MCID: HYP071
MIFTS: 41

Hypersensitivity Reaction Type Ii Disease malady

Summaries for Hypersensitivity Reaction Type Ii Disease

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8Disease Ontology, 34MedlinePlus, 33MalaCards
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MedlinePlus:34 Your body's immune system protects you from disease and infection. but if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. autoimmune diseases can affect many parts of the body. no one is sure what causes autoimmune diseases. they do tend to run in families. women - particularly african-american, hispanic-american, and native-american women - have a higher risk for some autoimmune diseases. there are more than 80 types of autoimmune diseases, and some have similar symptoms. this makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. getting a diagnosis can be frustrating and stressful. often, the first symptoms are fatigue, muscle aches and a low fever. the classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. the diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. treatment depends on the disease, but in most cases one important goal is to reduce inflammation. sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards: Hypersensitivity Reaction Type Ii Disease, also known as autoimmune diseases, is related to arthritis and systemic lupus erythematosus. An important gene associated with Hypersensitivity Reaction Type Ii Disease is TRAC (T cell receptor alpha constant), and among its related pathways are PEDF Induced Signaling and Classical antibody-mediated complement activation. The drugs prednisone and prednisone pwdr and the compounds latex and nacl have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or t cell directed against the host tissues.

Aliases & Classifications for Hypersensitivity Reaction Type Ii Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

hypersensitivity reaction type ii disease 8 10
autoimmune diseases 45 34 61
hypersensitivity reaction mediated by antibody 61
autoimmune disease 8


External Ids:

Disease Ontology8 DOID:417
ICD9CM27 720
MeSH35 D001327

Related Diseases for Hypersensitivity Reaction Type Ii Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hypersensitivity Reaction Type Ii Disease family:

hypersensitivity reaction type iii disease hypersensitivity reaction type iv disease

Diseases related to Hypersensitivity Reaction Type Ii Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.8LYZ, ALPPL2, FCGR1A, FTH1, MRAP, CTSG
2systemic lupus erythematosus30.7TNFRSF17, CTSG, CD2, CXCR5, FCGR1A
3addison's disease30.3NUDT10, AIRE
4thrombocytopenia30.1ALPPL2, CD19
5common variable immune deficiency30.1TNFRSF13B
6primary sclerosing cholangitis30.1CTSG, AIRE
7pernicious anemia30.0GIF
8leukopenia29.8CD19, ALPPL2
9arthropathy29.8MRAP
10autoimmune lymphoproliferative syndrome29.7TRAC
11pemphigus10.4
12autoimmune hepatitis10.4
13vitiligo10.4
14primary biliary cirrhosis10.3
15hepatitis d10.3
16hepatitis a10.3
17autoimmune disease 110.3
18hepatitis c10.3
19lip disease10.3
20celiac disease10.3
21graves' disease10.3
22vitiligo-associated multiple autoimmune disease susceptibility 110.3
23bullous pemphigoid10.2
24sjogren's syndrome10.2
25vasculitis10.2
26autoimmune thyroiditis10.2
27stiff-person syndrome10.2
28alopecia10.2
29atherosclerosis10.2
30uveitis10.2
31itch e3 ubiquitin ligase deficiency10.2
32mixed connective tissue disease10.2
33alopecia universalis10.2
34alopecia areata10.2
35thyroiditis10.2
36cogan's syndrome10.2
37autoimmune disease 610.2
38graft versus host disease10.1
39autoimmune disease of musculoskeletal system10.1
40antiphospholipid syndrome10.1
41hyperprolactinemia10.1
42autoimmune disease of eyes, ear, nose and throat10.1
43gastric lymphoma10.1
44lichen planus10.1
45juvenile rheumatoid arthritis10.1
46autoimmune disease of central nervous system10.1
47silicosis10.1
48hepatitis b10.1
49sclerosing cholangitis10.1
50aplastic anemia10.1

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Ii Disease:



Diseases related to hypersensitivity reaction type ii disease

Clinical Features for Hypersensitivity Reaction Type Ii Disease

Drugs & Therapeutics for Hypersensitivity Reaction Type Ii Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hypersensitivity Reaction Type Ii Disease

Anatomical Context for Hypersensitivity Reaction Type Ii Disease

Animal Models for Hypersensitivity Reaction Type Ii Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Ii Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0FCGR1A, TNFRSF25, TNFRSF13B, TNFRSF17, CTSG, PRF1
2MP:000539710.9PRF1, CTSG, TNFRSF17, TNFRSF13B, TNFRSF25, TBX21
3MP:000538410.8TNFRSF13B, PRF1, TBX21, AIRE, FTH1, CD19
4MP:000200610.6TNFRSF13B, CTSG, TBX21, AIRE, CD19
5MP:000537010.6TNFRSF13B, CTSG, PRF1, AIRE, FTH1, CD19
6MP:000287310.4TNFRSF17, CTSG, PRF1, AIRE, CD19, CD2

Publications for Hypersensitivity Reaction Type Ii Disease

Genetic Variations for Hypersensitivity Reaction Type Ii Disease

Expression for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersensitivity Reaction Type Ii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Ii Disease.

Pathways for genes affiliated with Hypersensitivity Reaction Type Ii Disease

Sources:
52QIAGEN, 30KEGG, 54Reactome, 12EMD Millipore, 56SinoBiological, 53R&D Systems
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Compounds for genes affiliated with Hypersensitivity Reaction Type Ii Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1latex4510.8FCGR1A, CD2, CD68, FTH1
2nacl4510.7CTSG, PRF1, FTH1, LYZ
3hemolysins4510.7CTSG, PRF1
4baff2910.7TNFRSF17, TNFRSF13B
5lipid4510.7FTH1, CD68, CD19, CD2, FCGR1A, CTSG
6bcma4510.6TNFRSF17, TNFRSF13B
7alefacept45 1111.5FCGR1A, CD2
8blys4510.4TNFRSF13B, TNFRSF17
9calcium45 50 11 2413.4TNFRSF13B, TNFRSF17, CTSG, PRF1, CD19, CD2

GO Terms for genes affiliated with Hypersensitivity Reaction Type Ii Disease

Sources:
16Gene Ontology
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Cellular components related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7TNFRSF13B, TRAC, CD19, CD2, CXCR5, TNFRSF25
2plasma membraneGO:00588610.6ALPPL2, MRAP, TNFRSF25, TNFRSF17, CTSG, PRF1

Biological processes related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.6FCGR1A, CXCR5, FTH1, AIRE, CTSG
2cytolysisGO:01983510.5LYZ, PRF1
3cell surface receptor signaling pathwayGO:00716610.5TNFRSF25, TNFRSF13B, CD19, CD2
4cellular defense responseGO:00696810.3CD19, TRAC, PRF1

Molecular functions related to Hypersensitivity Reaction Type Ii Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:00503110.5TNFRSF17, TNFRSF25
2receptor activityGO:00487210.3CD2, TNFRSF17, TNFRSF13B, TNFRSF25

Products for genes affiliated with Hypersensitivity Reaction Type Ii Disease

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Sources for Hypersensitivity Reaction Type Ii Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet