MCID: HYP020
MIFTS: 65

Hyperprolactinemia malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases categories
Download this MalaCard

Summaries for Hyperprolactinemia

About this section
Sources:
8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

MalaCards: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to infertility and schizophrenia. An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are ErbB4 signaling events and Nuclear signaling by ERBB4. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds nemonapride and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include pituitary, breast and bone, and related mouse phenotypes are adipose tissue and reproductive system.

Wikipedia:65 Hyperprolactinaemia or hyperprolactinemia (HP) is the presence of abnormally high levels of prolactin in... more...

Description from OMIM:47 615555

Aliases & Classifications for Hyperprolactinemia

About this section
Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 62UMLS, 43NIH Rare Diseases, 49Orphanet, 58SNOMED-CT, 35MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

hyperprolactinemia 8 47 10 45 62
chiari-frommel syndrome 8 43 62
familial isolated prolactin receptor deficiency 49
pregnancy-related a-g syndrome 8
familial hyperprolactinemia 49
hyperprolactinaemia 8


External Ids:

Disease Ontology8 DOID:12700
OMIM47 615555
ICD10 via Orphanet26 E22.1
ICD1025 E22.1

Related Diseases for Hyperprolactinemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Symptoms for Hyperprolactinemia

About this section
Sources:
47OMIM
See all sources

Symptoms by clinical synopsis from OMIM:

615555

Clinical features from OMIM:

615555

Drugs & Therapeutics for Hyperprolactinemia

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hyperprolactinemia

Search NIH Clinical Center for Hyperprolactinemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hyperprolactinemia

About this section

Anatomical Context for Hyperprolactinemia

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hyperprolactinemia:

33
Pituitary, Breast, Bone, Testes, Prostate, Ovary, Thyroid, Kidney, Heart, Liver, Pineal, Hypothalamus, Cervix, Cortex, Testis, Uterus, Colon, Whole blood, Brain

Animal Models for Hyperprolactinemia or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Hyperprolactinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PRLR, DBH, PTHLH
2MP:00053898.2GAL, PRLR, PRL, PTHLH
3MP:00053918.1PTHLH, DBH, PRLR, DRD4
4MP:00053797.8PTHLH, DBH, PRL, PRLR, GAL
5MP:00107717.8PTHLH, DBH, PRL, PRLR, GAL
6MP:00053867.4GAL, DRD4, PRLR, PRL, DBH, PTHLH
7MP:00036317.4PTHLH, DBH, PRL, PRLR, DRD4, GAL
8MP:00053767.2PTHLH, DBH, PRL, PRLR, DRD4, GAL

Publications for Hyperprolactinemia

About this section
Sources:
52PubMed
See all sources

Articles related to Hyperprolactinemia:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Effect of the addition of aripiprazole on hyperprolactinemia associated with risperidone long-acting injection. (23775053)
2013
2
In vitro examination of effects of hyperprolactinemia and hypoprolactinemia on seminal vesicle contractions. (23352373)
2013
3
Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis. (23590895)
2013
4
Hyperprolactinemia in children: clinical features and long-term results. (23329759)
2012
5
Unfavorable effects of hyperprolactinemia in autoimmune endocrine disorders. (22635088)
2012
6
A case of sibutramine-induced hyperprolactinemia. (22167128)
2011
7
Frequency of anticardiolipin Ac in patients with hyperprolactinemia. (22029040)
2011
8
Treatment with aripiprazole for hyperprolactinemia induced by pituitary microadenoma in a bipolar I disorder patient. (20075655)
2010
9
Hyperprolactinemia following chronic alcohol administration. (20616493)
2010
10
Hyperprolactinemia and prolactinomas. (18226731)
2008
11
A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. (18480682)
2008
12
Hyperprolactinemia. (18404389)
2008
13
Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. (18095129)
2007
14
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia. (17187006)
2006
15
Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. (16705551)
2006
16
Macroprolactinemia in a patient with infertility and hyperprolactinemia. (17195425)
2006
17
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
18
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
19
A case of Costello with parathyroid adenoma and hyperprolactinemia. (14699620)
2004
20
Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8+ cells in vivo. (15067204)
2004
21
Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report. (15367061)
2004
22
Risperidone-induced hyperprolactinemia in an elderly woman. (12450970)
2002
23
Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. (12522680)
2002
24
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
25
Detection of macroprolactinemia with the polyethylene glycol precipitation test in systemic lupus erythematosus patients with hyperprolactinemia. (11403264)
2001
26
Changes in substance P content at the hypothalamic-pituitary axis during the Wallerian degeneration of peripheral sympathetic neurons after superior cervical ganglionectomy in male rats: effect of hyperprolactinemia. (11395934)
2001
27
Lack of association between hyperprolactinemia and colon carcinoma. (10705875)
2000
28
Paradoxical stimulation of prolactin secretion by L-dopa in metastatic prostate cancer and its possible role in prostate-cancer-related hyperprolactinemia. (10765095)
2000
29
Neuroleptic-induced hyperprolactinemia. (10190228)
1999
30
Dopaminergic modulation of hexarelin-induced GH and PRL secretion in hyperprolactinemia. (9586422)
1998
31
High association between hyperprolactinemia and anticardiolipin antibodies. (9228159)
1997
32
Hyperprolactinemia. Causes, consequences, and treatment options. (8650091)
1996
33
Two cases of alprazolam-induced hyperprolactinemia in patients with panic disorder. (8803653)
1996
34
Induction of proenkephalin in tuberoinfundibular dopaminergic neurons by hyperprolactinemia: the role of sex steroids. (7750466)
1995
35
Plasma levels of parathyroid hormone-related peptide are elevated in hyperprolactinemia and correlated to bone density status. (7639111)
1995
36
Hyperprolactinemia in oligospermic Nigerian males: effect of bromocriptine treatment. (8012447)
1994
37
Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)
1994
38
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
39
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
40
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
41
Paradoxical prolactin response to growth hormone-releasing hormone in a patient with hyperprolactinemia and empty sella. (1752237)
1991
42
The effects of pregnancy on prolactin secretion in occulted hyperprolactinemia]. (1744458)
1991
43
Hyperprolactinemia and risk for relapse of cocaine abuse. (2257288)
1990
44
The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia]. (2114023)
1990
45
Effects of gonadotropin-releasing hormone agonist and clomiphene citrate on estrogen/progesterone-induced hyperprolactinemia in monkeys. (2105248)
1990
46
Isolated ACTH deficiency associated with transient thyrotoxicosis and hyperprolactinemia. (2555145)
1989
47
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
48
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
49
Septo-optic dysplasia and median cleft face syndrome in a patient with isolated growth hormone deficiency and hyperprolactinemia. (6846278)
1983
50
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983

Variations for Hyperprolactinemia

About this section
Sources:
64UniProtKB/Swiss-Prot
See all sources

UniProtKB/Swiss-Prot genetic disease variations for Hyperprolactinemia:

64
id Symbol AA change Variation ID SNP ID
1PRLRp.His212ArgVAR_070895

Expression for genes affiliated with Hyperprolactinemia

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperprolactinemia

Search GEO for disease gene expression data for Hyperprolactinemia.

Pathways for genes affiliated with Hyperprolactinemia

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Hyperprolactinemia

About this section
Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience
See all sources

Compounds related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1nemonapride45 51 2911.9DRD4, PRL
2remoxipride45 1110.9PRL, DRD4
3terguride45 2910.8PRL, DRD4
4fluphenazine29 45 51 1112.8PRL, DRD4
5sulpiride45 29 1111.7PRL, DRD4
6hexarelin45 2910.7PRL, GAL
7pyridostigmine45 1110.7PRL, GAL
8carbidopa45 2910.6DBH, PRL
9progestin459.6PTHLH, PRL, PRLR
10lisuride45 29 1111.5DRD4, PRL
11paliperidone45 1110.5DRD4, PRL
12thyroxine45 2410.4CGB, PRL, PTHLH
13octreotide45 61 29 1112.3PTHLH, PRL, GAL
14melatonin45 29 61 24 1113.3PRL, DRD4, GAL
15maoa459.2DRD4, DBH
16mhpg459.2DRD4, PRL, DBH
17progesterone45 29 61 24 1113.0CGB, PRLR, PRL, PTHLH
18metoclopramide45 51 1111.0GAL, PRL, DBH
19clonidine45 51 29 1112.0GAL, PRL, DBH
20opiate459.0GAL, PRL, DBH
21bromocriptine45 29 1111.0PRL, PRLR, DRD4, GAL
22corticosterone45 61 2411.0DBH, PRL, GAL
23lead459.0PTHLH, DBH, DRD4
24homovanillic acid45 249.9PRL, DBH
25nicotine45 29 51 1111.9DRD4, DBH, PTHLH
26catecholamine458.9GAL, DRD4, DBH
27acth458.8GAL, PRL, DBH
28levodopa45 119.5GAL, DRD4, PRL, DBH
29cocaine45 119.5DBH, PRL, DRD4, GAL
30estradiol45 24 1110.5PTHLH, PRL, PRLR, GAL, CGB
315-hydroxytryptamine458.5GAL, DRD4, PRL, DBH
32hydrogen45 249.5GAL, PRLR, DBH, PTHLH
33epinephrine45 24 1110.5GAL, DRD4, PRL, DBH
34testosterone45 61 24 1111.5PTHLH, PRL, PRLR, GAL, CGB
35estrogen458.5PTHLH, PRL, PRLR, GAL, CGB
36gaba458.4DBH, DRD4, GAL
37sodium45 249.4GAL, DRD4, DBH, PTHLH
38adenylate458.3GAL, DRD4, DBH, PTHLH
39phosphatidylinositol458.3PTHLH, DBH, PRLR, GAL
40nitric oxide45 24 1110.3GAL, PRLR, DBH, PTHLH
41gnrh458.2CGB, GAL, PRLR, PRL, DBH
42glutamate458.2DBH, PRLR, DRD4, GAL
43dopamine45 29 24 1111.2DBH, PRL, PRLR, DRD4, GAL
44dexamethasone45 51 29 1111.1PTHLH, DBH, PRL, PRLR, GAL
45alanine458.1PTHLH, DBH, PRLR, GAL, CGB
46glucose458.0PTHLH, DBH, PRL, GAL, CGB
47norepinephrine45 24 1110.0PTHLH, DBH, PRL, DRD4, GAL
48cyclic amp45 249.0PTHLH, DBH, DRD4, GAL, CGB
49serine457.9PTHLH, DBH, PRLR, DRD4, GAL
50tyrosine457.9PTHLH, DBH, PRLR, DRD4, GAL

GO Terms for genes affiliated with Hyperprolactinemia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3CGB, GAL, PRLR, PRL, DBH, PTHLH

Biological processes related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7PRLR, PRL
2female pregnancyGO:0075659.5PRL, PTHLH
3lactationGO:0075959.4PRLR, PRL
4fear responseGO:0425969.2DRD4, DBH
5behavioral response to ethanolGO:0481499.2DRD4, DBH
6response to amphetamineGO:0019759.0DBH, DRD4

Molecular functions related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1CGB, PRL, PTHLH

Products for genes affiliated with Hyperprolactinemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperprolactinemia

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet