MCID: HYP025
MIFTS: 50

Hyperphosphatemia malady

Summaries for Hyperphosphatemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of... more...

MalaCards: Hyperphosphatemia is related to hyperostosis and calcinosis. An important gene associated with Hyperphosphatemia is FGF23 (fibroblast growth factor 23), and among its related pathways are Osteoclast Signaling and Vitamin D2 (ergocalciferol) metabolism. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and smooth muscle, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Hyperphosphatemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

hyperphosphatemia 8 10 44 60


External Ids:

Disease Ontology8 DOID:0050459
MeSH34 D054559

Related Diseases for Hyperphosphatemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperphosphatemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1hyperostosis30.6FGF23, GALNT3
2calcinosis30.6CASR, GALNT3, EMP1, FGF23, PTH, SPP1
3leukemia30.6RUNX2, BMP2, VDR, SLPI, SLC20A1, ALPP
4hyperparathyroidism30.6CASR, TNFRSF11B, EMP1, VDR, FGF23, SLPI
5peritonitis30.5SLPI
6hypercalcemia30.5PTH, ALPP, ALPPL2, SLPI, FGF23, CASR
7hyperphosphatemic familial tumoral calcinosis30.4GALNT3, FGF23
8uremia30.3CASR, TNFRSF11B, VDR, PTH, SPP1
9multiple myeloma30.3TNFRSF11B
10myeloma30.2TNFRSF11B, BMP2, SPP1, ALPP, ALPPL2
11hypophosphatemia30.2SFRP4, EMP1, VDR, FGF23, SLC34A1, PTH
12metabolic acidosis30.0PTH
13vascular disease30.0ALPPL2, ALPP, MGP
14hypertension29.8PTH
15hypoparathyroidism familial isolated29.8GCM2, CASR, PTH
16hypophosphatasia29.8ALPPL2, ALPP, SLPI
17pseudohypoparathyroidism type 1b29.8GNAS, STX16, PTH
18hypoparathyroidism29.8PTH, ALPP, FGF23, CASR, GCM2
19colorectal cancer29.8ALPPL2, ALPP, VDR, CASR
20kidney disease10.6
21hyperostosis-hyperphosphatemia syndrome10.4
22acute leukemia10.3
23lymphoblastic leukemia10.3
24lactic acidosis10.2
25burns10.0
26coronary stenosis10.0
27hypervitaminosis d10.0FGF23
28short stature10.0GNAS
29prostatitis10.0VDR
30obesity10.0GNAS
31keutel syndrome10.0MGP
32insulin resistance10.0GNAS
33ankylosis10.0BMP2
34sarcoidosis10.0ALPP
35hepatitis10.0ALPP
36mccune albright syndrome10.0GNAS, FGF23
37arteriosclerosis10.0SPP1, MGP
38hypophosphatemic rickets, autosomal dominant10.0FGF23, SFRP4
39leydig cell tumor10.0GNAS
40paget's disease of bone10.0ALPP, ALPPL2
41pituitary tumors10.0BMP2, GNAS
42pancreatic cancer10.0VDR, BMP2
43gingivitis10.0ALPP, TNFRSF11B
44root resorption10.0TNFRSF11B, BMP2
45goiter10.0PTH, GNAS
46hypercalciuria, absorptive10.0VDR, CASR
47diarrhea10.0ALPP, ALPPL2
48cystic fibrosis10.0SLPI, TNFRSF11B
49parathyroid carcinoma10.0PTH, CASR
50arthropathy10.0FGF23, BMP2, TNFRSF11B

Graphical network of the top 20 diseases related to Hyperphosphatemia:



Diseases related to hyperphosphatemia

Clinical Features for Hyperphosphatemia

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Drugs & Therapeutics for Hyperphosphatemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperphosphatemia

Drug clinical trials:

Search ClinicalTrials for Hyperphosphatemia

Search NIH Clinical Center for Hyperphosphatemia

Search CenterWatch for Hyperphosphatemia

Genetic Tests for Hyperphosphatemia

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Anatomical Context for Hyperphosphatemia

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32MalaCards
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MalaCards organs/tissues related to Hyperphosphatemia:

32
Kidney, Bone, Smooth muscle, Colon, Liver, Retina, Pituitary, T cells, Heart, Lung, Skin, Testes

Animal Models for Hyperphosphatemia or affiliated genes

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36MGI
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Publications for Hyperphosphatemia

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50PubMed
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Articles related to Hyperphosphatemia:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
Ferric Citrate Hydrate for the Treatment of Hyperphosphatemia in Nondialysis-Dependent CKD. (24408120)
2014
2
Chewability testing in the development of a chewable tablet for hyperphosphatemia. (24010939)
2013
3
A modeled economic evaluation of sevelamer for treatment of hyperphosphatemia associated with chronic kidney disease among patients on dialysis in the United Kingdom. (22857538)
2013
4
Adherence to phosphate binder therapy is the primary determinant of hyperphosphatemia incidence in patients receiving peritoneal dialysis. (23379497)
2013
5
Hyperphosphatemia is associated with overt proteinuria in non-diabetic patients with late-stage chronic kidney disease: a cross-sectional study. (22467089)
2013
6
Correction of hyperphosphatemia suppresses cardiac remodeling in uremic rats. (23740131)
2013
7
Cost-effectiveness of lanthanum carbonate in the treatment of hyperphosphatemia in dialysis patients: a Canadian payer perspective. (22742885)
2012
8
Prevention of systemic and regional haemodynamic alterations, hypercreatininemia, hyperuremia and hyperphosphatemia by losartan in hypertension with acute renal failure. (21388925)
2011
9
The control of hyperphosphatemia in chronic kidney disease: which phosphate binder? (19363781)
2009
10
Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. (19213845)
2009
11
Re: Enema-induced severe hyperphosphatemia in children. (19468749)
2009
12
Management of hyperphosphatemia in patients with end-stage renal disease: focus on lanthanum carbonate. (21694915)
2009
13
Fatal latrogenic hyperphosphatemia. (19192515)
2009
14
Effect of food additives on hyperphosphatemia among patients with end-stage renal disease: a randomized controlled trial. (19211470)
2009
15
Treatment options for hyperphosphatemia in feline CKD: what's out there? (19857854)
2009
16
Safety and effectiveness of nicotinic acid in the management of patients with chronic renal disease and hyperlipidemia associated to hyperphosphatemia]. (18336133)
2008
17
Niacin and related compounds for treating hyperphosphatemia in dialysis patients. (18363600)
2008
18
Hyperphosphatemia-induced hyperparathyroidism in 5/6 nephrectomized rats: development of a new animal model. (19102965)
2008
19
The challenge of hyperphosphatemia control in chronic kidney disease]. (18847412)
2008
20
Phosphate salivary secretion in hemodialysis patients: implications for the treatment of hyperphosphatemia. (17220638)
2007
21
The cost-effectiveness of lanthanum carbonate in the treatment of hyperphosphatemia in patients with end-stage renal disease. (17261114)
2007
22
Make your diagnosis. Multiple myeloma-associated with spurious hyperphosphatemia. (17914422)
2007
23
Clinical consequences and novel therapy of hyperphosphatemia: Lanthanum carbonate for dialysis patients. (18221100)
2007
24
Fatal hyperphosphatemia. (17198077)
2007
25
Controversies in the management of hyperphosphatemia in patients with end-stage renal disease. (16604944)
2006
26
Left ventricular hypertrophy: is hyperphosphatemia among dialysis patients a risk factor? (17130271)
2006
27
The role of daily dialysis in the control of hyperphosphatemia. (15882310)
2005
28
The clinical management of hyperphosphatemia. (16013007)
2005
29
Is lanthanum carbonate safer and more effective than calcium carbonate for hyperphosphatemia in dialysis patients? (16932360)
2005
30
Consequences and management of hyperphosphatemia in patients with renal insufficiency. (15882307)
2005
31
An introduction to phosphate binders for the treatment of hyperphosphatemia in patients with chronic kidney disease. (15954946)
2005
32
Hyperphosphatemia due to fosphenytoin in a pediatric ESRD patient. (15965770)
2005
33
Severe hyperphosphatemia and hypocalcemia following the rectal administration of a phosphate-containing Fleet pediatric enema. (15232246)
2004
34
Consequences of hyperphosphatemia in patients with end-stage renal disease (ESRD). (15296501)
2004
35
Treatment of hyperphosphatemia, secondary hyperparathyroidism and hypocalcemia with calcium carbonate favorably modulates vaccination response in uremic rats. (15224804)
2004
36
Severe hyperphosphatemia resulting from high-dose liposomal amphotericin in a child with leukemia. (12679649)
2003
37
New developments in hyperphosphatemia management. (12939384)
2003
38
Hyperphosphatemia in a burn patient. (11302608)
2001
39
Calcium acetate versus calcium carbonate in the control of hyperphosphatemia in hemodialysis patients. (11120549)
2000
40
Hyperphosphatemia: pharmacologic intervention yesterday, today and tomorrow. (11076107)
2000
41
Can pretransplantation hyperphosphatemia cause acute tubular necrosis in renal transplantation? (9838606)
1998
42
Severe hyperphosphatemia induced by a phosphate-containing oral laxative. (8835046)
1996
43
Extensive extraosseous localization of bone imaging agent in a patient with renal failure and rhabdomyolysis accompanied by combined hypercalcemia and hyperphosphatemia. (2544339)
1989
44
Cardiac arrest after acute hyperphosphatemia. (3406790)
1988
45
Elevated serum calcitriol concentrations do not fall in response to hyperphosphatemia in familial tumoral calcinosis. (3839626)
1985
46
Hyperphosphatemia: a factor that provokes severe experimental acute renal failure. (6212619)
1982
47
Acidosis, hypercalcemia, and hyperphosphatemia in rat fetuses near term and effects of maternal acid/base loading. (42076)
1979
48
Hyperphosphatemia and lactic acidosis. (271270)
1978
49
Tumoral calcinosis with hyperphosphatemia. A report of a family with incidence in four siblings. (5793850)
1969
50
Oral aluminium hydroxide in the treatment of hyperphosphatemia and acidosis in acute and chronic renal insufficiency. (14465480)
1962

Genetic Variations for Hyperphosphatemia

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Expression for genes affiliated with Hyperphosphatemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperphosphatemia

Search GEO for disease gene expression data for Hyperphosphatemia.

Pathways for genes affiliated with Hyperphosphatemia

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Hyperphosphatemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SPP1, TNFRSF11B
2
Vitamin D2 (ergocalciferol) metabolism
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10.2PTH, VDR
3
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10.2SLC34A1, SLC20A1
410.1PTH, FGF23, TNFRSF11B
510.1SPP1, FGF23, RUNX2
610.0ALPPL2, ALPP
79.9RUNX2, MGP, PTH, SPP1
8
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.7RUNX2, TNFRSF11B, VDR, PTH, SPP1
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.7SPP1, PTH, VDR, GNAS, RUNX2

Compounds for genes affiliated with Hyperphosphatemia

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1procollagen4410.7ALPP
2estrogen4410.6MGP, VDR
3deoxypyridinoline4410.4VDR, TNFRSF11B, PTH
4butyrate4410.4RUNX2, ALPPL2
5fibroin4410.4RUNX2, SPP1, BMP2
6cycloheximide4410.4ALPP, RUNX2, PTH
7polycaprolactone4410.3BMP2, ALPP, RUNX2
8foscarnet44 1111.3SPP1, SLC34A1, SLC20A1, RUNX2
922-oxacalcitriol4410.3ALPP, CASR, VDR
10pamidronate44 49 1112.2ALPP, CASR, TNFRSF11B, PTH
11etidronate4410.2TNFRSF11B, ALPP, SLPI
12zoledronic acid4410.1ALPP, TNFRSF11B, BMP2, SLPI
13raloxifene44 28 49 1113.1SLPI, VDR, BMP2, TNFRSF11B
14levamisole44 1111.1ALPPL2, SLPI, SPP1, ALPP
15vitamin k24410.1ALPP, TNFRSF11B, SLPI
16alizarin4410.1RUNX2, ALPP, SLPI, BMP2, SPP1
17hydroxyproline44 11 2412.1ALPP, PTH, SLPI, TNFRSF11B
18glucose4410.0PTH, SLPI, CASR, RUNX2
19tgf beta14410.0SPP1, BMP2, SLPI, TNFRSF11B, RUNX2
20chitosan4410.0ALPP, BMP2, SPP1
21risedronate44 59 49 28 1114.0ALPP, SLPI, TNFRSF11B
22ribonucleic acid4410.0RUNX2, GNAS, BMP2, PTH, CASR, SPP1
23neomycin4410.0CASR, BMP2, SPP1, ALPP
24titanium449.9BMP2, SPP1, ALPP, RUNX2, TNFRSF11B, SLPI
25sb 20358044 5910.9RUNX2, TNFRSF11B, ALPP, BMP2, SPP1, VDR
26alendronate44 49 1111.8TNFRSF11B, BMP2, VDR, SLPI, RUNX2, ALPP
27ascorbic acid44 2410.7TNFRSF11B, ALPP, SPP1, RUNX2, SLPI, VDR
28cyclosporin a44 28 5911.7CASR, TNFRSF11B, BMP2, VDR, SLPI, SPP1
29sodium44 2410.7CASR, TNFRSF11B, SLPI, SLC34A1, PTH, SLC20A1
30clodronate44 49 1111.7TNFRSF11B, SLPI, VDR
31thymidine44 2410.7ALPP, PTH, SLPI, BMP2, RUNX2, VDR
32genistein44 28 59 2 11 2414.6SLPI, ALPP, SPP1, TNFRSF11B, BMP2, VDR
33testosterone44 59 11 2412.6ALPP, BMP2, VDR, SLPI, PTH, SPP1
34retinoid449.6RUNX2, BMP2, VDR, SPP1, ALPP
35magnesium44 11 2411.6ALPPL2, ALPP, PTH, SLPI, TNFRSF11B, CASR
36dexamethasone44 49 28 1112.6PTH, SLPI, VDR, BMP2, TNFRSF11B, RUNX2
37phosphorus449.5FGF23, SLPI, SLC34A1, PTH, SPP1, CASR
38hydroxyapatite449.5SPP1, SLPI, FGF23, MGP, BMP2, TNFRSF11B
39creatinine449.5SPP1, TNFRSF11B, CASR, ALPP, VDR, FGF23
40serine449.5MGP, BMP2, TNFRSF11B, ALPP, RUNX2, CASR
41arginine449.5BMP2, GNAS, CASR, SLC20A1, PTH, SPP1
4225-hydroxyvitamin d449.5CASR, SLPI, FGF23, VDR, PTH, SPP1
431,25 dihydroxy vitamin d3449.5SLC34A1, FGF23, VDR, BMP2, TNFRSF11B, CASR
44retinoic acid44 2410.4RUNX2, BMP2, MGP, VDR, ALPP, SLPI
45cysteine449.4TNFRSF11B, CASR, GNAS, BMP2, VDR, SLPI
46vegf449.4TNFRSF11B, RUNX2, PTH, SPP1, ALPP, SLPI
47alanine449.3RUNX2, CASR, GNAS, BMP2, EMP1, VDR
48vitamin d449.1RUNX2, BMP2, MGP, VDR, FGF23, SLPI
49calcitriol44 59 11 2412.1SFRP4, SPP1, TNFRSF11B, BMP2, CASR, VDR
50calcium44 49 11 2411.3GCM2, RUNX2, CASR, SFRP4, FGF23, GNAS

GO Terms for genes affiliated with Hyperphosphatemia

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16Gene Ontology
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Cellular components related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6TNFRSF11B, BMP2, FGF23, SLPI, SPP1, GNAS
2extracellular spaceGO:0056159.3SPP1, PTH, FGF23, BMP2, TNFRSF11B, SFRP4

Biological processes related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.4FGF23, VDR
2positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusGO:190152210.4RUNX2, BMP2
3phosphate ion homeostasisGO:05506210.3SLC34A1, FGF23, SFRP4
4regulation of odontogenesis of dentin-containing toothGO:04248710.2RUNX2, BMP2
5decidualizationGO:04669710.2SFRP4, VDR, SPP1
6osteoblast differentiationGO:00164910.2SPP1, BMP2, RUNX2
7cellular phosphate ion homeostasisGO:03064310.2GCM2, FGF23
8cellular response to BMP stimulusGO:07177310.2BMP2, RUNX2
9positive regulation of osteoblast differentiationGO:04566910.1BMP2, GNAS, RUNX2
10skeletal system developmentGO:00150110.1PTH, VDR, BMP2, TNFRSF11B
11cellular calcium ion homeostasisGO:00687410.1PTH, VDR, CASR, GCM2
12response to magnesium ionGO:03202610.1SLC34A1, TNFRSF11B
13ossificationGO:0015039.7MGP, CASR, RUNX2

Molecular functions related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.0ALPPL2, ALPP

Products for genes affiliated with Hyperphosphatemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperphosphatemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet