MCID: HYP063
MIFTS: 59

Hypersplenism malady

Immune diseases, Blood diseases categories
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Summaries for Hypersplenism

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Wikipedia:65 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards based summary: Hypersplenism, also known as hypersplenia, is related to portal hypertension and hepatitis. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds anagrelide and mafosfamide have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone marrow, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Hypersplenism

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Hypersplenism, Aliases & Descriptions:

Name: Hypersplenism 8 10 44 62
 
Hypersplenia 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology8 DOID:6376
ICD9CM27 289.4
MeSH34 D006971
NCIt39 C34714
ICD1025 D73.1

Related Diseases for Hypersplenism

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Diseases related to Hypersplenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension31.8EVL
2hepatitis31.2ALB, THPO, F2
3liver cirrhosis30.9F2, THPO, SERPINC1, ALB
4hepatitis c30.9TLR4, THPO, F2
5splenomegaly30.6GBA, THPO, EPO, IL2RA, CSF3
6portal vein thrombosis30.6SERPINC1, THPO, F2
7myelofibrosis30.5THPO, EPO
8arteriovenous fistula30.4EPO
9purpura30.4THPO, SERPINC1
10acquired immunodeficiency syndrome30.4CSF2, ALB, CD4
11malaria30.3ALB, CD4
12felty's syndrome30.3CSF2, CSF3
13tuberculosis30.2TLR4, IL2RA, ALB, CD4
14vascular disease30.2CD4, SERPINC1
15hepatitis b30.1F2, TLR4, ALB, CD4
16polycythemia30.0THPO, EPO
17arthritis29.9CD4, ALB, CSF2, FOXP3, TLR4
18t-cell leukemia29.8RELA, REL, FOXP3, IL2RA, CD4
19pancytopenia29.8GBA, THPO, EPO, IL2RA, CSF2, CSF3
20stomatitis29.6CSF3, CSF2
21neutropenia29.6THPO, EPO, CSF2, CSF3
22acute leukemia29.6CSF3, CSF2, EPO, THPO
23hodgkin's lymphoma29.5PIK3R1, REL, IL2RA, CSF2, CSF3
24liver cancer29.5F2, PIK3R1, TLR4, FOXP3, ALB, CD4
25thrombocytopenia29.1CD4, ALB, CSF3, CSF2, EPO, SERPINC1
26leukemia28.5GBA, PIK3R1, THPO, TLR4, EPO, REL
27hypertension10.7
28capillary leak syndrome10.6CSF2
29autoimmune thrombocytopenic purpura10.6THPO
30hydrops fetalis10.5GBA
31cryptosporidiosis10.5CD4
32sneddon syndrome10.5SERPINC1
33factor xii deficiency10.5SERPINC1
34cryptococcosis10.5CD4
35hepatocellular carcinoma10.5
36pyelonephritis10.4TLR4
37bernard-soulier syndrome10.4F2, THPO
38dysfibrinogenemia10.4SERPINC1, F2
39prothrombin deficiency10.4F2, SERPINC1
405q- syndrome10.4EPO
41megakaryocytic leukemia10.4THPO, CSF2
42antithrombin iii deficiency10.4F2, SERPINC1
43protein s deficiency10.4SERPINC1, F2
44hemorrhagic disease10.4F2, SERPINC1
45tropical spastic paraparesis10.4FOXP3, IL2RA
46placental abruption10.4F2, SERPINC1
47esophageal varix10.4F2, ALB
48factor vii deficiency10.4F2, SERPINC1
49histoplasmosis10.4REL, RELA
50autoimmune lymphoproliferative syndrome10.4IL2RA, CD4

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to hypersplenism

Symptoms for Hypersplenism

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Drugs & Therapeutics for Hypersplenism

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Drug clinical trials:

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Genetic Tests for Hypersplenism

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Anatomical Context for Hypersplenism

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MalaCards organs/tissues related to Hypersplenism:

32
Spleen, Liver, Bone marrow, Bone, T cells, Myeloid, Testes, B cells, Pineal, Brain, Pancreas, Breast

Animal Models for Hypersplenism or affiliated genes

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Publications for Hypersplenism

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Articles related to Hypersplenism:

(show top 50)    (show all 429)
idTitleAuthorsYear
1
A novel method for laparoscopic splenectomy in the setting of hypersplenism secondary to liver cirrhosis: ten years' experience. (24867471)
2014
2
Opportunistic Fonsecaea pedrosoi brain abscess in a patient with non-cirrhotic portal fibrosis-induced hypersplenism--a novel association. (23458558)
2013
3
Prophylaxis against hepatitis B virus recurrence after liver transplantation for hepatitis B virus-related end-stage liver diseases with severe hypersplenism and splenomegaly: role of splenectomy. (22483806)
2012
4
Partial splenic embolization using Bletilla striata particles for hypersplenism in cirrhosis: a prospective study. (21476204)
2011
5
Total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism. (21734807)
2011
6
Partial splenic embolization as an alternative to splenectomy in hypersplenism--single center experience in 16 years. (20862632)
2010
7
Hypersplenism caused by an accessory spleen mimicking an intra-abdominal neoplasm: report of a case. (19779782)
2009
8
Portal hypertension and hypersplenism in a patient with a Bochdalek hernia: a case report. (18398560)
2009
9
Two-year follow-up of splenic radiofrequency ablation in patients with cirrhotic hypersplenism: does increased hepatic arterial flow induce liver regeneration? (18374048)
2008
10
Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. (19039645)
2008
11
Congenital absence of the portal vein with splenomegaly and hypersplenism in a young woman. (12743449)
2003
12
Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. (12753144)
2003
13
Acute hypersplenism with splenomegaly after portal vein embolization. (12075192)
2002
14
Interleukin-11 administration normalizes the platelet count in a hypersplenic cirrhotic patient. (12424546)
2002
15
The first experience with non-operative treatment of hypersplenism in children with portal hypertension. (12469254)
2002
16
Partial splenic embolization for hypersplenism before and after liver transplantation. (12372046)
2002
17
Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome. (11170921)
2001
18
Hypersplenism. (11338057)
2001
19
Locoregional intrasplenic chemotherapy for hypersplenism in myelofibrosis. (11552991)
2001
20
Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. (11139352)
2000
21
Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis. (8946990)
1996
22
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism...". (8855767)
1996
23
Partial splenic embolisation and improvement of hypersplenism before liver transplantation. (7741576)
1995
24
Hypersplenism in liver cirrhosis: is conservative treatment still best? (8857456)
1995
25
Splenic ablation by percutaneous injection of ethanolamine oleate in dogs: a possible therapy for hypersplenism. (2606310)
1989
26
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
27
Hypersplenism secondary to a ruptured gallbladder and a pericholecystic abscess that presented as staphylococcal septicemia. (3949560)
1986
28
Computed tomography follow-up of nonsurgical treatment for hypersplenism. (3731807)
1986
29
Clinical disorders of splenic function: the spectrum from asplenism to hypersplenism. (6887967)
1983
30
Splenic embolization in a child with hypersplenism. (7161676)
1982
31
Partial splenic embolization in the management of hypersplenism secondary to Gaucher disease. (7131151)
1982
32
Isoniazid-related liver disease. Occurrence with portal hypertension, hypoalbuminemia, and hypersplenism. (448941)
1979
33
Splenectomy for hypersplenism. (707906)
1978
34
Control of hypersplenism and painful splenomegaly in myeloid metaplasia by irradiation. (413815)
1977
35
Hypersplenism in Hodgkin's disease: a report of three cases presenting with cytopenias. (593655)
1977
36
Experimental hypersplenism in mice. (131348)
1976
37
Partial splenectomy and pleural splenic transposition, a new approach to congestive hypersplenism of portal hypertension. (5037265)
1972
38
The kinetics of plaque-forming cells in experimental hypersplenism. (4999135)
1971
39
HYPERSPLENISM IN SICKLE CELL ANEMIA. (14170620)
1964
40
Hypersplenism. (13749081)
1961
41
Hypersplenism due to infection. A study of five cases manifesting hemolytic anemia. (13789380)
1961
42
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
43
Hypersplenism. (13230762)
1955
44
Secondary hypersplenism with recurrent gastrointestinal bleeding. (13059633)
1953
45
Surgical aspects of hypersplenism. (13036936)
1953
46
Pancreatic cyst; an unusual cause of hypersplenism. (12996227)
1952
47
Hypersplenism. (14863408)
1951
48
The use of ACTH in hypersplenism. (14931201)
1951
49
Hypersplenism in a patient with lymphogranuloma benignum. (15391143)
1949
50
The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. (21013546)
1946

Variations for Hypersplenism

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Expression for genes affiliated with Hypersplenism

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Expression patterns in normal tissues for genes affiliated with Hypersplenism

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Pathways for genes affiliated with Hypersplenism

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Pathways related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.6FOXP3, IL2RA, CSF2
2
Show member pathways
9.6FOXP3, IL2RA, CSF2
3
Show member pathways
9.5CD4, IL2RA, PIK3R1
4
Show member pathways
9.4F2, PIK3R1, THPO, IL2RA
59.4CD4, CSF3, CSF2
69.1IL7R, IL2RA, RELA
7
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.1PIK3R1, RELA, REL
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.1REL, RELA, PIK3R1
99.1REL, RELA, PIK3R1
109.1REL, RELA, PIK3R1
11
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1REL, RELA, PIK3R1
12
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.1REL, RELA, PIK3R1
13
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.1REL, RELA, PIK3R1
149.0TLR4, RELA, REL
15
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0REL, RELA, TLR4
169.0PIK3R1, RELA, CSF2
17
Show member pathways
9.0IL2RA, RELA, PIK3R1
18
Show member pathways
8.9CSF2, RELA, TLR4
19
Show member pathways
thioredoxin pathway37
8.9F2, RELA, ALB
20
Show member pathways
8.9PIK3R1, TLR4, RELA
21
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.8RELA, REL, IL2RA, CD4
22
Show member pathways
8.8F2, PIK3R1, THPO, SERPINC1, ALB
23
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.8PIK3R1, RELA, REL, CD4
24
Show member pathways
8.8CD4, REL, RELA, PIK3R1
25
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.8CSF2, REL, RELA, PIK3R1
26
Show member pathways
Immune response IL 3 activation and signaling pathway60
8.8PIK3R1, RELA, REL, IL2RA
27
Show member pathways
IL2 signaling events mediated by STAT537
8.7IL2RA, FOXP3, RELA, PIK3R1
288.7PIK3R1, RELA, IL2RA, CSF2
29
Show member pathways
8.7PIK3R1, TLR4, RELA, FOXP3
308.6PIK3R1, TLR4, RELA, CSF2
31
Show member pathways
8.6PIK3R1, TLR4, RELA, IL2RA
32
Show member pathways
8.6IL2RA, RELA, TLR4, PIK3R1
33
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6F2, PIK3R1, RELA, REL, CD4
34
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.5PIK3R1, THPO, RELA, IL2RA, IL7R
35
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.5PIK3R1, RELA, REL, CSF2, CD4
36
Show member pathways
8.5PIK3R1, THPO, TLR4, RELA, REL
378.4RELA, EPO, TLR4, PIK3R1
38
Show member pathways
8.4PIK3R1, RELA, IL2RA, IL7R, CSF2
39
Show member pathways
8.4PIK3R1, RELA, IL2RA, IL7R, CSF2
40
Show member pathways
8.4CD4, EVL, RELA, PIK3R1
41
Show member pathways
8.4F2, PIK3R1, THPO, EPO, IL2RA, IL7R
42
Show member pathways
Type III interferon signaling37
8.3PIK3R1, EPO, IL2RA, IL7R, CSF2, CSF3
43
Show member pathways
8.2PIK3R1, THPO, IL2RA, IL7R, CSF2, CSF3
44
Show member pathways
8.2PIK3R1, THPO, IL2RA, IL7R, CSF2, CSF3
45
Show member pathways
8.2CD4, EVL, REL, RELA, PIK3R1
468.1CD4, THPO, EPO, IL2RA, IL7R, CSF2
47
Show member pathways
7.9TLR4, RELA, REL, FOXP3, CSF2, CSF3
48
Show member pathways
7.8PIK3R1, THPO, TLR4, IL2RA, IL7R, CSF2
497.3PIK3R1, TLR4, EPO, RELA, IL2RA, IL7R
50
Show member pathways
6.5F2, PIK3R1, TLR4, EPO, RELA, IL2RA

Compounds for genes affiliated with Hypersplenism

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Compounds related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1anagrelide44 1110.9THPO, CSF2, EPO
2mafosfamide449.8CSF3, THPO, CSF2
3hepaplastin449.7SERPINC1, ALB, F2
4tranexamic acid44 1110.7F2, EPO, SERPINC1
5phenprocoumon44 50 1111.7F2, SERPINC1, ALB
6pegfilgrastim44 1110.6CSF2, CSF3, EPO
7epsilon aminocaproic acid449.4SERPINC1, F2, EPO
8pixy321449.4CSF3, EPO, THPO, CSF2
9amifostine44 1110.4CSF3, EPO, THPO, CSF2
10filgrastim44 1110.4THPO, CSF2, CSF3, EPO
11gm-csf44 2810.4THPO, EPO, CSF2, CSF3
12anti-fungal449.4CSF3, CSF2, TLR4, REL
13methylcellulose449.4CSF3, CSF2, THPO, EPO
14polyethylene glycol449.4SERPINC1, F2, THPO, ALB
15chloroquine44 2 50 28 1113.3SERPINC1, TLR4, CD4, IL2RA
16hydroxyethyl starch449.3SERPINC1, CSF3, F2, ALB
17carboplatin44 50 1111.2EPO, CSF3, CSF2, THPO
18hydroxyurea44 50 1111.2CSF3, F2, CSF2, THPO, EPO
19bleomycin44 1110.2CSF2, EPO, IL2RA, CSF3
20etoposide44 50 61 1112.0PIK3R1, IL2RA, CSF2, CSF3, THPO
21mycophenolate mofetil44 50 1111.0ALB, CSF3, EPO, IL2RA
22aminoguanidine44 28 1111.0TLR4, EPO, ALB
23genistein44 28 61 2 24 1114.0PIK3R1, IL2RA, TLR4, CSF2, THPO, CD4
24pge2448.9CSF2, FOXP3, TLR4, SERPINC1, IL2RA, CD4
25fibrinogen448.9ALB, SERPINC1, TLR4, THPO, F2
26aspirin44 50 28 2411.8GBA, F2, THPO, TLR4, SERPINC1, IL2RA
27zidovudine44 50 1110.8CD4, ALB, CSF2, EPO, CSF3
28imatinib44 50 1110.8THPO, PIK3R1, EPO, CSF3, ALB
29polysaccharide448.7TLR4, THPO, SERPINC1, CSF2, GBA, IL2RA
30estrogen448.7CSF2, PIK3R1, IL2RA, F2, THPO, SERPINC1
31histamine44 28 2410.7THPO, TLR4, IL2RA, ALB, CSF2
32lactate448.7ALB, EPO, F2, TLR4, THPO, CSF2
33creatinine448.7F2, IL2RA, SERPINC1, EPO, ALB, THPO
34calcitriol44 61 24 1111.7CSF2, IL2RA, EPO, TLR4, F2, ALB
35rantes448.6CD4, CSF3, CSF2, REL, THPO, IL2RA
36vitamin d448.6ALB, TLR4, EPO, CSF2, IL2RA
37phospholipid448.6PIK3R1, IL2RA, TLR4, GBA, F2
38gp 130448.5CSF3, CSF2, IL7R, PIK3R1, THPO, EPO
39aspartate448.5EPO, ALB, IL2RA, TLR4, PIK3R1, F2
40thymidine44 249.5PIK3R1, GBA, IL2RA, CSF2, EPO, CSF3
41heparin44 28 24 1111.4THPO, CSF2, IL7R, IL2RA, SERPINC1, F2
42cysteine448.3CSF2, ALB, CD4, IL2RA, REL, TLR4
43phosphatidylinositol448.3CD4, CSF2, IL7R, IL2RA, EPO, THPO
44cyclosporin a44 28 6110.2F2, REL, FOXP3, IL2RA, CSF2, CSF3
45methotrexate50 44 1110.2F2, TLR4, EPO, IL2RA, ALB, CSF3
46dexamethasone44 50 28 1111.2CSF2, REL, CSF3, SERPINC1, IL2RA, TLR4
47vegf448.0THPO, PIK3R1, CSF3, TLR4, SERPINC1, EPO
48testosterone44 61 24 1110.7EPO, IL2RA, ALB, PIK3R1, SERPINC1, RELA
49serine447.7PIK3R1, RELA, F2, GBA, CD4, REL
50tyrosine447.6EPO, REL, IL2RA, IL7R, CSF2, CD4

GO Terms for genes affiliated with Hypersplenism

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Cellular components related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4ALB, SERPINC1, F2
2external side of plasma membraneGO:0098979.1TLR4, IL2RA, IL7R, CD4
3extracellular regionGO:0055768.0F2, SERPINC1, EPO, IL7R, CSF2, ALB
4extracellular spaceGO:0056157.9ALB, CSF3, CSF2, EPO, SERPINC1, THPO

Biological processes related to Hypersplenism according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immune responseGO:05077710.1FOXP3, IL2RA
2cytokine productionGO:00181610.0REL, FOXP3, CD4
3macrophage activationGO:04211610.0TLR4, CSF2
4negative regulation of neuron deathGO:19012159.9CSF3, REL
5negative regulation of interleukin-6 productionGO:0327159.9FOXP3, TLR4, GBA
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9CSF2, EPO
7negative regulation of osteoclast differentiationGO:0456719.8TLR4, PIK3R1
8negative regulation of interferon-gamma productionGO:0326899.8FOXP3, TLR4
9negative regulation of inflammatory responseGO:0507289.8IL2RA, SERPINC1, GBA
10response to testosteroneGO:0335749.7EPO, GBA
11defense response to Gram-negative bacteriumGO:0508299.5CD4, TLR4
12platelet activationGO:0301689.4F2, PIK3R1, THPO, ALB
13positive regulation of interleukin-12 biosynthetic processGO:0450849.4TLR4, RELA, REL
14cell surface receptor signaling pathwayGO:0071669.1CD4, EVL, IL7R, IL2RA, F2
15T cell receptor signaling pathwayGO:0508529.1PIK3R1, RELA, FOXP3, CD4
16blood coagulationGO:0075969.1F2, PIK3R1, THPO, SERPINC1, ALB
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1TLR4, RELA, REL
18cellular response to lipopolysaccharideGO:0712228.7TLR4, RELA, CSF2, CSF3
19immune responseGO:0069558.7CD4, CSF3, CSF2, IL7R, IL2RA, TLR4
20positive regulation of transcription, DNA-templatedGO:0458938.7EPO, RELA, REL, FOXP3
21positive regulation of cell proliferationGO:0082848.4CSF3, CSF2, RELA, EPO, F2
22positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CSF3, FOXP3, RELA, TLR4, PIK3R1

Molecular functions related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NF-kappaB bindingGO:0510599.4FOXP3, RELA
2cytokine activityGO:0051259.1CSF3, CSF2, THPO
3growth factor activityGO:0080839.1F2, THPO, CSF2, CSF3
4protein bindingGO:0055155.1CD4, GBA, F2, PIK3R1, TLR4, SERPINC1

Products for genes affiliated with Hypersplenism

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Sources for Hypersplenism

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3CDC
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25ICD10
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27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
43NINDS
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