MCID: HYP068
MIFTS: 40

Hyperostosis malady

Categories: Bone diseases

Aliases & Classifications for Hyperostosis

Aliases & Descriptions for Hyperostosis:

Name: Hyperostosis 12 29 52 42 14 69
Hypertrophy of Bone 12
Bone Hypertrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:205
ICD10 33 M89.3 M89.30
MeSH 42 D015576
NCIt 47 C34712
SNOMED-CT 64 13814009 203514008
UMLS 69 C0020492

Summaries for Hyperostosis

Disease Ontology : 12 A bone remodeling disease that results in an abnormal growth of located in bone.

MalaCards based summary : Hyperostosis, also known as hypertrophy of bone, is related to diffuse idiopathic skeletal hyperostosis and hyperostosis cranialis interna. An important gene associated with Hyperostosis is SOST (Sclerostin). The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and brain.

Wikipedia : 71 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

Related Diseases for Hyperostosis

Diseases related to Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
id Related Disease Score Top Affiliating Genes
1 diffuse idiopathic skeletal hyperostosis 12.4
2 hyperostosis cranialis interna 12.2
3 hyperostosis, endosteal 12.1
4 calvarial hyperostosis 12.1
5 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.0
6 ankylosing vertebral hyperostosis with tylosis diffuse idiopathic skeletal hyperostosis, included 12.0
7 van buchem disease 12.0
8 caffey disease 11.9
9 dysplastic cortical hyperostosis 11.9
10 polyosteolysis/hyperostosis syndrome 11.9
11 ankylosing vertebral hyperostosis with tylosis 11.9
12 sapho syndrome 11.8
13 morgagni-stewart-morel syndrome 11.7
14 tumoral calcinosis, hyperphosphatemic, familial 11.7
15 sclerosteosis 11.7
16 isolated sternocostoclavicular hyperostosis 11.7
17 short stature cranial hyperostosis hepatomegaly 11.7
18 short stature, cranial hyperostosis, hepatomegaly and diabetes 11.7
19 hyperostosis frontalis interna 11.6
20 sclerosteosis 1 11.6
21 osteopathia striata with cranial sclerosis 11.5
22 paget disease of bone 5, juvenile-onset 11.5
23 worth's syndrome 11.4
24 camurati-engelmann disease 11.4
25 craniometaphyseal dysplasia 11.1
26 sclerosteosis 2 11.0
27 exostosis 11.0
28 lenz-majewski hyperostotic dwarfism 10.9
29 weleber hecht bigley syndrome 10.8
30 craniodiaphyseal dysplasia, autosomal dominant 10.8
31 frontometaphyseal dysplasia 2 10.8
32 craniometaphyseal dysplasia, autosomal recessive 10.8
33 paget disease of bone 5, juvenile 10.7
34 pyle disease 10.7
35 ossification of the posterior longitudinal ligament of spine 10.7
36 buschke-ollendorff syndrome 10.7
37 melorheostosis with osteopoikilosis 10.7
38 acne 10.3
39 synovitis 10.3
40 cervicitis 10.3
41 dysphagia 10.3
42 spondylitis 10.2
43 hyperphosphatemia 10.1
44 osteomyelitis 10.0
45 arthritis 9.9
46 calcinosis 9.9
47 spondylosis 9.9
48 lipoma 9.8
49 spinal stenosis 9.8
50 periostitis 9.8

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to Hyperostosis

Symptoms & Phenotypes for Hyperostosis

Drugs & Therapeutics for Hyperostosis

Drugs for Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Immunosuppressive Agents Phase 2
7 Antifungal Agents Phase 2
8 Antibiotics, Antitubercular Phase 2
9
Pamidronate Approved Phase 1 40391-99-9 4674
10 Diphosphonates Phase 1
11 Bone Density Conservation Agents Phase 1
12
Sevelamer Approved 52757-95-6, 152751-57-0 3085017
13
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
14 Analgesics
15 Peripheral Nervous System Agents
16 Chelating Agents
17 Trace Elements
18 Hydroxycholecalciferols
19 Vitamins
20 Micronutrients

Interventional clinical trials:

(show all 19)
id Name Status NCT ID Phase
1 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
2 Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation Recruiting NCT02428296 Phase 2
3 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
4 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
5 Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome Completed NCT02544659 Phase 1
6 Nottingham Osteoarthritis Biomarker Study 2011 Completed NCT01495455
7 Immune Response in the SAPHO Syndrome Completed NCT01688219
8 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
9 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
10 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932
11 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
12 Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease Recruiting NCT02504879
13 Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD) Recruiting NCT01630460
14 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100
15 Hypophosphatemic Rickets in Norway Active, not recruiting NCT01057186
16 Clinical Observation Study With the SBG Stem Active, not recruiting NCT02338661
17 Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal Surgery Enrolling by invitation NCT00984672
18 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
19 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Hyperostosis

Cochrane evidence based reviews: hyperostosis

Genetic Tests for Hyperostosis

Genetic tests related to Hyperostosis:

id Genetic test Affiliating Genes
1 Hyperostosis 29

Anatomical Context for Hyperostosis

MalaCards organs/tissues related to Hyperostosis:

39
Bone, Spinal Cord, Brain, Lung, Testes, Myeloid, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Hyperostosis:

18
Bone

Publications for Hyperostosis

Articles related to Hyperostosis:

(show top 50) (show all 738)
id Title Authors Year
1
Swallowing disorders among patients with diffuse idiopathic skeletal hyperostosis. ( 28084872 )
2017
2
A rare association of dysphagia and cervical compressive myelopathy in diffuse idiopathic skeletal hyperostosis. ( 28084279 )
2017
3
CT-based morphological analysis of spinal fractures in patients with diffuse idiopathic skeletal hyperostosis. ( 27713008 )
2017
4
Prevalence of thoracic diffuse idiopathic skeletal hyperostosis (DISH) in Japanese: Results of chest CT-based cross-sectional study. ( 27697426 )
2017
5
Cross-sectional and Longitudinal Associations of Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Thoracic Kyphosis in Older Men and Women. ( 27723250 )
2016
6
Increased Bone Mineral Density in Cervical or Thoracic Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Case-Control Study. ( 27712986 )
2016
7
Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. ( 27742022 )
2016
8
Is diffuse idiopathic skeletal hyperostosis a disease or a syndrome? Need for studies on angiogenesis-stimulating activity. ( 28013194 )
2016
9
Simultaneous occurrence of ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (Forestier-RotA"s-QuAcrol disease). ( 27131856 )
2016
10
Somatic AKT1 mutations cause meningiomas colocalizing with a characteristic pattern of cranial hyperostosis. ( 27550858 )
2016
11
Refractory Obstructive Sleep Apnea in a Patient with Diffuse Idiopathic Skeletal Hyperostosis. ( 27957370 )
2016
12
Sacroiliitis and Spondylitis with Sternoclavicular Hyperostosis: SAPHO or an Ankylosing Spondylitis Variant? ( 26712445 )
2016
13
Increased serum leptin and visfatin levels in patients with diffuse idiopathic skeletal hyperostosis: a comparative study. ( 27684733 )
2016
14
An Unusual Cause of Pseudopapillary Oedema: Hyperphosphatemic Hyperostosis Syndrome. ( 26757489 )
2016
15
Diffuse Idiopathic Skeletal Hyperostosis Is Associated with Lower Lung Volumes in Current and Former Smokers. ( 27420360 )
2016
16
Bilateral vocal fold paralysis and dysphagia secondary to diffuse idiopathic skeletal hyperostosis. ( 27557480 )
2016
17
The prevalence of diffuse idiopathic skeletal hyperostosis in Japan - the first report of measurement by CT and review of the literature. ( 26948246 )
2016
18
Hyperostosis frontalis interna in female historic skeletal populations: Age, sex hormones and the impact of industrialization. ( 27901271 )
2016
19
Whole Body Magnetic Resonance Imaging Features in Diffuse Idiopathic Skeletal Hyperostosis in Conjunction with Clinical Variables to Whole Body MRI and Clinical Variables in Ankylosing Spondylitis. ( 26669910 )
2016
20
Extrinsic Esophageal Compression by Cervical Osteophytes in Diffuse Idiopathic Skeletal Hyperostosis: A Contraindication to Transesophageal Echocardiography? ( 26603685 )
2016
21
Diffuse idiopathic skeletal hyperostosis: Diagnostic, clinical, and paleopathological considerations. ( 27004482 )
2016
22
Infantile Cortical Hyperostosis: Report of a Case with Observations on Clinical Manifestations, Radiology, and Pathology with a Late Follow-Up of Eight Years. ( 28050300 )
2016
23
Histological characteristics of diffuse idiopathic skeletal hyperostosis. ( 27101345 )
2016
24
Cervical Myeloradiculopathy due to Ossification of the Posterior Longitudinal Ligament with versus without Diffuse Idiopathic Spinal Hyperostosis. ( 27190737 )
2016
25
Dystrophy of the Great Toenail by Subungual Exostosis and Hyperostosis: Three Case Reports with Different Clinical Presentations. ( 27386469 )
2016
26
Cervical Disc Arthroplasty Combined with Interbody Fusion for the Treatment of Cervical Myelopathy with Diffuse Idiopathic Skeletal Hyperostosis: A Case Report. ( 27453242 )
2016
27
Diagnosis of diffuse idiopathic skeletal hyperostosis with chest computed tomography: inter-observer agreement. ( 27097788 )
2016
28
Phenotypic and Genotypic Characterization and Treatment of a Cohort with Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome. ( 27164190 )
2016
29
Sternocostoclavicular Hyperostosis: An Ill-Recognized Disease. ( 27527220 )
2016
30
Coincidence of Eagle Syndrome and Diffuse Idiopathic Skeletal Hyperostosis Presenting With Dysphagia as a Result of Compression of the Hypopharynx. ( 28027183 )
2016
31
Prenatal Presentation of Lethal Variant Infantile Cortical Hyperostosis (Caffey Disease). ( 27110654 )
2016
32
Hyperostosis Following Orbital Exenteration. ( 27254545 )
2016
33
Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a single centre study of a cohort of 164 patients. ( 26917545 )
2016
34
Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis. ( 27920816 )
2016
35
Ureteral injury as a possible complication of vertebral fracture in a patient with ankylosing spinal hyperostosis. ( 27577522 )
2016
36
Hemoptysis as the Presenting Clinical Sign of a T8-T9 Spine Fracture with Diffuse Idiopathic Skeletal Hyperostosis Changes. ( 27418984 )
2016
37
Cord compression and myelopathy due to stress fracture in a patient with diffuse idiopathic skeletal hyperostosis (DISH). ( 26826342 )
2016
38
Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis. ( 27237608 )
2016
39
The Importance of Recognizing Diffuse Idiopathic Skeletal Hyperostosis for Neurosurgeons: A Review. ( 27021643 )
2016
40
Brain Metastases Mimicking Hyperostosis Frontalis Interna on 99mTc HDP Bone Scintigraphy. ( 27556792 )
2016
41
Hyperostosis in siblings. ( 27245539 )
2016
42
Diffuse Idiopathic Skeletal Hyperostosis (DISH) and non small cell lung cancer: case presentation and review of the literature. ( 27238170 )
2016
43
Gingival pustules and sterile diffuse sclerosing osteomyelitis as a feature of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. ( 26619759 )
2016
44
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome - AA challenging diagnosis not to be missed. ( 27263075 )
2016
45
3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women. ( 27279170 )
2016
46
Appearance of Diffuse Idiopathic Skeletal Hyperostosis on Panoramic Images. ( 27317591 )
2016
47
A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome complicated by IgA nephropathy with nephrotic syndrome. ( 28509162 )
2016
48
Hyperostosis frontalis interna in postmenopausal women-Possible relation to osteoporosis. ( 27093135 )
2016
49
Ossified Posterior Longitudinal Ligament With Massive Ossification of the Anterior Longitudinal Ligament Causing Dysphagia in a Diffuse Idiopathic Skeletal Hyperostosis Patient. ( 26266365 )
2015
50
Prenatal Caffey disease (prenatal cortical hyperostosis): severe forms with favorable outcome. ( 25630842 )
2015

Variations for Hyperostosis

Expression for Hyperostosis

Search GEO for disease gene expression data for Hyperostosis.

Pathways for Hyperostosis

GO Terms for Hyperostosis

Sources for Hyperostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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