MCID: HYP020
MIFTS: 67

Hyperprolactinemia malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases, Metabolic diseases categories

Summaries for Hyperprolactinemia

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OMIM:46 Hyperprolactinemia unrelated to pregnancy occurs in approximately 0.1 to 0.3% of the general population and may result... (615555) more...

MalaCards based summary: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to infertility and schizophrenia, and has symptoms including menorrhagia, infertility and oligomenorrhea. An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are ErbB4 signaling events and Nuclear signaling by ERBB4. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds nemonapride and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and breast, and related mouse phenotypes are adipose tissue and reproductive system.

Disease Ontology:9 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

Wikipedia:64 Hyperprolactinaemia or hyperprolactinemia (HP) is the presence of abnormally high levels of prolactin in... more...

Aliases & Classifications for Hyperprolactinemia

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Sources:
9Disease Ontology, 46OMIM, 11DISEASES, 44Novoseek, 61UMLS, 42NIH Rare Diseases, 48Orphanet, 56SNOMED-CT, 34MeSH, 27ICD10 via Orphanet, 26ICD10
See all sources

Hyperprolactinemia, Aliases & Descriptions:

Name: Hyperprolactinemia 9 46 11 44 61
Chiari-Frommel Syndrome 9 42 61
Hyperprolactinaemia 9 61
 
Familial Isolated Prolactin Receptor Deficiency 48
Pregnancy-Related a-G Syndrome 9
Familial Hyperprolactinemia 48


Classifications:



External Ids:

Disease Ontology9 DOID:12700
OMIM46 615555
ICD10 via Orphanet27 E22.1
ICD1026 E22.1

Related Diseases for Hyperprolactinemia

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Diseases related to Hyperprolactinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.8CGB, PRLR, PRL
2schizophrenia30.5DRD4, PRL, DBH
3prolactinoma30.4CGB, GAL, PRL, PTHLH
4pituitary adenoma30.4GAL, PRLR, PRL
5adenoma30.4PRL, PRLR, GAL, CGB
6breast cancer30.3CGB, PRLR, PTHLH
7acromegaly30.2PRL, PRLR, GAL, CGB
8pituitary tumors30.2GAL, PRL
9psychotic disorder29.9DRD4, PRL, DBH
10hypoglycemia29.8GAL, PRL, DBH
11migraine29.8DBH, DRD4
12bipolar disorder29.6DRD4, DBH
13seasonal affective disorder10.4DRD4
14oppositional defiant disorder10.4DRD4
15systemic lupus erythematosus10.4
16hypothyroidism10.4
17lupus erythematosus10.4
18pathological gambling10.4DRD4
19thyroiditis10.3
20prostatitis10.3
21amenorrhea10.3
22klinefelter's syndrome10.2PRL, CGB
23ahumada del castillo syndrome10.2
24obesity10.2
25neuronitis10.2
26gigantism10.2
27schizoaffective disorder10.2DRD4, PRL
28polycystic ovary syndrome10.2
29empty sella syndrome10.2
30acth deficiency10.2
31hypertension10.1
32multiple sclerosis10.1
33mccune albright syndrome10.1
34hyperandrogenism10.1
35gynecomastia10.1
36anovulation10.1
37cervicitis10.1
38endometriosis10.1
39ovarian disease10.1
40growth hormone deficiency10.1
41isolated acth deficiency10.1
42aneurysm10.1
43thromboembolism10.1
44parkinson's disease10.1DBH
45insulinoma10.1GAL, PRLR
46conduct disorder10.0DRD4, DBH
47gilles de la tourette syndrome10.0DRD4, DBH
48hyperthyroidism10.0CGB, GAL, PRL
49arthritis10.0
50hodgkin's lymphoma10.0

Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Symptoms for Hyperprolactinemia

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Symptoms by clinical synopsis from OMIM:

615555

Clinical features from OMIM:

615555

HPO human phenotypes related to Hyperprolactinemia:

id Description Frequency HPO Source Accession
1 menorrhagia rare (5%) HP:0000132
2 infertility rare (5%) HP:0000789
3 oligomenorrhea rare (5%) HP:0000876
4 galactorrhea rare (5%) HP:0100829
5 autosomal dominant inheritance HP:0000006

Drugs & Therapeutics for Hyperprolactinemia

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Drug clinical trials:

Search ClinicalTrials for Hyperprolactinemia

Search NIH Clinical Center for Hyperprolactinemia

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Hyperprolactinemia

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Anatomical Context for Hyperprolactinemia

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MalaCards organs/tissues related to Hyperprolactinemia:

32
Pituitary, Bone, Breast, Testes, Thyroid, Prostate, Ovary, Kidney, Brain, Heart, Whole blood, Cortex, Colon, Liver, Uterus, Testis, Cervix, Hypothalamus, Pineal

Animal Models for Hyperprolactinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperprolactinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PRLR, DBH, PTHLH
2MP:00053898.2GAL, PRLR, PRL, PTHLH
3MP:00053918.1PTHLH, DBH, PRLR, DRD4
4MP:00053797.8PTHLH, DBH, PRL, PRLR, GAL
5MP:00107717.8PTHLH, DBH, PRL, PRLR, GAL
6MP:00053867.4GAL, DRD4, PRLR, PRL, DBH, PTHLH
7MP:00036317.4PTHLH, DBH, PRL, PRLR, DRD4, GAL
8MP:00053767.2PTHLH, DBH, PRL, PRLR, DRD4, GAL

Publications for Hyperprolactinemia

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Articles related to Hyperprolactinemia:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Effect of the addition of aripiprazole on hyperprolactinemia associated with risperidone long-acting injection. (23775053)
2013
2
In vitro examination of effects of hyperprolactinemia and hypoprolactinemia on seminal vesicle contractions. (23352373)
2013
3
Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis. (23590895)
2013
4
Hyperprolactinemia in children: clinical features and long-term results. (23329759)
2012
5
Unfavorable effects of hyperprolactinemia in autoimmune endocrine disorders. (22635088)
2012
6
A case of sibutramine-induced hyperprolactinemia. (22167128)
2011
7
Frequency of anticardiolipin Ac in patients with hyperprolactinemia. (22029040)
2011
8
Treatment with aripiprazole for hyperprolactinemia induced by pituitary microadenoma in a bipolar I disorder patient. (20075655)
2010
9
Hyperprolactinemia following chronic alcohol administration. (20616493)
2010
10
Hyperprolactinemia and prolactinomas. (18226731)
2008
11
A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. (18480682)
2008
12
Hyperprolactinemia. (18404389)
2008
13
Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. (18095129)
2007
14
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia. (17187006)
2006
15
Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. (16705551)
2006
16
Macroprolactinemia in a patient with infertility and hyperprolactinemia. (17195425)
2006
17
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
18
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
19
A case of Costello with parathyroid adenoma and hyperprolactinemia. (14699620)
2004
20
Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8+ cells in vivo. (15067204)
2004
21
Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report. (15367061)
2004
22
Risperidone-induced hyperprolactinemia in an elderly woman. (12450970)
2002
23
Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. (12522680)
2002
24
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
25
Detection of macroprolactinemia with the polyethylene glycol precipitation test in systemic lupus erythematosus patients with hyperprolactinemia. (11403264)
2001
26
Changes in substance P content at the hypothalamic-pituitary axis during the Wallerian degeneration of peripheral sympathetic neurons after superior cervical ganglionectomy in male rats: effect of hyperprolactinemia. (11395934)
2001
27
Lack of association between hyperprolactinemia and colon carcinoma. (10705875)
2000
28
Paradoxical stimulation of prolactin secretion by L-dopa in metastatic prostate cancer and its possible role in prostate-cancer-related hyperprolactinemia. (10765095)
2000
29
Neuroleptic-induced hyperprolactinemia. (10190228)
1999
30
Dopaminergic modulation of hexarelin-induced GH and PRL secretion in hyperprolactinemia. (9586422)
1998
31
High association between hyperprolactinemia and anticardiolipin antibodies. (9228159)
1997
32
Hyperprolactinemia. Causes, consequences, and treatment options. (8650091)
1996
33
Two cases of alprazolam-induced hyperprolactinemia in patients with panic disorder. (8803653)
1996
34
Induction of proenkephalin in tuberoinfundibular dopaminergic neurons by hyperprolactinemia: the role of sex steroids. (7750466)
1995
35
Plasma levels of parathyroid hormone-related peptide are elevated in hyperprolactinemia and correlated to bone density status. (7639111)
1995
36
Hyperprolactinemia in oligospermic Nigerian males: effect of bromocriptine treatment. (8012447)
1994
37
Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)
1994
38
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
39
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
40
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
41
Paradoxical prolactin response to growth hormone-releasing hormone in a patient with hyperprolactinemia and empty sella. (1752237)
1991
42
The effects of pregnancy on prolactin secretion in occulted hyperprolactinemia]. (1744458)
1991
43
Hyperprolactinemia and risk for relapse of cocaine abuse. (2257288)
1990
44
The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia]. (2114023)
1990
45
Effects of gonadotropin-releasing hormone agonist and clomiphene citrate on estrogen/progesterone-induced hyperprolactinemia in monkeys. (2105248)
1990
46
Isolated ACTH deficiency associated with transient thyrotoxicosis and hyperprolactinemia. (2555145)
1989
47
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
48
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
49
Septo-optic dysplasia and median cleft face syndrome in a patient with isolated growth hormone deficiency and hyperprolactinemia. (6846278)
1983
50
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983

Variations for Hyperprolactinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hyperprolactinemia:

63
id Symbol AA change Variation ID SNP ID
1PRLRp.His212ArgVAR_070895

Expression for genes affiliated with Hyperprolactinemia

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Expression patterns in normal tissues for genes affiliated with Hyperprolactinemia

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Pathways for genes affiliated with Hyperprolactinemia

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Compounds for genes affiliated with Hyperprolactinemia

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Compounds related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1nemonapride44 50 2911.9DRD4, PRL
2remoxipride44 1210.9PRL, DRD4
3fluphenazine29 44 50 1212.8PRL, DRD4
4terguride44 2910.8DRD4, PRL
5sulpiride44 29 1211.7PRL, DRD4
6hexarelin44 2910.7PRL, GAL
7pyridostigmine44 1210.7PRL, GAL
8carbidopa44 2910.6DBH, PRL
9progestin449.6PTHLH, PRL, PRLR
10lisuride44 29 1211.5DRD4, PRL
11thyroxine44 2510.4CGB, PRL, PTHLH
12octreotide44 60 29 1212.3GAL, PRL, PTHLH
13melatonin44 29 60 25 1213.3PRL, DRD4, GAL
14paliperidone44 1210.2DRD4, PRL
15maoa449.2DRD4, DBH
16homovanillic acid44 2510.2PRL, DBH
17mhpg449.2DRD4, PRL, DBH
18progesterone44 29 60 25 1213.0CGB, PRL, PTHLH, PRLR
19metoclopramide44 50 1211.0GAL, PRL, DBH
20clonidine44 50 29 1212.0DBH, GAL, PRL
21opiate449.0PRL, GAL, DBH
22bromocriptine44 29 1211.0GAL, DRD4, PRL, PRLR
23corticosterone44 60 2511.0GAL, DBH, PRL
24lead449.0PTHLH, DBH, DRD4
25nicotine44 29 50 1211.9PTHLH, DBH, DRD4
26catecholamine448.9DRD4, DBH, GAL
27acth448.8DBH, GAL, PRL
28levodopa44 129.5PRL, DRD4, GAL, DBH
29cocaine44 129.5DRD4, DBH, PRL, GAL
30estradiol44 25 1210.5PRLR, PRL, GAL, PTHLH, CGB
315-hydroxytryptamine448.5PRL, DRD4, GAL, DBH
32hydrogen44 259.5PRLR, GAL, PTHLH, DBH
33epinephrine44 25 1210.5GAL, PRL, DBH, DRD4
34testosterone44 60 25 1211.5PRL, CGB, PTHLH, PRLR, GAL
35estrogen448.5CGB, PTHLH, PRL, PRLR, GAL
36gaba448.4DBH, DRD4, GAL
37sodium44 259.4DBH, DRD4, GAL, PTHLH
38adenylate448.3PTHLH, GAL, DRD4, DBH
39phosphatidylinositol448.3PTHLH, GAL, PRLR, DBH
40nitric oxide44 25 1210.3PRLR, PTHLH, DBH, GAL
41gnrh448.2DBH, PRL, GAL, PRLR, CGB
42glutamate448.2PRLR, DBH, GAL, DRD4
43dopamine44 29 25 1211.2DRD4, PRL, DBH, PRLR, GAL
44dexamethasone44 50 29 1211.1PRLR, PRL, DBH, PTHLH, GAL
45alanine448.1CGB, GAL, DBH, PRLR, PTHLH
46glucose448.0PRL, GAL, DBH, PTHLH, CGB
47norepinephrine44 25 1210.0PRL, DBH, PTHLH, DRD4, GAL
48cyclic amp44 259.0CGB, GAL, DBH, PTHLH, DRD4
49serine447.9DRD4, PTHLH, DBH, PRLR, GAL
50tyrosine447.9DRD4, PRLR, PTHLH, GAL, DBH

GO Terms for genes affiliated with Hyperprolactinemia

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Cellular components related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3CGB, GAL, PRLR, PRL, DBH, PTHLH

Biological processes related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7PRLR, PRL
2female pregnancyGO:0075659.5PRL, PTHLH
3lactationGO:0075959.4PRLR, PRL
4fear responseGO:0425969.2DRD4, DBH
5behavioral response to ethanolGO:0481499.2DRD4, DBH
6response to amphetamineGO:0019759.0DBH, DRD4

Molecular functions related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1CGB, PRL, PTHLH

Products for genes affiliated with Hyperprolactinemia

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Sources for Hyperprolactinemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet