MCID: HYP069
MIFTS: 63

Hyperparathyroidism malady

Summaries for Hyperparathyroidism

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Hyperparathyroidism is overactivity of the parathyroid glands resulting in excess production of... more...

MalaCards: Hyperparathyroidism is related to primary hyperparathyroidism and adenoma. An important gene associated with Hyperparathyroidism is CDC73 (cell division cycle 73), and among its related pathways are Signaling by GPCR and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs cod liver oil and calcitriol and the compounds calcium and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and thyroid, and related mouse phenotypes are mortality/aging and immune system.

Aliases & Classifications for Hyperparathyroidism

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Aliases & Descriptions:

hyperparathyroidism 8 10 44 60


External Ids:

Disease Ontology8 DOID:13543
ICD9CM27 252.00, 252.0
NCIt39 C48259
MeSH34 D006961

Related Diseases for Hyperparathyroidism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Primary Hyperparathyroidism family:

hyperparathyroidism Hyperparathyroidism 3

Diseases related to Hyperparathyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 313)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperparathyroidism31.9ALPP, BGLAP, CALCA, CASR, GAST, MEN1
2adenoma31.2CALCA, CASR, GAST, MEN1, PRKAR1A, NR1I3
3parathyroid adenoma31.1CALCA, CASR, MEN1, PRKAR1A, VDR, CDC73
4hypercalcemia31.1CDC73, CYP27B1, FGF23, CXADR, SLPI, PTHLH
5parathyroid carcinoma30.9CASR, MEN1, CDC73, RET, PTH
6thyroiditis30.8CALCA
7osteitis fibrosa30.8ALPP, PTH, CASR, BGLAP
8osteomalacia30.7BGLAP, CALCA, CASR, VDR, CYP27B1, FGF23
9hyperparathyroidism-jaw tumor syndrome30.7CDC73
10familial isolated hyperparathyroidism30.7MEN1, CDC73
11renal osteodystrophy30.7BGLAP, CALCA, CASR, VDR, FGF23, SLPI
12uremia30.6PTH, CASR, MEN1, NR1I3, VDR, CXADR
13pancreatitis30.6ALPP, CASR
14goiter30.5BGLAP, CALCA, RET, PTH
15rickets30.5BGLAP, CASR, VDR, CYP27B1, PTH, ALPP
16secondary hyperparathyroidism of renal origin30.4PRKAR1A, NR1I3, VDR, CYP27B1, FGF23, CXADR
17osteoporosis30.4PRKAR1A, NR1I3, VDR, CYP27B1, FGF23, CXADR
18hyperphosphatemia30.4CASR, VDR, FGF23, SLPI, PTH, ALPP
19pheochromocytoma30.4RET, MEN1, CALCA
20peritonitis30.4SLPI
21papillary thyroid carcinoma30.4CALCA, MEN1, RET
22hypoparathyroidism30.4BGLAP, CALCA, CASR, PRKAR1A, NR1I3, ALPP
23hyperthyroidism30.4BGLAP, FGF23, SLPI, ACP5, PTH, ALPP
24osteosclerosis30.4ALPP, PTH
25pseudohypoparathyroidism30.4BGLAP, CALCA, PTHLH, PTH
26thyroid cancer30.3RET, CASR, CALCA
27hyperparathyroidism, neonatal30.3CASR, PRKAR1A, NR1I3, CXADR
28hypertension30.3PTH, CALCA
29giant cell tumor30.2FGF23, CALCA, BGLAP
30obesity30.2NR1I3
31hypophosphatemia30.2BGLAP, CALCA, VDR, CYP27B1, FGF23, PTHLH
32breast cancer30.1NR1I3, PRKAR1A, MEN1, CASR, CALCA, VDR
33calcinosis30.1CASR, FGF23, PTH, ALPP
34fibrous dysplasia30.1BGLAP, FGF23, ALPP
35sarcoidosis30.1ALPP, CYP27B1
36paget's disease of bone30.1BGLAP, CALCA
37ossifying fibroma30.1CDC73
38nephrolithiasis30.0CASR, NR1I3, VDR, FGF23, PTH
39myeloma30.0ALPP, PTHLH, ACP5, BGLAP
40insulinoma30.0MEN1, GAST, CASR, CALCA
41acromegaly30.0PRKAR1A, MEN1, BGLAP
42prolactinoma30.0PTHLH, PRKAR1A, MEN1
43mccune albright syndrome30.0FGF23, PRKAR1A
44duodenitis30.0GAST
45thyroid medullary carcinoma29.9CALCA, CASR, GAST, MEN1, PRKAR1A, RET
46graves' disease29.9BGLAP, CASR, VDR, CYP27B1, FGF23
47arthritis29.9BGLAP, CALCA, VDR, ACP5, ALPP
48melanoma29.9NR1I3, VDR, CYP27B1, CXADR
49x-linked hypophosphatemia29.9VDR, CYP27B1, FGF23
50hypothyroidism29.9PTH, CASR

Graphical network of the top 20 diseases related to Hyperparathyroidism:



Diseases related to hyperparathyroidism

Clinical Features for Hyperparathyroidism

About this section

Drugs & Therapeutics for Hyperparathyroidism

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperparathyroidism

Drug clinical trials:

Search ClinicalTrials for Hyperparathyroidism

Search NIH Clinical Center for Hyperparathyroidism

Search CenterWatch for Hyperparathyroidism

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperparathyroidism

About this section

Anatomical Context for Hyperparathyroidism

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hyperparathyroidism:

32
Bone, Kidney, Thyroid, Testes, Liver, Endothelial, Breast, Lung, Pituitary, Bone marrow, Pancreatic islet, Thymus, Eye, Brain, Skin, Colon, Prostate

Animal Models for Hyperparathyroidism or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Hyperparathyroidism

About this section
Sources:
50PubMed
See all sources

Articles related to Hyperparathyroidism:

(show top 50)    (show all 1704)
idTitleAuthorsYear
1
Cinacalcet monotherapy in neonatal severe hyperparathyroidism: a case study and review. (24203066)
2014
2
Meta-analysis: the efficacy and safety of paricalcitol for the treatment of secondary hyperparathyroidism and proteinuria in chronic kidney disease. (23509710)
2013
3
Medical management of primary hyperparathyroidism. (23374743)
2013
4
Coexistence of paget disease of bone and primary hyperparathyroidism; a diagnostic challenge. (23728113)
2013
5
BMD improvements after operation for primary hyperparathyroidism. (23132462)
2013
6
A comparison of outcomes for younger and older adult patients undergoing surgery for primary hyperparathyroidism. (22207049)
2012
7
Nonsurgical management of mild primary hyperparathyroidism - a reasonable option. (22803518)
2012
8
A comparative study of pre-operative imaging methods in patients with primary hyperparathyroidism: ultrasonography, 99mTc sestamibi, single photon emission computed tomography, and magnetic resonance imaging. (21623148)
2012
9
Calcium intake and risk of primary hyperparathyroidism in women: prospective cohort study. (23080543)
2012
10
Identification of the first germline HRPT2 whole-gene deletion in a patient with primary hyperparathyroidism. (21790700)
2012
11
Increased circulating levels of FGF23: an adaptive response in primary hyperparathyroidism? (21984611)
2012
12
The utility of multidetector computed tomography for detection of parathyroid disease in the setting of primary hyperparathyroidism. (21955750)
2012
13
The impact of secondary hyperparathyroidism on the efficacy of antiresorptive therapy. (23227959)
2012
14
Parathyroid localization with modified 4D-computed tomography and ultrasonography for patients with primary hyperparathyroidism. (21557243)
2011
15
Primary hyperparathyroidism: Update on presentation, diagnosis, and management in primary care. (21321169)
2011
16
Salutary effect of parathyroidectomy on neuropsychiatric symptoms in patients with primary hyperparathyroidism: evaluation using PAS and SF-36v2 scoring systems. (21654129)
2011
17
A rare cause of ulceration with a promising new treatment. Calciphylaxis due to secondary hyperparathyroidism caused by vitamin D deficiency. (20500197)
2010
18
Early-onset, progressive, frequent, extensive, and severe bone mineral and renal complications in multiple endocrine neoplasia type 1-associated primary hyperparathyroidism. (20499354)
2010
19
Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial. (19473635)
2009
20
Recurrence of primary hyperparathyroidism following spontaneous remission with intracapsular hemorrhage of a parathyroid adenoma. (18470672)
2008
21
High prevalence of hypovitaminosis D and secondary hyperparathyroidism in elders living in nonprofit homes in South Brazil. (18401764)
2008
22
Altered acetylcholine metabolism of brain in uremia: role of secondary hyperparathyroidism. (18089458)
2008
23
Effect of cinacalcet cessation in renal transplant recipients with persistent hyperparathyroidism. (17510094)
2007
24
Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene. (17555508)
2007
25
Management of secondary hyperparathyroidism in uremic patients: the role of the new vitamin D analogs. (17347966)
2007
26
Dental findings in a family with hyperparathyroidism-jaw tumor syndrome and a novel HRPT2 gene mutation. (16448924)
2006
27
Tumor-induced hypophosphatemic osteomalacia associated with tertiary hyperparathyroidism: a case report. (16608626)
2006
28
Utilisation of a cryptic non-canonical donor splice site of the gene encoding PARAFIBROMIN is associated with familial isolated primary hyperparathyroidism. (16061557)
2005
29
Vitamin D in normal and pathological parathyroid glands: new prospects for treating hyperparathyroidism (review). (15754035)
2005
30
A rare case of primary hyperparathyroidism with clear cell adenoma. (15118272)
2004
31
Neonatal convulsion revealing maternal hyperparathyroidism: an unusual case of late neonatal hypoparathyroidism. (12942255)
2003
32
Effect of 22-oxacalcitriol on secondary hyperparathyroidism in hemodialysis patients. (14606707)
2003
33
Pathogenesis of refractory secondary hyperparathyroidism. (11982830)
2002
34
Brown tumour of hyperparathyroidism in the mandible associated with atypical parathyroid adenoma. (10845051)
2000
35
Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. (11013439)
2000
36
Increased biochemical markers of bone formation and resorption in primary hyperparathyroidism with special reference to patients with mild disease. (9566639)
1998
37
Remission of primary hyperparathyroidism due to spontaneous infarction of a parathyroid adenoma. Case report and review of the literature. (9854603)
1998
38
No trend toward a spontaneous improvement of hyperparathyroidism and high bone turnover in normocalcemic long-term renal transplant recipients. (9159310)
1997
39
Autosomal dominant primary hyperparathyroidism and jaw tumor syndrome associated with renal hamartomas and cystic kidney disease: linkage to 1q21-q32 and loss of the wild type allele in renal hamartomas. (8954016)
1996
40
Bone remodeling indices and secondary hyperparathyroidism in celiac disease. (8651176)
1996
41
An autopsy case of renal failure as its cause of death in a patient with primary hyperparathyroidism associated with chronic pancreatitis]. (8940801)
1996
42
Chronic calcific pancreatitis associated with osteomalacia and secondary hyperparathyroidism. (8916580)
1996
43
Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure. (8041868)
1994
44
Renal function in hyperparathyroidism with complicating nephrocalcinosis. (8453206)
1993
45
Long-term effects of parathyroidectomy for primary hyperparathyroidism on arterial hypertension. (1413842)
1992
46
Common bone features in osteomalacia, secondary hyperparathyroidism, and renal osteodystrophy. (2054996)
1991
47
Familial hypocalciuric hypercalcemia: description of a new kindred with emphasis on its difference from primary hyperparathyroidism. (2985312)
1985
48
Neonatal primary hyperparathyroidism in familial hypocalciuric hypercalcemia. (7102625)
1982
49
Occurrence of hyperparathyroidism in children with X-linked hypophosphatemia under treatment with vitamin D and phsophate. (899930)
1977
50
PARATHYROID CARCINOMA CAUSING HYPERPARATHYROIDISM. (18731512)
1948

Genetic Variations for Hyperparathyroidism

About this section

Expression for genes affiliated with Hyperparathyroidism

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperparathyroidism

Search GEO for disease gene expression data for Hyperparathyroidism.

Pathways for genes affiliated with Hyperparathyroidism

About this section
Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
See all sources

Pathways related to Hyperparathyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2CALCA, CASR, GAST, MEN1, PRKAR1A, FGF23
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.9BGLAP, CALCA, VDR, CYP27B1, PTH
3
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.9PTH, PTHLH, VDR, PRKAR1A, BGLAP
4
Vitamin D2 (ergocalciferol) metabolism
Hide members
10.7PTH, CYP27B1, VDR
510.7NR1I3, VDR, CYP27B1
610.7PTH, FGF23

Compounds for genes affiliated with Hyperparathyroidism

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Hyperparathyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.4CXADR, ALPP, CALCA, GAST, MEN1, PRKAR1A
2vitamin d4412.3ALPP, PTH, NR1I3, PRKAR1A, MEN1, GAST
3calcitriol44 59 11 2415.1CXADR, SLPI, PTHLH, PTH, ALPP, ACP5
41,25 dihydroxy vitamin d34412.0PTH, PTHLH, ACP5, CXADR, FGF23, CYP27B1
5phosphorus4412.0BGLAP, CALCA, CASR, NR1I3, VDR, CYP27B1
625-hydroxyvitamin d4411.9CYP27B1, VDR, CASR, BGLAP, FGF23, SLPI
7testosterone44 59 11 2414.8CYP27B1, VDR, NR1I3, CALCA, BGLAP, RET
8tyrosine4411.8CASR, PTHLH, ACP5, CXADR, FGF23, RET
9arginine4411.8PTHLH, PTH, ALPP, BGLAP, FGF23, RET
10creatinine4411.8PTH, VDR, PTHLH, ACP5, ALPP, SLPI
11alanine4411.7ALPP, VDR, PTHLH, SLPI, CXADR, RET
12thymidine44 2412.6MEN1, PTHLH, GAST, PTH, SLPI, CXADR
13cyclic amp44 2412.6CASR, NR1I3, CALCA, PRKAR1A, CYP27B1, RET
14serine4411.6RET, CXADR, BGLAP, VDR, ALPP, FGF23
15dexamethasone44 49 28 1114.5VDR, NR1I3, ALPP, BGLAP, CXADR, SLPI
16alendronate44 49 1113.5SLPI, CALCA, VDR, PTHLH, BGLAP, PTH
17hydroxyproline44 11 2413.5BGLAP, CALCA, SLPI, PTH, ALPP, ACP5
18vegf4411.5ALPP, PTH, PTHLH, SLPI, CALCA, BGLAP
19hydroxyapatite4411.5ACP5, FGF23, CASR, ALPP, PTHLH, BGLAP
20neomycin4411.5CXADR, PRKAR1A, NR1I3, GAST, ALPP, PTHLH
21cyclosporin a44 28 5913.5ACP5, NR1I3, CALCA, ALPP, VDR, BGLAP
22alfacalcidol44 59 1113.4SLPI, CYP27B1, VDR, NR1I3, CALCA, BGLAP
23thyroxine44 2412.4CALCA, GAST, VDR, PTHLH, PTH, BGLAP
24cysteine4411.4CXADR, CASR, PRKAR1A, SLPI, VDR, CYP27B1
25pamidronate44 49 1113.4ALPP, BGLAP, CALCA, PTH, CASR, PTHLH
26tartrate4411.4ACP5, SLPI, ALPP, BGLAP, PTHLH, CALCA
27pyridinoline4411.4SLPI, ACP5, CALCA, BGLAP, ALPP, PTHLH
28adenylate4411.4PTHLH, CXADR, PRKAR1A, GAST, CALCA, PTH
29deoxypyridinoline4411.3ACP5, PTH, VDR, CALCA, BGLAP
30clodronate44 49 1113.3ACP5, CALCA, VDR, SLPI, PTHLH
3122-oxacalcitriol4411.3PTHLH, VDR, CASR, BGLAP, ALPP
3224,25-dihydroxyvitamin d34411.3ALPP, CYP27B1, BGLAP, CALCA, VDR
33cinacalcet44 28 1113.3NR1I3, PRKAR1A, CASR, CALCA, CXADR
34calcium carbonate4411.3ALPP, BGLAP, CALCA, PTHLH, PTH
35hydrocortisone44 2 59 1114.3SLPI, ALPP, PTHLH, GAST, BGLAP, CALCA
36eb 108944 5912.3CYP27B1, NR1I3, VDR, PTHLH, BGLAP
37zoledronic acid4411.2BGLAP, CALCA, ALPP, PTHLH, SLPI
38ipriflavone4411.2ALPP, SLPI, BGLAP, CALCA
39etidronate4411.1CALCA, SLPI, ALPP, BGLAP
40heparin44 28 11 2414.1SLPI, BGLAP, FGF23, CXADR, ACP5
41vitamin k24411.1ALPP, SLPI, CALCA, BGLAP
42risedronate44 59 49 28 1115.0BGLAP, CALCA, SLPI, ALPP
43estrogen4411.0VDR
44thiazide4410.9VDR, CASR, CALCA, BGLAP
45calcipotriol44 59 28 1113.9VDR, BGLAP, CYP27B1, NR1I3
46calcifediol5910.9NR1I3, CYP27B1, VDR
47sevelamer4410.7BGLAP, CASR, FGF23
48estradiol44 11 2412.7ACP5, SLPI, NR1I3, PTHLH
49procollagen4410.6ACP5, ALPP
50calcium gluconate4410.4BGLAP, CALCA, GAST

GO Terms for genes affiliated with Hyperparathyroidism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperparathyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0PTH, PTHLH, CXADR, FGF23, CALCA, BGLAP
2extracellular regionGO:00557610.8PTHLH, BGLAP, CALCA, GAST, FGF23, CXADR

Biological processes related to Hyperparathyroidism according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00150111.0BGLAP, VDR, PTHLH, PTH
2positive regulation of vitamin D 24-hydroxylase activityGO:01098011.0FGF23, CYP27B1, VDR
3osteoblast developmentGO:00207611.0PTHLH, MEN1, BGLAP
4negative regulation of cell proliferationGO:00828510.9MEN1, VDR, CDC73, CYP27B1, PTHLH
5positive regulation of cAMP biosynthetic processGO:03081910.9PTH, PTHLH, CALCA
6adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.9CALCA, PTHLH, PTH
7cAMP metabolic processGO:04605810.8PTHLH, PTH
8vitamin D catabolic processGO:04236910.7CYP27B1, FGF23
9response to vitamin DGO:03328010.7CYP27B1, BGLAP
10positive regulation of keratinocyte differentiationGO:04561810.6CYP27B1, VDR
11cellular calcium ion homeostasisGO:00687410.4PTH, VDR, CASR

Molecular functions related to Hyperparathyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.7PTH, PTHLH
2hormone activityGO:00517910.5PTH, PTHLH, GAST, CALCA

Products for genes affiliated with Hyperparathyroidism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperparathyroidism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet