MCID: HYP011
MIFTS: 47

Hyperlipoproteinemia Type Iii malady

Genetic diseases category

Summaries for Hyperlipoproteinemia Type Iii

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MalaCards: Hyperlipoproteinemia Type Iii, also known as familial type 3 hyperlipoproteinemia, is related to hyperlipidemia type 3 and hyperlipoproteinemia type v. An important gene associated with Hyperlipoproteinemia Type Iii is APOA5 (apolipoprotein A-V), and among its related pathways are SREBF and miR33 in cholesterol and lipid homeostasis and A-beta Uptake & Degradation. The compounds alpha tocopherol and palmitate have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Hyperlipoproteinemia Type Iii

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8Disease Ontology, 60UMLS, 22GTR, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

hyperlipoproteinemia type iii 8 60
familial type 3 hyperlipoproteinemia 8 22
familial hypercholesterolaemia with hyperlipaemia 8
carbohydrate induced hyperlipemia 8
remnant hyperlipidemia 8


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Disease Ontology8 DOID:3145
NCIt39 C34710
SNOMED-CT56 42569002, 398796005
MeSH34 D006952

Related Diseases for Hyperlipoproteinemia Type Iii

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17GeneCards, 18GeneDecks
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Diseases in the Hyperlipoproteinemia Type V family:

hyperlipoproteinemia type iii Hyperlipoproteinemia Type Iv
Hyperlipoproteinemia Type 2 Hyperlipoproteinemia, Type Ib

Diseases related to Hyperlipoproteinemia Type Iii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1hyperlipidemia type 330.6COG2, APOA1, APOE, APOA5, LDLR, CETP
2hyperlipoproteinemia type v30.3LPL, APOE
3hyperlipoproteinemia type iv10.2
4ischemic heart disease10.0LPL
5lipoprotein lipase deficiency10.0LPL
6acromegaly10.0LPA
7hepatitis10.0LDLR
8ischemia10.0HMGCR
9psoriasis10.0LDLR
10thromboembolism10.0APOA1
11hyperthyroidism10.0LDLR
12schizophrenia10.0LDLR
13pancreatitis10.0LPL
14smith-lemli-opitz syndrome10.0HMGCR
15myositis10.0HMGCR
16breast cancer10.0LDLR
17abdominal aortic aneurysm10.0APOE
18lipoprotein glomerulopathy10.0APOE
19chylomicron retention disease10.0APOB
20hyperuricemia10.0APOB
21cerebral atherosclerosis10.0APOA1
22sitosterolemia10.0HMGCR
23colorectal cancer10.0LDLR, LPL
24arthritis10.0HMGCR
25complete lcat deficiency10.0LPA, APOA1
26familial hypertriglyceridemia10.0LPL, APOB
27cholestasis10.0CETP, LIPC
28alcohol abuse10.0COG2
29polycystic ovary syndrome10.0LIPC, APOA1
30hyperhomocysteinemia10.0LPA, APOE
31lipase deficiency combined10.0LPL, LIPC
32hepatocellular carcinoma10.0LIPC, LDLR
33arcus senilis10.0APOA1, APOB
34hyperinsulinism10.0APOB, LPL
35amyloidosis, secondary10.0APOA1, LPA
36hepatitis c10.0LDLR, HMGCR, LPL
37hypothyroidism10.0CETP, LPA, APOB
38stroke, hemorrhagic10.0APOE, HMGCR
39age related macular degeneration10.0APOE, APOB
40venous thrombosis10.0CETP, HMGCR, APOB
41alzheimer disease type 210.0APOE, CETP
42vascular dementia10.0APOE, LPA
43retinal disease10.0CETP, LPL, LPA
44uremia10.0LPA, LPL, LIPC, LDLR
45dementia10.0APOE, LPA, LPL, CETP
46familial hypercholesterolemia10.0APOB, HMGCR, CETP, LDLR
47lipodystrophy10.0LDLR, HMGCR, LPL, APOB
48acute myocardial infarction10.0APOB, APOA1, HMGCR, LPA
49aortic disease10.0APOE, LDLR
50glucose intolerance10.0COG2, APOB, LPL

Graphical network of the top 20 diseases related to Hyperlipoproteinemia Type Iii:



Diseases related to hyperlipoproteinemia type iii

Clinical Features for Hyperlipoproteinemia Type Iii

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Drugs & Therapeutics for Hyperlipoproteinemia Type Iii

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Hyperlipoproteinemia Type Iii

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22GTR
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Genetic tests related to Hyperlipoproteinemia Type Iii:

id Genetic test Affiliating Genes
1 Familial Type 3 Hyperlipoproteinemia22

Anatomical Context for Hyperlipoproteinemia Type Iii

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Animal Models for Hyperlipoproteinemia Type Iii or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperlipoproteinemia Type Iii:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.6LDLR, LPL, APOB, APOE, APOA1
2MP:00053767.1APOE, APOA5, APOB, LPL, LIPC, LDLR

Publications for Hyperlipoproteinemia Type Iii

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50PubMed
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Articles related to Hyperlipoproteinemia Type Iii:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4. (20861163)
2011
2
Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia. (22069485)
2011
3
Disappearance of angina pectoris by lipid-lowering in type III hyperlipoproteinemia. (21247547)
2011
4
Severe hypertriglyceridemia and recurrent pancreatitis in a girl with type Ia glycogen storage disease and type III hyperlipoproteinemia. (19842193)
2009
5
The expression of type III hyperlipoproteinemia: involvement of lipolysis genes. (19034316)
2009
6
Lipoprotein glomerulopathy-like disease in a patient with type III hyperlipoproteinemia due to apolipoprotein E2 (Arg158 Cys)/3 heterozygosity. (17593519)
2007
7
Type III hyperlipoproteinemia with xanthomas and multiple myeloma. (16227109)
2005
8
Detailed analysis of serum lipids and lipoproteins from Japanese type III hyperlipoproteinemia with apolipoprotein E2/2 phenotype. (15369733)
2004
9
Apolipoprotein epsilon 2/3 genotype and type III hyperlipoproteinemia among Taiwanese. (12636937)
2003
10
Study on lipoprotein lipase gene Hind III polymorphism in Chinese type IIb hyperlipoproteinemia]. (14669227)
2003
11
Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype. (12924933)
2003
12
ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice. (12235184)
2002
13
Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia. (11834531)
2002
14
Doubling expression of the low density lipoprotein receptor by truncation of the 3'-untranslated region sequence ameliorates type iii hyperlipoproteinemia in mice expressing the human apoe2 isoform. (11076954)
2001
15
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. (10552997)
1999
16
Apolipoprotein E2 (Arg136 --> Cys) mutation in the receptor binding domain of apoE is not associated with dominant type III hyperlipoproteinemia. (9548597)
1998
17
Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. (9649566)
1998
18
Abnormalities of apolipoprotein E (type III hyperlipoproteinemia)]. (9645005)
1998
19
Expression of type III hyperlipoproteinemia in patients homozygous for apolipoprotein E-2 is modulated by lipoprotein lipase and postprandial hyperinsulinemia. (9587070)
1998
20
The apolipoprotein E2 (Arg145Cys) mutation causes autosomal dominant type III hyperlipoproteinemia with incomplete penetrance. (9157949)
1997
21
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. (9409260)
1997
22
Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer's disease. (8682647)
1996
23
Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. (8756331)
1996
24
Apolipoprotein E isoforms and rare mutations: parallel reduction in binding to cells and to heparin reflects severity of associated type III hyperlipoproteinemia. (7775863)
1995
25
Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu). (7635945)
1995
26
Co-expression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters plasma cholesterol distribution. Implications for the pathogenesis of type III hyperlipoproteinemia. (7798236)
1994
27
Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia. (8175773)
1994
28
A new approach for the detection of type III hyperlipoproteinemia by RLP-cholesterol assay. (9222866)
1994
29
Relation of cardiovascular risk factors to atherosclerosis in type III hyperlipoproteinemia. (8370576)
1993
30
Apolipoprotein E phenotyping--useful in the study of hyperlipoproteinemia type III]. (8480294)
1993
31
Apolipoprotein E1 Lys-146----Glu with type III hyperlipoproteinemia. (1356443)
1992
32
The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia. (1730728)
1992
33
Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. No evidence for a triglyceride-rich precursor of lipoprotein(a). (1430218)
1992
34
Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype. (1360898)
1992
35
Familial apolipoprotein E deficiency and type III hyperlipoproteinemia due to a premature stop codon in the apolipoprotein E gene. (1361196)
1992
36
Type III hyperlipoproteinemia in monoclonal IgM gammopathy]. (1935653)
1991
37
Apolipoprotein E-4 Philadelphia (Glu-13-->Lys,Arg-145-->Cys). Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia. (1674745)
1991
38
Apolipoprotein E allele frequencies in non-insulin-dependent diabetes mellitus with hypertriglyceridemia (type IIb, III, IV, and V hyperlipoproteinemia). (1861626)
1991
39
Cholesterol accumulation in J774 macrophages induced by triglyceride-rich lipoproteins. Comparison of very low density lipoprotein from subjects with type III, IV, and V hyperlipoproteinemias. (1998641)
1991
40
Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1). (1973700)
1990
41
Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant. (2539388)
1989
42
Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia. (2892779)
1988
43
Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia. (3038959)
1987
44
Serum and interstitial fluid apolipoprotein E levels in the healthy and in hyperlipoproteinemia type III as studied by radioimmunoassay. (4042371)
1985
45
New mutants of apolipoprotein E associated with atherosclerotic diseases but not to type III hyperlipoproteinemia. (6480826)
1984
46
Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. (7175379)
1982
47
Apolipoprotein E (role in lipoprotein metabolism and pathophysiology of hyperlipoproteinemia type III). (6283616)
1982
48
Polymorphism of apolipoprotein E. II. Genetics of hyperlipoproteinemia type III. (215360)
1979
49
Polymorphism of apolipoprotein E. I. Methodological aspects and diagnosis of hyperlipoproteinemia type III without ultracentrifugation. (215358)
1978
50
Familial hyperlipoproteinemia type III: deficiency of a specific apolipoprotein (apo E-III) in the very-low-density lipoproteins. (169165)
1975

Genetic Variations for Hyperlipoproteinemia Type Iii

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Expression for genes affiliated with Hyperlipoproteinemia Type Iii

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperlipoproteinemia Type Iii

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Pathways for genes affiliated with Hyperlipoproteinemia Type Iii

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37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 12EMD Millipore, 53Reactome, 49PharmGKB
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Pathways related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7HMGCR, LDLR
29.5LDLR, APOE
39.4LPL, APOA5, APOA1
49.4CETP, APOB
59.4CETP, APOB
6
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9.3LPL, HMGCR, LDLR
7
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9.3HMGCR, APOA5, APOA1
89.2APOB, APOA1
99.2APOB, APOA1
108.9APOA1, APOB, LPA
118.8LDLR, APOB, APOA1
128.7APOB, LPA, CETP, LDLR
13
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8.6APOA1, APOE, APOB
148.6APOA1, APOE, APOB
157.9LDLR, LPL, APOB, APOE, APOA1
16
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7.9LDLR, LPL, APOB, APOE, APOA1
17
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7.2APOA1, APOE, APOB, LPA, LPL, CETP
18
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7.1LIPC, LPL, LPA, APOB, APOA5, APOE
19
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6.3LDLR, APOA1, APOE, APOA5, APOB, LPL

Compounds for genes affiliated with Hyperlipoproteinemia Type Iii

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4410.1LPL, LDLR
2palmitate449.6CETP, COG2, LDLR
3xbai449.5LDLR, LPL, APOE
4sele448.9APOE, CETP, LDLR, LPL
5psyllium448.9LDLR, CETP, HMGCR, APOB
6dimyristoylphosphatidylcholine448.8APOE, LDLR, APOA5, APOA1, LPA
7fenofibric acid44 289.6HMGCR, LPL, APOB, APOA1
8colestipol448.6HMGCR, APOB, APOA1, COG2
9atenolol44 28 49 11 2412.5LDLR, COG2, APOA1, APOE
10acipimox44 289.5HMGCR, CETP, APOA1, APOB
11mspi448.4LDLR, LPA, APOB, CETP, APOA1
12ciprofibrate44 289.4HMGCR, LPL, APOA1, APOB, LDLR
13campesterol44 249.4APOA1, APOB, APOE, HMGCR
14tocopherol448.3HMGCR, LDLR, LPL, APOA1, APOB
15dextran sulfate448.3CETP, LDLR, APOA1, LPL, APOB
16lathosterol44 249.3CETP, APOB, APOE, HMGCR, LDLR
17stearic acid44 11 2410.1CETP, LIPC, LDLR, LPL, COG2
18oleic acid44 28 11 2411.1LIPC, LDLR, CETP, LPA, LPL, APOB
19retinyl palmitate44 249.1APOB, COG2, APOA1, LPL, APOE
20ezetimibe44 119.0LDLR, CETP, COG2, HMGCR, APOB, APOA1
21rosuvastatin44 49 28 1111.0LDLR, COG2, APOA1, CETP, APOB, HMGCR
22intralipid447.8APOA1, APOE, APOB, LPL, LIPC, CETP
23heparin44 28 11 2410.8LIPC, LDLR, CETP, HMGCR, LPL, COG2
24pioglitazone44 49 28 1110.7COG2, LIPC, APOA1, APOB, LPL
25homocysteine44 248.7APOB, CETP, LPA, APOE, APOA1, COG2
26cholestyramine447.5COG2, APOE, APOB, LPA, HMGCR, CETP
27cyclosporin a44 28 599.4COG2, APOE, LIPC, HMGCR, LDLR, CETP
28niacin44 118.4LPA, LPL, HMGCR, CETP, LDLR, COG2
29fatty acid447.3CETP, APOA5, LPA, COG2, LDLR, LPL
30phosphatidylcholine447.1APOA1, LPL, LIPC, CETP, LDLR, LPA
31vitamin a44 11 249.1LPA, APOB, APOE, LIPC, APOA1, LDLR
32pravastatin44 49 28 11 2411.1APOA1, APOE, APOB, LPA, HMGCR, CETP
33fluvastatin44 49 28 1110.1APOA1, APOE, APOB, LPL, HMGCR, CETP
34probucol44 118.1APOA1, APOE, APOB, LPL, LIPC, HMGCR
35aspirin44 49 28 2410.0APOA1, APOE, LPA, HMGCR, CETP, LDLR
36phospholipid446.9COG2, CETP, LIPC, LPL, APOB, APOE
37sterol446.8LDLR, CETP, LIPC, APOB, HMGCR, APOE
38simvastatin44 49 59 28 11 2411.8LPA, LPL, HMGCR, CETP, LDLR, APOB
39testosterone44 59 11 249.7LIPC, COG2, APOA1, APOE, APOB, LPL
40triacylglycerol446.7COG2, APOA1, APOE, APOA5, APOB, LPL
41fenofibrate44 49 118.6COG2, APOA1, APOA5, APOB, LPA, LPL
42estrogen446.4LIPC, CETP, COG2, LDLR, LPL, LPA
43atorvastatin44 49 28 11 2410.2COG2, APOA1, APOE, APOB, LPA, LPL
44bezafibrate44 28 118.2LIPC, HMGCR, CETP, LDLR, LPL, LPA
45gemfibrozil44 28 118.2LDLR, COG2, APOA1, APOE, APOB, LPL
46lovastatin44 49 59 28 1110.2LDLR, CETP, HMGCR, COG2, APOA1, APOE
47cholesterol ester446.2COG2, APOA1, APOE, APOB, LPA, LPL
48thyroxine44 247.2LPA, APOB, APOE, APOA1, COG2, LIPC
49cholesterol44 28 11 248.9LPL, LPA, APOB, APOE, APOA1, COG2
50lipid445.9LIPC, CETP, APOA1, APOE, APOA5, APOB

GO Terms for genes affiliated with Hyperlipoproteinemia Type Iii

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16Gene Ontology
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Cellular components related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:0306699.3LDLR, APOB
2intermediate-density lipoprotein particleGO:0343638.7APOB, APOE
3endocytic vesicle lumenGO:0716828.6APOB, APOE, APOA1
4chylomicronGO:0426278.6APOE, APOA5, APOB, LPL
5low-density lipoprotein particleGO:0343628.5LDLR, APOB, APOA5, APOE
6high-density lipoprotein particleGO:0343648.5APOA1, APOE, APOA5, LIPC, CETP
7early endosomeGO:0057698.2APOA1, APOE, APOB, LDLR
8very-low-density lipoprotein particleGO:0343618.2LPL, APOB, APOA5, APOE, APOA1
9extracellular spaceGO:0056157.2APOA1, APOE, APOA5, APOB, LPL, LIPC
10extracellular regionGO:0055767.2APOA1, APOE, APOA5, APOB, LPA, LPL

Biological processes related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1phospholipid transportGO:01591410.0CETP, LDLR
2cholesterol importGO:07050810.0LDLR, APOA1
3lipid transportGO:0068699.9CETP, LPA, APOA5
4phospholipid homeostasisGO:0550919.9CETP, APOA1
5regulation of Cdc42 protein signal transductionGO:0324899.7APOA1, APOE
6peripheral nervous system axon regenerationGO:0140129.7APOE, APOA1
7high-density lipoprotein particle assemblyGO:0343809.7APOE, APOA1
8high-density lipoprotein particle clearanceGO:0343849.7APOA1, APOE
9positive regulation of cholesterol esterificationGO:0108739.6APOE, APOA1
10cholesterol biosynthetic processGO:0066959.6HMGCR, APOA1
11chylomicron remnant clearanceGO:0343829.6APOE, LIPC
12positive regulation of cholesterol storageGO:0108869.5LPL, APOB
13phospholipid effluxGO:0337009.5APOE, APOA1
14low-density lipoprotein particle clearanceGO:0343839.5APOB, LDLR
15positive regulation of macrophage derived foam cell differentiationGO:0107449.4LPL, APOB
16cellular lipid metabolic processGO:0442559.3APOA1, APOA5, HMGCR
17triglyceride metabolic processGO:0066419.3APOE, APOA5, LPL, CETP
18negative regulation of MAP kinase activityGO:0434079.1HMGCR, APOE
19very-low-density lipoprotein particle remodelingGO:0343729.1CETP, LIPC, LPL, APOE
20lipoprotein catabolic processGO:0421599.0LDLR, APOB, APOE
21triglyceride homeostasisGO:0703289.0APOA1, APOA5, LPL, LIPC, CETP
22high-density lipoprotein particle remodelingGO:0343759.0APOA1, APOE, LIPC, CETP
23reverse cholesterol transportGO:0436918.9APOA1, APOE, LIPC, CETP
24artery morphogenesisGO:0488448.9APOB, APOE
25lipoprotein biosynthetic processGO:0421588.9APOB, APOE, APOA1
26cholesterol effluxGO:0333448.9APOA1, APOE, APOB
27cholesterol transportGO:0303018.9APOA1, APOB, CETP, LDLR
28triglyceride catabolic processGO:0194338.9APOA5, APOB, LPL, LIPC
29low-density lipoprotein particle remodelingGO:0343748.6APOE, APOB, LIPC, CETP
30receptor-mediated endocytosisGO:0068988.4LDLR, CETP, LPA, APOB, APOE
31retinoid metabolic processGO:0015238.2APOA1, APOE, APOB, LPL, LDLR
32phototransduction, visible lightGO:0076038.2LDLR, LPL, APOB, APOE, APOA1
33cholesterol metabolic processGO:0082037.8APOA1, APOE, APOB, LIPC, CETP, LDLR
34cholesterol homeostasisGO:0426327.5APOA1, APOE, APOA5, APOB, LIPC, CETP
35lipoprotein metabolic processGO:0421577.4LDLR, APOA1, CETP, LPL, LPA, APOB
36small molecule metabolic processGO:0442816.9APOA1, APOE, APOA5, APOB, LPA, LPL

Molecular functions related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1triglyceride bindingGO:01712910.1CETP, LPL
2phosphatidylcholine bindingGO:03121010.1APOA5, CETP
3phospholipid transporter activityGO:00554810.0CETP, APOA1
4phospholipase activityGO:0046209.8LIPC, LPL
5low-density lipoprotein particle bindingGO:0301699.7LIPC, LDLR
6phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.7APOA1, APOE
7lipid transporter activityGO:0053199.6APOE, CETP
8triglyceride lipase activityGO:0048069.6LIPC, LPL
9apolipoprotein bindingGO:0341859.6LIPC, LPL, LPA
10cholesterol bindingGO:0154859.4CETP, APOA1
11lipid bindingGO:0082899.4CETP, APOA5, APOE
12beta-amyloid bindingGO:0015409.3APOA1, APOE
13low-density lipoprotein particle receptor bindingGO:0507509.0APOE, APOA5, APOB
14enzyme bindingGO:0198998.9APOB, APOA5, APOA1
15cholesterol transporter activityGO:0171278.6CETP, APOB, APOE, APOA1
16phospholipid bindingGO:0055438.5APOA1, APOE, APOA5, APOB
17heparin bindingGO:0082017.9LIPC, APOE, APOA5, APOB, LPA, LPL

Products for genes affiliated with Hyperlipoproteinemia Type Iii

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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