Summaries for Hypersomnia

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NINDS:42 Hypersomnia is characterized by recurrent episodes of excessive daytime sleepiness or prolonged nighttime sleep. Different from feeling tired due to lack of or interrupted sleep at night, persons with hypersomnia are compelled to nap repeatedly during the day, often at inappropriate times such as at work, during a meal, or in conversation. These daytime naps usually provide no relief from symptoms. Patients often have difficulty waking from a long sleep, and may feel disoriented. Other symptoms may include anxiety, increased irritation, decreased energy, restlessness, slow thinking, slow speech, loss of appetite, hallucinations, and memory difficulty. Some patients lose the ability to function in family, social, occupational, or other settings. Hypersomnia may be caused by another sleep disorder (such as narcolepsy or sleep apnea), dysfunction of the autonomic nervous system, or drug or alcohol abuse. In some cases it results from a physical problem, such as a tumor, head trauma, or injury to the central nervous system. Certain medications, or medicine withdrawal, may also cause hypersomnia. Medical conditions including multiple sclerosis, depression, encephalitis, epilepsy, or obesity may contribute to the disorder. Some people appear to have a genetic predisposition to hypersomnia; in others, there is no known cause. Typically, hypersomnia is first recognized in adolescence or young adulthood.

MalaCards based summary: Hypersomnia is related to narcolepsy and sleep disorder. An important gene associated with Hypersomnia is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Cytokines and Inflammatory Response and Immune response NFAT in immune response. The compounds gamma-hydroxybutyrate and modafinil have been mentioned in the context of this disorder. Affiliated tissues include testes, hypothalamus and brain, and related mouse phenotypes are growth/size/body and behavior/neurological.

Wikipedia:63 In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders, published in May 2013,... more...

Aliases & Classifications for Hypersomnia

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Hypersomnia, Aliases & Descriptions:

Name: Hypersomnia 42


Related Diseases for Hypersomnia

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Diseases in the Hypersomnia family:

Recurrent Hypersomnia

Diseases related to Hypersomnia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1narcolepsy31.7HLA-DRB1, HCRT
2sleep disorder31.1CHKB, HCRT
3prader-willi syndrome30.4INS, HCRT, GH1
4hypothyroidism29.8CHKB, GH1, INS
5obesity29.5GH1, PARK2, INS, CPT1B, HCRT, CARTPT
6recurrent hypersomnia10.6
7narcolepsy 110.6HCRT
8sleep apnea10.6
9phenylketonuria10.5SPR
10kleine-levin syndrome10.5
11idiopathic hypersomnia without long sleep time10.4
12laron dwarfism10.4GH1
13idiopathic hypersomnolence10.4
14focal dystonia10.4PARK2
15pick disease10.4CHKB
16craniopharyngioma10.3HCRT, GH1
17neuroleptic malignant syndrome10.3CHKB, CYP2D6
18myotonic dystrophy10.3
19rabson-mendenhall syndrome10.3INS
20multiple sclerosis, disease progression, modifier of10.3HLA-DRB1, HLA-DQB1
21supranuclear palsy, progressive10.3PARK2, HCRT
22idiopathic hypersomnia with long sleep time10.3
23parkinson disease, late-onset10.3PARK2, CYP2D6
24eating disorder10.2INS
25leprosy10.2HLA-DRB1
26neuronitis10.2
27morbid obesity10.2INS
28tauopathy10.2PPP2R4, PARK2
29dementia, lewy body10.2CYP2D6, PARK2
30brain injury10.2
31traumatic brain injury10.2
32obstructive sleep apnea10.2
33acromegaly10.2
34acute disseminated encephalomyelitis10.2
35encephalitis10.2
36blindness10.2
37dilated cardiomyopathy10.1HLA-DQB1, HLA-DRB1, CHKB
38autoimmune hepatitis10.1HLA-DQB1, CYP2D6, HLA-DRB1
39dementia10.1CYP2D6, HCRT, PARK2
40oligomenorrhea10.1INS, GH1
41hepatitis c10.1HLA-DRB1, PPP2R4, CYP2D6
42pituitary gland disease10.1INS, GH1
43bipolar disorder10.1
44mood disorder10.1
45juvenile rheumatoid arthritis10.0HLA-DRB1, HLA-DQB1
46growth hormone deficiency10.0INS, GH1
47hypopituitarism10.0INS, GH1
48systemic lupus erythematosus10.0TRA, HLA-DQB1, CYP2D6, HLA-DRB1
49ulcerative colitis10.0TRA, HLA-DRB1, CHKB
50hypoglycemia10.0HCRT, INS, GH1

Graphical network of the top 20 diseases related to Hypersomnia:



Diseases related to hypersomnia

Symptoms for Hypersomnia

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Drugs & Therapeutics for Hypersomnia

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Drug clinical trials:

Search ClinicalTrials for Hypersomnia

Search NIH Clinical Center for Hypersomnia

Genetic Tests for Hypersomnia

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Anatomical Context for Hypersomnia

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MalaCards organs/tissues related to Hypersomnia:

31
Testes, Hypothalamus, Brain, Eye, Thalamus, Amygdala, Pituitary

Animal Models for Hypersomnia or affiliated genes

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MGI Mouse Phenotypes related to Hypersomnia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1SPRED1, HLA-DQB1, HCRT, INS, PARK2, GH1
2MP:00053867.9SPR, SPRED1, HLA-DQB1, HCRT, INS, PARK2
3MP:00036317.7SPR, SPRED1, HLA-DQB1, HCRT, INS, PARK2
4MP:00053767.6CARTPT, SPR, HLA-DQB1, HCRT, INS, CPT1B

Publications for Hypersomnia

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Articles related to Hypersomnia:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
Sleepiness and Performance Is Disproportionate in Patients with Non-Organic Hypersomnia in Comparison to Patients with Narcolepsy and Mild to Moderate Obstructive Sleep Apnoea. (25377356)
2014
2
Modafinil in the treatment of idiopathic hypersomnia without long sleep time-a randomized, double-blind, placebo-controlled study. (25196321)
2014
3
Use of subcutaneous flumazenil preparations for the treatment of idiopathic hypersomnia: A case report. (24554692)
2014
4
Polysomnographic study of nocturnal sleep in idiopathic hypersomnia without long sleep time. (23061443)
2013
5
Left temporopolar impairment in a case of posttraumatic hypersomnia. (23407426)
2013
6
Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. (23646285)
2013
7
Case 16-2013: A girl with irritability, hypersomnia, and somatic symptoms. (24047075)
2013
8
Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience. (24306133)
2013
9
Recurrent hypersomnia due to occult hepatic encephalopathy. (22154356)
2012
10
Clarithromycin-induced hypersomnia in children. (21543032)
2011
11
The pathophysiologic basis of secondary narcolepsy and hypersomnia. (21298561)
2011
12
Recurrent hypersomnia: a review of 339 cases. (20970360)
2011
13
Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. (19927159)
2010
14
Non-convulsive status epilepticus presenting as recurrent hypersomnia. (20463123)
2010
15
Neurosarcoidosis presenting as spontaneously remitting hypersomnia. (19609590)
2009
16
Idiopathic hypersomnia: clinical features and response to treatment. (20465024)
2009
17
Diagnostic pitfalls in children with sleep disorders: two cases with hypersomnia. (18754824)
2008
18
Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats. (17853446)
2007
19
Narcolepsy, metabolic syndrome and obstructive sleep apnea syndrome as the causes of hypersomnia in children. Report of three cases. (18229667)
2007
20
Episodic hypersomnia and unusual behaviors in a 14-year old adolescent. (18091094)
2007
21
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder. (16854470)
2006
22
Sleeping in? The impact of age and depressive sub-type on hypersomnia. (16325918)
2006
23
Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. (16006155)
2005
24
Hypersomnia associated with bilateral posterior hypothalamic lesion. A polysomnographic case study. (12646762)
2003
25
Sleep and EEG power spectrum in post encephalitis hypersomnia: a case report. (14592236)
2002
26
Is dawn simulation effective in ameliorating the difficulty awakening in seasonal affective disorder associated with hypersomnia? (12103471)
2002
27
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. (12374492)
2002
28
Hypersomnia in MS. (12499505)
2002
29
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. (11477286)
2001
30
Law of denervation and spinal mechanism of leg movements in sleep. Commentary on controversies in sleep medicineMontplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopamineergic mechanism. (11438257)
2001
31
Multiple sleep latency test and polysomnography in diagnosing Kleine-Levin syndrome and periodic hypersomnia. (11085556)
2000
32
Hypersomnia after tegmental pontine hematoma: case report. (7756013)
1995
33
Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia: a study of two unrelated Italian cases. (8256576)
1993
34
Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome. (1963255)
1990
35
Hypersomnia, bithalamic lesions, and altered sleep architecture in Kearns-Sayre syndrome. (3982647)
1985
36
Cerebrospinal fluid monoamine metabolites in narcolepsy and hypersomnia. (6189447)
1983
37
Effects of expiratory positive airway pressure on sleep-induced respiratory abnormalities in patients with hypersomnia-sleep apnea syndrome. (6354028)
1983
38
Narcolepsy and idiopthic hypersomnia: biogenic amines and related compounds in CSF. (6890168)
1982
39
Hypersomnia associated with alveolar hypoventilation in myotonic dystrophy. (7202141)
1981
40
Lithium prophylaxis of periodic hypersomnia. (843779)
1977
41
Periodic megaphagia and hypersomnia--an example of the Kleine-Levin syndrome in an adolescent girl. (4719411)
1973
42
Micrognathia, hypersomnia and periodic breathing. (4657867)
1972
43
Diagnosis and dramatic cure in two patients suffering from severe diurnal hypersomnia. (4191233)
1970
44
Hypersomnia and car driving. (4097446)
1970
45
REM sleep and NREM sleep in narcolepsy and hypersomnia. (4183371)
1969
46
Hypersomnia. A discussion of psychiatric implications based on three cases. (5636091)
1968
47
Psychopathological investigation of a case of periodic hypersomnia and Bulimia (Kleine-Levin syndrome). (5235707)
1967
48
The Kleine-Levin syndrome: hypersomnia, bulimia, and abnormal mental states. (13896459)
1962
49
Multiple Angiolipomata and Hypersomnia. (19993785)
1951
50
A case of periodic hypersomnia. (14895817)
1951

Variations for Hypersomnia

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Expression for genes affiliated with Hypersomnia

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Search GEO for disease gene expression data for Hypersomnia.

Pathways for genes affiliated with Hypersomnia

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Pathways related to Hypersomnia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TRA, HLA-DRB1
2
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.2TRA, HLA-DRB1, HLA-DQB1
3
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.2TRA, HLA-DRB1, HLA-DQB1
4
Show member pathways
9.0PPP2R4, HLA-DQB1, HLA-DRB1

Compounds for genes affiliated with Hypersomnia

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Compounds related to Hypersomnia according to GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1gamma-hydroxybutyrate4310.3HCRT, CHKB
2modafinil43 49 1212.3HCRT, CYP2D6
3methylphenidate43 49 1212.2HCRT, CYP2D6
4amphetamine43 49 1212.1CYP2D6, HCRT, CARTPT
5oxandrolone43 1211.1GH1, INS
6phenformin43 1211.1INS, CYP2D6
7acipimox43 2811.0INS, GH1
8nateglinide43 49 1212.0INS, CYP2D6
9carnitine439.9CHKB, CPT1B, INS
10beta-hydroxybutyrate439.9INS, CHKB, GH1
11cocaine43 1210.9CARTPT, CHKB, HCRT, CYP2D6
12intralipid439.9INS, GH1
13catecholamine439.9HCRT, PARK2, CHKB
14dextromethorphan2 49 24 1212.9CYP2D6, TAS2R1
15olanzapine43 49 28 24 1213.9CYP2D6, INS, CHKB
16androstenedione43 2410.8CYP2D6, INS, GH1
171 methyl 4 phenylpyridinium439.8PARK2, CYP2D6
18cortisone43 2410.7GH1, INS
19rosiglitazone28 43 49 24 1213.7GH1, INS, CYP2D6
20bamhi439.7HLA-DQB1, TRA
21thyroxine43 2410.7GH1, CHKB, INS, HCRT
22estradiol43 24 1211.7GH1, CHKB, HCRT, CYP2D6
23epinephrine43 24 1211.7GH1, CHKB, INS, HCRT
24glycerol43 24 1211.7INS, CPT1B, CHKB, GH1
25clomiphene citrate439.6GH1, INS
26c-peptide439.6HLA-DRB1, HCRT, INS, GH1
27levodopa43 1210.6CYP2D6, PARK2, CHKB, GH1
28norepinephrine43 24 1211.5SPR, HCRT, INS, CHKB, GH1
29doxazosin43 1210.5INS, CYP2D6
30fatty acid439.4CYP2D6, INS, CPT1B, CHKB, GH1
31nitric oxide43 24 1211.4SPR, CYP2D6, HCRT, PARK2, CHKB
32melatonin43 28 59 24 1213.3GH1, HCRT, SPR, PPP2R4
33dexamethasone43 49 28 1212.3CYP2D6, HCRT, INS, CHKB, GH1
34gnrh439.1GH1, INS, HCRT, PPP2R4
35cholesterol43 28 24 1211.9PPP2R4, CYP2D6, HCRT, INS, CHKB
36lysine438.9PPP2R4, HLA-DRB1, PARK2, CHKB
37glutamine438.7PPP2R4, HLA-DQB1, PARK2, CHKB, GH1
38glycogen43 249.7PPP2R4, INS, CPT1B, PARK2, CHKB
39arginine438.6PPP2R4, HLA-DRB1, INS, CHKB, GH1
40leucine438.6PPP2R4, PARK2, CHKB, GH1
41glutamate438.6PPP2R4, HLA-DQB1, HLA-DRB1, HCRT, INS, CHKB
42atp43 289.5PPP2R4, HLA-DRB1, HCRT, PARK2, CHKB
43oligonucleotide438.5PPP2R4, HLA-DQB1, HLA-DRB1, HCRT, PARK2, GH1
44estrogen438.4PPP2R4, HCRT, INS, PARK2, CHKB, GH1
45glucose438.2PPP2R4, HCRT, INS, CPT1B, PARK2, CHKB
46testosterone43 59 24 1211.2PPP2R4, CYP2D6, HCRT, INS, PARK2, CHKB
47lipid438.2PPP2R4, CYP2D6, HCRT, INS, CPT1B, PARK2
48dopamine43 28 24 1211.1CARTPT, PPP2R4, SPR, CYP2D6, HCRT, PARK2
49alanine438.1PPP2R4, HLA-DRB1, HCRT, INS, PARK2, CHKB
50tyrosine437.6PPP2R4, SPR, HLA-DQB1, HLA-DRB1, CYP2D6, HCRT

GO Terms for genes affiliated with Hypersomnia

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Cellular components related to Hypersomnia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:00306699.8HLA-DRB1, HLA-DQB1
2MHC class II protein complexGO:00426139.7HLA-DRB1, HLA-DQB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.5HLA-DRB1, HLA-DQB1

Biological processes related to Hypersomnia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transmission of nerve impulseGO:005197110.0CARTPT, HCRT
2humoral immune response mediated by circulating immunoglobulinGO:00024559.8HLA-DRB1, HLA-DQB1
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.5HLA-DRB1, HLA-DQB1

Molecular functions related to Hypersomnia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.8HLA-DRB1, HLA-DQB1

Products for genes affiliated with Hypersomnia

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Sources for Hypersomnia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet