MCID: HYP068
MIFTS: 50

Hyperostosis malady

Bone diseases category
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Summaries for Hyperostosis

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Wikipedia:65 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

MalaCards based summary: Hyperostosis, also known as hypertrophy of bone, is related to hyperphosphatemia and hyperphosphatemic familial tumoral calcinosis. An important gene associated with Hyperostosis is LRP5 (low density lipoprotein receptor-related protein 5). The compounds 1,25 dihydroxy vitamin d3 and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and spinal cord, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Disease Ontology:8 A bone remodeling disease that results in an abnormal growth of located in bone.

Aliases & Classifications for Hyperostosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Hyperostosis, Aliases & Descriptions:

Name: Hyperostosis 8 10 44 62
Hypertrophy of Bone 8 62
 
Bone Hypertrophy 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:205
NCIt39 C34712
SNOMED-CT57 13814009, 203514008
MeSH34 D015576
ICD1025 M89.3

Related Diseases for Hyperostosis

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Diseases related to Hyperostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1hyperphosphatemia30.7FGF23, GALNT3
2hyperphosphatemic familial tumoral calcinosis30.5FGF23, GALNT3
3calcinosis30.5FGF23, GALNT3
4x-linked hypophosphatemia29.8GALNT3, FGF23
5osteoporosis29.8FGF23, LRP5
6diffuse idiopathic skeletal hyperostosis11.1
7acne10.7
8synovitis10.7
9dysphagia10.7
10cervicitis10.7
11sapho syndrome10.7
12caffey disease10.6
13ankylosing spondylitis10.5
14spondylitis10.5
15hyperostosis corticalis generalisata10.5
16meningioma10.5
17calvarial hyperostosis10.5
18osteomyelitis10.4
19hyperostosis-hyperphosphatemia syndrome10.4
20sost-related sclerosing bone dysplasia10.4
21arthritis10.3
22spondylosis10.3
23worth's syndrome10.2
24dysplastic cortical hyperostosis10.2
25morgagni-stewart-morel syndrome10.2
26diabetes mellitus10.2
27spinal stenosis10.2
28hypervitaminosis a10.2
29lipoma10.2
30hyperostosis corticalis generalisata, benign form of worth with torus palatinus10.2
31exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.2
32x-linked calvarial hyperostosis10.2
33osteoarthritis10.2
34pseudoarthrosis10.2
35psoriatic arthritis10.2
36enthesopathy10.2
37exostosis10.2
38periostitis10.2
39familial tumoral calcinosis10.2
40osteopathia striata cranial sclerosis10.2
41paget disease, juvenile10.2
42polyosteolysis/hyperostosis syndrome10.2
43hyperostosis, endosteal10.2
44quadriplegia10.1
45camurati-engelmann disease10.1
46craniometaphyseal dysplasia10.1
47aspiration pneumonia10.1
48inverted papilloma10.1
49laryngitis10.1
50papilloma10.1

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to hyperostosis

Symptoms for Hyperostosis

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Drugs & Therapeutics for Hyperostosis

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Drug clinical trials:

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Genetic Tests for Hyperostosis

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Anatomical Context for Hyperostosis

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MalaCards organs/tissues related to Hyperostosis:

32
Bone, Spinal cord, Testes, Myeloid, Eye, Brain, Cortex, Heart, Colon, Skin, T cells, Neutrophil

FMA organs/tissues related to Hyperostosis:

14
Bone

Animal Models for Hyperostosis or affiliated genes

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MGI Mouse Phenotypes related to Hyperostosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.7GALNT3, CYP26C1, LRP5
2MP:00053718.5FGF23, GALNT3, CYP26C1, LRP5
3MP:00053788.5FGF23, GALNT3, COX4I2, LRP5
4MP:00053858.0LRP5, GALNT3, RBP4, FGF23
5MP:00053767.6LRP5, COX4I2, GALNT3, RBP4, FGF23

Publications for Hyperostosis

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Articles related to Hyperostosis:

(show top 50)    (show all 632)
idTitleAuthorsYear
1
Hyperostosis-hyperphosphatemia syndrome (HHS): report of two cases with a recurrent mutation and review of the literature. (25153226)
2014
2
Disseminated idiopathic skeletal hyperostosis: diagnostic criteria and clinical significance. (24948172)
2014
3
Avascular necrosis of the hip and diffuse idiopathic skeletal hyperostosis during long-term isotretinoin treatment of epidermolytic ichthyosis due to a novel deletion mutation in KRT10. (24720725)
2014
4
IMAGING DIAGNOSIS-AN ATYPICAL PRESENTATION OF DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (DISH) IN A DOG. (24320791)
2013
5
Genetic basis of hyperostosis cranialis interna. (24422132)
2013
6
A case of psoriasis vulgaris with diffuse idiopathic skeletal hyperostosis involved with ossifications of posterior and anterior longitudinal ligament. (20165950)
2012
7
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
8
Diffuse idiopathic skeletal hyperostosis (DISH). (21771167)
2011
9
Etiopathogenesis of hyperostosis frontalis interna: a mystery still. (21684729)
2011
10
Dysphagia caused by diffuse idiopathic skeletal hyperostosis. (21907632)
2011
11
Quantitative analysis of the anterolateral ossification mass in diffuse idiopathic skeletal hyperostosis of the thoracic spine. (21340711)
2011
12
Crico Arytenoid Joint Fixation in Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Case Report. (22754839)
2011
13
Management of craniofacial hyperostosis in Proteus syndrome. (20216456)
2010
14
Phenotypic manifestations and management of hyperostosis cranialis interna, a hereditary bone dysplasia affecting the calvaria and the skull base. (20140965)
2010
15
Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)
2009
16
Imaging characteristics of diffuse idiopathic skeletal hyperostosis with an emphasis on acute spinal fractures: review. (19696239)
2009
17
The management of spinal injuries in patients with ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis: a comparison of treatment methods and clinical outcomes. (19342927)
2009
18
A novel missense mutation in GALNT3 causing hyperostosis-hyperphosphataemia syndrome. (18322299)
2008
19
The prevalence of diffuse idiopathic skeletal hyperostosis in an outpatient population in The Netherlands. (18528963)
2008
20
Atypical presentation of osteomyelitis, discitis, epidural, and iliopsoas abscess in diffuse idiopathic skeletal hyperostosis (DISH) syndrome. (18688200)
2008
21
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
22
A family with diffuse idiopathic skeletal hyperostosis. (16284348)
2005
23
Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery. (15287538)
2004
24
Parasagittal meningioma en plaque with extracranial extension presenting diffuse massive hyperostosis of the skull. (14751632)
2004
25
Hyperostosis and osteitis in Sapho syndrome: conservative or surgical treatment. (15382585)
2004
26
Spontaneous symptomatic pseudoarthrosis at the T11-T12 intervertebral space with diffuse idiopathic skeletal hyperostosis: a case report. (12923487)
2003
27
Degenerative sternoclavicular arthritis and hyperostosis. (12825539)
2003
28
Sternoclavicular hyperostosis with pathological fracture of the clavicle--a case report. (12767795)
2003
29
A structural chiropractic approach to the management of diffuse idiopathic skeletal hyperostosis. (12704313)
2003
30
Periosteal hyperostosis (exostosis) in DBA/1 male mice. (12051556)
2002
31
Diffuse idiopathic skeletal hyperostosis in a patient with idiopathic retroperitoneal fibrosis: a case report. (12426664)
2002
32
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
33
Hyperextension vertebral body fractures in diffuse idiopathic skeletal hyperostosis: a cause of intravertebral fluidlike collections on MR imaging. (10584819)
1999
34
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
35
Case report. synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. (9161184)
1996
36
A metabolic syndrome in diffuse idiopathic skeletal hyperostosis. A controlled study. (8730125)
1996
37
Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. (8859238)
1996
38
Subcutaneous calcifications in diffuse idiopathic skeletal hyperostosis. (7774094)
1995
39
Hyperostosis of ribs: association with vertebral ossification. (8014935)
1993
40
Growth hormone secretion in diffuse idiopathic skeletal hyperostosis. (1524945)
1992
41
Diffuse idiopathic skeletal hyperostosis causing acute thoracic myelopathy: a case report and discussion. (2181336)
1990
42
Diffuse idiopathic skeletal hyperostosis and situs viscerum inversus. (2585410)
1989
43
Cervical involvement of diffuse idiopathic skeletal hyperostosis with dysphagia and rhinolalia. (3266838)
1988
44
Renal osteodystrophy with facial hyperostosis and 'rubber jaw' in an adult dog. (16031185)
1985
45
Diffuse idiopathic skeletal hyperostosis in a patient with situs inversus. (6860386)
1983
46
An unusual case of diffuse idiopathic skeletal hyperostosis. (6681145)
1983
47
Radiologic aspects of diffuse idiopathic skeletal hyperostosis in the spine. (410264)
1977
48
Infantile cortical hyperostosis of the scapula presenting as an ipsilateral Erb's palsy. (4561478)
1972
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Hypervitaminosis A with infantile cortical hyperostosis. (14850258)
1951

Variations for Hyperostosis

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Expression for genes affiliated with Hyperostosis

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Expression patterns in normal tissues for genes affiliated with Hyperostosis

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Pathways for genes affiliated with Hyperostosis

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Compounds for genes affiliated with Hyperostosis

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Sources:
44Novoseek, 50PharmGKB, 24HMDB, 11DrugBank
See all sources

Compounds related to Hyperostosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
11,25 dihydroxy vitamin d3449.4FGF23, LRP5
2vitamin d449.4FGF23, LRP5
3phosphorus449.1FGF23, RBP4
4valine448.9RBP4, LRP5
5calcium44 50 24 1111.0LRP5, GALNT3, RBP4, FGF23

GO Terms for genes affiliated with Hyperostosis

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Biological processes related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidation-reduction processGO:0551149.5COX4I2, CYP26C1
2negative regulation of osteoblast differentiationGO:0456689.3FGF23, LRP5
3embryonic retina morphogenesis in camera-type eyeGO:0600599.2RBP4, LRP5
4anterior/posterior pattern specificationGO:0099529.2CYP26C1, LRP5

Products for genes affiliated with Hyperostosis

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Sources for Hyperostosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet