Aliases & Classifications for Hyperostosis

MalaCards integrated aliases for Hyperostosis:

Name: Hyperostosis 12 29 52 42 14 69
Hypertrophy of Bone 12
Bone Hypertrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:205
ICD10 33 M89.3 M89.30
MeSH 42 D015576
NCIt 47 C34712
SNOMED-CT 64 13814009 203514008
UMLS 69 C0020492

Summaries for Hyperostosis

Disease Ontology : 12 A bone remodeling disease that results in an abnormal growth of located in bone.

MalaCards based summary : Hyperostosis, also known as hypertrophy of bone, is related to diffuse idiopathic skeletal hyperostosis and hyperostosis frontalis interna. An important gene associated with Hyperostosis is SOST (Sclerostin). The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and brain.

Wikipedia : 72 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

Related Diseases for Hyperostosis

Diseases related to Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
id Related Disease Score Top Affiliating Genes
1 diffuse idiopathic skeletal hyperostosis 12.4
2 hyperostosis frontalis interna 12.2
3 ankylosing vertebral hyperostosis with tylosis 12.2
4 hyperostosis cranialis interna 12.2
5 hyperostosis, endosteal 12.1
6 calvarial hyperostosis 12.1
7 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.0
8 van buchem disease 12.0
9 caffey disease 11.9
10 dysplastic cortical hyperostosis 11.9
11 polyosteolysis/hyperostosis syndrome 11.8
12 sclerosteosis 11.8
13 sapho syndrome 11.7
14 tumoral calcinosis, hyperphosphatemic, familial 11.7
15 short stature cranial hyperostosis hepatomegaly 11.7
16 short stature, cranial hyperostosis, hepatomegaly and diabetes 11.7
17 isolated sternocostoclavicular hyperostosis 11.7
18 sclerosteosis 1 11.6
19 osteopathia striata with cranial sclerosis 11.5
20 paget disease of bone 5, juvenile-onset 11.5
21 worth's syndrome 11.4
22 camurati-engelmann disease 11.4
23 craniometaphyseal dysplasia 11.1
24 craniodiaphyseal dysplasia 11.0
25 sclerosteosis 2 11.0
26 exostosis 11.0
27 frontometaphyseal dysplasia 2 10.9
28 lenz-majewski hyperostotic dwarfism 10.9
29 weleber hecht bigley syndrome 10.8
30 craniometaphyseal dysplasia, autosomal recessive 10.8
31 craniodiaphyseal dysplasia, autosomal dominant 10.8
32 paget disease of bone 5, juvenile 10.7
33 raine syndrome 10.7
34 melorheostosis, isolated 10.7
35 buschke-ollendorff syndrome 10.7
36 ossification of the posterior longitudinal ligament of spine 10.7
37 acne 10.3
38 synovitis 10.3
39 cervicitis 10.3
40 dysphagia 10.3
41 spondylitis 10.2
42 hyperphosphatemia 10.1
43 osteomyelitis 10.0
44 arthritis 9.9
45 calcinosis 9.9
46 spondylosis 9.9
47 spinal stenosis 9.8
48 psoriatic arthritis 9.8
49 periostitis 9.8
50 hypervitaminosis a 9.8

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to Hyperostosis

Symptoms & Phenotypes for Hyperostosis

Drugs & Therapeutics for Hyperostosis

Drugs for Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 2
5 Antibiotics, Antitubercular Phase 2
6 Antifungal Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Immunosuppressive Agents Phase 2
9
Pamidronate Approved Phase 1 40391-99-9 4674
10 Bone Density Conservation Agents Phase 1
11 Diphosphonates Phase 1
12
Sevelamer Approved 52757-95-6, 152751-57-0 3085017
13
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
14 Analgesics
15 Peripheral Nervous System Agents
16 Chelating Agents
17 Hydroxycholecalciferols
18 Micronutrients
19 Trace Elements
20 Vitamins
21 insulin
22 Insulin, Globin Zinc

Interventional clinical trials:

(show all 21)

id Name Status NCT ID Phase Drugs
1 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
2 Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation Recruiting NCT02428296 Phase 2 Sirolimus
3 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
4 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
5 Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome Completed NCT02544659 Phase 1 pamidronate disodium
6 Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis Completed NCT01417455
7 Nottingham Osteoarthritis Biomarker Study 2011 Completed NCT01495455
8 Immune Response in the SAPHO Syndrome Completed NCT01688219
9 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
10 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
11 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932
12 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
13 Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease Recruiting NCT02504879
14 Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD) Recruiting NCT01630460
15 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100
16 Hypophosphatemic Rickets in Norway Active, not recruiting NCT01057186 Sevelamer
17 Clinical Observation Study With the SBG Stem Active, not recruiting NCT02338661
18 Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal Surgery Enrolling by invitation NCT00984672
19 Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Not yet recruiting NCT03237455
20 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
21 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Hyperostosis

Cochrane evidence based reviews: hyperostosis

Genetic Tests for Hyperostosis

Genetic tests related to Hyperostosis:

id Genetic test Affiliating Genes
1 Hyperostosis 29

Anatomical Context for Hyperostosis

MalaCards organs/tissues related to Hyperostosis:

39
Bone, Spinal Cord, Brain, Lung, Testes, Myeloid, T Cells

Publications for Hyperostosis

Articles related to Hyperostosis:

(show top 50) (show all 769)
id Title Authors Year
1
Odontoid Fracture in a Patient With Diffuse Idiopathic Skeletal Hyperostosis. ( 28255505 )
2017
2
Thoracic spondylolisthesis and spinal cord compression in diffuse idiopathic skeletal hyperostosis: a case report. ( 28363281 )
2017
3
Relationship between diffuse idiopathic skeletal hyperostosis, abdominal aortic calcification and associated metabolic disorders: Data from the Camargo Cohort. ( 28283270 )
2017
4
Diffuse Idiopathic Skeletal Hyperostosis Involving Cervical and Lumbar Spine Presenting with Dysphagia: A Case Report. ( 28819624 )
2017
5
A rare case of Eagle syndrome and diffuse idiopathic skeletal hyperostosis in the cervical spine. ( 28928500 )
2017
6
Delayed leg paraplegia associated with hyperextension injury in patients with diffuse idiopathic skeletal hyperostosis (DISH): case report and review of the literature. ( 28458848 )
2017
7
Cervical diffuse idiopathic skeletal hyperostosis (DISH) causing oropharyngeal dysphagia. ( 28314808 )
2017
8
A case of bronchiolitis obliterans organising pneumonia associated with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. ( 28765183 )
2017
9
Frontal Hyperostosis in the Patients of Craniosynostosis After Cranial Distraction Osteogenesis. ( 28938316 )
2017
10
A rare association of dysphagia and cervical compressive myelopathy in diffuse idiopathic skeletal hyperostosis. ( 28084279 )
2017
11
Diffuse idiopathic skeletal hyperostosis (DISH) - A common but less known cause of back pain. ( 28721001 )
2017
12
Diffuse idiopathic skeletal hyperostosis with cervical myelopathy. ( 28385821 )
2017
13
Imaging findings suggestive of axial spondyloarthritis in diffuse idiopathic skeletal hyperostosis. ( 28371491 )
2017
14
Prevalence of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Spinal Disorders. ( 28243371 )
2017
15
Transorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases. ( 28862553 )
2017
16
Diffuse idiopathic skeletal hyperostosis causing L4 and L5 nerve root entrapment. ( 28941276 )
2017
17
Spinal Epidural Hematoma Related to Vertebral Fracture in an Atypical Rigid Diffuse Idiopathic Skeletal Hyperostosis: A Case Report. ( 28255506 )
2017
18
Diffuse idiopathic skeletal hyperostosis: Can we identify a peripheral pattern? ( 28528871 )
2017
19
Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. ( 28369706 )
2017
20
Prevalence of thoracic diffuse idiopathic skeletal hyperostosis (DISH) in Japanese: Results of chest CT-based cross-sectional study. ( 27697426 )
2017
21
SAPHO Syndrome: Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. ( 28250311 )
2017
22
CT-based morphological analysis of spinal fractures in patients with diffuse idiopathic skeletal hyperostosis. ( 27713008 )
2017
23
Magnetic resonance imaging in diffuse idiopathic skeletal hyperostosis: similarities to axial spondyloarthritis. ( 28364275 )
2017
24
Swallowing disorders among patients with diffuse idiopathic skeletal hyperostosis. ( 28084872 )
2017
25
Hyperostosis Frontalis Interna in Myotonic Dystrophy. ( 28824073 )
2017
26
Diffuse idiopathic skeletal hyperostosis (DISH): an unusual cause of airway obstruction. ( 28298382 )
2017
27
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. ( 28924111 )
2017
28
Hyperostosis Frontalis Interna in a Child With Severe Traumatic Brain Injury. ( 28503629 )
2017
29
Sternocostoclavicular Hyperostosis: An Insufficiently Recognized Clinical Entity. ( 28469489 )
2017
30
Vertebral fracture at the caudal end of a surgical fusion for thoracic vertebral fracture in a patient with diffuse idiopathic skeletal hyperostosis (DISH). ( 28680006 )
2017
31
Treatment-Refractory Sternocostoclavicular Hyperostosis. ( 28751466 )
2017
32
New evidence suggesting a dissociated etiology for cribra orbitalia and porotic hyperostosis. ( 28594081 )
2017
33
Classification criteria for diffuse idiopathic skeletal hyperostosis: a lack of consensus. ( 28371859 )
2017
34
Sternocostoclavicular Hyperostosis: An Ill-Recognized Disease. ( 27527220 )
2016
35
Sacroiliitis and Spondylitis with Sternoclavicular Hyperostosis: SAPHO or an Ankylosing Spondylitis Variant? ( 26712445 )
2016
36
Prolonged Dysphagia due to a Combination of Cerebral Hemorrhage and Diffuse Idiopathic Skeletal Hyperostosis: A Case Report. ( 28664003 )
2016
37
Brain Metastases Mimicking Hyperostosis Frontalis Interna on 99mTc HDP Bone Scintigraphy. ( 27556792 )
2016
38
Somatic AKT1 mutations cause meningiomas colocalizing with a characteristic pattern of cranial hyperostosis. ( 27550858 )
2016
39
Histological characteristics of diffuse idiopathic skeletal hyperostosis. ( 27101345 )
2016
40
Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. ( 27742022 )
2016
41
Dystrophy of the Great Toenail by Subungual Exostosis and Hyperostosis: Three Case Reports with Different Clinical Presentations. ( 27386469 )
2016
42
Phenotypic and Genotypic Characterization and Treatment of a Cohort with Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome. ( 27164190 )
2016
43
Hyperostosis Following Orbital Exenteration. ( 27254545 )
2016
44
The Importance of Recognizing Diffuse Idiopathic Skeletal Hyperostosis for Neurosurgeons: A Review. ( 27021643 )
2016
45
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome - AA challenging diagnosis not to be missed. ( 27263075 )
2016
46
Diffuse Idiopathic Skeletal Hyperostosis (DISH) and non small cell lung cancer: case presentation and review of the literature. ( 27238170 )
2016
47
Whole Body Magnetic Resonance Imaging Features in Diffuse Idiopathic Skeletal Hyperostosis in Conjunction with Clinical Variables to Whole Body MRI and Clinical Variables in Ankylosing Spondylitis. ( 26669910 )
2016
48
Refractory Obstructive Sleep Apnea in a Patient with Diffuse Idiopathic Skeletal Hyperostosis. ( 27957370 )
2016
49
Appearance of Diffuse Idiopathic Skeletal Hyperostosis on Panoramic Images. ( 27317591 )
2016
50
Cord compression and myelopathy due to stress fracture in a patient with diffuse idiopathic skeletal hyperostosis (DISH). ( 26826342 )
2016

Variations for Hyperostosis

Expression for Hyperostosis

Search GEO for disease gene expression data for Hyperostosis.

Pathways for Hyperostosis

GO Terms for Hyperostosis

Sources for Hyperostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....