MCID: HYP068
MIFTS: 56

Hyperostosis malady

Bone diseases category

Summaries for Hyperostosis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

MalaCards: Hyperostosis, also known as hypertrophy of bone, is related to diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis. An important gene associated with Hyperostosis is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are Senescence and Autophagy and Osteoblast Signaling. The compounds iplex and mecasermin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and spinal cord, and related mouse phenotypes are respiratory system and skeleton.

Disease Ontology:8 A bone remodeling disease that results in an abnormal growth of located in bone.

Aliases & Classifications for Hyperostosis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

hyperostosis 8 10 44 60
hypertrophy of bone 8
bone hypertrophy 8


External Ids:

Disease Ontology8 DOID:205
NCIt39 C34712
SNOMED-CT56 13814009, 203514008
MeSH34 D015576
ICD1025 M89.3

Related Diseases for Hyperostosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hyperostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1diffuse idiopathic skeletal hyperostosis31.5COL6A1, CYP26C1, TMTC1
2ankylosing spondylitis30.6HLA-B
3hyperphosphatemia30.5ALPL, FGF23, GALNT3
4sost-related sclerosing bone dysplasia30.4SOST, LRP5
5arthritis30.3HLA-B, PTPN22, ALPL
6calcinosis30.2ALPL, FGF23, GALNT3
7hyperphosphatemic familial tumoral calcinosis30.2GALNT3, FGF23
8diabetes mellitus30.2HLA-B, RBP4, IGFBP3, IGF1, LRP5, PTPN22
9osteoarthritis30.0LRP5, IGF1, IGFBP3, COL1A1, COL10A1
10hypoparathyroidism29.9FGF23
11rheumatoid arthritis29.9PTPN22
12renal osteodystrophy29.9ALPL, FGF23
13hydrocephalus29.9FLNA
14obesity29.9IGF1, IGFBP3, RBP4
15myeloma29.9ALPL, IGF1, HLA-B
16pancreatitis29.7ALPL
17hyperparathyroidism29.7FGF23, ALPL
18deficiency anemia29.7ALPL, HLA-B
19x-linked hypophosphatemia29.7GALNT3, FGF23, ALPL
20osteosclerosis29.7ALPL, LRP5, SOST
21hypercalcemia29.7ALPL, FGF23
22acromegaly29.6IGF1, IGFBP3
23atherosclerosis29.6RBP4, IGF1, FGF23
24osteoporosis29.6COL1A1, SOST, IGFBP3, IGF1, FGF23, LRP5
25sapho syndrome10.6
26acne10.6
27synovitis10.6
28cervicitis10.6
29caffey disease10.5
30spondylitis10.4
31meningioma10.4
32osteomyelitis10.4
33spinal stenosis10.2
34calvarial hyperostosis10.2
35hyperostosis, endosteal10.2
36spondylosis10.1
37hypervitaminosis a10.1
38lipoma10.1
39periostitis10.1
40hyperostosis corticalis generalisata, benign form of worth with torus palatinus10.1
41hyperostosis-hyperphosphatemia syndrome10.1
42hyperostosis corticalis generalisata10.1
43morgagni-stewart-morel syndrome10.1
44exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.1
45pseudoarthrosis10.1
46psoriatic arthritis10.1
47enthesopathy10.1
48exostosis10.1
49dysplastic cortical hyperostosis10.1
50x-linked calvarial hyperostosis10.1

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to hyperostosis

Clinical Features for Hyperostosis

About this section

Drugs & Therapeutics for Hyperostosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperostosis

Drug clinical trials:

Search ClinicalTrials for Hyperostosis

Search NIH Clinical Center for Hyperostosis

Search CenterWatch for Hyperostosis

Genetic Tests for Hyperostosis

About this section

Anatomical Context for Hyperostosis

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Hyperostosis:

32
Bone, Spinal cord, Testes, Myeloid, Colon, T cells, Heart, Eye, Brain, Skin, Cortex

FMA organs/tissues related to Hyperostosis:

14
Bone

Animal Models for Hyperostosis or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Hyperostosis

About this section
Sources:
50PubMed
See all sources

Articles related to Hyperostosis:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Skull Parosteal Lipoma with Reactive Hyperostosis: A Case Report. (24162239)
2013
2
Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans. (23184610)
2013
3
I feel it in my bones: a rare presentation of idiopathic sclerosing orbital inflammation with hyperostosis. (22957480)
2013
4
Palmoplantar pustulosis presenting with chest pain. Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. (23715612)
2013
5
A case of psoriasis vulgaris with diffuse idiopathic skeletal hyperostosis involved with ossifications of posterior and anterior longitudinal ligament. (20165950)
2012
6
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas. (22327326)
2012
7
Unusual bridge ossification of pubic symphysis in diffuse idiopathic skeletal hyperostosis. (22057147)
2012
8
Thoracic vertebral body fracture after total hip replacement in diffuse idiopathic skeletal hyperostosis. (22691644)
2012
9
Hyperostosis fronto-parietalis mimicking metastasis to the skull: Unveiled on SPECT/CT. (24019665)
2012
10
A comparison of new bone formation in patients with ankylosing spondylitis and patients with diffuse idiopathic skeletal hyperostosis: a retrospective cohort study over six years. (22042741)
2012
11
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work. (21269311)
2011
12
Diffuse idiopathic skeletal hyperostosis and its relation to back pain among older men: the MrOS Study. (21377195)
2011
13
Case 150: Van Buchem disease (hyperostosis corticalis generalisata). (19789259)
2009
14
The prevalence of diffuse idiopathic skeletal hyperostosis in an outpatient population in The Netherlands. (18528963)
2008
15
Correlation between obesity and female hyperostosis. (19080359)
2008
16
Clinical images: "Melting down" of the cervical spine in a patient with diffuse idiopathic skeletal hyperostosis. (18311832)
2008
17
Diffuse idiopathic skeletal hyperostosis: time for a change. (18322973)
2008
18
Isolated costal hyperostosis: a rare cause of severe hemothorax. (17228217)
2007
19
Hyperostosis with hyperphosphatemia and tumoral calcinosis: a case report. (17437133)
2007
20
Vertebral hyperostosis, ankylosed vertebral fracture and atlantoaxial rotatory subluxation in an elderly patient with a history of infantile idiopathic scoliosis; a case report. (17553141)
2007
21
Cortical hyperostosis secondary to prostaglandin E1 therapy. (17889087)
2007
22
Hyperostosis frontalis interna. (16476822)
2006
23
Giant calvarial hyperostosis with biparasagittal en plaque meningioma. (16804274)
2006
24
Calcium deposition and associated chronic diseases (atherosclerosis, diffuse idiopathic skeletal hyperostosis, and others). (16716887)
2006
25
Brief communication: unusual finding at Pueblo Bonito: multiple cases of hyperostosis frontalis interna. (16444722)
2006
26
Aggressive cranial vault decompression for cranial hyperostosis: technical case report of two cases. (15987595)
2005
27
Dysphonia and cervical hyperostosis: a case report. (14725136)
2003
28
Retro-odontoid pseudotumor in diffuse idiopathic skeletal hyperostosis. (12004188)
2002
29
Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH). (11897552)
2002
30
Clinical manifestations of diffuse idiopathic skeletal hyperostosis of the cervical spine. (12430101)
2002
31
Prevalence of diffuse idiopathic skeletal hyperostosis in Budapest, Hungary. (12422014)
2002
32
A case of infantile cortical hyperostosis. (11598632)
2001
33
Intervertebral disc lesions in diffuse idiopathic skeletal hyperostosis (DISH). (11407085)
2001
34
Images in rheumatology: cervical septic spondylodiscitis in association with diffuse idiopathic skeletal hyperostosis. (10606391)
1999
35
Diffuse idiopathic skeletal hyperostosis in the cervical spine. (10078128)
1999
36
Aspiration pneumonia secondary to giant cervical osteophyte formation (diffuse idiopathic skeletal hyperostosis or Forrestier's disease): a case report. (9824035)
1998
37
About a mandibular hyperostosis: the torus mandibularis. (9060116)
1997
38
Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. (8859238)
1996
39
Subcutaneous calcifications in diffuse idiopathic skeletal hyperostosis. (7774094)
1995
40
Pustular vasculitis with clinical feature of pustular psoriasis and sternoclavicular hyperostosis. (8453151)
1993
41
Parosteal lipoma with hyperostosis: report of two pathologically proven cases evaluated by magnetic resonance imaging. (8348358)
1993
42
'Bull's eye' appearance of hyperostosis frontalis interna. (1638851)
1992
43
Long term follow-up of diffuse idiopathic skeletal hyperostosis in the cervical spine. Analysis of progression of ossification. (1749474)
1991
44
Diffuse idiopathic skeletal hyperostosis causing acute thoracic myelopathy: a case report and discussion. (2181336)
1990
45
Diffuse idiopathic skeletal hyperostosis (DISH) of the spine: a risk factor after hip joint replacement? (2306578)
1990
46
Spondylosis in sand rats: a model of intervertebral disc degeneration and hyperostosis. (2182801)
1990
47
Ossification of the plantar fascia and peroneus longus tendons in diffuse idiopathic skeletal hyperostosis (DISH). (3084776)
1986
48
Spondylosis deformans and diffuse idiopathic skeletal hyperostosis (DISH) in Finland. (7291953)
1981
49
Van Buchem's disease (hyperostosis corticalis generalisata) (181111)
1976
50
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970

Genetic Variations for Hyperostosis

About this section

Expression for genes affiliated with Hyperostosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperostosis

Search GEO for disease gene expression data for Hyperostosis.

Pathways for genes affiliated with Hyperostosis

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN
See all sources

Compounds for genes affiliated with Hyperostosis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Hyperostosis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1iplex4410.5IGF1, IGFBP3
2mecasermin44 1111.5IGFBP3, IGF1
3oxandrolone44 1111.4IGF1, IGFBP3
4nandrolone44 2411.4IGF1, IGFBP3
525-hydroxyvitamin d4410.4FGF23, IGF1, IGFBP3
6letrozole44 49 59 1113.4IGFBP3, IGF1, CYP26C1
7n-(4-hydroxyphenyl)retinamide4410.4RBP4, IGFBP3, IGF1
8fructosamine44 2411.3RBP4, IGFBP3
9dehydroepiandrosterone sulfate4410.3RBP4, IGFBP3, IGF1
10ghrp4410.3IGF1, IGFBP3
11octreotide44 59 28 1113.3FGF23, IGF1, IGFBP3
12triiodothyronine4410.3RBP4, IGFBP3, IGF1
13valine4410.2COL1A1, RBP4, IGFBP3, LRP5
14androstenedione44 2411.2IGF1, IGFBP3, RBP4
15dhea4410.2IGF1, IGFBP3, HLA-B
16hexarelin44 2811.1IGFBP3, IGF1
17pegvisomant44 1111.1IGF1, IGFBP3
18alpha tocopherol4410.1RBP4, IGFBP3, IGF1
191,25 dihydroxy vitamin d34410.1COL1A1, IGFBP3, IGF1, FGF23, LRP5
20megestrol acetate4410.0IGFBP3, IGF1
21ribonucleic acid4410.0COL1A1, HLA-B, RBP4, IGFBP3, IGF1
22creatinine4410.0HLA-B, RBP4, IGFBP3, IGF1, FGF23
23serine449.9FGF23, FLNA, RBP4, HLA-B
24aspartate449.9COL1A1, HLA-B, RBP4, IGFBP3, ALPL
25cholesterol44 28 11 2412.8LRP5, IGF1, IGFBP3, RBP4, HLA-B
26pyridostigmine44 1110.8IGFBP3, IGF1
27arginine449.8COL1A1, HLA-B, IGFBP3, IGF1, FGF23, PTPN22
28vitamin d449.7ALPL, LRP5, FGF23, IGF1, IGFBP3, SOST
29cysteine449.7COL6A1, COL1A1, SOST, RBP4, IGFBP3, ALPL
30retinoic acid44 2410.7COL1A1, HLA-B, RBP4, IGFBP3, IGF1, ALPL
31calcium44 49 11 2412.4COL1A1, SOST, GALNT3, HLA-B, RBP4, FLNA

GO Terms for genes affiliated with Hyperostosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.8IGFBP3, IGF1
2extracellular spaceGO:0056159.2ALPL, FGF23, IGF1, IGFBP3, RBP4, SOST
3extracellular regionGO:0055769.2FGF23, IGF1, IGFBP3, FLNA, RBP4, COL1A1

Biological processes related to Hyperostosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1embryonic retina morphogenesis in camera-type eyeGO:06005910.3RBP4, LRP5
2regulation of canonical Wnt receptor signaling pathwayGO:06082810.2LRP5, KREMEN1
3positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGF1, IGFBP3
4collagen catabolic processGO:03057410.0COL1A1, COL6A1, COL10A1
5skeletal system developmentGO:0015019.9ALPL, IGF1, COL1A1, COL10A1
6positive regulation of transcription, DNA-dependentGO:0458939.9COL1A1, SOST, IGF1, FGF23, LRP5
7extracellular matrix disassemblyGO:0226179.9COL10A1, COL6A1, COL1A1
8protein heterotrimerizationGO:0702089.9COL1A1, COL6A1

Molecular functions related to Hyperostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.2COL1A1, COL6A1

Products for genes affiliated with Hyperostosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperostosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet