MCID: HYP073
MIFTS: 35

Hypersensitivity Reaction Type Iv Disease

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Hypersensitivity Reaction Type Iv Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iv Disease:

Name: Hypersensitivity Reaction Type Iv Disease 12 14
Immunoproliferative Disorders 41 69
Immunoproliferative Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2916
ICD10 32 C88.9 C88
MeSH 41 D007160
UMLS 69 C0021070

Summaries for Hypersensitivity Reaction Type Iv Disease

MalaCards based summary : Hypersensitivity Reaction Type Iv Disease, also known as immunoproliferative disorders, is related to heavy chain disease and autoimmune lymphoproliferative syndrome. An important gene associated with Hypersensitivity Reaction Type Iv Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Hypersensitivity Reaction Type Iv Disease

Diseases in the Hypersensitivity Reaction Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Type Iv Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 heavy chain disease 32.4 CD40LG CD79A
2 autoimmune lymphoproliferative syndrome 30.9 CASP10 FAS IL2
3 sarcoidosis 1 30.7 ACE BTNL2 IFNG NOD2 TNF TNFRSF1B
4 cryoglobulinemia 11.1
5 cerebral sarcoidosis 10.6 ACE LYZ
6 selective igg deficiency disease 10.6 CD40LG CD79A
7 c1q nephropathy 10.6 CD40LG CD79A
8 cardiovascular syphilis 10.6 CD40LG SMUG1
9 meningovascular neurosyphilis 10.6 CD40LG CD79A
10 alpha chain disease 10.6 CD40LG CD79A
11 brill-zinsser disease 10.6 CD40LG CD79A
12 exudative glomerulonephritis 10.6 CD40LG CD79A
13 cork-handlers' disease 10.6 CD40LG CD79A
14 salpingo-oophoritis 10.6 CD40LG CD79A
15 early yaws 10.6 CD40LG CD79A
16 ventilation pneumonitis 10.6 CD40LG CD79A
17 chronic interstitial cystitis 10.6 CD40LG CD79A
18 axillary adenitis 10.6 CD40LG CD79A
19 cryofibrinogenemia 10.6 CD40LG CD79A
20 ulcerative blepharitis 10.6 CD79A LYZ
21 trichostrongyloidiasis 10.6 CD40LG CD79A
22 subacute bacterial endocarditis 10.6 CD40LG CD79A
23 heterophyiasis 10.6 CD40LG CD79A
24 immunoglobulin g deficiency 10.5 CD40LG CD79A
25 anthracosilicosis 10.5 ACE SMUG1
26 orbital granuloma 10.5 CD40LG CD79A
27 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
28 subacute cutaneous lupus erythematosus 10.5 ACE TNF
29 hyperglobulinemic purpura 10.5 CD40LG CD79A
30 gastroduodenitis 10.5 CD40LG CD79A
31 bacterial conjunctivitis 10.5 CD40LG CD79A
32 polyclonal hypergammaglobulinemia 10.5 CD40LG CD79A MYOM2
33 chronic polyneuropathy 10.5 CD40LG CD79A MYOM2
34 neuroretinitis 10.5 ACE CD40LG LYZ
35 autoimmune disease of urogenital tract 10.5 CD40LG CD79A TLR9
36 plasma protein metabolism disease 10.5 CD40LG CD79A MYOM2
37 plasma cell neoplasm 10.5 CD40LG CD79A MYOM2
38 meningoencephalitis 10.5 CD40LG CD79A TLR9
39 rectum squamous cell carcinoma 10.5 SMUG1 TNFRSF1B
40 b cell deficiency 10.5 CD40LG CD79A TLR9
41 endocardium disease 10.5 CD40LG CD79A SMUG1
42 lung lymphoma 10.5 CD40LG CD79A SMUG1
43 diffuse glomerulonephritis 10.5 CD40LG CD79A LYZ
44 acute proliferative glomerulonephritis 10.5 CD40LG CD79A LYZ
45 ophthalmia neonatorum 10.4 CD40LG CD79A
46 pyelitis 10.4 CD40LG CD79A LYZ
47 rheumatic heart disease 10.4 ACE MYOM2 TNF
48 pulmonary hemosiderosis 10.4 CD40LG CD79A LYZ
49 jejunoileitis 10.4 CD40LG CD79A TNF
50 pneumocystosis 10.4 CD40LG CD79A TNF

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iv Disease:



Diseases related to Hypersensitivity Reaction Type Iv Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Type Iv Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 FAS IL2 NOD2 TNF TNFRSF1B ACE
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 FAS IL2 NOD2 TNF TNFRSF1B ACE

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iv Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 TLR9 TNF TNFRSF1B SMUG1 CD79A LYZ
2 hematopoietic system MP:0005397 10.15 TNF TNFRSF1B TLR9 LYZ FAS NOD2
3 homeostasis/metabolism MP:0005376 10.13 TLR9 TNF TNFRSF1B NOD2 SMUG1 IL2
4 immune system MP:0005387 10.03 TNF TNFRSF1B TLR9 LYZ FAS NOD2
5 digestive/alimentary MP:0005381 10.01 TLR9 TNF TNFRSF1B NOD2 IL2 LYZ
6 liver/biliary system MP:0005370 9.76 TNF TNFRSF1B IL2 CD79A LYZ FAS
7 neoplasm MP:0002006 9.61 TNF TNFRSF1B SMUG1 LYZ FAS IFNG
8 renal/urinary system MP:0005367 9.23 TLR9 TNFRSF1B CD79A LYZ FAS IFNG

Drugs & Therapeutics for Hypersensitivity Reaction Type Iv Disease

Search Clinical Trials , NIH Clinical Center for Hypersensitivity Reaction Type Iv Disease

Cochrane evidence based reviews: immunoproliferative disorders

Genetic Tests for Hypersensitivity Reaction Type Iv Disease

Anatomical Context for Hypersensitivity Reaction Type Iv Disease

Publications for Hypersensitivity Reaction Type Iv Disease

Articles related to Hypersensitivity Reaction Type Iv Disease:

# Title Authors Year
1
Alpha-chain disease: an immunoproliferative disease of the secretory immune system. ( 6408973 )
1983

Variations for Hypersensitivity Reaction Type Iv Disease

Expression for Hypersensitivity Reaction Type Iv Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iv Disease.

Pathways for Hypersensitivity Reaction Type Iv Disease

Pathways related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 BTNL2 CASP10 CD40LG CD79A IFNG IL1RN
2
Show member pathways
13.32 CD40LG IFNG IL1RN IL2 NOD2 TNF
3
Show member pathways
12.8 CD40LG FAS IFNG IL2 TNF
4
Show member pathways
12.74 FAS IFNG IL2 TLR9 TNF
5
Show member pathways
12.65 CD40LG IL2 TLR9 TNF TNFRSF1B
6
Show member pathways
12.6 CD40LG FAS IFNG TNF TNFRSF1B
7
Show member pathways
12.56 CD40LG CD79A IFNG IL2 TNF TNFRSF1B
8
Show member pathways
12.55 CASP10 CD40LG FAS TLR9 TNF TNFRSF1B
9
Show member pathways
12.4 ACE FAS IFNG IL2 TLR9 TNF
10
Show member pathways
12.38 CD40LG FAS IFNG IL2 TNF
11
Show member pathways
12.28 CASP10 FAS TNF TNFRSF1B
12 12.2 CD40LG FAS TNF TNFRSF1B
13
Show member pathways
12.13 FAS IFNG TLR9 TNF
14 12.13 CASP10 IFNG NOD2 TLR9 TNF
15 11.95 CD79A IFNG IL2 TNF
16
Show member pathways
11.88 IFNG IL2 TLR9 TNF
17 11.79 CD40LG CD79A FAS IFNG IL1RN IL2
18
Show member pathways
11.75 CD40LG FAS TNF TNFRSF1B
19 11.75 CASP10 FAS NOD2 TNF TNFRSF1B
20 11.74 IFNG IL2 TNF
21
Show member pathways
11.69 CD40LG TNF TNFRSF1B
22
Show member pathways
11.69 CD40LG IFNG IL2 TNF
23 11.66 IFNG IL2 TLR9 TNF
24 11.64 CD40LG TLR9 TNF
25
Show member pathways
11.6 IFNG IL2 TNF
26
Show member pathways
11.56 CD40LG IFNG IL2 TNF
27
Show member pathways
11.5 IFNG TNF TNFRSF1B
28 11.48 IL1RN TNF TNFRSF1B
29 11.46 IFNG IL2 TNF
30 11.41 FAS IFNG IL2 TNF
31 11.36 CD40LG IFNG TLR9 TNF
32 11.23 IFNG IL2 TNF
33 11.1 FAS IFNG TLR9 TNF
34 10.98 CD40LG IFNG IL2 TNFRSF1B
35
Show member pathways
10.91 FAS IFNG IL2 TNF TNFRSF1B

GO Terms for Hypersensitivity Reaction Type Iv Disease

Cellular components related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 ACE CD40LG IFNG IL1RN IL2 LYZ
2 external side of plasma membrane GO:0009897 9.62 ACE CD40LG CD79A TNF
3 membrane raft GO:0045121 9.46 CD79A FAS TNF TNFRSF1B
4 extracellular region GO:0005576 9.32 ACE CD40LG FAS IFNG IL1RN IL2
5 CD95 death-inducing signaling complex GO:0031265 8.96 CASP10 FAS

Biological processes related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.99 CD40LG IFNG IL1RN IL2 TNF
2 cell surface receptor signaling pathway GO:0007166 9.92 CASP10 CD79A IFNG TNFRSF1B
3 defense response to bacterium GO:0042742 9.88 LYZ NOD2 TLR9 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.86 CASP10 NOD2 TLR9 TNF
5 positive regulation of protein phosphorylation GO:0001934 9.84 FAS IFNG IL2 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 CD40LG NOD2 TLR9 TNF
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 CD40LG FAS TNF TNFRSF1B
8 positive regulation of JNK cascade GO:0046330 9.77 NOD2 TLR9 TNF
9 positive regulation of T cell proliferation GO:0042102 9.75 BTNL2 CD40LG IL2
10 positive regulation of interleukin-6 production GO:0032755 9.72 NOD2 TLR9 TNF
11 immune response GO:0006955 9.7 CD40LG FAS IFNG IL1RN IL2 TNF
12 positive regulation of interleukin-8 production GO:0032757 9.63 NOD2 TLR9 TNF
13 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.62 NOD2 TLR9
14 apoptotic signaling pathway GO:0097190 9.62 CASP10 FAS TNF TNFRSF1B
15 positive regulation of interleukin-17 production GO:0032740 9.61 IL2 NOD2
16 maintenance of gastrointestinal epithelium GO:0030277 9.61 NOD2 TLR9
17 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG IFNG TLR9
18 necroptotic signaling pathway GO:0097527 9.57 FAS TNF
19 positive regulation of interleukin-10 production GO:0032733 9.54 CD40LG NOD2 TLR9
20 regulation of immunoglobulin secretion GO:0051023 9.52 CD40LG TNF
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG TNF
22 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 IFNG TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IFNG TNF TNFRSF1B
24 extrinsic apoptotic signaling pathway GO:0097191 9.26 FAS IFNG TNF TNFRSF1B
25 inflammatory response GO:0006954 9.17 CD40LG FAS IL1RN LYZ TLR9 TNF

Molecular functions related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CD40LG IFNG IL1RN IL2 TNF
2 peptidyl-dipeptidase activity GO:0008241 8.96 ACE ENSG00000264813

Sources for Hypersensitivity Reaction Type Iv Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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