MCID: HYP068
MIFTS: 56

Hyperostosis malady

Bone diseases category

Summaries for Hyperostosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

MalaCards: Hyperostosis, also known as hypertrophy of bone, is related to diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis. An important gene associated with Hyperostosis is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are Senescence and Autophagy and Osteoblast Signaling. The compounds iplex and mecasermin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and spinal cord, and related mouse phenotypes are respiratory system and skeleton.

Disease Ontology:8 A bone remodeling disease that results in an abnormal growth of located in bone.

Aliases & Classifications for Hyperostosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

hyperostosis 8 10 44 60
hypertrophy of bone 8
bone hypertrophy 8


External Ids:

Disease Ontology8 DOID:205
NCIt39 C34712
SNOMED-CT56 13814009, 203514008
MeSH34 D015576
ICD1025 M89.3

Related Diseases for Hyperostosis

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17GeneCards, 18GeneDecks
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Diseases related to Hyperostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1diffuse idiopathic skeletal hyperostosis31.5COL6A1, CYP26C1, TMTC1
2ankylosing spondylitis30.6HLA-B
3hyperphosphatemia30.5ALPL, FGF23, GALNT3
4sost-related sclerosing bone dysplasia30.4SOST, LRP5
5arthritis30.3HLA-B, PTPN22, ALPL
6calcinosis30.2ALPL, FGF23, GALNT3
7hyperphosphatemic familial tumoral calcinosis30.2GALNT3, FGF23
8diabetes mellitus30.2HLA-B, RBP4, IGFBP3, IGF1, LRP5, PTPN22
9osteoarthritis30.0LRP5, IGF1, IGFBP3, COL1A1, COL10A1
10hypoparathyroidism29.9FGF23
11rheumatoid arthritis29.9PTPN22
12renal osteodystrophy29.9ALPL, FGF23
13hydrocephalus29.9FLNA
14obesity29.9IGF1, IGFBP3, RBP4
15myeloma29.9ALPL, IGF1, HLA-B
16pancreatitis29.7ALPL
17hyperparathyroidism29.7FGF23, ALPL
18deficiency anemia29.7ALPL, HLA-B
19x-linked hypophosphatemia29.7GALNT3, FGF23, ALPL
20osteosclerosis29.7ALPL, LRP5, SOST
21hypercalcemia29.7ALPL, FGF23
22acromegaly29.6IGF1, IGFBP3
23atherosclerosis29.6RBP4, IGF1, FGF23
24osteoporosis29.6COL1A1, SOST, IGFBP3, IGF1, FGF23, LRP5
25sapho syndrome10.6
26acne10.6
27synovitis10.6
28cervicitis10.6
29caffey disease10.5
30spondylitis10.4
31meningioma10.4
32osteomyelitis10.4
33spinal stenosis10.2
34calvarial hyperostosis10.2
35hyperostosis, endosteal10.2
36spondylosis10.1
37hypervitaminosis a10.1
38lipoma10.1
39periostitis10.1
40hyperostosis corticalis generalisata, benign form of worth with torus palatinus10.1
41hyperostosis-hyperphosphatemia syndrome10.1
42hyperostosis corticalis generalisata10.1
43morgagni-stewart-morel syndrome10.1
44exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.1
45pseudoarthrosis10.1
46psoriatic arthritis10.1
47enthesopathy10.1
48exostosis10.1
49dysplastic cortical hyperostosis10.1
50x-linked calvarial hyperostosis10.1

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to hyperostosis

Clinical Features for Hyperostosis

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Drugs & Therapeutics for Hyperostosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hyperostosis

Search CenterWatch for Hyperostosis

Genetic Tests for Hyperostosis

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Anatomical Context for Hyperostosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Hyperostosis:

32
Bone, Spinal cord, Testes, Myeloid, Colon, T cells, Heart, Eye, Brain, Skin, Cortex

FMA organs/tissues related to Hyperostosis:

14
Bone

Animal Models for Hyperostosis or affiliated genes

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Sources:
36MGI
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Publications for Hyperostosis

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50PubMed
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Articles related to Hyperostosis:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
IMAGING DIAGNOSIS-AN ATYPICAL PRESENTATION OF DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (DISH) IN A DOG. (24320791)
2013
2
Diagnosis of hyperostosis of the medial calcaneal tubercle similar to a heel spur. (23536504)
2013
3
Diffuse idiopathic skeletal hyperostosis causing dysphagia in a young patient. (24121586)
2013
4
Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline. (23397374)
2013
5
Bilateral conductive hearing impairment with hyperostosis of the temporal bone: a new finding in Robinow syndrome. (22431878)
2012
6
Does bony hyperostosis in intracranial meningioma signify tumor invasion? A radio-pathologic study. (22406780)
2012
7
Diffuse idiopathic skeletal hyperostosis associated with bexarotene. (21920252)
2011
8
Hyperostosis frontalis interna: criteria for sexing and aging a skeleton. (20652712)
2011
9
Diffuse idiopathic skeletal hyperostosis manifesting as recurrent elbow bursitis. (21719624)
2011
10
Identifying and classifying hyperostosis frontalis interna via computerized tomography. (21046669)
2010
11
Patients with diffuse idiopathic skeletal hyperostosis do not have increased peripheral bone mineral density and geometry. (20156975)
2010
12
Erosive inflammatory pseudotumor of the odontoid process in association with Forestier's disease (diffuse idiopathic skeletal hyperostosis). (19340387)
2009
13
Exercise therapy for patients with diffuse idiopathic skeletal hyperostosis. (17885726)
2008
14
Cervical myelopathy caused by soft-tissue mass in diffuse idiopathic skeletal hyperostosis. (17922151)
2008
15
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
16
Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery. (15287538)
2004
17
Cortical hyperostosis in an infant on prolonged prostaglandin infusion: case report and literature review. (15067299)
2004
18
Hyperostosis frontalis interna: case report and review of literature. (15228235)
2004
19
Sternoclavicular hyperostosis with pathological fracture of the clavicle--a case report. (12767795)
2003
20
Radiological features of long bones in synovitis, acne, pustulosis, hyperostosis, osteitis syndrome and their correlation with pathological findings. (24383833)
2002
21
Intracranial low-grade chondrosarcoma with hyperostosis of the skull: a case report. (11212904)
2000
22
A case report of synovitis, acne, pustulosis, hyperostosis and osteitis syndrome presenting with spondylodiscitis. (10851353)
2000
23
Hyperextension vertebral body fractures in diffuse idiopathic skeletal hyperostosis: a cause of intravertebral fluidlike collections on MR imaging. (10584819)
1999
24
Hyperostosis generalisata with striations of the bones: report of a female case and a review of the literature. (10486016)
1999
25
Localised arteriosclerotic changes in congenital hyperostosis in pigs. (8931301)
1996
26
Simultaneous occurrence of diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis. (8738449)
1996
27
Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. (7562783)
1995
28
Time course of radiologic lesions in spinal hyperostosis: an osteoradiometric study. (8869219)
1995
29
Vertebral hyperostosis and diabetes mellitus: a case-control study. (7794043)
1995
30
Vertebral pseudoarthrosis associated with diffuse idiopathic skeletal hyperostosis. (7939834)
1994
31
Hyperextension injuries of the thoracic spine in diffuse idiopathic skeletal hyperostosis. Report of four cases. (8113258)
1994
32
Periarticular hyperostosis and renal disease in six black lemurs of two family groups. (7852158)
1994
33
Cortical hyperostosis: a complication of prolonged prostaglandin infusion in infants awaiting cardiac transplantation. (8115200)
1994
34
Diffuse idiopathic skeletal hyperostosis can resemble metastases on bone scan. (8403726)
1993
35
Seronegative spondyloarthropathies and diffuse idiopathic skeletal hyperostosis in ancient northern Chile. (8333484)
1993
36
Clinical spectrum of synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome. (8252329)
1993
37
Sternocostoclavicular hyperostosis: its progression and radiological features. A study of 12 cases. (1616334)
1992
38
Two cases of diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis. (1643461)
1992
39
Thoracic spinal cord compression caused by diffuse idiopathic skeletal hyperostosis (DISH). (2394071)
1990
40
Infantile cortical hyperostosis (Caffey disease): ultrastructural and immunohistochemical characterization of the peritrabecular cells. (1724929)
1990
41
The prevalence of diffuse idiopathic skeletal hyperostosis in African blacks. (2322769)
1990
42
Esophageal obstruction secondary to diffuse idiopathic skeletal hyperostosis. (3261010)
1988
43
Coexistence of ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis: another report. (3501468)
1987
44
An unusual case of diffuse idiopathic skeletal hyperostosis. (6681145)
1983
45
Periostitis. A manifestation of venous disease and skeletal hyperostosis. (6630858)
1983
46
Marked hyperinsulinemia after glucose challenge in patients with diffuse idiopathic skeletal hyperostosis. (7035664)
1981
47
Diffuse idiopathic skeletal hyperostosis (DISH) [ankylosing hyperostosis of Forestier and Rotes-Querol]. (341323)
1978
48
Clinical communication: a case of hyperostosis due to hypervitaminosis A in a cat. (5816731)
1969
49
Hyperostosis corticalis generalisata. Report of seven cases. (13924477)
1962
50
Hyperostosis of Skull and Exostosis of the Right Auditory Meatus. (19978112)
1914

Genetic Variations for Hyperostosis

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Expression for genes affiliated with Hyperostosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperostosis

Search GEO for disease gene expression data for Hyperostosis.

Pathways for genes affiliated with Hyperostosis

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Hyperostosis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Hyperostosis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1iplex4410.5IGF1, IGFBP3
2mecasermin44 1111.5IGFBP3, IGF1
3oxandrolone44 1111.4IGF1, IGFBP3
4nandrolone44 2411.4IGF1, IGFBP3
525-hydroxyvitamin d4410.4FGF23, IGF1, IGFBP3
6letrozole44 49 59 1113.4IGFBP3, IGF1, CYP26C1
7n-(4-hydroxyphenyl)retinamide4410.4RBP4, IGFBP3, IGF1
8fructosamine44 2411.3RBP4, IGFBP3
9dehydroepiandrosterone sulfate4410.3RBP4, IGFBP3, IGF1
10ghrp4410.3IGF1, IGFBP3
11octreotide44 59 28 1113.3FGF23, IGF1, IGFBP3
12triiodothyronine4410.3RBP4, IGFBP3, IGF1
13valine4410.2COL1A1, RBP4, IGFBP3, LRP5
14androstenedione44 2411.2IGF1, IGFBP3, RBP4
15dhea4410.2IGF1, IGFBP3, HLA-B
16hexarelin44 2811.1IGFBP3, IGF1
17pegvisomant44 1111.1IGF1, IGFBP3
18alpha tocopherol4410.1RBP4, IGFBP3, IGF1
191,25 dihydroxy vitamin d34410.1COL1A1, IGFBP3, IGF1, FGF23, LRP5
20megestrol acetate4410.0IGFBP3, IGF1
21ribonucleic acid4410.0COL1A1, HLA-B, RBP4, IGFBP3, IGF1
22creatinine4410.0HLA-B, RBP4, IGFBP3, IGF1, FGF23
23serine449.9FGF23, FLNA, RBP4, HLA-B
24aspartate449.9COL1A1, HLA-B, RBP4, IGFBP3, ALPL
25cholesterol44 28 11 2412.8LRP5, IGF1, IGFBP3, RBP4, HLA-B
26pyridostigmine44 1110.8IGFBP3, IGF1
27arginine449.8COL1A1, HLA-B, IGFBP3, IGF1, FGF23, PTPN22
28vitamin d449.7ALPL, LRP5, FGF23, IGF1, IGFBP3, SOST
29cysteine449.7COL6A1, COL1A1, SOST, RBP4, IGFBP3, ALPL
30retinoic acid44 2410.7COL1A1, HLA-B, RBP4, IGFBP3, IGF1, ALPL
31calcium44 49 11 2412.4COL1A1, SOST, GALNT3, HLA-B, RBP4, FLNA

GO Terms for genes affiliated with Hyperostosis

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16Gene Ontology
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Cellular components related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.8IGFBP3, IGF1
2extracellular spaceGO:0056159.2ALPL, FGF23, IGF1, IGFBP3, RBP4, SOST
3extracellular regionGO:0055769.2FGF23, IGF1, IGFBP3, FLNA, RBP4, COL1A1

Biological processes related to Hyperostosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1embryonic retina morphogenesis in camera-type eyeGO:06005910.3RBP4, LRP5
2regulation of canonical Wnt receptor signaling pathwayGO:06082810.2LRP5, KREMEN1
3positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGF1, IGFBP3
4collagen catabolic processGO:03057410.0COL1A1, COL6A1, COL10A1
5skeletal system developmentGO:0015019.9ALPL, IGF1, COL1A1, COL10A1
6positive regulation of transcription, DNA-dependentGO:0458939.9COL1A1, SOST, IGF1, FGF23, LRP5
7extracellular matrix disassemblyGO:0226179.9COL10A1, COL6A1, COL1A1
8protein heterotrimerizationGO:0702089.9COL1A1, COL6A1

Molecular functions related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.2COL1A1, COL6A1

Products for genes affiliated with Hyperostosis

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Sources for Hyperostosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet