HYPLIP1
MCID: HYP614
MIFTS: 50

Hyperlipidemia, Familial Combined (HYPLIP1) malady

Categories: Genetic diseases (common), Metabolic diseases

Aliases & Classifications for Hyperlipidemia, Familial Combined

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Aliases & Descriptions for Hyperlipidemia, Familial Combined:

Name: Hyperlipidemia, Familial Combined 52 39 68
Hyperlipidemia, Familial Combined, Susceptibility to 24 27 12
Hyperlipidemia, Combined, 1 24 27 68
Mixed Hyperlipidemia 11 50 68
Combined Hyperlipidemia, Familial 52 12
Familial Combined Hyperlipidemia 11 13
Hyperlipidemia Combined 1 24 70
Hyperbetalipoproteinemia with Prebetalipoproteinemia 11
 
Familial Multiple Lipoprotein-Type Hyperlipidemia 11
Familial Combined Hyperlipidemia Type 1 70
Hyperlipidemia Familial Combined 50
Type Iib Hyperlipoproteinemia 11
Hyperlipoproteinemia Type Iib 68
Mixed Hyperlipidaemia 11
Hyplip1 70
Fchl1 70

Characteristics:

HPO:

64
combined hyperlipidemia, familial:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

Disease Ontology11 DOID:13809
ICD1030 E78.4, E78.2
MeSH39 D006950
MedGen37 C1865289

Summaries for Hyperlipidemia, Familial Combined

About this section
OMIM:52 Goldstein et al. (1973) gave the designation 'familial combined hyperlipidemia' to the most common genetic form of... (144250) more...

MalaCards based summary: Hyperlipidemia, Familial Combined, also known as hyperlipidemia, familial combined, susceptibility to, is related to hypertriglyceridemia and hyperchylomicronemia, late-onset, and has symptoms including xanthelasma, myocardial infarction and combined hyperlipidemia. An important gene associated with Hyperlipidemia, Familial Combined is LPL (Lipoprotein Lipase), and among its related pathways are Vitamin digestion and absorption and Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Affiliated tissues include heart, and related mouse phenotypes are Increased LDL uptake and Decreased free cholesterol.

UniProtKB/Swiss-Prot:70 Hyperlipidemia combined 1: A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease.

Description from OMIM:52 602491

Related Diseases for Hyperlipidemia, Familial Combined

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Diseases in the Hyperlipidemia, Familial Combined family:

Hyperlipidemia, Combined, 2

Diseases related to Hyperlipidemia, Familial Combined via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1hypertriglyceridemia28.8APOA1, APOA2, APOB, APOC3, APOE, LIPC
2hyperchylomicronemia, late-onset11.0
3alport syndrome and thin basement membrane nephropathy10.3APOE, LPL
4zap-70 deficiency10.2APOB, APOE
5keratoconus 410.2APOB, APOE
6dentinogenesis imperfecta type 210.2APOB, APOE, HMGCR
7transient retinal arterial occlusion10.2APOA1, APOB, HMGCR
8spinocerebellar ataxia 2010.2APOA1, APOB, HMGCR
9myxofibrosarcoma10.1APOE, LPL
10gait apraxia10.1APOA1, APOB, APOE
11pars planitis10.1APOA1, APOE
12polycystic kidney disease, infantile severe, with tuberous sclerosis10.1LIPC, LPL
13dyserythropoietic anemia, congenital, type ii10.1APOA1, APOC3, APOE
14hyperlipidemia type 310.1
15mannosidosis, beta10.1APOA1, APOB, APOE, LPL
16alzheimer disease 19, late onset10.1APOA2, APOB, APOE
17tyrosinemia, type ii10.1APOA1, APOA2
18familial progressive cardiac conduction defect10.1APOA1, APOA2, APOE
19cetp-related hyperalphalipoproteinemia10.1APOB, APOE, INS
20fetal warfarin syndrome10.1APOA1, APOB, INS
21cataract 20, multiple types10.1APOB, INS, LPL
22abducens nerve neoplasm10.0APOA5, LIPC, LPL
23albinism, oculocutaneous, type v10.0APOA1, APOA2, APOB, APOE
24primary pigmented nodular adrenocortical disease10.0APOA1, APOB, APOE, INS
25neuropathy, hereditary sensory and autonomic, type ia10.0APOA1, APOA2, APOB, APOE
26hard palate cancer10.0APOA1, APOA2, APOE
27c1s deficiency10.0APOA5, APOE, INS, LPL
28cervix small cell carcinoma10.0APOA1, APOB, APOE, INS
29hyperchlorhidrosis, isolated9.9APOA1, APOE, LIPC, LPL
30hereditary lymphedema type ii9.9APOA1, APOA2
31exudative vitreoretinopathy 2, x-linked9.9APOB, COG2
32joint disorders9.9APOA1, APOB, APOE, INS, LPL
33bird fancier's lung9.9APOA1, APOA2, APOB, APOE, LPL
34hyperlipoproteinemia type iv9.9APOB, COG2, INS
35severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome9.9APOB, APOE, HMGCR, LIPC, LPL
36acute pancreatitis9.9
37pancreatitis9.9
38recurrent acute pancreatitis9.9
39optic nerve neoplasm9.8APOA1, APOB, APOE, COG2
40coronary artery disease9.8
41artery disease9.8
42budd-chiari syndrome9.8APOB, APOE, COG2, HMGCR
43adrenal adenoma9.8APOB, COG2, INS
44peroneal neuropathy9.8APOB, COG2, INS
45pericarditis9.8APOA1, APOB, APOE, HMGCR, INS, LPL
46chondrocalcinosis with early-onset osteoarthritis9.8APOA1, APOB, APOC3, APOE, INS, LPL
47von willebrand disease, platelet-type9.8APOA1, APOA2, APOB, APOC3, APOE, LPL
48body dysmorphic disorder9.8APOA1, APOB, COG2, INS
49hypopituitarism9.7
50posterior uveal melanoma9.7APOA1, APOB, COG2, INS, USF1

Comorbidity relations with Hyperlipidemia, Familial Combined via Phenotypic Disease Network (PDN):


Hypertension, EssentialPeripheral Vascular Disease
Chronic Myocardial IschemiaIschemic Heart Disease
Benign Essential HypertensionEsophagitis
HypothyroidismMitral Valve Disease
Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Hyperlipidemia, Familial Combined:



Diseases related to hyperlipidemia, familial combined

Symptoms & Phenotypes for Hyperlipidemia, Familial Combined

About this section

Symptoms by clinical synopsis from OMIM:

144250

Clinical features from OMIM:

602491,144250

Human phenotypes related to Hyperlipidemia, Familial Combined:

 64
id Description HPO Frequency HPO Source Accession
1 xanthelasma64 HP:0001114
2 myocardial infarction64 HP:0001658
3 combined hyperlipidemia64 HP:0008356

GenomeRNAi Phenotypes related to Hyperlipidemia, Familial Combined according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00340-A-110.4APOA1, APOE, LPL
2GR00340-A-28.5APOA1, APOA5, APOB, APOC3, APOE, HMGCR

MGI Mouse Phenotypes related to Hyperlipidemia, Familial Combined according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8APOA1, APOB, APOE, HMGCR, INS, LIPE
2MP:00053698.3APOB, APOE, INS, LIPE, LPL, RXRG
3MP:00053766.5APOA1, APOA2, APOA5, APOB, APOE, COG2

Drugs & Therapeutics for Hyperlipidemia, Familial Combined

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Drugs for Hyperlipidemia, Familial Combined (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 84)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EzetimibeapprovedPhase 4, Phase 3279163222-33-1150311
Synonyms:
(-)-Sch 58235
(1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone)
(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
(3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-(4-hydroxyphenyl)-2-azetidione
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone
163222-33-1
AC-1057
AC1L442L
C108606
CHEBI:49040
CHEMBL1138
CID150311
CPD000466334
D01966
DB00973
Essex brand of ezetimibe
Ezedoc
Ezetimiba
Ezetimibe
Ezetimibe (JAN/USAN/INN)
Ezetimibe [USAN:INN]
Ezetimibum
 
Ezetrol
HMS2051K16
LS-181801
MK-0653
MLS000759443
MLS001424125
MSD brand of ezetimibe
Merck brand of ezetimibe
MolPort-005-938-627
S1655_Selleck
SAM001246623
SCH-58235
SCH58235
SMR000466334
STK640490
STOCK6S-73750
Sch 58235
Schering-Plough brand of ezetimibe
UNII-EOR26LQQ24
ZINC03810860
Zetia
Zetia (TN)
Zetia , Ezetrol, Ezetimibe
Zient
ezetimib
2
FenofibrateapprovedPhase 4, Phase 317049562-28-93339
Synonyms:
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
49562-28-9
AB00052196
AC-4227
AC1L1FPK
AKOS005107777
AZU, Fenofibrat
AbZ Brand of Procetofen
Abbott Brand of Procetofen
Aliud Brand of Procetofen
Ankebin
Antara
Antara (TN)
Antara (micronized)
Antara Micronized Procetofen
Anto Brand of Procetofen
Apo Feno Micro
Apo Fenofibrate
Apo-Feno-Micro
Apo-Fenofibrate
Apotex Brand of Procetofen
Azupharma Brand of Procetofen
BIDD:GT0574
BPBio1_000166
BRD-K50388907-001-05-6
BRN 2062462
BSPBio_000150
BSPBio_003162
Bouchara Brand of Procetofen
C07586
C20H21ClO4
CAS-49562-28-9
CCRIS 7282
CHEBI:5001
CHEMBL672
CID3339
CIP-Fenofibrate
CPD000058299
Controlip
D00565
D011345
DB01039
Debat, Fenofibrate
DivK1c_000557
EINECS 256-376-3
EU-0100486
Elasterate
Elasterin
F 6020
F6020_SIGMA
FENOFIBRATE (MICRONIZED)
FNF
Fenobeta
Fenobrate
Fenofanton
Fenofibrat AL
Fenofibrat AZU
Fenofibrat AbZ
Fenofibrat FPh
Fenofibrat Heumann
Fenofibrat Hexal
Fenofibrat Stada
Fenofibrat ratiopharm
Fenofibrat-ratiopharm
Fenofibrate
Fenofibrate (JAN/INN)
Fenofibrate Debat
Fenofibrate IDD-P
Fenofibrate MSD
Fenofibrate [INN:BAN]
Fenofibrato
Fenofibrato [INN-Spanish]
Fenofibratum
Fenofibratum [INN-Latin]
Fenofibric acid
Fenogal
Fenoglide
Fenomax
Fenotard
Finofibrate
Fournier Brand of Procetofen
Fulcro
GNR Pharma Brand of Procetofen
GNR-Pharma Brand of Procetofen
GRS-027
Gate Brand of Procetofen
Gen Fenofibrate
Gen-Fenofibrate
Genpharm Brand of Procetofen
HMS1568H12
HMS1921B17
HMS2090G20
HMS2092B05
HMS501L19
Heumann Brand of Procetofen
Heumann, Fenofibrat
Hexal Brand of Procetofen
Hexal, Fenofibrat
I06-0048
IDI1_000557
Isopropyl (4'-(P-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
KBio1_000557
KBio2_001730
KBio2_004298
KBio2_006866
KBio3_002382
KBioGR_000706
KBioSS_001730
Knoll Brand of Procetofen
LCP-Feno
LCP-FenoChol
LF 178
 
LF-178
LF178
LS-121256
Lichtenstein Brand of Procetofen
Lipanthyl
Lipantil
Lipantil (TN)
Liparison
Lipidex
Lipidil
Lipidil Micro
Lipidil Supra
Lipidil Ter
Lipidil-Ter
Lipifen
Lipirex
Lipoclar
Lipofen
Lipofen (TN)
Lipofene
Liposit
Lipsin
Lofibra
Lopac-F-6020
Lopac0_000486
Luxacor
MLS000028515
MLS001148191
MTW Brand of Procetofen
MTW Fenofibrat
MTW-Fenofibrat
Merck dura Brand of Procetofen
Micronized Procetofen, Antara
MolPort-002-887-051
NCGC00015437-01
NCGC00015437-02
NCGC00015437-03
NCGC00015437-06
NCGC00015437-12
NCGC00021475-03
NCGC00021475-04
NCGC00021475-05
NCGC00021475-06
NCGC00021475-07
NCGC00021475-08
NINDS_000557
NSC 281319
NSC281319
Nolipax
Novartis Brand of Procetofen
Novo Fenofibrate
Novo-Fenofibrate
Novopharm Brand of Procetofen
Nu Fenofibrate
Nu Pharm Brand of Procetofen
Nu-Fenofibrate
Nu-Pharm Brand of Procetofen
PMS Fenofibrate Micro
PMS-Fenofibrate Micro
Pharmascience Brand of Procetofen
Pharmavit
Phenofibrate
Prestwick0_000275
Prestwick1_000275
Prestwick2_000275
Prestwick3_000275
Prestwick_217
Procetofen
Procetofen Reliant Brand
Procetofen, Antara Micronized
Procetofene
Proctofene
Protolipan
Q Pharm Brand of Procetofen
Q-Pharm Brand of Procetofen
Reliant Brand of Procetofen
S1794_Selleck
SAM002264613
SMR000058299
SPBio_001380
SPBio_002369
SPECTRUM1501010
ST085313
Schering Plough Brand of Procetofen
Schering-Plough Brand of Procetofen
Secalip
Sedufen
Spectrum2_001390
Spectrum3_001431
Spectrum4_000413
Spectrum5_001479
Spectrum_001250
Stada, Fenofibrat
Stadapharm Brand of Procetofen
Supralip
TL8003296
TRICOR (MICRONIZED)
Tricor
Tricor (TN)
Triglide
Triglide (TN)
Trilipix
UNII-U202363UOS
United Drug Brand of Procetofen
ZINC00584092
betapharm Brand of Procetofen
ct Arzneimittel Brand of Procetofen
ct-Arzneimittel Brand of Procetofen
durafenat
fenofibrat von ct
fenofibrate
fenofibric acid
isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
nchembio790-comp24
ratiopharm Brand of Procetofen
3
SimvastatinapprovedPhase 4, Phase 351979902-63-954454
Synonyms:
(+)-Simvastatin
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
79902-63-9
AC-1530
AC1L1H1F
AKOS005111006
ARONIS24119
BCBcMAP01_000007
BIDD:GT0769
BPBio1_001001
BRD-K22134346-001-05-8
BRN 4768037
BSPBio_000909
BSPBio_002337
Bio-0672
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
C25H38O5
CCRIS 7558
CHEBI:9150
CHEMBL1064
CID54454
CPD000718785
Cholestat
Coledis
Colemin
Corolin
D00434
D019821
DRG-0320
Denan
DivK1c_006991
Eucor
HMS1570N11
HMS1922H13
HMS2089D12
HMS2093E06
HSDB 7208
InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
KBio1_001935
KBio2_002197
KBio2_004765
KBio2_007333
KBio3_001557
KBioGR_001244
KBioSS_002197
KS-1113
Kolestevan
L 644128-000U
LS-46264
Labistatin
Lipex
Lipinorm
Liponorm
Lipovas
Lodales
MK 0733
MK 733
MK-0733
MK-733
MK733
MLS001304029
MLS001333077
MLS001333078
 
MLS002154038
Medipo
Modutrol
MolPort-002-507-345
MolPort-002-885-862
NCGC00017324-01
NCGC00017324-02
NCGC00017324-03
Nivelipol
Nor-Vastina
Pantok
Pepstatin
Prestwick0_000865
Prestwick1_000865
Prestwick2_000865
Prestwick3_000865
Prestwick_171
Rechol
Rendapid
S1792_Selleck
S6196_SIGMA
SAM002589969
SMR000718785
SPBio_001881
SPBio_002830
SPECTRUM1504236
STK801938
Simcor
Simovil
Simvast CR
Simvastatin
Simvastatin & Primycin
Simvastatin (JAN/USP/INN)
Simvastatin [USAN:INN:BAN]
Simvastatin [Usan:Ban:Inn]
Simvastatin lactone
Simvastatin, Compactin
Simvastatina
Simvastatina [Spanish]
Simvastatine
Simvastatine [French]
Simvastatinum
Simvastatinum [Latin]
Simvotin
Sinvacor
Sinvascor
Sivastin
SpecPlus_000895
Spectrum2_001671
Spectrum3_000669
Spectrum4_000632
Spectrum5_001428
Spectrum_001717
Statin
Synvinolin
TNP00259
UNII-AGG2FN16EV
Valemia
Vasotenal
Velostatin
Vytorin
ZINC03780893
Zocor
Zocor (TN)
Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin
Zocord
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta
nchembio790-comp16
simvastatin
4
SpironolactoneapprovedPhase 42321952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
5
Lovastatinapproved, investigationalPhase 46375330-75-553232
Synonyms:
(1S,3R,7S,8S,8AR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
1cqp
2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
6 Methylcompactin
6 alpha-Methylcompactin
6-Methylcompactin
6-alpha-Methylcompactin
6-alpha-methylcompactin
6alpha-Methylcompactin
6α-methylcompactin
71949-96-7
74133-25-8
75330-75-5
81739-26-6
AC-13961
AC1L1EI6
AC1Q2C7T
ACon0_000534
ACon1_000390
ARONIS24208
Altocor
Altoprev
Artein
BB_NC-1457
BIDD:GT0749
BIDD:PXR0113
BPBio1_000519
BRD-K09416995-001-06-8
BRN 3631989
BSPBio_000471
BSPBio_001265
BSPBio_003346
Belvas
C07074
C24H36O5
CCRIS 8092
CHEBI:40303
CHEMBL503
CID53232
CPD-5561
CPD000673570
Cholestra
Closterol
Colevix
D00359
D008148
DB00227
DivK1c_001032
HMS1569H13
HMS1792O07
HMS1923O13
HMS1990O07
HMS2089M06
HMS2093O03
HMS503O05
HSDB 6534
Hipolip
Hipovastin
I06-1876
IDI1_001032
KBio1_001032
KBio3_002848
L-154803
L0214
LOVASTATIN
LS-46359
Lestatin
Lipdip
Lipivas
Lipofren
Liposcler
 
Lovalip
Lovalord
Lovastatin & Primycin
Lovastatin (USP/INN)
Lovastatin [USAN:BAN:INN]
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha-Isomer (without R*/S* notation)
Lovastatina
Lovastatina [Spanish]
Lovastatine
Lovastatine [French]
Lovastatinum
Lovastatinum [Latin]
Lovasterol
Lovastin
Lozutin
M2147_SIGMA
MEGxm0_000398
MK 803
MK-803
MK803
ML-530B
ML-530b
MLS000069585
MLS001055358
MSD 803
Mevacor
Mevacor (TN)
Mevinacor
Mevinolin
Mevinolin from Aspergillus sp.
Mevlor
MolPort-001-739-990
Monacolin K
Monacolin-K
Monakolin K
NCGC00023509-03
NCGC00023509-04
NCGC00023509-05
NCGC00023509-06
NCGC00023509-07
NCGC00023509-08
NINDS_001032
Nergadan
Paschol
Prestwick0_000516
Prestwick1_000516
Prestwick2_000516
Prestwick3_000516
Prestwick_819
Rextat
Rodatin
Rovacor
SAM002589963
SMR000058779
SMR000673570
SPBio_002392
SPECTRUM1503977
STK801953
Sivlor
Spectrum3_001873
Spectrum5_001294
Taucor
Tecnolip
Teroltrat
UNII-9LHU78OQFD
ZINC03812841
lovastatin
lovastatin lactone
nchembio742-comp5
nchembio790-comp14
nchembio869-comp12
6
AmlodipineapprovedPhase 449688150-42-92162
Synonyms:
()-Amlodipine
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (.+/-.)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
88150-42-9
88150-47-4 (maleate (1:1))
AC-4535
AC1L1D26
AC1Q32ZS
AMLODIPINE BASE
AMVAZ
Ambap88150-42-9
Amlocard
Amlodipine
Amlodipine (INN)
Amlodipine Benzenesulfonate
Amlodipine Besilate
Amlodipine Besylate
Amlodipine Free Base
Amlodipine [INN:BAN]
Amlodipine besilate
Amlodipine besylate
Amlodipine free base
Amlodipino
Amlodipino [Spanish]
Amlodipinum
Amlodipinum [Latin]
Amlodis
Amlopres
Amlor
 
Amvaz
BIDD:GT0810
BRD-A22032524-074-02-4
BRD-A22032524-074-03-2
BSPBio_002727
C06825
CHEBI:2668
CHEMBL1491
CID2162
CPD000469198
Coroval
D07450
DB00381
HMS2052N03
HMS2089H07
I14-0798
Intervask
Istin
KBio3_001947
KBioGR_001643
LS-131183
Lipinox
Lotrel
MLS001401409
MolPort-001-792-963
NCGC00165957-01
NCGC00165957-02
NCGC00165957-03
Norvasc
Norvasc (TN)
Pelmec
R,S)-Amlodipine
Racemic Amlodipine
SAM001246705
SMR000469198
SPBio_000351
Spectrum2_000486
Spectrum3_001004
Spectrum4_001132
Spectrum5_001550
UK-4834011
UNII-1J444QC288
amlodipine
7
Nicotinamideapproved, NutraceuticalPhase 4, Phase 3, Phase 2, Phase 191998-92-0936
Synonyms:
.beta.-Pyridinecarboxamide
11032-50-1
123574-63-0
1yc5
3 Pyridinecarboxamide
3-Carbamoylpyridine
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
37321-14-5
47865U_SUPELCO
55600-01-6
63748-44-7
72340_FLUKA
72340_SIGMA
72347_FLUKA
78731-47-2
98-92-0
A186B02E-6C70-4E54-9739-79398D439AAA
AC-907/25014114
AC1L1ACZ
AC1Q4ZFV
AI3-02906
Acid amide
Amid kyseliny nikotinove
Amid kyseliny nikotinove [Czech]
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Astra Brand of Niacinamide
Austrovit PP
B 3, Vitamin
B3, Vitamin
BB_NC-2290
Benicot
C00153
C6H6N2O
CCRIS 1901
CHEBI:17154
CHEMBL1140
CID936
CPD000058212
D00036
D009536
DB02701
DEA No. 1405
Delonin Amide
Delonin amide
Dipegyl
Dipigyl
EINECS 202-713-4
EINECS 234-265-0
Endobion
Enduramide
Factor pp
HMS2052M21
HMS2090B05
HMS2093H03
HSDB 1237
Hansamid
I02-1741
I02-2250
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Inovitan PP
Jenapharm Brand of Niacinamide
Jenapharm, Nicotinsaureamid
LS-2051
MLS000069714
Mediatric
Merck Brand of Niacinamide
MolMap_000061
MolPort-001-783-876
N0078
N0636_SIGMA
N2142_SIGMA
N3376_SIGMA
N5535_SIAL
NAM
NCGC00093354-03
NCGC00093354-04
NSC 13128
NSC13128
NSC27452
Nandervit-N
Niacevit
Niacinamide
Niacinamide (USP)
Niacinamide Astra Brand
Niacinamide Jenapharm Brand
Niacinamide Merck Brand
 
Niacinamide Pharmagenix Brand
Niacinamide [USAN]
Niacinamide, Nicotinic acid amide, Nicotinamide
Niacotinamide
Niamide
Niavit PP
Nicamide
Nicamina
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicosylamide
Nicota
Nicotamide
Nicotilamide
Nicotililamido
Nicotinamid
Nicotinamida
Nicotinamida [INN-Spanish]
Nicotinamide
Nicotinamide (JP15/INN)
Nicotinamide (Niacinamide)
Nicotinamide, niacin, vitamin B3
Nicotinamide-carbonyl-14C
Nicotinamidum
Nicotinamidum [INN-Latin]
Nicotine acid amide
Nicotine amide
Nicotinic acid amide
Nicotinic amide
Nicotinsaeureamid
Nicotinsaureamid
Nicotinsaureamid Jenapharm
Nicotinsaureamid [German]
Nicotol
Nicotylamide
Nicotylamidum
Nicovel
Nicovit
Nicovitina
Nicovitol
Nicozymin
Nictoamide
Nikasan
Nikazan
Niko-tamin
Nikotinamid
Nikotinsaeureamid
Nikotinsaeureamid [German]
Niocinamide
Niozymin
PP-Faktor
Papulex
Pelmin
Pelmine
Pelonin amide
Pharmagenix Brand of Niacinamide
Propamine A
Pyridine-3-carboxylic acid amide
S1899_Selleck
SAM001246860
SGCUT00176
SMR000058212
Savacotyl
UNII-25X51I8RD4
Vi-Nicotyl
Vi-noctyl
Vitamin B
Vitamin B (VAN)
Vitamin B 3
Vitamin B3 amide
Vitamin H1
Vitamin PP
WLN: T6NJ CVZ
Witamina PP
ZINC00005878
b-Pyridinecarboxamide
beta-Pyridinecarboxamide
bmse000281
m-(Aminocarbonyl)pyridine
nchembio.154-comp4
nchembio.73-comp6
niacin - Vitamin B3
niacinamide
nicotinamide
pyridine-3-carboxamide
to_000073
vitamin PP
8
Folic Acidapproved, nutraceutical, vet_approvedPhase 4, Phase 3, Phase 2, Phase 1439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
9
Niacinapproved, investigational, nutraceuticalPhase 4, Phase 3, Phase 2, Phase 192359-67-6938
Synonyms:
3-Carboxylpyridine
3-Carboxypyridine
3-Pyridinecarboxylate
3-Pyridinecarboxylic acid
3-Pyridylcarboxylate
3-Pyridylcarboxylic acid
3-carboxypyridine
Acide Nicotinique
Acido nicotinico
Acidum Nicotinicum
Akotin
Anti-pellagra vitamin
Apelagrin
Daskil
Efacin
Enduracin
Linic
M-Pyridinecarboxylic Acid
Niac
Niacin
Niacine
Niacor
Nicacid
Nicamin
Nicangin
 
Nico-Span
Nicobid
Nicocap
Nicodelmine
Nicolar
Niconacid
Nicosan 3
Nicotinate
Nicotinic Acid
Nicotinic acid
Nicotinipca
Nicyl
Nikotinsaeure
Nyclin
P.P. factor
PP Factor
Pellagra preventive factor
Pellagrin
Pelonin
Pyridine-beta-carboxylic acid
Slo-niacin
Vitamin B3
Wampocap
beta-Pyridinecarboxylic acid
pyridine-β-carboxylic acid
β-pyridinecarboxylic acid
10Anticholesteremic AgentsPhase 4, Phase 3, Phase 2, Phase 12025
11VitaminsPhase 4, Phase 3, Phase 2, Phase 15282
12Atorvastatin CalciumPhase 4, Phase 3760134523-03-8
13Vasodilator AgentsPhase 4, Phase 3, Phase 13543
14AntimetabolitesPhase 4, Phase 3, Phase 2, Phase 112054
15Vitamin B ComplexPhase 4, Phase 3, Phase 2, Phase 14337
16Lipid Regulating AgentsPhase 4, Phase 3, Phase 2, Phase 12766
17Trace ElementsPhase 4, Phase 3, Phase 2, Phase 16001
18Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 4, Phase 31998
19Calcium, DietaryPhase 4, Phase 35713
20MicronutrientsPhase 4, Phase 3, Phase 2, Phase 16001
21Hypolipidemic AgentsPhase 4, Phase 3, Phase 2, Phase 12785
22Nicotinic AcidsPhase 4, Phase 3, Phase 2, Phase 1923
23Rosuvastatin CalciumPhase 4, Phase 3476147098-20-2
24HormonesPhase 414415
25Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
26Mineralocorticoid Receptor AntagonistsPhase 4346
27Natriuretic AgentsPhase 41697
28Ezetimibe, Simvastatin Drug CombinationPhase 4, Phase 369
29Hormone AntagonistsPhase 413180
30MineralocorticoidsPhase 4367
31Amlodipine, atorvastatin drug combinationPhase 418
32L 647318Phase 463
33DihydromevinolinPhase 463
34Diuretics, Potassium SparingPhase 41917
35Angiotensin-Converting Enzyme InhibitorsPhase 4724
36Colesevelam HydrochloridePhase 448
37diureticsPhase 41418
38calcium channel blockersPhase 41985
39Antihypertensive AgentsPhase 44207
40FolateNutraceuticalPhase 4, Phase 3, Phase 2, Phase 14392
41Vitamin B3NutraceuticalPhase 4, Phase 3, Phase 2, Phase 1923
42Omega 3 Fatty AcidNutraceuticalPhase 4, Phase 3, Phase 11018
43Vitamin B9NutraceuticalPhase 4, Phase 3, Phase 2, Phase 14392
44
Ursodeoxycholic acidapproved, investigationalPhase 397128-13-231401
Synonyms:
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oate
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid
(3a,5b,7b)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid
(3α,5β,7β)-3,7-dihydroxycholan-24-oic acid
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
128-13-2
17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol
3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid
3,7-Dihydroxycholan-24-oic acid
3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid
3-alpha,7-beta-Dihydroxycholanic acid
3-alpha,7-beta-Dioxycholanic acid
3a,7b-Dihydroxy-5b-cholan-24-oate
3a,7b-Dihydroxy-5b-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholanic acid
4-10-00-01604 (Beilstein Handbook Reference)
50809-41-1
5beta-Cholan-24-oic acid-3alpha,7beta-diol
5beta-Cholanic Acid-3alpha,7beta-diol
7-beta-Hydroxylithocholic acid
7beta-Hydroxylithocholic acid
80225-86-1
AB00513977
AC-18919
AC-2081
AC1L1LJH
Acide ursodesoxycholique
Acide ursodesoxycholique [INN-French]
Acido ursodeossicolico
Acido ursodeossicolico [Italian]
Acido ursodeoxicolico
Acido ursodeoxicolico [INN-Spanish]
Acidum ursodeoxycholicum
Acidum ursodeoxycholicum [INN-Latin]
Actigall
Actigall (TN)
Antigall
Arsacol
BB_NC-2372
BPBio1_001052
BRN 3219888
BSPBio_000956
C07880
C24H40O4
CCRIS 5502
CHEBI:9907
CHEMBL1551
CHEMBL73390
CID11516715
CID31401
CPD-10534
CPD000058403
Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)- (9CI)
Cholit-ursan
D00734
DB01586
Delursan
Deoxyursocholic Acid
Destolit
Deursil
Dom-ursodiol c
EINECS 204-879-3
HMS1570P18
 
ISO-URSODEOXYCHOLIC ACID
IU5
LMST04010033
LS-53033
Litursol
Lyeton
MLS000028461
MLS001066373
MolPort-001-794-630
MolPort-005-932-884
NCGC00179363-01
NCI60_028904
NSC 657950
NSC 683769
PHL-ursodiol c
PMS-ursodiol c
Peptarom
Prestwick0_000958
Prestwick1_000958
Prestwick2_000958
Prestwick3_000958
S1643_Selleck
SAM002264653
SMP2_000012
SMR000058403
SPBio_003105
Sodium Ursodeoxycholate
Solutrat
U-9000
U0030
U5127_SIGMA
UDCA
UDCS
UNII-724L30Y2QR
URSODEOXYCHOLIC ACID
UrSO
Urosdesoxycholate
Urosdesoxycholic acid
Urosiol
Ursacholic Acid
Ursacol
Urso
Urso (TN)
Urso 250
Urso DS
Urso Forte
Ursobilin
Ursochol
Ursodamor
Ursodeoxy cholic acid
Ursodeoxycholate
Ursodeoxycholic acid
Ursodeoxycholic acid (JP15/INN)
Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol
Ursodeoxycholicacid
Ursodesoxycholic acid
Ursodexycholate
Ursodexycholic Acid
Ursodexycholic acid
Ursodiol
Ursodiol (USP)
Ursodiol [USAN]
Ursofalk
Ursolvan
Ursosan
chenodeoxycholic acid
ursodeoxycholate
ursodiol
45
BezafibrateapprovedPhase 31441859-67-039042
Synonyms:
2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid
2-(P-(2-(P-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
2-[4-(2-[4-Chlorobenzamido]ethyl)- phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]isobutyric Acid
2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
41859-67-0
AB00052265
AB1004588
AC-6817
AC1L20XS
AC1Q5E4V
AKOS005107743
Azufibrat
Azupharma Brand of Bezafibrate
B3346
B7273_SIGMA
BF-759
BM 15.075
BM 15075
BM-15.075
BM-15075
BM15.075
BPBio1_000589
BRD-K46018455-001-06-0
BRN 4267656
BSPBio_000535
BSPBio_001314
BSPBio_003119
Bayer Brand of Bezafibrate
Befibrat
Befizal
Berlin Chemie Brand of Bezafibrate
Berlin-Chemie Brand of Bezafibrate
Betapharm Brand of Bezafibrate
Beza Lande
Beza Puren
Beza-Lande
Beza-Puren
BezaLande
BezaPuren
Bezabeta
Bezacur
Bezafibrat
Bezafibrat PB
Bezafibrate (JP15/USAN/INN)
Bezafibrate Azupharma Brand
Bezafibrate Bayer Brand
Bezafibrate Berlin-Chemie Brand
Bezafibrate Betapharm Brand
Bezafibrate Cryopharma Brand
Bezafibrate Elfar Brand
Bezafibrate Hennig Brand
Bezafibrate Hexal Brand
Bezafibrate Isis Brand
Bezafibrate Lakeside Brand
Bezafibrate Merckle Brand
Bezafibrate Roche Brand
Bezafibrate Synthelabo Brand
Bezafibrate TAD Brand
Bezafibrate Teva Brand
Bezafibrate [USAN:BAN:INN:JAN]
Bezafibrato
Bezafibrato [INN-Spanish]
Bezafibrato [Spanish]
Bezafibrato [inn-spanish]
Bezafibratum
Bezafibratum [INN-Latin]
Bezafibratum [inn-latin]
Bezafisal
Bezalip
Bezalip Retard
Bezamerck
Bezatol
Bezatol SR
Bezatol SR (TN)
Bezatol sr (tn)
Bio2_000034
Bio2_000514
Boehringer Mannheim Brand of Bezafibrate
C19H20ClNO4
CAS-41859-67-0
CCRIS 9085
CHEBI:47612
 
CHEMBL264374
CID39042
Cedur
Cryopharma Brand of Bezafibrate
D001629
D01366
DB01393
DB08380
Difaterol
DivK1c_000092
EINECS 255-567-9
Elfar Brand of Bezafibrate
Eulitop
HMS1361B16
HMS1569K17
HMS1791B16
HMS1921H16
HMS1989B16
HMS2089F04
HMS2092B12
HMS500E14
Hennig Brand of Bezafibrate
Hexal Brand of Bezafibrate
I06-1311
IDI1_000092
IDI1_033784
Isis Brand of Bezafibrate
KBio1_000092
KBio2_000034
KBio2_001923
KBio2_002602
KBio2_004491
KBio2_005170
KBio2_007059
KBio3_000067
KBio3_000068
KBio3_002619
KBioGR_000034
KBioGR_000669
KBioSS_000034
KBioSS_001923
LO 44
LS-124535
Lakeside Brand of Bezafibrate
Lipox
MLS000028533
MLS001148205
Merckle Brand of Bezafibrate
MolPort-001-738-424
NCGC00016850-01
NCGC00016850-02
NCGC00016850-11
NCGC00023317-03
NCGC00023317-04
NCGC00023317-05
NCGC00023317-06
NCGC00023317-07
NCGC00023317-08
NINDS_000092
PB, Bezafibrat
Prestwick0_000378
Prestwick1_000378
Prestwick2_000378
Prestwick3_000378
Prestwick_724
Reducterol
Regadrin B
Roche Brand of Bezafibrate
SMR000058298
SPBio_000824
SPBio_002456
SPECTRUM1502046
ST51014927
Sklerofibrat
Solibay
Spectrum2_000922
Spectrum3_001500
Spectrum4_000325
Spectrum5_001079
Spectrum5_001967
Spectrum_001443
Synthelabo Brand of Bezafibrate
TAD Brand of Bezafibrate
Teva Brand of Bezafibrate
a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid
bezafibrate
durabezur
46
PravastatinapprovedPhase 315081093-37-054687
Synonyms:
(+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid
(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha))-1-Naphthaleneheptanoic acid
3beta-Hydroxycompactin
81093-37-0
81131-70-6 (hydrochloride salt)
AC1L1HJL
AC1Q5T3M
BIDD:GT0773
BRD-K60511616-236-01-4
C01844
C23H36O7
CCRIS 7557
CHEMBL1144
CID54687
Compactin
D08410
DB00175
Elisor
Eptastatin
FT-0082682
KS-5015
LS-94713
Lipostat
Mevalothin
Mevalotin
Mevastatin
Mevinolin
 
Oliprevin
Pravachol
Pravaselect
Pravastatin (INN)
Pravastatin Sodium
Pravastatin Sodium Salt
Pravastatin [INN:BAN]
Pravastatin acid
Pravastatin sodium
Pravastatin tert-Octylamine Salt
Pravastatina
Pravastatina [Spanish]
Pravastatine
Pravastatine [French]
Pravastatinum
Pravastatinum [Latin]
Pravator
Pravator (TN)
RMS-431
SQ-31,000
Selectin
Selektine
Selipran
UNII-KXO2KT9N0G
Vasten
nchembio.301-comp7
nchembio790-comp15
pravastatin
pravastatina
pravastatine
pravastatinum
47Antibodies, MonoclonalPhase 34039
48ImmunoglobulinsPhase 36394
49AntibodiesPhase 36394
50
TorcetrapibPhase 315262352-17-0159325
Synonyms:
(2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
262352-17-0
AC1L4LN3
CHEBI:49203
CHEBI:617982
CHEMBL479527
CID159325
CP 529414
CP-529,414
 
CP-529414
D06195
Ethyl (2R,4S)-4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
LS-187027
LS-187649
Torcetrapib
Torcetrapib (USAN/INN)
Torcetrapib [USAN]
ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate

Interventional clinical trials:

(show top 50)    (show all 65)
idNameStatusNCT IDPhase
1Comparison of High-Dose Rosuvastatin Versus Low Statin Dose Plus Fenofibrate Versus Low Statin Dose Plus Niacin in the Treatment of Mixed HyperlipidemiaUnknown statusNCT01010516Phase 4
2Study to Compare Welchol and TriCor to TriCor Alone in Patients With High CholesterolCompletedNCT00754039Phase 4
3Efficacy Study of Extended-Release Niacin/Lovastatin Versus Usual CareCompletedNCT00345657Phase 4
4Effect of Fenofibrate on Endothelial Function and High-density Lipoproteins (HDL)in Patients With Coronary Heart DiseaseCompletedNCT00552747Phase 4
5STITCH2 (Simplified Therapeutic Intervention to Control Hypertension and Hypercholesterolemia)CompletedNCT00637078Phase 4
6Open Label Study To Evaluate The Long-Term Safety Profiles Of Caduet In Japanese PatientsCompletedNCT01190007Phase 4
7Efficacy of Ezetimibe/Simvastatin 10/20 mg and MK0524A (1-2 g/Day) in Mixed Hyperlipidemia and Two or More Risk FactorsWithdrawnNCT00738985Phase 4
8Efficacy Study of Daily Pro-Omega LDL for Low-Density Lipoprotein Cholesterol and Triglyceride ReductionWithdrawnNCT02069106Phase 4
9Phase 3 Study to Evaluate the Efficacy and Safety of Omega-3-acids Ethylesters 90 in Type Ⅱb HyperlipidemiaUnknown statusNCT02035215Phase 3
10Efficacy and Safety of Fenofibrate Added on to Atorvastatin Compared With AtorvastatinUnknown statusNCT01956201Phase 3
11Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024)CompletedNCT00289900Phase 3
12A Study to Evaluate an Investigational Drug in Patients With Mixed Hyperlipidemia (0653A-071)(COMPLETED)CompletedNCT00093899Phase 3
13Study of Ezetimibe and Fenofibrate in Patients With Mixed Hyperlipidemia (0653-036)(COMPLETED)CompletedNCT00092573Phase 3
14Two Investigational Drugs in Patients With Mixed Hyperlipidemia (0653-036)CompletedNCT00092560Phase 3
15Lipid Efficacy Study (0524B-022)(COMPLETED)CompletedNCT00269217Phase 3
16Lipid Efficacy/Tolerability Study (0524A-020)CompletedNCT00269204Phase 3
17Effect of MK0524A on Cholesterol Levels (0524A-048)CompletedNCT00536510Phase 3
18Assess HDL-C Increase And Non-HDL Lowering Effect Of Torcetrapib/Atorvastatin Vs. FenofibrateCompletedNCT00139061Phase 3
19Comparison of the Combination of Fenofibrate and 40 mg Simvastatin Versus 40 mg Simvastatin MonotherapyCompletedNCT00352183Phase 3
20Comparison of the Combination of Fenofibrate and 20 mg Simvastatin Versus 40 mg Simvastatin MonotherapyCompletedNCT00349375Phase 3
21Tolerability of MK0524A Versus Niacin Extended-Release (0524A-054)CompletedNCT00378833Phase 3
22Comparison of the Combination of Fenofibrate and Simvastatin Versus AtorvastatinCompletedNCT00362934Phase 3
23Effect of an Investigational Compound on Tolerability of Extended Release Niacin (0524A-023)(COMPLETED)CompletedNCT00376584Phase 3
24Comparison of the Combination of Fenofibrate and Simvastatin Versus PravastatinCompletedNCT00362206Phase 3
25A Study to Evaluate the Lipid Regulating Effects of 1-Methylnicotinamide (1-MNA)CompletedNCT00519714Phase 2, Phase 3
26Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary CirrhosisCompletedNCT01654731Phase 3
27Study To Evaluate The Safety And Efficacy Of Torcetrapib/Atorvastatin In Subjects With Familial HypercholerolemiaCompletedNCT00134485Phase 3
28Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.CompletedNCT00136981Phase 3
29A Study to Evaluate Daily Pravastatin, Fenofibrate or Pravafen in the Treatment of Combined HyperlipidemiaCompletedNCT00459745Phase 3
30Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Patients With Genetic High Cholesterol DisorderCompletedNCT00134511Phase 3
31Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)CompletedNCT01730040Phase 3
32A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384)CompletedNCT02460159Phase 3
33Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578)CompletedNCT00552097Phase 3
34Carotid B-mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrapib/Atorvastatin to Atorvastatin.TerminatedNCT00134238Phase 3
35Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Subjects With A Genetic Cholesterol Disorder.TerminatedNCT00145431Phase 3
36Phase 2 Dose-Ranging Efficacy and Safety Trial of SCH 900271 in Participants With Primary Hypercholesterolemia or Mixed Hyperlipidemia (P05675)CompletedNCT00941603Phase 2
37A Pilot Study to Evaluate the Lipid Effects of TRIA-662CompletedNCT02008084Phase 2
38Efficacy of a New Symbiotic Formulation in Children With Familial HypercholesterolemiaCompletedNCT02048410Phase 1, Phase 2
39Trial of Antroquinonol in Patients With Hypercholesterolemia and HyperlipidemiaRecruitingNCT02719028Phase 2
40MK0859 Dose-Ranging Study (0859-003)TerminatedNCT00325455Phase 2
41A Study of MK0859 in Patients With Primary Hypercholesterolemia or Mixed Hyperlipidemia (MK-0859-011)(COMPLETED)CompletedNCT00565292Phase 1
42A Study to Evaluate the Effects of Laropiprant on the Antiplatelet Effects of Clopidogrel and Aspirin in Combination (MK-0524A-114)(COMPLETED)CompletedNCT01012219Phase 1
43The Effects of a Mediterranean Diet in Pediatric HyperlipidemiaCompletedNCT01308710Phase 1
44A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158)TerminatedNCT01583647Phase 1
45Comparison of the Efficacy and Safety of AtorVastatin mOnotherapy vs. Combination Atorvastatin/Fenofibric AcidUnknown statusNCT01974297
46Effectiveness of a Combined Strategy to Improve Therapeutic Compliance and Degree of Control Among Patients With HypercholesterolaemiaUnknown statusNCT02314663
47Simvastatin in Patients With Isolated Arterial HypertensionUnknown statusNCT01017835
48Evaluation of Chylomicrons Metabolism in Sub-Clinical Atherosclerosis in Patients Whit Heterozigous Familial Hypercholesterolemia (FH) Treated With Statin Plus EzetimibeUnknown statusNCT00475826
49Understanding the Genetic Basis of Familial Combined Hyperlipidemia in Mexican IndividualsCompletedNCT00365235
50Human Lipoprotein Pathophysiology - Subproject: Genetics of Familial Combined HyperlipidemiaCompletedNCT00005313

Search NIH Clinical Center for Hyperlipidemia, Familial Combined


Cochrane evidence based reviews: hyperlipidemia, familial combined

Genetic Tests for Hyperlipidemia, Familial Combined

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Genetic tests related to Hyperlipidemia, Familial Combined:

id Genetic test Affiliating Genes
1 Hyperlipidemia, Familial Combined27
2 Hyperlipidemia, Combined, 127
3 Hyperlipidemia Combined 124 USF1

Anatomical Context for Hyperlipidemia, Familial Combined

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MalaCards organs/tissues related to Hyperlipidemia, Familial Combined:

36
Heart

Publications for Hyperlipidemia, Familial Combined

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Variations for Hyperlipidemia, Familial Combined

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Clinvar genetic disease variations for Hyperlipidemia, Familial Combined:

5
id Gene Variation Type Significance SNP ID Assembly Location
1LPLLPL, -39T-CSNVPathogenic
2LPLNM_ 000237.2(LPL): c.953A> G (p.Asn318Ser)SNVPathogenicrs268GRCh37Chr 8, 19813529: 19813529
3LPLNM_ 000237.2(LPL): c.106G> A (p.Asp36Asn)SNVrisk factorrs1801177GRCh37Chr 8, 19805708: 19805708
4LPLLPL, -93T-GSNVPathogenic
5LPLNM_ 000237.2(LPL): c.904T> C (p.Cys302Arg)SNVLikely pathogenicGRCh38Chr 8, 19955969: 19955969

Expression for genes affiliated with Hyperlipidemia, Familial Combined

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Search GEO for disease gene expression data for Hyperlipidemia, Familial Combined.

Pathways for genes affiliated with Hyperlipidemia, Familial Combined

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Pathways related to Hyperlipidemia, Familial Combined according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
19.9APOA1, APOB
29.7APOA1, APOA2
3
Show member pathways
9.6APOA1, APOB, APOE
49.5APOA1, APOA5, APOE
59.4LIPC, LIPE
69.4HMGCR, INS, LPL
7
Show member pathways
9.3HMGCR, INS, LIPE
8
Show member pathways
9.2LIPC, LIPE, LPL
9
Show member pathways
9.2LIPC, LIPE, LPL
10
Show member pathways
9.1APOA1, APOB, APOE, INS
118.9APOA1, APOA2, APOA5, APOC3
128.8INS, LIPE, LPL, RXRG
13
Show member pathways
8.8APOA1, APOA2, APOA5, HMGCR, LPL
14
Show member pathways
8.5APOA1, APOA2, APOB, APOC3, APOE, LPL
15
Show member pathways
8.5APOA1, APOA2, APOB, APOC3, APOE, LPL
168.2APOA1, APOA2, APOA5, APOC3, LPL, RXRG
17
Show member pathways
7.2APOA1, APOA2, APOA5, APOB, APOC3, APOE
18
Show member pathways
7.1APOA1, APOA2, APOA5, APOB, APOC3, APOE
19
Show member pathways
6.3APOA1, APOA2, APOA5, APOB, APOC3, APOE

GO Terms for genes affiliated with Hyperlipidemia, Familial Combined

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Cellular components related to Hyperlipidemia, Familial Combined according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:003190410.5APOB, INS
2endocytic vesicle lumenGO:007168210.4APOA1, APOB, APOE
3blood microparticleGO:00725629.7APOA1, APOA2, APOA5, APOE
4intermediate-density lipoprotein particleGO:00343639.7APOA1, APOB, APOC3, APOE
5spherical high-density lipoprotein particleGO:00343669.7APOA1, APOA2, APOC3
6low-density lipoprotein particleGO:00343629.6APOA1, APOA5, APOB, APOE
7early endosomeGO:00057699.5APOA1, APOA2, APOB, APOC3, APOE
8chylomicronGO:00426278.9APOA1, APOA2, APOA5, APOB, APOC3, APOE
9high-density lipoprotein particleGO:00343648.8APOA1, APOA2, APOA5, APOE, LIPC
10endoplasmic reticulum lumenGO:00057888.3APOA1, APOA2, APOA5, APOB, APOE, INS
11very-low-density lipoprotein particleGO:00343618.1APOA1, APOA2, APOA5, APOB, APOC3, APOE
12extracellular regionGO:00055767.7APOA1, APOA2, APOA5, APOB, APOC3, APOE
13extracellular spaceGO:00056157.4APOA1, APOA2, APOA5, APOB, APOC3, APOE

Biological processes related to Hyperlipidemia, Familial Combined according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cholesterol storageGO:001088610.7APOB, LPL
2positive regulation of macrophage derived foam cell differentiationGO:001074410.7APOB, LPL
3lipid homeostasisGO:005508810.7APOE, USF1
4artery morphogenesisGO:004884410.7APOB, APOE
5lipoprotein catabolic processGO:004215910.6APOB, APOE
6positive regulation of fatty acid biosynthetic processGO:004572310.6APOA1, APOA5
7positive regulation of lipoprotein lipase activityGO:005100610.6APOA1, APOA5
8positive regulation of triglyceride catabolic processGO:001089810.6APOA1, APOA5
9negative regulation of vasodilationGO:004590810.4HMGCR, INS
10negative regulation of cytokine secretion involved in immune responseGO:000274010.4APOA1, APOA2
11negative regulation of lipase activityGO:006019210.4APOA1, APOA2
12peptidyl-methionine modificationGO:001820610.4APOA1, APOA2
13fatty acid homeostasisGO:005508910.4APOE, INS
14protein oxidationGO:001815810.4APOA1, APOA2
15positive regulation of lipid biosynthetic processGO:004688910.4APOE, INS
16positive regulation of nitric-oxide synthase activityGO:005100010.4APOE, INS
17negative regulation of cholesterol importGO:006062110.4APOA2, APOC3
18regulation of lipoprotein lipase activityGO:005100410.4LIPC, LPL
19positive regulation of lipid catabolic processGO:005099610.3APOA2, APOA5
20diacylglycerol catabolic processGO:004634010.3APOA2, LIPE
21cholesterol biosynthetic processGO:000669510.3APOA1, APOA5, HMGCR
22regulation of Cdc42 protein signal transductionGO:003248910.3APOA1, APOC3, APOE
23neuron projection regenerationGO:003110210.2APOA1, APOA5, APOE
24very-low-density lipoprotein particle assemblyGO:003437910.1APOB, APOC3
25high-density lipoprotein particle clearanceGO:003438410.1APOA1, APOA2, APOE
26negative regulation of very-low-density lipoprotein particle remodelingGO:001090310.1APOA1, APOA2, APOC3
27very-low-density lipoprotein particle clearanceGO:003444710.1APOB, APOE
28regulation of intestinal cholesterol absorptionGO:003030010.0APOA1, APOA2, APOA5
29triglyceride-rich lipoprotein particle remodelingGO:00343709.9APOA2, APOA5
30negative regulation of lipid catabolic processGO:00509959.8APOA2, APOC3, INS
31lipoprotein biosynthetic processGO:00421589.8APOA1, APOA2, APOB, APOE
32regulation of lipid metabolic processGO:00192169.7APOA1, APOA2, APOA5, HMGCR
33high-density lipoprotein particle assemblyGO:00343809.7APOA1, APOA2, APOA5, APOE
34positive regulation of cholesterol esterificationGO:00108739.7APOA1, APOA2, APOA5, APOE
35chylomicron remnant clearanceGO:00343829.7APOB, APOC3, APOE, LIPC
36steroid metabolic processGO:00082029.6APOA1, APOB, APOE, HMGCR, LIPE
37cholesterol transportGO:00303019.5APOA1, APOA2, APOB, LIPC
38low-density lipoprotein particle remodelingGO:00343749.5APOA2, APOB, APOE, LIPC
39chylomicron assemblyGO:00343789.5APOA1, APOA2, APOB, APOC3, APOE
40post-translational protein modificationGO:00436879.4APOA1, APOA2, APOA5, APOB, APOE
41phospholipid effluxGO:00337009.4APOA1, APOA2, APOA5, APOC3, APOE
42lipid catabolic processGO:00160429.4APOB, APOC3, LIPC, LIPE, LPL
43very-low-density lipoprotein particle remodelingGO:00343729.3APOE, LIPC, LPL
44chylomicron remodelingGO:00343719.3APOA1, APOA2, APOB, APOC3, APOE, LPL
45retinoid metabolic processGO:00015239.2APOA1, APOA2, APOB, APOC3, APOE, LPL
46high-density lipoprotein particle remodelingGO:00343759.1APOA1, APOA2, APOC3, APOE, LIPC
47cholesterol effluxGO:00333449.1APOA1, APOA2, APOA5, APOB, APOC3, APOE
48lipid transportGO:00068699.1APOA1, APOA2, APOA5, APOB, APOC3, APOE
49triglyceride metabolic processGO:00066419.1APOA2, APOA5, APOC3, APOE, LPL
50cellular protein metabolic processGO:00442678.9APOA1, APOA2, APOA5, APOB, APOE, INS

Molecular functions related to Hyperlipidemia, Familial Combined according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1lipase bindingGO:003547310.5APOA5, APOB
2lipoprotein particle bindingGO:007181310.4APOA1, APOE
3apolipoprotein receptor bindingGO:003419010.3APOA1, APOA2
4high-density lipoprotein particle bindingGO:000803510.3APOA1, APOA2
5apolipoprotein bindingGO:003418510.3LIPC, LPL
6phospholipase activityGO:000462010.1LIPC, LPL
7lipase activityGO:001629810.1LIPC, LIPE
8low-density lipoprotein particle receptor bindingGO:005075010.1APOA5, APOB, APOE
9high-density lipoprotein particle receptor bindingGO:007065310.0APOA1, APOA2, APOC3
10lipase inhibitor activityGO:005510210.0APOA1, APOA2, APOC3
11phosphatidylcholine bindingGO:00312109.8APOA1, APOA2, APOA5
12lipid transporter activityGO:00053199.6APOA1, APOA2, APOB, APOE
13phosphatidylcholine-sterol O-acyltransferase activator activityGO:00602289.5APOA1, APOA2, APOA5, APOE
14cholesterol transporter activityGO:00171279.4APOA1, APOA2, APOA5, APOB, APOE
15heparin bindingGO:00082019.3APOA5, APOB, APOE, LIPC, LPL
16cholesterol bindingGO:00154859.3APOA1, APOA2, APOA5, APOC3, APOE
17triglyceride lipase activityGO:00048069.2LIPC, LIPE, LPL
18lipid bindingGO:00082898.9APOA1, APOA2, APOA5, APOB, APOC3, APOE
19phospholipid bindingGO:00055438.7APOA1, APOA2, APOA5, APOB, APOC3, APOE

Sources for Hyperlipidemia, Familial Combined

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet