MCID: HYP071
MIFTS: 43

Hypersensitivity Reaction Type Ii Disease malady

Immune diseases category

Summaries for Hypersensitivity Reaction Type Ii Disease

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8Disease Ontology, 33MedlinePlus, 32MalaCards
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MedlinePlus:33 Your body's immune system protects you from disease and infection. but if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. autoimmune diseases can affect many parts of the body. no one is sure what causes autoimmune diseases. they do tend to run in families. women - particularly african-american, hispanic-american, and native-american women - have a higher risk for some autoimmune diseases. there are more than 80 types of autoimmune diseases, and some have similar symptoms. this makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. getting a diagnosis can be frustrating and stressful. often, the first symptoms are fatigue, muscle aches and a low fever. the classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. the diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. treatment depends on the disease, but in most cases one important goal is to reduce inflammation. sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards: Hypersensitivity Reaction Type Ii Disease, also known as autoimmune diseases, is related to arthritis and rheumatoid arthritis. An important gene associated with Hypersensitivity Reaction Type Ii Disease is TRAC (T cell receptor alpha constant), and among its related pathways are PEDF Induced Signaling and Classical antibody-mediated complement activation. The drugs prednisone and prednisone pwdr and the compounds latex and nacl have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or t cell directed against the host tissues.

Aliases & Classifications for Hypersensitivity Reaction Type Ii Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

hypersensitivity reaction type ii disease 8 10
autoimmune diseases 44 33 60
hypersensitivity reaction mediated by antibody 60
autoimmune disease 8


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Disease Ontology8 DOID:417
ICD9CM27 720
MeSH34 D001327

Related Diseases for Hypersensitivity Reaction Type Ii Disease

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17GeneCards, 18GeneDecks
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Diseases in the Hypersensitivity Reaction Type Ii Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Type Ii Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.7LYZ, ALPPL2, FCGR1A, FTH1, MRAP, CTSG
2rheumatoid arthritis30.7CTSG, HLA-DQB3, CD68, CD19, CXCR5, FCGR1A
3systemic lupus erythematosus30.7TNFRSF17, CTSG, CD2, CXCR5, FCGR1A
4multiple sclerosis30.7CXCR5, CD2, TNFRSF13B, TBX21, TNFRSF17
5diabetes mellitus30.5ALPPL2, AIRE, FTH1, HLA-DQB3
6hepatitis30.5AIRE
7addison's disease30.3NUDT10, AIRE
8skin disease30.3ALPPL2, CD68, PRF1, LYZ
9leukemia30.2ALPPL2, CTSG, TRAC, CD19, CD2, CXCR5
10thrombocytopenia30.1ALPPL2, CD19
11common variable immune deficiency30.1TNFRSF13B
12cholangitis30.1ALPPL2
13chronic lymphocytic leukemia29.9CD19, TNFRSF13B, TNFRSF17, CXCR5
14pernicious anemia29.9GIF
15non-hodgkin lymphoma29.7CXCR5, TNFRSF13B, TNFRSF17, CD19
16arthropathy29.7MRAP
17autoimmune lymphoproliferative syndrome29.7TRAC
18lupus erythematosus10.5
19autoimmune thyroiditis10.5
20thyroiditis10.5
21pemphigus10.4
22autoimmune hepatitis10.4
23vitiligo10.3
24autoimmune disease of blood10.3
25primary biliary cirrhosis10.3
26myasthenia gravis10.3
27celiac disease10.2
28autoimmune disease of central nervous system10.2
29graves' disease10.2
30autoimmune disease of the nervous system10.2
31central nervous system disease10.2
32nervous system disease10.2
33vitiligo-associated multiple autoimmune disease susceptibility 110.2
34bullous pemphigoid10.2
35hepatitis c10.2
36sjogren's syndrome10.2
37vasculitis10.2
38wegener's granulomatosis10.2
39stiff-person syndrome10.2
40alopecia10.2
41atherosclerosis10.2
42collagen disease10.2
43lichen disease10.2
44liver disease10.2
45lymphopenia10.2
46scleroderma10.2
47uveitis10.2
48itch e3 ubiquitin ligase deficiency10.2
49mixed connective tissue disease10.1
50alopecia universalis10.1

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Ii Disease:



Diseases related to hypersensitivity reaction type ii disease

Clinical Features for Hypersensitivity Reaction Type Ii Disease

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Drugs & Therapeutics for Hypersensitivity Reaction Type Ii Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Hypersensitivity Reaction Type Ii Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypersensitivity Reaction Type Ii Disease

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Anatomical Context for Hypersensitivity Reaction Type Ii Disease

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32MalaCards
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MalaCards organs/tissues related to Hypersensitivity Reaction Type Ii Disease:

32
T cells

Animal Models for Hypersensitivity Reaction Type Ii Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Ii Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0FCGR1A, TNFRSF25, TNFRSF13B, TNFRSF17, CTSG, PRF1
2MP:000539710.9PRF1, CTSG, TNFRSF17, TNFRSF13B, TNFRSF25, TBX21
3MP:000538410.8TNFRSF13B, PRF1, TBX21, AIRE, FTH1, CD19
4MP:000200610.6TNFRSF13B, CTSG, TBX21, AIRE, CD19
5MP:000537010.6TNFRSF13B, CTSG, PRF1, AIRE, FTH1, CD19
6MP:000287310.4TNFRSF17, CTSG, PRF1, AIRE, CD19, CD2

Publications for Hypersensitivity Reaction Type Ii Disease

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Genetic Variations for Hypersensitivity Reaction Type Ii Disease

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Expression for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersensitivity Reaction Type Ii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Ii Disease.

Pathways for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore, 55SinoBiological, 52R&D Systems
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Compounds for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1latex4410.8FCGR1A, CD2, CD68, FTH1
2nacl4410.7CTSG, PRF1, FTH1, LYZ
3hemolysins4410.7CTSG, PRF1
4baff2810.7TNFRSF17, TNFRSF13B
5lipid4410.7FTH1, CD68, CD19, CD2, FCGR1A, CTSG
6bcma4410.6TNFRSF17, TNFRSF13B
7alefacept44 1111.5FCGR1A, CD2
8blys4410.4TNFRSF13B, TNFRSF17
9calcium44 49 11 2413.4TNFRSF13B, TNFRSF17, CTSG, PRF1, CD19, CD2

GO Terms for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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16Gene Ontology
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Cellular components related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7TNFRSF13B, TRAC, CD19, CD2, CXCR5, TNFRSF25
2plasma membraneGO:00588610.6ALPPL2, MRAP, TNFRSF25, TNFRSF17, CTSG, PRF1

Biological processes related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.6FCGR1A, CXCR5, FTH1, AIRE, CTSG
2cytolysisGO:01983510.5LYZ, PRF1
3cell surface receptor signaling pathwayGO:00716610.5TNFRSF25, TNFRSF13B, CD19, CD2
4cellular defense responseGO:00696810.3CD19, TRAC, PRF1

Molecular functions related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:00503110.5TNFRSF17, TNFRSF25
2receptor activityGO:00487210.3CD2, TNFRSF17, TNFRSF13B, TNFRSF25

Products for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypersensitivity Reaction Type Ii Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet