MCID: HYP025
MIFTS: 48

Hyperphosphatemia malady

Summaries for Hyperphosphatemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of... more...

MalaCards: Hyperphosphatemia is related to hypercalcemia and hyperphosphatemic familial tumoral calcinosis. An important gene associated with Hyperphosphatemia is FGF23 (fibroblast growth factor 23), and among its related pathways are Osteoclast Signaling and Vitamin D2 (ergocalciferol) metabolism. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Hyperphosphatemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH
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Aliases & Descriptions:

hyperphosphatemia 8 10 45 61


External Ids:

Disease Ontology8 DOID:0050459
MeSH35 D054559

Related Diseases for Hyperphosphatemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hyperphosphatemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.5PTH, ALPP, ALPPL2, SLPI, FGF23, CASR
2hyperphosphatemic familial tumoral calcinosis30.4GALNT3, FGF23
3uremia30.4CASR, TNFRSF11B, VDR, PTH, SPP1
4hypophosphatemia30.3SFRP4, EMP1, VDR, FGF23, SLC34A1, PTH
5metabolic acidosis30.1PTH
6vascular disease30.1ALPPL2, ALPP, MGP
7hypoparathyroidism familial isolated29.9GCM2, CASR, PTH
8hypophosphatasia29.9ALPPL2, ALPP, SLPI
9pseudohypoparathyroidism type 1b29.9GNAS, STX16, PTH
10hypoparathyroidism29.9PTH, ALPP, FGF23, CASR, GCM2
11colorectal cancer29.8ALPPL2, ALPP, VDR, CASR
12hyperostosis-hyperphosphatemia syndrome10.5
13acute leukemia10.3
14familial tumoral calcinosis10.3
15n syndrome10.1
16hypertension10.0PTH
17hypervitaminosis d10.0FGF23
18peritonitis10.0SLPI
19multiple myeloma10.0TNFRSF11B
20short stature10.0GNAS
21prostatitis10.0VDR
22obesity10.0GNAS
23keutel syndrome10.0MGP
24hyperostosis10.0FGF23, GALNT3
25insulin resistance10.0GNAS
26ankylosis10.0BMP2
27sarcoidosis10.0ALPP
28hepatitis10.0ALPP
29mccune albright syndrome10.0GNAS, FGF23
30arteriosclerosis10.0SPP1, MGP
31hypophosphatemic rickets, autosomal dominant10.0FGF23, SFRP4
32leydig cell tumor10.0GNAS
33paget's disease of bone10.0ALPP, ALPPL2
34pituitary tumors10.0BMP2, GNAS
35pancreatic cancer10.0VDR, BMP2
36gingivitis10.0ALPP, TNFRSF11B
37root resorption10.0TNFRSF11B, BMP2
38goiter10.0PTH, GNAS
39hypercalciuria, absorptive10.0VDR, CASR
40diarrhea10.0ALPP, ALPPL2
41cystic fibrosis10.0SLPI, TNFRSF11B
42parathyroid carcinoma10.0PTH, CASR
43arthropathy10.0FGF23, BMP2, TNFRSF11B
44adenocarcinoma10.0SPP1, BMP2, CASR
45hypothyroidism10.0CASR, GNAS, PTH
46brachydactyly10.0PTH, GNAS, RUNX2
47aortic valve stenosis10.0SPP1, BMP2, TNFRSF11B
48inflammatory bowel disease10.0ALPPL2, ALPP
49sarcoma10.0SLPI, VDR, BMP2
50chondrosarcoma10.0BMP2, RUNX2

Graphical network of the top 20 diseases related to Hyperphosphatemia:



Diseases related to hyperphosphatemia

Clinical Features for Hyperphosphatemia

Drugs & Therapeutics for Hyperphosphatemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hyperphosphatemia

Drug clinical trials:

Search ClinicalTrials for Hyperphosphatemia

Search NIH Clinical Center for Hyperphosphatemia

Search CenterWatch for Hyperphosphatemia

Genetic Tests for Hyperphosphatemia

Anatomical Context for Hyperphosphatemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hyperphosphatemia:

33
Skin, Liver, Kidney, Lung, Retina, Heart, Smooth muscle, Colon, Salivary gland, T cells, B lymphoblasts, B cells, Pituitary

Animal Models for Hyperphosphatemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hyperphosphatemia

Sources:
51PubMed
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Articles related to Hyperphosphatemia:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
Effects and safety of lanthanum carbonate in end stage renal disease patients with hyperphosphatemia: a meta-analysis--system review of lanthanum carbonate. (23992043)
2013
2
Low calcium dialysate combined with CaCO3 in hyperphosphatemia in hemodialysis patients. (23837063)
2013
3
Use of nicotinamide to treat hyperphosphatemia in dialysis patients. (24000048)
2013
4
Correction of hypocalcemia allows optimal recruitment of FGF-23-dependent phosphaturic mechanisms in acute hyperphosphatemia post-phosphate enema. (23677707)
2013
5
A physiologic-based approach to the evaluation of a patient with hyperphosphatemia. (22938849)
2013
6
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells. (21719763)
2011
7
Prevention and control of phosphate retention/hyperphosphatemia in CKD-MBD: what is normal, when to start, and how to treat? (21292848)
2011
8
Hyperphosphatemia: understanding the role of phosphate metabolism. (20690439)
2010
9
Overexpression of parathyroid pituitary-specific transcription factor (Pit)-1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats. (20819513)
2010
10
One year efficacy and safety of lanthanum carbonate for hyperphosphatemia in Japanese chronic kidney disease patients undergoing hemodialysis. (20438515)
2010
11
Salivary phosphorus binding: a novel approach to control hyperphosphatemia. (19244574)
2009
12
Pathogenesis of bone and mineral related disorders in chronic kidney disease: key role of hyperphosphatemia. (19222729)
2009
13
Iron-magnesium hydroxycarbonate (fermagate): a novel non-calcium-containing phosphate binder for the treatment of hyperphosphatemia in chronic hemodialysis patients. (19158369)
2009
14
A case of familial tumoral calcinosis/hyperostosis-hyperphosphatemia syndrome due to a compound heterozygous mutation in GALNT3 demonstrating new phenotypic features. (18982401)
2009
15
Effect of lanthanum carbonate and calcium acetate in the treatment of hyperphosphatemia in patients of chronic kidney disease. (20523871)
2009
16
Extreme hyperphosphatemia and hypocalcemic coma associated with phosphate enema. (18379152)
2008
17
Liposomal amphotericin B associated with severe hyperphosphatemia. (18162947)
2008
18
The mechanisms of hyperphosphatemia-induced vascular calcification. (19115191)
2008
19
Should clinicians follow the K/DOQI guidelines for treating hyperphosphatemia with sevelamer? (17563773)
2007
20
Practical approaches to management of hyperphosphatemia: can we improve the current situation? (17170549)
2007
21
Hyperostosis-hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23. (17129170)
2007
22
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. (15590700)
2005
23
Treatment of hyperphosphatemia in hemodialysis patients: The Calcium Acetate Renagel Evaluation (CARE Study). (15086935)
2004
24
Treatment of hyperphosphatemia in patients with chronic kidney disease on maintenance hemodialysis: results of the CARE study. (15296505)
2004
25
The role of sevelamer in achieving the kidney disease outcomes quality initiative (K/DOQI) guidelines for hyperphosphatemia. (15265243)
2004
26
Hyperphosphatemia in multiple myeloma. (14667570)
2003
27
Hyperphosphatemia in dialysis patients: is there a role for focused counseling? (12874747)
2003
28
The renal dietitian's role in managing hyperphosphatemia and secondary hyperparathyroidism in dialysis patients: a national survey. (12671837)
2003
29
Symptoms of hyperphosphatemia, hypocalcemia, and hypomagnesemia in an adolescent after the oral administration of sodium phosphate in preparation for a colonoscopy. (11323597)
2001
30
A comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients. (10196011)
1999
31
Hypocalcemia and hyperphosphatemia due to primary hypoparathyroidism in a six-month-old kitten. (9826287)
1998
32
Inhibition of gastric secretion by omeprazole and efficiency of calcium carbonate on the control of hyperphosphatemia in patients on chronic hemodialysis. (9684693)
1998
33
Fatal hyperphosphatemia after oral phosphate overdose in a premature infant. (9359956)
1997
34
Severe hyperphosphatemia following phosphate administration for bowel preparation in patients with renal failure: two cases and a review of the literature. (9002537)
1997
35
Prevent hyperphosphatemia in a child on hemodialysis. (9323304)
1997
36
Alkali therapy, hyperphosphatemia, and acute tumor lysis syndrome. (7494519)
1996
37
Hyperphosphatemia: an objective marker for bulimia nervosa? (7648849)
1995
38
Severe hyperphosphatemia following acute tumor lysis syndrome. (7968798)
1995
39
Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger. (1339166)
1992
40
Hyperphosphatemia in multiple myeloma due to a phosphate-binding immunoglobulin. (1913479)
1991
41
Calcium carbonate in hyperphosphatemia. (1949973)
1991
42
Severe hyperphosphatemia associated with tumor lysis in a patient with T-cell leukemia. (2602196)
1989
43
Hyperphosphatemia and hypocalcemic coma associated with phosphate enema. (4049045)
1985
44
Acute renal failure caused by extreme hyperphosphatemia after chemotherapy of an acute lymphoblastic leukemia. (6585264)
1984
45
The "anemia" of childhood: evidence for a physiologic response to hyperphosphatemia. (4684041)
1973
46
A magnesium-deficient patient presenting with hypocalcemia and hyperphosphatemia. (4721178)
1973
47
Editorial: Hyperphosphatemia, hyperparathyroidism and bighead. (4753034)
1973
48
Cortical hyperostosis with hyperphosphatemia. (5116713)
1971
49
Acute induction of soft tissue calcification with transient hyperphosphatemia in the KK mouse by modification in dietary contents of calcium, phosphorus, and magnesium. (5439348)
1970
50
Heterotopic calcification, hyperphosphatemia and angioid streaks of the retina. (13774168)
1961

Genetic Variations for Hyperphosphatemia

Expression for genes affiliated with Hyperphosphatemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperphosphatemia

Search GEO for disease gene expression data for Hyperphosphatemia.

Pathways for genes affiliated with Hyperphosphatemia

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Hyperphosphatemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SPP1, TNFRSF11B
2
Vitamin D2 (ergocalciferol) metabolism
Hide members
10.2PTH, VDR
3
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10.2SLC34A1, SLC20A1
410.1PTH, FGF23, TNFRSF11B
510.1SPP1, FGF23, RUNX2
610.0ALPPL2, ALPP
79.9RUNX2, MGP, PTH, SPP1
8
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.7RUNX2, TNFRSF11B, VDR, PTH, SPP1
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.7SPP1, PTH, VDR, GNAS, RUNX2

Compounds for genes affiliated with Hyperphosphatemia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1procollagen4510.7ALPP
2estrogen4510.6VDR, MGP
3deoxypyridinoline4510.4PTH, VDR, TNFRSF11B
4butyrate4510.4ALPPL2, RUNX2
5fibroin4510.4SPP1, BMP2, RUNX2
6cycloheximide4510.4ALPP, PTH, RUNX2
7polycaprolactone4510.3RUNX2, BMP2, ALPP
8foscarnet45 1111.3RUNX2, SLC34A1, SLC20A1, SPP1
922-oxacalcitriol4510.3ALPP, VDR, CASR
10pamidronate45 50 1112.2CASR, TNFRSF11B, PTH, ALPP
11etidronate4510.2TNFRSF11B, SLPI, ALPP
12zoledronic acid4510.1TNFRSF11B, BMP2, SLPI, ALPP
13raloxifene45 29 50 1113.1TNFRSF11B, BMP2, VDR, SLPI
14levamisole45 1111.1SLPI, SPP1, ALPP, ALPPL2
15vitamin k24510.1TNFRSF11B, SLPI, ALPP
16alizarin4510.1RUNX2, BMP2, SLPI, SPP1, ALPP
17hydroxyproline45 11 2412.1TNFRSF11B, SLPI, PTH, ALPP
18glucose4510.0RUNX2, CASR, SLPI, PTH
19tgf beta14510.0SPP1, SLPI, BMP2, TNFRSF11B, RUNX2
20chitosan4510.0ALPP, SPP1, BMP2
21risedronate45 60 50 29 1114.0TNFRSF11B, SLPI, ALPP
22ribonucleic acid4510.0RUNX2, CASR, GNAS, BMP2, PTH, SPP1
23neomycin4510.0ALPP, SPP1, BMP2, CASR
24titanium459.9RUNX2, TNFRSF11B, BMP2, SLPI, SPP1, ALPP
25sb 20358045 6010.9RUNX2, TNFRSF11B, BMP2, VDR, SPP1, ALPP
26alendronate45 50 1111.8RUNX2, TNFRSF11B, BMP2, VDR, SLPI, PTH
27ascorbic acid45 2410.7RUNX2, TNFRSF11B, BMP2, VDR, SLPI, SPP1
28cyclosporin a45 29 6011.7CASR, TNFRSF11B, BMP2, VDR, SLPI, SPP1
29sodium45 2410.7CASR, SFRP4, TNFRSF11B, SLPI, SLC34A1, SLC20A1
30clodronate45 50 1111.7SLPI, VDR, TNFRSF11B
31thymidine45 2410.7RUNX2, GNAS, BMP2, VDR, SLPI, PTH
32genistein45 29 60 2 11 2414.6ALPP, SPP1, SLPI, VDR, BMP2, TNFRSF11B
33testosterone45 60 11 2412.6TNFRSF11B, BMP2, VDR, SLPI, PTH, SPP1
34retinoid459.6RUNX2, BMP2, VDR, SPP1, ALPP
35magnesium45 11 2411.6CASR, TNFRSF11B, SLPI, PTH, SPP1, ALPP
36dexamethasone45 50 29 1112.6RUNX2, TNFRSF11B, BMP2, VDR, SLPI, PTH
37phosphorus459.5CASR, TNFRSF11B, VDR, FGF23, SLPI, SLC34A1
38hydroxyapatite459.5RUNX2, CASR, TNFRSF11B, BMP2, MGP, FGF23
39creatinine459.5CASR, TNFRSF11B, BMP2, VDR, FGF23, SLPI
40serine459.5RUNX2, CASR, GNAS, TNFRSF11B, BMP2, MGP
41arginine459.5CASR, GNAS, BMP2, VDR, FGF23, SLC20A1
4225-hydroxyvitamin d459.5SPP1, ALPP, PTH, SLPI, CASR, SFRP4
431,25 dihydroxy vitamin d3459.4RUNX2, CASR, TNFRSF11B, BMP2, VDR, FGF23
44retinoic acid45 2410.4RUNX2, TNFRSF11B, BMP2, MGP, VDR, SLPI
45cysteine459.4CASR, GNAS, TNFRSF11B, BMP2, VDR, SLPI
46vegf459.4RUNX2, TNFRSF11B, BMP2, SLPI, PTH, SPP1
47alanine459.3RUNX2, CASR, GNAS, BMP2, EMP1, VDR
48vitamin d459.1ALPP, SPP1, PTH, SLC34A1, RUNX2, CASR
49calcitriol45 60 11 2412.1CASR, SFRP4, TNFRSF11B, BMP2, MGP, VDR
50calcium45 50 11 2411.3BMP2, TNFRSF11B, GNAS, SFRP4, CASR, RUNX2

GO Terms for genes affiliated with Hyperphosphatemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6TNFRSF11B, BMP2, FGF23, SLPI, SPP1, GNAS
2extracellular spaceGO:0056159.3SPP1, PTH, FGF23, BMP2, TNFRSF11B, SFRP4

Biological processes related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.4FGF23, VDR
2positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusGO:190152210.4RUNX2, BMP2
3phosphate ion homeostasisGO:05506210.3SLC34A1, FGF23, SFRP4
4regulation of odontogenesis of dentin-containing toothGO:04248710.2RUNX2, BMP2
5decidualizationGO:04669710.2SFRP4, VDR, SPP1
6osteoblast differentiationGO:00164910.2SPP1, BMP2, RUNX2
7cellular phosphate ion homeostasisGO:03064310.2GCM2, FGF23
8cellular response to BMP stimulusGO:07177310.2BMP2, RUNX2
9positive regulation of osteoblast differentiationGO:04566910.1BMP2, GNAS, RUNX2
10skeletal system developmentGO:00150110.1PTH, VDR, BMP2, TNFRSF11B
11cellular calcium ion homeostasisGO:00687410.1PTH, VDR, CASR, GCM2
12response to magnesium ionGO:03202610.1SLC34A1, TNFRSF11B
13ossificationGO:0015039.7MGP, CASR, RUNX2

Molecular functions related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.0ALPPL2, ALPP

Products for genes affiliated with Hyperphosphatemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperphosphatemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet