MCID: HYP011
MIFTS: 34

Hyperlipoproteinemia Type Iii malady

Genetic category

Summaries for Hyperlipoproteinemia Type Iii

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33MalaCards
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MalaCards: Hyperlipoproteinemia Type Iii, also known as familial type 3 hyperlipoproteinemia, is related to hyperlipidemia type 3 and hyperlipoproteinemia type v. An important gene associated with Hyperlipoproteinemia Type Iii is APOA5 (apolipoprotein A-V), and among its related pathways are SREBF and miR33 in cholesterol and lipid homeostasis and A-beta Uptake & Degradation. The compounds alpha tocopherol and palmitate have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Hyperlipoproteinemia Type Iii

Sources:
8Disease Ontology, 22GTR, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic


Aliases & Descriptions:

hyperlipoproteinemia type iii 8 61
familial type 3 hyperlipoproteinemia 8 22
familial hypercholesterolaemia with hyperlipaemia 8
carbohydrate induced hyperlipemia 8
remnant hyperlipidemia 8


External Ids:

Disease Ontology8 DOID:3145
NCIt40 C34710
SNOMED-CT57 42569002, 398796005
MeSH35 D006952

Related Diseases for Hyperlipoproteinemia Type Iii

Sources:
17GeneCards, 18GeneDecks
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Diseases in the hyperlipoproteinemia type v family:

hyperlipoproteinemia type iii hyperlipoproteinemia type iv
hyperlipoproteinemia type 2 hyperlipoproteinemia, type ib

Diseases related to Hyperlipoproteinemia Type Iii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1hyperlipidemia type 330.7COG2, APOA1, APOE, APOA5, LDLR, CETP
2hyperlipoproteinemia type v30.4LPL, APOE
3hyperlipoproteinemia type iv10.3
4ischemic heart disease10.0LPL
5lipoprotein lipase deficiency10.0LPL
6acromegaly10.0LPA
7hepatitis10.0LDLR
8ischemia10.0HMGCR
9psoriasis10.0LDLR
10thromboembolism10.0APOA1
11hyperthyroidism10.0LDLR
12schizophrenia10.0LDLR
13pancreatitis10.0LPL
14smith-lemli-opitz syndrome10.0HMGCR
15myositis10.0HMGCR
16breast cancer10.0LDLR
17abdominal aortic aneurysm10.0APOE
18lipoprotein glomerulopathy10.0APOE
19chylomicron retention disease10.0APOB
20hyperuricemia10.0APOB
21cerebral atherosclerosis10.0APOA1
22sitosterolemia10.0HMGCR
23colorectal cancer10.0LDLR, LPL
24arthritis10.0HMGCR
25complete lcat deficiency10.0LPA, APOA1
26familial hypertriglyceridemia10.0LPL, APOB
27cholestasis10.0CETP, LIPC
28alcohol abuse10.0COG2
29polycystic ovary syndrome10.0LIPC, APOA1
30hyperhomocysteinemia10.0LPA, APOE
31lipase deficiency combined10.0LPL, LIPC
32hepatocellular carcinoma10.0LIPC, LDLR
33arcus senilis10.0APOA1, APOB
34hyperinsulinism10.0APOB, LPL
35amyloidosis, secondary10.0APOA1, LPA
36hepatitis c10.0LDLR, HMGCR, LPL
37hypothyroidism10.0CETP, LPA, APOB
38stroke, hemorrhagic10.0APOE, HMGCR
39age related macular degeneration10.0APOE, APOB
40venous thrombosis10.0CETP, HMGCR, APOB
41alzheimer disease type 210.0APOE, CETP
42vascular dementia10.0APOE, LPA
43retinal disease10.0CETP, LPL, LPA
44uremia10.0LPA, LPL, LIPC, LDLR
45dementia10.0APOE, LPA, LPL, CETP
46familial hypercholesterolemia10.0APOB, HMGCR, CETP, LDLR
47lipodystrophy10.0LDLR, HMGCR, LPL, APOB
48acute myocardial infarction10.0APOB, APOA1, HMGCR, LPA
49aortic disease10.0APOE, LDLR
50glucose intolerance10.0COG2, APOB, LPL

Graphical network of the top 20 diseases related to Hyperlipoproteinemia Type Iii:



Diseases related to hyperlipoproteinemia type iii

Clinical Features for Hyperlipoproteinemia Type Iii

Drugs & Therapeutics for Hyperlipoproteinemia Type Iii

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hyperlipoproteinemia Type Iii

Drug clinical trials:

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Search NIH Clinical Center for Hyperlipoproteinemia Type Iii

Search CenterWatch for Hyperlipoproteinemia Type Iii

Genetic Tests for Hyperlipoproteinemia Type Iii

Sources:
22GTR
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Genetic tests related to Hyperlipoproteinemia Type Iii:

id Genetic test Affiliating Genes
1 Familial Type 3 Hyperlipoproteinemia22

Anatomical Context for Hyperlipoproteinemia Type Iii

Animal Models for Hyperlipoproteinemia Type Iii or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hyperlipoproteinemia Type Iii:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.6APOA1, APOE, APOB, LPL, LDLR
2MP:00053767.1APOA1, APOE, APOA5, APOB, LPL, LIPC

Publications for Hyperlipoproteinemia Type Iii

Genetic Variations for Hyperlipoproteinemia Type Iii

Expression for genes affiliated with Hyperlipoproteinemia Type Iii

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperlipoproteinemia Type Iii

Search GEO for disease gene expression data for Hyperlipoproteinemia Type Iii.

Pathways for genes affiliated with Hyperlipoproteinemia Type Iii

Sources:
38NCBI BioSystems Database, 53R&D Systems, 30KEGG, 12EMD Millipore, 54Reactome, 50PharmGKB
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Pathways related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7HMGCR, LDLR
29.5LDLR, APOE
39.4LPL, APOA5, APOA1
49.4CETP, APOB
59.4CETP, APOB
6
Hide members
9.3LPL, HMGCR, LDLR
7
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9.3HMGCR, APOA5, APOA1
89.2APOB, APOA1
99.2APOB, APOA1
108.9APOA1, APOB, LPA
118.8LDLR, APOB, APOA1
128.7APOB, LPA, CETP, LDLR
13
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8.6APOA1, APOE, APOB
148.6APOA1, APOE, APOB
157.9LDLR, LPL, APOB, APOE, APOA1
16
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7.9LDLR, LPL, APOB, APOE, APOA1
17
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7.2APOA1, APOE, APOB, LPA, LPL, CETP
18
Hide members
7.1LIPC, LPL, LPA, APOB, APOA5, APOE
19
Hide members
6.3LDLR, APOA1, APOE, APOA5, APOB, LPL

Compounds for genes affiliated with Hyperlipoproteinemia Type Iii

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4510.1LDLR, LPL
2palmitate459.6COG2, CETP, LDLR
3xbai459.5APOE, LPL, LDLR
4sele458.9LPL, LDLR, CETP, APOE
5psyllium458.9HMGCR, APOB, LDLR, CETP
6dimyristoylphosphatidylcholine458.8APOE, LDLR, APOA1, LPA, APOA5
7fenofibric acid45 299.6APOA1, APOB, LPL, HMGCR
8colestipol458.6APOB, APOA1, HMGCR, COG2
9acipimox45 299.5HMGCR, CETP, APOB, APOA1
10mspi458.4CETP, LDLR, LPA, APOB, APOA1
11ciprofibrate45 299.4LDLR, HMGCR, LPL, APOB, APOA1
12campesterol45 249.4HMGCR, APOB, APOE, APOA1
13tocopherol458.3LDLR, HMGCR, LPL, APOB, APOA1
14dextran sulfate458.3LDLR, CETP, LPL, APOB, APOA1
15lathosterol45 249.3CETP, HMGCR, LDLR, APOE, APOB
167-ketocholesterol45 249.2APOE, HMGCR, APOB, APOA1
17stearic acid45 11 2410.1LDLR, CETP, LIPC, LPL, COG2
18oleic acid45 29 11 2411.1APOB, LPA, LPL, LIPC, CETP, LDLR
19retinyl palmitate45 249.1LPL, APOB, APOE, APOA1, COG2
20ezetimibe45 119.0CETP, HMGCR, APOA1, COG2, LDLR, APOB
21rosuvastatin45 50 29 1111.0APOB, LDLR, CETP, HMGCR, APOA1, COG2
22intralipid457.8CETP, LIPC, LPL, APOB, APOE, APOA1
23heparin45 29 11 2410.8LDLR, CETP, LIPC, HMGCR, COG2, APOA5
24pioglitazone45 50 29 1110.7COG2, APOA1, LIPC, LPL, APOB
25homocysteine45 248.7APOB, COG2, CETP, APOE, APOA1, LPA
26cholestyramine457.5APOB, APOE, COG2, LPA, HMGCR, CETP
27cyclosporin a45 29 609.4CETP, APOE, LPL, LIPC, HMGCR, LDLR
28niacin45 118.4LDLR, CETP, COG2, APOA1, APOB, LPA
29fatty acid457.3APOA5, APOB, LPA, COG2, LPL, CETP
30phosphatidylcholine457.1LPA, LDLR, APOE, APOB, APOA1, CETP
31vitamin a45 11 249.1APOE, LPL, LPA, APOB, LIPC, APOA1
32pravastatin45 50 29 11 2411.1COG2, APOA1, APOE, APOB, LPA, HMGCR
33fluvastatin45 50 29 1110.0LDLR, CETP, HMGCR, LPL, APOB, APOE
34probucol45 118.0APOA1, APOE, LDLR, CETP, HMGCR, LIPC
35aspirin45 50 29 2410.0LPA, LDLR, APOB, APOE, APOA1, COG2
36phospholipid456.9APOE, APOB, COG2, LDLR, LPL, LIPC
37sterol456.8HMGCR, APOE, COG2, APOA1, LDLR, CETP
38simvastatin45 50 60 29 11 2411.7COG2, APOA1, APOE, APOB, LPA, LPL
39testosterone45 60 11 249.7LPL, COG2, CETP, APOA1, LIPC, APOB
40triacylglycerol456.7COG2, LDLR, CETP, LIPC, LPL, APOB
41fenofibrate45 50 118.6LDLR, CETP, HMGCR, LIPC, LPL, LPA
42estrogen456.4COG2, APOA1, LDLR, APOB, CETP, LPA
43cholesterol ester456.2CETP, LDLR, APOA1, COG2, APOE, APOB
44atorvastatin45 50 29 11 2410.2COG2, APOA1, APOE, APOB, LPA, LPL
45bezafibrate45 29 118.2LDLR, CETP, HMGCR, LIPC, LPL, LPA
46gemfibrozil45 29 118.2LDLR, COG2, CETP, HMGCR, APOE, APOA1
47thyroxine45 247.2APOA1, COG2, LDLR, CETP, HMGCR, LIPC
48lovastatin45 50 60 29 1110.2COG2, APOE, APOB, LPA, LPL, LDLR
49cholesterol45 29 11 248.9LDLR, CETP, HMGCR, LIPC, LPL, LPA
50lipid455.9CETP, HMGCR, LIPC, LPL, LPA, APOB

GO Terms for genes affiliated with Hyperlipoproteinemia Type Iii

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:0306699.3LDLR, APOB
2intermediate-density lipoprotein particleGO:0343638.7APOB, APOE
3endocytic vesicle lumenGO:0716828.6APOB, APOE, APOA1
4chylomicronGO:0426278.6APOE, APOA5, APOB, LPL
5low-density lipoprotein particleGO:0343628.5LDLR, APOB, APOA5, APOE
6high-density lipoprotein particleGO:0343648.5APOA1, APOE, APOA5, LIPC, CETP
7early endosomeGO:0057698.2APOA1, APOE, APOB, LDLR
8very-low-density lipoprotein particleGO:0343618.2LPL, APOB, APOA5, APOE, APOA1
9extracellular spaceGO:0056157.2APOA1, APOE, APOA5, APOB, LPL, LIPC
10extracellular regionGO:0055767.2APOA1, APOE, APOA5, APOB, LPA, LPL

Biological processes related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1phospholipid transportGO:01591410.0CETP, LDLR
2cholesterol importGO:07050810.0LDLR, APOA1
3lipid transportGO:0068699.9CETP, LPA, APOA5
4phospholipid homeostasisGO:0550919.9CETP, APOA1
5regulation of Cdc42 protein signal transductionGO:0324899.7APOA1, APOE
6peripheral nervous system axon regenerationGO:0140129.7APOE, APOA1
7high-density lipoprotein particle assemblyGO:0343809.7APOE, APOA1
8high-density lipoprotein particle clearanceGO:0343849.7APOA1, APOE
9positive regulation of cholesterol esterificationGO:0108739.6APOE, APOA1
10cholesterol biosynthetic processGO:0066959.6HMGCR, APOA1
11chylomicron remnant clearanceGO:0343829.6APOE, LIPC
12positive regulation of cholesterol storageGO:0108869.5LPL, APOB
13phospholipid effluxGO:0337009.5APOE, APOA1
14low-density lipoprotein particle clearanceGO:0343839.5APOB, LDLR
15positive regulation of macrophage derived foam cell differentiationGO:0107449.4LPL, APOB
16cellular lipid metabolic processGO:0442559.3APOA1, APOA5, HMGCR
17triglyceride metabolic processGO:0066419.3APOE, APOA5, LPL, CETP
18negative regulation of MAP kinase activityGO:0434079.1HMGCR, APOE
19very-low-density lipoprotein particle remodelingGO:0343729.1CETP, LIPC, LPL, APOE
20lipoprotein catabolic processGO:0421599.0LDLR, APOB, APOE
21triglyceride homeostasisGO:0703289.0APOA1, APOA5, LPL, LIPC, CETP
22high-density lipoprotein particle remodelingGO:0343759.0APOA1, APOE, LIPC, CETP
23reverse cholesterol transportGO:0436918.9APOA1, APOE, LIPC, CETP
24artery morphogenesisGO:0488448.9APOB, APOE
25lipoprotein biosynthetic processGO:0421588.9APOB, APOE, APOA1
26cholesterol effluxGO:0333448.9APOA1, APOE, APOB
27cholesterol transportGO:0303018.9APOA1, APOB, CETP, LDLR
28triglyceride catabolic processGO:0194338.9APOA5, APOB, LPL, LIPC
29low-density lipoprotein particle remodelingGO:0343748.6APOE, APOB, LIPC, CETP
30receptor-mediated endocytosisGO:0068988.4LDLR, CETP, LPA, APOB, APOE
31retinoid metabolic processGO:0015238.2APOA1, APOE, APOB, LPL, LDLR
32phototransduction, visible lightGO:0076038.2LDLR, LPL, APOB, APOE, APOA1
33cholesterol metabolic processGO:0082037.8APOA1, APOE, APOB, LIPC, CETP, LDLR
34cholesterol homeostasisGO:0426327.5APOA1, APOE, APOA5, APOB, LIPC, CETP
35lipoprotein metabolic processGO:0421577.4LDLR, APOA1, CETP, LPL, LPA, APOB
36small molecule metabolic processGO:0442816.9APOA1, APOE, APOA5, APOB, LPA, LPL

Molecular functions related to Hyperlipoproteinemia Type Iii according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1triglyceride bindingGO:01712910.1CETP, LPL
2phosphatidylcholine bindingGO:03121010.1APOA5, CETP
3phospholipid transporter activityGO:00554810.0CETP, APOA1
4phospholipase activityGO:0046209.8LIPC, LPL
5low-density lipoprotein particle bindingGO:0301699.7LIPC, LDLR
6phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.7APOA1, APOE
7lipid transporter activityGO:0053199.6APOE, CETP
8triglyceride lipase activityGO:0048069.6LIPC, LPL
9apolipoprotein bindingGO:0341859.6LIPC, LPL, LPA
10cholesterol bindingGO:0154859.4CETP, APOA1
11lipid bindingGO:0082899.4CETP, APOA5, APOE
12beta-amyloid bindingGO:0015409.3APOA1, APOE
13low-density lipoprotein particle receptor bindingGO:0507509.0APOE, APOA5, APOB
14enzyme bindingGO:0198998.9APOB, APOA5, APOA1
15cholesterol transporter activityGO:0171278.6CETP, APOB, APOE, APOA1
16phospholipid bindingGO:0055438.5APOA1, APOE, APOA5, APOB
17heparin bindingGO:0082017.9LIPC, APOE, APOA5, APOB, LPA, LPL

Products for genes affiliated with Hyperlipoproteinemia Type Iii

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  • Proteins
  • Lysates
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Sources for Hyperlipoproteinemia Type Iii

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet