MCID: HYP159
MIFTS: 17

Hyperinsulinism, Focal malady

Summaries for Hyperinsulinism, Focal

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MalaCards: Hyperinsulinism, Focal is related to beckwith-wiedemann syndrome and insulin resistance. An important gene associated with Hyperinsulinism, Focal is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are Regulation of Insulin Secretion and Potassium Channels. The compounds minoxidil and cibenzoline have been mentioned in the context of this disorder.

Aliases & Classifications for Hyperinsulinism, Focal

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42NIH Rare Diseases
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Aliases & Descriptions:

hyperinsulinism, focal 42


Related Diseases for Hyperinsulinism, Focal

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Hyperinsulinism, Focal:



Diseases related to hyperinsulinism, focal

Clinical Features for Hyperinsulinism, Focal

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Drugs & Therapeutics for Hyperinsulinism, Focal

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hyperinsulinism, Focal

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Anatomical Context for Hyperinsulinism, Focal

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Animal Models for Hyperinsulinism, Focal or affiliated genes

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Publications for Hyperinsulinism, Focal

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Genetic Variations for Hyperinsulinism, Focal

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Expression for genes affiliated with Hyperinsulinism, Focal

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperinsulinism, Focal

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Pathways for genes affiliated with Hyperinsulinism, Focal

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53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Hyperinsulinism, Focal

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Hyperinsulinism, Focal according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1minoxidil44 28 1112.3ABCC8
2cibenzoline449.5ABCC8, KCNJ11
3nicorandil44 2810.5ABCC8, KCNJ11
4mgadp449.5KCNJ11, ABCC8
5cromakalim44 2810.5ABCC8, KCNJ11
6repaglinide44 49 1111.4KCNJ11, ABCC8
7glimepiride44 49 1111.4ABCC8, KCNJ11
8gliclazide44 49 1111.4ABCC8, KCNJ11
9Glyburide119.4KCNJ11, ABCC8
10sulfonylurea449.4ABCC8, KCNJ11
11katp449.4KCNJ11, ABCC8
12diazoxide44 59 28 1112.4ABCC8, KCNJ11
13tolbutamide44 49 28 1112.3ABCC8, KCNJ11
14glibenclamide44 28 49 5912.3KCNJ11, ABCC8
15metformin44 49 1111.3ABCC8, KCNJ11
16pip2449.2KCNJ11, ABCC8
17potassium44 11 2411.2ABCC8, KCNJ11
18lysine449.1ABCC8, KCNJ11
19magnesium44 11 2411.1ABCC8, KCNJ11
20leucine449.0KCNJ11, ABCC8
21aspartate448.8KCNJ11, ABCC8

GO Terms for genes affiliated with Hyperinsulinism, Focal

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16Gene Ontology
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Cellular components related to Hyperinsulinism, Focal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:0080769.1ABCC8, KCNJ11

Biological processes related to Hyperinsulinism, Focal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium ion transmembrane transportGO:0718059.1ABCC8, KCNJ11
2synaptic transmissionGO:0072689.1ABCC8, KCNJ11
3regulation of insulin secretionGO:0507969.0ABCC8, KCNJ11
4energy reserve metabolic processGO:0061128.8ABCC8, KCNJ11

Molecular functions related to Hyperinsulinism, Focal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.1ABCC8, KCNJ11

Products for genes affiliated with Hyperinsulinism, Focal

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperinsulinism, Focal

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet