MCID: HYP071
MIFTS: 37

Hypersensitivity Reaction Type Ii Disease malady

Immune diseases category
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Summaries for Hypersensitivity Reaction Type Ii Disease

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8Disease Ontology, 34MedlinePlus, 33MalaCards
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MedlinePlus:34 Your body's immune system protects you from disease and infection. but if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. autoimmune diseases can affect many parts of the body. no one is sure what causes autoimmune diseases. they do tend to run in families. women - particularly african-american, hispanic-american, and native-american women - have a higher risk for some autoimmune diseases. there are more than 80 types of autoimmune diseases, and some have similar symptoms. this makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. getting a diagnosis can be frustrating and stressful. often, the first symptoms are fatigue, muscle aches and a low fever. the classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. the diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. treatment depends on the disease, but in most cases one important goal is to reduce inflammation. sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards: Hypersensitivity Reaction Type Ii Disease, also known as autoimmune diseases, is related to rheumatoid arthritis and myasthenia gravis. An important gene associated with Hypersensitivity Reaction Type Ii Disease is TRAC (T cell receptor alpha constant), and among its related pathways are Translocation of ZAP-70 to Immunological synapse and TCR signaling. The drugs prednisone and prednisone pwdr and the compound ricin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:8 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or t cell directed against the host tissues.

Aliases & Classifications for Hypersensitivity Reaction Type Ii Disease

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

hypersensitivity reaction type ii disease 8 10
autoimmune diseases 45 34 62
hypersensitivity reaction mediated by antibody 62
autoimmune disease 8


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Disease Ontology8 DOID:417
MeSH35 D001327
ICD9CM27 720

Related Diseases for Hypersensitivity Reaction Type Ii Disease

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17GeneCards, 18GeneDecks
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Diseases in the Hypersensitivity Reaction Type Ii Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Type Ii Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis30.5HLA-DQB3, HLA-DRB4, MOG, CD5, CD19
2myasthenia gravis30.4MOG, AIRE
3autoimmune thyroiditis30.1HLA-DRB4, AIRE
4leukemia30.0LYZ, CD5, CD19, TRAC
5thymoma29.9CD5, AIRE
6skin disease29.7LYZ, PRF1
7arthritis10.5
8lupus erythematosus10.5
9systemic lupus erythematosus10.4
10multiple sclerosis10.4
11thyroiditis10.4
12pemphigus10.3
13diabetes mellitus10.3
14hepatitis10.3
15primary biliary cirrhosis10.3
16antiphospholipid syndrome10.2
17autoimmune disease of cardiovascular system10.2
18autoimmune disease of eyes, ear, nose and throat10.2
19goodpasture syndrome10.2
20sjogren's syndrome10.2
21vogt-koyanagi-harada disease10.2
22vitiligo10.2
23alopecia areata10.2
24autoimmune disease of blood10.2
25autoimmune disease of endocrine system10.2
26autoimmune disease of gastrointestinal tract10.2
27autoimmune disease of skin and connective tissue10.2
28autoimmune disease of urogenital tract10.2
29celiac disease10.2
30vitiligo-associated multiple autoimmune disease susceptibility 110.2
31hepatitis c10.2
32autoimmune hepatitis10.2
33addison's disease10.2
34graves' disease10.2
35vasculitis10.2
36itch e3 ubiquitin ligase deficiency10.2
37malt lymphoma10.2
38bullous pemphigoid10.1
39wegener's granulomatosis10.1
40stiff-person syndrome10.1
41alopecia10.1
42atherosclerosis10.1
43lymphopenia10.1
44scleroderma10.1
45uveitis10.1
46endotheliitis10.1
47mixed connective tissue disease10.1
48alopecia universalis10.1
49connective tissue disease10.1
50dermatomyositis10.1

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Ii Disease:



Diseases related to hypersensitivity reaction type ii disease

Symptoms for Hypersensitivity Reaction Type Ii Disease

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Drugs & Therapeutics for Hypersensitivity Reaction Type Ii Disease

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hypersensitivity Reaction Type Ii Disease

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Anatomical Context for Hypersensitivity Reaction Type Ii Disease

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33MalaCards
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MalaCards organs/tissues related to Hypersensitivity Reaction Type Ii Disease:

33
T cells

Animal Models for Hypersensitivity Reaction Type Ii Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Ii Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2CD19, TBX21, PRF1, AIRE
2MP:00053847.9AIRE, PRF1, MOG, TBX21, CD19
3MP:00053977.3MOG, TBX21, CD5, CD19, AIRE, PRF1
4MP:00053877.2PRF1, MOG, TBX21, CD5, CD19, AIRE

Publications for Hypersensitivity Reaction Type Ii Disease

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Variations for Hypersensitivity Reaction Type Ii Disease

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Expression for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersensitivity Reaction Type Ii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Ii Disease.

Pathways for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 53QIAGEN, 38NCBI BioSystems Database
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Compounds for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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45Novoseek
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Compounds related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ricin459.6CD19, CD5

GO Terms for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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16Gene Ontology
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Cellular components related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CD19, CD5, HLA-DRB4
2plasma membraneGO:0058867.5TRAC, CD19, CD5, MOG, PRF1, HLA-DRB4

Biological processes related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.8TRAC, CD19
2T cell receptor signaling pathwayGO:0508529.6TRAC, HLA-DRB4
3T cell costimulationGO:0312959.4CD5, HLA-DRB4, TRAC
4cytolysisGO:0198359.2LYZ, PRF1
5cellular defense responseGO:0069689.2CD19, PRF1

Products for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypersensitivity Reaction Type Ii Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet