Hyperostosis disease: drugs, articles, genes, clinical trials

Summaries for Hyperostosis

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⁶Disease Ontology, ⁴⁴Wikipedia, ²²MalaCards
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Wikipedia: Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal...⁴⁴ more...

MalaCards: Hyperostosis, also known as hypertrophy of bone (morphologic abnormality), is related to sost-related sclerosing bone dysplasia and calvarial hyperostosis. An important gene associated with Hyperostosis is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are PTEN Pathway and FAK1 Signaling. The compounds glucose and bleomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Disease Ontology: A bone remodeling disease that results in an abnormal growth of located in bone.⁶

Aliases & Descriptions for Hyperostosis

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⁶Disease Ontology, ⁷diseasecard, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ⁴⁰SNOMED-CT, ²⁴MeSH, ²⁷NCIt
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Aliases & Descriptions:

hyperostosis ⁶ ⁷ ⁸ ³² ⁴³

hypertrophy of bone (morphologic abnormality) ⁶

hypertrophy of bone (disorder) ⁶

hypertrophy of bone ⁶

bone hypertrophy ⁶

hypertrophy ⁴³

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MeSH²⁴ D015576

SNOMED-CT⁴⁰ 203514008, 13814009

NCIt²⁷ C34712

UMLS⁴³ C0020492

Related Diseases for Hyperostosis

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to hyperostosis by text searches and GeneDecks gene sharing:

(show top 50) (show all 348)

id	Related Disease	Score	Top Affiliating Genes
1	sost-related sclerosing bone dysplasia	31.5	KREMEN1, SOST
2	calvarial hyperostosis	31.3	COX4I2, COX4I1
3	diffuse idiopathic skeletal hyperostosis	31.1	RBP4, IGFBP3, IGF1, HLA-B, TMTC1, CYP26C1
4	hypertrophic cardiomyopathy	30.9	IGFBP3, IGF1, HLA-B, COL1A1, TGFB1
5	hypertension	30.5	LRP5, KL, RBP4, BGLAP, CFI, IGFBP3
6	familial tumoral calcinosis	30.0	KL, FGF23, GALNT3
7	calcinosis	28.4	KL, FGF23, ALPL, PTH, SPP1, GALNT3
8	hyperphosphatemic familial tumoral calcinosis	28.2	FGF23, GALNT3
9	aldosteronism	28.0	KL, FGF23, IGF1, HLA-B, SPP1, COL1A1
10	camurati-engelmann disease	27.9	LRP5, BGLAP, TGFB1
11	hyperphosphatemia	27.5	KL, BGLAP, FGF23, ALPL, TNFRSF11B, PTH
12	rabson-mendenhall syndrome	26.8	IGFBP3, IGF1
13	acromegaly	26.7	RBP4, BGLAP, CFI, IGFBP3, IGF1, PTH
14	peritonitis	26.6	RBP4, BGLAP, CFI, FGF23, IGF1, TNFRSF11B
15	prostatitis	26.6	LRP5, KL, RBP4, BGLAP, CFI, FLNA
16	fibrosis	26.5	KL, RBP4, BGLAP, FLNA, IGFBP3, IGF1
17	insulin resistance	26.3	RBP4, BGLAP, CFI, IGFBP3, IGF1, TNFRSF11B
18	nephropathy	25.9	RBP4, FGF23, IGFBP3, IGF1, HLA-B, TNFRSF11B
19	osteosclerosis	25.8	LRP5, BGLAP, ALPL, TNFRSF11B, PTH, SOST
20	prostate disease	25.7	IGFBP3, IGF1, TGFB1
21	prostate carcinoma	25.6	BGLAP, IGFBP3, IGF1, TNFRSF11B, SPP1, TGFB1
22	hydrocephalus	25.5	FLNA, IGFBP3, IGF1, TGFB1
23	muscular dystrophy	25.5	FLNA, IGF1, HLA-B, SPP1, COL6A1, TGFB1
24	type 2 diabetes mellitus	25.4	LRP5, RBP4, BGLAP, IGFBP3, IGF1, SPP1
25	obesity	25.4	LRP5, RBP4, BGLAP, IGFBP3, IGF1, ALPL
26	was-related disorders	24.9	KL, FLNA, IGF1, HLA-B, COL1A1, COL6A1
27	gingivitis	24.8	BGLAP, IGFBP3, ALPL, TNFRSF11B, SPP1, COL1A1
28	blindness	24.6	LRP5, RBP4, BGLAP, FGF23, IGFBP3, IGF1
29	pulmonary disease	24.6	LRP5, RBP4, BGLAP, IGFBP3, IGF1, PTH
30	hypoxia	24.6	LRP5, BGLAP, CFI, IGFBP3, IGF1, SPP1
31	thyroiditis	24.5	RBP4, BGLAP, IGFBP3, IGF1, ALPL, HLA-B
32	anemia	24.1	CFI, IGFBP3, IGF1, ALPL, HLA-B, PTH
33	glomerulonephritis	24.0	RBP4, BGLAP, CFI, TNFRSF11B, SPP1, TGFB1
34	hyperglycemia	23.9	BGLAP, IGFBP3, IGF1, SPP1, TGFB1
35	myopathy	23.8	IGFBP3, IGF1, ALPL, HLA-B, COL6A1, TGFB1
36	adenoma	23.8	BGLAP, IGFBP3, IGF1, ALPL, HLA-B, PTH
37	copd	23.6	BGLAP, IGF1, HLA-B, TNFRSF11B, TGFB1
38	twinning	23.6	RBP4, BGLAP, IGFBP3, IGF1, TNFRSF11B, COL10A1
39	atherosclerosis	23.5	LRP5, KL, RBP4, BGLAP, FGF23, IGFBP3
40	diabetes mellitus	22.9	LRP5, RBP4, BGLAP, FGF23, IGFBP3, IGF1
41	osteoarthritis	22.4	LRP5, KL, BGLAP, GTDC2, IGFBP3, IGF1
42	periodontitis	22.3	BGLAP, IGF1, ALPL, HLA-B, TNFRSF11B, SPP1
43	cholesterol	22.3	LRP4, LRP5, KL, RBP4, BGLAP, CFI
44	carcinoma	22.1	LRP5, KL, RBP4, BGLAP, CFI, FLNA
45	adenocarcinoma	21.4	RBP4, BGLAP, GTDC2, IGFBP3, IGF1, ALPL
46	alzheimer's disease	21.1	RBP4, BGLAP, CFI, FLNA, GTDC2, IGFBP3
47	hepatitis	21.0	RBP4, BGLAP, CFI, FLNA, FGF23, IGFBP3
48	pancreatitis	20.5	LRP5, KL, RBP4, BGLAP, FLNA, IGFBP3
49	arthritis	20.4	LRP5, KL, BGLAP, CFI, IGFBP3, IGF1
50	mass syndrome	13.6	LRP5, SOST

Graphical network of the top 20 diseases related to hyperostosis:

Graphical network of diseases related to hyperostosis

Clinical Features for Hyperostosis

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Drugs & Therapeutics for Hyperostosis

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hyperostosis

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Anatomical Context for Hyperostosis

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¹¹FMA
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FMA organs/tissues related to hyperostosis:

¹¹

Bone

Phenotypes for genes affiliated with Hyperostosis

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²⁵MGI
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MGI Mouse Phenotypes related to hyperostosis:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.4	GALNT3, PTH, KL, LRP5, LRP4
2	respiratory system phenotype	MP:0005388	9.3	ALPL, FGF23, FLNA, KL, LRP4
3	hematopoietic system phenotype	MP:0005397	9.1	COL1A1, COL10A1, PTH, ALPL, FGF23, FLNA
4	craniofacial phenotype	MP:0005382	8.9	COL10A1, CYP26C1, PTH, ALPL, FLNA, LRP5
5	adipose tissue phenotype	MP:0005375	8.6	COL1A1, ALPL, IGF1, IGFBP3, KL, TGFB1
6	reproductive system phenotype	MP:0005389	8.1	GALNT3, TGFB1, KREMEN1, SPP1, ALPL, FGF23
7	muscle phenotype	MP:0005369	7.9	TGFB1, COL6A1, COL1A1, SPP1, ALPL, IGF1
8	skeleton phenotype	MP:0005390	7.6	GALNT3, SOST, KREMEN1, COL10A1, SPP1, PTH
9	mortality/aging	MP:0010768	7.6	COL10A1, CYP26C1, PTH, TNFRSF11B, ALPL, FGF23
10	limbs/digits/tail phenotype	MP:0005371	7.1	LRP4, GALNT3, SOST, KREMEN1, COL1A1, COL10A1
11	cardiovascular system phenotype	MP:0005385	7.0	TGFB1, COL1A1, SPP1, PTH, TNFRSF11B, ALPL
12	homeostasis/metabolism phenotype	MP:0005376	6.9	ALPL, SPP1, COL1A1, TGFB1, SOST, GALNT3
13	immune system phenotype	MP:0005387	6.8	PTH, SPP1, COL10A1, COL1A1, TGFB1, TNFRSF11B
14	cellular phenotype	MP:0005384	6.6	SPP1, COL10A1, COL1A1, COL6A1, TGFB1, CYP26C1
15	growth/size phenotype	MP:0005378	6.2	PTH, SPP1, COL10A1, COL1A1, TGFB1, SOST

Publications for genes affiliated with Hyperostosis

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³⁵PubMed
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Articles related to hyperostosis:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	Familial tumoral calcinosis and hyperostosis-hyperpho sphataemia syndrome are different manifestations of the same disease: novel mis sense mutations in GALNT3. (19830424)	Joseph L.... Delaney D.	2010	GALNT3
2	Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)	Gok F.... Sprecher E.	2009	GALNT3
3	Evidence of enhanced expression of osteopontin in spi nal hyperostosis of the twy mouse. (19770606)	Aiba A.... Yamazaki M.	2009	SPP1, COL10A1
4	Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. (19268275)	Shteyer E.... Elpeleg O.	2009	COX4I1, COX4I2
5	Impaired insulin secretion and uptake in patients wit h diffuse idiopathic skeletal hyperostosis. (19908933)	Eckertova M.... Zorad S.	2009	IGF1, IGFBP3
6	A case of familial tumoral calcinosis/hyperostosis-hy perphosphatemia syndrome due to a compound heterozygous mutation in GALNT3 demo nstrating new phenotypic features. (18982401)	Dumitrescu C.E.... Collins M.T.	2009	GALNT3
7	A novel missense mutation in GALNT3 causing hyperostosis-hyperphosphataemia syndrome. (18322299)	Olauson H.... Larsson T.E.	2008	GALNT3, FGF23
8	Genetic analysis and effect of triiodothyronine and prednisone trial on bone turnover in a patient with craniotubular hyperostosis. (18538647)	Lopez J.M.... Gonzalez G.	2008	LRP5, KREMEN1, SOST
9	Prenatal cortical hyperostosis with COL1A1 gene mutation. (18553566)	Kamoun-Goldrat A.... Le Merrer M.	2008	COL1A1
10	The c.3040C > T mutation in COL1A1 is recurrent in Korean patients with infantile cortical hyperostosis (Caffey disease). (18704262)	Cho T.J.... Choi I.H.	2008	COL1A1
11	Hyperostosis-hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23. (17129170)	Frishberg Y.... Fukumoto S.	2007	GALNT3, FGF23
12	Novel GALNT3 mutations causing hyperostosis-hyperphosphatemia syndrome result in low intact fibroblast growth factor 23 concentrations. (17311862)	Ichikawa S.... Econs M.J.	2007	GALNT3, FGF23
13	A novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders. (15864348)	Gensure R.C.... Jueppner H.	2005	COL1A1
14	COL6A1, the candidate gene for ossification of the posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese. (16227896)	Tsukahara S.... Inoue I.	2005	COL6A1
15	A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene. (15869924)	Balemans W.... Van Hul W.	2005	SOST
16	Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders. (15599692)	Frishberg Y.... Sprecher E.	2005	GALNT3, GTDC2
17	Autosomal dominant hyperostosis/osteosclerosis with high serum alkaline phosphatase activity. (12788869)	Hernandez-Cassis C.... Iglesias Gamarra A.	2003	ALPL
18	Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. (7562783)	De Bandt M.... Kahn M.F.	1995	RBP4
19	Growth promoting peptides in osteoarthritis and diffu se idiopathic skeletal hyperostosis--insulin, insulin-like growth factor-I, gro wth hormone. (7799357)	Denko C.W.... Moskowitz R.W.	1994	IGF1

Genes related to Hyperostosis

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¹³GeneCards
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Genes related to hyperostosis according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	COX4I2	cytochrome c oxidase subunit IV isoform 2 (lung)	11.0	Publications
2	GALNT3	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	11.0	Publications
3	FGF23	fibroblast growth factor 23	11.0	Publications
4	LRP5	low density lipoprotein receptor-related protein 5	11.0	Publications
5	RBP4	retinol binding protein 4, plasma	11.0	Publications
6	SOST	sclerostin	11.0	Publications
7	COX4I1	cytochrome c oxidase subunit IV isoform 1	11.0	Publications
8	COL6A1	collagen, type VI, alpha 1	11.0	Publications
9	CFI	complement factor I	11.0
10	COL1A1	collagen, type I, alpha 1	11.0	Publications
11	FLNA	filamin A, alpha	11.0
12	TMTC1	transmembrane and tetratricopeptide repeat containing 1	11.0
13	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
14	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
15	COL10A1	collagen, type X, alpha 1	11.0	Publications
16	CYP26C1	cytochrome P450, family 26, subfamily C, polypeptide 1	11.0
17	LRP4	low density lipoprotein receptor-related protein 4	11.0
18	ALPL	alkaline phosphatase, liver/bone/kidney	11.0	Publications
19	KL	klotho	11.0
20	KREMEN1	kringle containing transmembrane protein 1	11.0	Publications
21	PTH	parathyroid hormone	11.0
22	SPP1	secreted phosphoprotein 1	11.0	Publications
23	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0
24	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0
25	TGFB1	transforming growth factor, beta 1	11.0
26	HLA-B	major histocompatibility complex, class I, B	11.0
27	GTDC2	glycosyltransferase-like domain containing 2	-8.8	Publications

Expression for genes affiliated with Hyperostosis

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Hyperostosis

Pathways for genes affiliated with Hyperostosis

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³⁶QIAGEN, ⁴¹Thomson Reuters, ¹⁰EMD Millipore, ²⁰KEGG
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Pathways related to hyperostosis according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	PTEN Pathway³⁶	9.9	COL6A1, COL1A1, COL10A1, FGF23
2	FAK1 Signaling³⁶	9.4	SPP1, COL10A1, COL1A1, COL6A1
3	Development_Hedgehog and PTH signaling pathways in bone and cartilage development⁴¹	9.2	COL1A1, SPP1, PTH, BGLAP
4	Development Hedgehog and PTH signaling pathways in bone and cartilage development¹⁰	9.2	BGLAP, PTH, SPP1, COL1A1
5	Focal adhesion²⁰	9.1	COL6A1, COL1A1, SPP1, IGF1, FLNA
6	UPA-UPAR Pathway³⁶	9.1	COL6A1, COL1A1, COL10A1, SPP1
7	Inhibition of Angiogenesis by TSP1³⁶	9.0	SPP1, COL10A1, COL1A1, COL6A1, TGFB1
8	Phospholipase-C Pathway³⁶	8.6	TGFB1, COL6A1, COL1A1, COL10A1, SPP1, IGF1
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis⁴¹	8.6	BGLAP, IGF1, TNFRSF11B, PTH, SPP1, COL1A1
10	MAPK Signaling³⁶	8.6	TGFB1, COL6A1, COL1A1, COL10A1, SPP1, IGF1
11	Transcription Role of VDR in regulation of genes involved in osteoporosis¹⁰	8.6	COL1A1, SPP1, PTH, TNFRSF11B, IGF1, BGLAP
12	Rho Family GTPases³⁶	8.5	TGFB1, COL6A1, COL1A1, COL10A1, SPP1, IGF1
13	ILK Signaling³⁶	8.5	TGFB1, COL6A1, COL1A1, COL10A1, SPP1, IGF1
14	ERK Signaling³⁶	8.4	TGFB1, COL6A1, COL1A1, COL10A1, SPP1, IGF1
15	Molecular Mechanisms of Cancer³⁶	8.3	TGFB1, COL6A1, COL1A1, COL10A1, SPP1, IGF1

Compounds for genes affiliated with Hyperostosis

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³²Novoseek , ⁹DrugBank, ¹⁸HMDB, ³⁴PharmGKB, ⁴²Tocris Bioscience
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Compounds related to hyperostosis according to GeneDecks:

(show top 50) (show all 70)

id	Compound	Score	Top Affiliating Genes
1	glucose³²	10.4	PTH
2	bleomycin³² ⁹ ⁹	12.3	COL1A1, IGF1
3	iplex³²	10.2	IGF1, IGFBP3
4	estradiol³² ⁹ ¹⁸ ⁹	13.1	CFI, TNFRSF11B
5	pge2³²	10.0	TNFRSF11B, SPP1
6	aspartate³²	9.9	RBP4, ALPL, TNFRSF11B
7	dehydroepiandrosterone sulfate³²	9.8	PTH, IGF1, IGFBP3, RBP4
8	androstenedione³² ¹⁸	10.7	RBP4, IGFBP3, IGF1, PTH
9	triiodothyronine³²	9.6	TNFRSF11B, IGF1, IGFBP3, RBP4
10	alizarin³²	9.6	BGLAP, ALPL, SPP1
11	eb 1089³²	9.5	BGLAP, IGFBP3, IGF1
12	alizarin red s³²	9.4	BGLAP, TGFB1
13	pyridinoline³²	9.4	TNFRSF11B, IGF1, IGFBP3, BGLAP
14	pamidronate³² ⁹ ⁹	11.4	BGLAP, TNFRSF11B, PTH
15	raloxifene³² ⁹ ⁹	11.4	BGLAP, IGFBP3, IGF1, TNFRSF11B
16	alendronate³² ⁹ ⁹	11.3	PTH, TNFRSF11B, IGF1, BGLAP
17	titanium³²	9.2	SPP1, TNFRSF11B, BGLAP
18	alpha tocopherol³²	9.2	IGF1, IGFBP3, BGLAP, RBP4
19	clonidine³² ⁹ ⁹	11.2	BGLAP, IGFBP3, IGF1, TGFB1
20	estrone³² ⁹ ¹⁸ ⁹	12.2	PTH, IGF1, IGFBP3, BGLAP
21	deoxypyridinoline³²	9.1	PTH, TNFRSF11B, IGF1, IGFBP3, BGLAP
22	alginate³²	9.1	TGFB1, SPP1, IGF1, BGLAP
23	hydroxyapatite³²	9.0	SPP1, TNFRSF11B, ALPL, FGF23, BGLAP
24	dhea³²	9.0	TNFRSF11B, HLA-B, IGF1, IGFBP3
25	phosphorus³²	8.8	SPP1, PTH, TNFRSF11B, FGF23, BGLAP, RBP4
26	dihydrotestosterone³² ⁹ ¹⁸ ⁹	11.7	TGFB1, TNFRSF11B, IGF1, IGFBP3, BGLAP
27	heparin³² ⁹ ¹⁸ ⁹	11.7	SPP1, TNFRSF11B, FGF23, GTDC2, BGLAP
28	hydroxyproline³² ¹⁸	9.7	TGFB1, COL1A1, PTH, TNFRSF11B, BGLAP
29	25-hydroxyvitamin d³²	8.5	SPP1, PTH, TNFRSF11B, IGF1, IGFBP3, FGF23
30	ascorbic acid³² ¹⁸	9.4	SPP1, TNFRSF11B, IGFBP3, BGLAP, RBP4
31	tamoxifen³² ³⁴ ⁹ ⁹	11.4	TGFB1, PTH, TNFRSF11B, IGF1, IGFBP3, BGLAP
32	sb 203580³² ⁴²	9.2	BGLAP, IGF1, TNFRSF11B, SPP1, TGFB1
33	cholesterol³² ⁹ ¹⁸ ⁹	11.2	SPP1, TNFRSF11B, HLA-B, IGF1, IGFBP3, CFI
34	thyroxine³² ¹⁸	9.1	TGFB1, PTH, TNFRSF11B, IGF1, IGFBP3, CFI
35	testosterone³² ⁹ ¹⁸ ⁹	10.9	SPP1, PTH, TNFRSF11B, HLA-B, IGFBP3, CFI
36	procollagen³²	7.9	TGFB1, COL1A1, SPP1, PTH, TNFRSF11B, IGF1
37	ribonucleic acid³²	7.8	TGFB1, COL1A1, SPP1, PTH, HLA-B, IGF1
38	arginine³²	7.8	COL1A1, SPP1, PTH, HLA-B, IGF1, IGFBP3
39	calcitriol³² ⁴² ⁹ ¹⁸ ⁹	11.7	TGFB1, SPP1, PTH, TNFRSF11B, IGF1, IGFBP3
40	cysteine³²	7.7	SPP1, COL1A1, COL6A1, SOST, TNFRSF11B, ALPL
41	cyclosporin a³² ⁴²	8.6	TGFB1, SPP1, TNFRSF11B, HLA-B, IGFBP3, BGLAP
42	1,25 dihydroxy vitamin d3³²	7.6	LRP5, TGFB1, COL1A1, SPP1, PTH, TNFRSF11B
43	vegf³²	7.5	TGFB1, COL1A1, SPP1, PTH, TNFRSF11B, IGF1
44	creatinine³²	7.2	TGFB1, SPP1, PTH, TNFRSF11B, HLA-B, IGF1
45	estrogen³²	7.2	SOST, TGFB1, COL1A1, SPP1, PTH, TNFRSF11B
46	vitamin d³²	7.1	PTH, SPP1, COL1A1, TGFB1, SOST, TNFRSF11B
47	dexamethasone³² ⁴² ³⁴ ⁹ ⁹	10.8	TGFB1, COL1A1, SPP1, PTH, TNFRSF11B, HLA-B
48	calcium³² ⁹ ¹⁸ ⁹	9.3	TNFRSF11B, PTH, SPP1, COL1A1, SOST, GALNT3
49	retinoic acid³² ⁴² ¹⁸	8.2	HLA-B, TNFRSF11B, SPP1, COL1A1, TGFB1, ALPL
50	serine³²	6.1	TGFB1, COL1A1, SPP1, TNFRSF11B, HLA-B, IGF1

GO Terms for genes affiliated with Hyperostosis

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¹²Gene Ontology
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Cellular components related to hyperostosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor binding protein complex	GO:016942	9.7	IGFBP3, IGF1
2	membrane-bounded vesicle	GO:031988	9.5	BGLAP, SPP1
3	extracellular space	GO:005615	6.1	KL, SOST, TGFB1, COL1A1, SPP1, PTH
4	extracellular region	GO:005576	5.5	PTH, SPP1, COL10A1, COL1A1, COL6A1, TGFB1

Biological processes related to hyperostosis according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	GO:090080	10.0	KL, FGF23
2	regulation of canonical Wnt receptor signaling pathway	GO:060828	10.0	LRP5, KREMEN1
3	Wnt receptor signaling pathway	GO:016055	9.6	SOST, KREMEN1, LRP5, LRP4
4	negative regulation of ossification	GO:030279	9.6	LRP4, TGFB1, SOST
5	positive regulation of bone mineralization	GO:030501	9.3	TGFB1, PTH, KL
6	extracellular matrix organization	GO:030198	9.3	COL6A1, COL1A1, COL10A1, TNFRSF11B
7	osteoblast differentiation	GO:001649	9.0	BGLAP, SPP1, COL1A1
8	positive regulation of transcription, DNA-dependent	GO:045893	9.0	SOST, TGFB1, COL1A1, IGF1, FGF23, LRP5
9	response to vitamin D	GO:033280	8.8	TGFB1, SPP1, ALPL, BGLAP
10	skeletal system development	GO:001501	8.3	BGLAP, IGF1, ALPL, TNFRSF11B, PTH, COL10A1