Hyperinsulinemic Hypoglycemia Familial 2 malady

MalaCards: Hyperinsulinemic Hypoglycemia Familial 2, also known as hyperinsulinemic hypoglycemia, familial, 2, is related to hypoglycemia and hypoglycemia of infancy. An important gene associated with Hyperinsulinemic Hypoglycemia Familial 2 is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11). The drugs glucose and glucagon have been mentioned in the context of this disorder.

OMIM: 601820

hyperinsulinemic hypoglycemia familial 2 30 hyperinsulinemic hypoglycemia, familial, 2 33

hypoglycemia 43 hhf2 30

Disease types for hyperinsulinemic hypoglycemia familial 2 family:

hyperinsulinemic hypoglycemia familial 3	hyperinsulinemic hypoglycemia, familial, 5
hyperinsulinemic hypoglycemia, familial, 1	hyperinsulinemic hypoglycemia, familial, 4

Diseases related to hyperinsulinemic hypoglycemia familial 2 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 140)

id	Related Disease	Score	Top Affiliating Genes
1	hypoglycemia	12.6
2	hypoglycemia of infancy	9.1
3	diabetes mellitus	8.7
4	persistent hyperinsulinemic hypoglycemia of infancy	8.6
5	exercise-induced hyperinsulinemic hypoglycemia	8.6
6	hyperinsulinemic hypoglycemia familial 3	8.6
7	pancreatitis	8.2
8	hyperinsulinism-hyperammonemia syndrome	8.1
9	hyperinsulinemic hypoglycemia, familial, 4	8.1
10	hyperinsulinemic hypoglycemia, familial, 1	8.1
11	hyperinsulinemic hypoglycemia, familial, 5	8.1
12	islet cell tumor	7.9
13	carcinoma	7.4
14	leucine-sensitive hypoglycemia of infancy	7.3
15	glud1-related hyperinsulinism	7.2
16	hyperinsulinemic hypoglycemia	7.2
17	insulin resistance	7.1
18	type 1 diabetes mellitus	7.1
19	hemangiopericytoma	7.1
20	insulinoma	7.1
21	glycogen storage disease	6.9
22	hyperglycemia	6.9
23	glycogen storage disease type 0	6.4
24	gastrointestinal stromal tumor	6.4
25	hyperinsulinism	6.4
26	maturity-onset diabetes of the young	6.4
27	hypoglycemia due to pck1 deficiency	6.0
28	hypoglycemia with deficiency of glycogen synthetase in the liver	6.0
29	hypoketonemic hypoglycemia	6.0
30	hypoxia	6.0
31	insulin autoimmune syndrome	6.0
32	ischemia	6.0
33	lactic acidosis	6.0
34	neuronitis	6.0
35	alcoholism	6.0
36	anorexia nervosa	6.0
37	arthritis	6.0
38	beckwith-wiedemann syndrome	6.0
39	carnitine-acylcarnitine translocase deficiency	6.0
40	hepatitis	6.0
41	hepatocellular carcinoma	6.0
42	histiocytoma	6.0
43	glycogen storage disease type ia	5.5
44	hereditary fructose intolerance syndrome	5.5
45	malignant fibrous histiocytoma	5.5
46	meninges hemangiopericytoma	5.5
47	meningitis	5.5
48	neuroendocrine tumor	5.5
49	obesity	5.5
50	rheumatoid arthritis	5.5

Clinical features from OMIM: 601820

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dextrose, dextrose 100% pwdr [va product], glucagon, glucose, glucose liquid

Genes related to hyperinsulinemic hypoglycemia familial 2 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	11.0	Disorders