MCID: HYP071
MIFTS: 33

Hypersensitivity Reaction Type Ii Disease malady

Immune diseases category

Summaries for Hypersensitivity Reaction Type Ii Disease

About this section


MedlinePlus:32 Your body's immune system protects you from disease and infection. but if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. autoimmune diseases can affect many parts of the body. no one is sure what causes autoimmune diseases. they do tend to run in families. women - particularly african-american, hispanic-american, and native-american women - have a higher risk for some autoimmune diseases. there are more than 80 types of autoimmune diseases, and some have similar symptoms. this makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. getting a diagnosis can be frustrating and stressful. often, the first symptoms are fatigue, muscle aches and a low fever. the classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. the diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. treatment depends on the disease, but in most cases one important goal is to reduce inflammation. sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards based summary: Hypersensitivity Reaction Type Ii Disease, also known as autoimmune diseases, is related to myasthenia gravis and rheumatoid arthritis, and has symptoms including abnormality of metabolism/homeostasisand autoimmunity. An important gene associated with Hypersensitivity Reaction Type Ii Disease is TRAC (T cell receptor alpha constant), and among its related pathways are Translocation of ZAP-70 to Immunological synapse and TCR signaling. The drugs methylprednisolone and prednisone and the compound ricin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:9 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or t cell directed against the host tissues.

Aliases & Classifications for Hypersensitivity Reaction Type Ii Disease

About this section

Hypersensitivity Reaction Type Ii Disease, Aliases & Descriptions:

Name: Hypersensitivity Reaction Type Ii Disease 9 11
Autoimmune Diseases 43 32 60
 
Autoimmune Disease 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:417
ICD9CM27 720
MeSH33 D001327

Related Diseases for Hypersensitivity Reaction Type Ii Disease

About this section

Diseases in the Hypersensitivity Reaction Type Ii Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Type Ii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 295)
idRelated DiseaseScoreTop Affiliating Genes
1myasthenia gravis30.3MOG, AIRE
2rheumatoid arthritis29.9HLA-DQB3, HLA-DRB4, MOG, CD5, CD19
3thymoma29.9CD5, AIRE
4skin disease29.9LYZ, PRF1
5leukemia29.5LYZ, CD5, CD19, TRAC
6arthritis10.5
7systemic lupus erythematosus10.5
8lupus erythematosus10.5
9thyroiditis10.5
10pemphigus10.3
11hepatitis10.3
12primary biliary cirrhosis10.3
13vitiligo-associated multiple autoimmune disease susceptibility 110.3
14familial mediterranean fever, ar10.3
15antiphospholipid syndrome10.3
16autoimmune disease of cardiovascular system10.3
17autoimmune disease of eyes, ear, nose and throat10.3
18goodpasture syndrome10.3
19sjogren's syndrome10.3
20vogt-koyanagi-harada disease10.3
21alopecia areata10.3
22autoimmune disease of blood10.3
23autoimmune disease of endocrine system10.3
24autoimmune disease of gastrointestinal tract10.3
25autoimmune disease of skin and connective tissue10.3
26autoimmune disease of urogenital tract10.3
27celiac disease10.3
28endotheliitis10.3
29graves' disease10.2
30vasculitis10.2
31alopecia10.2
32autoimmune hepatitis10.2
33malt lymphoma10.2
34hepatitis c10.2
35bullous pemphigoid10.2
36addison's disease10.2
37scleroderma10.2
38atherosclerosis10.2
39stiff-person syndrome10.2
40dermatomyositis10.2
41lymphopenia10.2
42uveitis10.2
43autoimmune disease 110.1
44autoimmune disease 610.1
45autoimmune disease, multisystem, infantile-onset10.1
46glomerulonephritis10.1
47autoimmune disease of musculoskeletal system10.1
48autoimmune disease of central nervous system10.1
49mixed connective tissue disease10.1
50autoimmune disease of the nervous system10.1

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Ii Disease:



Diseases related to hypersensitivity reaction type ii disease

Symptoms for Hypersensitivity Reaction Type Ii Disease

About this section

HPO human phenotypes related to Hypersensitivity Reaction Type Ii Disease:

id Description Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis HP:0001939
2 autoimmunity HP:0002960

Drugs & Therapeutics for Hypersensitivity Reaction Type Ii Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Hypersensitivity Reaction Type Ii Disease

Search NIH Clinical Center for Hypersensitivity Reaction Type Ii Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hypersensitivity Reaction Type Ii Disease

About this section

Anatomical Context for Hypersensitivity Reaction Type Ii Disease

About this section

MalaCards organs/tissues related to Hypersensitivity Reaction Type Ii Disease:

31
T cells

Animal Models for Hypersensitivity Reaction Type Ii Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Ii Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2AIRE, PRF1, TBX21, CD19
2MP:00053847.9CD19, TBX21, MOG, PRF1, AIRE
3MP:00053977.3CD19, CD5, TBX21, MOG, PRF1, AIRE
4MP:00053877.2AIRE, PRF1, MOG, TBX21, CD5, CD19

Publications for Hypersensitivity Reaction Type Ii Disease

About this section

Variations for Hypersensitivity Reaction Type Ii Disease

About this section

Expression for genes affiliated with Hypersensitivity Reaction Type Ii Disease

About this section
Search GEO for disease gene expression data for Hypersensitivity Reaction Type Ii Disease.

Pathways for genes affiliated with Hypersensitivity Reaction Type Ii Disease

About this section

Compounds for genes affiliated with Hypersensitivity Reaction Type Ii Disease

About this section
Sources:
43Novoseek
See all sources

Compounds related to Hypersensitivity Reaction Type Ii Disease according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1ricin439.6CD19, CD5

GO Terms for genes affiliated with Hypersensitivity Reaction Type Ii Disease

About this section

Cellular components related to Hypersensitivity Reaction Type Ii Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0CD19, CD5, HLA-DRB4
2plasma membraneGO:00058867.5TRAC, CD19, CD5, MOG, PRF1, HLA-DRB4

Biological processes related to Hypersensitivity Reaction Type Ii Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:00507769.8TRAC, CD19
2T cell receptor signaling pathwayGO:00508529.6TRAC, HLA-DRB4
3T cell costimulationGO:00312959.4TRAC, CD5, HLA-DRB4
4cytolysisGO:00198359.2LYZ, PRF1
5cellular defense responseGO:00069689.2PRF1, CD19

Products for genes affiliated with Hypersensitivity Reaction Type Ii Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hypersensitivity Reaction Type Ii Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet