MCID: HYP020
MIFTS: 67

Hyperprolactinemia malady

Endocrine diseases category

Summaries for Hyperprolactinemia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in the presence of abnormally-high levels of prolactin in the blood.

MalaCards: Hyperprolactinemia, also known as chiari-frommel syndrome, is related to schizophrenia and infertility. An important gene associated with Hyperprolactinemia is PRLR (prolactin receptor), and among its related pathways are Dopamine receptors and catecholamine biosynthesis. The drugs bromocriptine and cabergoline and the compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, breast and bone, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:63 Hyperprolactinaemia or hyperprolactinemia (HP) is the presence of abnormally high levels of prolactin in... more...

Description from OMIM:46 615555

Aliases & Classifications for Hyperprolactinemia

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hyperprolactinemia 8 46 10 44 60
chiari-frommel syndrome 8 42 60
pregnancy-related a-g syndrome 8
hyperprolactinaemia 8


External Ids:

Disease Ontology8 DOID:12700
ICD1025 E22.1

Related Diseases for Hyperprolactinemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperprolactinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.6TH, DBH, TRH, PRL, DRD4, DRD2
2infertility30.6SHBG, PRLR, PRL, CGB, CGA, GNRH1
3prolactinoma30.6PTHLH, POMC, TRH, SST, PRL, GH1
4adenoma30.5SRD5A1, POMC, TRH, SST, SHBG, PRLR
5hypothyroidism30.5TRH, SHBG, CGA
6systemic lupus erythematosus30.5TH, PRLR, PRL, VIP
7acromegaly30.4SST, PRL, GH1
8pituitary adenoma30.4POMC, TRH, SST, PRLR, PRL, GH1
9prostatitis30.4SRD5A1
10thyroiditis30.4POMC, TRH, CGA
11amenorrhea30.3POMC, TRH, SHBG, PRL, CRH, GNRH1
12breast cancer30.3PTHLH, SRD5A1, SHBG, PRLR, CGB, GNRH1
13obesity30.2SRD5A1, POMC, TRH, SHBG, GH1, CRH
14empty sella syndrome30.2PRL, GH1
15polycystic ovary syndrome30.2SRD5A1, SHBG, PRL, GH1, CGB5, CGA
16mccune albright syndrome30.1PRL, GH1
17endometriosis30.1PRLR, CGA, GNRH1
18multiple sclerosis30.1POMC, PRLR, DRD2
19hypertension30.1TH, DBH, POMC, CRH
20ovarian disease30.1SHBG, PRL, CGA, GNRH1
21anovulation30.1SRD5A1, SHBG, PRL, CGA, GNRH1
22gynecomastia30.1SRD5A1, SHBG, PRL, CGB5, CGA, GNRH1
23hyperandrogenism30.1SRD5A1, POMC, SHBG, PRL, GH1, CGB5
24fibrous dysplasia29.9GH1
25hypogonadotropism29.9PRL, GNRH1
26diabetes insipidus29.9POMC, TRH, PRL
27arthritis29.9POMC, GAL, VIP
28sexual disorder29.9SHBG, PRL, GNRH1
29uterine fibroid29.9GNRH1
30bipolar disorder29.9TH, DRD2
31male infertility29.9SHBG, PRL, GNRH1
32psychotic disorder29.9TH, DBH, PRL, DRD4, DRD2
33prostate cancer29.9PTHLH, SRD5A1, CGB, GNRH1
34hypoglycemia29.9DBH, POMC, TRH, SST, PRL, GH1
35hypogonadism29.9POMC, TRH, SHBG, PRL, GH1, CGB5
36hypopituitarism29.9POMC, TRH, SST, SHBG, PRL, GH1
37leiomyoma29.8GNRH1
38panhypopituitarism29.8POMC, PRL, GH1
39craniopharyngioma29.8POMC, TRH, PRL, GH1
40thyrotoxicosis29.7TRH
41constipation29.7VIP
42irritable bowel syndrome29.7CRH
43premature ovarian failure29.7GNRH1
44cocaine abuse29.7DBH, DRD2
45adrenal adenoma29.7POMC, CRH
46glucose intolerance29.7SHBG, GH1
47alopecia29.7SHBG
48ovarian hyperstimulation syndrome29.7CGB5, CGA, GNRH1
49ovarian cyst29.7CGB5, CGA, GNRH1
50migraine29.7DBH, DRD4, DRD2, VIP

Graphical network of the top 20 diseases related to Hyperprolactinemia:



Diseases related to hyperprolactinemia

Clinical Features for Hyperprolactinemia

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46OMIM
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Clinical features from OMIM:

615555

Clinical synopsis from OMIM:

615555

Drugs & Therapeutics for Hyperprolactinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperprolactinemia

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Anatomical Context for Hyperprolactinemia

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32MalaCards
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MalaCards organs/tissues related to Hyperprolactinemia:

32
Pituitary, Breast, Bone, Testes, Prostate, Thyroid, Ovary, Kidney, Heart, Liver, Pineal, Hypothalamus, Cervix, Cortex, Testis, Uterus, Colon, Whole blood, Brain

Animal Models for Hyperprolactinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperprolactinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2SRD5A1, DBH, PRLR, GAL, DRD2
2MP:00053709.9TH, POMC, PRL, GH1, DRD2, GNRH1
3MP:00020069.8GNRH1, DRD2, PRLR, POMC
4MP:00107719.6GNRH1, DRD2, GAL, CRH, PRLR, POMC
5MP:00053899.3VIP, GNRH1, DRD2, GAL, CGA, GH1
6MP:00053869.3CRH, GAL, DRD4, DRD2, VIP, PRL
7MP:00053789.2GNRH1, DRD2, GAL, CRH, CGA, GH1
8MP:00036319.0CGA, CRH, GAL, DRD4, DRD2, GNRH1
9MP:00053769.0CGA, CRH, GAL, DRD4, DRD2, GNRH1

Publications for Hyperprolactinemia

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50PubMed
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Articles related to Hyperprolactinemia:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
Psychotropic-induced hyperprolactinemia: a clinical review. (24140188)
2014
2
Blonanserin, a novel antipsychotic, is suitable for treating schizophrenia associated with hyperprolactinemia: a case series. (24201238)
2013
3
Hyperprolactinemia. (24347930)
2013
4
Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients. (21287295)
2012
5
Hyperprolactinemia induced by low-dosage amisulpride in Korean psychiatric patients. (22250612)
2012
6
Granulomatous cutaneous lesions associated with risperidone-induced hyperprolactinemia in an amputated upper limb. (21834946)
2012
7
Dual effects of hyperprolactinemia on carrageenan-induced inflammatory paw edema in rats. (21430396)
2011
8
Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis. (21221817)
2011
9
Comparison of cabergoline and bromocriptine in patients with asymptomatic incidental hyperprolactinemia undergoing ICSI-ET. (20459348)
2010
10
A case report of steroid cell tumour of the ovary--not otherwise specified variant with hyperandrogenism, hypercortisolism, hyperprolactinemia and hyperestrogenemia. (20608001)
2010
11
The relationship between prolactin (PRL), leptin, nitric oxide (NO), and cytokines in patients with hyperprolactinemia. (18752070)
2009
12
Insulin-like growth factor-I gene therapy reverses morphologic changes and reduces hyperprolactinemia in experimental rat prolactinomas. (18218140)
2008
13
Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. (18095129)
2007
14
Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents. (17350238)
2007
15
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
16
Reversal of symptomatic hyperprolactinemia by aripiprazole. (16055781)
2005
17
Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8+ cells in vivo. (15067204)
2004
18
Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report. (15367061)
2004
19
Hyperprolactinemia in systemic lupus erythematosus. A prospective study of 38 cases]. (15517949)
2004
20
A prospective study of hyperprolactinemia in children and adolescents treated with atypical antipsychotic agents. (15650492)
2004
21
Melatonin circadian rhythm in women with idiopathic hyperprolactinemia. (15665801)
2004
22
Daily changes of GABA and taurine concentrations in various hypothalamic areas are affected by chronic hyperprolactinemia. (12723885)
2003
23
Lack of association between hyperprolactinemia and soluble IL-2 receptor levels in systemic lupus erythematosus. (12630754)
2003
24
Hyperprolactinemia and sexual function in men: a short review. (14562140)
2003
25
Role of testicular interstitial macrophages in regulating testosterone release in hyperprolactinemia. (12577310)
2003
26
Detection of macroprolactinemia with the polyethylene glycol precipitation test in systemic lupus erythematosus patients with hyperprolactinemia. (11403264)
2001
27
Effects of hyperprolactinemia on osteoporotic fracture risk in premenopausal women. (11293923)
2001
28
Polycystic ovary syndrome and hyperprolactinemia. (11293005)
2001
29
Delayed puberty associated with hyperprolactinemia caused by pituitary microadenoma. (11045331)
2000
30
Detection of macroprolactin causing hyperprolactinemia in commercial assays for prolactin. (11106347)
2000
31
Hyperprolactinemia and erectile dysfunction. (16985734)
2000
32
New hyperprolactinemia and anovulation model in common marmoset (Callithrix jacchus) and effect of cabergoline. (10096770)
1999
33
Plasma cytokine concentration and the cytokine producing ability of whole blood cell cultures from healthy females with pharmacologically induced hyperprolactinemia. (10568223)
1999
34
Indications for hyperprolactinemia therapy. (10649816)
1999
35
Spontaneous remission in idiopathic hyperprolactinemia. (11273299)
1998
36
Hyperprolactinemia in obese as well as in lean females of Koletsky rats: effect of long lasting terguride treatment. (9951046)
1998
37
Asymptomatic 'big' hyperprolactinemia in two men with pituitary adenomas. (9461321)
1998
38
Hyperprolactinemia in males with systemic lupus erythematosus. (9858430)
1998
39
Suppressive effects of chronic hyperprolactinemia on penile erection and yawning following administration of apomorphine to pituitary-transplanted rats. (9089064)
1997
40
Hyperprolactinemia--an unusual initial manifestation of multiple sclerosis. (9286637)
1997
41
Node negative breast carcinoma: hyperprolactinemia and/or overexpression of p53 as an independent predictor of poor prognosis compared to newer and established prognosticators. (8649046)
1996
42
Identification of macroprolactin in a patient with asymptomatic hyperprolactinemia as a stable PRL-IgG complex. (7584531)
1995
43
Effects of naloxone on pulsatile luteinizing hormone in experimental hyperprolactinemia. (7900272)
1994
44
Effects of hyperprolactinemia on plasma glucose and prolactin in rats exposed to ether stress. (7972399)
1994
45
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
46
Amplification of nocturnal melatonin secretion in women with nocturnal hyperprolactinemia. (1449428)
1992
47
Is idiopathic hyperprolactinemia a transitional stage toward prolactinoma? (3114691)
1987
48
Evaluation of dopaminergic tone in hyperprolactinemia. III. Thyroid-stimulating hormone response to metoclopramide in differential diagnosis and postoperative follow-up of prolactinoma patients. (4046835)
1985
49
Primary empty sella, hyperprolactinemia, and isolated ACTH deficiency after postpartum hemorrhage. (6301277)
1983
50
Adrenogenital syndrome (11-beta-hydroxylase deficiency) with hyperprolactinemia: reversal by glucocorticoid administration. (411440)
1977

Genetic Variations for Hyperprolactinemia

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Expression for genes affiliated with Hyperprolactinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperprolactinemia

Search GEO for disease gene expression data for Hyperprolactinemia.

Pathways for genes affiliated with Hyperprolactinemia

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore
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Pathways related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DRD4, DRD2
2
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10.3DBH, TH
310.2POMC, CRH
4
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10.2PRLR, PRL, GH1
5
Development Prolactin receptor signaling
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10.2TH, PRLR, PRL
6
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10.2DRD2, DRD4, TH
710.1POMC, PRL, CGA
8
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10.1POMC, CGB, CGA
9
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10.0GNRH1, CGA, CGB, POMC
10
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10.0VIP, CRH, CGA, POMC
11
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9.1PTHLH, GNRH1, DRD2, DRD4, GAL, CRH
12
Hide members
9.0CRH, GAL, DRD4, DRD2, GNRH1, VIP

Compounds for genes affiliated with Hyperprolactinemia

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 281)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6SRD5A1, TRH
2forskolin44 49 1112.3POMC, CRH, GAL, DBH, TH
3allopregnanolone4410.2SRD5A1, GNRH1, POMC, GAL, SHBG
4cabergoline28 44 1112.2GNRH1, DRD2, SST, PRL, GH1, CGA
5atropine44 28 1112.2TRH, GH1, GAL
6sulpiride44 28 1112.1TRH, PRL, GH1, CGB5, CRH, DRD4
7mhpg4410.1GNRH1, CRH, PRL, DRD4, DBH, TH
8hexarelin44 2811.1GH1, POMC, CRH, SST, PRL, GAL
9pyridostigmine44 1111.1TRH, GAL, CRH, GH1, SST, PRL
10metoclopramide44 1111.1GH1, CGA, GAL, DRD2, GNRH1, PRL
11leuprolide acetate4410.0PRL, SHBG, GH1, GNRH1, CGA, CGB5
12clomiphene citrate4410.0SHBG, PRL, GH1, CGB, CGB5, CGA
13levodopa44 1111.0DBH, TRH, SST, PRL, GH1, GAL
14clonidine44 28 1112.0GAL, CGA, GH1, PRL, SST, TRH
1517-hydroxyprogesterone44 2410.9SRD5A1, POMC, SHBG, PRL, CGB5, CGA
16corticosterone44 59 2411.9POMC, PRL, GH1, CGB5, CRH, GAL
17dhea449.9CRH, CGB5, GH1, PRL, SHBG, POMC
18cocaine44 1110.9TH, DBH, POMC, TRH, PRL, CRH
19opiate449.8PRL, GH1, CGA, CRH, GAL, DRD2
20amphetamine44 1110.8TH, POMC, SST, CGB5, GAL, DRD4
21bromocriptine28 44 1111.8POMC, TRH, SST, SHBG, PRLR, PRL
22acetylcholine44 49 28 11 2413.8GAL, DRD2, CRH, GH1, PTHLH, TH
235-hydroxytryptamine449.8TH, DBH, POMC, SST, PRL, CRH
24dehydroepiandrosterone sulfate449.8SRD5A1, GNRH1, CRH, CGA, CGB5, GH1
25dihydrotestosterone44 28 11 2412.8SHBG, GH1, VIP, GNRH1, CGA, CGB5
26mifepristone44 59 28 1112.7SHBG, CRH, CGA, CGB5, CGB, PRL
27androstenedione44 2410.7CRH, GNRH1, CGA, CGB5, SRD5A1, POMC
28octreotide44 59 28 1112.7PTHLH, POMC, TRH, SST, PRL, GH1
29progestin449.7TH, SRD5A1, PTHLH, POMC, SHBG, PRLR
30acth449.7DBH, POMC, TRH, SST, PRL, GH1
31sodium nitroprusside449.7GH1, CGB5, VIP, GNRH1, CRH, CGA
32dopamine44 28 11 2412.6PRLR, CRH, DRD4, DRD2, GNRH1, SRD5A1
33naloxone44 49 28 1112.6POMC, TRH, SST, PRL, GH1, CGB5
34gnrh449.6CGB, CGA, GAL, GNRH1, VIP, PRLR
35estradiol44 11 2411.6CGB5, CGB, PRL, PRLR, SHBG, TRH
36verapamil44 49 28 11 2413.6TRH, PTHLH, GNRH1, CRH, CGA, GH1
37gaba449.6VIP, SRD5A1, TH, POMC, TRH, SST
38dexamethasone44 49 28 1112.6CGB5, CRH, GAL, GNRH1, VIP, TH
39norepinephrine44 11 2411.5DRD2, GNRH1, VIP, DRD4, GAL, PTHLH
40alanine449.5CRH, VIP, PTHLH, GAL, CGB, CGA
41lactate449.5CGA, CGB5, GH1, VIP, DBH, SST
42thyroxine44 2410.5TRH, POMC, PTHLH, SST, SHBG, GNRH1
43hydrocortisone44 2 59 1112.5POMC, CRH, GH1, PRL, SST, SHBG
44glutamate449.4PRLR, CGA, GAL, DRD4, TRH, DRD2
45progesterone44 59 28 11 2413.4PRL, GH1, CRH, PRLR, PTHLH, SRD5A1
46arginine449.3POMC, TRH, SST, SHBG, CRH, CGA
47cyclic amp44 2410.3CGB5, DRD4, VIP, GAL, DBH, TRH
48epinephrine44 11 2411.3DRD4, DRD2, GNRH1, VIP, GAL, TH
49adenylate449.1CGA, CRH, GAL, DRD4, DRD2, GNRH1
50testosterone44 59 11 2412.0CGB5, CGB, GH1, PRL, PRLR, SHBG

GO Terms for genes affiliated with Hyperprolactinemia

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16Gene Ontology
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Cellular components related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3DBH, POMC
2secretory granuleGO:03014110.1GAL, PRL, TRH, POMC
3perikaryonGO:04320410.0TH, CRH, DRD2
4extracellular spaceGO:0056159.5GNRH1, CRH, GH1, SST, POMC, PTHLH
5extracellular regionGO:0055769.0PTHLH, VIP, GNRH1, GAL, CRH, CGA

Biological processes related to Hyperprolactinemia according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.6DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
3response to histamineGO:03477610.6DRD2, DRD4
4fear responseGO:04259610.6DRD4, DBH
5JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.6PRLR, PRL, GH1
6behavioral response to ethanolGO:04814910.6DBH, DRD4, DRD2
7norepinephrine biosynthetic processGO:04242110.6DBH, TH
8response to etherGO:04547210.5CRH, TH
9adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD2
10catecholamine biosynthetic processGO:04242310.5DBH, TH
11peptide hormone processingGO:01648610.5CGA, CGB, POMC
12feeding behaviorGO:00763110.5CRH, GAL, DRD2
13hormone-mediated apoptotic signaling pathwayGO:00862810.5CRH, SST
14ovulation cycleGO:04269810.5PRL, GNRH1
15response to corticosterone stimulusGO:05141210.5CRH, TRH, TH
16response to amphetamineGO:00197510.5DRD2, DRD4, DBH, TH
17synaptic transmission, dopaminergicGO:00196310.4TH, CRH, DRD4, DRD2
18female pregnancyGO:00756510.4PTHLH, PRL, CRH, GNRH1
19parturitionGO:00756710.4PRL, CRH
20response to estradiol stimulusGO:03235510.4TH, PRL, GH1
21dopamine metabolic processGO:04241710.4DRD4, DRD2
22locomotory behaviorGO:00762610.3DRD2, DBH, TH
23positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1
24response to ethanolGO:04547110.3GNRH1, CRH, PRL, TRH, TH
25response to drugGO:04249310.3DRD2, GAL, CRH, PRL, SST
26negative regulation of protein secretionGO:05070910.3DRD2, DRD4
27behavioral response to cocaineGO:04814810.2DRD2, DRD4
28cell-cell signalingGO:00726710.0GNRH1, CGA, CGB, SST, TRH, POMC
29response to light stimulusGO:00941610.0TH, DRD2
30signal transductionGO:0071659.8GNRH1, CRH, CGA, CGB, TRH, POMC

Molecular functions related to Hyperprolactinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.3PRL, GH1
2dopamine bindingGO:03524010.1TH, DRD4, DRD2
3neuropeptide hormone activityGO:00518410.0VIP, GAL, CRH, TRH
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD4, DRD2
5hormone activityGO:0051799.5PTHLH, VIP, GNRH1, CRH, CGA, CGB

Products for genes affiliated with Hyperprolactinemia

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Sources for Hyperprolactinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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39NCIt
40NDF-RT
43NINDS
44Novoseek
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