MCID: HYP025
MIFTS: 50

Hyperphosphatemia malady

Summaries for Hyperphosphatemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of... more...

MalaCards: Hyperphosphatemia is related to hyperostosis and calcinosis. An important gene associated with Hyperphosphatemia is FGF23 (fibroblast growth factor 23), and among its related pathways are Osteoclast Signaling and Vitamin D2 (ergocalciferol) metabolism. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and smooth muscle, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Hyperphosphatemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

hyperphosphatemia 8 10 44 60


External Ids:

Disease Ontology8 DOID:0050459
MeSH34 D054559

Related Diseases for Hyperphosphatemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperphosphatemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1hyperostosis30.6FGF23, GALNT3
2calcinosis30.6CASR, GALNT3, EMP1, FGF23, PTH, SPP1
3leukemia30.6RUNX2, BMP2, VDR, SLPI, SLC20A1, ALPP
4hyperparathyroidism30.6CASR, TNFRSF11B, EMP1, VDR, FGF23, SLPI
5peritonitis30.5SLPI
6hypercalcemia30.5PTH, ALPP, ALPPL2, SLPI, FGF23, CASR
7hyperphosphatemic familial tumoral calcinosis30.4GALNT3, FGF23
8uremia30.3CASR, TNFRSF11B, VDR, PTH, SPP1
9multiple myeloma30.3TNFRSF11B
10myeloma30.2TNFRSF11B, BMP2, SPP1, ALPP, ALPPL2
11hypophosphatemia30.2SFRP4, EMP1, VDR, FGF23, SLC34A1, PTH
12metabolic acidosis30.0PTH
13vascular disease30.0ALPPL2, ALPP, MGP
14hypertension29.8PTH
15hypoparathyroidism familial isolated29.8GCM2, CASR, PTH
16hypophosphatasia29.8ALPPL2, ALPP, SLPI
17pseudohypoparathyroidism type 1b29.8GNAS, STX16, PTH
18hypoparathyroidism29.8PTH, ALPP, FGF23, CASR, GCM2
19colorectal cancer29.8ALPPL2, ALPP, VDR, CASR
20kidney disease10.6
21hyperostosis-hyperphosphatemia syndrome10.4
22acute leukemia10.3
23lymphoblastic leukemia10.3
24lactic acidosis10.2
25burns10.0
26coronary stenosis10.0
27hypervitaminosis d10.0FGF23
28short stature10.0GNAS
29prostatitis10.0VDR
30obesity10.0GNAS
31keutel syndrome10.0MGP
32insulin resistance10.0GNAS
33ankylosis10.0BMP2
34sarcoidosis10.0ALPP
35hepatitis10.0ALPP
36mccune albright syndrome10.0GNAS, FGF23
37arteriosclerosis10.0SPP1, MGP
38hypophosphatemic rickets, autosomal dominant10.0FGF23, SFRP4
39leydig cell tumor10.0GNAS
40paget's disease of bone10.0ALPP, ALPPL2
41pituitary tumors10.0BMP2, GNAS
42pancreatic cancer10.0VDR, BMP2
43gingivitis10.0ALPP, TNFRSF11B
44root resorption10.0TNFRSF11B, BMP2
45goiter10.0PTH, GNAS
46hypercalciuria, absorptive10.0VDR, CASR
47diarrhea10.0ALPP, ALPPL2
48cystic fibrosis10.0SLPI, TNFRSF11B
49parathyroid carcinoma10.0PTH, CASR
50arthropathy10.0FGF23, BMP2, TNFRSF11B

Graphical network of the top 20 diseases related to Hyperphosphatemia:



Diseases related to hyperphosphatemia

Clinical Features for Hyperphosphatemia

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Drugs & Therapeutics for Hyperphosphatemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperphosphatemia

Drug clinical trials:

Search ClinicalTrials for Hyperphosphatemia

Search NIH Clinical Center for Hyperphosphatemia

Search CenterWatch for Hyperphosphatemia

Genetic Tests for Hyperphosphatemia

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Anatomical Context for Hyperphosphatemia

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32MalaCards
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MalaCards organs/tissues related to Hyperphosphatemia:

32
Kidney, Bone, Smooth muscle, Colon, Liver, Retina, Pituitary, T cells, Heart, Lung, Skin, Testes

Animal Models for Hyperphosphatemia or affiliated genes

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36MGI
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Publications for Hyperphosphatemia

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50PubMed
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Articles related to Hyperphosphatemia:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
Efficacy and tolerability of lanthanum carbonate in treatment of hyperphosphatemia patients receiving dialysis - a systematic review and meta-analysis of randomized controlled trials. (24063635)
2014
2
Dose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. (23369827)
2013
3
Massive hyperphosphatemia in a patient with neuronal intestinal dysplasia after bowel preparation with oral sodium phosphate. (23713794)
2013
4
Lanthanum carbonate versus placebo for management of hyperphosphatemia in patients undergoing peritoneal dialysis: a subgroup analysis of a phase 2 randomized controlled study of dialysis patients. (23418668)
2013
5
Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. (22513315)
2013
6
Effects of phosphonoformic acid and renagel on renal type IIa sodium-dependent phosphate cotransporter mRNA expression in hyperphosphatemia rats. (22260362)
2012
7
Npt2b deletion attenuates hyperphosphatemia associated with CKD. (22859851)
2012
8
Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients. (21135547)
2011
9
Cost-effectiveness of lanthanum carbonate versus sevelamer hydrochloride for the treatment of hyperphosphatemia in patients with end-stage renal disease: a US payer perspective. (22152168)
2011
10
Hyperphosphatemia in a 56-year-old man with hypochondrial pain. (20511470)
2010
11
Flow-through peritoneal dialysis in neonatal enema-induced hyperphosphatemia. (20526851)
2010
12
Hyperphosphatemia after sodium phosphate laxatives in low risk patients: prospective study. (20014460)
2009
13
Salivary phosphate-binding chewing gum reduces hyperphosphatemia in dialysis patients. (19020004)
2009
14
Treatment of hyperphosphatemia with sevelamer hydrochloride in dialysis patients: effects on vascular calcification, bone and a close look into the survival data. (19034324)
2008
15
Hyperphosphatemia of chronic kidney disease. (18449174)
2008
16
Sevelamer carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on hemodialysis. (19209264)
2008
17
Correlation among hyperphosphatemia, type II sodium phosphate transporter activity, and vitamin D metabolism in Fgf-23 null mice. (17646263)
2007
18
Emerging drugs for hyperphosphatemia. (17874966)
2007
19
Treatment of hyperphosphatemia in patients with chronic kidney disease on maintenance hemodialysis. (15882308)
2005
20
Mild hyperphosphatemia and mortality in hemodialysis patients. (15983959)
2005
21
FGF-23 is elevated by chronic hyperphosphatemia. (15356053)
2004
22
Adverse effects of hyperphosphatemia on myocardial hypertrophy, renal function, and bone in rats with renal failure. (15569312)
2004
23
Efficacy and safety of sevelamer. Comparison with calcium carbonate in the treatment of hyperphosphatemia in hemodialysis patients. (15195212)
2004
24
Calcium salts in the treatment of hyperphosphatemia in hemodialysis patients. (12815333)
2003
25
How should hyperphosphatemia be managed in dialysis patients? (12358631)
2002
26
Cost-effectiveness of sevelamer versus calcium carbonate plus atorvastatin to reduce LDL in patients with chronic renal insufficiency with dyslipidemia and hyperphosphatemia. (10939556)
2000
27
Extreme hyperphosphatemia and acute renal failure after a phosphorus-containing bowel regimen. (10085452)
1999
28
Hyperphosphatemia in end-stage renal disease patients: pathophysiological consequences. (10633461)
1999
29
Poly[allylamine hydrochloride] (RenaGel): a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure. (9002531)
1997
30
The treatment of uremic hyperphosphatemia. (8905221)
1996
31
Review of the literature: severe hyperphosphatemia. (7573122)
1995
32
Management of hyperphosphatemia in patients with renal failure. (7859019)
1993
33
Chronic respiratory alkalosis induces renal PTH-resistance, hyperphosphatemia and hypocalcemia in humans. (1405350)
1992
34
Effects of hyperphosphatemia on diaphragmatic strength and endurance. (1506403)
1992
35
Control of predialytic hyperphosphatemia by oral calcium acetate and calcium carbonate. Comparable efficacy for half the dose of elemental calcium given as acetate without lower incidence of hypercalcemia. (1738415)
1992
36
Clinical factors in progressive renal injury. The role of hyperphosphatemia. (2024674)
1991
37
Management of hyperphosphatemia with calcium citrate in hemodialysis patients. (2710274)
1989
38
Colonic intussusception secondary to a calcium phosphate bezoar in a child receiving calcium carbonate for hyperphosphatemia. (2809998)
1989
39
Hyperphosphatemia associated with cortical hyperostosis and tumoral calcinosis. (2656956)
1989
40
More on the role of metabolic acidosis in causing uremic hyperphosphatemia. (3587185)
1987
41
Prevention of phosphate retention and hyperphosphatemia in uremia. (3323615)
1987
42
Hyperphosphatemia after surgical correction of hypercortisolism in patients with Cushing's syndrome. (3960015)
1986
43
Hyperphosphatemia as a detectable laboratory manifestation of glucocorticoid withdrawal syndrome. (3508717)
1986
44
Spurious hyperphosphatemia due to hyperlipidemia. (3985738)
1985
45
Enema-induced hypocalcemia and hyperphosphatemia leading to cardiac arrest during induction of anesthesia in an outpatient surgery center. (6650917)
1983
46
Letter: Acute hyperphosphatemia and acute persistent renal insufficiency induced by oral phosphate therapy. (1166985)
1975
47
Possible pathogenetic factors in neonatal hypocalcemia of prematurity. The role of gestation, hyperphosphatemia, hypomagnesemia, urinary calcium loss, and parathormone responsiveness. (4698930)
1973
48
Sudden death after phosphorus burns: experimental observations of hypocalcemia, hyperphosphatemia and electrocardiographic abnormalities following production of a standard white phosphorus burn. (5113459)
1971
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Studies of neonatal hyperphosphatemia. (13880886)
1962

Genetic Variations for Hyperphosphatemia

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Expression for genes affiliated with Hyperphosphatemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperphosphatemia

Search GEO for disease gene expression data for Hyperphosphatemia.

Pathways for genes affiliated with Hyperphosphatemia

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Hyperphosphatemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SPP1, TNFRSF11B
2
Vitamin D2 (ergocalciferol) metabolism
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10.2PTH, VDR
3
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10.2SLC34A1, SLC20A1
410.1PTH, FGF23, TNFRSF11B
510.1SPP1, FGF23, RUNX2
610.0ALPPL2, ALPP
79.9RUNX2, MGP, PTH, SPP1
8
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.7RUNX2, TNFRSF11B, VDR, PTH, SPP1
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.7SPP1, PTH, VDR, GNAS, RUNX2

Compounds for genes affiliated with Hyperphosphatemia

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1procollagen4410.7ALPP
2estrogen4410.6VDR, MGP
3deoxypyridinoline4410.4PTH, VDR, TNFRSF11B
4butyrate4410.4ALPPL2, RUNX2
5fibroin4410.4SPP1, BMP2, RUNX2
6cycloheximide4410.4ALPP, PTH, RUNX2
7polycaprolactone4410.3RUNX2, BMP2, ALPP
8foscarnet44 1111.3RUNX2, SLC34A1, SLC20A1, SPP1
922-oxacalcitriol4410.3ALPP, VDR, CASR
10pamidronate44 49 1112.2CASR, TNFRSF11B, PTH, ALPP
11etidronate4410.2TNFRSF11B, SLPI, ALPP
12zoledronic acid4410.1TNFRSF11B, BMP2, SLPI, ALPP
13raloxifene44 28 49 1113.1TNFRSF11B, BMP2, VDR, SLPI
14levamisole44 1111.1SLPI, SPP1, ALPP, ALPPL2
15vitamin k24410.1TNFRSF11B, SLPI, ALPP
16alizarin4410.1RUNX2, BMP2, SLPI, SPP1, ALPP
17hydroxyproline44 11 2412.1TNFRSF11B, SLPI, PTH, ALPP
18glucose4410.0RUNX2, CASR, SLPI, PTH
19tgf beta14410.0SPP1, SLPI, BMP2, TNFRSF11B, RUNX2
20chitosan4410.0ALPP, SPP1, BMP2
21risedronate44 59 49 28 1114.0TNFRSF11B, SLPI, ALPP
22ribonucleic acid4410.0RUNX2, CASR, GNAS, BMP2, PTH, SPP1
23neomycin4410.0ALPP, SPP1, BMP2, CASR
24titanium449.9RUNX2, TNFRSF11B, BMP2, SLPI, SPP1, ALPP
25sb 20358044 5910.9RUNX2, TNFRSF11B, BMP2, VDR, SPP1, ALPP
26alendronate44 49 1111.8RUNX2, TNFRSF11B, BMP2, VDR, SLPI, PTH
27ascorbic acid44 2410.7RUNX2, TNFRSF11B, BMP2, VDR, SLPI, SPP1
28cyclosporin a44 28 5911.7CASR, TNFRSF11B, BMP2, VDR, SLPI, SPP1
29sodium44 2410.7CASR, SFRP4, TNFRSF11B, SLPI, SLC34A1, SLC20A1
30clodronate44 49 1111.7SLPI, VDR, TNFRSF11B
31thymidine44 2410.7RUNX2, GNAS, BMP2, VDR, SLPI, PTH
32genistein44 28 59 2 11 2414.6ALPP, SPP1, SLPI, VDR, BMP2, TNFRSF11B
33testosterone44 59 11 2412.6TNFRSF11B, BMP2, VDR, SLPI, PTH, SPP1
34retinoid449.6RUNX2, BMP2, VDR, SPP1, ALPP
35magnesium44 11 2411.6CASR, TNFRSF11B, SLPI, PTH, SPP1, ALPP
36dexamethasone44 49 28 1112.6RUNX2, TNFRSF11B, BMP2, VDR, SLPI, PTH
37phosphorus449.5CASR, TNFRSF11B, VDR, FGF23, SLPI, SLC34A1
38hydroxyapatite449.5RUNX2, CASR, TNFRSF11B, BMP2, MGP, FGF23
39creatinine449.5CASR, TNFRSF11B, BMP2, VDR, FGF23, SLPI
40serine449.5RUNX2, CASR, GNAS, TNFRSF11B, BMP2, MGP
41arginine449.5CASR, GNAS, BMP2, VDR, FGF23, SLC20A1
4225-hydroxyvitamin d449.5SPP1, ALPP, PTH, SLPI, CASR, SFRP4
431,25 dihydroxy vitamin d3449.4RUNX2, CASR, TNFRSF11B, BMP2, VDR, FGF23
44retinoic acid44 2410.4RUNX2, TNFRSF11B, BMP2, MGP, VDR, SLPI
45cysteine449.4CASR, GNAS, TNFRSF11B, BMP2, VDR, SLPI
46vegf449.4RUNX2, TNFRSF11B, BMP2, SLPI, PTH, SPP1
47alanine449.3RUNX2, CASR, GNAS, BMP2, EMP1, VDR
48vitamin d449.1ALPP, SPP1, PTH, SLC34A1, RUNX2, CASR
49calcitriol44 59 11 2412.1CASR, SFRP4, TNFRSF11B, BMP2, MGP, VDR
50calcium44 49 11 2411.3BMP2, TNFRSF11B, GNAS, SFRP4, CASR, RUNX2

GO Terms for genes affiliated with Hyperphosphatemia

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16Gene Ontology
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Cellular components related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6TNFRSF11B, BMP2, FGF23, SLPI, SPP1, GNAS
2extracellular spaceGO:0056159.3SPP1, PTH, FGF23, BMP2, TNFRSF11B, SFRP4

Biological processes related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.4FGF23, VDR
2positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusGO:190152210.4RUNX2, BMP2
3phosphate ion homeostasisGO:05506210.3SLC34A1, FGF23, SFRP4
4regulation of odontogenesis of dentin-containing toothGO:04248710.2RUNX2, BMP2
5decidualizationGO:04669710.2SFRP4, VDR, SPP1
6osteoblast differentiationGO:00164910.2SPP1, BMP2, RUNX2
7cellular phosphate ion homeostasisGO:03064310.2GCM2, FGF23
8cellular response to BMP stimulusGO:07177310.2BMP2, RUNX2
9positive regulation of osteoblast differentiationGO:04566910.1BMP2, GNAS, RUNX2
10skeletal system developmentGO:00150110.1PTH, VDR, BMP2, TNFRSF11B
11cellular calcium ion homeostasisGO:00687410.1PTH, VDR, CASR, GCM2
12response to magnesium ionGO:03202610.1SLC34A1, TNFRSF11B
13ossificationGO:0015039.7MGP, CASR, RUNX2

Molecular functions related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.0ALPPL2, ALPP

Products for genes affiliated with Hyperphosphatemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperphosphatemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet