MCID: HYP063
MIFTS: 48

Hypersplenism malady

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Hypersplenism

Aliases & Descriptions for Hypersplenism:

Name: Hypersplenism 12 52 42 14 69
Hypersplenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6376
ICD10 33 D73.1
ICD9CM 35 289.4
MeSH 42 D006971
NCIt 47 C34714
UMLS 69 C0020532

Summaries for Hypersplenism

MalaCards based summary : Hypersplenism, also known as hypersplenia, is related to splenomegaly and nondystrophic myotonia, and has symptoms including hepatosplenomegaly An important gene associated with Hypersplenism is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Heparin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 71 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

Related Diseases for Hypersplenism

Diseases related to Hypersplenism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
id Related Disease Score Top Affiliating Genes
1 splenomegaly 11.2
2 nondystrophic myotonia 10.3 ALB F2
3 pharynx carcinoma in situ 10.3 ALB F2
4 female infertility of uterine origin 10.3 ALB F2
5 bile duct cystadenocarcinoma 10.3 ALB F2
6 portal hypertension 10.2
7 vascular erectile tumor 10.2 F2 SERPINC1
8 subungual glomus tumor 10.2 FOXP3 IFNG
9 miller-dieker lissencephaly syndrome 10.2 F2 SERPINC1
10 influenza 10.2 F2 SERPINC1
11 pancreatic ductal carcinoma 10.2 F2 SERPINC1
12 duane retraction syndrome 10.2 ALB F2
13 mixed epithelial tumor of ovary 10.2 F2 SERPINC1
14 chorioretinal scar 10.2 F2 SERPINC1
15 mixed hepatoblastoma 10.2 F2 SERPINC1
16 peanut allergy 10.2 F2 SERPINC1
17 may-hegglin anomaly 10.2 F2 SERPINC1
18 cataract 10.2 ALB SERPINC1
19 left-right axis malformations 10.2 F2 SERPINC1
20 lymphocytic colitis 10.2 F2 SERPINC1
21 dmd-related dilated cardiomyopathy 10.2 F2 SERPINC1
22 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.2 ALB EPO F2
23 spinal cord lipoma 10.2 F2 SERPINC1
24 benign deep fibrous histiocytoma 10.2 ALB F2 IFNG
25 depressed scar 10.2 ALB F2 IFNG
26 myoglobinuria recurrent 10.2 IFNG IL4
27 sclerosing adenosis of breast 10.2 ALB F2 IFNG
28 hepatocellular carcinoma 10.2
29 asymptomatic neurosyphilis 10.2 IFNG IL4
30 poems syndrome 10.2 EPO THPO
31 autosomal dominant deafness-onychodystrophy syndrome 10.1 IFNG IL4
32 freiberg's disease 10.1 ALB F2 SERPINC1
33 midline cystocele 10.1 F2 SERPINC1
34 angelucci's syndrome 10.1 ALB F2 SERPINC1
35 eagle syndrome 10.1 ALB F2 SERPINC1
36 alcoholic gastritis 10.1 ALB F2 SERPINC1
37 ischemic optic neuropathy 10.1 ALB F2 SERPINC1
38 leukocyte disease 10.1 ALB F2 SERPINC1
39 asbestosis 10.1 ALB F2 SERPINC1
40 fibrosclerosis of breast 10.1 EPO IL4
41 congenital chloride diarrhea 10.1 ALB F2 SERPINC1
42 obstructive jaundice 10.1 ALB F2 SERPINC1
43 liver cirrhosis 10.1
44 thrombocytopenia 10.1
45 tungiasis 10.1 IFNG IL4
46 uterine ligament clear cell adenocarcinoma 10.1 ALB FOXP3 IFNG
47 crustacean allergy 10.1 IFNG IL4
48 chronic inflammatory demyelinating polyneuritis 10.1 ALB F2 THPO
49 schwannoma of jugular foramen 10.1 F2 SERPINC1
50 papillary squamous carcinoma 10.1 FOXP3 IL4

Comorbidity relations with Hypersplenism via Phenotypic Disease Network (PDN): (show all 12)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Alcoholic Liver Cirrhosis
Chronic Congestive Splenomegaly Deficiency Anemia
Heart Disease Hepatic Encephalopathy
Iron Deficiency Anemia Neutropenia
Portal Hypertension Primary Thrombocytopenia

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to Hypersplenism

Symptoms & Phenotypes for Hypersplenism

UMLS symptoms related to Hypersplenism:


hepatosplenomegaly

MGI Mouse Phenotypes related to Hypersplenism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 FOXP3 IFNG IL4 PIK3R1 SERPINC1 THPO
2 hematopoietic system MP:0005397 10.09 SERPINC1 THPO CD4 EPO F2 FOXP3
3 immune system MP:0005387 10.02 CD4 EPO F2 FOXP3 IFNG IL4
4 digestive/alimentary MP:0005381 9.93 ALB CD4 F2 FOXP3 IFNG IL4
5 mortality/aging MP:0010768 9.81 ALB CD4 EPO F2 FOXP3 IFNG
6 integument MP:0010771 9.8 F2 FOXP3 IFNG IL4 CD4 EPO
7 liver/biliary system MP:0005370 9.8 ALB EPO FOXP3 IFNG IL4 PIK3R1
8 normal MP:0002873 9.56 ALB CD4 EPO F2 FOXP3 IFNG
9 renal/urinary system MP:0005367 9.02 ALB FOXP3 IFNG IL4 SERPINC1

Drugs & Therapeutics for Hypersplenism

Drugs for Hypersplenism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Dipyridamole Approved Phase 4 58-32-2 3108
4
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
5
Warfarin Approved Phase 4 81-81-2 6691 54678486
6 Nadroparin Approved Phase 4 9041-08-1
7
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
8
Dalteparin Approved Phase 4 9041-08-1
9 tannic acid Approved, Nutraceutical Phase 4
10 Liver Extracts Phase 4,Phase 2,Phase 3
11 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
12 calcium heparin Phase 4
13 Analgesics Phase 4
14 Adrenergic Agents Phase 4
15 Adrenergic Antagonists Phase 4
16 Adrenergic alpha-1 Receptor Antagonists Phase 4
17 Adrenergic alpha-Antagonists Phase 4
18 Adrenergic beta-Antagonists Phase 4
19 Cyclooxygenase Inhibitors Phase 4
20 Heparin, Low-Molecular-Weight Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Peripheral Nervous System Agents Phase 4
23 Vasodilator Agents Phase 4
24 Phosphodiesterase Inhibitors Phase 4
25 Platelet Aggregation Inhibitors Phase 4
26 Fibrinolytic Agents Phase 4
27 Anticoagulants Phase 4
28 Anti-Inflammatory Agents Phase 4
29 Antihypertensive Agents Phase 4
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4
31 Antipyretics Phase 4
32 Antirheumatic Agents Phase 4
33 Calcium, Dietary Phase 4
34
Valproic Acid Approved, Investigational Phase 1, Phase 2 99-66-1 3121
35
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
36 Tegafur Approved Phase 2 17902-23-7
37
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
38
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
39
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
40 GABA Agents Phase 1, Phase 2
41 Tranquilizing Agents Phase 1, Phase 2
42 Anticonvulsants Phase 1, Phase 2
43 Psychotropic Drugs Phase 1, Phase 2
44 Antimanic Agents Phase 1, Phase 2
45 Central Nervous System Depressants Phase 1, Phase 2
46 Nicotinic Acids Phase 2
47 Trace Elements Phase 2
48 Vitamin B Complex Phase 2
49 Vitamins Phase 2
50 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy Recruiting NCT02238444 Phase 4
2 Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS Recruiting NCT02925975 Phase 4
3 ABMSC Infusion Through Hepatic Artery in Portal Hypertension Surgery for the Treatment of Liver Cirrhosis Unknown status NCT01560845 Phase 2, Phase 3
4 Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Completed NCT00605657 Phase 1, Phase 2
5 Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACE Terminated NCT01539018 Phase 2
6 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584
7 Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis Unknown status NCT01201655
8 Treatment of Portal Vein Tumor Thrombus After Hepatocellular Carcinoma Resection Completed NCT00825669
9 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
10 The Treatment of Hepatocirrhosis and Portal Hypertension Recruiting NCT02778425
11 The Natural History and Prognostic Factors of Compensated Cirrhosis. Recruiting NCT03144700

Search NIH Clinical Center for Hypersplenism

Cochrane evidence based reviews: hypersplenism

Genetic Tests for Hypersplenism

Anatomical Context for Hypersplenism

MalaCards organs/tissues related to Hypersplenism:

39
Spleen, Liver, Bone, Bone Marrow, T Cells, Myeloid, Testes

Publications for Hypersplenism

Articles related to Hypersplenism:

(show top 50) (show all 481)
id Title Authors Year
1
Laparoscopic splenic artery ligation for hypersplenism in cirrhosis: A case series. ( 27251809 )
2016
2
Hypersplenism Associated With Late-Presenting Congenital Diaphragmatic Hernia: A Rare Combination. Case Report. ( 27227931 )
2016
3
Laparoscopic versus traditional open splenectomy for hepatocellular carcinoma with hypersplenism. ( 27465326 )
2016
4
Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism. ( 27393102 )
2016
5
A Comparative Study of Surgical Splenectomy, Partial Splenic Embolization, and High-Intensity Focused Ultrasound for Hypersplenism. ( 26839374 )
2016
6
Dameshek W, Miller EB. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. 1946. ( 26744432 )
2016
7
Influence of lactulose on interventional therapy for HCC patients with hepatocirrhosis and hypersplenism. ( 26919955 )
2016
8
Severe hypersplenism associated to hemophagocytic and lymphoproliferative syndrome secondary to Epstein-Barr virus infection. A report of two cases. ( 27041246 )
2016
9
Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process. ( 26865982 )
2016
10
Hypersplenism: History and current status. ( 27703501 )
2016
11
Treatment of Hypersplenism by Partial Splenic Embolization Through Gastric Collaterals. ( 27200164 )
2016
12
Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension. ( 27006743 )
2016
13
Pancreatic fistula after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis: effect of fibrin glue and polyglycolic acid felt on prophylaxis of postoperative complications. ( 27162072 )
2016
14
Erratum to: Hypersplenism is correlated with increased risk of hepatocellular carcinoma in patients with post-hepatitis cirrhosis. ( 27146644 )
2016
15
Risk Factors for Portal Vein System Thrombosis After Laparoscopic Splenectomy in Cirrhotic Patients with Hypersplenism. ( 26953863 )
2016
16
Simultaneous microwave coagulo-necrotic therapy (MCN) and laparoscopic splenectomy for the treatment of hepatocellular carcinoma with cirrhotic hypersplenism. ( 27577937 )
2016
17
Partial Splenic Embolization in a Child with Sickle Cell Disease and Hypersplenism. ( 27926404 )
2016
18
Hepatocellular Carcinoma with Hypersplenic Thrombocytopenia and Situs Inversus Totalis: A Case Report. ( 28031104 )
2016
19
Laparoscopic Splenectomy for the Elderly Liver Cirrhotic Patients With Hypersplenism: A Retrospective Comparable Study. ( 26962816 )
2016
20
Hypersplenism is correlated with increased risk of hepatocellular carcinoma in patients with post-hepatitis cirrhosis. ( 26753954 )
2016
21
Percutaneous Microwave Ablation in the Spleen for Treatment of Hypersplenism in Cirrhosis Patients. ( 26031423 )
2015
22
Partial splenic embolization of patients with hypersplenism by transradial or transfemoral approach: a prospective randomized controlled trial. ( 26671306 )
2015
23
Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option. ( 26034376 )
2015
24
Partial Splenic Artery Embolization for the Management of Hypersplenism in Cirrhosis. ( 26388645 )
2015
25
Partial embolization as re-treatment of hypersplenism after unsuccessful splenic artery ligation. ( 25632215 )
2015
26
Hypersplenism: an independent risk factor for myocardial remodeling in chronic heart failure patients. ( 26131093 )
2015
27
Anaesthetic management of beta thalassemia major with hypersplenism for splenectomy in pediatric age group: Report of four cases. ( 26417142 )
2015
28
Laparoscopic splenic vessels ligation as a treatment of hypersplenism and thrombocytopenia in children. ( 26659241 )
2015
29
An innovative modification of sandwich embolization technique for simultaneous management of ruptured pseudoaneurysm of branch of splenic artery and hypersplenism syndrome. ( 25900542 )
2015
30
Successful Splenectomy for Hypersplenism in Wilson's Disease: A Single Center Experience from China. ( 25910248 )
2015
31
Simultaneous hepatectomy and splenectomy versus hepatectomy alone for hepatocellular carcinoma complicated by hypersplenism: a meta-analysis. ( 26316782 )
2015
32
Comparison of two laparoscopic splenectomy plus pericardial devascularization techniques for management of portal hypertension and hypersplenism. ( 25783835 )
2015
33
Splenectomy Followed by Hepatectomy for Hepatocellular Carcinoma with Hypersplenism and Portal Hypertension Caused by Macroglobulinemia. ( 26124358 )
2015
34
Laparoscopic surgery is more advantageous than laparotomic surgery for treatment of hypersplenism with gallstones. ( 26091138 )
2015
35
Microwave Ablation for the Treatment of Hypersplenism: Short Waves, Low Cost, Big Results. ( 26541991 )
2015
36
Isolated Splenic Vein Thrombosis: 8-Year-Old Boy with Massive Upper Gastrointestinal Bleeding and Hypersplenism. ( 26345989 )
2015
37
Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study. ( 25741142 )
2015
38
Portal and splanchnic hemodynamics after partialA splenic embolization in cirrhotic patients with hypersplenism. ( 26547369 )
2015
39
Splenectomy attenuates murine liver fibrosis with hypersplenism stimulating hepatic accumulation of Ly-6C(lo) macrophages. ( 26022691 )
2015
40
Percutaneous transhepatic embolization of gastroesophageal varices combined with partial splenic embolization for the treatment of variceal bleeding and hypersplenism. ( 26770628 )
2015
41
Can hypersplenism secondary to portal hypertension be treated by non-selective beta blockers? ( 25788189 )
2015
42
Thrombocytopenia due to hypersplenism in oncological disease: Partial splenic embolization during palliative treatment. ( 25737395 )
2015
43
Hypersplenism Treated by Partial Splenic Embolization Using Guglielmi Detachable Coils. ( 26328643 )
2015
44
Utility of Partial Splenic Embolization for Hypersplenism using Guglielmi Detachable Coils. ( 26897954 )
2015
45
Splenectomy as a measure to treat prolonged post-transplant cytopenia associated with hypersplenism. ( 24442253 )
2014
46
Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria. ( 24673826 )
2014
47
The selection of surgical treatment for gastric cancer patients with cirrhosis and hypersplenism. ( 24895827 )
2014
48
Synchronous splenectomy and hepatectomy in patients with hepatocellular carcinoma, hypersplenism and liver cirrhosis. ( 25513097 )
2014
49
A novel method for laparoscopic splenectomy in the setting of hypersplenism secondary to liver cirrhosis: ten years' experience. ( 24867471 )
2014
50
Laparoscopic splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension. ( 24914339 )
2014

Variations for Hypersplenism

Expression for Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

Pathways for Hypersplenism

Pathways related to Hypersplenism according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 CD4 EPO F2 IFNG IL4 PIK3R1
2
Show member pathways
13.18 CD4 EPO F2 IFNG IL4 PIK3R1
3
Show member pathways
13.09 ALB F2 PIK3R1 SERPINC1 THPO
4
Show member pathways
12.63 CD4 FOXP3 IFNG IL4
5
Show member pathways
12.43 CD4 IFNG IL4 PIK3R1
6
Show member pathways
12.39 CD4 FOXP3 IFNG IL4
7
Show member pathways
12.36 CD4 F2 IFNG PIK3R1
8
Show member pathways
12.17 CD4 IFNG IL4 PIK3R1
9
Show member pathways
12 ALB F2 IFNG IL4
10
Show member pathways
11.8 CD4 IFNG IL4
11
Show member pathways
11.79 EPO IFNG IL4 PIK3R1 THPO
12
Show member pathways
11.74 CD4 IFNG IL4
13 11.71 EPO IFNG PIK3R1
14 11.59 CD4 IFNG IL4
15
Show member pathways
11.55 FOXP3 IFNG IL4
16 11.54 CD4 EPO IL4 THPO
17
Show member pathways
11.44 FOXP3 IL4 PIK3R1
18 11.15 IFNG IL4
19 11.13 IFNG IL4
20 11.09 CD4 EPO IFNG IL4 THPO
21 11.06 CD4 IFNG
22 11.02 IFNG IL4
23 11 F2 IFNG
24 10.97 CD4 IFNG IL4
25 10.93 IFNG PIK3R1
26 10.93 CD4 FOXP3 IFNG IL4

GO Terms for Hypersplenism

Cellular components related to Hypersplenism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ALB EPO F2 IFNG IL4 SERPINC1
2 blood microparticle GO:0072562 9.5 ALB F2 SERPINC1
3 endoplasmic reticulum lumen GO:0005788 9.46 ALB CD4 F2 SERPINC1
4 external side of plasma membrane GO:0009897 9.26 CD4 F2 IFNG IL4
5 extracellular space GO:0005615 9.17 ALB EPO F2 IFNG IL4 SERPINC1

Biological processes related to Hypersplenism according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.88 ALB EPO IL4 PIK3R1
2 positive regulation of cell proliferation GO:0008284 9.87 EPO F2 IFNG IL4
3 positive regulation of transcription, DNA-templated GO:0045893 9.8 CD4 EPO FOXP3 IFNG IL4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 CD4 EPO THPO
5 response to nutrient GO:0007584 9.63 EPO IL4 SERPINC1
6 positive regulation of establishment of protein localization to plasma membrane GO:0090004 9.61 IFNG PIK3R1
7 positive regulation of activated T cell proliferation GO:0042104 9.6 EPO IL4
8 cytokine production GO:0001816 9.58 CD4 FOXP3
9 negative regulation of osteoclast differentiation GO:0045671 9.56 IL4 PIK3R1
10 regulation of blood coagulation GO:0030193 9.55 F2 SERPINC1
11 defense response to protozoan GO:0042832 9.54 IFNG IL4
12 positive regulation of T cell proliferation GO:0042102 9.54 CD4 IFNG IL4
13 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.52 EPO IL4
14 negative regulation of interleukin-17 production GO:0032700 9.51 FOXP3 IFNG
15 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IFNG IL4
16 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 IFNG IL4
17 positive regulation of MHC class II biosynthetic process GO:0045348 9.43 IFNG IL4
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 EPO IFNG IL4
19 negative regulation of T-helper 17 cell differentiation GO:2000320 9.32 FOXP3 IL4
20 negative regulation of chronic inflammatory response GO:0002677 9.26 FOXP3 IL4
21 T cell receptor signaling pathway GO:0050852 9.26 CD4 FOXP3 IFNG PIK3R1
22 positive regulation of protein phosphorylation GO:0001934 9.02 CD4 F2 IFNG IL4 THPO

Molecular functions related to Hypersplenism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IFNG IL4 THPO
2 growth factor activity GO:0008083 8.8 F2 IL4 THPO

Sources for Hypersplenism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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