MCID: HYP466
MIFTS: 28

Hyperplastic Polyposis Syndrome malady

Categories: Gastrointestinal diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Hyperplastic Polyposis Syndrome

About this section
Sources:
51Orphanet, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Hyperplastic Polyposis Syndrome:

Name: Hyperplastic Polyposis Syndrome 51
 
Serrated Polyposis 51

Classifications:



External Ids:

Orphanet51 157798
ICD10 via Orphanet28 D12.6

Summaries for Hyperplastic Polyposis Syndrome

About this section
MalaCards based summary: Hyperplastic Polyposis Syndrome, also known as serrated polyposis, is related to hypothyroidism and capillariasis. An important gene associated with Hyperplastic Polyposis Syndrome is MUTYH (MutY DNA Glycosylase), and among its related pathways are Thyroid hormone signaling pathway and Hepatitis C. Affiliated tissues include colon, bone and lung, and related mouse phenotype tumorigenesis.

Related Diseases for Hyperplastic Polyposis Syndrome

About this section

Diseases related to Hyperplastic Polyposis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism10.2
2capillariasis10.1
3diarrhea10.1
4endotheliitis10.1
5myh9-related disorders10.1KRAS, MUTYH
6prostate cancer10.1
7renal cell carcinoma10.1
8canavan disease10.1
9thalassemia10.1
10chronic pyelonephritis10.1
11pyelonephritis10.1
12pedophilia10.1
13ehlers-danlos syndrome10.1
14prostatitis10.1
15impotence10.1
16leiomyosarcoma10.1
17cystadenocarcinoma10.1
18mucinous cystadenocarcinoma10.1
19pancreatitis10.1
20influenza10.1
21lymphosarcoma10.1
22erythema elevatum diutinum10.1
23gastric cancer, somatic10.1KRAS, MUTYH
24biliary tract neoplasm10.1KRAS, MUTYH
25ulnar neuropathy10.1KRAS, MUTYH
26organ system benign neoplasm10.0KRAS, MUTYH
27common variable immunodeficiency10.0KRAS, MUTYH
28restless legs syndrome10.0KRAS, MUTYH
29tenosynovitis of foot and ankle9.9KRAS, MUTYH
30eccrine papillary adenoma9.9BRAF, KRAS
31ovarian germ cell teratoma9.9BRAF, KRAS
32in situ pulmonary adenocarcinoma9.9BRAF, KRAS
33punctate acrokeratoderma freckle like pigmentation9.9BRAF, KRAS
34gingival recession9.9KRAS, MUTYH
35noonan syndrome 79.8BRAF, KRAS
36pyometritis9.8BRAF, KRAS
37familial abdominal aortic aneurysm9.8BRAF, KRAS
38pleomorphic xanthoastrocytoma9.7BRAF, KRAS
39hereditary congenital ptosis9.6BRAF, KRAS, MUTYH
40placental insufficiency9.6BRAF, KRAS, MUTYH
41non-invasive bladder urothelial carcinoma9.6BRAF, KRAS, MUTYH
42muscular dystrophy-dystroglycanopathy , type a, 29.5BRAF, KRAS, MUTYH
43leopard syndrome 19.5BRAF, KRAS
44cataract-intellectual disability-hypogonadism syndrome9.2BRAF, KRAS, MBD4, MUTYH
45colorectal cancer8.9BRAF, KRAS, MBD4, MUTYH

Graphical network of the top 20 diseases related to Hyperplastic Polyposis Syndrome:



Diseases related to hyperplastic polyposis syndrome

Symptoms for Hyperplastic Polyposis Syndrome

About this section

Drugs & Therapeutics for Hyperplastic Polyposis Syndrome

About this section

Drugs for Hyperplastic Polyposis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ursodeoxycholic acidapproved, investigationalPhase 2, Phase 378128-13-231401
Synonyms:
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oate
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid
(3a,5b,7b)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid
(3α,5β,7β)-3,7-dihydroxycholan-24-oic acid
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
128-13-2
17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol
3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid
3,7-Dihydroxycholan-24-oic acid
3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid
3-alpha,7-beta-Dihydroxycholanic acid
3-alpha,7-beta-Dioxycholanic acid
3a,7b-Dihydroxy-5b-cholan-24-oate
3a,7b-Dihydroxy-5b-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholanic acid
4-10-00-01604 (Beilstein Handbook Reference)
50809-41-1
5beta-Cholan-24-oic acid-3alpha,7beta-diol
5beta-Cholanic Acid-3alpha,7beta-diol
7-beta-Hydroxylithocholic acid
7beta-Hydroxylithocholic acid
80225-86-1
AB00513977
AC-18919
AC-2081
AC1L1LJH
Acide ursodesoxycholique
Acide ursodesoxycholique [INN-French]
Acido ursodeossicolico
Acido ursodeossicolico [Italian]
Acido ursodeoxicolico
Acido ursodeoxicolico [INN-Spanish]
Acidum ursodeoxycholicum
Acidum ursodeoxycholicum [INN-Latin]
Actigall
Actigall (TN)
Antigall
Arsacol
BB_NC-2372
BPBio1_001052
BRN 3219888
BSPBio_000956
C07880
C24H40O4
CCRIS 5502
CHEBI:9907
CHEMBL1551
CHEMBL73390
CID11516715
CID31401
CPD-10534
CPD000058403
Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)- (9CI)
Cholit-ursan
D00734
DB01586
Delursan
Deoxyursocholic Acid
Destolit
Deursil
Dom-ursodiol c
EINECS 204-879-3
HMS1570P18
ISO-URSODEOXYCHOLIC ACID
 
IU5
LMST04010033
LS-53033
Litursol
Lyeton
MLS000028461
MLS001066373
MolPort-001-794-630
MolPort-005-932-884
NCGC00179363-01
NCI60_028904
NSC 657950
NSC 683769
PHL-ursodiol c
PMS-ursodiol c
Peptarom
Prestwick0_000958
Prestwick1_000958
Prestwick2_000958
Prestwick3_000958
S1643_Selleck
SAM002264653
SMP2_000012
SMR000058403
SPBio_003105
Sodium Ursodeoxycholate
Solutrat
U-9000
U0030
U5127_SIGMA
UDCA
UDCS
UNII-724L30Y2QR
URSODEOXYCHOLIC ACID
UrSO
Urosdesoxycholate
Urosdesoxycholic acid
Urosiol
Ursacholic Acid
Ursacol
Urso
Urso (TN)
Urso 250
Urso DS
Urso Forte
Ursobilin
Ursochol
Ursodamor
Ursodeoxy cholic acid
Ursodeoxycholate
Ursodeoxycholic acid
Ursodeoxycholic acid (JP15/INN)
Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol
Ursodeoxycholicacid
Ursodesoxycholic acid
Ursodexycholate
Ursodexycholic Acid
Ursodexycholic acid
Ursodiol
Ursodiol (USP)
Ursodiol Tablets, 250 mg
Ursodiol Tablets, 500 mg
Ursodiol [USAN]
Ursofalk
Ursolvan
Ursosan
chenodeoxycholic acid
ursodeoxycholate
ursodiol
2Gastrointestinal AgentsPhase 2, Phase 36401

Interventional clinical trials:

idNameStatusNCT IDPhase
1Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) PatientsActive, not recruitingNCT00134758Phase 2, Phase 3
2Narrow Band Imaging in the Prediction of Surveillance Intervals After Polypectomy in Community Practice: Ready for (a European) Prime TimeCompletedNCT02196402

Search NIH Clinical Center for Hyperplastic Polyposis Syndrome

Genetic Tests for Hyperplastic Polyposis Syndrome

About this section

Anatomical Context for Hyperplastic Polyposis Syndrome

About this section

MalaCards organs/tissues related to Hyperplastic Polyposis Syndrome:

33
Colon, Bone, Lung, Myeloid

Animal Models for Hyperplastic Polyposis Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Hyperplastic Polyposis Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3BRAF, KRAS, MBD4, MUTYH

Publications for Hyperplastic Polyposis Syndrome

About this section

Articles related to Hyperplastic Polyposis Syndrome:

(show all 21)
idTitleAuthorsYear
1
Sarcomatous degeneration in fibrous dysplasia of the rib cage. (24088499)
2013
2
A consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis. (23784124)
2013
3
Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small cell lung cancer patients with an EGFR wild type genotype. (22770374)
2012
4
Hyponatremia in patients treated with terlipressin for severe gastrointestinal bleeding due to portal hypertension. (20931555)
2010
5
Expression of B7-H1 on peripheral myeloid dendritic cells in patients with HIV infection and its correlation with diseases progression]. (20450779)
2010
6
Extraocular muscle hypertrophy in myotonia congenita: Mutation identified in the SCN4A gene (V445M). (19840739)
2009
7
Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3. (19564639)
2009
8
CRP/CD11b ratio: a novel parameter for detecting gram-positive sepsis. (19480860)
2009
9
Impotence and libido in Arabic medical literature. (18792558)
2008
10
Is mumps making a comeback? (18923686)
2007
11
Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis. (16427347)
2006
12
Interleukin-6 gene polymorphism in renal transplant patients with and without gingival overgrowth. (16104959)
2005
13
A gel-free SNP genotyping method: bioluminometric assay coupled with modified primer extension reactions (BAMPER) directly from double-stranded PCR products. (15241797)
2004
14
A high frequency of BRCA2 gene mutations in Polish families with ovarian and stomach cancer. (14647210)
2003
15
Congenital ganglioglioma. (12003306)
2002
16
Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen. (11986329)
2002
17
Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant. (11900546)
2002
18
HIV type 1 infection of human macrophages induces an upregulation of manganese superoxide dismutase gene that may protect cells from death. (9546802)
1998
19
Dopamine D4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects. (9088883)
1997
20
Hemorrhagic shock and encephalopathy syndrome. (1746741)
1991
21
Sacroiliitis in women--a late sequela to acute salpingitis. (7468666)
1980

Variations for Hyperplastic Polyposis Syndrome

About this section

Expression for genes affiliated with Hyperplastic Polyposis Syndrome

About this section
Search GEO for disease gene expression data for Hyperplastic Polyposis Syndrome.

Pathways for genes affiliated with Hyperplastic Polyposis Syndrome

About this section

GO Terms for genes affiliated with Hyperplastic Polyposis Syndrome

About this section

Biological processes related to Hyperplastic Polyposis Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:00435249.1BRAF, KRAS

Molecular functions related to Hyperplastic Polyposis Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA N-glycosylase activityGO:00191049.3MBD4, MUTYH

Sources for Hyperplastic Polyposis Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet