Aliases & Classifications for Hyperostosis

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 42NCIt, 59SNOMED-CT, 27ICD10
See all sources

Aliases & Descriptions for Hyperostosis:

Name: Hyperostosis 10 47 12 65 36
Hypertrophy of Bone 10
 
Bone Hypertrophy 10


Classifications:



External Ids:

Disease Ontology10 DOID:205
NCIt42 C34712
SNOMED-CT59 13814009, 203514008
MeSH36 D015576
ICD1027 M89.3

Summaries for Hyperostosis

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Wikipedia:68 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

MalaCards based summary: Hyperostosis, also known as hypertrophy of bone, is related to tumoral calcinosis, hyperphosphatemic, familial and hypervitaminosis a. An important gene associated with Hyperostosis is SOST (Sclerostin), and among its related pathways are Negative regulation of TCF-dependent signaling by WNT ligand antagonists and Osteoblast Signaling. Affiliated tissues include bone, bone and spinal cord, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Disease Ontology:10 A bone remodeling disease that results in an abnormal growth of located in bone.

Related Diseases for Hyperostosis

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Diseases related to Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1tumoral calcinosis, hyperphosphatemic, familial30.9FGF23, GALNT3
2hypervitaminosis a30.7FGF23, GALNT3
3hyperostosis, endosteal30.6ANKH, LRP5, TNFRSF11A
4dysplastic cortical hyperostosis30.5EXT1, EXT2
5bone structure disease29.5ALPL, LRP5, SOST, TNFRSF11A
6osteoporosis29.3ALPL, COL1A1, FGF23, LRP5, SOST, TNFRSF11A
7hyperparathyroidism26.8ALPL, ANKH, COL1A1, COL6A1, COX4I2, EXT1
8diffuse idiopathic skeletal hyperostosis11.1
9acne10.7
10sapho syndrome10.7
11synovitis10.7
12dysphagia10.7
13cervicitis10.7
14caffey disease10.7
15spondylitis10.5
16calvarial hyperostosis10.5
17van buchem disease10.5
18hyperphosphatemia10.5
19osteomyelitis10.4
20exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.4
21tumoral calcinosis10.4
22arthritis10.3
23paget disease of bone 5, juvenile-onset10.3
24osteopathia striata with cranial sclerosis10.3
25spondylosis10.3
26sclerosteosis10.3
27calcinosis10.3
28lipoma10.3
29morgagni-stewart-morel syndrome10.3
30weill-marchesani syndrome 2, dominant10.3LRP5, SOST
31craniometaphyseal dysplasia10.2
32psoriatic arthritis10.2
33lenz-majewski hyperostotic dwarfism10.2
34proteus syndrome, somatic10.2
35camurati-engelmann disease10.2
36spinal stenosis10.2
37periostitis10.2
38x-linked calvarial hyperostosis10.2
39pleural tuberculosis10.2LRP5, SOST
40familial visceral myopathy with external ophthalmoplegia10.2FGF23, GALNT3
41esophageal varix10.2ALPL, LRP5
42oculodentodigital dysplasia10.2
43ghosal hematodiaphyseal syndrome10.2
44sclerosteosis 110.2
45osteoarthritis10.2
46pseudoarthrosis10.2
47enthesopathy10.2
48exostosis10.2
49sost-related sclerosing bone dysplasia10.2
50familial tumoral calcinosis10.2

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to hyperostosis

Symptoms for Hyperostosis

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Drugs & Therapeutics for Hyperostosis

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Drugs for Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EverolimusapprovedPhase 21742159351-69-66442177
Synonyms:
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy
07741_FLUKA
159351-69-6
40-O-(2-hydroxyethyl)-rapamycin
42-O-(2-Hydroxyethyl)rapamycin
Afinitor
Afinitor Disperz
CERTICAN(R)
CHEMBL1201755
Certican
D02714
DB01590
 
Everolimus
Everolimus (JAN/USAN/INN)
Everolimus [USAN]
LS-143292
MolPort-003-847-342
MolPort-003-925-588
NCGC00167512-01
NVP-RAD-001
RAD 001
RAD-001
RAD-001C
RAD001
RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus
S1120_Selleck
SDZ-RAD
UNII-9HW64Q8G6G
VOTUBIA
Zortress
everolimus
2
Sirolimusapproved, investigationalPhase 2174253123-88-95284616, 6436030, 46835353
Synonyms:
(-)-Rapamycin
(-)-rapamycin
1fkb
1pbk
23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29
3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
53123-88-9
A422989, NSC226080
AC-722
AC1L1JH9
AC1L7MJ9
AC1L9ZMV
AY 22989
AY-22989
AY22989
Ambotz53123-88-9
Antibiotic AY 22989
BIDD:PXR0165
Bio1_000293
Bio1_000782
Bio1_001271
Bio2_000375
Bio2_000855
BiomolKI2_000084
C07909
C51H79NO13
CBiol_002007
CCRIS 9024
CHEBI:100923
CHEBI:9168
CHEMBL413
CID10213190
CID10795871
CID11949238
CID11959112
CID313006
CID478951
CID5040
CID5284616
CID5358081
CID5374464
CID5460439
CID5497196
CID5924240
CID6436030
CID6610270
CID6610346
CID6711160
CID6713081
CID9833581
CID9854379
CID9854380
CID9962926
CID9962928
D00753
DB00877
DE-109
DivK1c_006936
 
FT-0082351
HMS2089A21
HSDB 7284
KBio1_001880
KBio2_000410
KBio2_002978
KBio2_005546
KBio3_000779
KBio3_000780
KBioGR_000410
KBioSS_000410
LCP-Siro
LMPK06000003
LS-143290
MLS000028373
MS-R001
MolMap_000043
MolPort-003-959-433
NCGC00021305-05
NCI60_001851
NCIMech_000355
NSC 226080
NSC226080
Perceiva
QTL1_000069
R0395_SIAL
R0395_SIGMA
RAP
RAPA
RPM
Rapammune
Rapamune
Rapamune (TN)
Rapamycin
Rapamycin (TN)
Rapamycin C-7, analog 4
Rapamycin Immunosuppressant Drug
Rapamycin from Streptomyces hygroscopicus
S1039_Selleck
SIIA 9268A
SILA 9268A
SILA9268A
SMP1_000255
SMR000058564
Sirolimus
Sirolimus (RAPAMUNE)
Sirolimus (USAN/INN)
Sirolimus [USAN:BAN:INN]
Sirolimus, Rapamune,Rapamycin
SpecPlus_000840
UNII-W36ZG6FT64
UNM-0000358684
WY-090217
Wy 090217
heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy
nchembio.100-comp4
nchembio.2007.42-comp2
nchembio.79-comp1
nchembio762-comp1
nchembio883-comp3
rapamycin
sirolimus
3
Miconazoleapproved, investigationalPhase 2291222916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
4
PamidronateapprovedPhase 14240391-99-94674
Synonyms:
(3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID
(3-Amino-1-hydroxypropylidene)bisphosphonic acid
(3-Amino-1-hydroxypropylidene)diphosphonic acid
(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
(3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
(3-amino-1-hydroxypropylidene)-1,1-biphosphonate
(3-amino-1-hydroxypropylidene)-1,1-bisphosphonate
1-hydroxy-3-aminopropane-1,1-diphosphonic acid
3-Amino-1-hydroxypropylidene-1,1-diphosphonate
40391-99-9
57248-88-1
57248-88-1 (di-hydrochloride salt)
AC1L1IP4
AHPrBP
AKOS003599275
APD
Acide pamidronique
Acide pamidronique [INN-French]
Acido pamidronico
Acido pamidronico [INN-Spanish]
Acidum pamidronicum
Acidum pamidronicum [INN-Latin]
Amidronate
Aminomux
Aredia
BIDD:GT0538
Bisphosphonate 6
C019248
C07395
C3H11NO7P2
 
CHEMBL834
CID4674
ChemDiv1_025240
D07281
DB00282
EINECS 254-905-2
HMS2090C13
HMS658L06
HSCI1_000312
I14-2407
LS-174826
MolPort-002-131-054
NCGC00159433-02
NCGC00159433-03
Novartis brand of pamidronate disodium salt
PAMIDRONATE DISODIUM
PAMIDRONIC ACID
Pamidronate Disodium
Pamidronic acid
Pamidronic acid (INN)
Pamidronic acid [INN:BAN]
Ribodroat
Ribodroat (TN)
STOCK1N-12562
UNII-OYY3447OMC
amino-1-hydroxypropane-1,1-diphosphonate
aminohydroxypropylidene diphosphonate
aminopropanehydroxydiphosphonate
pamidronate
pamidronate calcium
pamidronate monosodium
5DiphosphonatesPhase 1369
6
Sevelamerapproved69152751-57-03085017
Synonyms:
Renagel
Renvela
Sevelamer
Sevelamer Carbonate
 
Sevelamero
Sevelamerum
Sévélamer
sevelamer carbonate
sevelamer hydrochloride
7
Alfacalcidolapproved, nutraceutical4041294-56-85282181
Synonyms:
(5Z,7e)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol
1-Hydroxycholecalciferol
1-hydroxycholecalciferol
1alpha-Hydroxy-vitamin D3
 
1alpha-hydroxycholecalciferol
1alpha-hydroxyvitamin D3
9,10-Secocholesta-5,7,10(19)-triene-1alpha,3beta-diol
Alfacalcidolum
Alsiodol
8Hydroxycholecalciferols88

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon TransferCompletedNCT00950053Phase 4
2Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K ActivationRecruitingNCT02428296Phase 2
3Autologous Stem Cells in Achilles TendinopathyNot yet recruitingNCT02064062Phase 2
4Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) SyndromeActive, not recruitingNCT02544659Phase 1
5Nottingham Osteoarthritis Biomarker Study 2011CompletedNCT01495455
6Immune Response in the SAPHO SyndromeCompletedNCT01688219
7A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal SpurCompletedNCT01510249
8Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar FasciitisCompletedNCT01439932
9The Health-Related Quality of Life in Patients With Hereditary Multiple ExostosesCompletedNCT00474448
10Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic DiseaseRecruitingNCT02504879
11Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD)RecruitingNCT01630460
12Hypophosphatemic Rickets in NorwayActive, not recruitingNCT01057186
13Clinical Observation Study With the SBG StemActive, not recruitingNCT02338661
14Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal SurgeryEnrolling by invitationNCT00984672
15Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre ProjectSuspendedNCT00474331
16Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BCTerminatedNCT00473850

Search NIH Clinical Center for Hyperostosis


Cochrane evidence based reviews: Hyperostosis

Genetic Tests for Hyperostosis

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Anatomical Context for Hyperostosis

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MalaCards organs/tissues related to Hyperostosis:

33
Bone, Spinal cord, Brain, Testes, Myeloid, Neutrophil, T cells

FMA organs/tissues related to Hyperostosis:

16
Bone

Animal Models for Hyperostosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Hyperostosis:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1ALPL, COL1A1, EXT1, FGF23, FLNA, GALNT3
2MP:00053708.4ANKH, COL1A1, FLNA, LRP5, SQSTM1, TNFRSF11A
3MP:00107718.2COL1A1, EXT1, FGF23, GALNT3, LRP4, SQSTM1
4MP:00053897.9ALPL, ANKH, COL1A1, FGF23, FLNA, GALNT3
5MP:00053827.6ALPL, ANKH, COL1A1, EXT1, FLNA, GALNT3
6MP:00053887.6ALPL, ANKH, COL1A1, COX4I2, FGF23, FLNA
7MP:00053717.4ALPL, ANKH, COL1A1, EXT1, FGF23, GALNT3
8MP:00053977.2ALPL, ANKH, COL1A1, FGF23, FLNA, LRP5
9MP:00053877.1ALPL, ANKH, COL1A1, COX4I2, FGF23, FLNA
10MP:00053866.7ALPL, ANKH, COL1A1, COX4I2, EXT1, FLNA
11MP:00053906.3ALPL, ANKH, COL1A1, EXT1, EXT2, FGF23
12MP:00053786.2ALPL, ANKH, COL1A1, COX4I2, EXT1, FGF23
13MP:00107685.8ALPL, ANKH, COL1A1, EXT1, EXT2, FGF23
14MP:00053765.4ALPL, ANKH, COL1A1, COX4I2, FGF23, FLNA

Publications for Hyperostosis

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Articles related to Hyperostosis:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Cortical hyperostosis as a side-effect of prolonged use of prostaglandins. (26423344)
2015
2
Hyperostosis frontalis interna as a potential source of cerebral oximetry signal interference: A case report. (25906264)
2015
3
An Unusual Bone Metastasis Mimicking SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) Syndrome on Bone Scintigraphy. (26505860)
2015
4
Femoral nerve entrapment in a dog with diffuse idiopathic skeletal hyperostosis. (25651036)
2015
5
Thoracic and lumbar vertebral bone mineral density changes in a natural occurring dog model of diffuse idiopathic skeletal hyperostosis. (25898128)
2015
6
Ultrasonography of peripheral entheses in the diagnosis and understanding of diffuse idiopathic skeletal hyperostosis (DISH). (25503650)
2015
7
Hyperostosis frontalis interna presenting as depression and parkinsonism in an older woman. (26551972)
2015
8
Complications and survival after long posterior instrumentation of cervical and cervicothoracic fractures related to ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis. (25494322)
2015
9
Diffuse idiopathic skeletal hyperostosis (DISH) of the elbow: a controlled radiological study. (25982369)
2015
10
Hyperostosis-hyperphosphatemia syndrome (HHS): report of two cases with a recurrent mutation and review of the literature. (25153226)
2014
11
Disseminated idiopathic skeletal hyperostosis: diagnostic criteria and clinical significance. (24948172)
2014
12
Parosteal lipoma with hyperostosis: case report. (25588291)
2014
13
Avascular necrosis of the hip and diffuse idiopathic skeletal hyperostosis during long-term isotretinoin treatment of epidermolytic ichthyosis due to a novel deletion mutation in KRT10. (24720725)
2014
14
IMAGING DIAGNOSIS-AN ATYPICAL PRESENTATION OF DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (DISH) IN A DOG. (24320791)
2013
15
A case of psoriasis vulgaris with diffuse idiopathic skeletal hyperostosis involved with ossifications of posterior and anterior longitudinal ligament. (20165950)
2012
16
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
17
Diffuse idiopathic skeletal hyperostosis (DISH). (21771167)
2011
18
Etiopathogenesis of hyperostosis frontalis interna: a mystery still. (21684729)
2011
19
Dysphagia caused by diffuse idiopathic skeletal hyperostosis. (21907632)
2011
20
Quantitative analysis of the anterolateral ossification mass in diffuse idiopathic skeletal hyperostosis of the thoracic spine. (21340711)
2011
21
Management of craniofacial hyperostosis in Proteus syndrome. (20216456)
2010
22
Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)
2009
23
Imaging characteristics of diffuse idiopathic skeletal hyperostosis with an emphasis on acute spinal fractures: review. (19696239)
2009
24
A novel missense mutation in GALNT3 causing hyperostosis-hyperphosphataemia syndrome. (18322299)
2008
25
The prevalence of diffuse idiopathic skeletal hyperostosis in an outpatient population in The Netherlands. (18528963)
2008
26
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
27
Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery. (15287538)
2004
28
Parasagittal meningioma en plaque with extracranial extension presenting diffuse massive hyperostosis of the skull. (14751632)
2004
29
Hyperostosis and osteitis in Sapho syndrome: conservative or surgical treatment. (15382585)
2004
30
Spontaneous symptomatic pseudoarthrosis at the T11-T12 intervertebral space with diffuse idiopathic skeletal hyperostosis: a case report. (12923487)
2003
31
Degenerative sternoclavicular arthritis and hyperostosis. (12825539)
2003
32
Sternoclavicular hyperostosis with pathological fracture of the clavicle--a case report. (12767795)
2003
33
Periosteal hyperostosis (exostosis) in DBA/1 male mice. (12051556)
2002
34
Diffuse idiopathic skeletal hyperostosis in a patient with idiopathic retroperitoneal fibrosis: a case report. (12426664)
2002
35
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
36
Hyperextension vertebral body fractures in diffuse idiopathic skeletal hyperostosis: a cause of intravertebral fluidlike collections on MR imaging. (10584819)
1999
37
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
38
Case report. synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. (9161184)
1996
39
Subcutaneous calcifications in diffuse idiopathic skeletal hyperostosis. (7774094)
1995
40
Hyperostosis of ribs: association with vertebral ossification. (8014935)
1993
41
Growth hormone secretion in diffuse idiopathic skeletal hyperostosis. (1524945)
1992
42
Diffuse idiopathic skeletal hyperostosis and situs viscerum inversus. (2585410)
1989
43
Cervical involvement of diffuse idiopathic skeletal hyperostosis with dysphagia and rhinolalia. (3266838)
1988
44
Renal osteodystrophy with facial hyperostosis and 'rubber jaw' in an adult dog. (16031185)
1985
45
Diffuse idiopathic skeletal hyperostosis in a patient with situs inversus. (6860386)
1983
46
An unusual case of diffuse idiopathic skeletal hyperostosis. (6681145)
1983
47
Radiologic aspects of diffuse idiopathic skeletal hyperostosis in the spine. (410264)
1977
48
Infantile cortical hyperostosis of the scapula presenting as an ipsilateral Erb's palsy. (4561478)
1972
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Hypervitaminosis A with infantile cortical hyperostosis. (14850258)
1951

Variations for Hyperostosis

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Expression for genes affiliated with Hyperostosis

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Search GEO for disease gene expression data for Hyperostosis.

Pathways for genes affiliated with Hyperostosis

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Pathways related to Hyperostosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0LRP5, SOST
29.9COL1A1, FGF23

GO Terms for genes affiliated with Hyperostosis

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Cellular components related to Hyperostosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.1ALPL, COL1A1, COL6A1, SOST

Biological processes related to Hyperostosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cellular polysaccharide biosynthetic processGO:003369210.4EXT1, EXT2
2heparan sulfate proteoglycan biosynthetic processGO:001501210.3EXT1, EXT2
3Wnt signaling pathway involved in dorsal/ventral axis specificationGO:004433210.3LRP4, LRP5
4negative regulation of ossificationGO:003027910.1LRP4, SOST
5regulation of canonical Wnt signaling pathwayGO:006082810.0LRP4, LRP5
6receptor clusteringGO:004311310.0FLNA, LRP4
7heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processGO:001501410.0EXT1, EXT2
8protein heterotrimerizationGO:00702089.9COL1A1, COL6A1
9regulation of bone mineralizationGO:00305009.8ANKH, FGF23
10endochondral ossificationGO:00019589.5ALPL, COL1A1
11osteoblast differentiationGO:00016499.3ALPL, COL1A1, COL6A1
12skeletal system developmentGO:00015018.9ALPL, ANKH, COL1A1, EXT1
13ossificationGO:00015038.8COL1A1, EXT1, EXT2, SOST, TNFRSF11A

Molecular functions related to Hyperostosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1heparan sulfate N-acetylglucosaminyltransferase activityGO:004232810.5EXT1, EXT2
2glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityGO:005050810.5EXT1, EXT2
3N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:005050910.5EXT1, EXT2
4acetylglucosaminyltransferase activityGO:000837510.4EXT1, EXT2
5Wnt-activated receptor activityGO:004281310.3LRP4, LRP5
6glucuronosyltransferase activityGO:001502010.1EXT1, EXT2
7Wnt-protein bindingGO:001714710.0LRP4, LRP5
8transferase activity, transferring glycosyl groupsGO:00167579.8EXT1, EXT2, GALNT3
9platelet-derived growth factor bindingGO:00484079.6COL1A1, COL6A1
10protein homodimerization activityGO:00428038.5EXT1, EXT2, FLNA, LRP4, SQSTM1

Sources for Hyperostosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet