MCID: HYP263
MIFTS: 44

Hypersomnia malady

Mental diseases category
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Summaries for Hypersomnia

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44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Hypersomnia is characterized by recurrent episodes of excessive daytime sleepiness or prolonged nighttime sleep. Different from feeling tired due to lack of or interrupted sleep at night, persons with hypersomnia are compelled to nap repeatedly during the day, often at inappropriate times such as at work, during a meal, or in conversation. These daytime naps usually provide no relief from symptoms. Patients often have difficulty waking from a long sleep, and may feel disoriented. Other symptoms may include anxiety, increased irritation, decreased energy, restlessness, slow thinking, slow speech, loss of appetite, hallucinations, and memory difficulty. Some patients lose the ability to function in family, social, occupational, or other settings. Hypersomnia may be caused by another sleep disorder (such as narcolepsy or sleep apnea), dysfunction of the autonomic nervous system, or drug or alcohol abuse. In some cases it results from a physical problem, such as a tumor, head trauma, or injury to the central nervous system. Certain medications, or medicine withdrawal, may also cause hypersomnia. Medical conditions including multiple sclerosis, depression, encephalitis, epilepsy, or obesity may contribute to the disorder. Some people appear to have a genetic predisposition to hypersomnia; in others, there is no known cause. Typically, hypersomnia is first recognized in adolescence or young adulthood.

MalaCards: Hypersomnia is related to narcolepsy and sleep disorder. An important gene associated with Hypersomnia is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Cytokines and Inflammatory Response and Immune response NFAT in immune response. The compounds gamma-hydroxybutyrate and modafinil have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related mouse phenotypes are growth/size/body and behavior/neurological.

Wikipedia:65 In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders, published in May 2013,... more...

Aliases & Classifications for Hypersomnia

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44NINDS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

hypersomnia 44


Related Diseases for Hypersomnia

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17GeneCards, 18GeneDecks
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Diseases in the Recurrent Hypersomnia family:

hypersomnia

Diseases related to Hypersomnia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1narcolepsy31.3HCRT, HLA-DRB1
2sleep disorder30.5CHKB, HCRT
3prader-willi syndrome30.3HCRT, INS, GH1
4narcolepsy 130.1HCRT
5multiple sclerosis30.1HLA-DQB1, HLA-DRB1, CYP2D6, HCRT, TRA
6obesity29.9HCRT, INS, CPT1B, PARK2, GH1, CARTPT
7hypothyroidism29.8GH1, CHKB, INS
8recurrent hypersomnia10.6
9sleep apnea10.5
10kleine-levin syndrome10.5
11idiopathic hypersomnolence10.4
12idiopathic hypersomnia without long sleep time10.4
13myotonic dystrophy10.3
14major depressive disorder10.2
15neuronitis10.2
16obstructive sleep apnea10.1
17acromegaly10.1
18acute disseminated encephalomyelitis10.1
19encephalomyelitis10.1
20brain injury10.1
21traumatic brain injury10.1
22insomnia10.1
23idiopathic hypersomnia with long sleep time10.1
24phenylketonuria10.1SPR
25laron syndrome10.1GH1
26focal dystonia10.1PARK2
27pick's disease10.1CHKB
28craniopharyngioma10.1GH1, HCRT
29neuroleptic malignant syndrome10.1CYP2D6, CHKB
30rabson-mendenhall syndrome10.1INS
31multiple sclerosis 110.1HLA-DQB1, HLA-DRB1
32progressive supranuclear palsy10.1HCRT, PARK2
33parkinson's disease10.1PARK2, CYP2D6
34leprosy10.1HLA-DRB1
35eating disorder10.1INS
36encephalitis10.1
37mood disorder10.1
38myoclonus10.1
39morbid obesity10.0INS
40tauopathy10.0PPP2R4, PARK2
41lewy body dementia10.0PARK2, CYP2D6
42dilated cardiomyopathy10.0HLA-DQB1, HLA-DRB1, CHKB
43autoimmune hepatitis10.0CYP2D6, HLA-DRB1, HLA-DQB1
44dementia10.0PARK2, HCRT, CYP2D6
45hepatitis c10.0CYP2D6, HLA-DRB1, PPP2R4
46pituitary gland disease10.0GH1, INS
47growth hormone deficiency10.0INS, GH1
48movement disease10.0CYP2D6, PARK2
49hypopituitarism10.0INS, GH1
50systemic lupus erythematosus10.0TRA, CYP2D6, HLA-DRB1, HLA-DQB1

Graphical network of the top 20 diseases related to Hypersomnia:



Diseases related to hypersomnia

Symptoms for Hypersomnia

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Drugs & Therapeutics for Hypersomnia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Hypersomnia

Search NIH Clinical Center for Hypersomnia

Genetic Tests for Hypersomnia

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Anatomical Context for Hypersomnia

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33MalaCards
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MalaCards organs/tissues related to Hypersomnia:

33
Testes, Brain, Eye, Hypothalamus, Thalamus, Pituitary

Animal Models for Hypersomnia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypersomnia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1GH1, PARK2, INS, HCRT, HLA-DQB1, SPRED1
2MP:00053867.9CARTPT, SPR, SPRED1, HLA-DQB1, HCRT, INS
3MP:00036317.7GH1, CHKB, PARK2, INS, HCRT, HLA-DQB1
4MP:00053767.6SPR, HLA-DQB1, HCRT, INS, CPT1B, PARK2

Publications for Hypersomnia

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52PubMed
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Articles related to Hypersomnia:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Polysomnographic study of nocturnal sleep in idiopathic hypersomnia without long sleep time. (23061443)
2013
2
Left temporopolar impairment in a case of posttraumatic hypersomnia. (23407426)
2013
3
Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. (23646285)
2013
4
Case 16-2013: A girl with irritability, hypersomnia, and somatic symptoms. (24047075)
2013
5
Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience. (24306133)
2013
6
Recurrent hypersomnia due to occult hepatic encephalopathy. (22154356)
2012
7
Whipple's disease presenting with segmental myoclonus and hypersomnia. (22976777)
2012
8
Clarithromycin-induced hypersomnia in children. (21543032)
2011
9
The pathophysiologic basis of secondary narcolepsy and hypersomnia. (21298561)
2011
10
Recurrent hypersomnia: a review of 339 cases. (20970360)
2011
11
Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. (19927159)
2010
12
Non-convulsive status epilepticus presenting as recurrent hypersomnia. (20463123)
2010
13
Insulinoma presenting as idiopathic hypersomnia. (20119740)
2010
14
Neurosarcoidosis presenting as spontaneously remitting hypersomnia. (19609590)
2009
15
Idiopathic hypersomnia: clinical features and response to treatment. (20465024)
2009
16
Diagnostic pitfalls in children with sleep disorders: two cases with hypersomnia. (18754824)
2008
17
Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats. (17853446)
2007
18
Narcolepsy, metabolic syndrome and obstructive sleep apnea syndrome as the causes of hypersomnia in children. Report of three cases. (18229667)
2007
19
Episodic hypersomnia and unusual behaviors in a 14-year old adolescent. (18091094)
2007
20
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder. (16854470)
2006
21
Sleeping in? The impact of age and depressive sub-type on hypersomnia. (16325918)
2006
22
Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. (16006155)
2005
23
Hypersomnia associated with bilateral posterior hypothalamic lesion. A polysomnographic case study. (12646762)
2003
24
Sleep and EEG power spectrum in post encephalitis hypersomnia: a case report. (14592236)
2002
25
Is dawn simulation effective in ameliorating the difficulty awakening in seasonal affective disorder associated with hypersomnia? (12103471)
2002
26
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. (12374492)
2002
27
Hypersomnia in MS. (12499505)
2002
28
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. (11477286)
2001
29
Law of denervation and spinal mechanism of leg movements in sleep. Commentary on controversies in sleep medicineMontplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopamineergic mechanism. (11438257)
2001
30
Multiple sleep latency test and polysomnography in diagnosing Kleine-Levin syndrome and periodic hypersomnia. (11085556)
2000
31
Hypersomnia after tegmental pontine hematoma: case report. (7756013)
1995
32
Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia: a study of two unrelated Italian cases. (8256576)
1993
33
Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome. (1963255)
1990
34
Hypersomnia, bithalamic lesions, and altered sleep architecture in Kearns-Sayre syndrome. (3982647)
1985
35
Cerebrospinal fluid monoamine metabolites in narcolepsy and hypersomnia. (6189447)
1983
36
Effects of expiratory positive airway pressure on sleep-induced respiratory abnormalities in patients with hypersomnia-sleep apnea syndrome. (6354028)
1983
37
Hypersomnia: diagnosis and management. (6872490)
1983
38
Narcolepsy and idiopthic hypersomnia: biogenic amines and related compounds in CSF. (6890168)
1982
39
Hypersomnia associated with alveolar hypoventilation in myotonic dystrophy. (7202141)
1981
40
Lithium prophylaxis of periodic hypersomnia. (843779)
1977
41
Periodic megaphagia and hypersomnia--an example of the Kleine-Levin syndrome in an adolescent girl. (4719411)
1973
42
Micrognathia, hypersomnia and periodic breathing. (4657867)
1972
43
Diagnosis and dramatic cure in two patients suffering from severe diurnal hypersomnia. (4191233)
1970
44
Hypersomnia and car driving. (4097446)
1970
45
REM sleep and NREM sleep in narcolepsy and hypersomnia. (4183371)
1969
46
Hypersomnia. A discussion of psychiatric implications based on three cases. (5636091)
1968
47
Psychopathological investigation of a case of periodic hypersomnia and Bulimia (Kleine-Levin syndrome). (5235707)
1967
48
The Kleine-Levin syndrome: hypersomnia, bulimia, and abnormal mental states. (13896459)
1962
49
Multiple Angiolipomata and Hypersomnia. (19993785)
1951
50
A case of periodic hypersomnia. (14895817)
1951

Variations for Hypersomnia

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Expression for genes affiliated with Hypersomnia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersomnia

Search GEO for disease gene expression data for Hypersomnia.

Pathways for genes affiliated with Hypersomnia

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome
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Pathways related to Hypersomnia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HLA-DRB1, TRA
2
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.2HLA-DQB1, HLA-DRB1, TRA
3
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.2HLA-DQB1, HLA-DRB1, TRA
4
Show member pathways
9.0PPP2R4, HLA-DQB1, HLA-DRB1

Compounds for genes affiliated with Hypersomnia

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Hypersomnia according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1gamma-hydroxybutyrate4510.3CHKB, HCRT
2modafinil45 51 1112.3CYP2D6, HCRT
3methylphenidate45 51 1112.2HCRT, CYP2D6
4amphetamine45 51 1112.1CARTPT, HCRT, CYP2D6
5oxandrolone45 1111.1INS, GH1
6phenformin45 1111.1INS, CYP2D6
7acipimox45 2911.0GH1, INS
8nateglinide45 51 1112.0CYP2D6, INS
9carnitine459.9CHKB, INS, CPT1B
10beta-hydroxybutyrate459.9INS, GH1, CHKB
11cocaine45 1110.9CHKB, HCRT, CARTPT, CYP2D6
12intralipid459.9INS, GH1
13catecholamine459.9HCRT, PARK2, CHKB
14olanzapine45 51 29 24 1113.9CYP2D6, INS, CHKB
15dextromethorphan3 51 24 1112.9TAS2R1, CYP2D6
16androstenedione45 2410.8INS, CYP2D6, GH1
171 methyl 4 phenylpyridinium459.8CYP2D6, PARK2
18cortisone45 2410.7INS, GH1
19rosiglitazone29 45 51 24 1113.7CYP2D6, INS, GH1
20bamhi459.7TRA, HLA-DQB1
21thyroxine45 2410.7INS, HCRT, GH1, CHKB
22estradiol45 24 1111.7GH1, CYP2D6, HCRT, CHKB
23epinephrine45 24 1111.7CHKB, HCRT, INS, GH1
24glycerol45 24 1111.7CHKB, INS, CPT1B, GH1
25clomiphene citrate459.6INS, GH1
26c-peptide459.6HCRT, HLA-DRB1, GH1, INS
27levodopa45 1110.6GH1, PARK2, CHKB, CYP2D6
28norepinephrine45 24 1111.5SPR, HCRT, CHKB, INS, GH1
29doxazosin45 1110.5INS, CYP2D6
30fatty acid459.4INS, CHKB, CYP2D6, CPT1B, GH1
31nitric oxide45 24 1111.4HCRT, SPR, CYP2D6, CHKB, PARK2
32melatonin45 29 61 24 1113.3PPP2R4, HCRT, GH1, SPR
33dexamethasone45 51 29 1112.3CYP2D6, HCRT, INS, GH1, CHKB
34gnrh459.1HCRT, INS, GH1, PPP2R4
35cholesterol45 29 24 1111.9CYP2D6, PPP2R4, HCRT, INS, CHKB
36lysine458.9CHKB, PPP2R4, HLA-DRB1, PARK2
37glutamine458.7CHKB, PARK2, HLA-DQB1, GH1, PPP2R4
38glycogen45 249.7CHKB, PPP2R4, INS, CPT1B, PARK2
39arginine458.6PPP2R4, CHKB, INS, GH1, HLA-DRB1
40leucine458.6PPP2R4, CHKB, GH1, PARK2
41glutamate458.6HLA-DRB1, PPP2R4, CHKB, INS, HCRT, HLA-DQB1
42atp45 299.5HLA-DRB1, PPP2R4, HCRT, CHKB, PARK2
43oligonucleotide458.5GH1, PPP2R4, HLA-DRB1, HCRT, PARK2, HLA-DQB1
44estrogen458.4INS, HCRT, PARK2, CHKB, GH1, PPP2R4
45glucose458.2CPT1B, INS, PARK2, CHKB, GH1, HCRT
46testosterone45 61 24 1111.2PARK2, PPP2R4, CYP2D6, HCRT, INS, CHKB
47lipid458.2GH1, CYP2D6, PPP2R4, CPT1B, INS, PARK2
48dopamine45 29 24 1111.1CYP2D6, PPP2R4, SPR, CARTPT, HCRT, PARK2
49alanine458.1GH1, CHKB, PARK2, INS, HLA-DRB1, HCRT
50tyrosine457.6GH1, PARK2, INS, PPP2R4, SPR, HLA-DQB1

GO Terms for genes affiliated with Hypersomnia

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16Gene Ontology
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Cellular components related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:0306699.8HLA-DRB1, HLA-DQB1
2MHC class II protein complexGO:0426139.7HLA-DRB1, HLA-DQB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.5HLA-DRB1, HLA-DQB1

Biological processes related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transmission of nerve impulseGO:05197110.0CARTPT, HCRT
2humoral immune response mediated by circulating immunoglobulinGO:0024559.8HLA-DRB1, HLA-DQB1
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.5HLA-DRB1, HLA-DQB1

Molecular functions related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.8HLA-DRB1, HLA-DQB1

Products for genes affiliated with Hypersomnia

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Sources for Hypersomnia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet