MCID: HYP069
MIFTS: 57

Hyperparathyroidism malady

Summaries for Hyperparathyroidism

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hyperparathyroidism is overactivity of the parathyroid glands resulting in excess production of... more...

MalaCards: Hyperparathyroidism is related to primary hyperparathyroidism and adenoma. An important gene associated with Hyperparathyroidism is CDC73 (cell division cycle 73), and among its related pathways are Signaling by GPCR and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs cod liver oil and calcitriol and the compounds calcium and vitamin d have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and immune system.

Aliases & Classifications for Hyperparathyroidism

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

hyperparathyroidism 8 10 45 61


External Ids:

Disease Ontology8 DOID:13543
ICD9CM27 252.00, 252.0
NCIt40 C48259
MeSH35 D006961

Related Diseases for Hyperparathyroidism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the primary hyperparathyroidism family:

hyperparathyroidism hyperparathyroidism 3

Diseases related to Hyperparathyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 305)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperparathyroidism31.9ALPP, BGLAP, CALCA, CASR, GAST, MEN1
2adenoma31.2CALCA, CASR, GAST, MEN1, PRKAR1A, NR1I3
3hypercalcemia31.2CDC73, CYP27B1, FGF23, CXADR, SLPI, PTHLH
4familial isolated hyperparathyroidism31.0MEN1, CDC73
5hyperparathyroidism, neonatal31.0CASR, PRKAR1A, NR1I3, CXADR
6multiple endocrine neoplasia31.0CALCA, GAST, MEN1, PRKAR1A, CDC73, RET
7parathyroid carcinoma30.9CASR, MEN1, CDC73, RET, PTH
8osteitis fibrosa30.8ALPP, PTH, CASR, BGLAP
9osteomalacia30.8BGLAP, CALCA, CASR, VDR, CYP27B1, FGF23
10hyperparathyroidism-jaw tumor syndrome30.7CDC73
11renal osteodystrophy30.7BGLAP, CALCA, CASR, VDR, FGF23, SLPI
12uremia30.6PTH, CASR, MEN1, NR1I3, VDR, CXADR
13rickets30.5BGLAP, CASR, VDR, CYP27B1, PTH, ALPP
14osteoporosis30.5PRKAR1A, NR1I3, VDR, CYP27B1, FGF23, CXADR
15hyperphosphatemia30.5CASR, VDR, FGF23, SLPI, PTH, ALPP
16pheochromocytoma30.5RET, MEN1, CALCA
17thyroid adenoma30.4RET, PRKAR1A
18hypoparathyroidism30.4BGLAP, CALCA, CASR, PRKAR1A, NR1I3, ALPP
19thyroid cancer30.4RET, CASR, CALCA
20secondary hyperparathyroidism of renal origin30.4PRKAR1A, NR1I3, VDR, CYP27B1, FGF23, CXADR
21hypophosphatemia30.2BGLAP, CALCA, VDR, CYP27B1, FGF23, PTHLH
22osteoporosis, postmenopausal30.1BGLAP, CALCA, VDR, CYP27B1, ACP5, PTHLH
23fibrous dysplasia30.1BGLAP, FGF23, ALPP
24mccune albright syndrome30.1FGF23, PRKAR1A
25ossifying fibroma30.1CDC73
26nephrolithiasis30.0CASR, NR1I3, VDR, FGF23, PTH
27insulinoma30.0MEN1, GAST, CASR, CALCA
28acromegaly30.0PRKAR1A, MEN1, BGLAP
29prolactinoma30.0PTHLH, PRKAR1A, MEN1
30thyroiditis30.0CALCA
31thyroid medullary carcinoma29.9CALCA, CASR, GAST, MEN1, PRKAR1A, RET
32graves' disease29.9BGLAP, CASR, VDR, CYP27B1, FGF23
33arthritis29.9BGLAP, CALCA, VDR, ACP5, ALPP
34carcinoid syndrome29.9RET, MEN1, GAST, CALCA
35hypocalcemia, autosomal dominant29.9CXADR, PRKAR1A, CASR
36hypophosphatasia29.9ALPP, SLPI
37glucagonoma29.9GAST, MEN1
38adenocarcinoma29.7CASR, GAST, MEN1, CYP27B1, CXADR, PTHLH
39gastrinoma29.7CASR, GAST, MEN1
40astrocytoma29.7CASR, NR1I3, CXADR
41atherosclerosis29.7CASR, FGF23
42autosomal dominant disease29.7PTH, RET, CALCA
43adrenal adenoma29.7MEN1, PRKAR1A
44osteogenesis imperfecta29.7ALPP, BGLAP
45cystic fibrosis29.7SLPI
46brachydactyly29.7PTH
47familial hypocalciuric hypercalcemia10.6
48calciphylaxis10.5
49nephrocalcinosis10.3
50n syndrome10.3

Graphical network of the top 20 diseases related to Hyperparathyroidism:



Diseases related to hyperparathyroidism

Clinical Features for Hyperparathyroidism

Drugs & Therapeutics for Hyperparathyroidism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperparathyroidism

Drug clinical trials:

Search ClinicalTrials for Hyperparathyroidism

Search NIH Clinical Center for Hyperparathyroidism

Search CenterWatch for Hyperparathyroidism

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hyperparathyroidism

Anatomical Context for Hyperparathyroidism

Animal Models for Hyperparathyroidism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hyperparathyroidism:

37 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.1NR1I3, PRKAR1A, MEN1, GAST, CASR, CALCA
2MP:000538712.0PTH, CASR, GAST, MEN1, PRKAR1A, VDR
3MP:000537612.0NR1I3, PRKAR1A, MEN1, GAST, CASR, CALCA
4MP:000537811.7VDR, NR1I3, PRKAR1A, MEN1, CASR, CDC73
5MP:000539711.7CASR, PRKAR1A, VDR, CDC73, CYP27B1, RET
6MP:000538111.6CASR, GAST, MEN1, PRKAR1A, VDR, CDC73
7MP:000538411.5CASR, MEN1, PRKAR1A, NR1I3, VDR, CDC73
8MP:000538511.5CALCA, MEN1, PRKAR1A, VDR, CDC73, RET
9MP:000538911.4MEN1, PRKAR1A, NR1I3, VDR, CDC73, CYP27B1
10MP:000537911.4GAST, MEN1, VDR, CDC73, CYP27B1, RET
11MP:000539011.1PRKAR1A, CYP27B1, FGF23, ACP5, PTHLH
12MP:000536711.1CASR, CDC73, CYP27B1, RET, FGF23
13MP:000538011.1MEN1, PRKAR1A, CDC73, RET, CXADR, ALPP
14MP:000536911.0CASR, MEN1, PRKAR1A, VDR, CDC73, RET
15MP:000537110.8FGF23, ACP5
16MP:000538810.7PRKAR1A, CXADR, PTHLH
17MP:001077110.7CALCA, CASR, VDR, CDC73, CYP27B1, FGF23

Publications for Hyperparathyroidism

Sources:
51PubMed
See all sources

Articles related to Hyperparathyroidism:

(show top 50)    (show all 1688)
idTitleAuthorsYear
1
Intraoperative PTH cutoff definition to predict successful parathyroidectomy in secondary and tertiary hyperparathyroidism. (23929152)
2013
2
Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. (23418315)
2013
3
Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism after Renal Transplant. (24234965)
2013
4
Medical management of primary hyperparathyroidism. (23374743)
2013
5
The evaluation of vitamin D status in normocalcemic primary hyperparathyroidism. (23260224)
2013
6
Bilateral adrenal myelolipomas in a woman with chronic anticoagulation, postmenopausal uterine bleeding, primary hyperparathyroidism and hyperthyroidism. (23426084)
2013
7
Massive soft tissue calcifications in severe hyperparathyroidism secondary to end-stage renal disease. (23648814)
2013
8
Muscle Function Is Impaired in Patients With "Asymptomatic" Primary Hyperparathyroidism. (24101026)
2013
9
The effect of parathyroidectomy on chronic constipation in patients affected by primary hyperparathyroidism. (23563978)
2013
10
Clinicopathological analysis of persistent hypercalcemia and hyperparathyroidism after kidney transplantation in long-term dialysis patients. (24107283)
2013
11
Skeletal effects of primary hyperparathyroidism: bone mineral density and fracture risk. (23374738)
2013
12
Cinacalcet effects on the perioperative course of patients with secondary hyperparathyroidism. (23007384)
2013
13
Hyperparathyroidism-jaw tumour syndrome detected by aggressive generalized osteitis fibrosa cystica. (23858315)
2013
14
A novel use of cinacalcet to distinguish primary hyperparathyroidism from hypercalcemia of malignancy in a patient with a low-normal parathyroid hormone concentration. (22336445)
2012
15
Prevalence of cardiovascular risk factors in male and female patients with primary hyperparathyroidism. (21750400)
2012
16
Treatment of secondary hyperparathyroidism with parathyroidectomy instead of cinacalcet: time to pick the low-hanging fruit? (22805518)
2012
17
Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. (22732343)
2012
18
Does contrast-enhanced cervical ultrasonography improve preoperative localization results in patients with sporadic primary hyperparathyroidism? (23230546)
2012
19
Parathyroidectomy improves bone geometry and microarchitecture in female patients with primary hyperparathyroidism: a one-year prospective controlled study using high-resolution peripheral quantitative computed tomography. (22228118)
2012
20
Forearm bone mineral density in familial hypocalciuric hypercalcemia and primary hyperparathyroidism: a comparative study. (21785908)
2011
21
Normal PTH levels in primary hyperparathyroidism: still the same disease? (21537864)
2011
22
Surgeon-performed ultrasound is superior to 99Tc-sestamibi scanning to localize parathyroid adenomas in patients with primary hyperparathyroidism: results in 516 patients over 10 years. (21463783)
2011
23
Hyperparathyroidism-jaw tumor syndrome: a case report. (19942209)
2010
24
Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report. (21143903)
2010
25
Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. (19491068)
2009
26
Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl- oxalate transporter in patients with primary hyperparathyroidism. (19029225)
2009
27
Phosphatemic effect of cinacalcet in kidney transplant recipients with persistent hyperparathyroidism. (18950915)
2008
28
Ischemic stroke as the presenting symptom of primary hyperparathyroidism due to multiple endocrine neoplasia type 1. (18847624)
2008
29
Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism. (18825648)
2008
30
Primary hyperparathyroidism--what the nephrologist should know--an update. (17138574)
2007
31
Obesity is associated with secondary hyperparathyroidism in men with moderate and severe chronic kidney disease. (17702720)
2007
32
Osteomalacia and secondary hyperparathyroidism after kidney transplantation: Relationship to vitamin D deficiency. (17220696)
2007
33
Oral calcium supplementation associated with decreased likelihood of nephrolithiasis prior to surgery for hyperparathyroidism. (18036056)
2007
34
Dental findings in a family with hyperparathyroidism-jaw tumor syndrome and a novel HRPT2 gene mutation. (16448924)
2006
35
Increased plasma concentrations of N-terminal pro-B-type natriuretic peptide in patients with mild primary hyperparathyroidism. (17121527)
2006
36
Coexistence of a parathyroid adenoma and parathyroid cyst causing primary hyperparathyroidism. (14594122)
2003
37
Multiple endocrine neoplasia type 1 polymorphism D418D is associated with sporadic primary hyperparathyroidism. (12324758)
2002
38
Circulating levels of interleukin-6 soluble receptor predict rates of bone loss in patients with primary hyperparathyroidism. (12414855)
2002
39
Primary hyperparathyroidism with duodenal ulcer and H. pylori infection. (12058887)
2002
40
The pathophysiology of primary hyperparathyroidism. (12412774)
2002
41
Usefulness of [99mTC]MIBI and [18F]fluorodeoxyglucose for imaging recurrent medullary thyroid cancer and hyperparathyroidism in MEN 2a syndrome. (11881324)
2001
42
Sigmoid colon cancer associated with primary hyperparathyroidism: report of a case. (10483759)
1999
43
The effect of surgical treatment on secondary hyperaldosteronism and relative hyperinsulinemia in primary hyperparathyroidism. (9625366)
1998
44
Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism. (9329389)
1997
45
Primary hyperparathyroidism complicated by osteomalacia. (8937594)
1996
46
Circulating concentrations of parathyroid hormone-like peptide in malignancy and in hyperparathyroidism. (2316398)
1990
47
Thallium-201 and technetium-99m subtraction scanning of the parathyroid glands in patients with hyperparathyroidism due to renal osteodystrophy. (3038464)
1987
48
Effects of secretin on parathyroid hormone and calcium in normal subjects, patients with hyperparathyroidism and patients with gastrinoma. (3993434)
1985
49
Kidney function and structure in experimental hyperparathyroidism and hypervitaminosis D. (13890267)
1962
50
WEEKLY clinicopathological exercises; parathyroid carcinoma with hyperparathyroidism and with metastases to liver. (13025711)
1953

Genetic Variations for Hyperparathyroidism

Expression for genes affiliated with Hyperparathyroidism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperparathyroidism

Search GEO for disease gene expression data for Hyperparathyroidism.

Pathways for genes affiliated with Hyperparathyroidism

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Hyperparathyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2CALCA, CASR, GAST, MEN1, PRKAR1A, FGF23
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.9BGLAP, CALCA, VDR, CYP27B1, PTH
3
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.9PTH, PTHLH, VDR, PRKAR1A, BGLAP
4
Vitamin D2 (ergocalciferol) metabolism
Hide members
10.7PTH, CYP27B1, VDR
510.7NR1I3, VDR, CYP27B1
610.7PTH, FGF23

Compounds for genes affiliated with Hyperparathyroidism

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Hyperparathyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2415.4CXADR, ALPP, CALCA, GAST, MEN1, PRKAR1A
2vitamin d4512.3ALPP, PTH, NR1I3, PRKAR1A, MEN1, GAST
3calcitriol45 60 11 2415.1CXADR, SLPI, PTHLH, PTH, ALPP, ACP5
41,25 dihydroxy vitamin d34512.0PTH, PTHLH, ACP5, CXADR, FGF23, CYP27B1
5phosphorus4512.0BGLAP, CALCA, CASR, NR1I3, VDR, CYP27B1
625-hydroxyvitamin d4511.9CYP27B1, VDR, CASR, BGLAP, FGF23, SLPI
7testosterone45 60 11 2414.8CYP27B1, VDR, NR1I3, CALCA, BGLAP, RET
8tyrosine4511.8CASR, PTHLH, ACP5, CXADR, FGF23, RET
9arginine4511.8PTHLH, PTH, ALPP, BGLAP, FGF23, RET
10creatinine4511.8PTH, VDR, PTHLH, ACP5, ALPP, SLPI
11alanine4511.7ALPP, VDR, PTHLH, SLPI, CXADR, RET
12thymidine45 2412.6MEN1, PTHLH, GAST, PTH, SLPI, CXADR
13cyclic amp45 2412.6CASR, NR1I3, CALCA, PRKAR1A, CYP27B1, RET
14serine4511.6RET, CXADR, BGLAP, VDR, ALPP, FGF23
15dexamethasone45 50 29 1114.5VDR, NR1I3, ALPP, BGLAP, CXADR, SLPI
16alendronate45 50 1113.5SLPI, CALCA, VDR, PTHLH, BGLAP, PTH
17hydroxyproline45 11 2413.5BGLAP, CALCA, SLPI, PTH, ALPP, ACP5
18vegf4511.5ALPP, PTH, PTHLH, SLPI, CALCA, BGLAP
19hydroxyapatite4511.5ACP5, FGF23, CASR, ALPP, PTHLH, BGLAP
20neomycin4511.5CXADR, PRKAR1A, NR1I3, GAST, ALPP, PTHLH
21cyclosporin a45 29 6013.5ACP5, NR1I3, CALCA, ALPP, VDR, BGLAP
22alfacalcidol45 60 1113.4SLPI, CYP27B1, VDR, NR1I3, CALCA, BGLAP
23thyroxine45 2412.4CALCA, GAST, VDR, PTHLH, PTH, BGLAP
24cysteine4511.4CXADR, CASR, PRKAR1A, SLPI, VDR, CYP27B1
25pamidronate45 50 1113.4ALPP, BGLAP, CALCA, PTH, CASR, PTHLH
26tartrate4511.4ACP5, SLPI, ALPP, BGLAP, PTHLH, CALCA
27pyridinoline4511.4SLPI, ACP5, CALCA, BGLAP, ALPP, PTHLH
28adenylate4511.4PTHLH, CXADR, PRKAR1A, GAST, CALCA, PTH
29deoxypyridinoline4511.3ACP5, PTH, VDR, CALCA, BGLAP
30clodronate45 50 1113.3ACP5, CALCA, VDR, SLPI, PTHLH
3122-oxacalcitriol4511.3PTHLH, VDR, CASR, BGLAP, ALPP
3224,25-dihydroxyvitamin d34511.3ALPP, CYP27B1, BGLAP, CALCA, VDR
33cinacalcet45 29 1113.3NR1I3, PRKAR1A, CASR, CALCA, CXADR
34calcium carbonate4511.3ALPP, BGLAP, CALCA, PTHLH, PTH
35hydrocortisone45 2 60 1114.3SLPI, ALPP, PTHLH, GAST, BGLAP, CALCA
36eb 108945 6012.3CYP27B1, NR1I3, VDR, PTHLH, BGLAP
37zoledronic acid4511.2BGLAP, CALCA, ALPP, PTHLH, SLPI
38ipriflavone4511.2ALPP, SLPI, BGLAP, CALCA
39etidronate4511.1CALCA, SLPI, ALPP, BGLAP
40heparin45 29 11 2414.1SLPI, BGLAP, FGF23, CXADR, ACP5
41vitamin k24511.1ALPP, SLPI, CALCA, BGLAP
42risedronate45 60 50 29 1115.0BGLAP, CALCA, SLPI, ALPP
43estrogen4511.0VDR
44thiazide4510.9VDR, CASR, CALCA, BGLAP
45calcipotriol45 60 29 1113.9VDR, BGLAP, CYP27B1, NR1I3
46calcifediol6010.9NR1I3, CYP27B1, VDR
47sevelamer4510.7BGLAP, CASR, FGF23
48estradiol45 11 2412.7ACP5, SLPI, NR1I3, PTHLH
49procollagen4510.6ACP5, ALPP
50calcium gluconate4510.4BGLAP, CALCA, GAST

GO Terms for genes affiliated with Hyperparathyroidism

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperparathyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0PTH, PTHLH, CXADR, FGF23, CALCA, BGLAP
2extracellular regionGO:00557610.8PTHLH, BGLAP, CALCA, GAST, FGF23, CXADR

Biological processes related to Hyperparathyroidism according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00150111.0BGLAP, VDR, PTHLH, PTH
2positive regulation of vitamin D 24-hydroxylase activityGO:01098011.0FGF23, CYP27B1, VDR
3osteoblast developmentGO:00207611.0PTHLH, MEN1, BGLAP
4negative regulation of cell proliferationGO:00828510.9MEN1, VDR, CDC73, CYP27B1, PTHLH
5positive regulation of cAMP biosynthetic processGO:03081910.9PTH, PTHLH, CALCA
6adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.9CALCA, PTHLH, PTH
7cAMP metabolic processGO:04605810.8PTHLH, PTH
8vitamin D catabolic processGO:04236910.7CYP27B1, FGF23
9response to vitamin DGO:03328010.7CYP27B1, BGLAP
10positive regulation of keratinocyte differentiationGO:04561810.6CYP27B1, VDR
11cellular calcium ion homeostasisGO:00687410.4PTH, VDR, CASR

Molecular functions related to Hyperparathyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.7PTH, PTHLH
2hormone activityGO:00517910.5PTH, PTHLH, GAST, CALCA

Products for genes affiliated with Hyperparathyroidism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperparathyroidism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet