MCID: HYP263
MIFTS: 45

Hypersomnia malady

Mental diseases category
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Summaries for Hypersomnia

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NINDS:43 Hypersomnia is characterized by recurrent episodes of excessive daytime sleepiness or prolonged nighttime sleep. Different from feeling tired due to lack of or interrupted sleep at night, persons with hypersomnia are compelled to nap repeatedly during the day, often at inappropriate times such as at work, during a meal, or in conversation. These daytime naps usually provide no relief from symptoms. Patients often have difficulty waking from a long sleep, and may feel disoriented. Other symptoms may include anxiety, increased irritation, decreased energy, restlessness, slow thinking, slow speech, loss of appetite, hallucinations, and memory difficulty. Some patients lose the ability to function in family, social, occupational, or other settings. Hypersomnia may be caused by another sleep disorder (such as narcolepsy or sleep apnea), dysfunction of the autonomic nervous system, or drug or alcohol abuse. In some cases it results from a physical problem, such as a tumor, head trauma, or injury to the central nervous system. Certain medications, or medicine withdrawal, may also cause hypersomnia. Medical conditions including multiple sclerosis, depression, encephalitis, epilepsy, or obesity may contribute to the disorder. Some people appear to have a genetic predisposition to hypersomnia; in others, there is no known cause. Typically, hypersomnia is first recognized in adolescence or young adulthood.

MalaCards based summary: Hypersomnia is related to narcolepsy and sleep disorder. An important gene associated with Hypersomnia is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Cytokines and Inflammatory Response and Immune response NFAT in immune response. The compounds gamma-hydroxybutyrate and modafinil have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related mouse phenotypes are growth/size/body and behavior/neurological.

Wikipedia:65 In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders, published in May 2013,... more...

Aliases & Classifications for Hypersomnia

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Hypersomnia, Aliases & Descriptions:

Name: Hypersomnia 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Related Diseases for Hypersomnia

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Diseases in the Recurrent Hypersomnia family:

hypersomnia

Diseases related to Hypersomnia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1narcolepsy31.7HLA-DRB1, HCRT
2sleep disorder31.1CHKB, HCRT
3narcolepsy 130.7HCRT
4prader-willi syndrome30.4INS, HCRT, GH1
5multiple sclerosis30.0TRA, HCRT, CYP2D6, HLA-DRB1, HLA-DQB1
6hypothyroidism29.8CHKB, GH1, INS
7obesity29.5GH1, PARK2, INS, CPT1B, HCRT, CARTPT
8recurrent hypersomnia10.6
9sleep apnea10.5
10phenylketonuria10.5SPR
11kleine-levin syndrome10.5
12idiopathic hypersomnolence10.5
13laron syndrome10.4GH1
14focal dystonia10.4PARK2
15idiopathic hypersomnia without long sleep time10.4
16pick's disease10.4CHKB
17craniopharyngioma10.3HCRT, GH1
18myotonic dystrophy10.3
19neuroleptic malignant syndrome10.3CHKB, CYP2D6
20rabson-mendenhall syndrome10.3INS
21multiple sclerosis 110.3HLA-DRB1, HLA-DQB1
22progressive supranuclear palsy10.3PARK2, HCRT
23parkinson's disease10.3PARK2, CYP2D6
24eating disorder10.3INS
25leprosy10.2HLA-DRB1
26major depressive disorder10.2
27neuronitis10.2
28idiopathic hypersomnia with long sleep time10.2
29morbid obesity10.2INS
30tauopathy10.2PPP2R4, PARK2
31lewy body dementia10.2CYP2D6, PARK2
32brain injury10.2
33traumatic brain injury10.2
34acromegaly10.2
35obstructive sleep apnea10.2
36acute disseminated encephalomyelitis10.2
37encephalitis10.2
38blindness10.2
39dilated cardiomyopathy10.1HLA-DQB1, HLA-DRB1, CHKB
40autoimmune hepatitis10.1HLA-DQB1, CYP2D6, HLA-DRB1
41dementia10.1CYP2D6, HCRT, PARK2
42hepatitis c10.1HLA-DRB1, PPP2R4, CYP2D6
43pituitary gland disease10.1INS, GH1
44mood disorder10.1
45myoclonus10.1
46juvenile rheumatoid arthritis10.1HLA-DRB1, HLA-DQB1
47growth hormone deficiency10.0INS, GH1
48hypopituitarism10.0INS, GH1
49systemic lupus erythematosus10.0TRA, HLA-DQB1, CYP2D6, HLA-DRB1
50ulcerative colitis10.0TRA, HLA-DRB1, CHKB

Graphical network of the top 20 diseases related to Hypersomnia:



Diseases related to hypersomnia

Symptoms for Hypersomnia

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Drugs & Therapeutics for Hypersomnia

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Drug clinical trials:

Search ClinicalTrials for Hypersomnia

Search NIH Clinical Center for Hypersomnia

Genetic Tests for Hypersomnia

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Anatomical Context for Hypersomnia

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MalaCards organs/tissues related to Hypersomnia:

32
Testes, Brain, Eye, Hypothalamus, Thalamus, Pituitary

Animal Models for Hypersomnia or affiliated genes

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MGI Mouse Phenotypes related to Hypersomnia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1GH1, PARK2, INS, HCRT, HLA-DQB1, SPRED1
2MP:00053867.9CARTPT, SPR, SPRED1, HLA-DQB1, HCRT, INS
3MP:00036317.7GH1, CHKB, PARK2, INS, HCRT, HLA-DQB1
4MP:00053767.6SPR, HLA-DQB1, HCRT, INS, CPT1B, PARK2

Publications for Hypersomnia

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Articles related to Hypersomnia:

(show top 50)    (show all 299)
idTitleAuthorsYear
1
Sleepiness and Performance Is Disproportionate in Patients with Non-Organic Hypersomnia in Comparison to Patients with Narcolepsy and Mild to Moderate Obstructive Sleep Apnoea. (25377356)
2014
2
Modafinil in the treatment of idiopathic hypersomnia without long sleep time-a randomized, double-blind, placebo-controlled study. (25196321)
2014
3
Use of subcutaneous flumazenil preparations for the treatment of idiopathic hypersomnia: A case report. (24554692)
2014
4
Left temporopolar impairment in a case of posttraumatic hypersomnia. (23407426)
2013
5
Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. (23646285)
2013
6
Case 16-2013: A girl with irritability, hypersomnia, and somatic symptoms. (24047075)
2013
7
Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience. (24306133)
2013
8
Recurrent hypersomnia due to occult hepatic encephalopathy. (22154356)
2012
9
Clarithromycin-induced hypersomnia in children. (21543032)
2011
10
The pathophysiologic basis of secondary narcolepsy and hypersomnia. (21298561)
2011
11
Recurrent hypersomnia: a review of 339 cases. (20970360)
2011
12
Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. (19927159)
2010
13
Non-convulsive status epilepticus presenting as recurrent hypersomnia. (20463123)
2010
14
Neurosarcoidosis presenting as spontaneously remitting hypersomnia. (19609590)
2009
15
Idiopathic hypersomnia: clinical features and response to treatment. (20465024)
2009
16
Diagnostic pitfalls in children with sleep disorders: two cases with hypersomnia. (18754824)
2008
17
Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats. (17853446)
2007
18
Narcolepsy, metabolic syndrome and obstructive sleep apnea syndrome as the causes of hypersomnia in children. Report of three cases. (18229667)
2007
19
Episodic hypersomnia and unusual behaviors in a 14-year old adolescent. (18091094)
2007
20
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder. (16854470)
2006
21
Sleeping in? The impact of age and depressive sub-type on hypersomnia. (16325918)
2006
22
Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. (16006155)
2005
23
Hypersomnia associated with bilateral posterior hypothalamic lesion. A polysomnographic case study. (12646762)
2003
24
Sleep and EEG power spectrum in post encephalitis hypersomnia: a case report. (14592236)
2002
25
Is dawn simulation effective in ameliorating the difficulty awakening in seasonal affective disorder associated with hypersomnia? (12103471)
2002
26
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. (12374492)
2002
27
Hypersomnia in MS. (12499505)
2002
28
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. (11477286)
2001
29
Law of denervation and spinal mechanism of leg movements in sleep. Commentary on controversies in sleep medicineMontplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopamineergic mechanism. (11438257)
2001
30
Multiple sleep latency test and polysomnography in diagnosing Kleine-Levin syndrome and periodic hypersomnia. (11085556)
2000
31
Hypersomnia after tegmental pontine hematoma: case report. (7756013)
1995
32
Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia: a study of two unrelated Italian cases. (8256576)
1993
33
Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome. (1963255)
1990
34
Hypersomnia, bithalamic lesions, and altered sleep architecture in Kearns-Sayre syndrome. (3982647)
1985
35
Cerebrospinal fluid monoamine metabolites in narcolepsy and hypersomnia. (6189447)
1983
36
Effects of expiratory positive airway pressure on sleep-induced respiratory abnormalities in patients with hypersomnia-sleep apnea syndrome. (6354028)
1983
37
Hypersomnia: diagnosis and management. (6872490)
1983
38
Narcolepsy and idiopthic hypersomnia: biogenic amines and related compounds in CSF. (6890168)
1982
39
Hypersomnia associated with alveolar hypoventilation in myotonic dystrophy. (7202141)
1981
40
Lithium prophylaxis of periodic hypersomnia. (843779)
1977
41
Periodic megaphagia and hypersomnia--an example of the Kleine-Levin syndrome in an adolescent girl. (4719411)
1973
42
Micrognathia, hypersomnia and periodic breathing. (4657867)
1972
43
Diagnosis and dramatic cure in two patients suffering from severe diurnal hypersomnia. (4191233)
1970
44
Hypersomnia and car driving. (4097446)
1970
45
REM sleep and NREM sleep in narcolepsy and hypersomnia. (4183371)
1969
46
Hypersomnia. A discussion of psychiatric implications based on three cases. (5636091)
1968
47
Psychopathological investigation of a case of periodic hypersomnia and Bulimia (Kleine-Levin syndrome). (5235707)
1967
48
The Kleine-Levin syndrome: hypersomnia, bulimia, and abnormal mental states. (13896459)
1962
49
Multiple Angiolipomata and Hypersomnia. (19993785)
1951
50
A case of periodic hypersomnia. (14895817)
1951

Variations for Hypersomnia

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Expression for genes affiliated with Hypersomnia

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Expression patterns in normal tissues for genes affiliated with Hypersomnia

Search GEO for disease gene expression data for Hypersomnia.

Pathways for genes affiliated with Hypersomnia

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Pathways related to Hypersomnia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HLA-DRB1, TRA
2
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.2HLA-DQB1, HLA-DRB1, TRA
3
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.2HLA-DQB1, HLA-DRB1, TRA
4
Show member pathways
9.0PPP2R4, HLA-DQB1, HLA-DRB1

Compounds for genes affiliated with Hypersomnia

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Compounds related to Hypersomnia according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1gamma-hydroxybutyrate4410.3CHKB, HCRT
2modafinil44 50 1112.3CYP2D6, HCRT
3methylphenidate44 50 1112.2HCRT, CYP2D6
4amphetamine44 50 1112.1CARTPT, HCRT, CYP2D6
5oxandrolone44 1111.1INS, GH1
6phenformin44 1111.1INS, CYP2D6
7acipimox44 2811.0GH1, INS
8nateglinide44 50 1112.0CYP2D6, INS
9carnitine449.9CHKB, INS, CPT1B
10beta-hydroxybutyrate449.9INS, GH1, CHKB
11cocaine44 1110.9CHKB, HCRT, CARTPT, CYP2D6
12intralipid449.9INS, GH1
13catecholamine449.9HCRT, PARK2, CHKB
14olanzapine44 50 28 24 1113.9CYP2D6, INS, CHKB
15dextromethorphan2 50 24 1112.9TAS2R1, CYP2D6
16androstenedione44 2410.8INS, CYP2D6, GH1
171 methyl 4 phenylpyridinium449.8CYP2D6, PARK2
18cortisone44 2410.7INS, GH1
19rosiglitazone28 44 50 24 1113.7CYP2D6, INS, GH1
20bamhi449.7TRA, HLA-DQB1
21thyroxine44 2410.7INS, HCRT, GH1, CHKB
22estradiol44 24 1111.7GH1, CYP2D6, HCRT, CHKB
23epinephrine44 24 1111.7CHKB, HCRT, INS, GH1
24glycerol44 24 1111.7CHKB, INS, CPT1B, GH1
25clomiphene citrate449.6INS, GH1
26c-peptide449.6HCRT, HLA-DRB1, GH1, INS
27levodopa44 1110.6GH1, PARK2, CHKB, CYP2D6
28norepinephrine44 24 1111.5SPR, HCRT, CHKB, INS, GH1
29doxazosin44 1110.5INS, CYP2D6
30fatty acid449.4INS, CHKB, CYP2D6, CPT1B, GH1
31nitric oxide44 24 1111.4HCRT, SPR, CYP2D6, CHKB, PARK2
32melatonin44 28 61 24 1113.3PPP2R4, HCRT, GH1, SPR
33dexamethasone44 50 28 1112.3CYP2D6, HCRT, INS, GH1, CHKB
34gnrh449.1HCRT, INS, GH1, PPP2R4
35cholesterol44 28 24 1111.9CYP2D6, PPP2R4, HCRT, INS, CHKB
36lysine448.9CHKB, PPP2R4, HLA-DRB1, PARK2
37glutamine448.7CHKB, PARK2, HLA-DQB1, GH1, PPP2R4
38glycogen44 249.7CHKB, PPP2R4, INS, CPT1B, PARK2
39arginine448.6PPP2R4, CHKB, INS, GH1, HLA-DRB1
40leucine448.6PPP2R4, CHKB, GH1, PARK2
41glutamate448.6HLA-DRB1, PPP2R4, CHKB, INS, HCRT, HLA-DQB1
42atp44 289.5HLA-DRB1, PPP2R4, HCRT, CHKB, PARK2
43oligonucleotide448.5GH1, PPP2R4, HLA-DRB1, HCRT, PARK2, HLA-DQB1
44estrogen448.4INS, HCRT, PARK2, CHKB, GH1, PPP2R4
45glucose448.2CPT1B, INS, PARK2, CHKB, GH1, HCRT
46testosterone44 61 24 1111.2PARK2, PPP2R4, CYP2D6, HCRT, INS, CHKB
47lipid448.2GH1, CYP2D6, PPP2R4, CPT1B, INS, PARK2
48dopamine44 28 24 1111.1CYP2D6, PPP2R4, SPR, CARTPT, HCRT, PARK2
49alanine448.1GH1, CHKB, PARK2, INS, HLA-DRB1, HCRT
50tyrosine447.6GH1, PARK2, INS, PPP2R4, SPR, HLA-DQB1

GO Terms for genes affiliated with Hypersomnia

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Cellular components related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:0306699.8HLA-DRB1, HLA-DQB1
2MHC class II protein complexGO:0426139.7HLA-DRB1, HLA-DQB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.5HLA-DRB1, HLA-DQB1

Biological processes related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transmission of nerve impulseGO:05197110.0CARTPT, HCRT
2humoral immune response mediated by circulating immunoglobulinGO:0024559.8HLA-DRB1, HLA-DQB1
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.5HLA-DRB1, HLA-DQB1

Molecular functions related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.8HLA-DRB1, HLA-DQB1

Products for genes affiliated with Hypersomnia

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Sources for Hypersomnia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet