MCID: HYP020
MIFTS: 58

Hyperprolactinemia malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases categories

Aliases & Classifications for Hyperprolactinemia

About this section

Hyperprolactinemia, Aliases & Descriptions:

Name: Hyperprolactinemia 45 9 11 43 60
Chiari-Frommel Syndrome 9 41 60
 
Pregnancy-Related a-G Syndrome 9
Hyperprolactinaemia 9


Classifications:



External Ids:

OMIM45 615555
Disease Ontology9 DOID:12700
ICD1025 E22.1

Summaries for Hyperprolactinemia

About this section


OMIM:45 Hyperprolactinemia unrelated to pregnancy occurs in approximately 0.1 to 0.3% of the general population and may result... (615555) more...

MalaCards based summary: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to infertility and schizophrenia, and has symptoms including menorrhagia, infertility and oligomenorrhea. An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are ErbB4 signaling events and Nuclear signaling by ERBB4. The drugs bromocriptine and cabergoline and the compounds nemonapride and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and breast, and related mouse phenotypes are adipose tissue and reproductive system.

Disease Ontology:9 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

Related Diseases for Hyperprolactinemia

About this section

Diseases in the Hyperprolactinemia family:

Familial Hyperprolactinemia

Diseases related to Hyperprolactinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.8CGB, PRLR, PRL
2schizophrenia30.5DRD4, PRL, DBH
3prolactinoma30.4CGB, GAL, PRL, PTHLH
4pituitary adenoma30.4GAL, PRLR, PRL
5adenoma30.3PRL, PRLR, GAL, CGB
6breast cancer30.3CGB, PRLR, PTHLH
7acromegaly30.2PRL, PRLR, GAL, CGB
8pituitary tumors30.2GAL, PRL
9psychotic disorder29.9DRD4, PRL, DBH
10hypoglycemia29.8GAL, PRL, DBH
11migraine29.8DBH, DRD4
12bipolar disorder29.6DRD4, DBH
13major depressive disorder and accelerated response to antidepressant drug treatment10.4DRD4
14oppositional defiant disorder10.4DRD4
15pathological gambling10.4DRD4
16systemic lupus erythematosus10.4
17hypothyroidism10.4
18lupus erythematosus10.4
19thyroiditis10.3
20familial hyperprolactinemia10.3
21amenorrhea10.3
22prostatitis10.3
23klinefelter's syndrome10.2PRL, CGB
24obesity10.2
25neuronitis10.2
26gigantism10.2
27ahumada del castillo syndrome10.2
28polycystic ovary syndrome10.2
29acth deficiency10.2
30hyperandrogenism10.1
31gynecomastia10.1
32empty sella syndrome10.1
33anovulation10.1
34cervicitis10.1
35ovarian disease10.1
36galactorrhoea-hyperprolactinaemia10.1
37growth hormone deficiency10.1
38aneurysm10.1
39parkinson disease, late-onset10.1DBH
40insulinoma10.1GAL, PRLR
41prostate cancer10.0
42insulin-like growth factor i10.0
43arthritis10.0
44diabetes insipidus10.0
45hypogonadotropism10.0
46germinoma10.0
47fibrous dysplasia10.0
48autism spectrum disorder10.0
49cholestasis10.0
50hyperaldosteronism10.0

Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Symptoms for Hyperprolactinemia

About this section

Symptoms by clinical synopsis from OMIM:

615555

Clinical features from OMIM:

615555

HPO human phenotypes related to Hyperprolactinemia:

id Description Frequency HPO Source Accession
1 menorrhagia rare (5%) HP:0000132
2 infertility rare (5%) HP:0000789
3 oligomenorrhea rare (5%) HP:0000876
4 galactorrhea rare (5%) HP:0100829
5 autosomal dominant inheritance HP:0000006

Drugs & Therapeutics for Hyperprolactinemia

About this section

Drug clinical trials:

Search ClinicalTrials for Hyperprolactinemia

Search NIH Clinical Center for Hyperprolactinemia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hyperprolactinemia

About this section

Anatomical Context for Hyperprolactinemia

About this section

MalaCards organs/tissues related to Hyperprolactinemia:

31
Pituitary, Bone, Breast, Thyroid, Testes, Ovary, Prostate, Kidney, Brain, Heart, Whole blood, Cortex, Colon, Liver, Uterus, Testis, Cervix, Hypothalamus, Pineal

Animal Models for Hyperprolactinemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Hyperprolactinemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PRLR, DBH, PTHLH
2MP:00053898.2GAL, PRLR, PRL, PTHLH
3MP:00053918.1PTHLH, DBH, PRLR, DRD4
4MP:00053797.8PTHLH, DBH, PRL, PRLR, GAL
5MP:00107717.8PTHLH, DBH, PRL, PRLR, GAL
6MP:00053867.4GAL, DRD4, PRLR, PRL, DBH, PTHLH
7MP:00036317.4PTHLH, DBH, PRL, PRLR, DRD4, GAL
8MP:00053767.2PTHLH, DBH, PRL, PRLR, DRD4, GAL

Publications for Hyperprolactinemia

About this section

Articles related to Hyperprolactinemia:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
The short-term effects of risperidone-induced hyperprolactinemia on lipid metabolism in drug-naA^ve children and adolescents. (25670946)
2015
2
Role of Ki-67 in acromegalic patients with hyperprolactinemia: Retrospective analysis in 61 Chinese Patients. (25796164)
2015
3
Effect of the addition of aripiprazole on hyperprolactinemia associated with risperidone long-acting injection. (23775053)
2013
4
In vitro examination of effects of hyperprolactinemia and hypoprolactinemia on seminal vesicle contractions. (23352373)
2013
5
Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis. (23590895)
2013
6
Hyperprolactinemia in children: clinical features and long-term results. (23329759)
2012
7
Unfavorable effects of hyperprolactinemia in autoimmune endocrine disorders. (22635088)
2012
8
A case of sibutramine-induced hyperprolactinemia. (22167128)
2011
9
Frequency of anticardiolipin Ac in patients with hyperprolactinemia. (22029040)
2011
10
Treatment with aripiprazole for hyperprolactinemia induced by pituitary microadenoma in a bipolar I disorder patient. (20075655)
2010
11
Hyperprolactinemia following chronic alcohol administration. (20616493)
2010
12
Hyperprolactinemia and prolactinomas. (18226731)
2008
13
A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. (18480682)
2008
14
Hyperprolactinemia. (18404389)
2008
15
Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. (18095129)
2007
16
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia. (17187006)
2006
17
Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. (16705551)
2006
18
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
19
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
20
A case of Costello with parathyroid adenoma and hyperprolactinemia. (14699620)
2004
21
Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8+ cells in vivo. (15067204)
2004
22
Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report. (15367061)
2004
23
Risperidone-induced hyperprolactinemia in an elderly woman. (12450970)
2002
24
Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. (12522680)
2002
25
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
26
Changes in substance P content at the hypothalamic-pituitary axis during the Wallerian degeneration of peripheral sympathetic neurons after superior cervical ganglionectomy in male rats: effect of hyperprolactinemia. (11395934)
2001
27
Lack of association between hyperprolactinemia and colon carcinoma. (10705875)
2000
28
Paradoxical stimulation of prolactin secretion by L-dopa in metastatic prostate cancer and its possible role in prostate-cancer-related hyperprolactinemia. (10765095)
2000
29
Neuroleptic-induced hyperprolactinemia. (10190228)
1999
30
Dopaminergic modulation of hexarelin-induced GH and PRL secretion in hyperprolactinemia. (9586422)
1998
31
High association between hyperprolactinemia and anticardiolipin antibodies. (9228159)
1997
32
Hyperprolactinemia. Causes, consequences, and treatment options. (8650091)
1996
33
Two cases of alprazolam-induced hyperprolactinemia in patients with panic disorder. (8803653)
1996
34
Induction of proenkephalin in tuberoinfundibular dopaminergic neurons by hyperprolactinemia: the role of sex steroids. (7750466)
1995
35
Plasma levels of parathyroid hormone-related peptide are elevated in hyperprolactinemia and correlated to bone density status. (7639111)
1995
36
Hyperprolactinemia in oligospermic Nigerian males: effect of bromocriptine treatment. (8012447)
1994
37
Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)
1994
38
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
39
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
40
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
41
Paradoxical prolactin response to growth hormone-releasing hormone in a patient with hyperprolactinemia and empty sella. (1752237)
1991
42
The effects of pregnancy on prolactin secretion in occulted hyperprolactinemia]. (1744458)
1991
43
Hyperprolactinemia and risk for relapse of cocaine abuse. (2257288)
1990
44
The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia]. (2114023)
1990
45
Effects of gonadotropin-releasing hormone agonist and clomiphene citrate on estrogen/progesterone-induced hyperprolactinemia in monkeys. (2105248)
1990
46
Isolated ACTH deficiency associated with transient thyrotoxicosis and hyperprolactinemia. (2555145)
1989
47
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
48
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
49
Septo-optic dysplasia and median cleft face syndrome in a patient with isolated growth hormone deficiency and hyperprolactinemia. (6846278)
1983
50
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983

Variations for Hyperprolactinemia

About this section

UniProtKB/Swiss-Prot genetic disease variations for Hyperprolactinemia:

62
id Symbol AA change Variation ID SNP ID
1PRLRp.His212ArgVAR_070895

Expression for genes affiliated with Hyperprolactinemia

About this section
Search GEO for disease gene expression data for Hyperprolactinemia.

Pathways for genes affiliated with Hyperprolactinemia

About this section

Compounds for genes affiliated with Hyperprolactinemia

About this section

Compounds related to Hyperprolactinemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1nemonapride43 49 2811.9DRD4, PRL
2remoxipride43 1210.9PRL, DRD4
3fluphenazine28 43 49 1212.8PRL, DRD4
4terguride43 2810.8PRL, DRD4
5sulpiride43 28 1211.7PRL, DRD4
6hexarelin43 2810.7PRL, GAL
7pyridostigmine43 1210.7PRL, GAL
8carbidopa43 2810.6DBH, PRL
9progestin439.6PTHLH, PRL, PRLR
10lisuride43 28 1211.5DRD4, PRL
11mirtazapine43 49 1211.4GAL, PRL
12thyroxine43 2410.4CGB, PRL, PTHLH
13octreotide43 59 28 1212.3GAL, PRL, PTHLH
14melatonin43 28 59 24 1213.3PRL, DRD4, GAL
15pergolide43 28 1211.2DRD4, PRL
16maoa439.2DRD4, DBH
17mhpg439.2DRD4, PRL, DBH
18progesterone43 28 59 24 1213.0CGB, PRL, PTHLH, PRLR
19metoclopramide43 49 1211.0GAL, PRL, DBH
20clonidine43 49 28 1212.0DBH, GAL, PRL
21opiate439.0PRL, GAL, DBH
22bromocriptine43 28 1211.0GAL, DRD4, PRL, PRLR
23corticosterone43 59 2411.0GAL, DBH, PRL
24lead439.0PTHLH, DBH, DRD4
25nicotine43 28 49 1211.9PTHLH, DBH, DRD4
26catecholamine438.9DRD4, DBH, GAL
27acth438.8DBH, GAL, PRL
28levodopa43 129.5PRL, DRD4, GAL, DBH
29cocaine43 129.5DRD4, DBH, PRL, GAL
30estradiol43 24 1210.5PRLR, PRL, GAL, PTHLH, CGB
315-hydroxytryptamine438.5PRL, DRD4, GAL, DBH
32hydrogen43 249.5PRLR, GAL, PTHLH, DBH
33epinephrine43 24 1210.5GAL, PRL, DBH, DRD4
34testosterone43 59 24 1211.5PRL, CGB, PTHLH, PRLR, GAL
35estrogen438.5CGB, PTHLH, PRL, PRLR, GAL
36gaba438.4DRD4, GAL, DBH
37sodium43 249.4DBH, DRD4, GAL, PTHLH
38adenylate438.3PTHLH, GAL, DRD4, DBH
39phosphatidylinositol438.3PTHLH, GAL, PRLR, DBH
40nitric oxide43 24 1210.3PRLR, PTHLH, DBH, GAL
41gnrh438.2DBH, PRL, GAL, PRLR, CGB
42glutamate438.2PRLR, DBH, DRD4, GAL
43dopamine43 28 24 1211.2DRD4, PRL, DBH, PRLR, GAL
44dexamethasone43 49 28 1211.1PRLR, PRL, DBH, PTHLH, GAL
45alanine438.1CGB, GAL, DBH, PRLR, PTHLH
46glucose438.0PRL, GAL, DBH, PTHLH, CGB
47norepinephrine43 24 1210.0PRL, DBH, PTHLH, DRD4, GAL
48cyclic amp43 249.0CGB, GAL, DBH, PTHLH, DRD4
49serine437.9DRD4, PTHLH, DBH, PRLR, GAL
50tyrosine437.9PRLR, DBH, PTHLH, DRD4, GAL

GO Terms for genes affiliated with Hyperprolactinemia

About this section

Cellular components related to Hyperprolactinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.3CGB, GAL, PRLR, PRL, DBH, PTHLH

Biological processes related to Hyperprolactinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.7PRLR, PRL
2female pregnancyGO:00075659.5PRL, PTHLH
3lactationGO:00075959.4PRLR, PRL
4fear responseGO:00425969.2DRD4, DBH
5behavioral response to ethanolGO:00481499.2DRD4, DBH
6response to amphetamineGO:00019759.0DBH, DRD4

Molecular functions related to Hyperprolactinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.1CGB, PRL, PTHLH

Products for genes affiliated with Hyperprolactinemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hyperprolactinemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet