MCID: HYP020
MIFTS: 64

Hyperprolactinemia malady

Endocrine category

Summaries for Hyperprolactinemia

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

MalaCards: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to prolactinoma and adenoma. An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are Dopamine receptors and catecholamine biosynthesis. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and brain, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:64 Hyperprolactinaemia or hyperprolactinemia (HP) is the presence of abnormally high levels of prolactin in... more...

Description from OMIM:47 615555

Aliases & Classifications for Hyperprolactinemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

hyperprolactinemia 8 47 10 45 61
chiari-frommel syndrome 8 43 61
pregnancy-related a-g syndrome 8
hyperprolactinaemia 8


External Ids:

Disease Ontology8 DOID:12700
ICD1025 E22.1

Related Diseases for Hyperprolactinemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hyperprolactinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 271)
idRelated DiseaseScoreTop Affiliating Genes
1prolactinoma30.6PTHLH, POMC, TRH, SST, PRL, GH1
2adenoma30.6SRD5A1, POMC, TRH, SST, SHBG, PRLR
3systemic lupus erythematosus30.5TH, PRLR, PRL, VIP
4infertility30.5SHBG, PRLR, PRL, CGB, CGA, GNRH1
5acromegaly30.4POMC, TRH, SST, SHBG, PRLR, PRL
6amenorrhea30.4POMC, TRH, SHBG, PRL, CRH, GNRH1
7empty sella syndrome30.2PRL, GH1
8acth deficiency30.2POMC, PRL, GH1, CRH
9polycystic ovary syndrome30.2SRD5A1, SHBG, PRL, GH1, CGB5, CGA
10mccune albright syndrome30.1PRL, GH1
11anovulation30.1SRD5A1, SHBG, PRL, CGA, GNRH1
12gynecomastia30.1SRD5A1, SHBG, PRL, CGB5, CGA, GNRH1
13hyperandrogenism30.1SRD5A1, POMC, SHBG, PRL, GH1, CGB5
14fibrous dysplasia30.0GH1
15diabetes insipidus30.0POMC, TRH, PRL
16arthritis30.0POMC, GAL, VIP
17thyroiditis30.0POMC, TRH, CGA
18germinoma30.0CGB, CGB5, CGA
19uterine fibroid30.0GNRH1
20growth hormone deficiency30.0POMC, PRL, GH1, CRH
21bipolar disorder30.0TH, DRD2
22insulin resistance30.0TH, SST, SHBG, GH1
23hypoglycemia30.0DBH, POMC, TRH, SST, PRL, GH1
24pituitary tumors30.0POMC, TRH, SST, PRL, GH1, CRH
25panhypopituitarism29.9POMC, PRL, GH1
26thyrotoxicosis29.8TRH
27irritable bowel syndrome29.8CRH
28premature ovarian failure29.8GNRH1
29multiple endocrine neoplasia29.8TH, VIP
30cocaine abuse29.8DBH, DRD2
31adrenal adenoma29.8POMC, CRH
32glucose intolerance29.8SHBG, GH1
33alopecia29.8SHBG
34teratoma29.8CGB, CGB5, CGA
35ovarian hyperstimulation syndrome29.8CGB5, CGA, GNRH1
36sheehan syndrome29.8POMC, PRL, CRH
37cushing's syndrome29.8POMC, SST, GH1, CRH
38congenital adrenal hyperplasia29.8SRD5A1, POMC, CRH, GNRH1
39hyperthyroxinemia29.8TRH
40azoospermia29.8SRD5A1, SHBG, PRL, CGB5, CGA, GNRH1
41precocious puberty29.8POMC, SHBG, PRL, GH1, CGB5, CGA
42panic disorder29.8POMC, CRH
43gigantism10.2
44ahumada del castillo syndrome10.2
45mccune–albright syndrome10.1
46isolated acth deficiency10.1
47thromboembolism10.1
48pseudotumor cerebri10.0
49bipolar i disorder10.0
50galactorrhoea-hyperprolactinaemia10.0

Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Clinical Features for Hyperprolactinemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

615555

Clinical synopsis from OMIM:

615555

Drugs & Therapeutics for Hyperprolactinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperprolactinemia

Drug clinical trials:

Search ClinicalTrials for Hyperprolactinemia

Search NIH Clinical Center for Hyperprolactinemia

Search CenterWatch for Hyperprolactinemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hyperprolactinemia

Anatomical Context for Hyperprolactinemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hyperprolactinemia:

33
Ovary, Liver, Brain, Kidney, Uterus, Whole blood, Cortex, Heart, Colon, Thyroid, Adrenal gland, Breast, Prostate, Testis, Cervix, Hypothalamus, Adrenal cortex, Pineal, Pituitary, Testis germ, Testis leydig

Animal Models for Hyperprolactinemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hyperprolactinemia

Sources:
51PubMed
See all sources

Articles related to Hyperprolactinemia:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
In vitro examination of effects of hyperprolactinemia and hypoprolactinemia on seminal vesicle contractions. (23352373)
2013
2
Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin). (23968123)
2013
3
Is chronic nipple piercing associated with hyperprolactinemia? (22965248)
2013
4
Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA). (22524444)
2013
5
Investigation of impulsivity in patients on dopamine agonist therapy for hyperprolactinemia: a pilot study. (23504371)
2013
6
Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation. (23162092)
2013
7
Metoclopramide-induced hyperprolactinemia effects on the pituitary and uterine prolactin receptor expression. (23684968)
2013
8
Inhibitory effect of prolactin on Toxoplasma proliferation in peripheral blood mononuclear cells from patients with hyperprolactinemia. (22364553)
2012
9
Reversible thyrotroph hyperplasia with hyperprolactinemia: A rare presenting manifestation of primary hypothyroidism. (23226662)
2012
10
A case of hyperprolactinemia, probably induced by eletriptan. (22943929)
2012
11
Cavernous carotid artery aneurysm, a rare cause of intrasellar mass and hyperprolactinemia. (22238387)
2012
12
Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility. (23117930)
2012
13
Frequency of anticardiolipin Ac in patients with hyperprolactinemia. (22029040)
2011
14
Sexual dysfunction and hyperprolactinemia in male psychotic inpatients: a cross-sectional study. (22190916)
2011
15
A Case Report and Review of Hyperprolactinemia that is not Prolactinoma. (21672707)
2011
16
Preliminary report: a naturalistic study of the effect of aripiprazole addition on risperidone-related hyperprolactinemia in patients treated with risperidone long-acting injection. (21192158)
2011
17
Hyperprolactinemia and infertility. (22108283)
2011
18
Prevalence of hyperprolactinemia and abnormal magnetic resonance imaging findings in a population with infertility. (20116788)
2010
19
Hyperprolactinemia associated with psychotropics--a review. (20521318)
2010
20
Multiple sclerosis attacks triggered by hyperprolactinemia. (19957009)
2010
21
Differential add-on effects of aripiprazole in resolving hyperprolactinemia induced by risperidone in comparison to benzamide antipsychotics. (20732372)
2010
22
Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats. (20219648)
2010
23
A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. (18480682)
2008
24
Antipsychotic-induced hyperprolactinemia and delusion of pregnancy. (18354070)
2008
25
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia. (17187006)
2006
26
Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. (16705551)
2006
27
Macroprolactin, big-prolactin and potential effects on the misdiagnosis of hyperprolactinemia using the Beckman Coulter Access Prolactin assay. (16919253)
2006
28
Drug-induced hyperprolactinemia. (17066142)
2006
29
Hyperprolactinemia after low dose of amisulpride. (15665803)
2004
30
Aging process of epithelial cells of the rat prostate lateral lobe in experimental hyperprolactinemia induced by haloperidol. (15638391)
2004
31
Transsphenoidal (large craniopharyngeal) canal associated with a normally functioning pituitary gland and nasopharyngeal extension, hyperprolactinemia, and hypothalamic hamartoma. (12490480)
2003
32
Metoclopramide-induced hyperprolactinemia affects mouse endometrial morphology. (12592059)
2002
33
An unusual association of pemphigus vulgaris with hyperprolactinemia. (12390198)
2002
34
Effect of hyperprolactinemia induced by pituitary grafts or castration on porphyrin content of the mouse Harderian gland. (11552298)
2001
35
False hyperprolactinemia corrected by the use of heterophilic antibody-blocking agent. (11719493)
2001
36
Effect of chronic hyperprolactinemia on daily changes of glutamate and aspartate concentrations in the median eminence and different hypothalamic areas of male rats. (11023211)
2000
37
Clinical presentation of hyperprolactinemia. (10649815)
1999
38
Evaluation of semen parameters in man with hyperprolactinemia induced by metoclopramide. (9352036)
1997
39
Effect of hyperprolactinemia induced by neuroleptic agent, timiperone, on porphyrin content of mouse harderian gland. (9279824)
1997
40
Marked neonatal breast hypertrophy in a male with transient hyperprolactinemia. (8854352)
1996
41
Hyperprolactinemia in systemic lupus erythematosus? (8614774)
1996
42
A murine model of adenomyosis: the effects of hyperprolactinemia induced by fluoxetine hydrochloride, a selective serotonin reuptake inhibitor, on adenomyosis induction in Wistar albino rats. (9098464)
1995
43
Role of absorptiometry in the evaluation of bone tissue status in women with primary hyperprolactinemia]. (7653727)
1995
44
Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue Decapeptyl in girls with central precocious puberty. (7615104)
1995
45
Hyperprolactinemia in oligospermic Nigerian males: effect of bromocriptine treatment. (8012447)
1994
46
The importance of hyperprolactinemia in impotence. (8052792)
1993
47
Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia]. (1837659)
1991
48
Prolactin variants in serum and amniotic fluid of women with ovulatory hyperprolactinemia]. (1818370)
1991
49
Hyperprolactinemia in primary adrenocortical insufficiency. (2993040)
1985
50
Pregnancy associated with the empty sella syndrome and hyperprolactinemia. (761684)
1979

Genetic Variations for Hyperprolactinemia

Expression for genes affiliated with Hyperprolactinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperprolactinemia

Search GEO for disease gene expression data for Hyperprolactinemia.

Pathways for genes affiliated with Hyperprolactinemia

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DRD4, DRD2
2
Hide members
10.3DBH, TH
310.2POMC, CRH
4
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10.2PRLR, PRL, GH1
5
Development Prolactin receptor signaling
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10.2TH, PRLR, PRL
6
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10.2DRD2, DRD4, TH
710.1POMC, PRL, CGA
8
Hide members
10.1POMC, CGB, CGA
9
Hide members
10.0GNRH1, CGA, CGB, POMC
10
Hide members
10.0VIP, CRH, CGA, POMC
11
Hide members
9.1PTHLH, GNRH1, DRD2, DRD4, GAL, CRH
12
Hide members
9.0CRH, GAL, DRD4, DRD2, GNRH1, VIP

Compounds for genes affiliated with Hyperprolactinemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 281)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6SRD5A1, TRH
2forskolin45 50 1112.3POMC, CRH, GAL, DBH, TH
3allopregnanolone4510.2SRD5A1, GNRH1, POMC, GAL, SHBG
4cabergoline29 45 1112.2GNRH1, DRD2, SST, PRL, GH1, CGA
5atropine45 29 1112.2TRH, GH1, GAL
6sulpiride45 29 1112.1TRH, PRL, GH1, CGB5, CRH, DRD4
7mhpg4510.1GNRH1, CRH, PRL, DRD4, DBH, TH
8hexarelin45 2911.1GH1, POMC, CRH, SST, PRL, GAL
9pyridostigmine45 1111.1TRH, GAL, CRH, GH1, SST, PRL
10metoclopramide45 1111.1GH1, CGA, GAL, DRD2, GNRH1, PRL
11leuprolide acetate4510.0PRL, SHBG, GH1, GNRH1, CGA, CGB5
12clomiphene citrate4510.0SHBG, PRL, GH1, CGB, CGB5, CGA
13levodopa45 1111.0DBH, TRH, SST, PRL, GH1, GAL
14clonidine45 29 1112.0GAL, CGA, GH1, PRL, SST, TRH
1517-hydroxyprogesterone45 2410.9SRD5A1, POMC, SHBG, PRL, CGB5, CGA
16corticosterone45 60 2411.9POMC, PRL, GH1, CGB5, CRH, GAL
17dhea459.9CRH, CGB5, GH1, PRL, SHBG, POMC
18cocaine45 1110.9TH, DBH, POMC, TRH, PRL, CRH
19opiate459.8PRL, GH1, CGA, CRH, GAL, DRD2
20amphetamine45 1110.8TH, POMC, SST, CGB5, GAL, DRD4
21bromocriptine29 45 1111.8POMC, TRH, SST, SHBG, PRLR, PRL
22acetylcholine45 50 29 11 2413.8GAL, DRD2, CRH, GH1, PTHLH, TH
235-hydroxytryptamine459.8TH, DBH, POMC, SST, PRL, CRH
24dehydroepiandrosterone sulfate459.8SRD5A1, GNRH1, CRH, CGA, CGB5, GH1
25dihydrotestosterone45 29 11 2412.8SHBG, GH1, VIP, GNRH1, CGA, CGB5
26mifepristone45 60 29 1112.7SHBG, CRH, CGA, CGB5, CGB, PRL
27androstenedione45 2410.7CRH, GNRH1, CGA, CGB5, SRD5A1, POMC
28octreotide45 60 29 1112.7PTHLH, POMC, TRH, SST, PRL, GH1
29progestin459.7TH, SRD5A1, PTHLH, POMC, SHBG, PRLR
30acth459.7DBH, POMC, TRH, SST, PRL, GH1
31sodium nitroprusside459.7GH1, CGB5, VIP, GNRH1, CRH, CGA
32dopamine45 29 11 2412.6PRLR, CRH, DRD4, DRD2, GNRH1, SRD5A1
33naloxone45 50 29 1112.6POMC, TRH, SST, PRL, GH1, CGB5
34gnrh459.6CGB, CGA, GAL, GNRH1, VIP, PRLR
35estradiol45 11 2411.6CGB5, CGB, PRL, PRLR, SHBG, TRH
36verapamil45 50 29 11 2413.6TRH, PTHLH, GNRH1, CRH, CGA, GH1
37gaba459.6VIP, SRD5A1, TH, POMC, TRH, SST
38dexamethasone45 50 29 1112.6CGB5, CRH, GAL, GNRH1, VIP, TH
39norepinephrine45 11 2411.5DRD2, GNRH1, VIP, DRD4, GAL, PTHLH
40alanine459.5CRH, VIP, PTHLH, GAL, CGB, CGA
41lactate459.5CGA, CGB5, GH1, VIP, DBH, SST
42thyroxine45 2410.5TRH, POMC, PTHLH, SST, SHBG, GNRH1
43hydrocortisone45 2 60 1112.5POMC, CRH, GH1, PRL, SST, SHBG
44glutamate459.4PRLR, CGA, GAL, DRD4, TRH, DRD2
45progesterone45 60 29 11 2413.4PRL, GH1, CRH, PRLR, PTHLH, SRD5A1
46arginine459.3POMC, TRH, SST, SHBG, CRH, CGA
47cyclic amp45 2410.3CGB5, DRD4, VIP, GAL, DBH, TRH
48epinephrine45 11 2411.3DRD4, DRD2, GNRH1, VIP, GAL, TH
49adenylate459.1CGA, CRH, GAL, DRD4, DRD2, GNRH1
50testosterone45 60 11 2412.0CGB5, CGB, GH1, PRL, PRLR, SHBG

GO Terms for genes affiliated with Hyperprolactinemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3DBH, POMC
2secretory granuleGO:03014110.1GAL, PRL, TRH, POMC
3perikaryonGO:04320410.0TH, CRH, DRD2
4extracellular spaceGO:0056159.5GNRH1, CRH, GH1, SST, POMC, PTHLH
5extracellular regionGO:0055769.0PTHLH, VIP, GNRH1, GAL, CRH, CGA

Biological processes related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.6DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
3response to histamineGO:03477610.6DRD2, DRD4
4fear responseGO:04259610.6DRD4, DBH
5JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.6PRLR, PRL, GH1
6behavioral response to ethanolGO:04814910.6DBH, DRD4, DRD2
7norepinephrine biosynthetic processGO:04242110.6DBH, TH
8response to etherGO:04547210.5CRH, TH
9adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD2
10catecholamine biosynthetic processGO:04242310.5DBH, TH
11peptide hormone processingGO:01648610.5CGA, CGB, POMC
12feeding behaviorGO:00763110.5CRH, GAL, DRD2
13hormone-mediated apoptotic signaling pathwayGO:00862810.5CRH, SST
14ovulation cycleGO:04269810.5PRL, GNRH1
15response to corticosterone stimulusGO:05141210.5CRH, TRH, TH
16response to amphetamineGO:00197510.5DRD2, DRD4, DBH, TH
17synaptic transmission, dopaminergicGO:00196310.4TH, CRH, DRD4, DRD2
18female pregnancyGO:00756510.4PTHLH, PRL, CRH, GNRH1
19parturitionGO:00756710.4PRL, CRH
20response to estradiol stimulusGO:03235510.4TH, PRL, GH1
21dopamine metabolic processGO:04241710.4DRD4, DRD2
22locomotory behaviorGO:00762610.3DRD2, DBH, TH
23positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1
24response to ethanolGO:04547110.3GNRH1, CRH, PRL, TRH, TH
25response to drugGO:04249310.3DRD2, GAL, CRH, PRL, SST
26negative regulation of protein secretionGO:05070910.3DRD2, DRD4
27behavioral response to cocaineGO:04814810.2DRD2, DRD4
28cell-cell signalingGO:00726710.0GNRH1, CGA, CGB, SST, TRH, POMC
29response to light stimulusGO:00941610.0TH, DRD2
30signal transductionGO:0071659.8GNRH1, CRH, CGA, CGB, TRH, POMC

Molecular functions related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.3PRL, GH1
2dopamine bindingGO:03524010.1TH, DRD4, DRD2
3neuropeptide hormone activityGO:00518410.0VIP, GAL, CRH, TRH
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD4, DRD2
5hormone activityGO:0051799.5PTHLH, VIP, GNRH1, CRH, CGA, CGB

Products for genes affiliated with Hyperprolactinemia

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Sources for Hyperprolactinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet