MCID: HYP020
MIFTS: 67

Hyperprolactinemia malady

Endocrine diseases category

Summaries for Hyperprolactinemia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

MalaCards: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to schizophrenia and infertility. An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are Dopamine receptors and catecholamine biosynthesis. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, breast and bone, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:63 Hyperprolactinaemia or hyperprolactinemia (HP) is the presence of abnormally high levels of prolactin in... more...

Description from OMIM:46 615555

Aliases & Classifications for Hyperprolactinemia

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hyperprolactinemia 8 46 10 44 60
chiari-frommel syndrome 8 42 60
pregnancy-related a-g syndrome 8
hyperprolactinaemia 8


External Ids:

Disease Ontology8 DOID:12700
ICD1025 E22.1

Related Diseases for Hyperprolactinemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperprolactinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.6TH, DBH, TRH, PRL, DRD4, DRD2
2infertility30.6SHBG, PRLR, PRL, CGB, CGA, GNRH1
3prolactinoma30.6PTHLH, POMC, TRH, SST, PRL, GH1
4adenoma30.5SRD5A1, POMC, TRH, SST, SHBG, PRLR
5hypothyroidism30.5TRH, SHBG, CGA
6systemic lupus erythematosus30.5TH, PRLR, PRL, VIP
7acromegaly30.4SST, PRL, GH1
8pituitary adenoma30.4POMC, TRH, SST, PRLR, PRL, GH1
9prostatitis30.4SRD5A1
10thyroiditis30.4POMC, TRH, CGA
11amenorrhea30.3POMC, TRH, SHBG, PRL, CRH, GNRH1
12breast cancer30.3PTHLH, SRD5A1, SHBG, PRLR, CGB, GNRH1
13obesity30.2SRD5A1, POMC, TRH, SHBG, GH1, CRH
14empty sella syndrome30.2PRL, GH1
15polycystic ovary syndrome30.2SRD5A1, SHBG, PRL, GH1, CGB5, CGA
16mccune albright syndrome30.1PRL, GH1
17endometriosis30.1PRLR, CGA, GNRH1
18multiple sclerosis30.1POMC, PRLR, DRD2
19hypertension30.1TH, DBH, POMC, CRH
20ovarian disease30.1SHBG, PRL, CGA, GNRH1
21anovulation30.1SRD5A1, SHBG, PRL, CGA, GNRH1
22gynecomastia30.1SRD5A1, SHBG, PRL, CGB5, CGA, GNRH1
23hyperandrogenism30.1SRD5A1, POMC, SHBG, PRL, GH1, CGB5
24fibrous dysplasia29.9GH1
25hypogonadotropism29.9PRL, GNRH1
26diabetes insipidus29.9POMC, TRH, PRL
27arthritis29.9POMC, GAL, VIP
28sexual disorder29.9SHBG, PRL, GNRH1
29uterine fibroid29.9GNRH1
30bipolar disorder29.9TH, DRD2
31male infertility29.9SHBG, PRL, GNRH1
32psychotic disorder29.9TH, DBH, PRL, DRD4, DRD2
33prostate cancer29.9PTHLH, SRD5A1, CGB, GNRH1
34hypoglycemia29.9DBH, POMC, TRH, SST, PRL, GH1
35hypogonadism29.9POMC, TRH, SHBG, PRL, GH1, CGB5
36hypopituitarism29.9POMC, TRH, SST, SHBG, PRL, GH1
37leiomyoma29.8GNRH1
38panhypopituitarism29.8POMC, PRL, GH1
39craniopharyngioma29.8POMC, TRH, PRL, GH1
40thyrotoxicosis29.7TRH
41constipation29.7VIP
42irritable bowel syndrome29.7CRH
43premature ovarian failure29.7GNRH1
44cocaine abuse29.7DBH, DRD2
45adrenal adenoma29.7POMC, CRH
46glucose intolerance29.7SHBG, GH1
47alopecia29.7SHBG
48ovarian hyperstimulation syndrome29.7CGB5, CGA, GNRH1
49ovarian cyst29.7CGB5, CGA, GNRH1
50migraine29.7DBH, DRD4, DRD2, VIP

Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Clinical Features for Hyperprolactinemia

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46OMIM
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Clinical features from OMIM:

615555

Clinical synopsis from OMIM:

615555

Drugs & Therapeutics for Hyperprolactinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperprolactinemia

Drug clinical trials:

Search ClinicalTrials for Hyperprolactinemia

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Search CenterWatch for Hyperprolactinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperprolactinemia

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Anatomical Context for Hyperprolactinemia

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32MalaCards
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MalaCards organs/tissues related to Hyperprolactinemia:

32
Pituitary, Breast, Bone, Testes, Prostate, Thyroid, Ovary, Kidney, Heart, Uterus, Hypothalamus, Pineal, Cervix, Colon, Liver, Testis, Brain, Whole blood, Cortex

Animal Models for Hyperprolactinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperprolactinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2SRD5A1, DBH, PRLR, GAL, DRD2
2MP:00053709.9TH, POMC, PRL, GH1, DRD2, GNRH1
3MP:00020069.8GNRH1, DRD2, PRLR, POMC
4MP:00107719.6GNRH1, DRD2, GAL, CRH, PRLR, POMC
5MP:00053899.3VIP, GNRH1, DRD2, GAL, CGA, GH1
6MP:00053869.3CRH, GAL, DRD4, DRD2, VIP, PRL
7MP:00053789.2GNRH1, DRD2, GAL, CRH, CGA, GH1
8MP:00036319.0CGA, CRH, GAL, DRD4, DRD2, GNRH1
9MP:00053769.0CGA, CRH, GAL, DRD4, DRD2, GNRH1

Publications for Hyperprolactinemia

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50PubMed
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Articles related to Hyperprolactinemia:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
A boy with prepubertal gynecomastia, hyperprolactinemia, and hypothyroidism. (23669715)
2013
2
Mutant prolactin receptor and familial hyperprolactinemia. (24195502)
2013
3
Antipsychotic-induced hyperprolactinemia and testosterone levels in boys. (22538969)
2012
4
The characteristics of acromegalic patients with hyperprolactinemia and the differences in patients with merely GH-secreting adenomas: clinical analysis of 279 cases. (22334636)
2012
5
Hyperprolactinemia and infertility: new insights. (23193578)
2012
6
Risk of hyperprolactinemia and sexual side effects in males 10-20 years old diagnosed with autism spectrum disorders or disruptive behavior disorder and treated with risperidone. (23234586)
2012
7
Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemia. (22221904)
2012
8
Ovarian tumor-derived ectopic hyperprolactinemia. (22105889)
2012
9
A case of sibutramine-induced hyperprolactinemia. (22167128)
2011
10
New Endocrine Society guidelines for hyperprolactinemia-piecing together the pituitary puzzle. (21502938)
2011
11
Clinical course of hyperprolactinemia in children and adolescents: a review of 21 cases. (21750634)
2011
12
Treatment with aripiprazole for hyperprolactinemia induced by pituitary microadenoma in a bipolar I disorder patient. (20075655)
2010
13
Hyperprolactinemia with antipsychotic drugs in children and adolescents. (20871665)
2010
14
Clinical Review#: Potential cardiac valve effects of dopamine agonists in hyperprolactinemia. (20130078)
2010
15
Dose-dependent effects of adjunctive treatment with aripiprazole on hyperprolactinemia induced by risperidone in female patients with schizophrenia. (20814333)
2010
16
Effect of hyperprolactinemia upon clinical symptoms of patients with polycystic ovary syndrome]. (20137674)
2009
17
Hyperprolactinemia and galactocele formation after augmentation mammoplasty. (19158518)
2009
18
Estimated age- and sex-specific incidence and prevalence of dopamine agonist-treated hyperprolactinemia. (19491225)
2009
19
Symptomatic hyperprolactinemia from an ectopic pituitary adenoma located in the clivus. (19289326)
2009
20
Cabergoline therapy and the risk of cardiac valve regurgitation in patients with hyperprolactinemia: a meta-analysis from clinical studies. (19246980)
2008
21
Diagnosis and management of hyperprolactinemia: expert consensus - French Society of Endocrinology. (17316545)
2007
22
Drug-induced hyperprolactinemia. (16541187)
2006
23
Sexual dysfunction in women with hyperprolactinemia: a pilot study report. (16217346)
2005
24
Persistence of hyperprolactinemia after treatment of primary hypothyroidism and withdrawal of long term use of estrogen: are the tuberoinfundibular dopaminergic neurons permanently lesioned? (16544004)
2005
25
Olanzapine-induced hyperprolactinemia and galactorrhea reversed with addition of bromocriptine: a case report. (15705020)
2005
26
Medication-induced hyperprolactinemia. (16092584)
2005
27
All the studies on hyperprolactinemia should not forget to consider the possible presence of macroprolactinemia. (14713284)
2004
28
Tumoral versus non-tumoral hyperprolactinemia in children and adolescents: possible usefulness of the domperidone test. (12713252)
2003
29
Withdrawal of long-term cabergoline therapy for tumoral and nontumoral hyperprolactinemia. (14627787)
2003
30
Hyperprolactinemia: etiology, diagnosis, and management. (12536359)
2002
31
Unusual case presentation of lichen simplex chronicus, Hodgkin's lymphoma, and nonpuerperal hyperprolactinemia-galactorrhea. (11585377)
2001
32
Pituitary adenoma associated with gigantism and hyperprolactinemia. (11786701)
2001
33
A rare cause of hyperprolactinemia: persistent trigeminal artery with stalk-section effect. (11354761)
2001
34
Lack of association between hyperprolactinemia and colon carcinoma. (10705875)
2000
35
Exposure of newborn male and female rats to environmental estrogens: delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression. (11108262)
2000
36
Migraine with ectopic hyperprolactinemia from uterine fibroids. (10891931)
2000
37
The dominant role of increased intrasellar pressure in the pathogenesis of hypopituitarism, hyperprolactinemia, and headaches in patients with pituitary adenomas. (10843153)
2000
38
Postpartum hyperprolactinemia and hyporesponsiveness of growth hormone (GH) to GH-releasing peptide. (9435424)
1998
39
Melperone treatment in an organic delusional syndrome induced by hyperprolactinemia: a case report. (9169304)
1997
40
A study of the clinical differences between women and men with hyperprolactinemia. (9032566)
1996
41
Hyperprolactinemia and galactorrhea with standard-dose famotidine therapy. (8520102)
1995
42
Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)
1994
43
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
44
Cellular and humoral immune parameters in women with pathological hyperprolactinemia before and during treatment with bromocriptine. (8166945)
1994
45
Occult hyperprolactinemia in infertile women. (8375520)
1993
46
Management of psychotropic-induced hyperprolactinemia. (1341991)
1992
47
Effects of nocturnal hyperprolactinemia on ovarian luteal function and galactorrhea. (2032589)
1991
48
Evidence for a pathological reduction in brain dopamine metabolism in idiopathic hyperprolactinemia. (1950338)
1991
49
Hyperprolactinemia and hypophyseal hypothyroidism as cofactors in hirsutism and androgen-induced alopecia in women]. (1905280)
1991
50
Septo-optic dysplasia and median cleft face syndrome in a patient with isolated growth hormone deficiency and hyperprolactinemia. (6846278)
1983

Genetic Variations for Hyperprolactinemia

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Expression for genes affiliated with Hyperprolactinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperprolactinemia

Search GEO for disease gene expression data for Hyperprolactinemia.

Pathways for genes affiliated with Hyperprolactinemia

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore
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Pathways related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DRD4, DRD2
2
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10.3DBH, TH
310.2POMC, CRH
4
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10.2PRLR, PRL, GH1
5
Development Prolactin receptor signaling
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10.2TH, PRLR, PRL
6
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10.2DRD2, DRD4, TH
710.1POMC, PRL, CGA
8
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10.1POMC, CGB, CGA
9
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10.0GNRH1, CGA, CGB, POMC
10
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10.0VIP, CRH, CGA, POMC
11
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9.1PTHLH, GNRH1, DRD2, DRD4, GAL, CRH
12
Hide members
9.0CRH, GAL, DRD4, DRD2, GNRH1, VIP

Compounds for genes affiliated with Hyperprolactinemia

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 281)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6SRD5A1, TRH
2forskolin44 49 1112.3POMC, CRH, GAL, DBH, TH
3allopregnanolone4410.2SRD5A1, GNRH1, POMC, GAL, SHBG
4cabergoline28 44 1112.2GNRH1, DRD2, SST, PRL, GH1, CGA
5atropine44 28 1112.2TRH, GH1, GAL
6sulpiride44 28 1112.1TRH, PRL, GH1, CGB5, CRH, DRD4
7mhpg4410.1GNRH1, CRH, PRL, DRD4, DBH, TH
8hexarelin44 2811.1GH1, POMC, CRH, SST, PRL, GAL
9pyridostigmine44 1111.1TRH, GAL, CRH, GH1, SST, PRL
10metoclopramide44 1111.1GH1, CGA, GAL, DRD2, GNRH1, PRL
11leuprolide acetate4410.0PRL, SHBG, GH1, GNRH1, CGA, CGB5
12clomiphene citrate4410.0SHBG, PRL, GH1, CGB, CGB5, CGA
13levodopa44 1111.0DBH, TRH, SST, PRL, GH1, GAL
14clonidine44 28 1112.0GAL, CGA, GH1, PRL, SST, TRH
1517-hydroxyprogesterone44 2410.9SRD5A1, POMC, SHBG, PRL, CGB5, CGA
16corticosterone44 59 2411.9POMC, PRL, GH1, CGB5, CRH, GAL
17dhea449.9CRH, CGB5, GH1, PRL, SHBG, POMC
18cocaine44 1110.9TH, DBH, POMC, TRH, PRL, CRH
19opiate449.8PRL, GH1, CGA, CRH, GAL, DRD2
20amphetamine44 1110.8TH, POMC, SST, CGB5, GAL, DRD4
21bromocriptine28 44 1111.8POMC, TRH, SST, SHBG, PRLR, PRL
22acetylcholine44 49 28 11 2413.8GAL, DRD2, CRH, GH1, PTHLH, TH
235-hydroxytryptamine449.8TH, DBH, POMC, SST, PRL, CRH
24dehydroepiandrosterone sulfate449.8SRD5A1, GNRH1, CRH, CGA, CGB5, GH1
25dihydrotestosterone44 28 11 2412.8SHBG, GH1, VIP, GNRH1, CGA, CGB5
26mifepristone44 59 28 1112.7SHBG, CRH, CGA, CGB5, CGB, PRL
27androstenedione44 2410.7CRH, GNRH1, CGA, CGB5, SRD5A1, POMC
28octreotide44 59 28 1112.7PTHLH, POMC, TRH, SST, PRL, GH1
29progestin449.7TH, SRD5A1, PTHLH, POMC, SHBG, PRLR
30acth449.7DBH, POMC, TRH, SST, PRL, GH1
31sodium nitroprusside449.7GH1, CGB5, VIP, GNRH1, CRH, CGA
32dopamine44 28 11 2412.6PRLR, CRH, DRD4, DRD2, GNRH1, SRD5A1
33naloxone44 49 28 1112.6POMC, TRH, SST, PRL, GH1, CGB5
34gnrh449.6CGB, CGA, GAL, GNRH1, VIP, PRLR
35estradiol44 11 2411.6CGB5, CGB, PRL, PRLR, SHBG, TRH
36verapamil44 49 28 11 2413.6TRH, PTHLH, GNRH1, CRH, CGA, GH1
37gaba449.6VIP, SRD5A1, TH, POMC, TRH, SST
38dexamethasone44 49 28 1112.6CGB5, CRH, GAL, GNRH1, VIP, TH
39norepinephrine44 11 2411.5DRD2, GNRH1, VIP, DRD4, GAL, PTHLH
40alanine449.5CRH, VIP, PTHLH, GAL, CGB, CGA
41lactate449.5CGA, CGB5, GH1, VIP, DBH, SST
42thyroxine44 2410.5TRH, POMC, PTHLH, SST, SHBG, GNRH1
43hydrocortisone44 2 59 1112.5POMC, CRH, GH1, PRL, SST, SHBG
44glutamate449.4PRLR, CGA, GAL, DRD4, TRH, DRD2
45progesterone44 59 28 11 2413.4PRL, GH1, CRH, PRLR, PTHLH, SRD5A1
46arginine449.3POMC, TRH, SST, SHBG, CRH, CGA
47cyclic amp44 2410.3CGB5, DRD4, VIP, GAL, DBH, TRH
48epinephrine44 11 2411.3DRD4, DRD2, GNRH1, VIP, GAL, TH
49adenylate449.1CGA, CRH, GAL, DRD4, DRD2, GNRH1
50testosterone44 59 11 2412.0CGB5, CGB, GH1, PRL, PRLR, SHBG

GO Terms for genes affiliated with Hyperprolactinemia

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16Gene Ontology
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Cellular components related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3DBH, POMC
2secretory granuleGO:03014110.1GAL, PRL, TRH, POMC
3perikaryonGO:04320410.0TH, CRH, DRD2
4extracellular spaceGO:0056159.5GNRH1, CRH, GH1, SST, POMC, PTHLH
5extracellular regionGO:0055769.0PTHLH, VIP, GNRH1, GAL, CRH, CGA

Biological processes related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.6DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
3response to histamineGO:03477610.6DRD2, DRD4
4fear responseGO:04259610.6DRD4, DBH
5JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.6PRLR, PRL, GH1
6behavioral response to ethanolGO:04814910.6DBH, DRD4, DRD2
7norepinephrine biosynthetic processGO:04242110.6DBH, TH
8response to etherGO:04547210.5CRH, TH
9adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD2
10catecholamine biosynthetic processGO:04242310.5DBH, TH
11peptide hormone processingGO:01648610.5CGA, CGB, POMC
12feeding behaviorGO:00763110.5CRH, GAL, DRD2
13hormone-mediated apoptotic signaling pathwayGO:00862810.5CRH, SST
14ovulation cycleGO:04269810.5PRL, GNRH1
15response to corticosterone stimulusGO:05141210.5CRH, TRH, TH
16response to amphetamineGO:00197510.5DRD2, DRD4, DBH, TH
17synaptic transmission, dopaminergicGO:00196310.4TH, CRH, DRD4, DRD2
18female pregnancyGO:00756510.4PTHLH, PRL, CRH, GNRH1
19parturitionGO:00756710.4PRL, CRH
20response to estradiol stimulusGO:03235510.4TH, PRL, GH1
21dopamine metabolic processGO:04241710.4DRD4, DRD2
22locomotory behaviorGO:00762610.3DRD2, DBH, TH
23positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1
24response to ethanolGO:04547110.3GNRH1, CRH, PRL, TRH, TH
25response to drugGO:04249310.3DRD2, GAL, CRH, PRL, SST
26negative regulation of protein secretionGO:05070910.3DRD2, DRD4
27behavioral response to cocaineGO:04814810.2DRD2, DRD4
28cell-cell signalingGO:00726710.0GNRH1, CGA, CGB, SST, TRH, POMC
29response to light stimulusGO:00941610.0TH, DRD2
30signal transductionGO:0071659.8GNRH1, CRH, CGA, CGB, TRH, POMC

Molecular functions related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.3PRL, GH1
2dopamine bindingGO:03524010.1TH, DRD4, DRD2
3neuropeptide hormone activityGO:00518410.0VIP, GAL, CRH, TRH
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD4, DRD2
5hormone activityGO:0051799.5PTHLH, VIP, GNRH1, CRH, CGA, CGB

Products for genes affiliated with Hyperprolactinemia

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Sources for Hyperprolactinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet