MCID: HYP263
MIFTS: 29

Hypersomnia malady

Summaries for Hypersomnia

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Hypersomnia is characterized by recurrent episodes of excessive daytime sleepiness or prolonged nighttime sleep. Different from feeling tired due to lack of or interrupted sleep at night, persons with hypersomnia are compelled to nap repeatedly during the day, often at inappropriate times such as at work, during a meal, or in conversation. These daytime naps usually provide no relief from symptoms. Patients often have difficulty waking from a long sleep, and may feel disoriented. Other symptoms may include anxiety, increased irritation, decreased energy, restlessness, slow thinking, slow speech, loss of appetite, hallucinations, and memory difficulty. Some patients lose the ability to function in family, social, occupational, or other settings. Hypersomnia may be caused by another sleep disorder (such as narcolepsy or sleep apnea), dysfunction of the autonomic nervous system, or drug or alcohol abuse. In some cases it results from a physical problem, such as a tumor, head trauma, or injury to the central nervous system. Certain medications, or medicine withdrawal, may also cause hypersomnia. Medical conditions including multiple sclerosis, depression, encephalitis, epilepsy, or obesity may contribute to the disorder. Some people appear to have a genetic predisposition to hypersomnia; in others, there is no known cause. Typically, hypersomnia is first recognized in adolescence or young adulthood.

MalaCards: Hypersomnia is related to narcolepsy and kleine-levin syndrome. An important gene associated with Hypersomnia is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are G-protein signaling N-RAS regulation pathway and Immune response T cell receptor signaling pathway. The compounds norepinephrine and modafinil have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are nervous system and growth/size.

Wikipedia:63 The term hypersomnia refers to a large group of disorders characterized by excessive daytime sleepiness... more...

Aliases & Classifications for Hypersomnia

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43NINDS
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Aliases & Descriptions:

hypersomnia 43


Related Diseases for Hypersomnia

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17GeneCards, 18GeneDecks
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Diseases in the Recurrent Hypersomnia family:

hypersomnia

Diseases related to Hypersomnia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1narcolepsy31.1HCRT, HLA-DRB1
2kleine-levin syndrome30.7RPS6KB2
3sleep disorder30.5CHKB, HCRT
4myotonic dystrophy30.4CHKB, HCRT
5multiple sclerosis30.0HLA-DQB1, HLA-DRB1
6obesity30.0CPT1B, GH1, CARTPT, HCRT, INS, PARK2
7migraine29.8CYP2D6, HCRT
8hypothyroidism29.8INS, CHKB, GH1
9recurrent hypersomnia10.5
10idiopathic hypersomnolence10.4
11major depressive disorder10.2
12neuronitis10.2
13prader-willi syndrome10.2
14acute disseminated encephalomyelitis10.1
15encephalomyelitis10.1
16idiopathic hypersomnia without long sleep time10.1
17idiopathic hypersomnia with long sleep time10.1
18acromegaly10.0
19adult syndrome10.0
20encephalitis10.0
21mood disorder10.0
22deficiency anemia10.0CHKB
23myositis10.0CHKB
24myasthenia gravis10.0HLA-DQB1
25addison's disease10.0CYP2D6
26guillain-barre syndrome10.0HCRT
27dermatomyositis10.0CHKB
28diabetic ketoacidosis10.0INS
29liver cirrhosis10.0HLA-DRB1
30eating disorder10.0INS
31lung cancer10.0CYP2D6
32blindness10.0INS
33mental retardation10.0PARK2
34acquired immunodeficiency syndrome10.0CARTPT
35hypertension10.0INS
36rabson-mendenhall syndrome10.0INS
37hypoadrenalism10.0GH1
38focal dystonia10.0PARK2
39metabolic acidosis10.0CHKB
40alpha thalassemia10.0BCL11A
41duodenal ulcer10.0INS
42anorexia nervosa10.0HCRT, GH1
43celiac disease10.0HLA-DQB1
44pancreatitis10.0INS
45adenocarcinoma10.0RPS6KB2, CYP2D6
46graves' disease10.0HLA-DRB1, HLA-DQB1
47multiple system atrophy10.0CYP2D6, PARK2
48craniopharyngioma10.0GH1, HCRT
49essential hypertension10.0CYP2D6, INS
50galactosemia10.0INS, CYP2D6

Graphical network of the top 20 diseases related to Hypersomnia:



Diseases related to hypersomnia

Clinical Features for Hypersomnia

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Drugs & Therapeutics for Hypersomnia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypersomnia

Drug clinical trials:

Search ClinicalTrials for Hypersomnia

Search NIH Clinical Center for Hypersomnia

Search CenterWatch for Hypersomnia

Genetic Tests for Hypersomnia

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Anatomical Context for Hypersomnia

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32MalaCards
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MalaCards organs/tissues related to Hypersomnia:

32
Brain

Animal Models for Hypersomnia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypersomnia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.3HLA-DQB1, GH1, CHKB, HCRT, INS, SPR
2MP:00053788.0SPR, PARK2, INS, HCRT, GH1, HLA-DQB1
3MP:00053767.5RPS6KB2, CPT1B, BCL11A, SPR, PARK2, INS

Publications for Hypersomnia

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Genetic Variations for Hypersomnia

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Expression for genes affiliated with Hypersomnia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersomnia

Search GEO for disease gene expression data for Hypersomnia.

Pathways for genes affiliated with Hypersomnia

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12EMD Millipore, 53Reactome, 51QIAGEN
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Pathways related to Hypersomnia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-DQB1, HLA-DRB1, TRA
29.3HLA-DQB1, HLA-DRB1, TRA
3
Immune response NFAT in immune response
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9.3TRA, HLA-DRB1, HLA-DQB1
49.3TRA, HLA-DRB1, HLA-DQB1
5
Immune response ICOS pathway in T-helper cell
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9.3TRA, HLA-DRB1, HLA-DQB1
6
Immune response Antigen presentation by MHC class II
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9.3TRA, HLA-DRB1, HLA-DQB1
7
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9.1PPP2R4, HLA-DQB1, HLA-DRB1

Compounds for genes affiliated with Hypersomnia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Hypersomnia according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.2CHKB, HCRT, SPR
2modafinil44 49 1112.2CYP2D6, HCRT
3oxandrolone44 1111.2INS, GH1
4phenformin44 1111.1INS, CYP2D6
5beta-hydroxybutyrate4410.1INS, CHKB, GH1
6gamma-hydroxybutyrate4410.1HCRT, CHKB
7methylphenidate44 49 1112.0CYP2D6, HCRT
8amphetamine44 1111.0CYP2D6, HCRT, CARTPT
9olanzapine49 44 28 11 2414.0INS, CYP2D6, CHKB
10carnitine449.9CPT1B, INS, CHKB
11androstenedione44 2410.8GH1, CYP2D6, INS
12cocaine44 1110.8CYP2D6, HCRT, CHKB, CARTPT
13thyroxine44 2410.8GH1, CHKB, HCRT, INS
14catecholamine449.8PARK2, HCRT, CHKB
15levodopa44 1110.8PARK2, CYP2D6, CHKB, GH1
16c-peptide449.8HLA-DRB1, GH1, HCRT, INS
17glycerol44 11 2411.8CPT1B, INS, CHKB, GH1
18epinephrine44 11 2411.7GH1, CHKB, HCRT, INS
19dextromethorphan2 49 11 2412.6CYP2D6, TAS2R1
20glucose449.6PPP2R4, CHKB, HCRT
21fatty acid449.5GH1, CHKB, CYP2D6, INS, CPT1B
22melatonin44 59 28 11 2413.4PPP2R4, GH1, HCRT, SPR
23gnrh449.2PPP2R4, GH1, HCRT, INS
24glutamine449.0PPP2R4, HLA-DQB1, GH1, CHKB, PARK2
25glycogen44 2410.0CPT1B, PARK2, INS, CHKB, PPP2R4
26cholesterol44 28 11 2411.8PPP2R4, CHKB, HCRT, CYP2D6, INS
27oligonucleotide448.7PPP2R4, HLA-DQB1, HLA-DRB1, GH1, HCRT, PARK2
28glutamate448.7PPP2R4, HLA-DQB1, HLA-DRB1, CHKB, HCRT, INS
29wortmannin448.6INS, GH1, PPP2R4, RPS6KB2
30estrogen448.6PPP2R4, GH1, CHKB, HCRT, INS, PARK2
31testosterone44 59 11 2411.5PPP2R4, GH1, CHKB, HCRT, CYP2D6, INS
32alanine448.4PPP2R4, HLA-DRB1, GH1, CHKB, HCRT, INS
33lipid448.4PPP2R4, GH1, HCRT, CYP2D6, INS, PARK2
34dopamine44 28 11 2411.3SPR, CARTPT, PPP2R4, GH1, CHKB, HCRT
35tyrosine448.0PPP2R4, HLA-DQB1, HLA-DRB1, GH1, HCRT, CYP2D6

GO Terms for genes affiliated with Hypersomnia

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16Gene Ontology
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Cellular components related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.0HLA-DRB1, HLA-DQB1

Biological processes related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune response mediated by circulating immunoglobulinGO:00245510.0HLA-DRB1, HLA-DQB1
2positive regulation of transmission of nerve impulseGO:0519719.8HCRT, CARTPT
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.7HLA-DRB1, HLA-DQB1

Molecular functions related to Hypersomnia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.0HLA-DRB1, HLA-DQB1

Products for genes affiliated with Hypersomnia

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Sources for Hypersomnia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet