MCID: HYP068
MIFTS: 50

Hyperostosis malady

Bone diseases category

Summaries for Hyperostosis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

MalaCards: Hyperostosis, also known as hypertrophy of bone, is related to hyperphosphatemia and calcinosis. An important gene associated with Hyperostosis is LRP5 (low density lipoprotein receptor-related protein 5). The compounds 1,25 dihydroxy vitamin d3 and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and spinal cord, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Disease Ontology:9 A bone remodeling disease that results in an abnormal growth of located in bone.

Aliases & Classifications for Hyperostosis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

hyperostosis 9 11 46 63
hypertrophy of bone 9
bone hypertrophy 9


External Ids:

Disease Ontology9 DOID:205
NCIt41 C34712
SNOMED-CT59 203514008, 13814009
MeSH36 D015576
ICD1026 M89.3

Related Diseases for Hyperostosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Hyperostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1hyperphosphatemia30.6FGF23, GALNT3
2calcinosis30.3FGF23, GALNT3
3hyperphosphatemic familial tumoral calcinosis30.3FGF23, GALNT3
4x-linked hypophosphatemia29.8GALNT3, FGF23
5osteoporosis29.8FGF23, LRP5
6diffuse idiopathic skeletal hyperostosis11.1
7acne10.6
8synovitis10.6
9sapho syndrome10.6
10cervicitis10.6
11dysphagia10.6
12caffey disease10.6
13ankylosing spondylitis10.5
14spondylitis10.5
15meningioma10.4
16hyperostosis corticalis generalisata10.4
17calvarial hyperostosis10.4
18osteomyelitis10.4
19hyperostosis-hyperphosphatemia syndrome10.3
20sost-related sclerosing bone dysplasia10.3
21arthritis10.3
22dysplastic cortical hyperostosis10.2
23morgagni-stewart-morel syndrome10.2
24spondylosis10.2
25spinal stenosis10.2
26hypervitaminosis a10.2
27worth's syndrome10.2
28diabetes mellitus10.2
29periostitis10.2
30hyperostosis corticalis generalisata, benign form of worth with torus palatinus10.2
31exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.2
32x-linked calvarial hyperostosis10.2
33psoriatic arthritis10.1
34enthesopathy10.1
35exostosis10.1
36lipoma10.1
37polyosteolysis/hyperostosis syndrome10.1
38hyperostosis, endosteal10.1
39pseudoarthrosis10.1
40osteoarthritis10.1
41quadriplegia10.1
42camurati-engelmann disease10.1
43craniometaphyseal dysplasia10.1
44aspiration pneumonia10.1
45laryngitis10.1
46pneumonia10.1
47psoriasis10.1
48familial tumoral calcinosis10.1
49osteopathia striata cranial sclerosis10.1
50paget disease, juvenile10.1

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to hyperostosis

Symptoms for Hyperostosis

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Drugs & Therapeutics for Hyperostosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hyperostosis

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Anatomical Context for Hyperostosis

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Hyperostosis:

34
Bone, Spinal cord, Myeloid, Testes, T cells, Skin, Colon, Heart, Cortex, Brain, Eye

FMA organs/tissues related to Hyperostosis:

15
Bone

Animal Models for Hyperostosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hyperostosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.7GALNT3, CYP26C1, LRP5
2MP:00053718.5FGF23, GALNT3, CYP26C1, LRP5
3MP:00053788.5FGF23, GALNT3, COX4I2, LRP5
4MP:00053858.0LRP5, GALNT3, RBP4, FGF23
5MP:00053767.6LRP5, COX4I2, GALNT3, RBP4, FGF23

Publications for Hyperostosis

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Sources:
53PubMed
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Articles related to Hyperostosis:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
IMAGING DIAGNOSIS-AN ATYPICAL PRESENTATION OF DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (DISH) IN A DOG. (24320791)
2013
2
Genetic basis of hyperostosis cranialis interna. (24422132)
2013
3
A case of psoriasis vulgaris with diffuse idiopathic skeletal hyperostosis involved with ossifications of posterior and anterior longitudinal ligament. (20165950)
2012
4
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
5
Diffuse idiopathic skeletal hyperostosis (DISH). (21771167)
2011
6
Etiopathogenesis of hyperostosis frontalis interna: a mystery still. (21684729)
2011
7
Dysphagia caused by diffuse idiopathic skeletal hyperostosis. (21907632)
2011
8
Quantitative analysis of the anterolateral ossification mass in diffuse idiopathic skeletal hyperostosis of the thoracic spine. (21340711)
2011
9
Crico Arytenoid Joint Fixation in Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Case Report. (22754839)
2011
10
Management of craniofacial hyperostosis in Proteus syndrome. (20216456)
2010
11
Phenotypic manifestations and management of hyperostosis cranialis interna, a hereditary bone dysplasia affecting the calvaria and the skull base. (20140965)
2010
12
Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)
2009
13
Imaging characteristics of diffuse idiopathic skeletal hyperostosis with an emphasis on acute spinal fractures: review. (19696239)
2009
14
The management of spinal injuries in patients with ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis: a comparison of treatment methods and clinical outcomes. (19342927)
2009
15
A novel missense mutation in GALNT3 causing hyperostosis-hyperphosphataemia syndrome. (18322299)
2008
16
The prevalence of diffuse idiopathic skeletal hyperostosis in an outpatient population in The Netherlands. (18528963)
2008
17
Atypical presentation of osteomyelitis, discitis, epidural, and iliopsoas abscess in diffuse idiopathic skeletal hyperostosis (DISH) syndrome. (18688200)
2008
18
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
19
A family with diffuse idiopathic skeletal hyperostosis. (16284348)
2005
20
Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery. (15287538)
2004
21
Parasagittal meningioma en plaque with extracranial extension presenting diffuse massive hyperostosis of the skull. (14751632)
2004
22
Hyperostosis and osteitis in Sapho syndrome: conservative or surgical treatment. (15382585)
2004
23
The prevalence of diffuse idiopathic skeletal hyperostosis in Korea. (15468371)
2004
24
Degenerative sternoclavicular arthritis and hyperostosis. (12825539)
2003
25
Sternoclavicular hyperostosis with pathological fracture of the clavicle--a case report. (12767795)
2003
26
A structural chiropractic approach to the management of diffuse idiopathic skeletal hyperostosis. (12704313)
2003
27
Periosteal hyperostosis (exostosis) in DBA/1 male mice. (12051556)
2002
28
Diffuse idiopathic skeletal hyperostosis in a patient with idiopathic retroperitoneal fibrosis: a case report. (12426664)
2002
29
Radiology forum. Quiz case 1. Dysphagia due to diffuse idiopathic skeletal hyperostosis (Forestier disease). (11177023)
2001
30
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
31
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
32
The prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in two large American Midwest metropolitan hospital populations. (9151370)
1997
33
Case report. synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. (9161184)
1996
34
A metabolic syndrome in diffuse idiopathic skeletal hyperostosis. A controlled study. (8730125)
1996
35
Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. (8859238)
1996
36
Sapho syndrome with femoral hyperostosis. Two case-reports. (8789884)
1996
37
Subcutaneous calcifications in diffuse idiopathic skeletal hyperostosis. (7774094)
1995
38
Hyperostosis in meningiomas: MR findings in patients with recurrent meningioma of the sphenoid wings. (8197957)
1994
39
Hyperostosis of ribs: association with vertebral ossification. (8014935)
1993
40
Growth hormone secretion in diffuse idiopathic skeletal hyperostosis. (1524945)
1992
41
Diffuse idiopathic skeletal hyperostosis causing acute thoracic myelopathy: a case report and discussion. (2181336)
1990
42
Diffuse idiopathic skeletal hyperostosis and situs viscerum inversus. (2585410)
1989
43
Cervical involvement of diffuse idiopathic skeletal hyperostosis with dysphagia and rhinolalia. (3266838)
1988
44
Renal osteodystrophy with facial hyperostosis and 'rubber jaw' in an adult dog. (16031185)
1985
45
Diffuse idiopathic skeletal hyperostosis in a patient with situs inversus. (6860386)
1983
46
An unusual case of diffuse idiopathic skeletal hyperostosis. (6681145)
1983
47
Radiologic aspects of diffuse idiopathic skeletal hyperostosis in the spine. (410264)
1977
48
Infantile cortical hyperostosis of the scapula presenting as an ipsilateral Erb's palsy. (4561478)
1972
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Hypervitaminosis A with infantile cortical hyperostosis. (14850258)
1951

Variations for Hyperostosis

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Expression for genes affiliated with Hyperostosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperostosis

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Pathways for genes affiliated with Hyperostosis

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Compounds for genes affiliated with Hyperostosis

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46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank
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Compounds related to Hyperostosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
11,25 dihydroxy vitamin d3469.4FGF23, LRP5
2vitamin d469.4FGF23, LRP5
3phosphorus469.1FGF23, RBP4
4valine468.9RBP4, LRP5
5calcium46 52 25 1211.0LRP5, GALNT3, RBP4, FGF23

GO Terms for genes affiliated with Hyperostosis

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17Gene Ontology
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Biological processes related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidation-reduction processGO:0551149.5COX4I2, CYP26C1
2negative regulation of osteoblast differentiationGO:0456689.3FGF23, LRP5
3embryonic retina morphogenesis in camera-type eyeGO:0600599.2RBP4, LRP5
4anterior/posterior pattern specificationGO:0099529.2CYP26C1, LRP5

Products for genes affiliated with Hyperostosis

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  • Antibodies
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Sources for Hyperostosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet