MCID: HYP729
MIFTS: 43

Hypersensitivity Reaction Disease

Categories: Immune diseases, Cancer diseases

Aliases & Classifications for Hypersensitivity Reaction Disease

MalaCards integrated aliases for Hypersensitivity Reaction Disease:

Name: Hypersensitivity Reaction Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060056

Summaries for Hypersensitivity Reaction Disease

Disease Ontology : 12 An immune system disease that has material basis in abnormal immune responses.

MalaCards based summary : Hypersensitivity Reaction Disease is related to alcoholic neuropathy and calloso-genital dysplasia. An important gene associated with Hypersensitivity Reaction Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Citalopram and Reboxetine have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and lung, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Hypersensitivity Reaction Disease

Diseases in the Hypersensitivity Reaction Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease
Hypersensitivity Reaction Type Ii Disease

Diseases related to Hypersensitivity Reaction Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
id Related Disease Score Top Affiliating Genes
1 alcoholic neuropathy 11.2 CD40LG CD79A
2 calloso-genital dysplasia 11.2 CD40LG CD79A
3 cutaneous t cell lymphoma 11.2 CD79A TGM2
4 senile atrophy of choroid 11.2 CD79A TRIM21
5 variola major 11.2 CD40LG CD79A
6 mu chain disease 11.2 CD40LG CD79A
7 rabies 11.2 CD40LG CD79A
8 familial retinoblastoma 11.2 CD40LG CD79A
9 oculo-cerebral dysplasia 11.2 CD40LG CD79A TLR9
10 anti-basement membrane glomerulonephritis 11.2 CD40LG CD79A
11 microinvasive cervical squamous cell carcinoma 11.2 CD40LG CD79A
12 thyrotoxic exophthalmos 11.2 CD40LG TG
13 benign epilepsy with centrotemporal spikes 11.2 CD40LG CD79A TRIM21
14 fetal erythroblastosis 11.2 CD40LG CD79A
15 pure autonomic failure 11.2 IL10 TNF
16 spinal canal and spinal cord meningioma 11.2 CD40LG CD79A
17 trichostrongyloidiasis 11.1 CD40LG CD79A
18 aniseikonia 11.1 CD40LG CD79A IL4
19 polyneuropathy due to drug 11.1 CD40LG CD79A IL4
20 cutaneous ganglioneuroma 11.1 CD40LG CD79A IL4
21 balkan hemorrhagic fever 11.1 CD40LG IL10
22 central nervous system leiomyosarcoma 11.1 CD40LG TLR9 TNF
23 diffuse cutaneous mastocytosis 11.1 CD79A TGM2 TOR1A
24 hypoparathyroidism, x-linked 11.1 CD40LG CD79A IL4
25 leukodystrophy 11.1 CD40LG CD79A
26 uveitis 11.1 CD40LG CD79A TNF
27 partial third-nerve palsy 11.1 CD40LG CD79A TRIM21
28 retinal microaneurysm 11.1 CD40LG CD79A
29 indolent myeloma 11.1 CD40LG CD79A TNF
30 ileocolitis 11.1 CD40LG CD79A TNF
31 blood group incompatibility 11.1 APOH CD40LG CD79A
32 heart septal defect 11.1 CD40LG CD79A
33 partial circumpapillary choroid dystrophy 11.1 CD40LG CD79A MEFV
34 dumping syndrome 11.1 CD40LG CD79A IL10
35 cryptorchidism arachnodactyly mental retardation 11.1 CD40LG CD79A
36 discitis 11.1 CD40LG CD79A TNF
37 hypogonadotropism 11.1 CD40LG CD79A TNF
38 rectum malignant melanoma 11.1 CD40LG DDX41
39 intracortical osteogenic sarcoma 11.1 FOXP3 TG
40 alopecia areata 11.1 CD40LG CD79A DDX41
41 bladder diverticulum 11.1 CD40LG CD79A TNF
42 late yaws 11.1 CD40LG CD79A TLR9
43 pyridoxine deficiency 11.1 CD40LG CD79A TNF
44 median arcuate ligament syndrome 11.1 CD40LG DDX41
45 angiomyoma 11.1 CD40LG CD79A IL4
46 malignant melanocytic peripheral nerve sheath tumor of mediastinum 11.1 CD40LG CD79A TLR9
47 dislocation of ear ossicle 11.1 CD40LG CD79A MEFV
48 cerebral neuroblastoma 11.1 CD40LG CD79A DDX41
49 lymphocytic colitis 11.1 CD79A IL4 TNF
50 fibrosarcomatous osteosarcoma 11.1 CD79A TLR9 TRPV1

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Disease:



Diseases related to Hypersensitivity Reaction Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Disease

MGI Mouse Phenotypes related to Hypersensitivity Reaction Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 IL10 IL4 MEFV PRTN3 SCHIP1 TGM2
2 homeostasis/metabolism MP:0005376 10.27 APOH CD40LG CD79A FOXP3 IL10 IL4
3 hematopoietic system MP:0005397 10.25 IL10 IL4 MEFV PRTN3 TG TGM2
4 immune system MP:0005387 10.17 CD40LG CD79A FOXP3 IL10 IL4 MEFV
5 endocrine/exocrine gland MP:0005379 10.13 CD40LG FOXP3 IL10 IL4 SCHIP1 TG
6 mortality/aging MP:0010768 10.03 APOH CD40LG DDX41 FOXP3 IL10 IL4
7 liver/biliary system MP:0005370 9.8 MEFV TNF TRPV1 CD79A FOXP3 IL10
8 no phenotypic analysis MP:0003012 9.56 CD79A FOXP3 IL10 IL4 PRTN3 TGM2
9 renal/urinary system MP:0005367 9.28 FOXP3 IL4 SCHIP1 TGM2 TLR9 TRIM21

Drugs & Therapeutics for Hypersensitivity Reaction Disease

Drugs for Hypersensitivity Reaction Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1746)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1 59729-33-8 2771
2
Reboxetine Approved, Investigational Phase 4 98769-81-4, 71620-89-8 123628 65856
3
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
4
Memantine Approved, Investigational Phase 4,Phase 2 19982-08-2 4054
5
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
6
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
7
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Phase 1 10102-43-9 145068
8
Simvastatin Approved Phase 4,Phase 2,Phase 3,Phase 1 79902-63-9 54454
9
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 159351-69-6 6442177
10
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53123-88-9 5284616 6436030 46835353
11
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-78-2 2244
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
13
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
14
Levodopa Approved Phase 4,Phase 3,Phase 1 59-92-7 6047
15
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 73590-58-6 4594
16
Amlodipine Approved Phase 4,Phase 3,Phase 2,Phase 1 88150-42-9 2162
17
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 58-93-5 3639
18
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137862-53-4 60846
19
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
20
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 26787-78-0 33613 2171
21
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Phase 1 85721-33-1 2764
22
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
23
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
24
Guaifenesin Approved, Vet_approved Phase 4,Phase 2,Phase 1 93-14-1 3516
25
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
26
Pancrelipase Approved Phase 4,Phase 2,Phase 1,Early Phase 1 53608-75-6
27
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51333-22-3 63006 5281004
28
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
29
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
30
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 54910-89-3 3386
31
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
32
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1 79617-96-2 68617
33
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
34
Meropenem Approved, Investigational Phase 4,Phase 3 119478-56-7 64778 441130
35
Piperacillin Approved Phase 4,Phase 3 66258-76-2 43672
36
Tazobactam Approved Phase 4,Phase 3 89786-04-9 123630
37
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 441141 14969
38
Bambuterol Approved Phase 4 81732-65-2, 81732-46-9 54766
39
Terbutaline Approved Phase 4,Phase 3 23031-25-6 5403
40
Ramipril Approved Phase 4,Phase 3,Phase 2,Early Phase 1 87333-19-5 5362129
41
Telmisartan Approved, Investigational Phase 4,Phase 3,Phase 2 144701-48-4 65999
42
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
43
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1 616-91-1 12035
44
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 55-56-1 9552079 2713
45
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
46
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
47
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
48
Atenolol Approved Phase 4,Phase 2 29122-68-7 2249
49
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
50
Peginterferon alfa-2b Approved Phase 4,Phase 3,Phase 2,Phase 1 99210-65-8, 215647-85-1

Interventional clinical trials:

(show top 50) (show all 10000)

id Name Status NCT ID Phase Drugs
1 Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Unknown status NCT01678599 Phase 4 Benznidazole
2 Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
3 Study of Memantine to Treat Huntington's Disease Unknown status NCT00652457 Phase 4 Memantine
4 Ocular Allergy Treatment Practical Impact Trial Unknown status NCT01808768 Phase 4 Alcaftadine
5 Effect of Doxium on High Sensitivity CRP and Endothelin-1 Serum Levels in Patients With Diabetic Retinopathy Unknown status NCT01382498 Phase 4 Calcium dobesilate (Doxium);Placebo drug
6 Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma Unknown status NCT00500253 Phase 4
7 Simvastatin in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00680641 Phase 4 Simvastatin;Placebo
8 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
9 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
10 A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer SES Safety and Effectiveness in CAD Treatment Unknown status NCT01880879 Phase 4
11 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
12 Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients Unknown status NCT01198379 Phase 4 aspirin;Placebo
13 Assessment of Surface Coverage of Two Types of DES in Diabetes Mellitus and Non- Diabetes Mellitus Unknown status NCT01023919 Phase 4
14 Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes Unknown status NCT01153243 Phase 4 Ergocalciferol;Placebo pill
15 Exhaled NO Based Treatment of Chronic Obstructive Pulmonary Disease (COPD), ICS/LABA Versus LAMA Unknown status NCT02546349 Phase 4 fluticasone/salmeterol, tiotropium
16 Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients Unknown status NCT01780467 Phase 4
17 Comparison of Diabetes Mellitus and Non-diabetes Mellitus Patients for DES Surface COVERage by OCT Unknown status NCT01021930 Phase 4
18 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
19 Associated Genes With Atomoxetine Response in Attention Deficit Hyperactivity Disorder (ADHD) Unknown status NCT01339286 Phase 4 atomoxetine
20 Regression of Fatty Heart by Valsartan Therapy Unknown status NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
21 Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
22 Diverticulitis: Antibiotics or Close Observation? Unknown status NCT01111253 Phase 4 Amoxicillin-clavulanate
23 Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
24 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
25 Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
26 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
27 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
28 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
29 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
30 The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
31 Telmisartan Versus Ramipril After Acute Coronary Syndrome Unknown status NCT00702936 Phase 4 TELMISARTAN;RAMIPRIL
32 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
33 Changes in Electroretinogram and Contrast Sensitivity After PASCAL Treatment Unknown status NCT00563043 Phase 4
34 Positron Emission Tomography (PET)/Computed Tomography (CT) and Roentgen in Lung Cancer: Evaluation of Patients in General Practice Unknown status NCT00675168 Phase 4
35 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
36 Prospective Randomized Trial On RadiaTion Dose Estimates Of CT AngIOgraphy In PatieNts Scanned With A 100kV Protocol Unknown status NCT00611780 Phase 4
37 Prospective Randomized Trial On RadiaTion Dose Estimates Of CT AngIOgraphy In PatieNts Scanned With A Sequential Scan Protocol Unknown status NCT00612092 Phase 4
38 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
39 Safety of Ertapenem in Beta-lactam Allergic Patients. Unknown status NCT01159379 Phase 4 ertapenem
40 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
41 Use TST and QFT-RD1 Test to Monitor the Tuberculous Infection in Patients, Close Contact People and Health Care Workers Unknown status NCT00311220 Phase 4 tuberculin for skin test
42 Trial on the Efficacy of Tegaderm Chlorhexidine Gluconate (CHG) in Reducing Catheter Related Bloodstream Infections Unknown status NCT01142934 Phase 4
43 Vitamin D and Glucose Metabolism in Pediatrics Unknown status NCT01386736 Phase 4 Vitamin D drops;Placebo drops
44 Odense Androgen Study - The Effect of Testim and Training in Hypogonadal Men Unknown status NCT00700024 Phase 4 Testim;placebo
45 Study of Chlorhexidine as the Hub Antiseptic to Prevent Catheter Related Infections in Newborn Infants Unknown status NCT00516360 Phase 4
46 Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes Unknown status NCT00925119 Phase 4 Atenolol
47 Interferon and Ribavirin Treatment in Patients With Hemoglobinopathies Unknown status NCT00887081 Phase 4 PEG-IFN alpha2a or PEG-IFN alpha2b and Ribavirin
48 Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia Unknown status NCT01789294 Phase 4 Mesalamine
49 Fludrocortisone's Test in Salt Sensitivity Unknown status NCT01453959 Phase 4 Fludrocortisone
50 Targeted Indoor Residual Spraying Against Malaria Unknown status NCT02556242 Phase 4

Search NIH Clinical Center for Hypersensitivity Reaction Disease

Genetic Tests for Hypersensitivity Reaction Disease

Anatomical Context for Hypersensitivity Reaction Disease

MalaCards organs/tissues related to Hypersensitivity Reaction Disease:

39
Testes, Breast, Lung, Skin, Liver, Prostate, Heart

Publications for Hypersensitivity Reaction Disease

Variations for Hypersensitivity Reaction Disease

Expression for Hypersensitivity Reaction Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Disease.

Pathways for Hypersensitivity Reaction Disease

Pathways related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 CD40LG FOXP3 IL10 IL4 TG TNF
2
Show member pathways
12.5 CD40LG CD79A IL10 IL4 TNF
3
Show member pathways
12.11 CD40LG IL10 IL4 TNF
4 12.05 CD40LG CD79A FOXP3 IL10 IL4 TLR9
5 11.77 CD79A IL10 IL4 TNF
6
Show member pathways
11.7 CD40LG TNF TNFRSF25
7 11.66 IL10 IL4 TNF
8 11.63 IL10 TLR9 TNF
9
Show member pathways
11.61 CD40LG TNF TNFRSF25
10 11.53 CD40LG IL10 IL4
11
Show member pathways
11.5 CD40LG FOXP3 IL4 TNF
12 11.36 IL10 IL4 TNF
13 11.33 FOXP3 IL10 IL4
14
Show member pathways
11.23 FOXP3 IL10 TNF
15 11.15 IL10 TLR9 TNF
16 11.15 CD40LG IL10 TLR9 TNF
17 11.06 CD40LG IL10 IL4 TNF
18 11.02 IL10 IL4 TNF
19 10.95 CD40LG FOXP3 IL10 IL4 TLR9 TNF
20 10.29 TG TSHR

GO Terms for Hypersensitivity Reaction Disease

Cellular components related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 APOH CD40LG IL10 IL4 PRTN3 TLR9
2 extracellular region GO:0005576 9.65 APOH CD40LG COL17A1 IL10 IL4 PRTN3
3 external side of plasma membrane GO:0009897 9.02 CD40LG CD79A IL4 TNF TRPV1

Biological processes related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.76 FOXP3 TLR9 TRIM21
2 inflammatory response GO:0006954 9.7 CD40LG IL10 MEFV TLR9 TNF TNFRSF25
3 response to molecule of bacterial origin GO:0002237 9.62 IL10 TLR9
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.62 IL10 IL4 TNF TRIM21
5 negative regulation of interleukin-12 production GO:0032695 9.61 IL10 MEFV
6 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
7 positive regulation of chemokine biosynthetic process GO:0045080 9.59 IL4 TNF
8 B cell proliferation GO:0042100 9.58 CD40LG CD79A IL10
9 endothelial cell apoptotic process GO:0072577 9.57 IL10 TNF
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IL10 IL4
11 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 IL10 TNF
12 type 2 immune response GO:0042092 9.54 IL10 IL4
13 negative regulation of interleukin-8 production GO:0032717 9.52 IL10 TLR9
14 regulation of immunoglobulin secretion GO:0051023 9.51 CD40LG TNF
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.49 FOXP3 IL4
16 regulation of isotype switching GO:0045191 9.48 IL10 IL4
17 negative regulation of chronic inflammatory response GO:0002677 9.46 FOXP3 IL4
18 positive regulation of mononuclear cell migration GO:0071677 9.43 IL4 TNF
19 positive regulation of interleukin-10 production GO:0032733 9.43 CD40LG IL4 TLR9
20 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
21 positive regulation of immunoglobulin production GO:0002639 9.27 IL4
22 negative regulation of interleukin-6 production GO:0032715 9.26 FOXP3 IL10 TLR9 TNF
23 B cell differentiation GO:0030183 9.02 CD40LG CD79A IL10 IL4 TSHR
24 immune response GO:0006955 10 CD40LG IL10 IL4 TNF TNFRSF25

Molecular functions related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 APOH SCHIP1 TNF TRIM21 TRPV1
2 cytokine activity GO:0005125 8.92 CD40LG IL10 IL4 TNF

Sources for Hypersensitivity Reaction Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....