MCID: HYP159
MIFTS: 9

Hyperinsulinism, Focal malady

Categories: Rare diseases

Aliases & Classifications for Hyperinsulinism, Focal

Aliases & Descriptions for Hyperinsulinism, Focal:

Name: Hyperinsulinism, Focal 50

Classifications:



Summaries for Hyperinsulinism, Focal

MalaCards based summary : Hyperinsulinism, Focal is related to hyperinsulinism. The drugs Zinc and Heparin have been mentioned in the context of this disorder.

Related Diseases for Hyperinsulinism, Focal

Diseases related to Hyperinsulinism, Focal via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 hyperinsulinism 9.8

Symptoms & Phenotypes for Hyperinsulinism, Focal

Drugs & Therapeutics for Hyperinsulinism, Focal

Drugs for Hyperinsulinism, Focal (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Saxagliptin Approved Phase 4 361442-04-8 11243969
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5
Mirabegron Approved Phase 4 223673-61-8
6 insulin Phase 4,Phase 3,Phase 2,Phase 1
7 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1
9 Antioxidants Phase 4
10 calcium heparin Phase 4
11
protease inhibitors Phase 4,Early Phase 1
12 N-monoacetylcystine Phase 4
13 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Early Phase 1
14 Soybean oil, phospholipid emulsion Phase 4
15 HIV Protease Inhibitors Phase 4,Early Phase 1
16 Hormone Antagonists Phase 4
17 Dipeptidyl-Peptidase IV Inhibitors Phase 4
18 Hormones Phase 4
19 Parenteral Nutrition Solutions Phase 4
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
21 Pharmaceutical Solutions Phase 4
22 Expectorants Phase 4
23 Anti-Infective Agents Phase 4
24 Fat Emulsions, Intravenous Phase 4
25 Fibrinolytic Agents Phase 4
26 Anticoagulants Phase 4
27 Protective Agents Phase 4,Early Phase 1
28 Incretins Phase 4
29 Antidotes Phase 4
30 Respiratory System Agents Phase 4
31 Antiviral Agents Phase 4
32 Calcium, Dietary Phase 4
33 Adrenergic Agents Phase 4,Early Phase 1
34 Adrenergic Agonists Phase 4
35 Adrenergic beta-3 Receptor Agonists Phase 4
36 Adrenergic beta-Agonists Phase 4
37 Soy Bean Nutraceutical Phase 4
38
Menthol Approved Phase 3 2216-51-5 16666
39
Insulin Glargine Approved Phase 3 160337-95-1
40 Glucagon-Like Peptide 1 Phase 3
41 Grape Nutraceutical Phase 2, Phase 3
42 Anthocyanidin Nutraceutical Phase 2, Phase 3
43 Blueberry Nutraceutical Phase 2, Phase 3
44
Dopamine Approved Phase 2,Phase 1 51-61-6, 62-31-7 681
45
Diazoxide Approved Phase 2 364-98-7 3019
46
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
47
Pancrelipase Approved Phase 2 53608-75-6
48 Liver Extracts Phase 1, Phase 2
49 Antipsychotic Agents Phase 2
50 Dihydroxyphenylalanine Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 77)
id Name Status NCT ID Phase
1 Saxagliptin and Atherosclerosis Completed NCT01552018 Phase 4
2 Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion Completed NCT00188773 Phase 4
3 Weight Loss Improves Renal Hemodynamics Completed NCT01356394 Phase 4
4 The DINE Study-Diet Intervention to Negate Diabetes Study (Improving Weight Loss Outcomes for African Americans) Completed NCT00599040 Phase 4
5 Mirabegron and Brown Adipose Tissue Recruiting NCT03012113 Phase 4
6 Feasibility of Once/Daily Administered GLP/1 Receptoragonist (Lixisenatide) in Combination With Basal Insulin Completed NCT02168491 Phase 3
7 The Improvements of Dietary Supplement of Black Rice on Metabolic Syndrome Completed NCT02407522 Phase 2, Phase 3
8 A Pilot Study of a Lifestyle Intervention on the Metabolic Syndrome (3ELM Study) Unknown status NCT02233088 Phase 1, Phase 2
9 Dietary Modulation of Gene Expression and Metabolic Pathways in Glucose Metabolism Completed NCT00573781 Phase 2
10 Reducing Weight and Diabetes Risk in an Underserved Population (STRIDE) Completed NCT00790517 Phase 2
11 Partnership Programs to Reduce Cardiovascular Disparities- Morehouse- Emory Partnership Completed NCT00336869 Phase 2
12 Mood and Insulin Resistance in Adolescents At-Risk for Diabetes Completed NCT01425905 Phase 2
13 Transplantation of Microbes for Treatment of Metabolic Syndrome & NAFLD Recruiting NCT02496390 Phase 1, Phase 2
14 Phase II Safety and Efficacy Study of F-DOPA PET/CT in Children With Hyperinsulinemic Hypoglycemia Active, not recruiting NCT01468454 Phase 2
15 Utility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism Active, not recruiting NCT00674440 Phase 2
16 A Study in Type 2 Diabetic Patients With Repeated Doses of E1 in Combination With G1 Completed NCT00239187 Phase 1
17 Fluorodopa F 18 in Congenital Hyperinsulinism Recruiting NCT02021604 Phase 1
18 Mechanisms of Cerebrovascular Control Recruiting NCT02936687 Phase 1
19 Long Term Glucose Metabolism in Conservatively Treated Patients With Congenital Hyperinsulinism Unknown status NCT01819584
20 Effects of Dietary Fiber on Insulin Sensitivity Unknown status NCT01521806
21 Muscle Insulin Resistance In Aging Unknown status NCT01808924
22 Meta-analysis of Fructose-Containing Sugar Sweetened Beverages (SSBs) and Weight Change Unknown status NCT01608607
23 Cardiovascular Risk Factors After Renal Transplantation in Children and Adults Unknown status NCT01008306
24 Dipeptide Alanyl Glutamine and Postoperative Insulin Resistance in Colon Carcinoma Patients Unknown status NCT00922688
25 Low Carbohydrate Diet: The Effects on Non Alcoholic Fatty Liver Disease in Obese Teens With Metabolic Syndrome Unknown status NCT02358928
26 Pharmacogenetic Profiling of Antipsychotics-Induced X-Syndrome and Diabetes (PAXD) Unknown status NCT00201292
27 Feasibility Study - Integrated Sensor and Infusion Set. Trial III Completed NCT01773668
28 Walking and Dietary Modification for Recurrent Early Miscarriages Completed NCT03023137
29 Role of Colonic Events on Metabolism and Appetite Control: A Synbiotic Approach Completed NCT01718418 Early Phase 1
30 Effects of Dietary Fibre on Glucose Metabolism and Satiety Completed NCT02093481 Early Phase 1
31 Over-night Effect of Dietary Fiber on Glucose Metabolism and Satiety Completed NCT02347293 Early Phase 1
32 A Family Based Intervention to Reduce the Risk of Type 2 Diabetes in Children Completed NCT01146314
33 Fat Metabolism in Pregnancy and Neonatal Heart Function in Diabetes Completed NCT01346527
34 A Simple Dietary Message to Improve Dietary Quality for Metabolic Syndrome Completed NCT00911885
35 Environmental Triggers Of Cardiometabolic Disease Completed NCT01548300
36 Pharmacist - Physician Collaborative Approach to the Management of Metabolic Syndrome Completed NCT01099306
37 Resistant Starch Insulin Sensitivity Trial Completed NCT01027325
38 Magnesium and Vascular Stiffness Completed NCT02235805
39 "Can Soluble-CD163 Discriminate Between Healthy and Unhealthy Obese Individuals?" Completed NCT01463449
40 Bioactive Plant Foods: Effects on Functional Bioavailability and Genomic Stability Completed NCT00963118
41 Lifestyle Intervention for Pakistani Women in Oslo Completed NCT00425269
42 Body Weight and Vascular Function Completed NCT01675401
43 SIT LESS 3: The Effect of Low Intensity Physical Activity on Insulin Sensitivity, Mood and Cognitive Performance Completed NCT02394249
44 Exercise-Induced Epigenetic Modifications in Obese Aging Women Completed NCT01977885
45 The Flamenco (Fitness League Against MENopause COsts) Project Completed NCT02358109
46 Diet and Well-being of Young Danish Children Completed NCT02170428
47 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
48 Metabolic Syndrome and Gen-polymorphs Influence on Weightloss Among Children in Treatment for Overweight Completed NCT00823277
49 Exercise Capacity and Dyspnea in Obese Patients With Metabolic Syndrome: Effects of Weight Loss Completed NCT03035149
50 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273

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Pathways for Hyperinsulinism, Focal

GO Terms for Hyperinsulinism, Focal

Sources for Hyperinsulinism, Focal

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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