MCID: HYP025
MIFTS: 43

Hyperphosphatemia malady

Metabolic diseases category
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Summaries for Hyperphosphatemia

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Wikipedia:65 Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of... more...

MalaCards based summary: Hyperphosphatemia is related to hyperostosis and hyperphosphatemic familial tumoral calcinosis. An important gene associated with Hyperphosphatemia is FGF23 (fibroblast growth factor 23), and among its related pathways are FGF signaling pathway and Osteoblast Signaling. The compounds foscarnet and procollagen have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and smooth muscle, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Aliases & Classifications for Hyperphosphatemia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH
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Hyperphosphatemia, Aliases & Descriptions:

Name: Hyperphosphatemia 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:0050459
MeSH34 D054559

Related Diseases for Hyperphosphatemia

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Diseases related to Hyperphosphatemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1hyperostosis31.1GALNT3, FGF23
2hyperphosphatemic familial tumoral calcinosis31.0GALNT3, FGF23
3hyperparathyroidism30.7FGF23, PTH
4calcinosis30.4FGF23, GALNT3, PTH, SPP1
5uremia30.3SPP1, PTH
6hypoparathyroidism30.3FGF23, PTH
7hypercalcemia30.3FGF23, PTH, MGP
8hypophosphatemia30.3PTH, SLC34A1, FGF23
9kidney disease10.6
10hyperostosis-hyperphosphatemia syndrome10.6
11leukemia10.5
12peritonitis10.5
13hypervitaminosis d10.4FGF23
14lymphoblastic leukemia10.3
15acute lymphoblastic leukemia10.3
16multiple myeloma10.3
17lactic acidosis10.3
18myeloma10.3
19familial tumoral calcinosis10.3
20blindness10.3
21x-linked hypophosphatemia10.2SLC34A1, FGF23
22rickets10.2FGF23, PTH
23renal osteodystrophy10.1FGF23, PTH
24nephrocalcinosis10.1SLC34A1, SPP1
25primary hyperparathyroidism10.1PTH, FGF23
26burns10.1
27metabolic acidosis10.1
28secondary hyperparathyroidism of renal origin10.1PTH, FGF23
29osteomalacia10.1FGF23, PTH
30hyperthyroidism10.0FGF23, PTH
31acute leukemia9.9
32chronic lymphocytic leukemia9.9
33colorectal cancer9.9
34hypertension9.9
35liver disease9.9
36hypophosphatasia9.9
37angioid streaks9.9
38cushing's syndrome9.9
39bulimia nervosa9.9
40calciphylaxis9.9
41jejunoileitis9.9
42neuronitis9.9
43intussusception9.9
44gastroschisis9.9
45nephrotic syndrome9.9
46proteinuria9.9
47t-cell leukemia9.9
48hypoparathyroidism familial isolated9.9
49pseudohypoparathyroidism type 1b9.9
50headache9.9

Graphical network of the top 20 diseases related to Hyperphosphatemia:



Diseases related to hyperphosphatemia

Symptoms for Hyperphosphatemia

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Drugs & Therapeutics for Hyperphosphatemia

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Drug clinical trials:

Search ClinicalTrials for Hyperphosphatemia

Search NIH Clinical Center for Hyperphosphatemia

Genetic Tests for Hyperphosphatemia

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Anatomical Context for Hyperphosphatemia

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MalaCards organs/tissues related to Hyperphosphatemia:

32
Kidney, Bone, Smooth muscle, Colon, Liver, Retina, Heart, Lung, Skin, Testes, T cells, Cardiac myocytes, Pituitary

Animal Models for Hyperphosphatemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperphosphatemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0FGF23, GALNT3, PTH
2MP:00053898.5SPP1, GALNT3, SLC34A1, FGF23
3MP:00053677.9SPP1, MGP, GALNT3, SLC34A1, FGF23
4MP:00053857.6SPP1, MGP, PTH, GALNT3, FGF23
5MP:00053907.3FGF23, SLC34A1, GALNT3, PTH, MGP, SPP1
6MP:00107687.3SPP1, MGP, PTH, SLC34A1, FGF23
7MP:00053787.2SPP1, MGP, PTH, GALNT3, SLC34A1, FGF23
8MP:00053767.2SPP1, MGP, PTH, GALNT3, SLC34A1, FGF23

Publications for Hyperphosphatemia

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Articles related to Hyperphosphatemia:

(show top 50)    (show all 378)
idTitleAuthorsYear
1
Niacin as a drug repositioning candidate for hyperphosphatemia management in dialysis patients. (25342908)
2014
2
Hyperostosis-hyperphosphatemia syndrome (HHS): report of two cases with a recurrent mutation and review of the literature. (25153226)
2014
3
Dose-finding study of bixalomer in patients with chronic kidney disease on hemodialysis with hyperphosphatemia: a double-blind, randomized, placebo-controlled and sevelamer hydrochloride-controlled open-label, parallel group study. (24975892)
2014
4
JTT-751 for Treatment of Patients with Hyperphosphatemia on Peritoneal Dialysis. (25401266)
2014
5
Severe vascular calcification and tumoral calcinosis in a family with hyperphosphatemia: a fibroblast growth factor 23 mutation identified by exome sequencing. (25378588)
2014
6
Immobilization-induced hyperphosphatemia and functional hypoparathyroidism successfully treated with oral bisphosphonates. (24992393)
2014
7
Effects and safety of lanthanum carbonate in end stage renal disease patients with hyperphosphatemia: a meta-analysis--system review of lanthanum carbonate. (23992043)
2013
8
Severe hyperphosphatemia in a patient with chronic kidney disease and multiple myeloma-to strengthen the case toward renal replacement therapy? (25356216)
2013
9
Long-term treatment of hyperphosphatemia with bixalomer in Japanese hemodialysis patients. (24330556)
2013
10
Dose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. (23369827)
2013
11
The management of hyperphosphatemia by lanthanum carbonate in chronic kidney disease patients. (22723728)
2012
12
A 90-year-old man with hyperphosphatemia. (20951488)
2011
13
Safety and efficacy of nicotinamide in the management of hyperphosphatemia in patients on hemodialysis. (22022084)
2011
14
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells. (21719763)
2011
15
Reduction of hyperphosphatemia is related with the reduction of C-reactive protein in dialysis patients. Study in sevelamer-resistant dialysis patients treated with chitosan chewing gum as salivary phosphate binder. (21219199)
2011
16
Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. (19297793)
2009
17
Salivary phosphorus binding: a novel approach to control hyperphosphatemia. (19244574)
2009
18
Efficacy of hyperphosphatemia control in the progression of chronic renal failure and the prevalence of cardiovascular calcification. (19203546)
2009
19
Treatment of hyperphosphatemia with sevelamer hydrochloride in dialysis patients: effects on vascular calcification, bone and a close look into the survival data. (19034324)
2008
20
Hyperphosphatemia and its treatment. 1983. (19010018)
2008
21
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. (16985213)
2007
22
Phosphate salivary secretion in hemodialysis patients: implications for the treatment of hyperphosphatemia. (17220638)
2007
23
Management of hyperphosphatemia. (17014508)
2006
24
Hyperphosphatemia and phosphate binders. (16278327)
2005
25
Tumoral calcinosis with hyperphosphatemia. (16272668)
2005
26
Treatment of hyperphosphatemia in patients with chronic kidney disease on maintenance hemodialysis. (15882308)
2005
27
Severe hyperphosphatemia and hypocalcemia following the rectal administration of a phosphate-containing Fleet pediatric enema. (15232246)
2004
28
Consequences of hyperphosphatemia in patients with end-stage renal disease (ESRD). (15296501)
2004
29
Dietary habits and counseling focused on phosphate intake in hemodialysis patients with hyperphosphatemia. (15483782)
2004
30
FGF-23 is elevated by chronic hyperphosphatemia. (15356053)
2004
31
Hyperphosphatemia in multiple myeloma. (14667570)
2003
32
Calcium acetate versus calcium carbonate in the control of hyperphosphatemia in hemodialysis patients. (11120549)
2000
33
A randomized trial of sevelamer hydrochloride (RenaGel) with and without supplemental calcium. Strategies for the control of hyperphosphatemia and hyperparathyroidism in hemodialysis patients. (9988142)
1999
34
Hypocalcemia and hyperphosphatemia due to primary hypoparathyroidism in a six-month-old kitten. (9826287)
1998
35
Hyperphosphatemia associated with phosphorus-containing laxatives in a patient with chronic renal insufficiency. (9042182)
1997
36
Review of the literature: severe hyperphosphatemia. (7573122)
1995
37
Hyperphosphatemia: an objective marker for bulimia nervosa? (7648849)
1995
38
Hyperphosphatemia in multiple myeloma due to a phosphate-binding immunoglobulin. (1913479)
1991
39
Hyperphosphatemia in infantile hypophosphatasia: implications for carrier diagnosis and screening. (2301398)
1990
40
Extensive extraosseous localization of bone imaging agent in a patient with renal failure and rhabdomyolysis accompanied by combined hypercalcemia and hyperphosphatemia. (2544339)
1989
41
Management of hyperphosphatemia with calcium citrate in hemodialysis patients. (2710274)
1989
42
The role of metabolic acidosis in causing uremic hyperphosphatemia. (3007964)
1986
43
Intense pyrophosphate heart and lung uptake in a patient with marked hyperphosphatemia. (6321078)
1984
44
Acute renal failure caused by extreme hyperphosphatemia after chemotherapy of an acute lymphoblastic leukemia. (6585264)
1984
45
Enema-induced hypocalcemia and hyperphosphatemia leading to cardiac arrest during induction of anesthesia in an outpatient surgery center. (6650917)
1983
46
Hyperphosphatemia and hypocalcemia in lemurs. (104937)
1978
47
The "anemia" of childhood: evidence for a physiologic response to hyperphosphatemia. (4684041)
1973
48
Sudden death after phosphorus burns: experimental observations of hypocalcemia, hyperphosphatemia and electrocardiographic abnormalities following production of a standard white phosphorus burn. (5113459)
1971
49
Cortical hyperostosis with hyperphosphatemia: a new syndrome? (5486638)
1970
50
Oral aluminium hydroxide in the treatment of hyperphosphatemia and acidosis in acute and chronic renal insufficiency. (14465480)
1962

Variations for Hyperphosphatemia

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Expression for genes affiliated with Hyperphosphatemia

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Expression patterns in normal tissues for genes affiliated with Hyperphosphatemia

Search GEO for disease gene expression data for Hyperphosphatemia.

Pathways for genes affiliated with Hyperphosphatemia

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Pathways related to Hyperphosphatemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5FGF23, SPP1
29.4FGF23, PTH
39.3SPP1, PTH
49.3PTH, SPP1
58.5PTH, MGP, SPP1

Compounds for genes affiliated with Hyperphosphatemia

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Compounds related to Hyperphosphatemia according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1foscarnet44 1110.5SLC34A1, SPP1
2procollagen449.2PTH, SPP1
3gamma-carboxyglutamic acid449.2MGP, SPP1
425-hydroxyvitamin d449.1SPP1, PTH, FGF23
5creatinine448.9SPP1, PTH, FGF23
6hydroxyapatite448.9SPP1, MGP, FGF23
7phosphorus448.7SPP1, PTH, SLC34A1, FGF23
8arginine448.6FGF23, PTH, SPP1
91,25 dihydroxy vitamin d3448.6FGF23, SLC34A1, PTH, SPP1
10estrogen448.5PTH, MGP, SPP1
11calcitriol44 61 24 1110.8FGF23, SLC34A1, PTH, MGP, SPP1
12vitamin d447.8SPP1, MGP, PTH, SLC34A1, FGF23
13calcium44 50 24 1110.3SPP1, MGP, PTH, GALNT3, SLC34A1, FGF23

GO Terms for genes affiliated with Hyperphosphatemia

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Cellular components related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9FGF23, PTH, SPP1
2perinuclear region of cytoplasmGO:0484718.7SLC34A1, GALNT3, SPP1

Biological processes related to Hyperphosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:0550629.6FGF23, SLC34A1
2response to lead ionGO:0102889.3SLC34A1, PTH
3response to vitamin DGO:0332809.2SPP1, PTH
4ossificationGO:0015039.1SLC34A1, MGP
5response to cadmium ionGO:0466869.0SLC34A1, PTH

Products for genes affiliated with Hyperphosphatemia

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  • Antibodies
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Sources for Hyperphosphatemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet