MCID: HYP063
MIFTS: 58

Hypersplenism malady

Immune diseases, Blood diseases categories

Summaries for Hypersplenism

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Wikipedia:64 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards based summary: Hypersplenism, also known as hypersplenia, is related to portal hypertension and hepatitis. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds anagrelide and mafosfamide have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone marrow, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Hypersplenism

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS, 28ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 26ICD10
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Hypersplenism, Aliases & Descriptions:

Name: Hypersplenism 9 11 44 61
 
Hypersplenia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:6376
ICD9CM28 289.4
MeSH34 D006971
NCIt39 C34714
ICD1026 D73.1

Related Diseases for Hypersplenism

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Diseases related to Hypersplenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension31.8EVL
2hepatitis31.2F2, THPO, ALB
3liver cirrhosis30.9F2, ALB, SERPINC1, THPO
4hepatitis c30.9THPO, F2, TLR4
5splenomegaly30.6IL2RA, EPO, THPO, GBA, CSF3
6portal vein thrombosis30.6THPO, SERPINC1, F2
7myelofibrosis30.5EPO, THPO
8arteriovenous fistula30.4EPO
9purpura30.4THPO, SERPINC1
10acquired immunodeficiency syndrome30.4CD4, CSF2, ALB
11malaria30.3CD4, ALB
12felty's syndrome30.3CSF3, CSF2
13tuberculosis30.2ALB, CD4, TLR4, IL2RA
14vascular disease30.2SERPINC1, CD4
15hepatitis b30.1ALB, F2, TLR4, CD4
16polycythemia30.1EPO, THPO
17arthritis29.9ALB, CD4, CSF2, TLR4, FOXP3
18t-cell leukemia29.8CD4, FOXP3, RELA, IL2RA, REL
19stomatitis29.8CSF2, CSF3
20pancytopenia29.8THPO, GBA, EPO, IL2RA, CSF3, CSF2
21neutropenia29.6CSF3, CSF2, EPO, THPO
22acute leukemia29.6CSF3, EPO, THPO, CSF2
23hodgkin's lymphoma29.5IL2RA, REL, PIK3R1, CSF2, CSF3
24liver cancer29.5F2, PIK3R1, TLR4, FOXP3, ALB, CD4
25thrombocytopenia29.2TLR4, CSF2, CD4, CSF3, ALB, EPO
26leukemia28.5IL7R, GBA, CSF3, CD4, PIK3R1, THPO
27hypertension10.7
28capillary leak syndrome10.6CSF2
29autoimmune thrombocytopenic purpura10.6THPO
30hydrops fetalis10.5GBA
31cryptosporidiosis10.5CD4
32sneddon syndrome10.5SERPINC1
33factor xii deficiency10.5SERPINC1
34cryptococcosis10.5CD4
35hepatocellular carcinoma10.5
36pyelonephritis10.4TLR4
37bernard-soulier syndrome10.4F2, THPO
38dysfibrinogenemia10.4F2, SERPINC1
39prothrombin deficiency10.4F2, SERPINC1
405q- syndrome10.4EPO
41megakaryocytic leukemia10.4CSF2, THPO
42antithrombin iii deficiency10.4SERPINC1, F2
43protein s deficiency10.4SERPINC1, F2
44hemorrhagic disease10.4SERPINC1, F2
45factor vii deficiency10.4F2, SERPINC1
46placental abruption10.4F2, SERPINC1
47tropical spastic paraparesis10.4IL2RA, FOXP3
48esophageal varix10.4ALB, F2
49histoplasmosis10.4RELA, REL
50autoimmune lymphoproliferative syndrome10.4IL2RA, CD4

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to hypersplenism

Symptoms for Hypersplenism

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Drugs & Therapeutics for Hypersplenism

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Drug clinical trials:

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Genetic Tests for Hypersplenism

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Anatomical Context for Hypersplenism

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MalaCards organs/tissues related to Hypersplenism:

32
Spleen, Liver, Bone marrow, Bone, T cells, Myeloid, Testes, B cells, Pineal, Brain, Pancreas, Breast

Animal Models for Hypersplenism or affiliated genes

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Publications for Hypersplenism

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Articles related to Hypersplenism:

(show top 50)    (show all 429)
idTitleAuthorsYear
1
A novel method for laparoscopic splenectomy in the setting of hypersplenism secondary to liver cirrhosis: ten years' experience. (24867471)
2014
2
Opportunistic Fonsecaea pedrosoi brain abscess in a patient with non-cirrhotic portal fibrosis-induced hypersplenism--a novel association. (23458558)
2013
3
Prophylaxis against hepatitis B virus recurrence after liver transplantation for hepatitis B virus-related end-stage liver diseases with severe hypersplenism and splenomegaly: role of splenectomy. (22483806)
2012
4
Partial splenic embolization using Bletilla striata particles for hypersplenism in cirrhosis: a prospective study. (21476204)
2011
5
Total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism. (21734807)
2011
6
Partial splenic embolization as an alternative to splenectomy in hypersplenism--single center experience in 16 years. (20862632)
2010
7
Hypersplenism caused by an accessory spleen mimicking an intra-abdominal neoplasm: report of a case. (19779782)
2009
8
Portal hypertension and hypersplenism in a patient with a Bochdalek hernia: a case report. (18398560)
2009
9
Two-year follow-up of splenic radiofrequency ablation in patients with cirrhotic hypersplenism: does increased hepatic arterial flow induce liver regeneration? (18374048)
2008
10
Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. (19039645)
2008
11
Congenital absence of the portal vein with splenomegaly and hypersplenism in a young woman. (12743449)
2003
12
Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. (12753144)
2003
13
Acute hypersplenism with splenomegaly after portal vein embolization. (12075192)
2002
14
Interleukin-11 administration normalizes the platelet count in a hypersplenic cirrhotic patient. (12424546)
2002
15
The first experience with non-operative treatment of hypersplenism in children with portal hypertension. (12469254)
2002
16
Partial splenic embolization for hypersplenism before and after liver transplantation. (12372046)
2002
17
Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome. (11170921)
2001
18
Hypersplenism. (11338057)
2001
19
Locoregional intrasplenic chemotherapy for hypersplenism in myelofibrosis. (11552991)
2001
20
Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. (11139352)
2000
21
Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis. (8946990)
1996
22
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism...". (8855767)
1996
23
Partial splenic embolisation and improvement of hypersplenism before liver transplantation. (7741576)
1995
24
Hypersplenism in liver cirrhosis: is conservative treatment still best? (8857456)
1995
25
Splenic ablation by percutaneous injection of ethanolamine oleate in dogs: a possible therapy for hypersplenism. (2606310)
1989
26
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
27
Hypersplenism secondary to a ruptured gallbladder and a pericholecystic abscess that presented as staphylococcal septicemia. (3949560)
1986
28
Computed tomography follow-up of nonsurgical treatment for hypersplenism. (3731807)
1986
29
Clinical disorders of splenic function: the spectrum from asplenism to hypersplenism. (6887967)
1983
30
Splenic embolization in a child with hypersplenism. (7161676)
1982
31
Partial splenic embolization in the management of hypersplenism secondary to Gaucher disease. (7131151)
1982
32
Isoniazid-related liver disease. Occurrence with portal hypertension, hypoalbuminemia, and hypersplenism. (448941)
1979
33
Splenectomy for hypersplenism. (707906)
1978
34
Control of hypersplenism and painful splenomegaly in myeloid metaplasia by irradiation. (413815)
1977
35
Hypersplenism in Hodgkin's disease: a report of three cases presenting with cytopenias. (593655)
1977
36
Experimental hypersplenism in mice. (131348)
1976
37
Partial splenectomy and pleural splenic transposition, a new approach to congestive hypersplenism of portal hypertension. (5037265)
1972
38
The kinetics of plaque-forming cells in experimental hypersplenism. (4999135)
1971
39
HYPERSPLENISM IN SICKLE CELL ANEMIA. (14170620)
1964
40
Hypersplenism. (13749081)
1961
41
Hypersplenism due to infection. A study of five cases manifesting hemolytic anemia. (13789380)
1961
42
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
43
Hypersplenism. (13230762)
1955
44
Secondary hypersplenism with recurrent gastrointestinal bleeding. (13059633)
1953
45
Surgical aspects of hypersplenism. (13036936)
1953
46
Pancreatic cyst; an unusual cause of hypersplenism. (12996227)
1952
47
Hypersplenism. (14863408)
1951
48
The use of ACTH in hypersplenism. (14931201)
1951
49
Hypersplenism in a patient with lymphogranuloma benignum. (15391143)
1949
50
The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. (21013546)
1946

Variations for Hypersplenism

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Expression for genes affiliated with Hypersplenism

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Expression patterns in normal tissues for genes affiliated with Hypersplenism

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Pathways for genes affiliated with Hypersplenism

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Pathways related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.6FOXP3, IL2RA, CSF2
2
Show member pathways
9.6FOXP3, IL2RA, CSF2
3
Show member pathways
9.5IL2RA, PIK3R1, CD4
4
Show member pathways
9.4IL2RA, F2, PIK3R1, THPO
59.4CSF2, CD4, CSF3
69.1RELA, IL2RA, IL7R
7
Show member pathways
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.1PIK3R1, REL, RELA
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades59
9.1RELA, PIK3R1, REL
9
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling59
Leptin signaling pathway37
9.1RELA, PIK3R1, REL
109.1REL, PIK3R1, RELA
119.1REL, RELA, PIK3R1
12
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.1REL, RELA, PIK3R1
13
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.1REL, RELA, PIK3R1
14
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.0TLR4, REL, RELA
159.0RELA, TLR4, REL
169.0PIK3R1, CSF2, RELA
17
Show member pathways
9.0RELA, IL2RA, PIK3R1
18
Show member pathways
8.9TLR4, CSF2, RELA
19
Show member pathways
thioredoxin pathway37
8.9F2, RELA, ALB
20
Show member pathways
8.9PIK3R1, TLR4, RELA
21
Show member pathways
Immune response IL 12 induced IFN gamma production59
8.8CD4, RELA, REL, IL2RA
22
Show member pathways
8.8SERPINC1, THPO, PIK3R1, F2, ALB
23
Show member pathways
Immune response T cell receptor signaling pathway59
Immune response CD28 signaling59
Immune response ICOS pathway in T helper cell59
8.8CD4, RELA, REL, PIK3R1
24
Show member pathways
8.8CD4, REL, RELA, PIK3R1
25
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells37
8.8PIK3R1, RELA, REL, CSF2
26
Show member pathways
Immune response IL 3 activation and signaling pathway59
8.8IL2RA, REL, PIK3R1, RELA
27
Show member pathways
IL2 signaling events mediated by STAT537
8.7IL2RA, FOXP3, RELA, PIK3R1
288.7PIK3R1, CSF2, IL2RA, RELA
29
Show member pathways
8.7TLR4, RELA, PIK3R1, FOXP3
308.6CSF2, TLR4, PIK3R1, RELA
31
Show member pathways
8.6TLR4, PIK3R1, IL2RA, RELA
32
Show member pathways
8.6PIK3R1, TLR4, IL2RA, RELA
33
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.6REL, F2, PIK3R1, CD4, RELA
34
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
8.5THPO, PIK3R1, RELA, IL7R, IL2RA
35
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.5CD4, CSF2, RELA, PIK3R1, REL
36
Show member pathways
8.5TLR4, REL, PIK3R1, THPO, RELA
378.4RELA, TLR4, PIK3R1, EPO
38
Show member pathways
8.4PIK3R1, IL2RA, IL7R, CSF2, RELA
39
Show member pathways
8.4RELA, PIK3R1, CSF2, IL7R, IL2RA
40
Show member pathways
8.4CD4, PIK3R1, EVL, RELA
41
Show member pathways
8.4F2, EPO, IL7R, CD4, IL2RA, THPO
42
Show member pathways
Type III interferon signaling37
8.3EPO, IL2RA, IL7R, CSF2, CSF3, PIK3R1
43
Show member pathways
8.2CD4, THPO, PIK3R1, CSF3, IL2RA, IL7R
44
Show member pathways
8.2IL2RA, IL7R, CD4, CSF3, CSF2, PIK3R1
45
Show member pathways
8.2EVL, RELA, REL, PIK3R1, CD4
468.1CD4, IL2RA, THPO, EPO, CSF2, IL7R
47
Show member pathways
7.9CSF3, RELA, TLR4, REL, FOXP3, CSF2
48
Show member pathways
7.8PIK3R1, THPO, TLR4, IL2RA, CSF3, CSF2
497.3CSF3, IL7R, PIK3R1, TLR4, EPO, RELA
50
Show member pathways
6.5CSF3, TLR4, F2, EPO, RELA, IL2RA

Compounds for genes affiliated with Hypersplenism

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Compounds related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1anagrelide44 1210.9THPO, CSF2, EPO
2mafosfamide449.8CSF3, THPO, CSF2
3hepaplastin449.7SERPINC1, ALB, F2
4tranexamic acid44 1210.7F2, EPO, SERPINC1
5phenprocoumon44 50 1211.7F2, SERPINC1, ALB
6pegfilgrastim44 1210.6CSF2, CSF3, EPO
7epsilon aminocaproic acid449.4SERPINC1, F2, EPO
8pixy321449.4CSF3, EPO, THPO, CSF2
9amifostine44 1210.4CSF3, EPO, THPO, CSF2
10filgrastim44 1210.4THPO, CSF2, CSF3, EPO
11gm-csf44 2910.4THPO, EPO, CSF2, CSF3
12anti-fungal449.4CSF3, CSF2, TLR4, REL
13methylcellulose449.4CSF3, CSF2, THPO, EPO
14polyethylene glycol449.4SERPINC1, F2, THPO, ALB
15chloroquine44 3 50 29 1213.3SERPINC1, TLR4, CD4, IL2RA
16hydroxyethyl starch449.3SERPINC1, CSF3, F2, ALB
17carboplatin44 50 1211.2EPO, CSF3, CSF2, THPO
18hydroxyurea44 50 1211.2CSF3, F2, CSF2, THPO, EPO
19bleomycin44 1210.2CSF2, EPO, IL2RA, CSF3
20etoposide44 50 60 1212.0PIK3R1, IL2RA, CSF2, CSF3, THPO
21mycophenolate mofetil44 50 1211.0ALB, CSF3, EPO, IL2RA
22aminoguanidine44 29 1211.0TLR4, EPO, ALB
23genistein44 29 60 3 25 1214.0PIK3R1, IL2RA, TLR4, CSF2, THPO, CD4
24pge2448.9CSF2, FOXP3, TLR4, SERPINC1, IL2RA, CD4
25fibrinogen448.9ALB, SERPINC1, TLR4, THPO, F2
26aspirin44 50 29 2511.8GBA, F2, THPO, TLR4, SERPINC1, IL2RA
27zidovudine44 50 1210.8CD4, ALB, CSF2, EPO, CSF3
28imatinib44 50 1210.8THPO, PIK3R1, EPO, CSF3, ALB
29polysaccharide448.7TLR4, THPO, SERPINC1, CSF2, GBA, IL2RA
30estrogen448.7CSF2, PIK3R1, IL2RA, F2, THPO, SERPINC1
31histamine44 29 2510.7THPO, TLR4, IL2RA, ALB, CSF2
32lactate448.7ALB, EPO, F2, TLR4, THPO, CSF2
33creatinine448.7F2, IL2RA, SERPINC1, EPO, ALB, THPO
34calcitriol44 60 25 1211.7CSF2, IL2RA, EPO, TLR4, F2, ALB
35rantes448.6CD4, CSF3, CSF2, REL, THPO, IL2RA
36vitamin d448.6ALB, TLR4, EPO, CSF2, IL2RA
37phospholipid448.6PIK3R1, IL2RA, TLR4, GBA, F2
38gp 130448.5CSF3, CSF2, IL7R, PIK3R1, THPO, EPO
39aspartate448.5EPO, ALB, IL2RA, TLR4, PIK3R1, F2
40thymidine44 259.5PIK3R1, GBA, IL2RA, CSF2, EPO, CSF3
41heparin44 29 25 1211.4THPO, CSF2, IL7R, IL2RA, SERPINC1, F2
42cysteine448.3CSF2, ALB, CD4, IL2RA, REL, TLR4
43phosphatidylinositol448.3CD4, CSF2, IL7R, IL2RA, EPO, THPO
44cyclosporin a44 29 6010.2F2, REL, FOXP3, IL2RA, CSF2, CSF3
45methotrexate50 44 1210.2F2, TLR4, EPO, IL2RA, ALB, CSF3
46dexamethasone44 50 29 1211.2CSF2, REL, CSF3, SERPINC1, IL2RA, TLR4
47vegf448.0THPO, PIK3R1, CSF3, TLR4, SERPINC1, EPO
48testosterone44 60 25 1210.7EPO, IL2RA, ALB, PIK3R1, SERPINC1, RELA
49serine447.7PIK3R1, RELA, F2, GBA, CD4, REL
50tyrosine447.6EPO, REL, IL2RA, IL7R, CSF2, CD4

GO Terms for genes affiliated with Hypersplenism

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Cellular components related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4ALB, SERPINC1, F2
2external side of plasma membraneGO:0098979.1TLR4, IL2RA, IL7R, CD4
3extracellular regionGO:0055768.0F2, SERPINC1, EPO, IL7R, CSF2, ALB
4extracellular spaceGO:0056157.9ALB, CSF3, CSF2, EPO, SERPINC1, THPO

Biological processes related to Hypersplenism according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immune responseGO:05077710.1FOXP3, IL2RA
2cytokine productionGO:00181610.0REL, FOXP3, CD4
3macrophage activationGO:04211610.0TLR4, CSF2
4negative regulation of neuron deathGO:19012159.9CSF3, REL
5negative regulation of interleukin-6 productionGO:0327159.9FOXP3, TLR4, GBA
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9CSF2, EPO
7negative regulation of osteoclast differentiationGO:0456719.8TLR4, PIK3R1
8negative regulation of interferon-gamma productionGO:0326899.8FOXP3, TLR4
9negative regulation of inflammatory responseGO:0507289.8IL2RA, SERPINC1, GBA
10response to testosteroneGO:0335749.7EPO, GBA
11defense response to Gram-negative bacteriumGO:0508299.5CD4, TLR4
12platelet activationGO:0301689.4F2, PIK3R1, THPO, ALB
13positive regulation of interleukin-12 biosynthetic processGO:0450849.4TLR4, RELA, REL
14cell surface receptor signaling pathwayGO:0071669.1CD4, EVL, IL7R, IL2RA, F2
15T cell receptor signaling pathwayGO:0508529.1PIK3R1, RELA, FOXP3, CD4
16blood coagulationGO:0075969.1F2, PIK3R1, THPO, SERPINC1, ALB
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1TLR4, RELA, REL
18cellular response to lipopolysaccharideGO:0712228.7TLR4, RELA, CSF2, CSF3
19immune responseGO:0069558.7CD4, CSF3, CSF2, IL7R, IL2RA, TLR4
20positive regulation of transcription, DNA-templatedGO:0458938.7EPO, RELA, REL, FOXP3
21positive regulation of cell proliferationGO:0082848.4CSF3, CSF2, RELA, EPO, F2
22positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CSF3, FOXP3, RELA, TLR4, PIK3R1

Molecular functions related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NF-kappaB bindingGO:0510599.4FOXP3, RELA
2cytokine activityGO:0051259.1CSF3, CSF2, THPO
3growth factor activityGO:0080839.1F2, THPO, CSF2, CSF3
4protein bindingGO:0055155.1CD4, GBA, F2, PIK3R1, TLR4, SERPINC1

Products for genes affiliated with Hypersplenism

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Sources for Hypersplenism

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29IUPHAR
30KEGG
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