Hypersplenism malady

Wikipedia: Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)...⁴⁴ more...

MalaCards: Hypersplenism, also known as hypersplenism (disorder), is related to splenomegaly and portal hypertension. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are Molecular Mechanisms of Cancer and Jak-STAT signaling pathway. The compounds etoposide and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and bone marrow, and related mouse phenotypes are liver/biliary system and immune system.

Aliases & Descriptions:

hypersplenism 6 8 32 43 hypersplenism (disorder) 6

hypersplenia 6

Diseases related to hypersplenism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 308)

id	Related Disease	Score	Top Affiliating Genes
1	splenomegaly	28.4	THPO, CSF3, EPO, GBA
2	portal hypertension	27.8	F2, ALB, THPO
3	liver cirrhosis	27.3	IL11, F2, ALB, THPO
4	thrombocytopenia	24.8	IL11, F2, ALB, TLR4, THPO, CSF2
5	hypertension	23.2	PIK3R1, F2, ALB, EVL, TLR4, THPO
6	acquired thrombocytopenia	13.4	IL11, THPO
7	bernard-soulier syndrome	13.3	F2, THPO
8	autoimmune thrombocytopenic purpura	13.3	IL11, THPO
9	von willebrand's disease	13.3	IL11, F2
10	dengue disease	13.3	IL11, THPO
11	esophageal varix	13.2	F2, ALB
12	purpura fulminans	13.2	F2, CSF3
13	hepatic tuberculosis	13.2	F2, ALB
14	bleeding diathesis due to gnaq deficiency	13.2	F2, GBA
15	acute fatty liver of pregnancy	13.2	F2, ALB
16	fournier gangrene	13.2	F2, ALB
17	warfarin resistance	13.2	F2, ALB
18	cyclic hematopoiesis	13.2	CSF2, CSF3
19	severe congenital neutropenia	13.2	CSF2, CSF3
20	myelokathexis	13.2	CSF2, CSF3
21	leukemoid reaction	13.1	CSF2, CSF3
22	dysfibrinogenemia	13.1	F2, ALB
23	myelofibrosis	13.1	THPO, EPO
24	granulocytopenia	13.1	CSF2, CSF3
25	chronic neutrophilic leukemia	13.1	CSF2, CSF3
26	short limb dwarf edema iris coloboma	13.1	IL11, ALB
27	hepatorenal syndrome	13.1	F2, ALB
28	thrombophlebitis	13.1	F2, EPO
29	felty's syndrome	13.1	CSF2, CSF3
30	anemia of prematurity	13.1	CSF2, EPO
31	compartment syndrome	13.1	F2, ALB
32	hypofibrinogenemia	13.1	F2, ALB
33	scabies	13.1	F2, CSF3
34	perinephritis	13.1	ALB, CSF3
35	acute megakaryoblastic leukemia	13.0	IL11, THPO, CSF2
36	bilirubin metabolic disorder	13.0	F2, ALB
37	alcoholic hepatitis	13.0	F2, ALB
38	acute graft versus host disease	13.0	THPO, CSF3
39	meconium aspiration syndrome	13.0	CSF2, CSF3
40	diabetic foot ulcers	13.0	F2, CSF3
41	acute liver failure	13.0	F2, ALB, THPO
42	renal hypertension	13.0	ALB, EPO
43	infective endocarditis	12.9	F2, EPO
44	galactosemia	12.9	F2, ALB, THPO
45	vericose veins	12.9	F2, ALB, EVL
46	thrombotic thrombocytopenic purpura, acquired	12.9	F2, THPO, EPO
47	calciphylaxis	12.9	ALB, EPO
48	hepatitis	12.9	F2, ALB, THPO
49	essential thrombocythemia	12.9	IL11, THPO, EPO
50	chronic myelomonocytic leukemia	12.9	CSF2, CSF3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypersplenism:

²²

MGI Mouse Phenotypes related to hypersplenism:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.1	TLR4, EPO, GBA
2	immune system phenotype	MP:0005387	8.3	GBA, CSF2, TLR4, EVL, F2
3	cardiovascular system phenotype	MP:0005385	7.3	GBA, EPO, CSF2, TLR4, EVL, F2
4	integument phenotype	MP:0010771	7.3	GBA, EPO, CSF3, CSF2, TLR4, F2
5	hematopoietic system phenotype	MP:0005397	6.8	PIK3R1, GBA, EPO, CSF3, CSF2, THPO
6	homeostasis/metabolism phenotype	MP:0005376	6.7	GBA, EPO, CSF2, TLR4, EVL, ALB
7	mortality/aging	MP:0010768	6.4	GBA, EPO, CSF2, TLR4, EVL, ALB

Articles related to hypersplenism:

id	Title	Authors	Year	Affiliating Genes
1	Knockdown of PIK3R1 by shRNA inhibits the activity of the splenic macrophages associated with hypersplenism due to portal hypertensi on. (20846792)	Zhang W.... Yang A.N.	2010	PIK3R1
2	Thrombocytopenia in association with splenomegaly during granulocyte-colony-stimulating factor treatment in mice is not caused by hypersplenism and is resolved spontaneously. (17207228)	Takamatsu Y.... Tamura K.	2007	CSF3
3	Safe use of pegylated interferon/ribavirin in hepatit is C virus cirrhotic patients with hypersplenism after partial splenic emboliza tion. (16215426)	Foruny J.R.... Moreno S.	2005	CSF3, EPO
4	Expression and significance of Toll-like receptor 4 of splenic macrophage in patients with hypersplenism due to portal hypertension (15312508)	Li Z.F.... Liu X.G.	2004	TLR4
5	Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. (12753144)	Sanjo A.... Suzuki N.	2003	THPO
6	Interleukin-11 administration normalizes the platelet count in a hypersplenic cirrhotic patient. (12424546)	Ustun C.... Faguet G.B.	2002	IL11
7	Partial splenic embolization for the treatment of liver cirrhosis with hypersplenism: assessment of clinical response and liver function (9284441)	Numata S.... Fujishima M.	1997	ALB
8	A long-term investigation of transcatheter splenic arterial embolization for hypersplenism. (8682485)	Sakata K.... Tanikawa K.	1996	ALB
9	The use of granulocyte-macrophage colony-stimulating factor to enhance hematologic parameters of patients with cirrhosis and hypersplenism. (7814805)	Gurakar A.... Carr B.I.	1994	CSF2
10	High plasma concentration of myeloperoxidase in cirrhosis: a possible marker of hypersplenism. (8244262)	Nakamuta M.... Nawata H.	1993	ALB

Genes related to hypersplenism according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	THPO	thrombopoietin	11.0	Publications
2	F2	coagulation factor II (thrombin)	11.0
3	EVL	Enah/Vasp-like	11.0
4	IL11	interleukin 11	11.0	Publications
5	GBA	glucosidase, beta, acid	11.0
6	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	11.0	Publications
7	TLR4	toll-like receptor 4	11.0	Publications
8	EPO	erythropoietin	11.0	Publications
9	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
10	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
11	ALB	albumin	11.0	Publications

Pathways related to hypersplenism according to GeneDecks:

(show all 23)

id	Pathway	Score	Top Affiliating Genes
1	Molecular Mechanisms of Cancer36	9.9	IL11, PIK3R1
2	Jak-STAT signaling pathway20	9.6	EPO, IL11, PIK3R1
3	Endothelin-1 Signaling Pathway36	9.4	PIK3R1, IL11, CSF3
4	Tec Kinases Signaling36	9.1	THPO, TLR4, IL11, PIK3R1
5	ERK Signaling36	9.1	CSF3, THPO, IL11, PIK3R1
6	Rheumatoid arthritis20	9.1	IL11, TLR4, CSF2
7	Amoebiasis20	8.9	PIK3R1, TLR4, CSF2
8	JAK-STAT Pathway36	8.9	EPO, THPO, F2, IL11, PIK3R1
9	Akt Signaling36	8.9	CSF2, THPO, IL11, PIK3R1
10	Cytokine production by Th17 cells in CF41	8.9	TLR4, CSF2, CSF3
11	Cytokine production by Th17 cells in CF (Mouse model)41	8.8	TLR4, CSF2, CSF3
12	RAR-Gamma-RXR-Alpha Degradation36	8.7	IL11, CSF2, CSF3
13	all-trans-Retinoic Acid Signaling in Brain36	8.6	IL11, CSF2, CSF3
14	MIF Mediated Glucocorticoid Regulation36	8.6	IL11, TLR4, CSF2, CSF3
15	IL-6 Pathway36	8.6	PIK3R1, IL11, CSF2, CSF3
16	MIF Regulation of Innate Immune Cells36	8.6	CSF3, CSF2, TLR4, IL11
17	Antioxidant Action of Vitamin-C36	8.5	IL11, THPO, CSF2, CSF3
18	p38 Signaling36	8.4	CSF3, CSF2, THPO, IL11
19	PEDF Induced Signaling36	8.4	CSF3, CSF2, IL11
20	Cytokine-cytokine receptor interaction20	8.4	EPO, CSF3, CSF2, IL11
21	PAK Pathway36	8.3	CSF3, CSF2, THPO, IL11, PIK3R1
22	Rho Family GTPases36	8.3	CSF3, CSF2, THPO, IL11, PIK3R1
23	Hematopoietic cell lineage20	8.2	IL11, THPO, CSF2, CSF3, EPO

Compounds related to hypersplenism according to GeneDecks:

(show top 50)    (show all 106)

id	Compound	Score	Top Affiliating Genes
1	etoposide32 42 9 9	13.1	PIK3R1, THPO
2	endotoxin32	10.0	CSF3
3	cyclosporin a32 42	10.8	F2, TLR4, IL11
4	cefotetan32 9 9	11.7	ALB, F2
5	mps-l32	9.6	EPO, CSF3
6	antithymoglobulin32	9.6	EPO, CSF3
7	metenolone acetate32	9.6	CSF3, EPO
8	eprex32	9.4	ALB, EPO
9	hydroxyethyl starch32	9.4	ALB, CSF3, F2
10	il 1132	9.4	CSF3, EPO, IL11
11	imatinib32 34 9 9	12.4	CSF3, THPO, PIK3R1
12	aminoguanidine32 9 9	11.3	ALB, EPO, TLR4
13	anagrelide32 9 9	11.2	EPO, CSF2, THPO
14	mafosfamide32	9.1	CSF3, CSF2, THPO
15	idarubicin32 9 9	11.0	IL11, CSF2, CSF3
16	romurtide32	9.0	CSF2, CSF3
17	methylcellulose32	8.9	CSF2, EPO, THPO, IL11
18	pegfilgrastim32 9 9	10.9	EPO, CSF3, CSF2
19	fibrinogen32	8.9	IL11, F2, ALB, TLR4, THPO
20	mycophenolate mofetil32 9 9	10.9	EPO, CSF3, IL11, ALB
21	ifosfamide32 9 9	10.8	THPO, CSF3, CSF2, IL11
22	aspirin32 34 18	10.6	THPO, TLR4, GBA, CSF2, F2
23	hyaluronic acid32 18	9.6	CSF2, F2, THPO, ALB, IL11
24	iron32 18	9.5	EPO, THPO, IL11, ALB, TLR4
25	methotrexate32 34 42 9 9	12.5	F2, ALB, CSF3, EPO, GBA
26	wortmannin32 42	9.5	PIK3R1, IL11, TLR4, CSF2, THPO
27	leucovorin32 34 9 9	11.4	CSF3, THPO, CSF2
28	fmlp32	8.4	CSF3, TLR4, THPO, CSF2
29	histamine32 18	9.4	TLR4, THPO, IL11, ALB, CSF2
30	hydroxyurea32 9 9	10.4	F2, THPO, CSF2, CSF3, EPO
31	zidovudine32 9 9	10.3	EPO, CSF3, ALB, CSF2
32	pixy32132	8.3	EPO, CSF3, CSF2, THPO, IL11
33	amifostine32 9 9	10.3	CSF3, THPO, CSF2, IL11, EPO
34	filgrastim32 9 9	10.3	CSF2, IL11, EPO, CSF3, THPO
35	arachidonic acid32 9 18 9	11.3	CSF2, ALB, THPO, IL11, TLR4
36	gm-csf32	8.3	EPO, CSF3, CSF2, THPO, IL11
37	carboplatin32 34 9 9	11.3	EPO, IL11, CSF2, THPO, CSF3
38	rantes32	8.3	CSF3, CSF2, THPO, TLR4, IL11
39	cytarabine32 34 9 9	11.3	CSF3, THPO, CSF2, EPO, IL11
40	aspartate32	8.3	IL11, PIK3R1, F2, ALB, TLR4, EPO
41	vitamin d32	8.2	IL11, ALB, TLR4, CSF2, EPO
42	heparin32 9 18 9	11.1	F2, THPO, ALB, CSF2, IL11
43	superoxide32 18	9.0	PIK3R1, CSF3, TLR4, THPO, CSF2
44	lactate32	8.0	EPO, CSF2, THPO, TLR4, ALB, F2
45	calcitriol32 42 9 18 9	11.9	EPO, CSF2, ALB, F2, IL11, TLR4
46	phosphatidylinositol32	7.9	EPO, CSF2, PIK3R1, THPO, TLR4, IL11
47	gp 13032	7.9	IL11, PIK3R1, THPO, EPO, CSF2, CSF3
48	dexamethasone32 42 34 9 9	11.8	THPO, PIK3R1, IL11, TLR4, CSF2, CSF3
49	thymidine32 18	8.5	IL11, CSF2, CSF3, EPO, GBA, PIK3R1
50	vegf32	7.4	IL11, TLR4, THPO, CSF2, CSF3, EPO

Cellular components related to hypersplenism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.1	IL11, F2, ALB, THPO, CSF2, CSF3

Biological processes related to hypersplenism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of interleukin-6 production	GO:032715	9.5	TLR4, GBA
2	response to lipopolysaccharide	GO:032496	9.2	EPO, THPO, TLR4
3	blood coagulation	GO:007596	9.0	PIK3R1, F2, ALB, THPO
4	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	8.8	CSF2, EPO
5	platelet activation	GO:030168	8.7	THPO, ALB, F2, IL11, PIK3R1
6	positive regulation of cell proliferation	GO:008284	7.7	IL11, F2, THPO, CSF2, CSF3, EPO

Molecular functions related to hypersplenism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	8.4	IL11, THPO, CSF2, CSF3
2	growth factor activity	GO:008083	7.8	IL11, F2, THPO, CSF2, CSF3