MCID: HYP071
MIFTS: 37

Hypersensitivity Reaction Type Ii Disease malady

Immune diseases category
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Summaries for Hypersensitivity Reaction Type Ii Disease

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MedlinePlus:33 Your body's immune system protects you from disease and infection. but if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. autoimmune diseases can affect many parts of the body. no one is sure what causes autoimmune diseases. they do tend to run in families. women - particularly african-american, hispanic-american, and native-american women - have a higher risk for some autoimmune diseases. there are more than 80 types of autoimmune diseases, and some have similar symptoms. this makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. getting a diagnosis can be frustrating and stressful. often, the first symptoms are fatigue, muscle aches and a low fever. the classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. the diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. treatment depends on the disease, but in most cases one important goal is to reduce inflammation. sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards based summary: Hypersensitivity Reaction Type Ii Disease, also known as autoimmune diseases, is related to myasthenia gravis and autoimmune thyroiditis, and has symptoms including An important gene associated with Hypersensitivity Reaction Type Ii Disease is TRAC (T cell receptor alpha constant), and among its related pathways are Translocation of ZAP-70 to Immunological synapse and TCR signaling. The drugs prednisone and prednisone pwdr and the compound ricin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:8 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or t cell directed against the host tissues.

Aliases & Classifications for Hypersensitivity Reaction Type Ii Disease

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Hypersensitivity Reaction Type Ii Disease, Aliases & Descriptions:

Name: Hypersensitivity Reaction Type Ii Disease 8 10
Autoimmune Diseases 44 33 62
 
Hypersensitivity Reaction Mediated by Antibody 62
Autoimmune Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:417
ICD9CM27 720
MeSH34 D001327

Related Diseases for Hypersensitivity Reaction Type Ii Disease

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Diseases in the Hypersensitivity Reaction Type Ii Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Type Ii Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 310)
idRelated DiseaseScoreTop Affiliating Genes
1myasthenia gravis30.3MOG, AIRE
2autoimmune thyroiditis30.2AIRE, HLA-DRB4
3rheumatoid arthritis29.9MOG, HLA-DRB4, HLA-DQB3, CD19, CD5
4thymoma29.9CD5, AIRE
5skin disease29.8LYZ, PRF1
6leukemia29.5CD19, CD5, TRAC, LYZ
7arthritis10.5
8systemic lupus erythematosus10.5
9lupus erythematosus10.5
10multiple sclerosis10.4
11thyroiditis10.4
12pemphigus10.3
13diabetes mellitus10.3
14hepatitis10.3
15primary biliary cirrhosis10.3
16vitiligo-associated multiple autoimmune disease susceptibility 110.3
17vitiligo10.3
18antiphospholipid syndrome10.3
19goodpasture syndrome10.3
20sjogren's syndrome10.3
21vogt-koyanagi-harada disease10.3
22autoimmune disease of cardiovascular system10.3
23autoimmune disease of eyes, ear, nose and throat10.3
24alopecia areata10.3
25autoimmune disease of blood10.3
26autoimmune disease of endocrine system10.3
27autoimmune disease of gastrointestinal tract10.3
28autoimmune disease of skin and connective tissue10.3
29autoimmune disease of urogenital tract10.3
30celiac disease10.2
31graves' disease10.2
32endotheliitis10.2
33autoimmune hepatitis10.2
34malt lymphoma10.2
35hepatitis c10.2
36addison's disease10.2
37bullous pemphigoid10.2
38vasculitis10.2
39alopecia10.1
40atherosclerosis10.1
41stiff-person syndrome10.1
42wegener's granulomatosis10.1
43dermatomyositis10.1
44lymphopenia10.1
45scleroderma10.1
46macroglobulinemia10.1CD19, CD5
47mixed connective tissue disease10.1
48autoimmune disease of the nervous system10.1
49connective tissue disease10.1
50pneumonia10.1

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Ii Disease:



Diseases related to hypersensitivity reaction type ii disease

Symptoms for Hypersensitivity Reaction Type Ii Disease

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HPO human phenotypes related to Hypersensitivity Reaction Type Ii Disease:

id Description Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis HP:0001939
2 autoimmunity HP:0002960

Drugs & Therapeutics for Hypersensitivity Reaction Type Ii Disease

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Drug clinical trials:

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Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Hypersensitivity Reaction Type Ii Disease

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Anatomical Context for Hypersensitivity Reaction Type Ii Disease

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MalaCards organs/tissues related to Hypersensitivity Reaction Type Ii Disease:

32
T cells

Animal Models for Hypersensitivity Reaction Type Ii Disease or affiliated genes

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MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Ii Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2AIRE, PRF1, TBX21, CD19
2MP:00053847.9CD19, TBX21, MOG, PRF1, AIRE
3MP:00053977.3CD19, CD5, TBX21, MOG, PRF1, AIRE
4MP:00053877.2AIRE, PRF1, MOG, TBX21, CD5, CD19

Publications for Hypersensitivity Reaction Type Ii Disease

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Variations for Hypersensitivity Reaction Type Ii Disease

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Expression for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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Expression patterns in normal tissues for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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Pathways for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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Compounds for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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Sources:
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Compounds related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ricin449.6CD19, CD5

GO Terms for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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Cellular components related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CD19, CD5, HLA-DRB4
2plasma membraneGO:0058867.5TRAC, CD19, CD5, MOG, PRF1, HLA-DRB4

Biological processes related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.8TRAC, CD19
2T cell receptor signaling pathwayGO:0508529.6TRAC, HLA-DRB4
3T cell costimulationGO:0312959.4TRAC, CD5, HLA-DRB4
4cytolysisGO:0198359.2LYZ, PRF1
5cellular defense responseGO:0069689.2PRF1, CD19

Products for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hypersensitivity Reaction Type Ii Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet