MCID: HYP020
MIFTS: 67

Hyperprolactinemia malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases, Metabolic diseases categories
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Summaries for Hyperprolactinemia

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Disease Ontology:8 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

MalaCards based summary: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to infertility and schizophrenia, and has symptoms including An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are ErbB4 signaling events and Nuclear signaling by ERBB4. The drugs bromocriptine and cabergoline and the compounds nemonapride and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and breast, and related mouse phenotypes are adipose tissue and reproductive system.

Wikipedia:65 Hyperprolactinaemia or hyperprolactinemia (HP) is the presence of abnormally high levels of prolactin in... more...

Description from OMIM:46 615555

Aliases & Classifications for Hyperprolactinemia

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 62UMLS, 42NIH Rare Diseases, 48Orphanet, 57SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Hyperprolactinemia, Aliases & Descriptions:

Name: Hyperprolactinemia 8 46 10 44 62
Chiari-Frommel Syndrome 8 42 62
Hyperprolactinaemia 8 62
 
Familial Isolated Prolactin Receptor Deficiency 48
Pregnancy-Related a-G Syndrome 8
Familial Hyperprolactinemia 48


Classifications:



External Ids:

Disease Ontology8 DOID:12700
OMIM46 615555
ICD10 via Orphanet26 E22.1
ICD1025 E22.1

Related Diseases for Hyperprolactinemia

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Diseases related to Hyperprolactinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.8CGB, PRLR, PRL
2schizophrenia30.5DRD4, PRL, DBH
3prolactinoma30.4CGB, GAL, PRL, PTHLH
4pituitary adenoma30.4GAL, PRLR, PRL
5adenoma30.3PRL, PRLR, GAL, CGB
6breast cancer30.3CGB, PRLR, PTHLH
7acromegaly30.2PRL, PRLR, GAL, CGB
8pituitary tumors30.2GAL, PRL
9psychotic disorder29.9DRD4, PRL, DBH
10hypoglycemia29.8GAL, PRL, DBH
11migraine29.8DBH, DRD4
12bipolar disorder29.6DRD4, DBH
13seasonal affective disorder10.4DRD4
14oppositional defiant disorder10.4DRD4
15systemic lupus erythematosus10.4
16hypothyroidism10.4
17lupus erythematosus10.4
18pathological gambling10.4DRD4
19thyroiditis10.3
20prostatitis10.3
21amenorrhea10.3
22klinefelter's syndrome10.2PRL, CGB
23ahumada del castillo syndrome10.2
24obesity10.2
25neuronitis10.2
26gigantism10.2
27schizoaffective disorder10.2DRD4, PRL
28polycystic ovary syndrome10.2
29empty sella syndrome10.2
30acth deficiency10.2
31hypertension10.1
32multiple sclerosis10.1
33mccune albright syndrome10.1
34hyperandrogenism10.1
35gynecomastia10.1
36anovulation10.1
37cervicitis10.1
38endometriosis10.1
39ovarian disease10.1
40growth hormone deficiency10.1
41isolated acth deficiency10.1
42aneurysm10.1
43thromboembolism10.1
44parkinson's disease10.1DBH
45insulinoma10.1GAL, PRLR
46conduct disorder10.0DRD4, DBH
47gilles de la tourette syndrome10.0DRD4, DBH
48hyperthyroidism10.0CGB, GAL, PRL
49arthritis10.0
50hodgkin's lymphoma10.0

Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Symptoms for Hyperprolactinemia

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Symptoms by clinical synopsis from OMIM:

615555

Clinical features from OMIM:

615555

HPO human phenotypes related to Hyperprolactinemia:

id Description Frequency HPO Source Accession
1 menorrhagia rare (5%) HP:0000132
2 infertility rare (5%) HP:0000789
3 oligomenorrhea rare (5%) HP:0000876
4 galactorrhea rare (5%) HP:0100829
5 autosomal dominant inheritance HP:0000006

Drugs & Therapeutics for Hyperprolactinemia

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Drug clinical trials:

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Search NIH Clinical Center for Hyperprolactinemia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Hyperprolactinemia

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Anatomical Context for Hyperprolactinemia

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MalaCards organs/tissues related to Hyperprolactinemia:

32
Pituitary, Bone, Breast, Testes, Thyroid, Prostate, Ovary, Kidney, Brain, Heart, Whole blood, Cortex, Colon, Liver, Uterus, Testis, Cervix, Hypothalamus, Pineal

Animal Models for Hyperprolactinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperprolactinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PRLR, DBH, PTHLH
2MP:00053898.2GAL, PRLR, PRL, PTHLH
3MP:00053918.1PTHLH, DBH, PRLR, DRD4
4MP:00053797.8PTHLH, DBH, PRL, PRLR, GAL
5MP:00107717.8PTHLH, DBH, PRL, PRLR, GAL
6MP:00053867.4GAL, DRD4, PRLR, PRL, DBH, PTHLH
7MP:00036317.4PTHLH, DBH, PRL, PRLR, DRD4, GAL
8MP:00053767.2PTHLH, DBH, PRL, PRLR, DRD4, GAL

Publications for Hyperprolactinemia

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Articles related to Hyperprolactinemia:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Effect of the addition of aripiprazole on hyperprolactinemia associated with risperidone long-acting injection. (23775053)
2013
2
In vitro examination of effects of hyperprolactinemia and hypoprolactinemia on seminal vesicle contractions. (23352373)
2013
3
Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis. (23590895)
2013
4
Hyperprolactinemia in children: clinical features and long-term results. (23329759)
2012
5
Unfavorable effects of hyperprolactinemia in autoimmune endocrine disorders. (22635088)
2012
6
A case of sibutramine-induced hyperprolactinemia. (22167128)
2011
7
Frequency of anticardiolipin Ac in patients with hyperprolactinemia. (22029040)
2011
8
Treatment with aripiprazole for hyperprolactinemia induced by pituitary microadenoma in a bipolar I disorder patient. (20075655)
2010
9
Hyperprolactinemia following chronic alcohol administration. (20616493)
2010
10
Hyperprolactinemia and prolactinomas. (18226731)
2008
11
A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. (18480682)
2008
12
Hyperprolactinemia. (18404389)
2008
13
Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. (18095129)
2007
14
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia. (17187006)
2006
15
Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. (16705551)
2006
16
Macroprolactinemia in a patient with infertility and hyperprolactinemia. (17195425)
2006
17
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
18
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
19
A case of Costello with parathyroid adenoma and hyperprolactinemia. (14699620)
2004
20
Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8+ cells in vivo. (15067204)
2004
21
Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report. (15367061)
2004
22
Risperidone-induced hyperprolactinemia in an elderly woman. (12450970)
2002
23
Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. (12522680)
2002
24
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
25
Detection of macroprolactinemia with the polyethylene glycol precipitation test in systemic lupus erythematosus patients with hyperprolactinemia. (11403264)
2001
26
Changes in substance P content at the hypothalamic-pituitary axis during the Wallerian degeneration of peripheral sympathetic neurons after superior cervical ganglionectomy in male rats: effect of hyperprolactinemia. (11395934)
2001
27
Lack of association between hyperprolactinemia and colon carcinoma. (10705875)
2000
28
Paradoxical stimulation of prolactin secretion by L-dopa in metastatic prostate cancer and its possible role in prostate-cancer-related hyperprolactinemia. (10765095)
2000
29
Neuroleptic-induced hyperprolactinemia. (10190228)
1999
30
Dopaminergic modulation of hexarelin-induced GH and PRL secretion in hyperprolactinemia. (9586422)
1998
31
High association between hyperprolactinemia and anticardiolipin antibodies. (9228159)
1997
32
Hyperprolactinemia. Causes, consequences, and treatment options. (8650091)
1996
33
Two cases of alprazolam-induced hyperprolactinemia in patients with panic disorder. (8803653)
1996
34
Induction of proenkephalin in tuberoinfundibular dopaminergic neurons by hyperprolactinemia: the role of sex steroids. (7750466)
1995
35
Plasma levels of parathyroid hormone-related peptide are elevated in hyperprolactinemia and correlated to bone density status. (7639111)
1995
36
Hyperprolactinemia in oligospermic Nigerian males: effect of bromocriptine treatment. (8012447)
1994
37
Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)
1994
38
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
39
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
40
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
41
Paradoxical prolactin response to growth hormone-releasing hormone in a patient with hyperprolactinemia and empty sella. (1752237)
1991
42
The effects of pregnancy on prolactin secretion in occulted hyperprolactinemia]. (1744458)
1991
43
Hyperprolactinemia and risk for relapse of cocaine abuse. (2257288)
1990
44
The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia]. (2114023)
1990
45
Effects of gonadotropin-releasing hormone agonist and clomiphene citrate on estrogen/progesterone-induced hyperprolactinemia in monkeys. (2105248)
1990
46
Isolated ACTH deficiency associated with transient thyrotoxicosis and hyperprolactinemia. (2555145)
1989
47
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
48
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
49
Septo-optic dysplasia and median cleft face syndrome in a patient with isolated growth hormone deficiency and hyperprolactinemia. (6846278)
1983
50
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983

Variations for Hyperprolactinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hyperprolactinemia:

64
id Symbol AA change Variation ID SNP ID
1PRLRp.His212ArgVAR_070895

Expression for genes affiliated with Hyperprolactinemia

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Expression patterns in normal tissues for genes affiliated with Hyperprolactinemia

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Pathways for genes affiliated with Hyperprolactinemia

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Compounds for genes affiliated with Hyperprolactinemia

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Compounds related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1nemonapride44 50 2811.9DRD4, PRL
2remoxipride44 1110.9PRL, DRD4
3terguride44 2810.8PRL, DRD4
4fluphenazine28 44 50 1112.8PRL, DRD4
5sulpiride44 28 1111.7PRL, DRD4
6hexarelin44 2810.7PRL, GAL
7pyridostigmine44 1110.7PRL, GAL
8carbidopa44 2810.6DBH, PRL
9progestin449.6PTHLH, PRL, PRLR
10lisuride44 28 1111.5DRD4, PRL
11paliperidone44 1110.5DRD4, PRL
12thyroxine44 2410.4CGB, PRL, PTHLH
13octreotide44 61 28 1112.3PTHLH, PRL, GAL
14melatonin44 28 61 24 1113.3PRL, DRD4, GAL
15maoa449.2DRD4, DBH
16mhpg449.2DRD4, PRL, DBH
17progesterone44 28 61 24 1113.0CGB, PRLR, PRL, PTHLH
18metoclopramide44 50 1111.0GAL, PRL, DBH
19clonidine44 50 28 1112.0GAL, PRL, DBH
20opiate449.0GAL, PRL, DBH
21bromocriptine44 28 1111.0PRL, PRLR, DRD4, GAL
22corticosterone44 61 2411.0DBH, PRL, GAL
23lead449.0PTHLH, DBH, DRD4
24homovanillic acid44 249.9PRL, DBH
25nicotine44 28 50 1111.9DRD4, DBH, PTHLH
26catecholamine448.9GAL, DRD4, DBH
27acth448.8GAL, PRL, DBH
28levodopa44 119.5GAL, DRD4, PRL, DBH
29cocaine44 119.5DBH, PRL, DRD4, GAL
30estradiol44 24 1110.5PTHLH, PRL, PRLR, GAL, CGB
315-hydroxytryptamine448.5GAL, DRD4, PRL, DBH
32hydrogen44 249.5GAL, PRLR, DBH, PTHLH
33epinephrine44 24 1110.5GAL, DRD4, PRL, DBH
34testosterone44 61 24 1111.5PTHLH, PRL, PRLR, GAL, CGB
35estrogen448.5PTHLH, PRL, PRLR, GAL, CGB
36gaba448.4DBH, DRD4, GAL
37sodium44 249.4GAL, DRD4, DBH, PTHLH
38adenylate448.3GAL, DRD4, DBH, PTHLH
39phosphatidylinositol448.3PTHLH, DBH, PRLR, GAL
40nitric oxide44 24 1110.3GAL, PRLR, DBH, PTHLH
41gnrh448.2CGB, GAL, PRLR, PRL, DBH
42glutamate448.2DBH, PRLR, DRD4, GAL
43dopamine44 28 24 1111.2DBH, PRL, PRLR, DRD4, GAL
44dexamethasone44 50 28 1111.1PTHLH, DBH, PRL, PRLR, GAL
45alanine448.1PTHLH, DBH, PRLR, GAL, CGB
46glucose448.0PTHLH, DBH, PRL, GAL, CGB
47norepinephrine44 24 1110.0PTHLH, DBH, PRL, DRD4, GAL
48cyclic amp44 249.0PTHLH, DBH, DRD4, GAL, CGB
49serine447.9PTHLH, DBH, PRLR, DRD4, GAL
50tyrosine447.9PTHLH, DBH, PRLR, DRD4, GAL

GO Terms for genes affiliated with Hyperprolactinemia

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Cellular components related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3CGB, GAL, PRLR, PRL, DBH, PTHLH

Biological processes related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7PRLR, PRL
2female pregnancyGO:0075659.5PRL, PTHLH
3lactationGO:0075959.4PRLR, PRL
4fear responseGO:0425969.2DRD4, DBH
5behavioral response to ethanolGO:0481499.2DRD4, DBH
6response to amphetamineGO:0019759.0DBH, DRD4

Molecular functions related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1CGB, PRL, PTHLH

Products for genes affiliated with Hyperprolactinemia

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Sources for Hyperprolactinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet