MCID: HYP074
MIFTS: 52

Hypersensitivity Vasculitis

Categories: Rare diseases, Cardiovascular diseases, Bone diseases, Immune diseases

Aliases & Classifications for Hypersensitivity Vasculitis

MalaCards integrated aliases for Hypersensitivity Vasculitis:

Name: Hypersensitivity Vasculitis 12 49 14
Cutaneous Small Vessel Vasculitis 49 55 69
Vasculitis, Leukocytoclastic, Cutaneous 41 69
Cutaneous Leukocytoclastic Vasculitis 49 55
Cutaneous Leukocytoclastic Angiitis 49 55
Hypersensitivity Angiitis 49 55
Cutaneous Hypersensitivity Vasculitis 55
Drug Induced Cutaneous Vasculitis 69
Vasculitis Hypersensitivity 72
Leukocytoclastic Vasculitis 69
Leukocytoclastic Angiitis 49

Characteristics:

Orphanet epidemiological data:

55
cutaneous leukocytoclastic angiitis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



Summaries for Hypersensitivity Vasculitis

NIH Rare Diseases : 49 Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance that leads to inflammation and damage to blood vessels of the skin. Signs and symptoms may include purple-colored spots and patches on the skin; skin lesions on the legs, buttocks, or trunk; blisters on the skin; hives (urticaria); and/or open sores with dead tissue (necrotic ulcers). This condition is caused by an allergic reaction to a drug or other foreign substance. This condition usually goes away over time; but on occasion, people can have repeated episodes. Last updated: 12/14/2011

MalaCards based summary : Hypersensitivity Vasculitis, also known as cutaneous small vessel vasculitis, is related to vasculitis and purpura, and has symptoms including abnormality of the oral cavity, cutis marmorata and purpura. An important gene associated with Hypersensitivity Vasculitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Dapsone and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast, and related phenotype is immune system.

Wikipedia : 72 Cutaneous small-vessel vasculitis, also known as hypersensitivity vasculitis, cutaneous leukocytoclastic... more...

Related Diseases for Hypersensitivity Vasculitis

Diseases related to Hypersensitivity Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.5 CD40LG CD79A CRP MEFV MPO
2 purpura 30.4 CD40LG CD79A CRP
3 mononeuritis multiplex 29.8 CD40LG CRP MPO
4 churg-strauss syndrome 29.4 CD40LG MPO
5 lupus erythematosus 29.3 C3 C4A CD40LG
6 systemic lupus erythematosus 28.4 C3 C4A CD40LG CD79A CRP MPO
7 allergic cutaneous vasculitis 11.0
8 allergic hypersensitivity disease 10.6
9 intestinal tuberculosis 10.5 CD79A CRP
10 aortitis 10.5 CRP MPO
11 mediastinitis 10.5 CRP MPO
12 maxillary sinusitis 10.5 CD79A MPO
13 goodpasture syndrome 10.5 CD79A MPO
14 pulmonary aspergilloma 10.5 CRP MPO
15 selective igg deficiency disease 10.5 CD40LG CD79A
16 c1q nephropathy 10.5 CD40LG CD79A
17 meningovascular neurosyphilis 10.5 CD40LG CD79A
18 alpha chain disease 10.5 CD40LG CD79A
19 brill-zinsser disease 10.5 CD40LG CD79A
20 exudative glomerulonephritis 10.5 CD40LG CD79A
21 acalculous cholecystitis 10.5 CD40LG CRP
22 cork-handlers' disease 10.5 CD40LG CD79A
23 salpingo-oophoritis 10.5 CD40LG CD79A
24 early yaws 10.5 CD40LG CD79A
25 ventilation pneumonitis 10.5 CD40LG CD79A
26 relapsing fever 10.5 CRP MEFV
27 chronic interstitial cystitis 10.5 CD40LG CD79A
28 axillary adenitis 10.5 CD40LG CD79A
29 cryofibrinogenemia 10.5 CD40LG CD79A
30 trichostrongyloidiasis 10.5 CD40LG CD79A
31 subacute bacterial endocarditis 10.5 CD40LG CD79A
32 heterophyiasis 10.5 CD40LG CD79A
33 immunoglobulin g deficiency 10.5 CD40LG CD79A
34 orbital granuloma 10.5 CD40LG CD79A
35 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
36 hyperglobulinemic purpura 10.5 CD40LG CD79A
37 gastroduodenitis 10.5 CD40LG CD79A
38 bacterial conjunctivitis 10.5 CD40LG CD79A
39 amyloidosis aa 10.5 CRP MEFV
40 heavy chain disease 10.5 CD40LG CD79A
41 ophthalmia neonatorum 10.5 CD40LG CD79A
42 immunoglobulin a deficiency 1 10.5 CD40LG CD79A
43 parotid disease 10.5 CD40LG CD79A
44 cerebral arteritis 10.5 CD40LG CD79A
45 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
46 geniculate herpes zoster 10.4 CD40LG CD79A
47 erythema elevatum diutinum 10.4 CD40LG CD79A
48 sporotrichosis 10.4 CD40LG CD79A
49 fallopian tube disease 10.4 CD40LG CD79A
50 hyperimmunoglobulin syndrome 10.4 CD40LG CD79A

Comorbidity relations with Hypersensitivity Vasculitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Postinflammatory Pulmonary Fibrosis
Rheumatoid Arthritis Systemic Lupus Erythematosus

Graphical network of the top 20 diseases related to Hypersensitivity Vasculitis:



Diseases related to Hypersensitivity Vasculitis

Symptoms & Phenotypes for Hypersensitivity Vasculitis

Human phenotypes related to Hypersensitivity Vasculitis:

55 31 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the oral cavity 55 31 occasional (7.5%) Occasional (29-5%) HP:0000163
2 cutis marmorata 55 31 hallmark (90%) Very frequent (99-80%) HP:0000965
3 purpura 55 31 hallmark (90%) Very frequent (99-80%) HP:0000979
4 skin rash 55 31 frequent (33%) Frequent (79-30%) HP:0000988
5 urticaria 55 31 hallmark (90%) Very frequent (99-80%) HP:0001025
6 subcutaneous nodule 55 31 occasional (7.5%) Occasional (29-5%) HP:0001482
7 recurrent skin infections 55 31 hallmark (90%) Very frequent (99-80%) HP:0001581
8 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
9 vasculitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0002633
10 arthralgia 55 31 frequent (33%) Frequent (79-30%) HP:0002829
11 myalgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0003326
12 erythema 55 31 hallmark (90%) Very frequent (99-80%) HP:0010783
13 gangrene 55 31 hallmark (90%) Very frequent (99-80%) HP:0100758
14 papule 55 31 hallmark (90%) Very frequent (99-80%) HP:0200034

MGI Mouse Phenotypes related to Hypersensitivity Vasculitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 C1GALT1 C3 CD40LG CD79A CRP HSP90AA1

Drugs & Therapeutics for Hypersensitivity Vasculitis

Drugs for Hypersensitivity Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Anti-Infective Agents Phase 4
5 Folic Acid Antagonists Phase 4
6 Vitamin B Complex Phase 4
7 Anti-Bacterial Agents Phase 4
8 Antimalarials Phase 4
9 Antiprotozoal Agents Phase 4
10 Antiparasitic Agents Phase 4
11 Folate Nutraceutical Phase 4
12 Vitamin B9 Nutraceutical Phase 4
13 Omega 3 Fatty Acid Nutraceutical Phase 4
14
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
15
Prednisolone Approved, Vet_approved 50-24-8 5755
16
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
17
Lenograstim Approved, Investigational 135968-09-1
18
Methylprednisolone Approved, Vet_approved 83-43-2 6741
19
Prednisone Approved, Vet_approved 53-03-2 5865
20 Prednisolone acetate
21 Alkylating Agents
22 glucocorticoids
23 Methylprednisolone acetate
24 Methylprednisolone Hemisuccinate
25 Gastrointestinal Agents
26 Neuroprotective Agents
27 Cyclosporins
28 Hormone Antagonists
29 Dermatologic Agents
30 Hormones
31 Hormones, Hormone Substitutes, and Hormone Antagonists
32 Peripheral Nervous System Agents
33 Antiemetics
34 Immunoglobulin A
35 Antifungal Agents
36 Immunoglobulins
37 Antigen-Antibody Complex
38 Antilymphocyte Serum
39 Prednisolone hemisuccinate
40 Immunosuppressive Agents
41 Prednisolone phosphate
42 Anti-Inflammatory Agents
43 Protective Agents
44 Antineoplastic Agents, Hormonal
45 Antibodies
46 Autonomic Agents
47 Antirheumatic Agents
48 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
2 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
3 IgA-positive Versus IgA-negative Immune Complex Vasculitis Unknown status NCT01815190
4 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
5 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129

Search NIH Clinical Center for Hypersensitivity Vasculitis

Cochrane evidence based reviews: vasculitis, leukocytoclastic, cutaneous

Genetic Tests for Hypersensitivity Vasculitis

Anatomical Context for Hypersensitivity Vasculitis

MalaCards organs/tissues related to Hypersensitivity Vasculitis:

38
Skin, Bone, Breast, Thyroid, Liver

Publications for Hypersensitivity Vasculitis

Articles related to Hypersensitivity Vasculitis:

(show top 50) (show all 70)
# Title Authors Year
1
Revisiting clinical differences between hypersensitivity vasculitis and Henoch-SchAPnlein purpura in adults from a defined population. ( 24528895 )
2014
2
Carbimazole-associated hypersensitivity vasculitis in a cat. ( 24255992 )
2013
3
Paracetamol-induced hypersensitivity vasculitis in a 10-year-old child. ( 24379075 )
2013
4
Ink sick: tattoo ink hypersensitivity vasculitis. ( 21035978 )
2011
5
Hypersensitivity vasculitis associated with leuprolide (Lupron). ( 20470239 )
2010
6
Hepatitis C- and human immunodeficiency virus-induced hypersensitivity vasculitis: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. ( 19921341 )
2010
7
A stinging rash of indeterminate origin. Idiopathic hypersensitivity vasculitis. ( 19235501 )
2009
8
Hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor. ( 20204065 )
2009
9
A case of hypersensitivity vasculitis after vinorelbine injection in a patient with metastatic breast cancer. ( 17419038 )
2007
10
Immunological diagnosis of cutaneous-pulmonary hypersensitivity vasculitis. ( 17332983 )
2007
11
Renal hypersensitivity vasculitis associated with dapsone. ( 16183407 )
2005
12
Prevalence of human parvovirus B19 component NS1 gene in patients with Henoch-Schonlein purpura and hypersensitivity vasculitis. ( 15888184 )
2005
13
Hypersensitivity vasculitis induced by cefoperazone/sulbactam. ( 12556245 )
2003
14
Hypersensitivity vasculitis with leukocytoclastic vasculitis secondary to infliximab. ( 12702983 )
2003
15
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. ( 12700924 )
2003
16
Hypersensitivity vasculitis and cytokines. ( 12426663 )
2002
17
Hypersensitivity vasculitis induced by cefprozil. ( 17159422 )
2002
18
Hypersensitivity vasculitis in adults: a benign disease usually limited to skin. ( 11247332 )
2001
19
Are Henoch-SchAPnlein purpura and hypersensitivity vasculitis in adults truly distinct entities? A dermatologist's perspective. ( 11138325 )
2000
20
Comparative clinical and epidemiological study of hypersensitivity vasculitis versus Henoch-SchAPnlein purpura in adults. ( 10406408 )
1999
21
Hypersensitivity vasculitis (microscopic polyangiitis) in pregnancy with transmission to the neonate. ( 9746391 )
1998
22
Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. ( 9790279 )
1998
23
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. ( 9724175 )
1998
24
Bilateral leg pain and bruising. Hypersensitivity vasculitis. ( 9305435 )
1997
25
Hypersensitivity vasculitis related to aceclofenac. ( 9159552 )
1997
26
Clinical features and outcome of 95 patients with hypersensitivity vasculitis. ( 9217569 )
1997
27
Hypersensitivity vasculitis--not always benign? ( 9251631 )
1997
28
Hypersensitivity vasculitis. ( 9329546 )
1997
29
Severe cutaneous thrombotic hypersensitivity vasculitis. ( 9385997 )
1997
30
Nonsteroidal antiinflammatory drug induced hypersensitivity vasculitis clinically mimicking temporal arteritis. ( 8838531 )
1996
31
Case report: ofloxacin-induced hypersensitivity vasculitis. ( 8615379 )
1996
32
Therapy of resistant systemic necrotizing vasculitis. Polyarteritis, Churg-Strauss syndrome, Wegener's granulomatosis, and hypersensitivity vasculitis group disorders. ( 7732173 )
1995
33
Idiopathic hypersensitivity vasculitis: clinicopathologic correlation of 61 cases. ( 8543412 )
1995
34
Hypersensitivity vasculitis of the duodenum. ( 8092020 )
1994
35
Hypersensitivity vasculitis associated with piperazine therapy. ( 8043407 )
1994
36
Ciprofloxacin-induced hypersensitivity vasculitis. ( 7941927 )
1994
37
Ciprofloxacin induced hypersensitivity vasculitis syndrome. ( 8262601 )
1993
38
Hypersensitivity vasculitis and Henoch-SchAPnlein purpura: a comparison between the 2 disorders. ( 8350321 )
1993
39
Hypersensitivity vasculitis and systemic lupus erythematosus induced by anticonvulsants. ( 8422654 )
1993
40
Hypersensitivity vasculitis related to nicoumalone. ( 8490477 )
1993
41
Acute hantavirus infection presenting as hypersensitivity vasculitis with arthropathy. ( 8095959 )
1993
42
Experimental steroid-induced osteonecrosis in adult rabbits with hypersensitivity vasculitis. ( 1555358 )
1992
43
Elimination diet in the treatment of selected patients with hypersensitivity vasculitis. ( 1505105 )
1992
44
Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure. ( 1424898 )
1992
45
Systemic hypersensitivity vasculitis associated with bronchiectasis. ( 1386569 )
1992
46
Hypersensitivity vasculitis and Henoch-SchAPnlein purpura: a comparison between the 2 disorders. ( 1613701 )
1992
47
Hypersensitivity vasculitis occurring in a patient receiving immunotherapy. ( 1826508 )
1991
48
Cutaneous vasculitis, hypersensitivity vasculitis, erythema nodosum, and pyoderma gangrenosum. ( 2043448 )
1991
49
Cutaneous vasculitis, hypersensitivity vasculitis, erythema nodosum, and pyoderma gangrenosum. ( 2223458 )
1990
50
Differential diagnosis of hypersensitivity vasculitis. ( 2268961 )
1990

Variations for Hypersensitivity Vasculitis

Expression for Hypersensitivity Vasculitis

Search GEO for disease gene expression data for Hypersensitivity Vasculitis.

Pathways for Hypersensitivity Vasculitis

GO Terms for Hypersensitivity Vasculitis

Biological processes related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.46 C3 C4A CD79A MEFV
2 B cell proliferation GO:0042100 9.26 CD40LG CD79A
3 inflammatory response GO:0006954 9.02 C3 C4A CD40LG CRP MEFV
4 positive regulation of apoptotic cell clearance GO:2000427 8.96 C3 C4A

Molecular functions related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.96 C3 C4A
2 complement component C1q binding GO:0001849 8.62 C4A CRP

Sources for Hypersensitivity Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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