Hypersensitivity Reaction Type Ii Disease malady

MedlinePlus: Your body's immune system protects you from disease and infection. but if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. autoimmune diseases can affect many parts of the body. these diseases tend to run in families. women - particularly african-american, hispanic-american, and native-american women - have a higher risk for some autoimmune diseases. there are more than 80 types of autoimmune diseases, and some have similar symptoms. this makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. getting diagnosed can be frustrating and stressful. in many people, the first symptoms are being tired, muscle aches and low fever. the diseases may also have flare-ups, when they get worse, and remissions, when they all but disappear. the diseases do not usually go away, but symptoms can be treated.²³

MalaCards: Hypersensitivity Reaction Type Ii Disease, also known as autoimmune diseases, is related to rheumatoid arthritis and multiple sclerosis. An important gene associated with Hypersensitivity Reaction Type Ii Disease is TRAC (T cell receptor alpha constant), and among its related pathways are Cell adhesion molecules (CAMs) and Lymphocyte Signaling. The drugs prednisone and prednisone pwdr [va product] and the compounds glucose and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or t cell directed against the host tissues.⁶

Aliases & Descriptions:

hypersensitivity reaction type ii disease 6 8 autoimmune diseases 17 32 23 43

hypersensitivity reaction mediated by antibody 43 autoimmune disease 6

Disease types for hypersensitivity reaction type ii disease family:

hypersensitivity reaction type iii disease	hypersensitivity reaction type iv disease

Diseases related to hypersensitivity reaction type ii disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1021)

id	Related Disease	Score	Top Affiliating Genes
1	rheumatoid arthritis	32.8	IL1RN, HLA-DRB1, TNFRSF1A, CRP, LTA, PRTN3
2	multiple sclerosis	31.1	MOG, CD40, IL1A, IL1B, IL1RN, IL2RA
3	arthritis	31.0	SELL, SERPINA1, IL17A, IL1A, IL1B, IL6
4	bullous pemphigoid	30.3	CD79A, ITGAL, IL13, IL5, IL7, CCL5
5	primary biliary cirrhosis	29.4	SELL, VDR, BGLAP, CD79A, CD40LG, ITGAL
6	celiac disease	28.8	MIF, IL6, HLA-DQB1, HLA-DRB1, TNF, CTLA4
7	addison's disease	28.6	VDR, BGLAP, MRAP, CD79A, FOXP3, INS
8	autoimmune polyendocrine syndrome	28.6	INS, IL17A, AIRE, TPO, TG, GAD2
9	hepatitis	28.5	SELP, SERPINA1, GZMB, FASLG, FAS, IFNA1
10	vogt-koyanagi-harada disease	28.4	CD8A, MIF, IL17A, IL2RA, FASLG, FAS
11	cold agglutinin disease	28.2	MS4A1, IL6, TNF, CRP
12	primary sclerosing cholangitis	28.1	MPO, AIRE, HLA-A, HLA-C, CTSG, LTF
13	reactive arthritis	27.8	CD79A, HSPD1, HLA-B, TRH, CRP, LTF
14	venous thrombosis	27.7	VWF, SELP, ITGAM, F8, HLA-B, CTSG
15	acute promyelocytic leukemia	27.6	NCAM1, BCL2, MPO, ITGAL, PTPN3, PTPRC
16	autoimmune thyroiditis	27.6	CD80, CD40, ITGAL, IL2RA, IL4, FASLG
17	selective iga deficiency disease	27.5	CD79A, CD40LG, IL10, IL4, LTA
18	heparin-induced thrombocytopenia	27.3	SELE, SELP, CD79A, CD40LG, ALB
19	gamma chain deficiency	27.2	IL13, IL2, IL21, IL2RA, IL4, IL7
20	leprosy	27.1	VDR, IL10, HLA-DQB1, HLA-DRB1, LTA, TLR2
21	myeloproliferative disorder	27.1	VWF, SELP, BCR, MPO, IFNA1, PTPN11
22	dermatitis herpetiformis	26.9	SELE, CD79A, CD40LG, ITGAM, IL13, IL2RA
23	antiphospholipid syndrome	26.9	VWF, SELE, SELP, VCAM1, CD79A, CD40LG
24	hypoparathyroidism	26.9	VDR, BGLAP, INS, IL2RA, ALPP, AIRE
25	collagen disease	26.8	VWF, IL10, IL2RA, IL6, IFNG, TNF
26	vitiligo	26.7	VDR, MPO, CD79A, CD8A, CD4, FOXP3
27	interstitial lung disease	26.3	ITGAM, IL1A, IL1RN, IL8, CCL2, CCL5
28	pemphigus foliaceus	26.1	CD79A, CD40LG, CD19, CD40, IL10, IL1A
29	malaria	26.1	CD40LG, IL10, IL1A, IL4, IFNG, TNF
30	wilson disease	25.9	SERPINA1, B2M, CD79A, IL1A, IL1B, IL1RN
31	guillain-barre syndrome	25.9	MOG, CD79A, CD40LG, CD1D, IL10, FAS
32	asthma	25.8	MPO, IL13, IL1B, IL4, CCL2, CCR5
33	juvenile rheumatoid arthritis	25.7	BGLAP, IL1A, IL1RN, IL2RA, IL6, HSPD1
34	optic neuritis	25.7	SAG, MOG, CD86, CD40LG, CD80, IL10
35	localized scleroderma	25.7	CD40LG, IL13, IL2RA, IL4, IL8, CCL5
36	pulmonary alveolar proteinosis	25.6	VDR, IL10, IL1B, IL5, IL8, CCL2
37	type 1 diabetes mellitus	25.5	VDR, BGLAP, B2M, CD79A, CD69, INS
38	thymoma	25.5	BCL2, LCK, B2M, MS4A1, MPO, CD2
39	turner syndrome	25.5	VDR, BGLAP, CD79A, CD40LG, FOXP3, INS
40	mixed connective tissue disease	25.2	CD40LG, INS, IL6, HSPG2, HSPD1, HLA-A
41	hepatitis c	24.7	SERPINA1, CD28, CD69, CD40LG, IL10, IL18
42	autoimmune hemolytic anemia	24.6	VWF, MPO, CD79A, CD40LG, IL10, IL17A
43	microscopic polyangiitis	24.5	SELE, MPO, IL10, IL2RA, HLA-B, HLA-DQB1
44	crohn's disease	24.5	MPO, CD80, FOXP3, MIF, IL10, IL13
45	systemic lupus erythematosus	24.4	VWF, SELE, VCAM1, BCR, LCK, MPO
46	paralysis	24.4	MOG, MIF, INS, IL10, IL1B, MBP
47	systemic scleroderma	24.2	VWF, SELE, SELL, VCAM1, CD28, CD86
48	graft versus host disease	24.2	SELL, CD28, ITGAL, GZMB, IL10, IL13
49	cicatricial pemphigoid	24.1	CD79A, MIF, IL1A, IL1B, IL1RN, IL4
50	wegener's granulomatosis	24.1	VWF, SELE, SERPINA1, VCAM1, MPO, CD28

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to hypersensitivity reaction type ii disease:

²²

MGI Mouse Phenotypes related to hypersensitivity reaction type ii disease:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	SELL, SELP, CD1D, ALPL, PTPN22, PTPRC
2	craniofacial phenotype	MP:0005382	10.2	CSF2, PTPN11, HSPG2, ALPL, IL17A, FOXP3
3	renal/urinary system phenotype	MP:0005367	9.9	SOD2, PLG, PTPRC, TNFRSF1B, TNFRSF13B, INS
4	hematopoietic system phenotype	MP:0005397	9.7	ALPL, ADAMTS13, C5AR1, HLA-C, HLA-DQB1, TNFRSF13B
5	endocrine/exocrine gland phenotype	MP:0005379	9.5	SELL, CD40LG, IL2, FASLG, IFNG, AIRE
6	no phenotypic analysis	MP:0003012	9.5	CCR5, ICOS, AIRE, HLA-C, PTPN3, PTPN11
7	other phenotype	MP:0005395	9.0	CSF2, SOD2, CXCR3, TLR2, TNFRSF1A, HSPG2
8	liver/biliary system phenotype	MP:0005370	9.0	PTPRC, CTLA4, CTSG, PLG, TLR2, TLR4
9	skeleton phenotype	MP:0005390	8.9	TNFRSF1B, PTPN3, PTPN11, PTPRC, CYCS, CTLA4
10	digestive/alimentary phenotype	MP:0005381	8.7	VWF, VDR, BCL2, BCR, PLG, TLR2
11	integument phenotype	MP:0010771	8.6	IFNG, TNFRSF1A, TNFRSF1B, PTPN11, CTLA4, TLR2
12	nervous system phenotype	MP:0003631	8.4	CD86, CD8A, CD4, CD1D, CD80, CD19
13	adipose tissue phenotype	MP:0005375	8.0	WDTC1, TLR2, TLR4, TGFB1, SOD2, CSF2
14	normal phenotype	MP:0002873	7.3	PTPN3, TNFRSF17, HLA-DQB1, AIRE, ALPP, ALB
15	growth/size phenotype	MP:0005378	7.2	HSPG2, GGT1, GAD2, CSF2, TG, HSPD1
16	mortality/aging	MP:0010768	7.1	WDTC1, KLRK1, TSHR, TLR2, TLR4, PRF1
17	immune system phenotype	MP:0005387	6.8	VWF, MIF, FCGR1A, IL2, IL23A, IL6
18	muscle phenotype	MP:0005369	6.5	HLA-DQB1, TNF, TNFRSF1A, TNFRSF1B, PTPN11, PLAT
19	reproductive system phenotype	MP:0005389	6.2	VDR, B2M, CD44, TLR4, TGFB1, SOD2
20	behavior/neurological phenotype	MP:0005386	5.8	CYCS, TNFRSF1B, TNFRSF1A, HLA-DQB1, HLA-C, AIRE
21	tumorigenesis	MP:0002006	5.6	IL5, IL6, FASLG, FAS, CCL2, CCR5
22	vision/eye phenotype	MP:0005391	5.4	TNFRSF1A, TNF, AIRE, HSPG2, ICAM1, IFNG
23	homeostasis/metabolism phenotype	MP:0005376	4.9	ALB, WDTC1, TSHR, TLR2, TLR4, TG
24	cardiovascular system phenotype	MP:0005385	3.6	VWF, SELE, SELL, SELP, VDR, VCAM1
25	cellular phenotype	MP:0005384	3.1	VWF, SELE, SELL, SELP, VDR, VCAM1

Genes related to hypersensitivity reaction type ii disease according to GeneCards:

(show top 50)    (show all 147)

id	Symbol	Description	Score	GeneCards Section Context
1	TRAC	T cell receptor alpha constant	11.0
2	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
3	NUDT10	nudix (nucleoside diphosphate linked moiety X)-type motif 10	11.0
4	MRAP	melanocortin 2 receptor accessory protein	11.0
5	GIF	gastric intrinsic factor (vitamin B synthesis)	11.0
6	TBX21	T-box 21	11.0
7	RBP3	retinol binding protein 3, interstitial	11.0
8	CD68	CD68 molecule	11.0
9	WDTC1	WD and tetratricopeptide repeats 1	11.0
10	TNFRSF17	tumor necrosis factor receptor superfamily, member 17	11.0
11	TNFRSF18	tumor necrosis factor receptor superfamily, member 18	11.0
12	ALPPL2	alkaline phosphatase, placental-like 2	11.0
13	THY1	Thy-1 cell surface antigen	11.0
14	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	11.0
15	CD276	CD276 molecule	11.0
16	IL23A	interleukin 23, alpha subunit p19	11.0
17	AIRE	autoimmune regulator	11.0
18	CXCR5	chemokine (C-X-C motif) receptor 5	11.0
19	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0
20	FTH1	ferritin, heavy polypeptide 1	11.0
21	FTL	ferritin, light polypeptide	11.0
22	MOG	myelin oligodendrocyte glycoprotein	11.0
23	WDR11	WD repeat domain 11	11.0
24	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	11.0
25	CD8A	CD8a molecule	11.0
26	CD5	CD5 molecule	11.0
27	ICOS	inducible T-cell co-stimulator	11.0
28	TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	11.0
29	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	11.0
30	CD19	CD19 molecule	11.0
31	CD1D	CD1d molecule	11.0
32	CD2	CD2 molecule	11.0
33	TH1L	TH1-like (Drosophila)	11.0
34	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	11.0
35	IL17A	interleukin 17A	11.0
36	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0
37	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	11.0
38	IL7	interleukin 7	11.0
39	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	11.0
40	HLA-DRB5	major histocompatibility complex, class II, DR beta 5	11.0
41	IL21	interleukin 21	11.0
42	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0
43	KLRK1	killer cell lectin-like receptor subfamily K, member 1	11.0
44	LCK	lymphocyte-specific protein tyrosine kinase	11.0
45	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0
46	SELL	selectin L	11.0
47	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0
48	PTPN3	protein tyrosine phosphatase, non-receptor type 3	11.0
49	TRH	thyrotropin-releasing hormone	11.0
50	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0

Pathways related to hypersensitivity reaction type ii disease according to GeneDecks:

(show top 50)    (show all 147)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.4	NCAM1, SELL, SELP, CD276, CD28, CD2
2	Lymphocyte Signaling3	10.4	NCAM1, LCK, B2M, CD8A, CD4, CD34
3	RAR-Gamma-RXR-Alpha Degradation36	10.3	CD2, CD80, IL2, IL21, IL23A, IL7
4	Antigen processing and presentation20	10.1	CD8A, CD4, HSPA4, HLA-C, HLA-DPB1, HLA-DQB1
5	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	BCL2, GZMB, IL2, IL2RA, FASLG, TNFRSF1A
6	Graft-versus-host disease20	9.6	CD28, CD86, CD80, IL1A, IL2, FASLG
7	Immune System38	9.6	NCAM1, VCAM1, CD79A, CD34, CD40, FCGR1A
8	Viral myocarditis20	9.4	CD28, CD86, CD40LG, CD80, CD40, ITGAL
9	Staphylococcus aureus infection20	9.3	SELP, ITGAL, ITGAM, FCGR1A, IL10, ICAM1
10	NFAT Signaling and Lymphocyte Interactions36	9.2	BCL2, CD2, CD4, CD80, IL13, IL1A
11	Regulation of eIF4 and p70S6K36	9.0	CD2, CD4, CD80, ITGA4, ITGAL, ITGAM
12	Molecular Mechanisms of Cancer36	9.0	BCL2, CD2, CD4, CD80, ITGA4, ITGAL
13	IL-6 Pathway36	8.8	CD2, CD80, IL10, IL18, IL23A, IL4
14	Natural killer cell mediated cytotoxicity20	8.5	LCK, ITGAL, GZMB, FASLG, FAS, IFNA1
15	Hematopoietic cell lineage20	8.2	MS4A1, CD2, CD8A, CD4, CD34, CD1D
16	PGC1Alpha Pathway36	8.1	BCL2, CD2, CD4, CD80, IL13, IL18
17	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.1	GZMB, IL17A, IL1B, IL21, IL23A, IL4
18	Th1 Differentiation37	8.1	CD28, CD86, CD4, CD80, IL10, IL18
19	Asthma20	8.0	CD40LG, CD40, IL10, IL13, IL4, IL5
20	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	7.7	FOXP3, IL10, IL2, IL2RA, FASLG, FAS
21	T cell receptor signaling pathway20	7.7	LCK, CD28, CD8A, CD4, CD40LG, IL10
22	Endothelin-1 Signaling Pathway36	7.7	CD2, CD80, IL10, IL13, IL18, IL1A
23	Akt Signaling36	7.7	CD28, CD2, CD4, CD80, ITGAL, ITGAM
24	Toxoplasmosis20	7.5	BCL2, CD40LG, CD40, IL10, CCR5, IFNG
25	THC Differentiation Pathway36	7.2	CD28, CD86, IL10, IL18, IL2, IL2RA
26	ERK Signaling36	7.0	CD2, CD80, ITGA4, ITGAL, ITGAM, FN1
27	Leishmaniasis20	7.0	ITGA4, ITGAM, FCGR1A, IL10, IL1A, IL1B
28	Rheumatoid arthritis20	7.0	CD28, CD86, CD80, ITGAL, IL17A, IL18
29	Tec Kinases Signaling36	7.0	BCL2, CD28, CD2, CD4, CD80, ITGA4
30	Autoimmune thyroid disease20	6.9	CD28, CD86, CD40LG, CD80, CD40, GZMB
31	Rho Family GTPases36	6.8	BCL2, CD2, CD80, ITGA4, ITGAL, ITGAM
32	Type I diabetes mellitus20	6.8	CD28, CD86, CD80, GZMB, INS, IL1A
33	Malaria20	6.8	SELE, SELP, VCAM1, CD40LG, CD40, ITGAL
34	SOCS Pathway36	6.6	BCL2, CD2, CD4, CD80, INS, IL10
35	Influenza A20	6.6	IL18, IL1A, IL1B, IL6, IL8, FASLG
36	TGF-Beta Pathway36	6.6	BCL2, CD2, CD4, CD80, IL10, IL13
37	Chagas disease (American trypanosomiasis)20	6.4	IL10, IL1B, IL2, IL6, IL8, FASLG
38	all-trans-Retinoic Acid Signaling in Brain36	6.4	BCL2, CD2, CD80, IL10, IL13, IL18
39	Allograft rejection20	6.3	CD28, CD86, CD40LG, CD80, CD40, GZMB
40	MIF Mediated Glucocorticoid Regulation36	6.1	BCL2, CD2, CD80, MIF, IL10, IL13
41	MIF Regulation of Innate Immune Cells36	6.1	BCL2, CD2, CD80, MIF, IL10, IL13
42	PEDF Induced Signaling36	6.1	BCL2, CD2, CD80, IL10, IL13, IL18
43	Tuberculosis20	6.1	VDR, BCL2, ITGAM, FCGR1A, IL10, IL18
44	PAK Pathway36	6.0	BCL2, CD2, CD80, IL10, IL13, IL18
45	MAPK Family Pathway36	5.8	BCL2, CD2, CD4, CD80, IL10, IL13
46	JAK-STAT Pathway36	5.8	BCL2, CD2, CD4, CD80, IL10, IL13
47	Cytokine Network36	5.8	IL10, IL13, IL18, IL1A, IL1B, IL2
48	Antioxidant Action of Vitamin-C36	5.7	BCL2, CD28, CD2, CD4, CD80, IL10
49	p38 Signaling36	5.7	BCL2, LCK, CD28, CD2, CD4, CD80
50	Cytokine-cytokine receptor interaction20	5.0	CD40LG, CD40, IL10, IL13, IL17A, IL18

Compounds related to hypersensitivity reaction type ii disease according to GeneDecks:

(show top 50)    (show all 447)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.9	CD2, GZMB, MIF, TRH, CTSG, PLG
2	ionomycin32	10.5	LCK, CD2, CD69, CD40, IL5, IL7
3	dmso32	10.3	SELP, ITGAM, ALPP, HSPG2, HSPA4, TNFRSF1A
4	sp 60012532 42	11.3	VCAM1, CD40, IL13, IL17A, CYCS, TLR2
5	fluvastatin32 34 9 9	13.0	VWF, SELP, VCAM1, CD40, ITGAL, IL1A
6	12-o-tetradecanoylphorbol 13-acetate32	9.9	NCAM1, LCK, CD4, CD34, CD44, ITGAM
7	oxygen32 18	10.4	SERPINA1, BCL2, BCR, LCK, SAG, MPO
8	ascorbic acid32 18	10.4	VDR, BGLAP, FTH1, CD40LG, ITGAM, IL1A
9	glutamate32	9.4	NCAM1, VDR, LCK, CD79A, CD4, CD40
10	cuprophan32	9.4	SELL, SELP, VCAM1, B2M, ITGAL, ITGAM
11	calcitriol32 42 9 18 9	13.4	VDR, BGLAP, B2M, CD44, ITGAL, ITGAM
12	estrogen32	9.4	VWF, SERPINA1, VDR, BGLAP, CD34, GZMB
13	pge232	9.3	SELE, VCAM1, SAG, CD69, CD86, CD4
14	formaldehyde32 18	10.3	VWF, SELE, SELL, SELP, B2M, MPO
15	endotoxin32	9.2	SELL, CD86, CD40, ITGAL, ITGAM, MIF
16	doxorubicin32 34 9 9	12.1	NCAM1, SELE, B2M, CD40LG, CD19, CD40
17	heparin32 9 18 9	12.0	NCAM1, VWF, SERPINA1, BGLAP, SAG, B3GAT1
18	calcium32 9 18 9	12.0	VWF, BGLAP, BCR, LCK, SAG, MS4A1
19	dextran sulfate32	9.0	SELE, SELL, SELP, MPO, CD4, CD40LG
20	wortmannin32 42	10.0	VCAM1, BCL2, CD28, CD2, CD86, CD80
21	arachidonic acid32 9 18 9	11.5	NCAM1, VWF, SELP, SERPINA1, CD69, CD4
22	sulfasalazine32 9 9	10.1	SELE, MPO, CD79A, CD40LG, IL1A, IL1B
23	con a32	8.1	CD28, CD79A, CD2, CD69, IL10, IL18
24	allergens32	7.9	CD79A, CD69, CD86, CD40LG, CD80, CD40
25	norepinephrine32 9 18 9	10.9	VWF, SELE, SELL, SELP, VCAM1, CD79A
26	arginine32	7.9	VWF, VDR, BGLAP, B3GAT1, CD79A, CD40LG
27	methacholine32 9 9	9.9	MPO, CD79A, ITGA4, IL13, IL17A, IL4
28	fibrinogen32	7.8	SELE, SELP, SERPINA1, VCAM1, CD79A, CD40LG
29	groalpha32	7.6	SELE, VCAM1, IL10, IL13, IL17A, IL18
30	butyrate32	7.6	RBP3, VDR, BCL2, B2M, MPO, CD86
31	cisplatin32 34 9 9	10.5	BGLAP, BCL2, B2M, MPO, CD40LG, CD44
32	curcumin32	7.4	VCAM1, BCL2, MIF, IL17A, IL18, IL1A
33	lipoteichoic acid32	7.3	SELE, IL10, IL18, IL1B, IL1RN, IL6
34	histamine32 18	8.2	NCAM1, VWF, SELE, SELL, SELP, VCAM1
35	pdtc32	7.2	SELE, VCAM1, BCL2, CD40, IL18, IL1A
36	cholesterol32 9 18 9	10.2	VWF, SELE, SELP, SERPINA1, VCAM1, BCR
37	glatiramer acetate32 9 9	9.1	MOG, IL10, IL13, IL2, IL4, IL5
38	glutamine32	7.1	NCAM1, VWF, RBP3, VDR, SAG, B2M
39	mip 1alpha32	6.9	IL10, IL13, IL1B, IL4, IL6, IL8
40	creatinine32	6.9	NCAM1, VWF, SELE, SELL, SELP, SERPINA1
41	lipid32	6.8	NCAM1, SELE, SERPINA1, VCAM1, BCR, LCK
42	infliximab32 9 9	8.0	SELE, BGLAP, ITGA4, IL10, IL17A, IL18
43	genistein32 9 18 9	8.8	SELE, SELL, SELP, VDR, VCAM1, BCL2
44	simvastatin32 34 42 9 18 9	10.7	VWF, SELE, SELL, SELP, VCAM1, BGLAP
45	pentoxifylline32 9 9	7.5	SELL, SELP, VCAM1, MPO, ITGA4, ITGAM
46	il-1232	5.4	CD86, CD40LG, IL10, IL13, IL18, IL1B
47	cyclosporin a32 42	5.9	VWF, SELP, VDR, BGLAP, SAG, B2M
48	nitric oxide32 9 18 9	7.6	NCAM1, VWF, RBP3, SELE, SELP, SERPINA1
49	retinoic acid32 42 18	6.3	NCAM1, VWF, RBP3, SELL, SELP, VDR
50	dexamethasone32 42 34 9 9	5.9	NCAM1, VWF, SELL, SELP, VDR, VCAM1

Cellular components related to hypersensitivity reaction type ii disease according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	10.1	HLA-DPB1, HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-DRB5
2	clathrin-coated endocytic vesicle membrane	GO:030669	10.0	HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DPB1, FCGR1A
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.8	HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DPB1, HLA-C
4	ER to Golgi transport vesicle membrane	GO:012507	9.8	HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DPB1, HLA-C
5	membrane raft	GO:045121	9.4	THY1, TLR4, PTPRC, TNFRSF1B, TNFRSF1A, TNF
6	platelet alpha granule lumen	GO:031093	9.3	TGFB1, PLG, ALB, F8, FN1, SERPINA1
7	secretory granule	GO:030141	9.0	POMC, LTF, PLAT, CTSG, TRH, HSPD1
8	cell surface	GO:009986	8.8	TPO, TNF, TNFRSF1A, CTSG, PLAT, TLR2
9	integral to plasma membrane	GO:005887	8.5	C5AR1, HLA-DRB1, HLA-C, HLA-B, HLA-A, ICOS
10	external side of plasma membrane	GO:009897	7.4	CD44, SELL, VWF, NCAM1, SELP, VCAM1
11	plasma membrane	GO:005886	7.1	TLR2, HLA-DRB1, HLA-DQB1, HLA-DPB1, HLA-C, HLA-B
12	extracellular region	GO:005576	4.9	POMC, CSF2, CXCL9, CXCL13, CXCL10, PRF1
13	extracellular space	GO:005615	2.9	TNF, GIF, HSPD1, HSPG2, ALPL, ALB

Biological processes related to hypersensitivity reaction type ii disease according to GeneDecks:

(show top 50)    (show all 90)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte migration	GO:050900	10.4	ITGAM, SELP, LCK, CD2, CD34, ITGA4
2	leukocyte cell-cell adhesion	GO:007159	10.4	SELP, SELE, VCAM1, CD40LG, ITGA4, CCL5
3	T cell receptor signaling pathway	GO:050852	10.4	LCK, HLA-DRB5, CD4, PTPN22, HLA-DPB1, HLA-DQB1
4	T cell activation	GO:042110	10.3	FOXP3, HSPD1, CD80, CD8A, CD86, CD276
5	T cell costimulation	GO:031295	10.3	ICOS, HLA-DPB1, HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-DRB5
6	detection of bacterium	GO:016045	10.3	HLA-DRB1, HLA-B, HLA-DRB5, HLA-DRB4, CD1D, HLA-A
7	cell surface receptor signaling pathway	GO:007166	10.2	CD28, IL2RA, PTPRC, TNFRSF25, TNFRSF13B, CXCL10
8	positive regulation of interleukin-10 production	GO:032733	10.2	HSPD1, CD34, CD40LG, IL21, IL23A, IL4
9	positive regulation of interleukin-12 production	GO:032735	10.1	CD40, TLR4, CD40LG, TLR2, HSPD1, IFNG
10	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.1	IL1A, IL1B, CD80, CD4, CD28, CD86
11	response to lipopolysaccharide	GO:032496	9.9	FASLG, SELE, SELP, SERPINA1, FAS, IL13
12	positive regulation of inflammatory response	GO:050729	9.8	TLR2, TNFRSF1A, IL21, IL2, TLR4, IL23A
13	defense response to virus	GO:051607	9.7	CXCL10, IFNG, CD86, BCL2, CD40, CXCL9
14	regulation of immune response	GO:050776	9.7	HLA-B, TRAC, ITGA4, CD40, CD19, HLA-C
15	positive regulation of isotype switching to IgG isotypes	GO:048304	9.6	CD40, PTPRC, TBX21, IFNG, IL4, IL2
16	B cell proliferation	GO:042100	9.6	HSPD1, IL10, CD40, CD79A, BCL2, PTPRC
17	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	TLR4, CD4, IL6, IL5, INS, MIF
18	negative regulation of T cell proliferation	GO:042130	9.5	FOXP3, TGFB1, HLA-DRB5, HLA-DRB4, HLA-DRB1, IL10
19	cellular response to mechanical stimulus	GO:071260	9.5	CD40, TNFRSF10A, TNFRSF1A, IL1B, NFKB1, TLR4
20	response to ethanol	GO:045471	9.5	IL13, PRF1, TLR4, TNFRSF1A, TRH, CCL2
21	platelet activation	GO:030168	9.4	PLG, SERPINA1, F8, ALB, TGFB1, LCK
22	B cell differentiation	GO:030183	9.3	VCAM1, IL4, PTPRC, CD40LG, ITGA4, IL10
23	positive regulation of B cell proliferation	GO:030890	9.3	CD40LG, IL13, BCL2, IL2, IL4, CD40
24	interferon-gamma-mediated signaling pathway	GO:060333	9.1	NCAM1, VCAM1, B2M, PTPN11, HLA-DRB5, HLA-DRB4
25	positive regulation of T cell proliferation	GO:042102	9.1	CD28, CD276, VCAM1, CD1D, PTPRC, IFNG
26	humoral immune response	GO:006959	9.1	TNF, AIRE, LTA, IFNG, CCL2, IL7
27	acute-phase response	GO:006953	9.1	SERPINA1, CRP, FN1, F8, IL6, IL1RN
28	lipopolysaccharide-mediated signaling pathway	GO:031663	9.0	CCL5, IL18, TLR4, TNF, IL1B, TLR2
29	signal transduction	GO:007165	9.0	IL21, TNFRSF25, CD4, CD34, POMC, ITGAL
30	positive regulation of interferon-gamma production	GO:032729	9.0	LTA, TNF, HSPD1, IL23A, IL2, CD40LG
31	cellular response to organic cyclic compound	GO:071407	9.0	TGFB1, TNF, ALPL, CCL5, CCL2, IL1B
32	positive regulation of MHC class II biosynthetic process	GO:045348	8.9	IL4, CD40LG, IL10, TLR4, IFNG
33	cellular response to lipopolysaccharide	GO:071222	8.9	TLR4, IL10, TSPO, TNFRSF1B, ICAM1, IFNG
34	negative regulation of growth of symbiont in host	GO:044130	8.8	TLR2, CTSG, TNF, IFNG, IL10, LTA
35	positive regulation of interleukin-6 production	GO:032755	8.8	TLR2, IL1A, TLR4, TNF, HSPD1, IL6
36	cell adhesion	GO:007155	8.7	IL2, VCAM1, NCAM1, VWF, SELL, SELP
37	positive regulation of nitric oxide biosynthetic process	GO:045429	8.6	TLR4, TLR2, TNF, IFNG, IL1B, INS
38	MAPK cascade	GO:000165	8.3	TGFB1, CCL5, CCR5, CCL2, IL1B, IL18
39	negative regulation of apoptotic process	GO:043066	8.1	TNF, BCL2, INS, HSPD1, CSF2, CD44
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.1	CD40, IL1B, IL6, ICAM1, TNF, NFKB1
41	cell-cell signaling	GO:007267	8.1	POMC, IL18, IL17A, IL13, IL10, INS
42	apoptotic process	GO:006915	8.0	TNFRSF1B, TNFRSF25, DDX41, CYCS, NFKB1, TSPO
43	response to hypoxia	GO:001666	7.9	TRH, FAS, IL1B, IL1A, IL18, BCL2
44	response to glucocorticoid stimulus	GO:051384	7.9	IL1B, PLAT, TNF, ALPL, CCL2, CCL5
45	cytokine-mediated signaling pathway	GO:019221	7.9	NCAM1, VCAM1, B2M, CD44, FCGR1A, HLA-DRB1
46	immune response	GO:006955	7.5	C5AR1, CSF2, CXCL9, CXCL13, CXCL10, TLR4
47	response to drug	GO:042493	7.3	LTA, BGLAP, BCL2, LCK, IL10, TNF
48	anti-apoptosis	GO:006916	7.3	TNFRSF18, TNF, CCL2, FAS, IL2, IL1B
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	TNFRSF1A, DDX41, NFKB1, TLR2, TLR4, TGFB1
50	inflammatory response	GO:006954	6.2	TNFRSF1B, CXCL10, TLR2, NFKB1, IL17A, CCL5

Molecular functions related to hypersensitivity reaction type ii disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor-activated receptor activity	GO:005031	10.4	TNFRSF25, TNFRSF1B, TNFRSF1A, TNFRSF18, TNFRSF17, FAS
2	coreceptor activity	GO:015026	10.4	CCR5, CD80, CD4, CD8A, CD86, CD28
3	glycoprotein binding	GO:001948	10.2	ITGAM, CD5, CD4, LCK, SELP, VWF
4	receptor activity	GO:004872	10.1	TNFRSF10A, TNFRSF13B, TNFRSF17, TNFRSF25, TLR2, TLR4
5	transmembrane signaling receptor activity	GO:004888	9.9	TLR4, TLR2, ICAM1, CD44, CD5, CD4
6	heparin binding	GO:008201	9.9	CXCL13, LTF, CTSG, PTPRC, CCL5, CCL2
7	chemokine activity	GO:008009	9.6	CXCL9, CXCL13, CXCL10, CCL5, CCL2, IL8
8	protease binding	GO:002020	9.3	TNFRSF1A, TNF, MBP, INS, CD28, BCL2
9	growth factor activity	GO:008083	7.5	TGFB1, IL7, IL6, IL5, IL4, IL2
10	cytokine activity	GO:005125	6.4	IL23A, IL4, IL5, IL6, IL7, FASLG
11	protein binding	GO:005515	4.3	TNFRSF13B, NFKB1, LTF, WDTC1, TSHR, TLR2