MCID: HYP068
MIFTS: 50

Hyperostosis malady

Summaries for Hyperostosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

MalaCards: Hyperostosis, also known as hypertrophy of bone, is related to diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis. An important gene associated with Hyperostosis is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are Senescence and Autophagy and Osteoblast Signaling. The compounds iplex and mecasermin have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are respiratory system and skeleton.

Disease Ontology:8 A bone remodeling disease that results in an abnormal growth of located in bone.

Aliases & Classifications for Hyperostosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

hyperostosis 8 10 45 61
hypertrophy of bone 8
bone hypertrophy 8


External Ids:

Disease Ontology8 DOID:205
NCIt40 C34712
SNOMED-CT57 13814009, 203514008
MeSH35 D015576
ICD1025 M89.3

Related Diseases for Hyperostosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hyperostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1diffuse idiopathic skeletal hyperostosis31.5COL6A1, CYP26C1, TMTC1
2ankylosing spondylitis30.7HLA-B
3hyperphosphatemia30.5ALPL, FGF23, GALNT3
4sost-related sclerosing bone dysplasia30.4SOST, LRP5
5arthritis30.3HLA-B, PTPN22, ALPL
6hyperphosphatemic familial tumoral calcinosis30.2GALNT3, FGF23
7osteoarthritis30.1LRP5, IGF1, IGFBP3, COL1A1, COL10A1
8hypoparathyroidism29.9FGF23
9renal osteodystrophy29.9ALPL, FGF23
10deficiency anemia29.7ALPL, HLA-B
11x-linked hypophosphatemia29.7GALNT3, FGF23, ALPL
12hypercalcemia29.7ALPL, FGF23
13acromegaly29.7IGF1, IGFBP3
14atherosclerosis29.7RBP4, IGF1, FGF23
15osteoporosis29.7COL1A1, SOST, IGFBP3, IGF1, FGF23, LRP5
16sapho syndrome10.6
17acne10.6
18synovitis10.6
19dysphagia10.6
20caffey disease10.6
21spondylitis10.5
22calvarial hyperostosis10.4
23hyperostosis corticalis generalisata10.4
24hyperostosis-hyperphosphatemia syndrome10.4
25hyperostosis, endosteal10.3
26spinal stenosis10.2
27n syndrome10.2
28dysplastic cortical hyperostosis10.2
29spondylosis10.2
30hyperostosis corticalis generalisata, benign form of worth with torus palatinus10.2
31morgagni-stewart-morel syndrome10.2
32exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.2
33synovitis, chronic10.2
34pseudoarthrosis10.1
35psoriatic arthritis10.1
36familial tumoral calcinosis10.1
37polyosteolysis/hyperostosis syndrome10.1
38quadriplegia10.1
39camurati-engelmann disease10.1
40situs inversus10.1
41worth's syndrome10.1
42craniometaphyseal dysplasia10.1
43aspiration pneumonia10.1
44paget disease, juvenile10.1
45osteopathia striata cranial sclerosis10.1
46short stature cranial hyperostosis hepatomegaly10.1
47short stature, cranial hyperostosis, hepatomegaly and diabetes10.1
48back pain10.1
49atlantoaxial subluxation10.1
50osteoporosis-pseudoglioma syndrome10.0LRP5

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to hyperostosis

Clinical Features for Hyperostosis

Drugs & Therapeutics for Hyperostosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hyperostosis

Drug clinical trials:

Search ClinicalTrials for Hyperostosis

Search NIH Clinical Center for Hyperostosis

Search CenterWatch for Hyperostosis

Genetic Tests for Hyperostosis

Anatomical Context for Hyperostosis

Sources:
14FMA
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FMA organs/tissues related to Hyperostosis:

14
Bone

Animal Models for Hyperostosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hyperostosis

Sources:
51PubMed
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Articles related to Hyperostosis:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Neurophysiologic, audiometric and vestibular function tests in patients with hyperostosis cranialis interna. (23622937)
2013
2
IgG4-related intracranial hypertrophic pachymeningitis with skull hyperostosis: a case report. (24053604)
2013
3
Transcortical motor aphasia and unilateral parkinsonism in a case of hyperostosis frontalis. (23589640)
2013
4
Radiology quiz case 2. Recurrent inverted papilloma (IP) with focal hyperostosis in the right maxillary sinus. (23657711)
2013
5
Diffuse idiopathic skeletal hyperostosis: clinical features and pathogenic mechanisms. (24189840)
2013
6
Severe destruction of the temporomandibular joint with complete resorption of the condyle associated with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome. (23664782)
2013
7
Mutations in sFRP1 or sFRP4 are not a common cause of craniotubular hyperostosis. (23044044)
2013
8
Management of craniofacial hyperostosis in Proteus syndrome. (20216456)
2010
9
Multilevel myelopathy associated with pseudohypoparathyroidism simulating diffuse skeletal hyperostosis: a case report and literature review. (20938388)
2010
10
Failed videolaryngoscope intubation in a patient with diffuse idiopathic skeletal hyperostosis and spinal cord injury. (20428989)
2010
11
Imaging characteristics of diffuse idiopathic skeletal hyperostosis with an emphasis on acute spinal fractures: review. (19696239)
2009
12
Facial nerve decompression via middle fossa approach for hyperostosis cranialis interna: a feasible therapeutic approach. (19371457)
2009
13
Chronic neck pain. Diffuse idiopathic skeletal hyperostosis. (19378877)
2009
14
A case of familial tumoral calcinosis/hyperostosis-hyperphosphatemia syndrome due to a compound heterozygous mutation in GALNT3 demonstrating new phenotypic features. (18982401)
2009
15
Progressive and symmetric supraorbital hyperostosis with bony and soft tissue overgrowth in an Ethiopian female: a newly recognized overgrowth syndrome? (18241057)
2008
16
Symptomatic lumbar mobile segment with spinal canal stenosis in a fused spine associated with diffused idiopathic skeletal hyperostosis. (18083638)
2008
17
Hyperostosis frontalis interna in a patient with giant cell arteritis. (18250961)
2008
18
Diffuse idiopathic skeletal hyperostosis may give the typical postural abnormalities of advanced ankylosing spondylitis. (17938137)
2007
19
Hyperostosis in an orbital defect with craniofacial implants and open-field magnets: a clinical report. (17499088)
2007
20
Rapid pain relief and remission of sternocostoclavicular hyperostosis after intravenous ibandronate therapy. (16369904)
2006
21
Hyperostosis and osteitis in Sapho syndrome: conservative or surgical treatment. (15382585)
2004
22
Spontaneous symptomatic pseudoarthrosis at the T11-T12 intervertebral space with diffuse idiopathic skeletal hyperostosis: a case report. (12923487)
2003
23
Diffuse idiopathic skeletal hyperostosis: an uncommon case of dysphagia in an older adult. (14661827)
2003
24
Antenatal onset of cortical hyperostosis (Caffey disease): case report and review. (12884437)
2003
25
Diffuse idiopathic skeletal hyperostosis in a patient with idiopathic retroperitoneal fibrosis: a case report. (12426664)
2002
26
Acupuncture for back pain in a patient with Forestier's disease (diffuse idiopathic skeletal hyperostosis/DISH). (12216596)
2002
27
Infantile cortical hyperostosis. (12466580)
2002
28
Diffuse idiopathic skeletal hyperostosis: musculoskeletal manifestations. (11476536)
2001
29
Diffuse idiopathic skeletal hyperostosis in diabetes mellitus, impaired glucose tolerance and obesity. (11294086)
2000
30
The prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in two large American Midwest metropolitan hospital populations. (9151370)
1997
31
Leukocyte-marrow scintigraphy in hyperostosis frontalis interna. (9255168)
1997
32
Sternocostoclavicular hyperostosis. (9093359)
1997
33
"Ecological" treatment of both colon diverticulitis and associated sternoclavicular hyperostosis. (8913667)
1996
34
Anterior atlantoaxial subluxation in a patient with diffuse idiopathic skeletal hyperostosis. (8856628)
1996
35
Coexistence of diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis in two patients. (7554573)
1995
36
Hyperostosis in meningiomas: MR findings in patients with recurrent meningioma of the sphenoid wings. (8197957)
1994
37
Cervical hyperostosis: a rare cause of dysphagia. Case description and bibliographical survey. (7874543)
1994
38
The acquired hyperostosis syndrome: a little known skeletal disorder with distinctive radiological and clinical features. (8136615)
1993
39
Ossification of the ligamentum teres as a possible mechanism of lateral subluxation in coxopathy associated with ankylosing spinal hyperostosis. (8484699)
1993
40
The prevalence of palpable finger joint nodules in diffuse idiopathic skeletal hyperostosis (DISH). A controlled study. (1643450)
1992
41
Coexisting diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis. (2065518)
1991
42
Diffuse idiopathic skeletal hyperostosis and situs viscerum inversus. (2585410)
1989
43
Case report 363: Infantile cortical hyperostosis (Caffey disease ICH) iliac bones, femora, tibiae and left fibula. (3526563)
1986
44
Diffuse idiopathic skeletal hyperostosis of the cervical spine in a patient with ankylosing spondylitis. (6426481)
1984
45
Hyperostosis frontalis, galactorrhoea/hyperprolactinaemia, and Morgagni-Stewart-Morel syndrome. (6131191)
1983
46
Spinal entheseal new bone formation: the early changes of spinal diffuse idiopathic skeletal hyperostosis. (6420561)
1983
47
Peripheral enthesopathy in diffuse idiopathic skeletal hyperostosis (DISH): a radiologic study. (6813470)
1982
48
Hyperostosis corticalis generalisata familiaris. (4371569)
1974
49
Unilateral osteocardilaginous exostosis osteoma of the mandible and hyperostosis: report of a case. (4500449)
1972
50
Traumatic hyperostosis of orbital bones and exophthalmos. (5154724)
1971

Genetic Variations for Hyperostosis

Expression for genes affiliated with Hyperostosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperostosis

Search GEO for disease gene expression data for Hyperostosis.

Pathways for genes affiliated with Hyperostosis

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Hyperostosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Hyperostosis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1iplex4510.5IGF1, IGFBP3
2mecasermin45 1111.5IGFBP3, IGF1
3oxandrolone45 1111.4IGF1, IGFBP3
4nandrolone45 2411.4IGF1, IGFBP3
525-hydroxyvitamin d4510.4FGF23, IGF1, IGFBP3
6letrozole45 50 60 1113.4IGFBP3, IGF1, CYP26C1
7n-(4-hydroxyphenyl)retinamide4510.4RBP4, IGFBP3, IGF1
8fructosamine45 2411.3RBP4, IGFBP3
9dehydroepiandrosterone sulfate4510.3RBP4, IGFBP3, IGF1
10ghrp4510.3IGF1, IGFBP3
11octreotide45 60 29 1113.3FGF23, IGF1, IGFBP3
12triiodothyronine4510.3RBP4, IGFBP3, IGF1
13valine4510.2COL1A1, RBP4, IGFBP3, LRP5
14androstenedione45 2411.2IGF1, IGFBP3, RBP4
15dhea4510.2IGF1, IGFBP3, HLA-B
16hexarelin45 2911.1IGFBP3, IGF1
17pegvisomant45 1111.1IGF1, IGFBP3
18alpha tocopherol4510.1RBP4, IGFBP3, IGF1
191,25 dihydroxy vitamin d34510.1COL1A1, IGFBP3, IGF1, FGF23, LRP5
20megestrol acetate4510.0IGFBP3, IGF1
21ribonucleic acid4510.0COL1A1, HLA-B, RBP4, IGFBP3, IGF1
22creatinine4510.0HLA-B, RBP4, IGFBP3, IGF1, FGF23
23serine459.9FGF23, FLNA, RBP4, HLA-B
24aspartate459.9COL1A1, HLA-B, RBP4, IGFBP3, ALPL
25cholesterol45 29 11 2412.8LRP5, IGF1, IGFBP3, RBP4, HLA-B
26pyridostigmine45 1110.8IGFBP3, IGF1
27arginine459.8COL1A1, HLA-B, IGFBP3, IGF1, FGF23, PTPN22
28vitamin d459.7ALPL, LRP5, FGF23, IGF1, IGFBP3, SOST
29cysteine459.7COL6A1, COL1A1, SOST, RBP4, IGFBP3, ALPL
30retinoic acid45 2410.7COL1A1, HLA-B, RBP4, IGFBP3, IGF1, ALPL
31calcium45 50 11 2412.4COL1A1, SOST, GALNT3, HLA-B, RBP4, FLNA

GO Terms for genes affiliated with Hyperostosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.8IGF1, IGFBP3
2extracellular spaceGO:0056159.2ALPL, COL1A1, SOST, RBP4, IGFBP3, IGF1
3extracellular regionGO:0055769.2COL10A1, COL6A1, COL1A1, RBP4, FLNA, IGFBP3

Biological processes related to Hyperostosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1embryonic retina morphogenesis in camera-type eyeGO:06005910.3RBP4, LRP5
2regulation of canonical Wnt receptor signaling pathwayGO:06082810.2LRP5, KREMEN1
3positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGF1, IGFBP3
4collagen catabolic processGO:03057410.0COL1A1, COL6A1, COL10A1
5skeletal system developmentGO:0015019.9ALPL, IGF1, COL1A1, COL10A1
6positive regulation of transcription, DNA-dependentGO:0458939.9COL1A1, SOST, IGF1, FGF23, LRP5
7extracellular matrix disassemblyGO:0226179.9COL10A1, COL6A1, COL1A1
8protein heterotrimerizationGO:0702089.9COL1A1, COL6A1

Molecular functions related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.2COL1A1, COL6A1

Products for genes affiliated with Hyperostosis

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Sources for Hyperostosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet