MCID: HYP263
MIFTS: 39

Hypersomnia malady

Summaries for Hypersomnia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Hypersomnia is characterized by recurrent episodes of excessive daytime sleepiness or prolonged nighttime sleep. Different from feeling tired due to lack of or interrupted sleep at night, persons with hypersomnia are compelled to nap repeatedly during the day, often at inappropriate times such as at work, during a meal, or in conversation. These daytime naps usually provide no relief from symptoms. Patients often have difficulty waking from a long sleep, and may feel disoriented. Other symptoms may include anxiety, increased irritation, decreased energy, restlessness, slow thinking, slow speech, loss of appetite, hallucinations, and memory difficulty. Some patients lose the ability to function in family, social, occupational, or other settings. Hypersomnia may be caused by another sleep disorder (such as narcolepsy or sleep apnea), dysfunction of the autonomic nervous system, or drug or alcohol abuse. In some cases it results from a physical problem, such as a tumor, head trauma, or injury to the central nervous system. Certain medications, or medicine withdrawal, may also cause hypersomnia. Medical conditions including multiple sclerosis, depression, encephalitis, epilepsy, or obesity may contribute to the disorder. Some people appear to have a genetic predisposition to hypersomnia; in others, there is no known cause. Typically, hypersomnia is first recognized in adolescence or young adulthood.

MalaCards: Hypersomnia is related to narcolepsy and kleine-levin syndrome. An important gene associated with Hypersomnia is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are G-protein signaling N-RAS regulation pathway and Immune response T cell receptor signaling pathway. The compounds norepinephrine and modafinil have been mentioned in the context of this disorder. Affiliated tissues include brain, thalamus and hypothalamus, and related mouse phenotypes are nervous system and growth/size.

Wikipedia:64 The term hypersomnia refers to a large group of disorders characterized by excessive daytime sleepiness... more...

Aliases & Classifications for Hypersomnia

Sources:
44NINDS
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Aliases & Descriptions:

hypersomnia 44


Related Diseases for Hypersomnia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the recurrent hypersomnia family:

hypersomnia

Diseases related to Hypersomnia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1narcolepsy31.1HCRT, HLA-DRB1
2kleine-levin syndrome30.7RPS6KB2
3sleep disorder30.6CHKB, HCRT
4sleep apnea10.5
5idiopathic hypersomnolence10.4
6n syndrome10.3
7major depressive disorder10.2
8prader-willi syndrome10.2
9acute disseminated encephalomyelitis10.1
10brain injury10.1
11traumatic brain injury10.1
12insomnia10.1
13narcolepsy 110.1
14acromegaly10.0
15whipple disease10.0
16adult syndrome10.0
17myoclonus10.0
18idiopathic hypersomnia without long sleep time10.0
19idiopathic hypersomnia with long sleep time10.0
20deficiency anemia10.0CHKB
21myositis10.0CHKB
22myasthenia gravis10.0HLA-DQB1
23addison's disease10.0CYP2D6
24guillain-barre syndrome10.0HCRT
25dermatomyositis10.0CHKB
26diabetic ketoacidosis10.0INS
27liver cirrhosis10.0HLA-DRB1
28eating disorder10.0INS
29lung cancer10.0CYP2D6
30blindness10.0INS
31mental retardation10.0PARK2
32acquired immunodeficiency syndrome10.0CARTPT
33hypertension10.0INS
34rabson-mendenhall syndrome10.0INS
35hypoadrenalism10.0GH1
36focal dystonia10.0PARK2
37metabolic acidosis10.0CHKB
38thalassemia10.0BCL11A
39duodenal ulcer10.0INS
40migraine10.0CYP2D6, HCRT
41myotonic dystrophy10.0HCRT, CHKB
42anorexia nervosa10.0GH1, HCRT
43celiac disease10.0HLA-DQB1
44pancreatitis10.0INS
45adenocarcinoma10.0RPS6KB2, CYP2D6
46graves' disease10.0HLA-DRB1, HLA-DQB1
47multiple sclerosis10.0HLA-DRB1, HLA-DQB1
48multiple system atrophy10.0PARK2, CYP2D6
49craniopharyngioma10.0HCRT, GH1
50essential hypertension10.0CYP2D6, INS

Graphical network of the top 20 diseases related to Hypersomnia:



Diseases related to hypersomnia

Clinical Features for Hypersomnia

Drugs & Therapeutics for Hypersomnia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypersomnia

Drug clinical trials:

Search ClinicalTrials for Hypersomnia

Search NIH Clinical Center for Hypersomnia

Search CenterWatch for Hypersomnia

Genetic Tests for Hypersomnia

Anatomical Context for Hypersomnia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypersomnia:

33
Brain, Thalamus, Hypothalamus, Pituitary

Animal Models for Hypersomnia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hypersomnia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.3HLA-DQB1, GH1, CHKB, HCRT, INS, SPR
2MP:00053788.0CARTPT, HLA-DQB1, GH1, HCRT, INS, PARK2
3MP:00053767.5CPT1B, RPS6KB2, CARTPT, HLA-DQB1, GH1, CHKB

Publications for Hypersomnia

Sources:
51PubMed
See all sources

Articles related to Hypersomnia:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
Differences in findings of nocturnal polysomnography and multiple sleep latency test between narcolepsy and idiopathic hypersomnia. (21723190)
2012
2
Clarithromycin-induced hypersomnia in children. (21543032)
2011
3
Benefit and risk of modafinil in idiopathic hypersomnia vs. narcolepsy with cataplexy. (21576035)
2011
4
Narcoleptic-like hypersomnia and inverted circadian rhythm of body core temperature after traumatic brain injury involving the hypothalamus. (22033119)
2011
5
Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. (19927159)
2010
6
Non-convulsive status epilepticus presenting as recurrent hypersomnia. (20463123)
2010
7
The socio-economical burden of hypersomnia. (20047573)
2010
8
CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome. (19238805)
2009
9
Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations. (19672985)
2009
10
Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia? (19238797)
2009
11
Prevalence of the HLA-DQB1*0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit in SALo Paulo. (19506770)
2009
12
Narcolepsy and other hypersomnias in children. (19023917)
2008
13
CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in Norway. (17702265)
2007
14
Hypersomnia following traumatic brain injury. (17694724)
2007
15
Idiopathic hypersomnia: a study of 77 cases. (17969461)
2007
16
Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. (16006155)
2005
17
Hypersomnia caused by isolated angiitis of the CNS. (16157993)
2005
18
Hypersomnia and low cerebrospinal fluid hypocretin levels in acute disseminated encephalomyelitis. (15519122)
2004
19
Idiopathic Hypersomnia. (12530998)
2001
20
Commentary on controversies in sleep medicine. Montplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopaminergic mechanism. (11438258)
2001
21
Multiple sleep latency test and polysomnography in diagnosing Kleine-Levin syndrome and periodic hypersomnia. (11085556)
2000
22
Hypersomnia in Wilson's disease: an unusual symptom in an unusual case. (10770529)
2000
23
Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study. (11022396)
2000
24
Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test. (10459716)
1999
25
Periodic hypersomnia. (11273331)
1998
26
Measurement of P300 and sleep characteristics in patients with hypersomnia: do P300 latencies, P300 amplitudes, and multiple sleep latency and maintenance of wakefulness tests measure different factors? (9241473)
1997
27
Hypersomnia in association with dysthymia in comparison with idiopathic hypersomnia and normal controls. (8739385)
1996
28
Hypersomnia following paramedian thalamic stroke: a report of 12 patients. (8619525)
1996
29
Myotonic dystrophy with alveolar hypoventilation and hypersomnia: a clinicopathological study. (7738599)
1995
30
Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. (8726119)
1995
31
P300 latency: abnormal in sleep apnea with somnolence and idiopathic hypersomnia, but normal in narcolepsy. (7554301)
1995
32
Menstrual-associated sleep disorder: an unusual hypersomniac variant associated with both menstruation and amenorrhea with a possible link to prolactin and metoclopramide. (8378689)
1993
33
Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. (2906157)
1988
34
Phase delay and hypersomnia. (3963263)
1986
35
Hypersomnia, bithalamic lesions, and altered sleep architecture in Kearns-Sayre syndrome. (3982647)
1985
36
Marked episodic elevation of cerebrospinal fluid pressure during nocturnal sleep in patients with sleep apnea hypersomnia syndrome. (2578929)
1985
37
Hypersomnia in major depressive disorders. (6235259)
1984
38
Effects of expiratory positive airway pressure on sleep-induced respiratory abnormalities in patients with hypersomnia-sleep apnea syndrome. (6354028)
1983
39
An electroencephalographic and polygraphic study of narcolepsy and hypersomnia. (6956508)
1982
40
Abnormal central monoamine metabolism in humans with "true hypersomnia" and "sub-wakefulness". (323018)
1977
41
Letter: Hypersomnia and MAOI antidepressants. (4852814)
1974
42
Micrognathia, hypersomnia and periodic breathing. (4657867)
1972
43
Continuous recording of the pulmonary and systemic arterial pressure during sleep in syndromes of hypersomnia with periodic breathing. (4348639)
1972
44
Pathophysiological mechanisms of narcolepsy, hypersomnia and dissociated sleep disturbances. (4183393)
1969
45
The EEG in a case of periodic hypersomnia. (4188786)
1969
46
Hypersomnia. A discussion of psychiatric implications based on three cases. (5636091)
1968
47
Particular clinical and polygraphic aspects of hypersomnia in the course of mesencephalic lesion. (4182640)
1968
48
Hypersomnia in dystrophia myotonica. (13735243)
1961
49
Preliminary trial of a new stimulant SCH 5472 in ambulatory patients with depression, exhaustion, or hypersomnia syndrome. (13729397)
1960
50
Comments and observations on psychogenic hypersomnia. (13582299)
1958

Genetic Variations for Hypersomnia

Expression for genes affiliated with Hypersomnia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypersomnia

Search GEO for disease gene expression data for Hypersomnia.

Pathways for genes affiliated with Hypersomnia

Sources:
12EMD Millipore, 54Reactome, 52QIAGEN
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Pathways related to Hypersomnia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-DQB1, HLA-DRB1, TRA
29.3HLA-DQB1, HLA-DRB1, TRA
3
Immune response NFAT in immune response
Hide members
9.3TRA, HLA-DRB1, HLA-DQB1
49.3TRA, HLA-DRB1, HLA-DQB1
5
Immune response ICOS pathway in T-helper cell
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9.3TRA, HLA-DRB1, HLA-DQB1
6
Immune response Antigen presentation by MHC class II
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9.3TRA, HLA-DRB1, HLA-DQB1
7
Hide members
9.1PPP2R4, HLA-DQB1, HLA-DRB1

Compounds for genes affiliated with Hypersomnia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Hypersomnia according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.2CHKB, HCRT, SPR
2modafinil45 50 1112.2CYP2D6, HCRT
3oxandrolone45 1111.2INS, GH1
4phenformin45 1111.1INS, CYP2D6
5beta-hydroxybutyrate4510.1INS, CHKB, GH1
6gamma-hydroxybutyrate4510.1HCRT, CHKB
7methylphenidate45 50 1112.0CYP2D6, HCRT
8amphetamine45 1111.0CYP2D6, HCRT, CARTPT
9olanzapine50 45 29 11 2414.0INS, CYP2D6, CHKB
10carnitine459.9CPT1B, INS, CHKB
11androstenedione45 2410.8GH1, CYP2D6, INS
12cocaine45 1110.8CYP2D6, HCRT, CHKB, CARTPT
13thyroxine45 2410.8GH1, CHKB, HCRT, INS
14catecholamine459.8PARK2, HCRT, CHKB
15levodopa45 1110.8PARK2, CYP2D6, CHKB, GH1
16c-peptide459.8HLA-DRB1, GH1, HCRT, INS
17glycerol45 11 2411.8CPT1B, INS, CHKB, GH1
18epinephrine45 11 2411.7GH1, CHKB, HCRT, INS
19dextromethorphan2 50 11 2412.6CYP2D6, TAS2R1
20glucose459.6PPP2R4, CHKB, HCRT
21fatty acid459.5GH1, CHKB, CYP2D6, INS, CPT1B
22melatonin45 60 29 11 2413.4PPP2R4, GH1, HCRT, SPR
23gnrh459.2PPP2R4, GH1, HCRT, INS
24glutamine459.0PPP2R4, HLA-DQB1, GH1, CHKB, PARK2
25glycogen45 2410.0CPT1B, PARK2, INS, CHKB, PPP2R4
26cholesterol45 29 11 2411.8PPP2R4, CHKB, HCRT, CYP2D6, INS
27oligonucleotide458.7PPP2R4, HLA-DQB1, HLA-DRB1, GH1, HCRT, PARK2
28glutamate458.7PPP2R4, HLA-DQB1, HLA-DRB1, CHKB, HCRT, INS
29wortmannin458.6INS, GH1, PPP2R4, RPS6KB2
30estrogen458.6PPP2R4, GH1, CHKB, HCRT, INS, PARK2
31testosterone45 60 11 2411.5PPP2R4, GH1, CHKB, HCRT, CYP2D6, INS
32alanine458.4PPP2R4, HLA-DRB1, GH1, CHKB, HCRT, INS
33lipid458.4PPP2R4, GH1, HCRT, CYP2D6, INS, PARK2
34dopamine45 29 11 2411.3SPR, CARTPT, PPP2R4, GH1, CHKB, HCRT
35tyrosine458.0PPP2R4, HLA-DQB1, HLA-DRB1, GH1, HCRT, CYP2D6

GO Terms for genes affiliated with Hypersomnia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.0HLA-DRB1, HLA-DQB1

Biological processes related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune response mediated by circulating immunoglobulinGO:00245510.0HLA-DRB1, HLA-DQB1
2positive regulation of transmission of nerve impulseGO:0519719.8HCRT, CARTPT
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.7HLA-DRB1, HLA-DQB1

Molecular functions related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.0HLA-DRB1, HLA-DQB1

Products for genes affiliated with Hypersomnia

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Sources for Hypersomnia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet