MCID: HYP729
MIFTS: 31

Hypersensitivity Reaction Disease

Categories: Immune diseases, Cancer diseases

Aliases & Classifications for Hypersensitivity Reaction Disease

MalaCards integrated aliases for Hypersensitivity Reaction Disease:

Name: Hypersensitivity Reaction Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060056

Summaries for Hypersensitivity Reaction Disease

Disease Ontology : 12 An immune system disease that has material basis in abnormal immune responses.

MalaCards based summary : Hypersensitivity Reaction Disease is related to selective igg deficiency disease and c1q nephropathy. An important gene associated with Hypersensitivity Reaction Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Hypersensitivity Reaction Disease

Diseases in the Hypersensitivity Reaction Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 selective igg deficiency disease 10.8 CD40LG CD79A
2 c1q nephropathy 10.8 CD40LG CD79A
3 gluten allergy 10.8 CD79A TGM2
4 transient neonatal thrombocytopenia 10.8 CD79A TRIM21
5 meningovascular neurosyphilis 10.8 CD40LG CD79A
6 alpha chain disease 10.8 CD40LG CD79A
7 brill-zinsser disease 10.8 CD40LG CD79A
8 ocular toxoplasmosis 10.8 CD40LG CD79A TLR9
9 exudative glomerulonephritis 10.8 CD40LG CD79A
10 cork-handlers' disease 10.8 CD40LG CD79A
11 endocrine exophthalmos 10.8 CD40LG TG
12 hyperglobulinemic purpura 10.8 CD40LG CD79A TRIM21
13 punctate inner choroidopathy 10.8 IL10 TNF
14 salpingo-oophoritis 10.8 CD40LG CD79A
15 parasitic ichthyosporea infectious disease 10.8 CD40LG CD79A IL4
16 congenital hypogammaglobulinemia 10.8 CD40LG CD79A IL4
17 rhinosporidiosis 10.8 CD40LG CD79A IL4
18 central nervous system vasculitis 10.8 CD40LG TLR9 TNF
19 early yaws 10.8 CD40LG CD79A
20 wheat allergy 10.8 CD79A TGM2 TOR1A
21 ventilation pneumonitis 10.8 CD40LG CD79A
22 ross river fever 10.8 CD40LG IL10
23 salivary gland disease 10.8 CD40LG CD79A TRIM21
24 osteosclerotic myeloma 10.8 CD40LG CD79A TNF
25 chronic interstitial cystitis 10.8 CD40LG CD79A
26 immunodeficiency with hyper-igm, type 1 10.8 CD40LG CD79A IL4
27 jejunoileitis 10.8 CD40LG CD79A TNF
28 axillary adenitis 10.8 CD40LG CD79A
29 sporotrichosis 10.8 CD40LG CD79A IL10
30 lymphoepithelioma-like thymic carcinoma 10.8 FOXP3 TG
31 acute salpingitis 10.8 CD40LG CD79A TNF
32 syphilis 10.8 APOH CD40LG CD79A
33 monoclonal gammopathy of uncertain significance 10.8 CD40LG CD79A TNF
34 cryofibrinogenemia 10.8 CD40LG CD79A
35 hypersensitivity vasculitis 10.8 CD40LG CD79A MEFV
36 pneumocystosis 10.8 CD40LG CD79A TNF
37 hypersensitivity reaction type iii disease 10.8 CD40LG CD79A MEFV
38 meningoencephalitis 10.8 CD40LG CD79A TLR9
39 pustulosis palmaris et plantaris 10.8 CD40LG CD79A TNF
40 henoch-schoenlein purpura 10.8 CD40LG CD79A MEFV
41 congenital syphilis 10.8 CD40LG CD79A DDX41
42 cardiovascular syphilis 10.8 CD40LG DDX41
43 microscopic colitis 10.8 CD79A IL4 TNF
44 mature b-cell neoplasm 10.8 CD40LG CD79A TLR9
45 taeniasis 10.8 CD40LG CD79A IL10
46 secondary syphilis 10.8 CD40LG CD79A DDX41
47 byssinosis 10.8 CD40LG CD79A MEFV
48 chronic salpingitis 10.8 CD40LG CD79A TNF
49 conjunctival disease 10.8 CD40LG CD79A IL4
50 orbital granuloma 10.8 CD40LG CD79A PRTN3

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Disease:



Diseases related to Hypersensitivity Reaction Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Disease

MGI Mouse Phenotypes related to Hypersensitivity Reaction Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.33 MEFV FOXP3 PRTN3 SCHIP1 IL10 CD40LG
2 homeostasis/metabolism MP:0005376 10.27 MEFV FOXP3 SCHIP1 IL10 APOH CD40LG
3 hematopoietic system MP:0005397 10.25 CD79A MEFV FOXP3 PRTN3 IL10 CD40LG
4 immune system MP:0005387 10.17 CD79A MEFV FOXP3 PRTN3 IL10 CD40LG
5 endocrine/exocrine gland MP:0005379 10.13 IL4 FOXP3 IL10 CD40LG TSHR TNF
6 mortality/aging MP:0010768 10.03 DDX41 MEFV FOXP3 SCHIP1 APOH IL10
7 liver/biliary system MP:0005370 9.8 IL4 CD79A MEFV FOXP3 IL10 TRPV1
8 no phenotypic analysis MP:0003012 9.56 IL4 CD79A PRTN3 FOXP3 IL10 TGM2
9 renal/urinary system MP:0005367 9.28 CD79A FOXP3 CD40LG IL4 TRPV1 TLR9

Drugs & Therapeutics for Hypersensitivity Reaction Disease

Search Clinical Trials , NIH Clinical Center for Hypersensitivity Reaction Disease

Genetic Tests for Hypersensitivity Reaction Disease

Anatomical Context for Hypersensitivity Reaction Disease

Publications for Hypersensitivity Reaction Disease

Variations for Hypersensitivity Reaction Disease

Expression for Hypersensitivity Reaction Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Disease.

Pathways for Hypersensitivity Reaction Disease

Pathways related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD40LG IL10 IL4 PRTN3 TNF TNFRSF25
2
Show member pathways
12.54 CD40LG FOXP3 IL10 IL4 TG TNF
3
Show member pathways
12.5 CD40LG CD79A IL10 IL4 TNF
4
Show member pathways
12.32 CD40LG IL10 IL4 TNF
5
Show member pathways
12.11 CD40LG IL10 IL4 TNF
6 12.07 CD40LG CD79A FOXP3 IL10 IL4 TLR9
7 11.77 CD79A IL10 IL4 TNF
8
Show member pathways
11.68 CD40LG TNF TNFRSF25
9 11.66 IL10 IL4 TNF
10 11.62 IL10 TLR9 TNF
11
Show member pathways
11.61 CD40LG TNF TNFRSF25
12 11.53 CD40LG IL10 IL4
13
Show member pathways
11.5 CD40LG FOXP3 IL4 TNF
14 11.36 IL10 IL4 TNF
15 11.32 FOXP3 IL10 IL4
16
Show member pathways
11.19 FOXP3 IL10 TNF
17 11.15 IL10 TLR9 TNF
18 11.15 CD40LG IL10 TLR9 TNF
19 11.06 CD40LG IL10 IL4 TNF
20 11.02 IL10 IL4 TNF
21 10.92 CD40LG FOXP3 IL10 IL4 TLR9 TNF
22 10.29 TG TSHR

GO Terms for Hypersensitivity Reaction Disease

Cellular components related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 APOH CD40LG IL10 IL4 PRTN3 TG
2 external side of plasma membrane GO:0009897 9.46 CD40LG CD79A TNF TRPV1
3 extracellular region GO:0005576 9.32 APOH CD40LG COL17A1 IL10 IL4 PRTN3

Biological processes related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CD40LG IL10 IL4 TNF TNFRSF25
2 regulation of receptor activity GO:0010469 9.92 CD40LG IL10 IL4 TG TNF
3 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.71 FOXP3 TLR9 TRIM21
4 inflammatory response GO:0006954 9.7 CD40LG IL10 MEFV TLR9 TNF TNFRSF25
5 response to molecule of bacterial origin GO:0002237 9.58 IL10 TLR9
6 negative regulation of interleukin-12 production GO:0032695 9.57 IL10 MEFV
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
8 endothelial cell apoptotic process GO:0072577 9.51 IL10 TNF
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.49 IL10 IL4
10 negative regulation of cytokine secretion involved in immune response GO:0002740 9.48 IL10 TNF
11 type 2 immune response GO:0042092 9.46 IL10 IL4
12 negative regulation of interleukin-8 production GO:0032717 9.43 IL10 TLR9
13 B cell proliferation GO:0042100 9.43 CD40LG CD79A IL10
14 regulation of immunoglobulin secretion GO:0051023 9.4 CD40LG TNF
15 regulation of isotype switching GO:0045191 9.37 IL10 IL4
16 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
17 negative regulation of interleukin-6 production GO:0032715 9.26 FOXP3 IL10 TLR9 TNF
18 B cell differentiation GO:0030183 9.02 CD40LG CD79A IL10 IL4 TSHR

Molecular functions related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CD40LG IL10 IL4 TNF

Sources for Hypersensitivity Reaction Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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