Hyperopia malady

Wikipedia: Hyperopia, also known as farsightedness, longsightedness or hypermetropia, is a defect of vision caused...⁴⁴ more...

MalaCards: Hyperopia is related to leber congenital amaurosis and irregular astigmatism. An important gene associated with Hyperopia is NYX (nyctalopin), and among its related pathways is Wnt signaling pathway. Affiliated tissues include retina, and related mouse phenotypes are pigmentation and hearing/vestibular/ear.

hyperopia 8 32 43

Diseases related to hyperopia by text searches and GeneDecks gene sharing:

(show all 33)

id	Related Disease	Score	Top Affiliating Genes
1	leber congenital amaurosis	27.3	GUCY2D, IMPDH1, CRB1, TULP1, LRAT
2	irregular astigmatism	13.2	NYX, TUSC5
3	interval angle-closure glaucoma	13.1	PRSS56, NNO1, MFRP
4	night blindness	12.9	TULP1, NYX, LRAT
5	x-linked infantile nystagmus	12.9	ROBO3, FRMD7, CNGA3
6	anisometropia	12.8	IFITM2, DSE, DPT
7	cycloplegia	12.7	KERA, DPT, DSE, IFITM2
8	fundus dystrophy	12.7	LRAT, GUCY2D, CRB1, TULP1
9	pigmentary retinopathy	12.7	GUCY2D, RS1, MFRP
10	rhyns syndrome	12.7	CNGA3, GUCY2D, CRB1, TULP1
11	duane retraction syndrome	12.5	ROBO3, CHN1
12	neural tube defect	12.4	VANGL1, VANGL2, FZD6, NOG, MSX2
13	retinal disease	12.3	GUCY2D, TULP1, IMPDH1, CNGA3, CRB1, RS1
14	motor neuro-ophthalmic disorders	12.3	FZD6, NKD1, PRICKLE2, NKD2
15	nystagmus	12.0	RS1, TULP1, IMPDH1, FRMD7, KCNJ13, MYO7A
16	retinal degeneration	11.9	RS1, CRB1, TULP1, LRAT, GUCY2D, IMPDH1
17	myopia 6	11.8	CFP, DSE, TUSC5, DPT, IFITM2, MATK
18	astigmatism	11.7	DSE, DPT, IFITM2, MATK, FRMD7, KIF21A
19	blindness	11.6	CRB1, TULP1, IMPDH1, GUCY2D, CFP, RS1
20	keratoconus	11.5	CNGA3, MYO7A, KERA, KCNJ13, GUCY2D, IMPDH1
21	amblyopia	11.4	DSE, DPT, PRSS56, ROBO3, CHN1, KIF21A
22	retinitis	11.0	IMPDH1, CRB1, NOG, RS1, GUCY2D, LRAT
23	strabismus	9.6	WNT11, NKD2, NKD1, PRICKLE2, RS1, FRMD7
24	angle-closure glaucoma	5.5
25	ankylosis	5.5
26	glaucoma	5.5
27	isolated microphthalmia	5.5
28	microphthalmia	5.5
29	myopia	5.5
30	pilodental dysplasia with refractive errors	5.5
31	refractive error	5.5
32	stapes ankylosis with broad thumb and toes	5.5
33	accommodative spasm	5.5

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hyperopia:

²²

MGI Mouse Phenotypes related to hyperopia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	8.6	CRB1, TULP1, MFRP, MSX2, MYO7A, RS1
2	hearing/vestibular/ear phenotype	MP:0005377	8.5	VANGL1, MYO7A, MSX2, VANGL2, ROBO3, NOG
3	vision/eye phenotype	MP:0005391	7.4	DPT, LRAT, VANGL2, MYO7A, KERA, MSX2
4	reproductive system phenotype	MP:0005389	7.3	VANGL1, VANGL2, MYO7A, MSX2, NOG, DSE
5	nervous system phenotype	MP:0003631	6.1	FZD6, CHN1, CRB1, TULP1, MFRP, GUCY2D

Articles related to hyperopia:

id	Title	Authors	Year	Affiliating Genes
1	Evaluation of MFRP as a candidate gene for high hyperopia. (19169412)	Wang P.... Zhang Q.	2009	MFRP
2	Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia. (18334955)	Metlapally R.... Young T.L.	2008	MFRP
3	A G1103R mutation in CRB1 is co-inherited with high hyperopia and Leber congenital amaurosis. (16543197)	Abouzeid H.... Sundin O.	2006	CRB1
4	Extreme hyperopia is the result of null mutations in MFRP, which encodes a frizzled-related protein. (15976030)	Sundin O.H.... Weinberg E.M.	2005	MFRP
5	Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. (12089654)	Brown D.J.... Lesperance M.M.	2002	NOG
6	Autosomal dominant nanophthalmos (NNO1) with high hyperopia and angle-closure glaucoma maps to chromosome 11. (9792868)	Othman M.I.... Richards J.E.	1998	NNO1

Genes related to hyperopia according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	NYX	nyctalopin	11.1	Summaries
2	NOG	noggin	11.0	Publications
3	CFP	complement factor properdin	11.0
4	GUCY2D	guanylate cyclase 2D, membrane (retina-specific)	11.0
5	NNO1	nanophthalmos 1	11.0	Publications
6	MFRP	membrane frizzled-related protein	11.0	Publications
7	PRSS56	protease, serine, 56	11.0
8	KCNJ13	potassium inwardly-rectifying channel, subfamily J, member 13	11.0
9	IFITM2	interferon induced transmembrane protein 2	11.0	Disorders
10	KERA	keratocan	11.0
11	TULP1	tubby like protein 1	11.0
12	LRAT	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	11.0
13	ADAL	adenosine deaminase-like	11.0	Disorders
14	ZNF692	zinc finger protein 692	11.0	Disorders
15	VANGL2	vang-like 2 (van gogh, Drosophila)	11.0
16	RS1	retinoschisin 1	11.0
17	ROBO3	roundabout, axon guidance receptor, homolog 3 (Drosophila)	11.0
18	TUSC5	tumor suppressor candidate 5	11.0
19	IMPDH1	IMP (inosine 5'-monophosphate) dehydrogenase 1	11.0
20	FZD6	frizzled family receptor 6	11.0
21	CNGA3	cyclic nucleotide gated channel alpha 3	11.0
22	FRMD7	FERM domain containing 7	11.0
23	DPT	dermatopontin	11.0	Disorders
24	MSX2	msh homeobox 2	11.0
25	WNT11	wingless-type MMTV integration site family, member 11	11.0
26	MATK	megakaryocyte-associated tyrosine kinase	11.0	Disorders
27	NKD2	naked cuticle homolog 2 (Drosophila)	11.0
28	NKD1	naked cuticle homolog 1 (Drosophila)	11.0
29	VANGL1	vang-like 1 (van gogh, Drosophila)	11.0
30	MYO7A	myosin VIIA	11.0
31	CRB1	crumbs homolog 1 (Drosophila)	11.0	Publications
32	DSE	dermatan sulfate epimerase	11.0	Disorders
33	PRICKLE2	prickle homolog 2 (Drosophila)	11.0
34	KIF21A	kinesin family member 21A	11.0
35	CHN1	chimerin (chimaerin) 1	11.0

Pathways related to hyperopia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Wnt signaling pathway20	8.1	VANGL1, VANGL2, FZD6, PRICKLE2, NKD1, NKD2

Cellular components related to hyperopia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lateral plasma membrane	GO:016328	9.4	VANGL2, PRICKLE2, NKD2

Biological processes related to hyperopia according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to stimulus	GO:050896	10.1	NYX, KERA, LRAT
2	negative regulation of cartilage development	GO:061037	10.0	WNT11, NOG
3	non-canonical Wnt receptor signaling pathway	GO:035567	10.0	FZD6, WNT11
4	eye photoreceptor cell development	GO:042462	9.5	CRB1, MYO7A, TULP1
5	establishment or maintenance of epithelial cell apical/basal polarity	GO:045197	9.4	PRICKLE2, VANGL2
6	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	9.3	NKD2, NKD1, NOG, FZD6, WNT11
7	visual perception	GO:007601	9.1	LRAT, RS1, NYX, TULP1, GUCY2D, KERA