MCID: HYP011
MIFTS: 42

Hyperlipoproteinemia Type Iii malady

Categories: Genetic diseases, Metabolic diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Hyperlipoproteinemia Type Iii

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Aliases & Descriptions for Hyperlipoproteinemia Type Iii:

Name: Hyperlipoproteinemia Type Iii 11 50 39 13 68
Familial Hypercholesterolaemia with Hyperlipaemia 11
Familial Type 3 Hyperlipoproteinemia 11
 
Familial Hyperlipoproteinemia Type 3 27
Carbohydrate Induced Hyperlipemia 11
Remnant Hyperlipidemia 11

Classifications:



External Ids:

Disease Ontology11 DOID:3145
MeSH39 D006952
SNOMED-CT62 398796005, 42569002
NCIt45 C34710

Summaries for Hyperlipoproteinemia Type Iii

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MalaCards based summary: Hyperlipoproteinemia Type Iii, also known as familial hypercholesterolaemia with hyperlipaemia, is related to hyperlipidemia type 3 and hyperchylomicronemia, late-onset. An important gene associated with Hyperlipoproteinemia Type Iii is APOE (Apolipoprotein E), and among its related pathways are A-beta Pathways: Uptake and Degradation and Vitamin digestion and absorption. Related mouse phenotypes are Increased LDL uptake and Decreased free cholesterol.

Related Diseases for Hyperlipoproteinemia Type Iii

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Diseases in the Hyperlipoproteinemia Type Iv family:

Hyperlipoproteinemia, Type 1d Hyperlipoproteinemia, Type Ib
hyperlipoproteinemia type iii

Diseases related to Hyperlipoproteinemia Type Iii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1hyperlipidemia type 311.2
2hyperchylomicronemia, late-onset11.1
3hyperlipoproteinemia type iv11.1
4cardiovascular disease risk factor )10.9
5zap-70 deficiency10.3APOB, APOE
6alport syndrome and thin basement membrane nephropathy10.3APOE, LPL
7polycystic kidney disease, infantile severe, with tuberous sclerosis10.2LIPC, LPL
8keratoconus 410.2APOB, APOE, LDLR
9hypercholesterolemia, due to ligand-defective apo b10.2APOB, APOE, LDLR
10cetp-related hyperalphalipoproteinemia10.2APOB, APOE
11myxofibrosarcoma10.1APOE, LPL
12c1s deficiency10.1APOA5, APOE, LPL
13abducens nerve neoplasm10.1APOA5, LIPC, LPL
14familial progressive cardiac conduction defect10.1APOA1, APOE
15alzheimer disease 19, late onset10.1APOB, APOE, LDLR, LPA
16exudative vitreoretinopathy 2, x-linked10.1APOB, COG2
17asphyxia neonatorum10.1APOE, LDLR, LPA, LPL
18pars planitis10.1APOA1, APOE
19primary pigmented nodular adrenocortical disease10.0APOA1, APOB, APOE
20dyserythropoietic anemia, congenital, type ii10.0APOA1, APOE, LPA
21congenital chloride diarrhea10.0APOA1, APOB, LPA
22anaplastic ganglioglioma10.0APOA1, LPA
23albinism, oculocutaneous, type v10.0APOA1, APOB, APOE, LPA
24pontocerebellar hypoplasia, type 109.9APOE, HMGCR, LDLR
25joint disorders9.9APOA1, APOB, APOE, LPL
26camptodactyly-arthropathy-coxa vara-pericarditis syndrome9.9APOB, APOE, CETP, LIPC
27cervix small cell carcinoma9.9APOA1, APOB, APOE, LDLR
28hyperchlorhidrosis, isolated9.9APOA1, APOE, LIPC, LPL
29gait apraxia9.9APOA1, APOB, APOE, CETP
30craniodiaphyseal dysplasia9.9APOA1, APOB
31posterior uveal melanoma9.9APOA1, APOB, COG2
32dentinogenesis imperfecta type 29.9APOB, APOE, HMGCR, LDLR
33body dysmorphic disorder9.9APOA1, APOB, COG2
34fibrosarcoma of bone9.9APOB, HMGCR, LDLR, LPA
35bird fancier's lung9.8APOA1, APOB, APOE, LPA, LPL
36transient retinal arterial occlusion9.8APOA1, APOB, HMGCR
37neuropathy, hereditary sensory and autonomic, type ia9.8APOA1, APOB, APOE, CETP, LPA
38mannosidosis, beta9.8APOA1, APOB, APOE, CETP, LPL
39optic nerve neoplasm9.8APOA1, APOB, APOE, COG2, LPA
40spinocerebellar ataxia 209.7APOA1, APOB, HMGCR, LPA
41chondrocalcinosis with early-onset osteoarthritis9.7APOA1, APOB, APOE, CETP, LPA, LPL
42diabetes mellitus, insulin-dependent, 209.7APOA1, APOB, COG2, LPA, LPL
43budd-chiari syndrome9.7APOB, APOE, COG2, HMGCR, LPA
44severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome9.6APOB, APOE, HMGCR, LDLR, LIPC, LPL
45von willebrand disease, platelet-type9.6APOA1, APOB, APOE, CETP, LDLR, LPA
46cataract 5, multiple types9.5APOA1, APOB, APOE, CETP, LDLR, LIPC
47stone in bladder diverticulum9.5APOA1, APOB, APOE, CETP, COG2, LDLR
48myelophthisic anemia9.4APOA1, APOB, APOE, COG2, HMGCR, LPA
49hypertriglyceridemia9.4APOA1, APOB, APOE, CETP, LDLR, LIPC
50pericarditis9.4APOA1, APOB, APOE, HMGCR, LDLR, LPA

Graphical network of the top 20 diseases related to Hyperlipoproteinemia Type Iii:



Diseases related to hyperlipoproteinemia type iii

Symptoms & Phenotypes for Hyperlipoproteinemia Type Iii

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GenomeRNAi Phenotypes related to Hyperlipoproteinemia Type Iii according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00340-A-19.7APOA1, APOE, LDLR, LPL
2GR00340-A-27.3APOA1, APOA5, APOB, APOE, CETP, HMGCR

MGI Mouse Phenotypes related to Hyperlipoproteinemia Type Iii according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.9APOA1, APOB, APOE, HMGCR, LDLR, LPL
2MP:00053766.8APOA1, APOA5, APOB, APOE, COG2, HMGCR

Drugs & Therapeutics for Hyperlipoproteinemia Type Iii

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Drugs for Hyperlipoproteinemia Type Iii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Anticholesteremic AgentsPhase 4, Phase 32025
2Hypolipidemic AgentsPhase 4, Phase 32785
3Lipid Regulating AgentsPhase 4, Phase 32766
4AntimetabolitesPhase 4, Phase 312054
5Colesevelam HydrochloridePhase 448
6
EzetimibeapprovedPhase 3279163222-33-1150311
Synonyms:
(-)-Sch 58235
(1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone)
(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
(3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-(4-hydroxyphenyl)-2-azetidione
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone
163222-33-1
AC-1057
AC1L442L
C108606
CHEBI:49040
CHEMBL1138
CID150311
CPD000466334
D01966
DB00973
Essex brand of ezetimibe
Ezedoc
Ezetimiba
Ezetimibe
Ezetimibe (JAN/USAN/INN)
Ezetimibe [USAN:INN]
Ezetimibum
 
Ezetrol
HMS2051K16
LS-181801
MK-0653
MLS000759443
MLS001424125
MSD brand of ezetimibe
Merck brand of ezetimibe
MolPort-005-938-627
S1655_Selleck
SAM001246623
SCH-58235
SCH58235
SMR000466334
STK640490
STOCK6S-73750
Sch 58235
Schering-Plough brand of ezetimibe
UNII-EOR26LQQ24
ZINC03810860
Zetia
Zetia (TN)
Zetia , Ezetrol, Ezetimibe
Zient
ezetimib
7
FosamprenavirapprovedPhase 377226700-79-4131536
Synonyms:
((3S)Oxolan-3-yloxy)-N-((1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-benzyl-2-(phosphonooxy)propyl)carboxamide
(3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester
226700-79-4
AC1L2ZCO
Amprenavir phosphate
CHEMBL1664
CID131536
Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)-, C-((3S)-tetrahydro-3-furanyl) ester
D02497
DB01319
Fosamprenavir
Fosamprenavir (INN)
Fosamprenavir [INN]
 
GW 433908
GW433908
GW433908A (*Sodium Salt*)
GW433908G (*Calcium Salt*)
HSDB 7340
LS-187013
LS-187787
Lexiva
Lexiva (TM)
MolPort-005-943-058
Telzir
Telzir(TM)
VX 175
VX-175
[(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonooxybutan-2-yl]carbamate
8
FluvastatinapprovedPhase 35893957-54-11548972
Synonyms:
(+)-(3R,5S)-fluvastatin
(-)-(3S,5R)-fluvastatin
(3R,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5R,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
(3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3S,5R,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(Z,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoate
7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
93957-54-1
AC1L1FUW
AC1L3TXK
AC1L9J7I
AC1LU7LJ
AC1NS4EB
AC1OC9O5
AC1Q1PZO
BIDD:GT0839
BPBio1_000965
BRD-K03602135-236-02-1
BSPBio_000877
C07014
C24H26FNO4
CHEBI:38562
CHEBI:38565
CHEBI:38567
CHEBI:5136
CHEMBL1078
CHEMBL170417
CID10501876
CID146801
CID1548972
CID3403
 
CID446155
CID5353627
CID6914285
CID9887837
CPD001453708
Canef
Cranoc
D07983
DB01095
Fluindostatin
Fluvas
Fluvas (TN)
Fluvastatin & Primycin
Fluvastatin (INN)
Fluvastatin [INN:BAN]
Fluvastatina
Fluvastatina [INN-Spanish]
Fluvastatine
Fluvastatine [INN-French]
Fluvastatinum
Fluvastatinum [INN-Latin]
HMS2089P06
I06-2297
LS-7404
Lescol
Lescol XL
MolPort-003-847-470
Prestwick0_000859
Prestwick1_000859
Prestwick2_000859
Prestwick3_000859
SAM002548940
SPBio_002798
T6624179
TL8005940
UNII-4L066368AS
XU 62320
XU-62320
fluvastatin
fluvastatin sodium
fluvastatina
fluvastatine
fluvastatinum
nchembio.301-comp9
nchembio790-comp18
9
PitavastatinapprovedPhase 366147511-69-1, 147526-32-76366718, 5282452
Synonyms:
( )-(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoic acid
(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-7-(2-Cyclopropyl-4-(p-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoic acid
(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
111GE002
147511-69-1
147526-32-7
2C25H23FNO4.Ca
AC1NR03G
AC1NR03J
AKOS005145916
Alipza
Bis((3R,5S,6E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate), monocalcium salt
C13334
CCRIS 8652
CID5282451
CID5282452
D01862
Itavastatin
Itavastatin calcium
KS-1220
LS-190698
 
LS-74594
LS-74595
Livalo
Livalo (TN)
Livalo, Pitavastatin calcium
Livazo
MolPort-006-822-984
NK 104
NK-104
NKS-104
Nisvastatin
P 872441
P-872441
Pitavastatia
Pitavastatin
Pitavastatin [INN]
Pitavastatin calcium
Pitavastatin calcium (JAN)
Pitavastatin hemicalcium
Pitavastatine
Pitavastatinum
S1759_Selleck
ZINC01534965
calcium (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
10
PravastatinapprovedPhase 315081093-37-054687
Synonyms:
(+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid
(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha))-1-Naphthaleneheptanoic acid
3beta-Hydroxycompactin
81093-37-0
81131-70-6 (hydrochloride salt)
AC1L1HJL
AC1Q5T3M
BIDD:GT0773
BRD-K60511616-236-01-4
C01844
C23H36O7
CCRIS 7557
CHEMBL1144
CID54687
Compactin
D08410
DB00175
Elisor
Eptastatin
FT-0082682
KS-5015
LS-94713
Lipostat
Mevalothin
Mevalotin
Mevastatin
Mevinolin
 
Oliprevin
Pravachol
Pravaselect
Pravastatin (INN)
Pravastatin Sodium
Pravastatin Sodium Salt
Pravastatin [INN:BAN]
Pravastatin acid
Pravastatin sodium
Pravastatin tert-Octylamine Salt
Pravastatina
Pravastatina [Spanish]
Pravastatine
Pravastatine [French]
Pravastatinum
Pravastatinum [Latin]
Pravator
Pravator (TN)
RMS-431
SQ-31,000
Selectin
Selektine
Selipran
UNII-KXO2KT9N0G
Vasten
nchembio.301-comp7
nchembio790-comp15
pravastatin
pravastatina
pravastatine
pravastatinum
11
SimvastatinapprovedPhase 351979902-63-954454
Synonyms:
(+)-Simvastatin
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
79902-63-9
AC-1530
AC1L1H1F
AKOS005111006
ARONIS24119
BCBcMAP01_000007
BIDD:GT0769
BPBio1_001001
BRD-K22134346-001-05-8
BRN 4768037
BSPBio_000909
BSPBio_002337
Bio-0672
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
C25H38O5
CCRIS 7558
CHEBI:9150
CHEMBL1064
CID54454
CPD000718785
Cholestat
Coledis
Colemin
Corolin
D00434
D019821
DRG-0320
Denan
DivK1c_006991
Eucor
HMS1570N11
HMS1922H13
HMS2089D12
HMS2093E06
HSDB 7208
InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
KBio1_001935
KBio2_002197
KBio2_004765
KBio2_007333
KBio3_001557
KBioGR_001244
KBioSS_002197
KS-1113
Kolestevan
L 644128-000U
LS-46264
Labistatin
Lipex
Lipinorm
Liponorm
Lipovas
Lodales
MK 0733
MK 733
MK-0733
MK-733
MK733
MLS001304029
MLS001333077
MLS001333078
 
MLS002154038
Medipo
Modutrol
MolPort-002-507-345
MolPort-002-885-862
NCGC00017324-01
NCGC00017324-02
NCGC00017324-03
Nivelipol
Nor-Vastina
Pantok
Pepstatin
Prestwick0_000865
Prestwick1_000865
Prestwick2_000865
Prestwick3_000865
Prestwick_171
Rechol
Rendapid
S1792_Selleck
S6196_SIGMA
SAM002589969
SMR000718785
SPBio_001881
SPBio_002830
SPECTRUM1504236
STK801938
Simcor
Simovil
Simvast CR
Simvastatin
Simvastatin & Primycin
Simvastatin (JAN/USP/INN)
Simvastatin [USAN:INN:BAN]
Simvastatin [Usan:Ban:Inn]
Simvastatin lactone
Simvastatin, Compactin
Simvastatina
Simvastatina [Spanish]
Simvastatine
Simvastatine [French]
Simvastatinum
Simvastatinum [Latin]
Simvotin
Sinvacor
Sinvascor
Sivastin
SpecPlus_000895
Spectrum2_001671
Spectrum3_000669
Spectrum4_000632
Spectrum5_001428
Spectrum_001717
Statin
Synvinolin
TNP00259
UNII-AGG2FN16EV
Valemia
Vasotenal
Velostatin
Vytorin
ZINC03780893
Zocor
Zocor (TN)
Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin
Zocord
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta
nchembio790-comp16
simvastatin
12
FenofibrateapprovedPhase 317049562-28-93339
Synonyms:
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
49562-28-9
AB00052196
AC-4227
AC1L1FPK
AKOS005107777
AZU, Fenofibrat
AbZ Brand of Procetofen
Abbott Brand of Procetofen
Aliud Brand of Procetofen
Ankebin
Antara
Antara (TN)
Antara (micronized)
Antara Micronized Procetofen
Anto Brand of Procetofen
Apo Feno Micro
Apo Fenofibrate
Apo-Feno-Micro
Apo-Fenofibrate
Apotex Brand of Procetofen
Azupharma Brand of Procetofen
BIDD:GT0574
BPBio1_000166
BRD-K50388907-001-05-6
BRN 2062462
BSPBio_000150
BSPBio_003162
Bouchara Brand of Procetofen
C07586
C20H21ClO4
CAS-49562-28-9
CCRIS 7282
CHEBI:5001
CHEMBL672
CID3339
CIP-Fenofibrate
CPD000058299
Controlip
D00565
D011345
DB01039
Debat, Fenofibrate
DivK1c_000557
EINECS 256-376-3
EU-0100486
Elasterate
Elasterin
F 6020
F6020_SIGMA
FENOFIBRATE (MICRONIZED)
FNF
Fenobeta
Fenobrate
Fenofanton
Fenofibrat AL
Fenofibrat AZU
Fenofibrat AbZ
Fenofibrat FPh
Fenofibrat Heumann
Fenofibrat Hexal
Fenofibrat Stada
Fenofibrat ratiopharm
Fenofibrat-ratiopharm
Fenofibrate
Fenofibrate (JAN/INN)
Fenofibrate Debat
Fenofibrate IDD-P
Fenofibrate MSD
Fenofibrate [INN:BAN]
Fenofibrato
Fenofibrato [INN-Spanish]
Fenofibratum
Fenofibratum [INN-Latin]
Fenofibric acid
Fenogal
Fenoglide
Fenomax
Fenotard
Finofibrate
Fournier Brand of Procetofen
Fulcro
GNR Pharma Brand of Procetofen
GNR-Pharma Brand of Procetofen
GRS-027
Gate Brand of Procetofen
Gen Fenofibrate
Gen-Fenofibrate
Genpharm Brand of Procetofen
HMS1568H12
HMS1921B17
HMS2090G20
HMS2092B05
HMS501L19
Heumann Brand of Procetofen
Heumann, Fenofibrat
Hexal Brand of Procetofen
Hexal, Fenofibrat
I06-0048
IDI1_000557
Isopropyl (4'-(P-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
KBio1_000557
KBio2_001730
KBio2_004298
KBio2_006866
KBio3_002382
KBioGR_000706
KBioSS_001730
Knoll Brand of Procetofen
LCP-Feno
LCP-FenoChol
LF 178
 
LF-178
LF178
LS-121256
Lichtenstein Brand of Procetofen
Lipanthyl
Lipantil
Lipantil (TN)
Liparison
Lipidex
Lipidil
Lipidil Micro
Lipidil Supra
Lipidil Ter
Lipidil-Ter
Lipifen
Lipirex
Lipoclar
Lipofen
Lipofen (TN)
Lipofene
Liposit
Lipsin
Lofibra
Lopac-F-6020
Lopac0_000486
Luxacor
MLS000028515
MLS001148191
MTW Brand of Procetofen
MTW Fenofibrat
MTW-Fenofibrat
Merck dura Brand of Procetofen
Micronized Procetofen, Antara
MolPort-002-887-051
NCGC00015437-01
NCGC00015437-02
NCGC00015437-03
NCGC00015437-06
NCGC00015437-12
NCGC00021475-03
NCGC00021475-04
NCGC00021475-05
NCGC00021475-06
NCGC00021475-07
NCGC00021475-08
NINDS_000557
NSC 281319
NSC281319
Nolipax
Novartis Brand of Procetofen
Novo Fenofibrate
Novo-Fenofibrate
Novopharm Brand of Procetofen
Nu Fenofibrate
Nu Pharm Brand of Procetofen
Nu-Fenofibrate
Nu-Pharm Brand of Procetofen
PMS Fenofibrate Micro
PMS-Fenofibrate Micro
Pharmascience Brand of Procetofen
Pharmavit
Phenofibrate
Prestwick0_000275
Prestwick1_000275
Prestwick2_000275
Prestwick3_000275
Prestwick_217
Procetofen
Procetofen Reliant Brand
Procetofen, Antara Micronized
Procetofene
Proctofene
Protolipan
Q Pharm Brand of Procetofen
Q-Pharm Brand of Procetofen
Reliant Brand of Procetofen
S1794_Selleck
SAM002264613
SMR000058299
SPBio_001380
SPBio_002369
SPECTRUM1501010
ST085313
Schering Plough Brand of Procetofen
Schering-Plough Brand of Procetofen
Secalip
Sedufen
Spectrum2_001390
Spectrum3_001431
Spectrum4_000413
Spectrum5_001479
Spectrum_001250
Stada, Fenofibrat
Stadapharm Brand of Procetofen
Supralip
TL8003296
TRICOR (MICRONIZED)
Tricor
Tricor (TN)
Triglide
Triglide (TN)
Trilipix
UNII-U202363UOS
United Drug Brand of Procetofen
ZINC00584092
betapharm Brand of Procetofen
ct Arzneimittel Brand of Procetofen
ct-Arzneimittel Brand of Procetofen
durafenat
fenofibrat von ct
fenofibrate
fenofibric acid
isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
nchembio790-comp24
ratiopharm Brand of Procetofen
13Calcium, DietaryPhase 35713
14Pharmaceutical SolutionsPhase 38192
15ImmunoglobulinsPhase 3, Phase 26394
16AntibodiesPhase 3, Phase 26394
17Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 3, Phase 21998
18Rosuvastatin CalciumPhase 3476147098-20-2
19Atorvastatin CalciumPhase 3760134523-03-8
20Antibodies, MonoclonalPhase 3, Phase 24039
21
TorcetrapibPhase 315262352-17-0159325
Synonyms:
(2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
262352-17-0
AC1L4LN3
CHEBI:49203
CHEBI:617982
CHEMBL479527
CID159325
CP 529414
CP-529,414
 
CP-529414
D06195
Ethyl (2R,4S)-4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
LS-187027
LS-187649
Torcetrapib
Torcetrapib (USAN/INN)
Torcetrapib [USAN]
ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
22Trace ElementsPhase 26001
23MicronutrientsPhase 26001
24
CobaltPhase 21677440-48-4104729
Synonyms:
Aquacat
Co
 
Cobalt-59
Cobatope-57
Kobalt
Super cobalt
25PhytosterolNutraceutical118

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1A Study of the Safety and Efficacy of Patients With Familial Hypercholesterolaemia Taking Colesevelam as add-on Therapy to Their Existing MedicationCompletedNCT00655265Phase 4
2Type III DysbetalipoproteinemiaCompletedNCT00214604Phase 3
3A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH)CompletedNCT00730236Phase 3
4Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT00943306Phase 3
5A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384)CompletedNCT02460159Phase 3
6The APPROACH Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Patients With Familial Chylomicronemia SyndromeCompletedNCT02211209Phase 3
7A Randomized, Double-blind, Placebo Controlled Study to Assess Efficacy, Safety and Tolerability of LCQ908 in Subjects With Familial Chylomicronemia SyndromeCompletedNCT01514461Phase 3
8Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN)CompletedNCT02107898Phase 3
9A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial HypercholesterolemiaCompletedNCT01968980Phase 3
10A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-833)Active, not recruitingNCT02748057Phase 3
11Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Subjects With A Genetic Cholesterol Disorder.TerminatedNCT00145431Phase 3
12Efficacy and Safety Study of Eprotirome in HeFH Patients Who Are on Optimal Standard of CareTerminatedNCT01410383Phase 3
13Study to Evaluate the Effects of MBX-8025 in Patients With HoFHCompletedNCT02472535Phase 2
14Efficacy and Safety of Gemcabene in Patients With Homozygous Familial Hypercholesterolemia on Stable, Lipid-Lowering Therapy (COBALT-1)RecruitingNCT02722408Phase 2
15Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)Active, not recruitingNCT02597127Phase 2
16An Extension Trial of Inclisiran Compared to Evolocumab in Participants With Cardiovascular Disease and High CholesterolNot yet recruitingNCT03060577Phase 2
17DARK STUDY "DysbetalipoproteinemiA and atheRoma Risk"Unknown statusNCT01760265
18Effect of Weight Loss on Cholesterol Metabolism in Hereditary Hypercholesterolemias and Overweight or Obesity.CompletedNCT01995149
19Evaluation of LipoproteinsRecruitingNCT00001168
20The Spanish Familial Hypercholesterolaemia Cohort StudyRecruitingNCT02693548

Search NIH Clinical Center for Hyperlipoproteinemia Type Iii


Cochrane evidence based reviews: hyperlipoproteinemia type iii

Genetic Tests for Hyperlipoproteinemia Type Iii

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Genetic tests related to Hyperlipoproteinemia Type Iii:

id Genetic test Affiliating Genes
1 Familial Type 3 Hyperlipoproteinemia27

Anatomical Context for Hyperlipoproteinemia Type Iii

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Publications for Hyperlipoproteinemia Type Iii

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Articles related to Hyperlipoproteinemia Type Iii:

idTitleAuthorsYear
1
Apolipoprotein E phenotyping--useful in the study of hyperlipoproteinemia type III]. (8480294)
1993
2
Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1). (1973700)
1990
3
Serum and interstitial fluid apolipoprotein E levels in the healthy and in hyperlipoproteinemia type III as studied by radioimmunoassay. (4042371)
1985
4
Apolipoprotein E (role in lipoprotein metabolism and pathophysiology of hyperlipoproteinemia type III). (6283616)
1982
5
Polymorphism of apolipoprotein E. II. Genetics of hyperlipoproteinemia type III. (215360)
1979
6
Polymorphism of apolipoprotein E. I. Methodological aspects and diagnosis of hyperlipoproteinemia type III without ultracentrifugation. (215358)
1978
7
Familial hyperlipoproteinemia type III: deficiency of a specific apolipoprotein (apo E-III) in the very-low-density lipoproteins. (169165)
1975

Variations for Hyperlipoproteinemia Type Iii

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Expression for genes affiliated with Hyperlipoproteinemia Type Iii

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Search GEO for disease gene expression data for Hyperlipoproteinemia Type Iii.

Pathways for genes affiliated with Hyperlipoproteinemia Type Iii

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Pathways related to Hyperlipoproteinemia Type Iii according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.9APOE, LDLR
29.6APOA1, APOB
39.5APOA1, APOA5
49.4HMGCR, LDLR
5
Show member pathways
9.3APOA1, APOB, APOE
69.2APOA1, APOA5, APOE
79.2APOA1, APOA5, LPL
89.0HMGCR, LDLR, LPL
9
Show member pathways
9.0APOA1, APOB, APOE, LDLR
10
Show member pathways
8.7APOA1, APOB, APOE, LDLR, LPL
11
Show member pathways
8.7APOA1, APOB, APOE, LDLR, LPL
12
Show member pathways
7.3APOA1, APOA5, APOB, APOE, CETP, LDLR
13
Show member pathways
6.7APOA1, APOA5, APOB, APOE, CETP, HMGCR
14
Show member pathways
6.0APOA1, APOA5, APOB, APOE, CETP, HMGCR

GO Terms for genes affiliated with Hyperlipoproteinemia Type Iii

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Cellular components related to Hyperlipoproteinemia Type Iii according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.4APOB, APOE, LDLR
2endocytic vesicle lumenGO:007168210.1APOA1, APOB, APOE
3blood microparticleGO:007256210.0APOA1, APOA5, APOE
4early endosomeGO:00057699.8APOA1, APOB, APOE, LDLR
5intermediate-density lipoprotein particleGO:00343639.7APOA1, APOB, APOE
6chylomicronGO:00426279.4APOA1, APOA5, APOB, APOE, LPL
7endoplasmic reticulum lumenGO:00057889.4APOA1, APOA5, APOB, APOE, LIPC
8low-density lipoprotein particleGO:00343629.0APOA1, APOA5, APOB, APOE, LDLR
9high-density lipoprotein particleGO:00343648.9APOA1, APOA5, APOE, CETP, LIPC
10very-low-density lipoprotein particleGO:00343618.6APOA1, APOA5, APOB, APOE, LPL
11extracellular regionGO:00055768.3APOA1, APOA5, APOB, APOE, CETP, LIPC
12extracellular spaceGO:00056157.6APOA1, APOA5, APOB, APOE, CETP, LDLR

Biological processes related to Hyperlipoproteinemia Type Iii according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1artery morphogenesisGO:004884410.7APOB, APOE
2low-density lipoprotein particle clearanceGO:003438310.7APOB, LDLR
3positive regulation of cholesterol storageGO:001088610.6APOB, LPL
4positive regulation of macrophage derived foam cell differentiationGO:001074410.6APOB, LPL
5lipid homeostasisGO:005508810.6APOE, CETP
6regulation of lipoprotein lipase activityGO:005100410.6LIPC, LPL
7phosphatidylcholine metabolic processGO:004647010.5APOA5, CETP
8lipoprotein catabolic processGO:004215910.4APOB, APOE, LDLR
9high-density lipoprotein particle clearanceGO:003438410.4APOA1, APOE
10regulation of Cdc42 protein signal transductionGO:003248910.3APOA1, APOE
11cholesterol importGO:007050810.3APOA1, LDLR
12lipid catabolic processGO:001604210.3APOB, LIPC, LPL
13positive regulation of fatty acid biosynthetic processGO:004572310.2APOA1, APOA5
14positive regulation of lipoprotein lipase activityGO:005100610.2APOA1, APOA5
15positive regulation of triglyceride catabolic processGO:001089810.2APOA1, APOA5
16regulation of intestinal cholesterol absorptionGO:003030010.2APOA1, APOA5
17phospholipid homeostasisGO:005509110.2APOA1, CETP
18regulation of cholesterol biosynthetic processGO:004554010.1APOB, HMGCR
19very-low-density lipoprotein particle clearanceGO:003444710.1APOB, APOE
20chylomicron assemblyGO:003437810.1APOA1, APOB, APOE
21lipoprotein biosynthetic processGO:004215810.1APOA1, APOB, APOE
22chylomicron remnant clearanceGO:003438210.1APOB, APOE, LDLR, LIPC
23high-density lipoprotein particle assemblyGO:003438010.0APOA1, APOA5, APOE
24neuron projection regenerationGO:003110210.0APOA1, APOA5, APOE
25phospholipid effluxGO:003370010.0APOA1, APOA5, APOE
26positive regulation of cholesterol esterificationGO:001087310.0APOA1, APOA5, APOE
27phospholipid transportGO:00159149.9APOA1, CETP, LDLR
28chylomicron remodelingGO:00343719.8APOA1, APOB, APOE, LPL
29retinoid metabolic processGO:00015239.7APOA1, APOB, APOE, LPL
30cellular protein metabolic processGO:00442679.7APOA1, APOA5, APOB, APOE
31cholesterol effluxGO:00333449.7APOA1, APOA5, APOB, APOE
32post-translational protein modificationGO:00436879.7APOA1, APOA5, APOB, APOE
33low-density lipoprotein particle remodelingGO:00343749.7APOB, APOE, CETP, LIPC, LPA
34high-density lipoprotein particle remodelingGO:00343759.6APOA1, APOE, CETP, LIPC
35cholesterol biosynthetic processGO:00066959.4APOA1, APOA5, HMGCR
36regulation of lipid metabolic processGO:00192169.4APOA1, APOA5, HMGCR
37triglyceride metabolic processGO:00066419.4APOA5, APOE, CETP, LPL
38receptor-mediated endocytosisGO:00068989.4APOA1, APOB, APOE, CETP, LDLR
39cholesterol transportGO:00303019.3APOA1, APOB, CETP, LDLR, LIPC
40reverse cholesterol transportGO:00436919.2APOA1, APOA5, APOE, CETP, LIPC
41very-low-density lipoprotein particle remodelingGO:00343729.1APOE, CETP, LIPC, LPL
42triglyceride catabolic processGO:00194338.8APOA1, APOA5, APOB, APOE, LIPC, LPL
43lipid transportGO:00068698.7APOA1, APOA5, APOB, APOE, CETP, LDLR
44triglyceride homeostasisGO:00703288.6APOA1, APOA5, APOE, CETP, LIPC, LPL
45steroid metabolic processGO:00082028.5APOA1, APOB, APOE, CETP, HMGCR, LDLR
46lipoprotein metabolic processGO:00421578.4APOA1, APOA5, APOB, APOE, CETP, LDLR
47cholesterol homeostasisGO:00426328.3APOA1, APOA5, APOB, APOE, CETP, LDLR
48cholesterol metabolic processGO:00082038.2APOA1, APOB, APOE, CETP, HMGCR, LDLR
49transportGO:00068108.0APOA1, APOA5, APOB, APOE, CETP, COG2
50lipid metabolic processGO:00066297.6APOA1, APOB, APOE, CETP, HMGCR, LDLR

Molecular functions related to Hyperlipoproteinemia Type Iii according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1lipase bindingGO:003547310.5APOA5, APOB
2low-density lipoprotein particle bindingGO:003016910.4LDLR, LIPC
3phospholipase activityGO:000462010.4LIPC, LPL
4beta-amyloid bindingGO:000154010.3APOA1, APOE
5apolipoprotein bindingGO:003418510.2LIPC, LPA, LPL
6lipoprotein particle bindingGO:007181310.2APOA1, APOE
7low-density lipoprotein particle receptor bindingGO:005075010.1APOA5, APOB, APOE
8triglyceride bindingGO:001712910.1CETP, LPL
9triglyceride lipase activityGO:00048069.8LIPC, LPL
10phospholipid transporter activityGO:00055489.8APOA1, CETP
11phosphatidylcholine-sterol O-acyltransferase activator activityGO:00602289.8APOA1, APOA5, APOE
12phosphatidylcholine bindingGO:00312109.6APOA1, APOA5, CETP
13lipid transporter activityGO:00053199.5APOA1, APOB, APOE, CETP
14cholesterol bindingGO:00154859.5APOA1, APOA5, APOE, CETP
15phospholipid bindingGO:00055439.4APOA1, APOA5, APOB, APOE
16heparin bindingGO:00082019.3APOA5, APOB, APOE, LIPC, LPA, LPL
17cholesterol transporter activityGO:00171279.2APOA1, APOA5, APOB, APOE, CETP
18lipid bindingGO:00082899.1APOA1, APOA5, APOB, APOE, CETP

Sources for Hyperlipoproteinemia Type Iii

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet