MCID: HYP025
MIFTS: 36

Hyperphosphatemia malady

Summaries for Hyperphosphatemia

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Wikipedia:63 Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of... more...

MalaCards based summary: Hyperphosphatemia is related to tumoral calcinosis, hyperphosphatemic, familial and hyperostosis. An important gene associated with Hyperphosphatemia is FGF23 (fibroblast growth factor 23), and among its related pathways are FGF signaling pathway and Osteoblast Signaling. The compounds foscarnet and procollagen have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and smooth muscle, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Aliases & Classifications for Hyperphosphatemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH
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Hyperphosphatemia, Aliases & Descriptions:

Name: Hyperphosphatemia 9 11 43 60


External Ids:

Disease Ontology9 DOID:0050459
MeSH33 D054559

Related Diseases for Hyperphosphatemia

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Diseases related to Hyperphosphatemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1tumoral calcinosis, hyperphosphatemic, familial31.1GALNT3, FGF23
2hyperostosis31.1FGF23, GALNT3
3familial tumoral calcinosis30.8GALNT3, FGF23
4kidney disease30.7FGF23, MGP, SPP1
5hyperparathyroidism30.7FGF23, PTH
6calcinosis30.4FGF23, GALNT3, PTH, SPP1
7uremia30.3SPP1, PTH
8hypoparathyroidism30.3PTH, FGF23
9hypercalcemia30.3MGP, PTH, FGF23
10hypophosphatemia30.3SLC34A1, PTH, FGF23
11leukemia10.5
12peritonitis10.5
13hypervitaminosis d10.4FGF23
14lymphoblastic leukemia10.3
15multiple myeloma10.3
16lactic acidosis10.3
17myeloma10.3
18blindness10.3
19hypophosphatemic rickets, x-linked dominant10.2FGF23, SLC34A1
20rickets10.2PTH, FGF23
21renal osteodystrophy10.1PTH, FGF23
22nephrocalcinosis10.1SPP1, SLC34A1
23primary hyperparathyroidism10.1PTH, FGF23
24hypoparathyroidism-retardation-dysmorphism syndrome10.1
25hypoparathyroidism, familial isolated10.1
26pseudohypoparathyroidism, type ib10.1
27hypocalcemia, autosomal dominant10.1
28burns10.1
29metabolic acidosis10.1
30secondary hyperparathyroidism of renal origin10.1FGF23, PTH
31osteomalacia10.1PTH, FGF23
32hyperthyroidism10.0FGF23, PTH
33colorectal cancer9.9
34paget disease, juvenile9.9
35hyperphosphatasia with mental retardation syndrome 39.9
36malignant hyperthermia susceptibility 19.9
37pseudohypoparathyroidism ia9.9
38pseudohypoparathyroidism ic9.9
39acute leukemia9.9
40chronic lymphocytic leukemia9.9
41liver disease9.9
42jejunoileitis9.9
43neuronitis9.9
44intussusception9.9
45angioid streaks9.9
46cushing's syndrome9.9
47gastroschisis9.9
48bulimia nervosa9.9
49calciphylaxis9.9
50hypophosphatasia9.9

Graphical network of the top 20 diseases related to Hyperphosphatemia:



Diseases related to hyperphosphatemia

Symptoms for Hyperphosphatemia

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Drugs & Therapeutics for Hyperphosphatemia

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Drug clinical trials:

Search ClinicalTrials for Hyperphosphatemia

Search NIH Clinical Center for Hyperphosphatemia

Genetic Tests for Hyperphosphatemia

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Anatomical Context for Hyperphosphatemia

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MalaCards organs/tissues related to Hyperphosphatemia:

31
Kidney, Bone, Smooth muscle, Colon, Liver, Retina, Heart, Lung, Testes, T cells, Endothelial, Cardiac myocytes, Pituitary

Animal Models for Hyperphosphatemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperphosphatemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0GALNT3, PTH, FGF23
2MP:00053898.5FGF23, SLC34A1, GALNT3, SPP1
3MP:00053677.9FGF23, SPP1, SLC34A1, GALNT3, MGP
4MP:00053857.6PTH, FGF23, GALNT3, SPP1, MGP
5MP:00053907.3MGP, SPP1, FGF23, SLC34A1, GALNT3, PTH
6MP:00107687.3FGF23, PTH, SPP1, MGP, SLC34A1
7MP:00053787.2SPP1, MGP, PTH, GALNT3, SLC34A1, FGF23
8MP:00053767.2GALNT3, SPP1, MGP, PTH, SLC34A1, FGF23

Publications for Hyperphosphatemia

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Articles related to Hyperphosphatemia:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Survival advantage of lanthanum carbonate for hemodialysis patients with uncontrolled hyperphosphatemia. (25422311)
2015
2
Niacin as a drug repositioning candidate for hyperphosphatemia management in dialysis patients. (25342908)
2014
3
Hyperostosis-hyperphosphatemia syndrome (HHS): report of two cases with a recurrent mutation and review of the literature. (25153226)
2014
4
Dose-finding study of bixalomer in patients with chronic kidney disease on hemodialysis with hyperphosphatemia: a double-blind, randomized, placebo-controlled and sevelamer hydrochloride-controlled open-label, parallel group study. (24975892)
2014
5
JTT-751 for Treatment of Patients with Hyperphosphatemia on Peritoneal Dialysis. (25401266)
2014
6
Severe vascular calcification and tumoral calcinosis in a family with hyperphosphatemia: a fibroblast growth factor 23 mutation identified by exome sequencing. (25378588)
2014
7
Immobilization-induced hyperphosphatemia and functional hypoparathyroidism successfully treated with oral bisphosphonates. (24992393)
2014
8
Effects and safety of lanthanum carbonate in end stage renal disease patients with hyperphosphatemia: a meta-analysis--system review of lanthanum carbonate. (23992043)
2013
9
Severe hyperphosphatemia in a patient with chronic kidney disease and multiple myeloma-to strengthen the case toward renal replacement therapy? (25356216)
2013
10
Long-term treatment of hyperphosphatemia with bixalomer in Japanese hemodialysis patients. (24330556)
2013
11
Dose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. (23369827)
2013
12
The management of hyperphosphatemia by lanthanum carbonate in chronic kidney disease patients. (22723728)
2012
13
A 90-year-old man with hyperphosphatemia. (20951488)
2011
14
Safety and efficacy of nicotinamide in the management of hyperphosphatemia in patients on hemodialysis. (22022084)
2011
15
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells. (21719763)
2011
16
Reduction of hyperphosphatemia is related with the reduction of C-reactive protein in dialysis patients. Study in sevelamer-resistant dialysis patients treated with chitosan chewing gum as salivary phosphate binder. (21219199)
2011
17
Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)
2009
18
Salivary phosphorus binding: a novel approach to control hyperphosphatemia. (19244574)
2009
19
Efficacy of hyperphosphatemia control in the progression of chronic renal failure and the prevalence of cardiovascular calcification. (19203546)
2009
20
Treatment of hyperphosphatemia with sevelamer hydrochloride in dialysis patients: effects on vascular calcification, bone and a close look into the survival data. (19034324)
2008
21
Hyperphosphatemia and its treatment. 1983. (19010018)
2008
22
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. (16985213)
2007
23
Phosphate salivary secretion in hemodialysis patients: implications for the treatment of hyperphosphatemia. (17220638)
2007
24
Management of hyperphosphatemia. (17014508)
2006
25
Hyperphosphatemia and phosphate binders. (16278327)
2005
26
Tumoral calcinosis with hyperphosphatemia. (16272668)
2005
27
Treatment of hyperphosphatemia in patients with chronic kidney disease on maintenance hemodialysis. (15882308)
2005
28
Severe hyperphosphatemia and hypocalcemia following the rectal administration of a phosphate-containing Fleet pediatric enema. (15232246)
2004
29
Consequences of hyperphosphatemia in patients with end-stage renal disease (ESRD). (15296501)
2004
30
Dietary habits and counseling focused on phosphate intake in hemodialysis patients with hyperphosphatemia. (15483782)
2004
31
FGF-23 is elevated by chronic hyperphosphatemia. (15356053)
2004
32
Hyperphosphatemia in multiple myeloma. (14667570)
2003
33
Calcium acetate versus calcium carbonate in the control of hyperphosphatemia in hemodialysis patients. (11120549)
2000
34
A randomized trial of sevelamer hydrochloride (RenaGel) with and without supplemental calcium. Strategies for the control of hyperphosphatemia and hyperparathyroidism in hemodialysis patients. (9988142)
1999
35
Hypocalcemia and hyperphosphatemia due to primary hypoparathyroidism in a six-month-old kitten. (9826287)
1998
36
Hyperphosphatemia associated with phosphorus-containing laxatives in a patient with chronic renal insufficiency. (9042182)
1997
37
Review of the literature: severe hyperphosphatemia. (7573122)
1995
38
Hyperphosphatemia: an objective marker for bulimia nervosa? (7648849)
1995
39
Hyperphosphatemia in multiple myeloma due to a phosphate-binding immunoglobulin. (1913479)
1991
40
Hyperphosphatemia in infantile hypophosphatasia: implications for carrier diagnosis and screening. (2301398)
1990
41
Extensive extraosseous localization of bone imaging agent in a patient with renal failure and rhabdomyolysis accompanied by combined hypercalcemia and hyperphosphatemia. (2544339)
1989
42
Management of hyperphosphatemia with calcium citrate in hemodialysis patients. (2710274)
1989
43
Intense pyrophosphate heart and lung uptake in a patient with marked hyperphosphatemia. (6321078)
1984
44
Acute renal failure caused by extreme hyperphosphatemia after chemotherapy of an acute lymphoblastic leukemia. (6585264)
1984
45
Enema-induced hypocalcemia and hyperphosphatemia leading to cardiac arrest during induction of anesthesia in an outpatient surgery center. (6650917)
1983
46
Hyperphosphatemia and hypocalcemia in lemurs. (104937)
1978
47
The "anemia" of childhood: evidence for a physiologic response to hyperphosphatemia. (4684041)
1973
48
Sudden death after phosphorus burns: experimental observations of hypocalcemia, hyperphosphatemia and electrocardiographic abnormalities following production of a standard white phosphorus burn. (5113459)
1971
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Oral aluminium hydroxide in the treatment of hyperphosphatemia and acidosis in acute and chronic renal insufficiency. (14465480)
1962

Variations for Hyperphosphatemia

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Expression for genes affiliated with Hyperphosphatemia

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Search GEO for disease gene expression data for Hyperphosphatemia.

Pathways for genes affiliated with Hyperphosphatemia

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Pathways related to Hyperphosphatemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5FGF23, SPP1
29.4FGF23, PTH
39.3SPP1, PTH
49.3SPP1, PTH
58.5SPP1, PTH, MGP

Compounds for genes affiliated with Hyperphosphatemia

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Compounds related to Hyperphosphatemia according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1foscarnet43 1210.5SLC34A1, SPP1
2procollagen439.2PTH, SPP1
3gamma-carboxyglutamic acid439.2MGP, SPP1
425-hydroxyvitamin d439.1FGF23, SPP1, PTH
5creatinine438.9SPP1, PTH, FGF23
6hydroxyapatite438.9SPP1, FGF23, MGP
7phosphorus438.7SPP1, FGF23, SLC34A1, PTH
81,25 dihydroxy vitamin d3438.6SLC34A1, SPP1, FGF23, PTH
9arginine438.6PTH, SPP1, FGF23
10estrogen438.5SPP1, MGP, PTH
11calcitriol43 59 24 1210.8FGF23, SLC34A1, PTH, MGP, SPP1
12vitamin d437.8MGP, FGF23, PTH, SPP1, SLC34A1
13calcium43 49 24 1210.3SPP1, GALNT3, PTH, MGP, FGF23, SLC34A1

GO Terms for genes affiliated with Hyperphosphatemia

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Cellular components related to Hyperphosphatemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.9FGF23, PTH, SPP1
2perinuclear region of cytoplasmGO:00484718.7SLC34A1, GALNT3, SPP1

Biological processes related to Hyperphosphatemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:00550629.6SLC34A1, FGF23
2response to lead ionGO:00102889.3SLC34A1, PTH
3response to vitamin DGO:00332809.2SPP1, PTH
4ossificationGO:00015039.1MGP, SLC34A1
5response to cadmium ionGO:00466869.0SLC34A1, PTH

Products for genes affiliated with Hyperphosphatemia

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Sources for Hyperphosphatemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet