MCID: HYP020
MIFTS: 65

Hyperprolactinemia malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases categories

Summaries for Hyperprolactinemia

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Disease Ontology:9 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

MalaCards: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to infertility and schizophrenia. An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are ErbB4 signaling events and Nuclear signaling by ERBB4. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds nemonapride and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include pituitary, breast and bone, and related mouse phenotypes are adipose tissue and reproductive system.

Wikipedia:66 Hyperprolactinaemia or hyperprolactinemia (HP) is the presence of abnormally high levels of prolactin in... more...

Description from OMIM:48 615555

Aliases & Classifications for Hyperprolactinemia

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9Disease Ontology, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 44NIH Rare Diseases, 50Orphanet, 59SNOMED-CT, 36MeSH, 27ICD10 via Orphanet, 26ICD10
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Classifications:



Aliases & Descriptions:

hyperprolactinemia 9 48 11 46 63
chiari-frommel syndrome 9 44 63
familial isolated prolactin receptor deficiency 50
pregnancy-related a-g syndrome 9
familial hyperprolactinemia 50
hyperprolactinaemia 9


External Ids:

Disease Ontology9 DOID:12700
OMIM48 615555
ICD10 via Orphanet27 E22.1
ICD1026 E22.1

Related Diseases for Hyperprolactinemia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Symptoms for Hyperprolactinemia

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48OMIM
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Symptoms by clinical synopsis from OMIM:

615555

Clinical features from OMIM:

615555

Drugs & Therapeutics for Hyperprolactinemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Hyperprolactinemia

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Anatomical Context for Hyperprolactinemia

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34MalaCards
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MalaCards organs/tissues related to Hyperprolactinemia:

34
Pituitary, Breast, Bone, Testes, Prostate, Ovary, Thyroid, Kidney, Heart, Liver, Pineal, Hypothalamus, Cervix, Cortex, Testis, Uterus, Colon, Whole blood, Brain

Animal Models for Hyperprolactinemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hyperprolactinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PRLR, DBH, PTHLH
2MP:00053898.2GAL, PRLR, PRL, PTHLH
3MP:00053918.1PTHLH, DBH, PRLR, DRD4
4MP:00053797.8PTHLH, DBH, PRL, PRLR, GAL
5MP:00107717.8PTHLH, DBH, PRL, PRLR, GAL
6MP:00053867.4GAL, DRD4, PRLR, PRL, DBH, PTHLH
7MP:00036317.4PTHLH, DBH, PRL, PRLR, DRD4, GAL
8MP:00053767.2PTHLH, DBH, PRL, PRLR, DRD4, GAL

Publications for Hyperprolactinemia

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53PubMed
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Articles related to Hyperprolactinemia:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Effect of the addition of aripiprazole on hyperprolactinemia associated with risperidone long-acting injection. (23775053)
2013
2
In vitro examination of effects of hyperprolactinemia and hypoprolactinemia on seminal vesicle contractions. (23352373)
2013
3
Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis. (23590895)
2013
4
Hyperprolactinemia in children: clinical features and long-term results. (23329759)
2012
5
Unfavorable effects of hyperprolactinemia in autoimmune endocrine disorders. (22635088)
2012
6
A case of sibutramine-induced hyperprolactinemia. (22167128)
2011
7
Frequency of anticardiolipin Ac in patients with hyperprolactinemia. (22029040)
2011
8
Treatment with aripiprazole for hyperprolactinemia induced by pituitary microadenoma in a bipolar I disorder patient. (20075655)
2010
9
Hyperprolactinemia following chronic alcohol administration. (20616493)
2010
10
Hyperprolactinemia and prolactinomas. (18226731)
2008
11
A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. (18480682)
2008
12
Hyperprolactinemia. (18404389)
2008
13
Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. (18095129)
2007
14
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia. (17187006)
2006
15
Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. (16705551)
2006
16
Macroprolactinemia in a patient with infertility and hyperprolactinemia. (17195425)
2006
17
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
18
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
19
A case of Costello with parathyroid adenoma and hyperprolactinemia. (14699620)
2004
20
Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8+ cells in vivo. (15067204)
2004
21
Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report. (15367061)
2004
22
Risperidone-induced hyperprolactinemia in an elderly woman. (12450970)
2002
23
Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. (12522680)
2002
24
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
25
Detection of macroprolactinemia with the polyethylene glycol precipitation test in systemic lupus erythematosus patients with hyperprolactinemia. (11403264)
2001
26
Changes in substance P content at the hypothalamic-pituitary axis during the Wallerian degeneration of peripheral sympathetic neurons after superior cervical ganglionectomy in male rats: effect of hyperprolactinemia. (11395934)
2001
27
Lack of association between hyperprolactinemia and colon carcinoma. (10705875)
2000
28
Paradoxical stimulation of prolactin secretion by L-dopa in metastatic prostate cancer and its possible role in prostate-cancer-related hyperprolactinemia. (10765095)
2000
29
Neuroleptic-induced hyperprolactinemia. (10190228)
1999
30
Dopaminergic modulation of hexarelin-induced GH and PRL secretion in hyperprolactinemia. (9586422)
1998
31
High association between hyperprolactinemia and anticardiolipin antibodies. (9228159)
1997
32
Hyperprolactinemia. Causes, consequences, and treatment options. (8650091)
1996
33
Two cases of alprazolam-induced hyperprolactinemia in patients with panic disorder. (8803653)
1996
34
Induction of proenkephalin in tuberoinfundibular dopaminergic neurons by hyperprolactinemia: the role of sex steroids. (7750466)
1995
35
Plasma levels of parathyroid hormone-related peptide are elevated in hyperprolactinemia and correlated to bone density status. (7639111)
1995
36
Hyperprolactinemia in oligospermic Nigerian males: effect of bromocriptine treatment. (8012447)
1994
37
Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)
1994
38
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
39
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
40
Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia]. (1323053)
1992
41
Paradoxical prolactin response to growth hormone-releasing hormone in a patient with hyperprolactinemia and empty sella. (1752237)
1991
42
The effects of pregnancy on prolactin secretion in occulted hyperprolactinemia]. (1744458)
1991
43
Hyperprolactinemia and risk for relapse of cocaine abuse. (2257288)
1990
44
The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia]. (2114023)
1990
45
Effects of gonadotropin-releasing hormone agonist and clomiphene citrate on estrogen/progesterone-induced hyperprolactinemia in monkeys. (2105248)
1990
46
Isolated ACTH deficiency associated with transient thyrotoxicosis and hyperprolactinemia. (2555145)
1989
47
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
48
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
49
Septo-optic dysplasia and median cleft face syndrome in a patient with isolated growth hormone deficiency and hyperprolactinemia. (6846278)
1983
50
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983

Variations for Hyperprolactinemia

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65UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Hyperprolactinemia:

65
id Symbol AA change Variation ID SNP ID
1PRLRp.His212ArgVAR_070895

Expression for genes affiliated with Hyperprolactinemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperprolactinemia

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Pathways for genes affiliated with Hyperprolactinemia

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Hyperprolactinemia

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46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1nemonapride46 52 3011.9DRD4, PRL
2remoxipride46 1210.9PRL, DRD4
3terguride46 3010.8PRL, DRD4
4fluphenazine30 46 52 1212.8PRL, DRD4
5sulpiride46 30 1211.7PRL, DRD4
6hexarelin46 3010.7PRL, GAL
7pyridostigmine46 1210.7PRL, GAL
8carbidopa46 3010.6DBH, PRL
9progestin469.6PTHLH, PRL, PRLR
10lisuride46 30 1211.5DRD4, PRL
11paliperidone46 1210.5DRD4, PRL
12thyroxine46 2510.4CGB, PRL, PTHLH
13octreotide46 62 30 1212.3PTHLH, PRL, GAL
14melatonin46 30 62 25 1213.3PRL, DRD4, GAL
15maoa469.2DRD4, DBH
16mhpg469.2DRD4, PRL, DBH
17progesterone46 30 62 25 1213.0CGB, PRLR, PRL, PTHLH
18metoclopramide46 52 1211.0GAL, PRL, DBH
19clonidine46 52 30 1212.0GAL, PRL, DBH
20opiate469.0GAL, PRL, DBH
21bromocriptine46 30 1211.0PRL, PRLR, DRD4, GAL
22corticosterone46 62 2511.0DBH, PRL, GAL
23lead469.0PTHLH, DBH, DRD4
24homovanillic acid46 259.9PRL, DBH
25nicotine46 30 52 1211.9DRD4, DBH, PTHLH
26catecholamine468.9GAL, DRD4, DBH
27acth468.8GAL, PRL, DBH
28levodopa46 129.5GAL, DRD4, PRL, DBH
29cocaine46 129.5DBH, PRL, DRD4, GAL
30estradiol46 25 1210.5PTHLH, PRL, PRLR, GAL, CGB
315-hydroxytryptamine468.5GAL, DRD4, PRL, DBH
32hydrogen46 259.5GAL, PRLR, DBH, PTHLH
33epinephrine46 25 1210.5GAL, DRD4, PRL, DBH
34testosterone46 62 25 1211.5PTHLH, PRL, PRLR, GAL, CGB
35estrogen468.5PTHLH, PRL, PRLR, GAL, CGB
36gaba468.4DBH, DRD4, GAL
37sodium46 259.4GAL, DRD4, DBH, PTHLH
38adenylate468.3GAL, DRD4, DBH, PTHLH
39phosphatidylinositol468.3PTHLH, DBH, PRLR, GAL
40nitric oxide46 25 1210.3GAL, PRLR, DBH, PTHLH
41gnrh468.2CGB, GAL, PRLR, PRL, DBH
42glutamate468.2DBH, PRLR, DRD4, GAL
43dopamine46 30 25 1211.2DBH, PRL, PRLR, DRD4, GAL
44dexamethasone46 52 30 1211.1PTHLH, DBH, PRL, PRLR, GAL
45alanine468.1PTHLH, DBH, PRLR, GAL, CGB
46glucose468.0PTHLH, DBH, PRL, GAL, CGB
47norepinephrine46 25 1210.0PTHLH, DBH, PRL, DRD4, GAL
48cyclic amp46 259.0PTHLH, DBH, DRD4, GAL, CGB
49serine467.9PTHLH, DBH, PRLR, DRD4, GAL
50tyrosine467.9PTHLH, DBH, PRLR, DRD4, GAL

GO Terms for genes affiliated with Hyperprolactinemia

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17Gene Ontology
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Cellular components related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3CGB, GAL, PRLR, PRL, DBH, PTHLH

Biological processes related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7PRLR, PRL
2female pregnancyGO:0075659.5PRL, PTHLH
3lactationGO:0075959.4PRLR, PRL
4fear responseGO:0425969.2DRD4, DBH
5behavioral response to ethanolGO:0481499.2DRD4, DBH
6response to amphetamineGO:0019759.0DBH, DRD4

Molecular functions related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1CGB, PRL, PTHLH

Products for genes affiliated with Hyperprolactinemia

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Sources for Hyperprolactinemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet