Aliases & Classifications for Hyperostosis

MalaCards integrated aliases for Hyperostosis:

Name: Hyperostosis 12 28 51 41 14 69
Hypertrophy of Bone 12
Bone Hypertrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:205
ICD10 32 M89.3 M89.30
MeSH 41 D015576
NCIt 46 C34712
SNOMED-CT 64 13814009 203514008
UMLS 69 C0020492

Summaries for Hyperostosis

Disease Ontology : 12 A bone remodeling disease that results in an abnormal growth of located in bone.

MalaCards based summary : Hyperostosis, also known as hypertrophy of bone, is related to tumoral calcinosis, hyperphosphatemic, familial and osteopathia striata with cranial sclerosis. An important gene associated with Hyperostosis is SOST (Sclerostin), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and spinal cord, and related phenotypes are growth/size/body region and cellular

Wikipedia : 72 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

Related Diseases for Hyperostosis

Diseases related to Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 tumoral calcinosis, hyperphosphatemic, familial 33.5 FGF23 GALNT3 KL
2 osteopathia striata with cranial sclerosis 33.1 LRP5 TNFRSF11B
3 sclerosteosis 32.7 COL1A1 LRP4 LRP5 SOST
4 van buchem disease 32.6 COL1A1 KREMEN1 LRP4 LRP5 SOST
5 craniodiaphyseal dysplasia 32.4 LRP5 SOST TGFB1
6 hyperphosphatemia 30.5 FGF23 GALNT3 KL
7 familial tumoral calcinosis 30.2 FGF23 GALNT3 KL
8 calcinosis 30.0 ANKH FGF23 GALNT3 KL
9 renal osteodystrophy 29.9 FGF23 SOST TNFRSF11B
10 cohen-gibson syndrome 29.8 FGF23 TNFRSF11B
11 facial paralysis 29.6 ANKH LRP5 TGFB1
12 hydrocephalus 28.5 FLNA IGF1 TGFB1
13 osteoporosis 27.9 COL1A1 FGF23 IGF1 KL LRP5 SOST
14 diffuse idiopathic skeletal hyperostosis 12.5
15 hyperostosis frontalis interna 12.4
16 ankylosing vertebral hyperostosis with tylosis 12.3
17 hyperostosis cranialis interna 12.3
18 endosteal hyperostosis, autosomal dominant 12.3
19 calvarial hyperostosis 12.2
20 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.2
21 caffey disease 12.1
22 polyosteolysis-hyperostosis syndrome 12.0
23 dysplastic cortical hyperostosis 12.0
24 sapho syndrome 11.9
25 sclerosteosis 1 11.8
26 short stature cranial hyperostosis hepatomegaly 11.8
27 short stature, cranial hyperostosis, hepatomegaly and diabetes 11.8
28 isolated sternocostoclavicular hyperostosis 11.8
29 paget disease of bone 5, juvenile-onset 11.7
30 camurati-engelmann disease 11.5
31 craniometaphyseal dysplasia, autosomal dominant 11.3
32 sclerosteosis 2 11.1
33 exostosis 11.1
34 lenz-majewski hyperostotic dwarfism 11.0
35 frontometaphyseal dysplasia 2 11.0
36 weleber hecht bigley syndrome 11.0
37 craniodiaphyseal dysplasia, autosomal dominant 10.9
38 craniometaphyseal dysplasia, autosomal recessive 10.9
39 melorheostosis, isolated 10.8
40 buschke-ollendorff syndrome 10.8
41 raine syndrome 10.8
42 ossification of the posterior longitudinal ligament of spine 10.8
43 mass syndrome 10.5 LRP5 SOST
44 bone inflammation disease 10.4
45 synovitis 10.4
46 kummell's disease 10.4 SOST TNFRSF11B
47 cervicitis 10.4
48 dysphagia 10.4
49 tracheal calcification 10.4 FGF23 KL
50 hypophosphatemic rickets, autosomal dominant 10.3 FGF23 GALNT3

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to Hyperostosis

Symptoms & Phenotypes for Hyperostosis

MGI Mouse Phenotypes related to Hyperostosis:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 IGF1 FLNA GALNT3 KL ANKH COX4I2
2 cellular MP:0005384 10.35 IGF1 FLNA GALNT3 ANKH EXT1 COL1A1
3 homeostasis/metabolism MP:0005376 10.29 IGF1 FLNA GALNT3 ANKH COX4I2 COL1A1
4 cardiovascular system MP:0005385 10.27 IGF1 FLNA FGF23 GALNT3 ANKH COL1A1
5 craniofacial MP:0005382 10.26 FLNA GALNT3 KL ANKH EXT1 COL1A1
6 behavior/neurological MP:0005386 10.24 FLNA COL1A1 COX4I2 ANKH EXT1 LRP4
7 immune system MP:0005387 10.2 IGF1 FLNA GALNT3 FGF23 COX4I2 ANKH
8 hematopoietic system MP:0005397 10.19 IGF1 FLNA GALNT3 FGF23 ANKH COL1A1
9 limbs/digits/tail MP:0005371 10.18 IGF1 GALNT3 KL ANKH EXT1 COL1A1
10 mortality/aging MP:0010768 10.15 IGF1 FLNA FGF23 ANKH EXT1 COL1A1
11 endocrine/exocrine gland MP:0005379 10.14 GALNT3 FGF23 IGF1 COL1A1 LRP4 KL
12 digestive/alimentary MP:0005381 10.09 GALNT3 FGF23 FLNA COL1A1 EXT1 KL
13 integument MP:0010771 10.03 GALNT3 FGF23 IGF1 COL1A1 EXT1 LRP4
14 hearing/vestibular/ear MP:0005377 9.99 IGF1 COL1A1 ANKH EXT1 KL TNFRSF11B
15 nervous system MP:0003631 9.97 FLNA IGF1 COL1A1 EXT1 LRP4 KL
16 reproductive system MP:0005389 9.85 IGF1 FLNA GALNT3 FGF23 ANKH COL1A1
17 renal/urinary system MP:0005367 9.8 GALNT3 FGF23 IGF1 COL1A1 LRP4 KL
18 respiratory system MP:0005388 9.61 IGF1 FLNA KL ANKH COX4I2 COL1A1
19 skeleton MP:0005390 9.47 FLNA IGF1 GALNT3 KL ANKH EXT1

Drugs & Therapeutics for Hyperostosis

Drugs for Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
4 Anti-Bacterial Agents Phase 2
5 Antibiotics, Antitubercular Phase 2
6 Antifungal Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Immunosuppressive Agents Phase 2
9
Pamidronate Approved Phase 1 40391-99-9 4674
10 Bone Density Conservation Agents Phase 1
11 Diphosphonates Phase 1
12
Sevelamer Approved 52757-95-6, 152751-57-0 3085017
13
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
14 Analgesics
15 Peripheral Nervous System Agents
16 Chelating Agents
17 Hydroxycholecalciferols
18 Micronutrients
19 Trace Elements
20 Vitamins
21 insulin
22 Insulin, Globin Zinc

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
2 Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation Completed NCT02428296 Phase 2 Sirolimus
3 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
4 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
5 An Efficacy and Safety Study of Palovarotene for the Treatment of MO Not yet recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
6 Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome Completed NCT02544659 Phase 1 pamidronate disodium
7 Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal Surgery Unknown status NCT00984672
8 Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis Completed NCT01417455
9 Nottingham Osteoarthritis Biomarker Study 2011 Completed NCT01495455
10 Immune Response in the SAPHO Syndrome Completed NCT01688219
11 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
12 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
13 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932
14 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
15 Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease Recruiting NCT02504879
16 Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD) Recruiting NCT01630460
17 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100
18 Hypophosphatemic Rickets in Norway Active, not recruiting NCT01057186 Sevelamer
19 Clinical Observation Study With the SBG Stem Active, not recruiting NCT02338661
20 Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Not yet recruiting NCT03237455
21 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
22 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Hyperostosis

Cochrane evidence based reviews: hyperostosis

Genetic Tests for Hyperostosis

Genetic tests related to Hyperostosis:

# Genetic test Affiliating Genes
1 Hyperostosis 28

Anatomical Context for Hyperostosis

The Foundational Model of Anatomy Ontology organs/tissues related to Hyperostosis:

18
Bone

MalaCards organs/tissues related to Hyperostosis:

38
Bone, Spinal Cord, Brain, Myeloid, Testes, Lung, T Cells

Publications for Hyperostosis

Articles related to Hyperostosis:

(show top 50) (show all 789)
# Title Authors Year
1
A frontal sinus osteoma accompanied by an intracranial mucocele and local hyperostosis frontalis interna. ( 29452329 )
2018
2
Images in Neuroscience: Calvarial hyperostosis associated with multiple intracranial tumours. ( 29428264 )
2018
3
Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. ( 29327302 )
2018
4
The surgical management of dysphagia secondary to diffuse idiopathic skeletal hyperostosis. ( 29438856 )
2018
5
Imaging findings suggestive of axial spondyloarthritis in diffuse idiopathic skeletal hyperostosis. ( 28371491 )
2017
6
Treatment-Refractory Sternocostoclavicular Hyperostosis. ( 28751466 )
2017
7
Diffuse idiopathic skeletal hyperostosis (DISH): an unusual cause of airway obstruction. ( 28298382 )
2017
8
Correction: Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next. ( 29177083 )
2017
9
Hyperostosis Frontalis Interna in Myotonic Dystrophy. ( 28824073 )
2017
10
New evidence suggesting a dissociated etiology for cribra orbitalia and porotic hyperostosis. ( 28594081 )
2017
11
Odontoid Fracture in a Patient With Diffuse Idiopathic Skeletal Hyperostosis. ( 28255505 )
2017
12
Swallowing disorders among patients with diffuse idiopathic skeletal hyperostosis. ( 28084872 )
2017
13
Sternocostoclavicular Hyperostosis: An Insufficiently Recognized Clinical Entity. ( 28469489 )
2017
14
Hyperostosis Frontalis Interna in a Child With Severe Traumatic Brain Injury. ( 28503629 )
2017
15
Prevalence of thoracic diffuse idiopathic skeletal hyperostosis (DISH) in Japanese: Results of chest CT-based cross-sectional study. ( 27697426 )
2017
16
Diffuse idiopathic skeletal hyperostosis (DISH): Increased prevalence in Pacific Islanders. ( 29024571 )
2017
17
Skeletal Hyperostosis as a Cause of Aspiration. ( 29122103 )
2017
18
Classification criteria for diffuse idiopathic skeletal hyperostosis: a lack of consensus. ( 28371859 )
2017
19
Diffuse idiopathic skeletal hyperostosis (DISH) - A common but less known cause of back pain. ( 28721001 )
2017
20
Frontal Hyperostosis in the Patients of Craniosynostosis After Cranial Distraction Osteogenesis. ( 28938316 )
2017
21
Diffuse Idiopathic Skeletal Hyperostosis Involving Cervical and Lumbar Spine Presenting with Dysphagia: A Case Report. ( 28819624 )
2017
22
CT-based morphological analysis of spinal fractures in patients with diffuse idiopathic skeletal hyperostosis. ( 27713008 )
2017
23
Diffuse idiopathic skeletal hyperostosis: Can we identify a peripheral pattern? ( 28528871 )
2017
24
SAPHO Syndrome: Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. ( 28250311 )
2017
25
Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. ( 29276872 )
2017
26
Cervical diffuse idiopathic skeletal hyperostosis (DISH) causing oropharyngeal dysphagia. ( 28314808 )
2017
27
Birth Order and Maternal Age for Reported Cases of Severe Prenatal Cortical Hyperostosis (Caffey?Silverman Disease). ( 29142783 )
2017
28
Thoracic spondylolisthesis and spinal cord compression in diffuse idiopathic skeletal hyperostosis: a case report. ( 28363281 )
2017
29
Diffuse idiopathic skeletal hyperostosis causing L4 and L5 nerve root entrapment. ( 28941276 )
2017
30
A rare case of Eagle syndrome and diffuse idiopathic skeletal hyperostosis in the cervical spine. ( 28928500 )
2017
31
Diffuse Idiopathic Skeletal Hyperostosis: Persistent Sore Throat and Dysphagia in an Elderly Smoker Male. ( 29062363 )
2017
32
A Case of Atypical Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) Syndrome Presenting With Osteomyelitis of the Clavicle. ( 29323824 )
2017
33
Delayed leg paraplegia associated with hyperextension injury in patients with diffuse idiopathic skeletal hyperostosis (DISH): case report and review of the literature. ( 28458848 )
2017
34
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. ( 28924111 )
2017
35
Morphological characteristics of diffuse idiopathic skeletal hyperostosis in the cervical spine. ( 29155874 )
2017
36
Relationship between diffuse idiopathic skeletal hyperostosis, abdominal aortic calcification and associated metabolic disorders: Data from the Camargo Cohort. ( 28283270 )
2017
37
Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia. ( 28973168 )
2017
38
Magnetic resonance imaging in diffuse idiopathic skeletal hyperostosis: similarities to axial spondyloarthritis. ( 28364275 )
2017
39
A rare association of dysphagia and cervical compressive myelopathy in diffuse idiopathic skeletal hyperostosis. ( 28084279 )
2017
40
Bony Hyperostosis Recurrence after Complete Resection of Sphenoorbital Meningioma. ( 28989829 )
2017
41
Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. ( 28369706 )
2017
42
Spinal fracture in diffuse idiopathic skeletal hyperostosis. ( 28986210 )
2017
43
Spinal Epidural Hematoma Related to Vertebral Fracture in an Atypical Rigid Diffuse Idiopathic Skeletal Hyperostosis: A Case Report. ( 28255506 )
2017
44
A case of bronchiolitis obliterans organising pneumonia associated with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. ( 28765183 )
2017
45
Diffuse Idiopathic Skeletal Hyperostosis (DISH) as a Cause of Failure Following Distal Clavicle Excision A Case Report and Review of the Literature. ( 29151015 )
2017
46
Transorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases. ( 28862553 )
2017
47
Diffuse idiopathic skeletal hyperostosis with cervical myelopathy. ( 28385821 )
2017
48
Diffuse idiopathic hyperostosis manifesting as dysphagia and bilateral cord paralysis: A case report and literature review. ( 29269071 )
2017
49
Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next. ( 28955488 )
2017
50
Styloid Process Elongation on Cervical Spine Computed Tomography is Associated with the Enthesopathy-Related Diseases of Ankylosing Spondylitis and Diffuse Idiopathic Skeletal Hyperostosis. ( 29185278 )
2017

Variations for Hyperostosis

Expression for Hyperostosis

Search GEO for disease gene expression data for Hyperostosis.

Pathways for Hyperostosis

GO Terms for Hyperostosis

Cellular components related to Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 COL1A1 FGF23 IGF1 KL SOST TGFB1
2 extracellular matrix GO:0031012 9.46 COL1A1 FLNA SOST TGFB1
3 proteinaceous extracellular matrix GO:0005578 9.26 COL1A1 SOST TGFB1 TNFRSF11B
4 extracellular region GO:0005576 9.23 COL1A1 FGF23 FLNA IGF1 KL SOST

Biological processes related to Hyperostosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.8 FGF23 IGF1 KL TGFB1 TNFRSF11B
2 positive regulation of protein kinase B signaling GO:0051897 9.77 FGF23 KL TGFB1
3 platelet degranulation GO:0002576 9.73 FLNA IGF1 TGFB1
4 Wnt signaling pathway GO:0016055 9.73 KREMEN1 LRP4 LRP5 SOST
5 positive regulation of transcription, DNA-templated GO:0045893 9.73 COL1A1 FGF23 IGF1 LRP5 SOST TGFB1
6 ossification GO:0001503 9.69 COL1A1 EXT1 SOST
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 IGF1 LRP4 TGFB1
8 fibroblast growth factor receptor signaling pathway GO:0008543 9.65 FGF23 GALNT3 KL
9 positive regulation of mitotic nuclear division GO:0045840 9.59 IGF1 LRP5
10 receptor clustering GO:0043113 9.58 FLNA LRP4
11 regulation of bone mineralization GO:0030500 9.58 ANKH FGF23
12 phosphate-containing compound metabolic process GO:0006796 9.57 FGF23 TGFB1
13 positive regulation of transcription regulatory region DNA binding GO:2000679 9.55 IGF1 TGFB1
14 cell activation GO:0001775 9.54 IGF1 TGFB1
15 response to magnesium ion GO:0032026 9.52 FGF23 TNFRSF11B
16 cellular response to parathyroid hormone stimulus GO:0071374 9.46 FGF23 SOST
17 Wnt signaling pathway involved in dorsal/ventral axis specification GO:0044332 9.37 LRP4 LRP5
18 skeletal system development GO:0001501 9.35 ANKH COL1A1 EXT1 IGF1 TNFRSF11B
19 regulation of canonical Wnt signaling pathway GO:0060828 9.33 KREMEN1 LRP4 LRP5
20 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.32 FGF23 KL
21 negative regulation of ossification GO:0030279 8.92 KREMEN1 LRP4 SOST TGFB1

Molecular functions related to Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor binding GO:0005104 8.96 FGF23 KL
2 Wnt-activated receptor activity GO:0042813 8.62 LRP4 LRP5

Sources for Hyperostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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