MCID: HYP063
MIFTS: 58

Hypersplenism malady

Immune diseases, Blood diseases categories

Summaries for Hypersplenism

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66Wikipedia, 34MalaCards
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Wikipedia:66 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards: Hypersplenism, also known as hypersplenia, is related to portal hypertension and splenomegaly. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds anagrelide and mafosfamide have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone marrow, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Hypersplenism

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 41NCIt, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

hypersplenism 9 11 46 63
hypersplenia 9


External Ids:

Disease Ontology9 DOID:6376
MeSH36 D006971
NCIt41 C34714
ICD9CM28 289.4
ICD1026 D73.1

Related Diseases for Hypersplenism

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18GeneCards, 19GeneDecks
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Diseases related to Hypersplenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension31.1EVL
2splenomegaly30.9GBA, THPO, EPO, IL2RA, CSF3
3hepatitis30.8ALB, THPO, F2
4liver cirrhosis30.7F2, THPO, SERPINC1, ALB
5hepatitis c30.6TLR4, THPO, F2
6hepatocellular carcinoma30.6F2, PIK3R1, TLR4, FOXP3, ALB, CD4
7thrombocytopenia30.4CD4, ALB, CSF3, CSF2, EPO, SERPINC1
8pancytopenia30.2GBA, THPO, EPO, IL2RA, CSF2, CSF3
9tuberculosis30.2TLR4, IL2RA, ALB, CD4
10portal vein thrombosis30.2SERPINC1, THPO, F2
11myelofibrosis30.2THPO, EPO
12acquired immunodeficiency syndrome30.1CSF2, ALB, CD4
13felty's syndrome30.1CSF2, CSF3
14hepatitis b30.1F2, TLR4, ALB, CD4
15arthritis30.0CD4, ALB, CSF2, FOXP3, TLR4
16arteriovenous fistula30.0EPO
17purpura30.0THPO, SERPINC1
18malaria29.9ALB, CD4
19vascular disease29.9CD4, SERPINC1
20polycythemia29.9THPO, EPO
21leukemia29.8GBA, PIK3R1, THPO, TLR4, EPO, REL
22t-cell leukemia29.8RELA, REL, FOXP3, IL2RA, CD4
23stomatitis29.8CSF3, CSF2
24myeloproliferative disorder29.8THPO, EPO, CSF2, CSF3
25neutropenia29.8THPO, EPO, CSF2, CSF3
26acute leukemia29.8CSF3, CSF2, EPO, THPO
27hodgkin's lymphoma29.8PIK3R1, REL, IL2RA, CSF2, CSF3
28hypertension10.6
29liver disease10.3
30hepatitis c virus10.2
31sickle cell anemia10.2
32sickle cell disease10.2
33capillary leak syndrome10.1CSF2
34gaucher's disease10.1
35lymphosarcoma10.1
36pancreatitis10.1
37aneurysm10.1
38autoimmune thrombocytopenic purpura10.1THPO
39hydrops fetalis10.1GBA
40purpura fulminans10.1SERPINC1
41cryptosporidiosis10.1CD4
42sneddon syndrome10.1SERPINC1
43factor xii deficiency10.1SERPINC1
44cryptococcosis10.1CD4
45pyelonephritis10.1TLR4
46bernard-soulier syndrome10.1F2, THPO
47dysfibrinogenemia10.1SERPINC1, F2
48prothrombin deficiency10.1F2, SERPINC1
495q- syndrome10.1EPO
50megakaryocytic leukemia10.1THPO, CSF2

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to hypersplenism

Symptoms for Hypersplenism

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Drugs & Therapeutics for Hypersplenism

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Genetic Tests for Hypersplenism

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Anatomical Context for Hypersplenism

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34MalaCards
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MalaCards organs/tissues related to Hypersplenism:

34
Spleen, Liver, Bone marrow, Bone, T cells, Myeloid, B cells, Testes, Pineal, Pancreas, Brain, Breast

Animal Models for Hypersplenism or affiliated genes

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38MGI
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Publications for Hypersplenism

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53PubMed
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Articles related to Hypersplenism:

(show top 50)    (show all 421)
idTitleAuthorsYear
1
Opportunistic Fonsecaea pedrosoi brain abscess in a patient with non-cirrhotic portal fibrosis-induced hypersplenism--a novel association. (23458558)
2013
2
Prophylaxis against hepatitis B virus recurrence after liver transplantation for hepatitis B virus-related end-stage liver diseases with severe hypersplenism and splenomegaly: role of splenectomy. (22483806)
2012
3
Partial splenic embolization using Bletilla striata particles for hypersplenism in cirrhosis: a prospective study. (21476204)
2011
4
Total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism. (21734807)
2011
5
Partial splenic embolization as an alternative to splenectomy in hypersplenism--single center experience in 16 years. (20862632)
2010
6
Hypersplenism caused by an accessory spleen mimicking an intra-abdominal neoplasm: report of a case. (19779782)
2009
7
Portal hypertension and hypersplenism in a patient with a Bochdalek hernia: a case report. (18398560)
2009
8
Two-year follow-up of splenic radiofrequency ablation in patients with cirrhotic hypersplenism: does increased hepatic arterial flow induce liver regeneration? (18374048)
2008
9
Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. (19039645)
2008
10
Congenital absence of the portal vein with splenomegaly and hypersplenism in a young woman. (12743449)
2003
11
Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. (12753144)
2003
12
Acute hypersplenism with splenomegaly after portal vein embolization. (12075192)
2002
13
Interleukin-11 administration normalizes the platelet count in a hypersplenic cirrhotic patient. (12424546)
2002
14
The first experience with non-operative treatment of hypersplenism in children with portal hypertension. (12469254)
2002
15
Partial splenic embolization for hypersplenism before and after liver transplantation. (12372046)
2002
16
Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome. (11170921)
2001
17
Hypersplenism. (11338057)
2001
18
Locoregional intrasplenic chemotherapy for hypersplenism in myelofibrosis. (11552991)
2001
19
Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. (11139352)
2000
20
Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis. (8946990)
1996
21
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism...". (8855767)
1996
22
A long-term investigation of transcatheter splenic arterial embolization for hypersplenism. (8682485)
1996
23
Partial splenic embolisation and improvement of hypersplenism before liver transplantation. (7741576)
1995
24
Hypersplenism in liver cirrhosis: is conservative treatment still best? (8857456)
1995
25
Splenic ablation by percutaneous injection of ethanolamine oleate in dogs: a possible therapy for hypersplenism. (2606310)
1989
26
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
27
Hypersplenism secondary to a ruptured gallbladder and a pericholecystic abscess that presented as staphylococcal septicemia. (3949560)
1986
28
Computed tomography follow-up of nonsurgical treatment for hypersplenism. (3731807)
1986
29
Clinical disorders of splenic function: the spectrum from asplenism to hypersplenism. (6887967)
1983
30
Splenic embolization in a child with hypersplenism. (7161676)
1982
31
Partial splenic embolization in the management of hypersplenism secondary to Gaucher disease. (7131151)
1982
32
Isoniazid-related liver disease. Occurrence with portal hypertension, hypoalbuminemia, and hypersplenism. (448941)
1979
33
Splenectomy for hypersplenism. (707906)
1978
34
Control of hypersplenism and painful splenomegaly in myeloid metaplasia by irradiation. (413815)
1977
35
Hypersplenism in Hodgkin's disease: a report of three cases presenting with cytopenias. (593655)
1977
36
Experimental hypersplenism in mice. (131348)
1976
37
Partial splenectomy and pleural splenic transposition, a new approach to congestive hypersplenism of portal hypertension. (5037265)
1972
38
The kinetics of plaque-forming cells in experimental hypersplenism. (4999135)
1971
39
HYPERSPLENISM IN SICKLE CELL ANEMIA. (14170620)
1964
40
Hypersplenism. (13749081)
1961
41
Hypersplenism due to infection. A study of five cases manifesting hemolytic anemia. (13789380)
1961
42
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
43
Hypersplenism. (13230762)
1955
44
Secondary hypersplenism with recurrent gastrointestinal bleeding. (13059633)
1953
45
Surgical aspects of hypersplenism. (13036936)
1953
46
Pancreatic cyst; an unusual cause of hypersplenism. (12996227)
1952
47
Hypersplenism. (14863408)
1951
48
The use of ACTH in hypersplenism. (14931201)
1951
49
Hypersplenism in a patient with lymphogranuloma benignum. (15391143)
1949
50
The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. (21013546)
1946

Variations for Hypersplenism

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Expression for genes affiliated with Hypersplenism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

Pathways for genes affiliated with Hypersplenism

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51PathCards, 39NCBI BioSystems Database, 55R&D Systems, 54QIAGEN, 31KEGG, 61Thomson Reuters, 13EMD Millipore, 56Reactome, 5Cell Signaling Technology, 62Tocris Bioscience
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Pathways related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.6FOXP3, IL2RA, CSF2
2
Show member pathways
9.6FOXP3, IL2RA, CSF2
3
Show member pathways
9.5CD4, IL2RA, PIK3R1
4
Show member pathways
9.4F2, PIK3R1, THPO, IL2RA
59.4CD4, CSF3, CSF2
69.1IL7R, IL2RA, RELA
7
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.1PIK3R1, RELA, REL
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.1REL, RELA, PIK3R1
99.1REL, RELA, PIK3R1
109.1REL, RELA, PIK3R1
11
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.1REL, RELA, PIK3R1
12
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.1REL, RELA, PIK3R1
13
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.1REL, RELA, PIK3R1
149.0TLR4, RELA, REL
15
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.0REL, RELA, TLR4
169.0PIK3R1, RELA, CSF2
17
Show member pathways
9.0IL2RA, RELA, PIK3R1
18
Show member pathways
8.9CSF2, RELA, TLR4
19
Show member pathways
thioredoxin pathway39
8.9F2, RELA, ALB
20
Show member pathways
8.9PIK3R1, TLR4, RELA
21
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.8RELA, REL, IL2RA, CD4
22
Show member pathways
8.8F2, PIK3R1, THPO, SERPINC1, ALB
23
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
8.8PIK3R1, RELA, REL, CD4
24
Show member pathways
8.8CD4, REL, RELA, PIK3R1
25
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.8CSF2, REL, RELA, PIK3R1
26
Show member pathways
Immune response IL 3 activation and signaling pathway61
8.8PIK3R1, RELA, REL, IL2RA
27
Show member pathways
IL2 signaling events mediated by STAT539
8.7IL2RA, FOXP3, RELA, PIK3R1
288.7PIK3R1, RELA, IL2RA, CSF2
29
Show member pathways
8.7PIK3R1, TLR4, RELA, FOXP3
308.6PIK3R1, TLR4, RELA, CSF2
31
Show member pathways
8.6PIK3R1, TLR4, RELA, IL2RA
32
Show member pathways
8.6IL2RA, RELA, TLR4, PIK3R1
33
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6F2, PIK3R1, RELA, REL, CD4
34
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.5PIK3R1, THPO, RELA, IL2RA, IL7R
35
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.5PIK3R1, RELA, REL, CSF2, CD4
36
Show member pathways
8.5PIK3R1, THPO, TLR4, RELA, REL
378.4RELA, EPO, TLR4, PIK3R1
38
Show member pathways
8.4PIK3R1, RELA, IL2RA, IL7R, CSF2
39
Show member pathways
8.4PIK3R1, RELA, IL2RA, IL7R, CSF2
40
Show member pathways
8.4CD4, EVL, RELA, PIK3R1
41
Show member pathways
8.4F2, PIK3R1, THPO, EPO, IL2RA, IL7R
42
Show member pathways
Type III interferon signaling39
8.3PIK3R1, EPO, IL2RA, IL7R, CSF2, CSF3
43
Show member pathways
8.2PIK3R1, THPO, IL2RA, IL7R, CSF2, CSF3
44
Show member pathways
8.2PIK3R1, THPO, IL2RA, IL7R, CSF2, CSF3
45
Show member pathways
8.2CD4, EVL, REL, RELA, PIK3R1
468.1CD4, THPO, EPO, IL2RA, IL7R, CSF2
47
Show member pathways
7.9TLR4, RELA, REL, FOXP3, CSF2, CSF3
48
Show member pathways
7.8PIK3R1, THPO, TLR4, IL2RA, IL7R, CSF2
497.3PIK3R1, TLR4, EPO, RELA, IL2RA, IL7R
50
Show member pathways
6.5F2, PIK3R1, TLR4, EPO, RELA, IL2RA

Compounds for genes affiliated with Hypersplenism

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB, 62Tocris Bioscience, 25HMDB
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Compounds related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1anagrelide46 1210.9THPO, CSF2, EPO
2mafosfamide469.8CSF3, THPO, CSF2
3hepaplastin469.7SERPINC1, ALB, F2
4tranexamic acid46 1210.7F2, EPO, SERPINC1
5phenprocoumon46 52 1211.7F2, SERPINC1, ALB
6pegfilgrastim46 1210.6CSF2, CSF3, EPO
7epsilon aminocaproic acid469.4SERPINC1, F2, EPO
8pixy321469.4CSF3, EPO, THPO, CSF2
9amifostine46 1210.4CSF3, EPO, THPO, CSF2
10filgrastim46 1210.4THPO, CSF2, CSF3, EPO
11gm-csf46 3010.4THPO, EPO, CSF2, CSF3
12anti-fungal469.4CSF3, CSF2, TLR4, REL
13methylcellulose469.4CSF3, CSF2, THPO, EPO
14polyethylene glycol469.4SERPINC1, F2, THPO, ALB
15chloroquine46 3 52 30 1213.3SERPINC1, TLR4, CD4, IL2RA
16hydroxyethyl starch469.3SERPINC1, CSF3, F2, ALB
17carboplatin46 52 1211.2EPO, CSF3, CSF2, THPO
18hydroxyurea46 52 1211.2CSF3, F2, CSF2, THPO, EPO
19bleomycin46 1210.2CSF2, EPO, IL2RA, CSF3
20etoposide46 52 62 1212.0PIK3R1, IL2RA, CSF2, CSF3, THPO
21mycophenolate mofetil46 52 1211.0ALB, CSF3, EPO, IL2RA
22aminoguanidine46 30 1211.0TLR4, EPO, ALB
23genistein46 30 62 3 25 1214.0PIK3R1, IL2RA, TLR4, CSF2, THPO, CD4
24pge2468.9CSF2, FOXP3, TLR4, SERPINC1, IL2RA, CD4
25fibrinogen468.9ALB, SERPINC1, TLR4, THPO, F2
26aspirin46 52 30 2511.8GBA, F2, THPO, TLR4, SERPINC1, IL2RA
27zidovudine46 52 1210.8CD4, ALB, CSF2, EPO, CSF3
28imatinib46 52 1210.8THPO, PIK3R1, EPO, CSF3, ALB
29polysaccharide468.7TLR4, THPO, SERPINC1, CSF2, GBA, IL2RA
30estrogen468.7CSF2, PIK3R1, IL2RA, F2, THPO, SERPINC1
31histamine46 30 2510.7THPO, TLR4, IL2RA, ALB, CSF2
32lactate468.7ALB, EPO, F2, TLR4, THPO, CSF2
33creatinine468.7F2, IL2RA, SERPINC1, EPO, ALB, THPO
34calcitriol46 62 25 1211.7CSF2, IL2RA, EPO, TLR4, F2, ALB
35rantes468.6CD4, CSF3, CSF2, REL, THPO, IL2RA
36vitamin d468.6ALB, TLR4, EPO, CSF2, IL2RA
37phospholipid468.6PIK3R1, IL2RA, TLR4, GBA, F2
38gp 130468.5CSF3, CSF2, IL7R, PIK3R1, THPO, EPO
39aspartate468.5EPO, ALB, IL2RA, TLR4, PIK3R1, F2
40thymidine46 259.5PIK3R1, GBA, IL2RA, CSF2, EPO, CSF3
41heparin46 30 25 1211.4THPO, CSF2, IL7R, IL2RA, SERPINC1, F2
42cysteine468.3CSF2, ALB, CD4, IL2RA, REL, TLR4
43phosphatidylinositol468.3CD4, CSF2, IL7R, IL2RA, EPO, THPO
44cyclosporin a46 30 6210.2F2, REL, FOXP3, IL2RA, CSF2, CSF3
45methotrexate52 46 1210.2F2, TLR4, EPO, IL2RA, ALB, CSF3
46dexamethasone46 52 30 1211.2CSF2, REL, CSF3, SERPINC1, IL2RA, TLR4
47vegf468.0THPO, PIK3R1, CSF3, TLR4, SERPINC1, EPO
48testosterone46 62 25 1210.7EPO, IL2RA, ALB, PIK3R1, SERPINC1, RELA
49serine467.7PIK3R1, RELA, F2, GBA, CD4, REL
50tyrosine467.6EPO, REL, IL2RA, IL7R, CSF2, CD4

GO Terms for genes affiliated with Hypersplenism

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17Gene Ontology
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Cellular components related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4ALB, SERPINC1, F2
2external side of plasma membraneGO:0098979.1TLR4, IL2RA, IL7R, CD4
3extracellular regionGO:0055768.0F2, SERPINC1, EPO, IL7R, CSF2, ALB
4extracellular spaceGO:0056157.9ALB, CSF3, CSF2, EPO, SERPINC1, THPO

Biological processes related to Hypersplenism according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immune responseGO:05077710.1FOXP3, IL2RA
2cytokine productionGO:00181610.0REL, FOXP3, CD4
3macrophage activationGO:04211610.0TLR4, CSF2
4negative regulation of neuron deathGO:19012159.9CSF3, REL
5negative regulation of interleukin-6 productionGO:0327159.9FOXP3, TLR4, GBA
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9CSF2, EPO
7negative regulation of osteoclast differentiationGO:0456719.8TLR4, PIK3R1
8negative regulation of interferon-gamma productionGO:0326899.8FOXP3, TLR4
9negative regulation of inflammatory responseGO:0507289.8IL2RA, SERPINC1, GBA
10response to testosteroneGO:0335749.7EPO, GBA
11defense response to Gram-negative bacteriumGO:0508299.5CD4, TLR4
12platelet activationGO:0301689.4F2, PIK3R1, THPO, ALB
13positive regulation of interleukin-12 biosynthetic processGO:0450849.4TLR4, RELA, REL
14cell surface receptor signaling pathwayGO:0071669.1CD4, EVL, IL7R, IL2RA, F2
15T cell receptor signaling pathwayGO:0508529.1PIK3R1, RELA, FOXP3, CD4
16blood coagulationGO:0075969.1F2, PIK3R1, THPO, SERPINC1, ALB
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1TLR4, RELA, REL
18cellular response to lipopolysaccharideGO:0712228.7TLR4, RELA, CSF2, CSF3
19immune responseGO:0069558.7CD4, CSF3, CSF2, IL7R, IL2RA, TLR4
20positive regulation of transcription, DNA-templatedGO:0458938.7EPO, RELA, REL, FOXP3
21positive regulation of cell proliferationGO:0082848.4CSF3, CSF2, RELA, EPO, F2
22positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CSF3, FOXP3, RELA, TLR4, PIK3R1

Molecular functions related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NF-kappaB bindingGO:0510599.4FOXP3, RELA
2cytokine activityGO:0051259.1CSF3, CSF2, THPO
3growth factor activityGO:0080839.1F2, THPO, CSF2, CSF3
4protein bindingGO:0055155.1CD4, GBA, F2, PIK3R1, TLR4, SERPINC1

Products for genes affiliated with Hypersplenism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet