MCID: HYP063
MIFTS: 49

Hypersplenism

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Hypersplenism

MalaCards integrated aliases for Hypersplenism:

Name: Hypersplenism 12 51 41 14 69
Hypersplenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6376
ICD10 32 D73.1
ICD9CM 34 289.4
MeSH 41 D006971
NCIt 46 C34714
UMLS 69 C0020532

Summaries for Hypersplenism

MalaCards based summary : Hypersplenism, also known as hypersplenia, is related to portal hypertension and liver cirrhosis. An important gene associated with Hypersplenism is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Heparin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

Related Diseases for Hypersplenism

Diseases related to Hypersplenism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 portal hypertension 30.7 ALB F2 THPO
2 liver cirrhosis 30.0 ALB F2 SERPINC1 THPO
3 portal vein thrombosis 29.9 F2 SERPINC1
4 esophageal varix 29.8 ALB F2 SERPINC1
5 hepatitis b 29.8 ALB F2 IFNG
6 schistosomiasis 29.7 ALB F2 IFNG
7 endocarditis 29.6 ALB F2 SERPINC1
8 peripheral vascular disease 29.6 ALB F2 SERPINC1
9 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.6 FOXP3 IFNG
10 purpura 29.6 F2 SERPINC1 THPO
11 acquired immunodeficiency syndrome 29.2 ALB EPO IFNG IL2RA
12 malaria 29.1 ALB EPO FOXP3 IFNG
13 splenomegaly 11.3
14 nodular regenerative hyperplasia 10.9
15 antipyrine metabolism 10.5 ALB F2
16 non-a-e hepatitis 10.5 ALB F2
17 abdominal tuberculosis 10.5 ALB F2
18 kwashiorkor 10.5 ALB F2
19 hepatic tuberculosis 10.5 ALB F2
20 hepatic coma 10.5 ALB F2
21 ascending cholangitis 10.4 ALB F2
22 tuberculous peritonitis 10.4 ALB IFNG
23 fetal erythroblastosis 10.4 ALB EPO
24 compartment syndrome 10.4 ALB F2
25 chronic inflammatory demyelinating polyradiculoneuropathy 10.4 ALB IFNG
26 fascioliasis 10.4 ALB IFNG
27 spinal cord infarction 10.4 F2 SERPINC1
28 intestinal impaction 10.4 F2 SERPINC1
29 burns 10.4 ALB SERPINC1
30 sudden sensorineural hearing loss 10.4 F2 SERPINC1
31 acute necrotizing encephalitis 10.4 FOXP3 IFNG
32 blood protein disease 10.4 F2 SERPINC1
33 hepatorenal syndrome 10.4 ALB F2
34 leech infestation 10.4 F2 SERPINC1
35 alpha-2-plasmin inhibitor deficiency 10.4 F2 SERPINC1
36 giant hemangioma 10.4 F2 SERPINC1
37 prothrombin deficiency, congenital 10.4 F2 SERPINC1
38 sagittal sinus thrombosis 10.4 F2 SERPINC1
39 blue toe syndrome 10.4 F2 SERPINC1
40 intracranial embolism 10.4 F2 SERPINC1
41 ischemic colitis 10.3 F2 SERPINC1
42 choledocholithiasis 10.3 ALB F2
43 rh isoimmunization 10.3 ALB EPO
44 anterior spinal artery syndrome 10.3 F2 SERPINC1
45 subendocardial myocardial infarction 10.3 F2 SERPINC1
46 sneddon syndrome 10.3 F2 SERPINC1
47 marantic endocarditis 10.3 F2 SERPINC1
48 retinal artery occlusion 10.3 F2 SERPINC1
49 purpura fulminans 10.3 F2 SERPINC1
50 korean hemorrhagic fever 10.3 F2 SERPINC1

Comorbidity relations with Hypersplenism via Phenotypic Disease Network (PDN): (show all 12)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Alcoholic Liver Cirrhosis
Chronic Congestive Splenomegaly Deficiency Anemia
Heart Disease Hepatic Encephalopathy
Iron Deficiency Anemia Neutropenia
Portal Hypertension Primary Thrombocytopenia

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to Hypersplenism

Symptoms & Phenotypes for Hypersplenism

MGI Mouse Phenotypes related to Hypersplenism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 EPO PIK3R1 F2 SERPINC1 FOXP3 THPO
2 homeostasis/metabolism MP:0005376 9.97 EPO PIK3R1 F2 SERPINC1 FOXP3 THPO
3 immune system MP:0005387 9.91 EPO PIK3R1 F2 SERPINC1 FOXP3 THPO
4 liver/biliary system MP:0005370 9.63 EPO PIK3R1 SERPINC1 FOXP3 IFNG ALB
5 mortality/aging MP:0010768 9.56 EPO PIK3R1 F2 SERPINC1 FOXP3 IFNG
6 normal MP:0002873 9.17 IL7R EPO PIK3R1 F2 FOXP3 IFNG

Drugs & Therapeutics for Hypersplenism

Drugs for Hypersplenism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Dipyridamole Approved Phase 4 58-32-2 3108
4
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
5
Warfarin Approved Phase 4 81-81-2 54678486 6691
6 Nadroparin Approved, Investigational Phase 4 9041-08-1
7
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
8
Dalteparin Approved Phase 4 9005-49-6
9 tannic acid Approved, Nutraceutical Phase 4
10 Liver Extracts Phase 4,Phase 2,Phase 3
11 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
12 calcium heparin Phase 4
13 Analgesics Phase 4
14 Fibrinolytic Agents Phase 4
15 Adrenergic Agents Phase 4
16 Adrenergic alpha-1 Receptor Antagonists Phase 4
17 Adrenergic alpha-Antagonists Phase 4
18 Adrenergic Antagonists Phase 4
19 Adrenergic beta-Antagonists Phase 4
20 Cyclooxygenase Inhibitors Phase 4
21 Heparin, Low-Molecular-Weight Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Vasodilator Agents Phase 4
24 Peripheral Nervous System Agents Phase 4
25 Anticoagulants Phase 4
26 Phosphodiesterase Inhibitors Phase 4
27 Platelet Aggregation Inhibitors Phase 4
28 Antihypertensive Agents Phase 4
29 Anti-Inflammatory Agents Phase 4
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4
31 Antipyretics Phase 4
32 Antirheumatic Agents Phase 4
33 Calcium, Dietary Phase 4
34
Valproic Acid Approved, Investigational Phase 1, Phase 2 99-66-1 3121
35
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
36
Tegafur Approved, Investigational Phase 2 17902-23-7 5386
37
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
38
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
39
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
40 Central Nervous System Depressants Phase 1, Phase 2
41 GABA Agents Phase 1, Phase 2
42 Tranquilizing Agents Phase 1, Phase 2
43 Anticonvulsants Phase 1, Phase 2
44 Antimanic Agents Phase 1, Phase 2
45 Psychotropic Drugs Phase 1, Phase 2
46 Micronutrients Phase 2
47 Trace Elements Phase 2
48 Nicotinic Acids Phase 2
49 Vitamin B Complex Phase 2
50 Vitamins Phase 2

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy Recruiting NCT02238444 Phase 4 Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
2 Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS Recruiting NCT02925975 Phase 4 Carvedilol
3 ABMSC Infusion Through Hepatic Artery in Portal Hypertension Surgery for the Treatment of Liver Cirrhosis Unknown status NCT01560845 Phase 2, Phase 3
4 Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Completed NCT00605657 Phase 1, Phase 2 Valproic Acid
5 Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACE Terminated NCT01539018 Phase 2 Sorafenib;sorafenib plus tegafur-uracil
6 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584
7 Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis Unknown status NCT01201655
8 Treatment of Portal Vein Tumor Thrombus After Hepatocellular Carcinoma Resection Completed NCT00825669 TACE
9 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
10 The Treatment of Hepatocirrhosis and Portal Hypertension Recruiting NCT02778425
11 The Natural History and Prognostic Factors of Compensated Cirrhosis. Recruiting NCT03144700
12 Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension Not yet recruiting NCT03269877

Search NIH Clinical Center for Hypersplenism

Cochrane evidence based reviews: hypersplenism

Genetic Tests for Hypersplenism

Anatomical Context for Hypersplenism

MalaCards organs/tissues related to Hypersplenism:

38
Spleen, Liver, Bone, Bone Marrow, T Cells, Myeloid, Testes

Publications for Hypersplenism

Articles related to Hypersplenism:

(show top 50) (show all 491)
# Title Authors Year
1
Epithelial cyst of spleen presenting as hypersplenism. ( 29386740 )
2018
2
Hypersplenism secondary to splenoportal axis compression by a giant hepatic cyst. ( 29019252 )
2018
3
Laparoscopic splenectomy and subsequent oncologic gastric surgery in cirrhotic patients with portal hypertension and hypersplenism. ( 29391322 )
2018
4
Incidence and risk factors associated with a high comprehensive complication index score after splenectomy in cirrhotic patients with hypersplenism. ( 29273377 )
2018
5
Airway management of a paediatric patient with temporomandibular joint ankylosis with extra hepatic portal vein obstruction, splenomegaly, hypersplenism, and obstructive sleep apnoea for shunt surgery: A unique challenge. ( 29217866 )
2017
6
Microwave ablation in the spleen versus partial splenic artery embolisation: A new technique for hypersplenism in cirrhosis. ( 28256406 )
2017
7
Postoperative Prognostic Nutritional Index Predicts Survival of Patients with Hepatocellular Carcinoma within Milan Criteria and Hypersplenism. ( 28523484 )
2017
8
Partial Splenic Artery Embolization to Treat Hypersplenism Secondary to Hepatic Cirrhosis: A Meta-Analysis. ( 28316312 )
2017
9
JOURNAL CLUB: Four-Dimensional Flow MRI-Based Splenic Flow Index for Predicting Cirrhosis-Associated Hypersplenism. ( 28463524 )
2017
10
Klippel-Trenaunay-Weber syndrome with atypical presentation of hypersplenism and nephrotic syndrome: a case report. ( 28823249 )
2017
11
Successful Treatment of Hypersplenism in Wilson's Disease by Partial Splenic Embolization. ( 28135891 )
2017
12
Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension. ( 27006743 )
2016
13
Hypersplenism Associated With Late-Presenting Congenital Diaphragmatic Hernia: A Rare Combination. Case Report. ( 27227931 )
2016
14
A Comparative Study of Surgical Splenectomy, Partial Splenic Embolization, and High-Intensity Focused Ultrasound for Hypersplenism. ( 26839374 )
2016
15
Hepatocellular Carcinoma with Hypersplenic Thrombocytopenia and Situs Inversus Totalis: A Case Report. ( 28031104 )
2016
16
Laparoscopic Splenectomy for the Elderly Liver Cirrhotic Patients With Hypersplenism: A Retrospective Comparable Study. ( 26962816 )
2016
17
Dameshek W, Miller EB. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. 1946. ( 26744432 )
2016
18
Pancreatic fistula after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis: effect of fibrin glue and polyglycolic acid felt on prophylaxis of postoperative complications. ( 27162072 )
2016
19
Risk Factors for Portal Vein System Thrombosis After Laparoscopic Splenectomy in Cirrhotic Patients with Hypersplenism. ( 26953863 )
2016
20
Laparoscopic versus traditional open splenectomy for hepatocellular carcinoma with hypersplenism. ( 27465326 )
2016
21
Laparoscopic splenic artery ligation for hypersplenism in cirrhosis: A case series. ( 27251809 )
2016
22
Simultaneous microwave coagulo-necrotic therapy (MCN) and laparoscopic splenectomy for the treatment of hepatocellular carcinoma with cirrhotic hypersplenism. ( 27577937 )
2016
23
Hypersplenism: History and current status. ( 27703501 )
2016
24
Severe hypersplenism associated to hemophagocytic and lymphoproliferative syndrome secondary to Epstein-Barr virus infection. A report of two cases. ( 27041246 )
2016
25
Hypersplenism is correlated with increased risk of hepatocellular carcinoma in patients with post-hepatitis cirrhosis. ( 26753954 )
2016
26
Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process. ( 26865982 )
2016
27
Partial Splenic Embolization in a Child with Sickle Cell Disease and Hypersplenism. ( 27926404 )
2016
28
Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism. ( 27393102 )
2016
29
Treatment of Hypersplenism by Partial Splenic Embolization Through Gastric Collaterals. ( 27200164 )
2016
30
Influence of lactulose on interventional therapy for HCC patients with hepatocirrhosis and hypersplenism. ( 26919955 )
2016
31
Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study. ( 25741142 )
2015
32
Comparison of two laparoscopic splenectomy plus pericardial devascularization techniques for management of portal hypertension and hypersplenism. ( 25783835 )
2015
33
Successful Splenectomy for Hypersplenism in Wilson's Disease: A Single Center Experience from China. ( 25910248 )
2015
34
Partial splenic embolization of patients with hypersplenism by transradial or transfemoral approach: a prospective randomized controlled trial. ( 26671306 )
2015
35
Can hypersplenism secondary to portal hypertension be treated by non-selective beta blockers? ( 25788189 )
2015
36
Percutaneous Microwave Ablation in the Spleen for Treatment of Hypersplenism in Cirrhosis Patients. ( 26031423 )
2015
37
Thrombocytopenia due to hypersplenism in oncological disease: Partial splenic embolization during palliative treatment. ( 25737395 )
2015
38
Partial Splenic Artery Embolization for the Management of Hypersplenism in Cirrhosis. ( 26388645 )
2015
39
Splenectomy Followed by Hepatectomy for Hepatocellular Carcinoma with Hypersplenism and Portal Hypertension Caused by Macroglobulinemia. ( 26124358 )
2015
40
Portal and splanchnic hemodynamics after partialA splenic embolization in cirrhotic patients with hypersplenism. ( 26547369 )
2015
41
Hypersplenism Treated by Partial Splenic Embolization Using Guglielmi Detachable Coils. ( 26328643 )
2015
42
Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option. ( 26034376 )
2015
43
Isolated Splenic Vein Thrombosis: 8-Year-Old Boy with Massive Upper Gastrointestinal Bleeding and Hypersplenism. ( 26345989 )
2015
44
Microwave Ablation for the Treatment of Hypersplenism: Short Waves, Low Cost, Big Results. ( 26541991 )
2015
45
Laparoscopic splenic vessels ligation as a treatment of hypersplenism and thrombocytopenia in children. ( 26659241 )
2015
46
Utility of Partial Splenic Embolization for Hypersplenism using Guglielmi Detachable Coils. ( 26897954 )
2015
47
Laparoscopic surgery is more advantageous than laparotomic surgery for treatment of hypersplenism with gallstones. ( 26091138 )
2015
48
Simultaneous hepatectomy and splenectomy versus hepatectomy alone for hepatocellular carcinoma complicated by hypersplenism: a meta-analysis. ( 26316782 )
2015
49
Anaesthetic management of beta thalassemia major with hypersplenism for splenectomy in pediatric age group: Report of four cases. ( 26417142 )
2015
50
Hypersplenism: an independent risk factor for myocardial remodeling in chronic heart failure patients. ( 26131093 )
2015

Variations for Hypersplenism

Expression for Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

Pathways for Hypersplenism

Pathways related to Hypersplenism according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 EPO F2 IFNG IL2RA IL7R PIK3R1
2
Show member pathways
13.24 EPO F2 IFNG IL2RA IL7R PIK3R1
3
Show member pathways
13.07 ALB F2 IL2RA PIK3R1 SERPINC1 THPO
4
Show member pathways
12.75 EPO IL2RA IL7R PIK3R1
5 12.55 EPO IFNG IL2RA IL7R PIK3R1
6
Show member pathways
12.54 IL2RA IL7R PIK3R1 THPO
7
Show member pathways
12.12 ALB F2 IFNG
8
Show member pathways
11.86 IFNG IL2RA PIK3R1
9 11.72 EPO IFNG PIK3R1
10 11.62 IFNG IL2RA IL7R
11
Show member pathways
11.58 FOXP3 IFNG IL2RA
12 11.54 EPO IL2RA IL7R THPO
13
Show member pathways
11.48 FOXP3 IL2RA PIK3R1
14
Show member pathways
11.48 EPO IFNG IL2RA IL7R PIK3R1 THPO
15 11.46 EPO IFNG IL2RA IL7R PIK3R1
16 11.42 EPO IFNG IL2RA IL7R THPO
17 11.24 FOXP3 IFNG IL2RA
18
Show member pathways
11.19 IL2RA IL7R PIK3R1
19 11.14 IFNG IL2RA
20 11.05 IFNG IL2RA
21 11.05 IL7R PIK3R1
22
Show member pathways
11.05 FOXP3 IFNG IL2RA
23 10.99 F2 IFNG
24 10.98 IFNG IL2RA
25 10.92 IFNG PIK3R1

GO Terms for Hypersplenism

Cellular components related to Hypersplenism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ALB EPO F2 IFNG SERPINC1 THPO
2 blood microparticle GO:0072562 9.33 ALB F2 SERPINC1
3 extracellular region GO:0005576 9.17 ALB EPO F2 IFNG IL7R SERPINC1

Biological processes related to Hypersplenism according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.76 EPO F2 IFNG IL7R
2 cellular protein metabolic process GO:0044267 9.69 ALB F2 SERPINC1
3 regulation of receptor activity GO:0010469 9.67 EPO F2 IFNG THPO
4 positive regulation of protein phosphorylation GO:0001934 9.58 F2 IFNG THPO
5 negative regulation of T cell proliferation GO:0042130 9.54 FOXP3 IL2RA
6 acute-phase response GO:0006953 9.52 EPO F2
7 T cell homeostasis GO:0043029 9.49 FOXP3 IL2RA
8 positive regulation of activated T cell proliferation GO:0042104 9.48 EPO IL2RA
9 cell surface receptor signaling pathway GO:0007166 9.46 F2 IFNG IL2RA IL7R
10 regulation of blood coagulation GO:0030193 9.43 F2 SERPINC1
11 negative regulation of immune response GO:0050777 9.32 FOXP3 IL2RA
12 negative regulation of interleukin-17 production GO:0032700 9.26 FOXP3 IFNG
13 negative regulation of lymphocyte proliferation GO:0050672 8.96 FOXP3 IL2RA
14 regulation of regulatory T cell differentiation GO:0045589 8.8 FOXP3 IFNG IL2RA

Molecular functions related to Hypersplenism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 EPO IFNG THPO

Sources for Hypersplenism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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