MCID: HYP025
MIFTS: 42

Hyperphosphatemia malady

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Summaries for Hyperphosphatemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of... more...

MalaCards: Hyperphosphatemia is related to hyperostosis and hyperparathyroidism. An important gene associated with Hyperphosphatemia is FGF23 (fibroblast growth factor 23), and among its related pathways are FGF signaling pathway and Osteoblast Signaling. The compounds foscarnet and procollagen have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and smooth muscle, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Aliases & Classifications for Hyperphosphatemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH
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Aliases & Descriptions:

hyperphosphatemia 8 10 45 62


External Ids:

Disease Ontology8 DOID:0050459
MeSH35 D054559

Related Diseases for Hyperphosphatemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperphosphatemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1hyperostosis30.8FGF23, GALNT3
2hyperparathyroidism30.7FGF23, PTH
3calcinosis30.6FGF23, GALNT3, PTH, SPP1
4hypercalcemia30.5MGP, PTH, FGF23
5hyperphosphatemic familial tumoral calcinosis30.5GALNT3, FGF23
6uremia30.4SPP1, PTH
7hypophosphatemia30.3SLC34A1, PTH, FGF23
8kidney disease10.6
9hyperostosis-hyperphosphatemia syndrome10.5
10leukemia10.5
11peritonitis10.4
12lymphoblastic leukemia10.3
13lactic acidosis10.3
14familial tumoral calcinosis10.3
15multiple myeloma10.2
16myeloma10.2
17blindness10.2
18hypervitaminosis d10.1FGF23
19burns10.1
20metabolic acidosis10.1
21x-linked hypophosphatemia10.0FGF23, SLC34A1
22rickets10.0PTH, FGF23
23renal osteodystrophy10.0PTH, FGF23
24hypoparathyroidism10.0PTH, FGF23
25nephrocalcinosis10.0SPP1, SLC34A1
26primary hyperparathyroidism10.0PTH, FGF23
27secondary hyperparathyroidism of renal origin10.0FGF23, PTH
28osteomalacia10.0PTH, FGF23
29hyperthyroidism10.0FGF23, PTH
30secondary syphilis10.0SPP1, PTH, FGF23
31arteriosclerosis10.0SPP1, MGP
32chronic kidney failure10.0PTH, FGF23, SPP1
33primary hyperoxaluria9.9MGP, FGF23, PTH
34neuronitis9.9
35intussusception9.9
36acute leukemia9.9
37angioid streaks9.9
38cushing's syndrome9.9
39gastroschisis9.9
40bulimia nervosa9.9
41calciphylaxis9.9
42hypophosphatasia9.9
43chronic lymphocytic leukemia9.9
44colorectal cancer9.9
45hypertension9.9
46nephrotic syndrome9.9
47proteinuria9.9
48t-cell leukemia9.9
49hypoparathyroidism familial isolated9.9
50pseudohypoparathyroidism type 1b9.9

Graphical network of the top 20 diseases related to Hyperphosphatemia:



Diseases related to hyperphosphatemia

Symptoms for Hyperphosphatemia

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Drugs & Therapeutics for Hyperphosphatemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hyperphosphatemia

Search NIH Clinical Center for Hyperphosphatemia

Genetic Tests for Hyperphosphatemia

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Anatomical Context for Hyperphosphatemia

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33MalaCards
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MalaCards organs/tissues related to Hyperphosphatemia:

33
Kidney, Bone, Smooth muscle, Colon, Liver, Skin, Retina, T cells, Heart, Testes, Lung, Pituitary

Animal Models for Hyperphosphatemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hyperphosphatemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0GALNT3, PTH, FGF23
2MP:00053898.5FGF23, SLC34A1, GALNT3, SPP1
3MP:00053677.9FGF23, SPP1, SLC34A1, GALNT3, MGP
4MP:00053857.6PTH, FGF23, GALNT3, SPP1, MGP
5MP:00053907.3MGP, SPP1, FGF23, SLC34A1, GALNT3, PTH
6MP:00107687.3FGF23, PTH, SPP1, MGP, SLC34A1
7MP:00053787.2SPP1, MGP, PTH, GALNT3, SLC34A1, FGF23
8MP:00053767.2GALNT3, SPP1, MGP, PTH, SLC34A1, FGF23

Publications for Hyperphosphatemia

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52PubMed
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Articles related to Hyperphosphatemia:

(show top 50)    (show all 356)
idTitleAuthorsYear
1
Effects and safety of lanthanum carbonate in end stage renal disease patients with hyperphosphatemia: a meta-analysis--system review of lanthanum carbonate. (23992043)
2013
2
Long-term treatment of hyperphosphatemia with bixalomer in Japanese hemodialysis patients. (24330556)
2013
3
Dose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. (23369827)
2013
4
Chewability testing in the development of a chewable tablet for hyperphosphatemia. (24010939)
2013
5
Novel cyclodextrin nanosponges for delivery of calcium in hyperphosphatemia. (23954237)
2013
6
The management of hyperphosphatemia by lanthanum carbonate in chronic kidney disease patients. (22723728)
2012
7
A 90-year-old man with hyperphosphatemia. (20951488)
2011
8
Safety and efficacy of nicotinamide in the management of hyperphosphatemia in patients on hemodialysis. (22022084)
2011
9
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells. (21719763)
2011
10
Reduction of hyperphosphatemia is related with the reduction of C-reactive protein in dialysis patients. Study in sevelamer-resistant dialysis patients treated with chitosan chewing gum as salivary phosphate binder. (21219199)
2011
11
Lower body weight and female gender: hyperphosphatemia risk factors after sodium phosphate preparations. (21677840)
2011
12
Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)
2009
13
Salivary phosphorus binding: a novel approach to control hyperphosphatemia. (19244574)
2009
14
Efficacy of hyperphosphatemia control in the progression of chronic renal failure and the prevalence of cardiovascular calcification. (19203546)
2009
15
Treatment of hyperphosphatemia with sevelamer hydrochloride in dialysis patients: effects on vascular calcification, bone and a close look into the survival data. (19034324)
2008
16
Hyperphosphatemia and its treatment. 1983. (19010018)
2008
17
Extreme hyperphosphatemia and hypocalcemic coma associated with phosphate enema. (18379152)
2008
18
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. (16985213)
2007
19
Phosphate salivary secretion in hemodialysis patients: implications for the treatment of hyperphosphatemia. (17220638)
2007
20
Management of hyperphosphatemia. (17014508)
2006
21
Hyperphosphatemia and phosphate binders. (16278327)
2005
22
Tumoral calcinosis with hyperphosphatemia. (16272668)
2005
23
Treatment of hyperphosphatemia in patients with chronic kidney disease on maintenance hemodialysis. (15882308)
2005
24
The role of daily dialysis in the control of hyperphosphatemia. (15882310)
2005
25
Hyperphosphatemia in children receiving peritoneal dialysis--an educational program. (15875218)
2005
26
Severe hyperphosphatemia and hypocalcemia following the rectal administration of a phosphate-containing Fleet pediatric enema. (15232246)
2004
27
Consequences of hyperphosphatemia in patients with end-stage renal disease (ESRD). (15296501)
2004
28
Dietary habits and counseling focused on phosphate intake in hemodialysis patients with hyperphosphatemia. (15483782)
2004
29
FGF-23 is elevated by chronic hyperphosphatemia. (15356053)
2004
30
Hyperphosphatemia in multiple myeloma. (14667570)
2003
31
Calcium acetate versus calcium carbonate in the control of hyperphosphatemia in hemodialysis patients. (11120549)
2000
32
A randomized trial of sevelamer hydrochloride (RenaGel) with and without supplemental calcium. Strategies for the control of hyperphosphatemia and hyperparathyroidism in hemodialysis patients. (9988142)
1999
33
Hyperphosphatemia associated with phosphorus-containing laxatives in a patient with chronic renal insufficiency. (9042182)
1997
34
Hypocalcemia and hyperphosphatemia after phosphate enema use in a child. (9269980)
1997
35
Review of the literature: severe hyperphosphatemia. (7573122)
1995
36
Hyperphosphatemia: an objective marker for bulimia nervosa? (7648849)
1995
37
Hyperphosphatemia in multiple myeloma due to a phosphate-binding immunoglobulin. (1913479)
1991
38
Hyperphosphatemia in infantile hypophosphatasia: implications for carrier diagnosis and screening. (2301398)
1990
39
Extensive extraosseous localization of bone imaging agent in a patient with renal failure and rhabdomyolysis accompanied by combined hypercalcemia and hyperphosphatemia. (2544339)
1989
40
Management of hyperphosphatemia with calcium citrate in hemodialysis patients. (2710274)
1989
41
The role of metabolic acidosis in causing uremic hyperphosphatemia. (3007964)
1986
42
Elevated serum calcitriol concentrations do not fall in response to hyperphosphatemia in familial tumoral calcinosis. (3839626)
1985
43
Intense pyrophosphate heart and lung uptake in a patient with marked hyperphosphatemia. (6321078)
1984
44
Acute renal failure caused by extreme hyperphosphatemia after chemotherapy of an acute lymphoblastic leukemia. (6585264)
1984
45
Enema-induced hypocalcemia and hyperphosphatemia leading to cardiac arrest during induction of anesthesia in an outpatient surgery center. (6650917)
1983
46
Hyperphosphatemia and hypocalcemia in lemurs. (104937)
1978
47
The "anemia" of childhood: evidence for a physiologic response to hyperphosphatemia. (4684041)
1973
48
Sudden death after phosphorus burns: experimental observations of hypocalcemia, hyperphosphatemia and electrocardiographic abnormalities following production of a standard white phosphorus burn. (5113459)
1971
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Oral aluminium hydroxide in the treatment of hyperphosphatemia and acidosis in acute and chronic renal insufficiency. (14465480)
1962

Variations for Hyperphosphatemia

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Expression for genes affiliated with Hyperphosphatemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperphosphatemia

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Pathways for genes affiliated with Hyperphosphatemia

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Hyperphosphatemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5FGF23, SPP1
29.4FGF23, PTH
39.3SPP1, PTH
49.3PTH, SPP1
58.5PTH, MGP, SPP1

Compounds for genes affiliated with Hyperphosphatemia

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 24HMDB, 51PharmGKB
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Compounds related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1foscarnet45 1110.5SLC34A1, SPP1
2procollagen459.2PTH, SPP1
3gamma-carboxyglutamic acid459.2MGP, SPP1
425-hydroxyvitamin d459.1SPP1, PTH, FGF23
5creatinine458.9SPP1, PTH, FGF23
6hydroxyapatite458.9SPP1, MGP, FGF23
7phosphorus458.7SPP1, PTH, SLC34A1, FGF23
8arginine458.6FGF23, PTH, SPP1
91,25 dihydroxy vitamin d3458.6FGF23, SLC34A1, PTH, SPP1
10estrogen458.5PTH, MGP, SPP1
11calcitriol45 61 24 1110.8FGF23, SLC34A1, PTH, MGP, SPP1
12vitamin d457.8SPP1, MGP, PTH, SLC34A1, FGF23
13calcium45 51 24 1110.3SPP1, MGP, PTH, GALNT3, SLC34A1, FGF23

GO Terms for genes affiliated with Hyperphosphatemia

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16Gene Ontology
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Cellular components related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9FGF23, PTH, SPP1
2perinuclear region of cytoplasmGO:0484718.7SLC34A1, GALNT3, SPP1

Biological processes related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:0550629.6FGF23, SLC34A1
2response to lead ionGO:0102889.3SLC34A1, PTH
3response to vitamin DGO:0332809.2SPP1, PTH
4ossificationGO:0015039.1SLC34A1, MGP
5response to cadmium ionGO:0466869.0SLC34A1, PTH

Products for genes affiliated with Hyperphosphatemia

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Sources for Hyperphosphatemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet