Aliases & Classifications for Hyperostosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 25ICD10
See all sources

Hyperostosis, Aliases & Descriptions:

Name: Hyperostosis 9 11 43 60
Hypertrophy of Bone 9
 
Bone Hypertrophy 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:205
MeSH33 D015576
SNOMED-CT55 203514008, 13814009
NCIt38 C34712
ICD1025 M89.3

Summaries for Hyperostosis

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Wikipedia:63 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

MalaCards based summary: Hyperostosis, also known as hypertrophy of bone, is related to hyperphosphatemia and tumoral calcinosis, hyperphosphatemic, familial. An important gene associated with Hyperostosis is LRP5 (low density lipoprotein receptor-related protein 5). The compounds 1,25 dihydroxy vitamin d3 and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and spinal cord, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Disease Ontology:9 A bone remodeling disease that results in an abnormal growth of located in bone.

Related Diseases for Hyperostosis

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Diseases related to Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1hyperphosphatemia30.7FGF23, GALNT3
2tumoral calcinosis, hyperphosphatemic, familial30.5FGF23, GALNT3
3calcinosis30.4FGF23, GALNT3
4familial tumoral calcinosis30.4FGF23, GALNT3
5hypophosphatemic rickets, x-linked dominant30.1GALNT3, FGF23
6osteoporosis29.8FGF23, LRP5
7diffuse idiopathic skeletal hyperostosis11.1
8acne10.7
9sapho syndrome10.7
10synovitis10.7
11dysphagia10.7
12cervicitis10.7
13caffey disease10.6
14spondylitis10.5
15calvarial hyperostosis10.5
16osteomyelitis10.4
17hyperostosis, endosteal10.4
18van buchem disease10.4
19sclerosteosis10.3
20exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.3
21arthritis10.3
22spondylosis10.3
23lipoma10.2
24proteus syndrome, somatic10.2
25morgagni-stewart-morel syndrome10.2
26spinal stenosis10.2
27hypervitaminosis a10.2
28periostitis10.2
29polyosteolysis/hyperostosis syndrome10.2
30x-linked calvarial hyperostosis10.2
31oculodentodigital dysplasia10.1
32paget disease, juvenile10.1
33camurati-engelmann disease10.1
34osteopathia striata with cranial sclerosis10.1
35craniometaphyseal dysplasia10.1
36psoriatic arthritis10.1
37ghosal hematodiaphyseal syndrome10.1
38osteoarthritis10.1
39pseudoarthrosis10.1
40diffuse scleroderma10.1
41enthesopathy10.1
42exostosis10.1
43sost-related sclerosing bone dysplasia10.1
44short stature cranial hyperostosis hepatomegaly10.1
45short stature, cranial hyperostosis, hepatomegaly and diabetes10.1
46lenz-majewski hyperostotic dwarfism10.1
47buschke-ollendorff syndrome10.1
48quadriplegia10.1
49craniodiaphyseal dysplasia10.1
50worth's syndrome10.1

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to hyperostosis

Symptoms for Hyperostosis

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Drugs & Therapeutics for Hyperostosis

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Drug clinical trials:

Search ClinicalTrials for Hyperostosis

Search NIH Clinical Center for Hyperostosis

Genetic Tests for Hyperostosis

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Anatomical Context for Hyperostosis

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MalaCards organs/tissues related to Hyperostosis:

31
Bone, Spinal cord, Brain, Testes, Myeloid, Eye, Cortex, Heart, Colon, Skin, T cells, Neutrophil

FMA organs/tissues related to Hyperostosis:

14
Bone

Animal Models for Hyperostosis or affiliated genes

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MGI Mouse Phenotypes related to Hyperostosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.7GALNT3, CYP26C1, LRP5
2MP:00053718.5FGF23, GALNT3, CYP26C1, LRP5
3MP:00053788.5FGF23, GALNT3, COX4I2, LRP5
4MP:00053858.0LRP5, GALNT3, RBP4, FGF23
5MP:00053767.6LRP5, COX4I2, GALNT3, RBP4, FGF23

Publications for Hyperostosis

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Articles related to Hyperostosis:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Hyperostosis frontalis interna as a potential source of cerebral oximetry signal interference: A case report. (25906264)
2015
2
Femoral nerve entrapment in a dog with diffuse idiopathic skeletal hyperostosis. (25651036)
2015
3
Thoracic and lumbar vertebral bone mineral density changes in a natural occurring dog model of diffuse idiopathic skeletal hyperostosis. (25898128)
2015
4
Ultrasonography of peripheral entheses in the diagnosis and understanding of diffuse idiopathic skeletal hyperostosis (DISH). (25503650)
2015
5
Complications and survival after long posterior instrumentation of cervical and cervicothoracic fractures related to ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis. (25494322)
2015
6
Hyperostosis-hyperphosphatemia syndrome (HHS): report of two cases with a recurrent mutation and review of the literature. (25153226)
2014
7
Disseminated idiopathic skeletal hyperostosis: diagnostic criteria and clinical significance. (24948172)
2014
8
Parosteal lipoma with hyperostosis: case report. (25588291)
2014
9
Avascular necrosis of the hip and diffuse idiopathic skeletal hyperostosis during long-term isotretinoin treatment of epidermolytic ichthyosis due to a novel deletion mutation in KRT10. (24720725)
2014
10
IMAGING DIAGNOSIS-AN ATYPICAL PRESENTATION OF DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (DISH) IN A DOG. (24320791)
2013
11
A case of psoriasis vulgaris with diffuse idiopathic skeletal hyperostosis involved with ossifications of posterior and anterior longitudinal ligament. (20165950)
2012
12
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
13
Diffuse idiopathic skeletal hyperostosis (DISH). (21771167)
2011
14
Etiopathogenesis of hyperostosis frontalis interna: a mystery still. (21684729)
2011
15
Dysphagia caused by diffuse idiopathic skeletal hyperostosis. (21907632)
2011
16
Quantitative analysis of the anterolateral ossification mass in diffuse idiopathic skeletal hyperostosis of the thoracic spine. (21340711)
2011
17
Management of craniofacial hyperostosis in Proteus syndrome. (20216456)
2010
18
Phenotypic manifestations and management of hyperostosis cranialis interna, a hereditary bone dysplasia affecting the calvaria and the skull base. (20140965)
2010
19
Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)
2009
20
Imaging characteristics of diffuse idiopathic skeletal hyperostosis with an emphasis on acute spinal fractures: review. (19696239)
2009
21
The management of spinal injuries in patients with ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis: a comparison of treatment methods and clinical outcomes. (19342927)
2009
22
A novel missense mutation in GALNT3 causing hyperostosis-hyperphosphataemia syndrome. (18322299)
2008
23
The prevalence of diffuse idiopathic skeletal hyperostosis in an outpatient population in The Netherlands. (18528963)
2008
24
Atypical presentation of osteomyelitis, discitis, epidural, and iliopsoas abscess in diffuse idiopathic skeletal hyperostosis (DISH) syndrome. (18688200)
2008
25
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
26
Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery. (15287538)
2004
27
Parasagittal meningioma en plaque with extracranial extension presenting diffuse massive hyperostosis of the skull. (14751632)
2004
28
Hyperostosis and osteitis in Sapho syndrome: conservative or surgical treatment. (15382585)
2004
29
Spontaneous symptomatic pseudoarthrosis at the T11-T12 intervertebral space with diffuse idiopathic skeletal hyperostosis: a case report. (12923487)
2003
30
Degenerative sternoclavicular arthritis and hyperostosis. (12825539)
2003
31
Sternoclavicular hyperostosis with pathological fracture of the clavicle--a case report. (12767795)
2003
32
A structural chiropractic approach to the management of diffuse idiopathic skeletal hyperostosis. (12704313)
2003
33
Periosteal hyperostosis (exostosis) in DBA/1 male mice. (12051556)
2002
34
Diffuse idiopathic skeletal hyperostosis in a patient with idiopathic retroperitoneal fibrosis: a case report. (12426664)
2002
35
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
36
Hyperextension vertebral body fractures in diffuse idiopathic skeletal hyperostosis: a cause of intravertebral fluidlike collections on MR imaging. (10584819)
1999
37
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
38
Case report. synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. (9161184)
1996
39
Subcutaneous calcifications in diffuse idiopathic skeletal hyperostosis. (7774094)
1995
40
Hyperostosis of ribs: association with vertebral ossification. (8014935)
1993
41
Growth hormone secretion in diffuse idiopathic skeletal hyperostosis. (1524945)
1992
42
Diffuse idiopathic skeletal hyperostosis and situs viscerum inversus. (2585410)
1989
43
Cervical involvement of diffuse idiopathic skeletal hyperostosis with dysphagia and rhinolalia. (3266838)
1988
44
Renal osteodystrophy with facial hyperostosis and 'rubber jaw' in an adult dog. (16031185)
1985
45
Diffuse idiopathic skeletal hyperostosis in a patient with situs inversus. (6860386)
1983
46
An unusual case of diffuse idiopathic skeletal hyperostosis. (6681145)
1983
47
Radiologic aspects of diffuse idiopathic skeletal hyperostosis in the spine. (410264)
1977
48
Infantile cortical hyperostosis of the scapula presenting as an ipsilateral Erb's palsy. (4561478)
1972
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Hypervitaminosis A with infantile cortical hyperostosis. (14850258)
1951

Variations for Hyperostosis

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Expression for genes affiliated with Hyperostosis

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Search GEO for disease gene expression data for Hyperostosis.

Pathways for genes affiliated with Hyperostosis

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Compounds for genes affiliated with Hyperostosis

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Sources:
43Novoseek, 49PharmGKB, 24HMDB, 12DrugBank
See all sources

Compounds related to Hyperostosis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
11,25 dihydroxy vitamin d3439.4FGF23, LRP5
2vitamin d439.4FGF23, LRP5
3phosphorus439.1FGF23, RBP4
4valine438.9RBP4, LRP5
5calcium43 49 24 1211.0LRP5, GALNT3, RBP4, FGF23

GO Terms for genes affiliated with Hyperostosis

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Biological processes related to Hyperostosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oxidation-reduction processGO:00551149.5COX4I2, CYP26C1
2negative regulation of osteoblast differentiationGO:00456689.3FGF23, LRP5
3embryonic retina morphogenesis in camera-type eyeGO:00600599.2RBP4, LRP5
4anterior/posterior pattern specificationGO:00099529.2CYP26C1, LRP5

Products for genes affiliated with Hyperostosis

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Sources for Hyperostosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet