]
Diazoxide
Diazoxide (JAN/USP/INN)
Diazoxide [USAN:INN:BAN]
Diazoxido
Diazoxido [INN-Spanish]
Diazoxidum
Diazoxidum [INN-Latin]
Dizoxide
EINECS 206-668-1
EU-0100404
Eudemine
HMS1361B09
HMS1568A16
HMS1791B09
HMS1922L22
HMS1989B09
HMS2051P20
HMS2089L04
HMS2093N12
Hyperstat
Hyperstat (TN)
Hypertonalum
I06-2041
 
IDI1_033777
KBio2_000027
KBio2_002595
KBio2_005163
KBio3_000053
KBio3_000054
KBio3_001510
KBioGR_000027
KBioGR_001776
KBioSS_000027
LS-40410
Lopac-D-9035
Lopac0_000404
MLS000028459
MLS001076071
MolPort-003-666-772
MolPort-003-941-186
Mutabase
NCGC00015380-01
NCGC00015380-02
NCGC00015380-03
NCGC00015380-05
NCGC00015380-12
NCGC00024907-01
NCGC00024907-02
NCGC00024907-03
NCGC00024907-04
NCGC00024907-05
NCGC00024907-06
NCGC00024907-07
NCGC00024907-08
NSC 64198
NSC 76130
NSC-64198
NSC64198
NSC76130
Prestwick0_000087
Prestwick1_000087
Prestwick2_000087
Prestwick3_000087
Prestwick_163
Proglicem
Proglycem
SAM001246872
SMR000058392
SPBio_001953
SPECTRUM2300206
SRG 95213
SRG-95213
Sch 6783
Sch-6783
Spectrum3_000735
Spectrum4_001248
Tocris-0964
UNII-O5CB12L4FN
VU0239714-6
ZINC03872277
diazoxide
nchembio.150-comp49
nchembio.476-comp10
31Antihypertensive AgentsPhase 2, Phase 33618
32
Octreotideapproved, investigationalPhase 219883150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
 
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Ocphyl
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide acetate
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatin
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
33
AcetylcysteineapprovedPhase 1, Phase 2293616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
34
PancrelipaseapprovedPhase 288053608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
35
SomatostatinPhase 215351110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
36Anti-Infective AgentsPhase 1, Phase 217220
37Protective AgentsPhase 1, Phase 25651
38Gastrointestinal AgentsPhase 26401
39Respiratory System AgentsPhase 1, Phase 2, Phase 03931
40Antiviral AgentsPhase 1, Phase 28071
41AntioxidantsPhase 1, Phase 22442
42ExpectorantsPhase 1, Phase 2337
43N-monoacetylcystinePhase 1, Phase 2293
44pancreatinPhase 2880
45DihydroxyphenylalaninePhase 2123
46cysteineNutraceuticalPhase 1, Phase 2, Phase 0150
47CinnamonNutraceuticalPhase 132
48
Glyburideapproved10710238-21-83488
Synonyms:
1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
10238-21-8
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
AB00051949
AC1L1G1Q
AC1Q44V7
AKOS001487495
Abbenclamide
Adiab
Apo-Glibenclamide
Azuglucon
BIDD:GT0239
BPBio1_000344
BRD-K36927236-001-06-0
BRN 2230085
BSPBio_000312
BSPBio_001351
BSPBio_003053
Bastiverit
Benclamin
Betanase
Betanese 5
Bio-0156
Bio1_000076
Bio1_000565
Bio1_001054
Bio2_000071
Bio2_000551
C07022
C23H28ClN3O5S
CAS-10238-21-8
CBiol_001790
CHEBI:5441
CHEMBL472
CID3488
CPD000058229
Calabren
Cytagon
D00336
D005905
DB01016
Daonil
Debtan
Dia-basan
Diabeta
Diabeta (TN)
Diabiphage
Dibelet
DivK1c_000481
Duraglucon
EINECS 233-570-6
EU-0100499
Euclamin
Euglucan
Euglucon
Euglucon 5
Euglucon N
Euglykon
G 0639
G0639_SIAL
G0639_SIGMA
G2539_SIAL
GBN 5
Gen-Glybe
Gewaglucon
Gilemal
Glamide
Glibadone
Gliban
Gliben
Gliben-Puren N
Glibenbeta
Glibenclamid AL
Glibenclamid Basics
Glibenclamid Fabra
Glibenclamid Genericon
Glibenclamid Heumann
Glibenclamid Riker M
Glibenclamid Riker M.
Glibenclamid-Cophar
Glibenclamid-Ratiopharm
Glibenclamida
Glibenclamida [INN-Spanish]
Glibenclamide
Glibenclamide (JP15/INN)
Glibenclamidum
Glibenclamidum [INN-Latin]
Glibenil
Glibens
Glibesyn
Glibet
Glibetic
Glibil
Gliboral
Glicem
Glidiabet
Glimel
Glimide
Glimidstata
Glisulin
Glitisol
Glubate
Gluben
Gluco-Tablimen
Glucobene
Glucohexal
Glucolon
Glucomid
Glucoremed
Glucoven
Glyben
Glybenclamide
Glybenzcyclamide
Glyburide
Glyburide (USP)
Glyburide (micronized)
Glyburide [USAN]
 
Glycolande
Glycomin
Glynase
Glynase (TN)
HB 419
HB 420
HB-419
HB-420
HB419
HB420
HMS1361D13
HMS1568P14
HMS1791D13
HMS1922L08
HMS1989D13
HMS2089L06
HMS2093P04
HMS501I03
Hemi-Daonil
Hexaglucon
Humedia
I06-0716
IDI1_000481
IDI1_033821
KBio1_000481
KBio2_000071
KBio2_000730
KBio2_002639
KBio2_003298
KBio2_005207
KBio2_005866
KBio3_000141
KBio3_000142
KBio3_002273
KBioGR_000071
KBioGR_001897
KBioSS_000071
KBioSS_000730
LS-159295
Lederglib
Libanil
Lisaglucon
Lopac-G-0639
Lopac0_000499
MLS000069721
MLS001077262
Malix
Maninil
Med-Glionil
Melix
Micronase
Micronase (TN)
Micronized glyburide
Miglucan
MolPort-000-784-850
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N -cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
NCGC00015467-01
NCGC00015467-02
NCGC00015467-06
NCGC00015467-16
NCGC00016689-01
NCGC00023447-02
NCGC00023447-04
NCGC00023447-05
NCGC00023447-06
NCGC00023447-07
NCGC00023447-08
NCGC00023447-09
NCGC00023447-10
NCGC00023447-11
NCGC00023447-12
NINDS_000481
Nadib
Neogluconin
Norglicem 5
Normoglucon
Novo-Glyburide
Oprea1_764617
Orabetic
Pira
Praeciglucon
PresTab
Prestwick0_000316
Prestwick1_000316
Prestwick2_000316
Prestwick3_000316
Prestwick_569
Probes1_000431
Probes2_000378
Prodiabet
Renabetic
S1716_Selleck
SAM002564212
SMR000058229
SPBio_001831
SPBio_002531
SPECTRUM2300229
SR-01000000196-5
STK362992
Semi-Daonil
Semi-Euglucon
Semi-Gliben-Puren N
Semi-daonil
Spectrum2_001816
Spectrum3_001327
Spectrum4_001199
Spectrum5_001631
Spectrum_000250
Sugril
Suraben
Tiabet
Tocris-0911
U 26452
U-26452
UNII-SX6K58TVWC
UPCMLD-DP006
UPCMLD-DP006:001
UR 606
Yuglucon
ZINC00537805
glibenclamide
glyburide
49
Norepinephrineapproved59551-41-2439260
Synonyms:
(-)-(R)-Norepinephrine
(-)-Arterenol
(-)-Arterenol free base
(-)-NORADRENALINE
(-)-Noradrenaline
(-)-Norepinephrine
(-)-alpha-(Aminomethyl)protocatechuyl alcohol
(R)-(-)-Norepinephrine
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
(R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol
(R)-Noradrenaline
(R)-Norepinephrine
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI)
4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
4899-05-2
51-40-1 (l-tartrate (1:1))
51-41-2
66197-73-7
A7257_SIGMA
AC1L96ZT
ALBB-006229
Adrenor
Aktamin
Arterenol
BRN 4231961
BSPBio_002079
C00547
CHEBI:18357
CHEMBL1437
CID439260
D-(-)-Noradrenaline
D00076
D53D5E3A-2360-4CA9-8031-6C2CD4062FD5
DB00368
DivK1c_000230
EINECS 200-096-6
HMS1920B08
HMS2089E18
HMS2091J08
HMS500L12
IDI1_000230
KBio1_000230
KBio2_001489
KBio2_004057
KBio2_006625
KBio3_001579
KBioGR_000635
KBioSS_001489
L-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
L-3,4-Dihydroxyphenylethanolamine
L-3,4-dihydroxyphenylethanolamine
L-Arterenol
L-Noradrenaline
L-Norepinephrine
L-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol
L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol
L-arterenol
L-noradrenaline
LS-42676
 
LT03330026
LT4
Levarterenol
Levarterenolo
Levarterenolo [DCIT]
Levoarterenol
Levonor
Levonoradrenaline
Levonorepinephrine
Levophed
NCGC00159406-02
NCGC00159406-03
NCGC00159406-04
NCGC00159406-05
NCGC00159406-06
NCGC00159406-07
NCGC00159406-09
NINDS_000230
Nor adrenalin
Nor adrenalin (TN)
Nor-Epirenan
Noradrenalin
Noradrenalina
Noradrenalina [Italian]
Noradrenaline
Noradrenaline (JP15)
Noradrenalinum
Norartrinal
Noreinefrina
Noreinefrina [INN-Spanish]
Norepinefrina
Norepinephrine
Norepinephrine (INN)
Norepinephrine Noradrenalin
Norepinephrine [INN:JAN]
Norepinephrine l-Tartrate (1:1)
Norepinephrinum
Norepinephrinum [INN-Latin]
Norepirenamine
PDSP1_001111
PDSP2_001095
SGCUT00123
SPBio_001048
SPECTRUM1500436
STK503776
Spectrum2_001064
Spectrum3_000520
Spectrum4_000078
Spectrum5_001068
Spectrum_001009
Sympathin E
UNII-X4W3ENH1CV
bmse000404
l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol
l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
nchembio.284-comp2
nchembio.64-comp2
nchembio705-1
noradrenaline
norepinefrina
norepinephrine
norepinephrinum
to_000024
50
Alprazolamapproved, illicit, investigational6528981-97-72118
Synonyms:
28981-97-7
611026_ALDRICH
611026_FLUKA
8-Chloro-1-methyl-6-(phenyl-d5)-4H-(1,2,4)triazolo[4,3-a][1,4]benzodiazepine
8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine
8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-alpha)(1,4)benzodiazepine
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
A6551_FLUKA
A6551_SIGMA
A8800_SIGMA
AC-18721
AC1L1CYL
AKOS005066050
AP-1002
AZ-002
Alcelam
Algad
Alpaz
Alphapharm Brand of Alprazolam
Alplax
Alpram
Alprax
Alprazolam
Alprazolam (JP15/USP/INN)
Alprazolam Alphapharm Brand
Alprazolam Apotex Brand
Alprazolam ER
Alprazolam EXTENDED-RELEASE
Alprazolam Extended Release
Alprazolam Extended-release
Alprazolam Kenral Brand
Alprazolam Novopharm Brand
Alprazolam Nu-Pharm Brand
Alprazolam Orion Brand
Alprazolam Pfizer Brand
Alprazolam Temmler Brand
Alprazolam XR
Alprazolam [USAN:INN:BAN:JAN]
Alprazolam extended release
Alprazolam extended release tablets
Alprazolam intensol
Alprazolam solution
Alprazolam-d5
Alprazolamum
Alprazolamum [INN-Latin]
Alprazolan
Alpronax
Alprox
Alviz
Alzam
Alzolam
Alzon
Anpress
Apo Alpraz
Apo-Alpraz
ApoAlpraz
Apotex Brand of Alprazolam
Arzneimittelwerk Dresden Brand of Alprazolam
Azor
BIDD:GT0475
BIDD:PXR0150
BRN 1223125
Bestrol
Bio-0790
C06817
CHEBI:2611
CHEMBL661
CID2118
CPD000149316
Cassadan
Constan
D 65MT
D-65MT
D000525
D00225
D65MT
DB00404
DEA No. 2882
EINECS 249-349-2
Esparon
 
Frontal
Gen-Alprazolan
HMS2051A10
HSDB 7207
Helex
I14-7472
Intensol
Kenral Brand of Alprazolam
Ksalol
LS-156344
MLS000559000
MLS000759485
Mialin
MolPort-002-507-836
NCGC00159466-02
NCGC00159466-03
Neurol
Niravam
Novo Alprazol
Novo-Alprazol
NovoAlprazol
Novopharm Brand of Alprazolam
Nu Alpraz
Nu Pharm Brand of Alprazolam
Nu-Alpraz
Nu-Pharm Brand of Alprazolam
NuAlpraz
Orion Brand of Alprazolam
Panistat
Panix
Pfizer Brand of Alprazolam
Pharnax
Prazam
Prazolan
Prinox
Ralozam
Relaxol
Restyl
SAM001246696
SMR000149316
STK590494
Solanax
Staccato-alprazolam
TGAR01P
TUS-1
Tafil
Tafil D
Temmler Brand of Alprazolam
Tensivan
Tranax
Trankimazin
Tranquinal
Tricalma
Tus 1
U 31889
U-31,889
U-31889
U31,889
UNII-YU55MQ3IZY
Unilan
Valeans
Xanagis
Xanax
Xanax (TN)
Xanax TS
Xanax XR
Xanolam
Xanor
ZINC00000903
Zacetin
Zanapam
Zaxan
Zenax
Zolam
Zolan
Zolarem
Zoldac
Zoldax
Zopax
Zopic
Zotran
alprazolam
nchembio747-comp35

Interventional clinical trials:

(show all 45)
idNameStatusNCT IDPhase
1Prevention of Severe Hypoglycemia in Type 1 DiabetesCompletedNCT00360984Phase 4
2Rosiglitazone and Insulin in T1DM AdolescentsCompletedNCT00372086Phase 4
3Sitagliptin and Glucagon CounterregulationRecruitingNCT02256189Phase 4
4Treatment of Hypoglycemia Following Gastric Bypass SurgeryEnrolling by invitationNCT02527993Phase 4
5DPP4inhibitors in Type 1 DiabetesCompletedNCT01922817Phase 3
6New Imaging Procedure for the Localisation of Insulinoma and Transplanted Islet CellsRecruitingNCT02127541Phase 2, Phase 3
7Diazoxide In the Management Of Hypoglycemic NeonatesNot yet recruitingNCT00994149Phase 2, Phase 3
8Exenatide and Impaired Hypoglycaemic Awareness in Type 1 DiabetesNot yet recruitingNCT02735031Phase 2, Phase 3
9Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping SyndromeCompletedNCT01895296Phase 2
10Efficacy, Tolerability and Pharmacokinetics of Subcutaneous Exendin (9-39) in Patients With Post Bariatric HypoglycemiaRecruitingNCT02771574Phase 2
11A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 DiabetesRecruitingNCT02206152Phase 1, Phase 2
12Utility of [F-18] fluoroDOPA for Neonatal HyperinsulinismActive, not recruitingNCT00674440Phase 2
13Phase II Safety and Efficacy Study of F-DOPA PET/CT in Children With Hyperinsulinemic HypoglycemiaActive, not recruitingNCT01468454Phase 2
14A Pilot Study Evaluating Exenatide for the Treatment of Postprandial Hyperinsulinemic Hypoglycemia Post-RYGBNot yet recruitingNCT02685852Phase 2
15Efficacy of Small Subcutaneous Glucagon Dose to Treat Hypoglycemia in Adults With Type 1 DiabetesWithdrawnNCT01828125Phase 2
16Role of GLP-1 in Hyperinsulinemic Hypoglycemia Post-bariatric SurgeryRecruitingNCT02550145Phase 1
17Effect of Cinnamon Extract on Insulin Resistance in Polycystic Ovary SyndromeTerminatedNCT00970541Phase 1
18Post-Gastric Bypass HypoglycemiaCompletedNCT01933490
19Sympathetic Nerve Activity During Hypoglycemia and ExerciseCompletedNCT00608348
20The Effects of Hypoglycaemia in People With Type 2 DiabetesCompletedNCT02205996
21Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q.3CompletedNCT00742521
22Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4CompletedNCT00574340
23Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q2CompletedNCT00592332
24Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes MellitusCompletedNCT00943787
25Evaluation of the Effect of Hypoglycemia With PET and a Norepinephrine Transporter LigandCompletedNCT02056249
26Metabolic Adaptations to Diabetes in African AmericansCompletedNCT00780195
27Glimepiride Induced Insulin Secretion Will be Inhibited by HypoglycemiaCompletedNCT00608179
28Metabolic Adaptation to DiabetesCompletedNCT00732862
29Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 DiabeticsCompletedNCT00481598
3068Ga-NOTA-exendin-4 PET/CT for the Localization of Insulinoma and Diagnosis of NesidioblastosisRecruitingNCT02560376Phase 0
31Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes MellitusRecruitingNCT00607646
32Etiology, Assessment and Treatment of Post-gastric Bypass Severe HypoglycemiaRecruitingNCT01865760
33Hypoglycemia and Autonomic Nervous System FunctionRecruitingNCT01816893
34Brain Ketone Metabolism in Type 1 DiabetesRecruitingNCT02471040
35Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass SurgeryActive, not recruitingNCT00992901Phase 0
36Mechanisms of Hypoglycemia Associated Autonomic Dysfunction Question 2Active, not recruitingNCT00574639
37Study of the Use of [18F]-DOPA in Hyperinsulinemic HypoglycemiaAvailableNCT02533219
3818F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic HypoglycemiaAvailableNCT01916148
39Dose Response of EpinephrineNot yet recruitingNCT02692313
40Adverse Effects of Systemic Hypoglycemia Exposure on Endothelial Function in HumansTerminatedNCT01660009
41Tight Glycaemic Control During Cardiac SurgeryTerminatedNCT01225159
42The Effects of Antecedent Hypoglycemia or Exercise on the Response of the Brain to Subsequent HypoglycemiaWithdrawnNCT00600730
43Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q5WithdrawnNCT00605774
44Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4WithdrawnNCT00608816
45Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes MellitusWithdrawnNCT00608101

Search NIH Clinical Center for Hyperinsulinemic Hypoglycemia


Cochrane evidence based reviews: nesidioblastosis

Genetic Tests for Hyperinsulinemic Hypoglycemia

About this section

Anatomical Context for Hyperinsulinemic Hypoglycemia

About this section

MalaCards organs/tissues related to Hyperinsulinemic Hypoglycemia:

33
Lung, Brain, Liver, Endothelial, Breast, Thyroid, Ovary

Animal Models for Hyperinsulinemic Hypoglycemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Hyperinsulinemic Hypoglycemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.0ABCC8, IGF2, INS, KCNJ11, SST
2MP:00053708.0GCK, HNF4A, IGF2, INS, INSR
3MP:00053677.9GCK, HADH, IGF2, INS, INSR
4MP:00053797.1ABCC8, GCK, GLUD1, HADH, IGF2, INS
5MP:00053786.1GCK, GLUD1, HADH, HNF4A, IGF2, INS
6MP:00053765.5ABCC8, GCK, GLUD1, HADH, HNF4A, IGF2

Publications for Hyperinsulinemic Hypoglycemia

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Articles related to Hyperinsulinemic Hypoglycemia:

(show top 50)    (show all 255)
idTitleAuthorsYear
1
Post-Gastric Bypass Hyperinsulinemic Hypoglycemia: Fructose is a Carbohydrate Which Can Be Safely Consumed. (26037514)
2015
2
Persistent hyperinsulinemic hypoglycemia of infancy: a clinical and pathological study of 19 cases in a single institution. (26823758)
2015
3
Clinical and molecular data from 61 Brazilian cases of Congenital Hyperinsulinemic Hypoglycemia. (25972930)
2015
4
Recognition and management of hyperinsulinemic hypoglycemia after bariatric surgery. (26522879)
2015
5
Biomarkers of Insulin for the Diagnosis of Hyperinsulinemic Hypoglycemia in Infants and Children. (26490124)
2015
6
Hyperinsulinemic hypoglycemia syndrome associated with mutations in the human insulin receptor gene: Report of two cases. (25753915)
2015
7
Hyperinsulinemic Hypoglycemia in Infancy: Current Concepts in Diagnosis and Management. (26713990)
2015
8
Sirolimus in severe hyperinsulinemic hypoglycemia. (24941188)
2014
9
Poor pregnancy outcome after octreotide treatment during pregnancy for familial hyperinsulinemic hypoglycemia: a case report. (25404386)
2014
10
Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: A potential new approach for the treatment of hyperinsulinemic hypoglycemia. (24423625)
2014
11
Treatment of hyperinsulinemic hypoglycemia because of diffuse nesidioblastosis with nifedipine after surgical therapies in a newborn. (23751383)
2013
12
Heterogeneity in phenotype of usher-congenital hyperinsulinism syndrome: hearing loss, retinitis pigmentosa, and hyperinsulinemic hypoglycemia ranging from severe to mild with conversion to diabetes. (23150283)
2013
13
Monogenic hyperinsulinemic hypoglycemia: current insights into the pathogenesis and management. (23384201)
2013
14
Limited value of 18F-F-DOPA PET to localize pancreatic insulin-secreting tumors in adults with hyperinsulinemic hypoglycemia. (19915018)
2010
15
Severe dietary protein sensitivity and hyperinsulinemic hypoglycemia in a patient with heterozygous mutation in HADH gene. (21175096)
2010
16
Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications. (20830240)
2010
17
Diffuse nesidioblastosis causing hyperinsulinemic hypoglycemia: the importance of pancreatic sampling on EUS. (18547573)
2008
18
Diffuse nesidioblastosis as a cause of hyperinsulinemic hypoglycemia in adults: a diagnostic and therapeutic challenge. (17263973)
2007
19
Costello syndrome and hyperinsulinemic hypoglycemia. (16278907)
2005
20
Persistent hyperinsulinemic hypoglycemia of infancy (PHHI): Long-term outcome following 95% pancreatectomy. (16459471)
2005
21
Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. (16299937)
2005
22
Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes. (15767809)
2005
23
Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. (16034010)
2005
24
A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. (15161766)
2004
25
Identification of a novel polymorphism in the fibronectin type II domain of the SEL1L gene and possible relation to the persistent hyperinsulinemic hypoglycemia of infancy. (15450414)
2004
26
Megestrol acetate promotes euglycemia and appetite in a child with persistent hyperinsulinemic hypoglycemia of infancy. (15124853)
2004
27
The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma. (12606521)
2003
28
Laparoscopic identification and removal of focal lesions in persistent hyperinsulinemic hypoglycemia of infancy. (14689291)
2003
29
The association of leukocyte adhesion defect type I and persistent hyperinsulinemic hypoglycemia of infancy in a Saudi Arabian family. (12186366)
2002
30
Persistent hyperinsulinemic hypoglycemia of infancy--successful therapy with nifedipine. (12003307)
2002
31
Histologic findings in persistent hyperinsulinemic hypoglycemia of infancy: Australian experience. (11000331)
2000
32
Persistent hyperinsulinemic hypoglycemia with pyloric stenosis. (10951639)
2000
33
Normal growth after administration of octreotide: report on a case of persistent hyperinsulinemic hypoglycemia of infancy treated by continuous subcutaneous injection of octreotide. (12054118)
1999
34
Successful therapy with calcium channel blocker (nifedipine) in persistent neonatal hyperinsulinemic hypoglycemia of infancy. (10614546)
1999
35
Focal and Diffuse Beta Cell Changes in Persistent Hyperinsulinemic Hypoglycemia of Infancy. (12114766)
1999
36
Pancreatic B-cell proliferation in persistent hyperinsulinemic hypoglycemia of infancy: an immunohistochemical study of 18 cases. (9619597)
1998
37
Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy. (9648840)
1998
38
Persistent hyperinsulinemic hypoglycemia in the newborn and infants]. (9885743)
1998
39
Long-term diazoxide treatment in persistent hyperinsulinemic hypoglycemia of infancy: a patient report. (9364348)
1997
40
Mumps infection complicated by transient hyperinsulinemic hypoglycemia. (9109149)
1997
41
Discordance for hyperinsulinemic hypoglycemia in monozygotic twins. (7776078)
1995
42
Persistent hyperinsulinemic hypoglycemia due to nesidiodysplasia in a neonate. (7912588)
1994
43
Persistent hyperinsulinemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy. (8410523)
1993
44
Persistent hyperinsulinemic hypoglycemia of infancy ("nesidioblastosis"): autosomal recessive inheritance in 7 pedigrees. (2260597)
1990
45
Diffuse and focal nesidioblastosis. A clinicopathological study of 24 patients with persistent neonatal hyperinsulinemic hypoglycemia. (2669541)
1989
46
Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide. (3818333)
1986
47
Ketonuria does not exclude hyperinsulinemic hypoglycemia. (6364785)
1984
48
Hyperinsulinemic hypoglycemia of the neonate associated with persistent fetal histology and function of the pancreas. (6244795)
1980
49
Hyperinsulinemic hypoglycemia associated with a neurofibrosarcoma. (1130933)
1975
50

Variations for Hyperinsulinemic Hypoglycemia

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Expression for genes affiliated with Hyperinsulinemic Hypoglycemia

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Search GEO for disease gene expression data for Hyperinsulinemic Hypoglycemia.

Pathways for genes affiliated with Hyperinsulinemic Hypoglycemia

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Pathways related to Hyperinsulinemic Hypoglycemia according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5ABCC8, GCK, KCNJ11
29.4INS, INSR
39.4INS, INSR
49.4INS, INSR
59.4INS, INSR
69.4INS, INSR
7
Show member pathways
9.2ABCC8, INS, KCNJ11
8
Show member pathways
9.0GCK, HNF4A, INS
9
Show member pathways
8.9HNF4A, INS, INSR
10
Show member pathways
8.9ABCC8, GCK, INS, KCNJ11
11
Show member pathways
8.5GCK, HNF4A, INS, INSR
128.0ABCC8, GCK, HADH, HNF4A, INS, KCNJ11
13
Show member pathways
7.9ABCC8, GCK, HNF4A, INS, INSR, KCNJ11

GO Terms for genes affiliated with Hyperinsulinemic Hypoglycemia

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Biological processes related to Hyperinsulinemic Hypoglycemia according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of insulin secretionGO:004667610.3ABCC8, HADH
2response to insulinGO:003286810.2HADH, INSR
3negative regulation of gluconeogenesisGO:004572110.1GCK, INS
4response to glucoseGO:000974910.0GCK, HNF4A
5glucose transportGO:00157589.9GCK, INS
6activation of protein kinase B activityGO:00321489.9INS, INSR
7endocrine pancreas developmentGO:00310189.8HNF4A, INS
8positive regulation of MAPK cascadeGO:00434109.8INS, INSR
9response to nutrient levelsGO:00316679.7IGF2, INSR
10positive regulation of glycolytic processGO:00458219.7GCK, INS, INSR
11response to activityGO:00148239.7HADH, INSR
12wound healingGO:00420609.5IGF2, INS
13glucose homeostasisGO:00425939.5GCK, HNF4A, INSR
14positive regulation of glycogen biosynthetic processGO:00457259.3GCK, IGF2, INS
15regulation of insulin secretionGO:00507969.0ABCC8, GCK, HNF4A, INS
16response to estradiolGO:00323558.8IGF2, INSR, KCNJ11
17glucose metabolic processGO:00060068.4IGF2, INS, KCNJ11
18regulation of transcription, DNA-templatedGO:00063558.2HNF4A, IGF2, INS, INSR
19response to drugGO:00424938.0ABCC8, HADH, HNF4A, IGF2, SST

Molecular functions related to Hyperinsulinemic Hypoglycemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-activated inward rectifier potassium channel activityGO:00152729.9ABCC8, KCNJ11

Sources for Hyperinsulinemic Hypoglycemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet