MCID: HYP063
MIFTS: 58

Hypersplenism malady

Immune diseases, Blood diseases categories
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Summaries for Hypersplenism

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65Wikipedia, 33MalaCards
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Wikipedia:65 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards: Hypersplenism, also known as hypersplenia, is related to portal hypertension and splenomegaly. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds anagrelide and mafosfamide have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone marrow, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Hypersplenism

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 40NCIt, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

hypersplenism 8 10 45 62
hypersplenia 8


External Ids:

Disease Ontology8 DOID:6376
MeSH35 D006971
NCIt40 C34714
ICD9CM27 289.4
ICD1025 D73.1

Related Diseases for Hypersplenism

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17GeneCards, 18GeneDecks
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Diseases related to Hypersplenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension31.1EVL
2splenomegaly30.9GBA, THPO, EPO, IL2RA, CSF3
3hepatitis30.8ALB, THPO, F2
4liver cirrhosis30.7F2, THPO, SERPINC1, ALB
5hepatitis c30.6TLR4, THPO, F2
6hepatocellular carcinoma30.6F2, PIK3R1, TLR4, FOXP3, ALB, CD4
7thrombocytopenia30.4CD4, ALB, CSF3, CSF2, EPO, SERPINC1
8pancytopenia30.2GBA, THPO, EPO, IL2RA, CSF2, CSF3
9tuberculosis30.2TLR4, IL2RA, ALB, CD4
10portal vein thrombosis30.2SERPINC1, THPO, F2
11myelofibrosis30.2THPO, EPO
12acquired immunodeficiency syndrome30.1CSF2, ALB, CD4
13felty's syndrome30.1CSF2, CSF3
14hepatitis b30.1F2, TLR4, ALB, CD4
15arthritis30.0CD4, ALB, CSF2, FOXP3, TLR4
16arteriovenous fistula30.0EPO
17purpura30.0THPO, SERPINC1
18malaria29.9ALB, CD4
19vascular disease29.9CD4, SERPINC1
20polycythemia29.9THPO, EPO
21leukemia29.8GBA, PIK3R1, THPO, TLR4, EPO, REL
22t-cell leukemia29.8RELA, REL, FOXP3, IL2RA, CD4
23stomatitis29.8CSF3, CSF2
24myeloproliferative disorder29.8THPO, EPO, CSF2, CSF3
25neutropenia29.8THPO, EPO, CSF2, CSF3
26acute leukemia29.8CSF3, CSF2, EPO, THPO
27hodgkin's lymphoma29.8PIK3R1, REL, IL2RA, CSF2, CSF3
28hypertension10.6
29liver disease10.3
30hepatitis c virus10.2
31sickle cell anemia10.2
32sickle cell disease10.2
33capillary leak syndrome10.1CSF2
34gaucher's disease10.1
35lymphosarcoma10.1
36pancreatitis10.1
37aneurysm10.1
38autoimmune thrombocytopenic purpura10.1THPO
39hydrops fetalis10.1GBA
40purpura fulminans10.1SERPINC1
41cryptosporidiosis10.1CD4
42sneddon syndrome10.1SERPINC1
43factor xii deficiency10.1SERPINC1
44cryptococcosis10.1CD4
45pyelonephritis10.1TLR4
46bernard-soulier syndrome10.1F2, THPO
47dysfibrinogenemia10.1SERPINC1, F2
48prothrombin deficiency10.1F2, SERPINC1
495q- syndrome10.1EPO
50megakaryocytic leukemia10.1THPO, CSF2

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to hypersplenism

Symptoms for Hypersplenism

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Drugs & Therapeutics for Hypersplenism

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Hypersplenism

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Anatomical Context for Hypersplenism

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33MalaCards
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MalaCards organs/tissues related to Hypersplenism:

33
Spleen, Liver, Bone marrow, Bone, T cells, Myeloid, B cells, Testes, Pineal, Pancreas, Brain, Breast

Animal Models for Hypersplenism or affiliated genes

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37MGI
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Publications for Hypersplenism

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52PubMed
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Articles related to Hypersplenism:

(show top 50)    (show all 421)
idTitleAuthorsYear
1
Opportunistic Fonsecaea pedrosoi brain abscess in a patient with non-cirrhotic portal fibrosis-induced hypersplenism--a novel association. (23458558)
2013
2
Prophylaxis against hepatitis B virus recurrence after liver transplantation for hepatitis B virus-related end-stage liver diseases with severe hypersplenism and splenomegaly: role of splenectomy. (22483806)
2012
3
Partial splenic embolization using Bletilla striata particles for hypersplenism in cirrhosis: a prospective study. (21476204)
2011
4
Total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism. (21734807)
2011
5
Partial splenic embolization as an alternative to splenectomy in hypersplenism--single center experience in 16 years. (20862632)
2010
6
Hypersplenism caused by an accessory spleen mimicking an intra-abdominal neoplasm: report of a case. (19779782)
2009
7
Portal hypertension and hypersplenism in a patient with a Bochdalek hernia: a case report. (18398560)
2009
8
Two-year follow-up of splenic radiofrequency ablation in patients with cirrhotic hypersplenism: does increased hepatic arterial flow induce liver regeneration? (18374048)
2008
9
Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. (19039645)
2008
10
Congenital absence of the portal vein with splenomegaly and hypersplenism in a young woman. (12743449)
2003
11
Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. (12753144)
2003
12
Acute hypersplenism with splenomegaly after portal vein embolization. (12075192)
2002
13
Interleukin-11 administration normalizes the platelet count in a hypersplenic cirrhotic patient. (12424546)
2002
14
The first experience with non-operative treatment of hypersplenism in children with portal hypertension. (12469254)
2002
15
Partial splenic embolization for hypersplenism before and after liver transplantation. (12372046)
2002
16
Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome. (11170921)
2001
17
Hypersplenism. (11338057)
2001
18
Locoregional intrasplenic chemotherapy for hypersplenism in myelofibrosis. (11552991)
2001
19
Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. (11139352)
2000
20
Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis. (8946990)
1996
21
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism...". (8855767)
1996
22
A long-term investigation of transcatheter splenic arterial embolization for hypersplenism. (8682485)
1996
23
Partial splenic embolisation and improvement of hypersplenism before liver transplantation. (7741576)
1995
24
Hypersplenism in liver cirrhosis: is conservative treatment still best? (8857456)
1995
25
Splenic ablation by percutaneous injection of ethanolamine oleate in dogs: a possible therapy for hypersplenism. (2606310)
1989
26
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
27
Hypersplenism secondary to a ruptured gallbladder and a pericholecystic abscess that presented as staphylococcal septicemia. (3949560)
1986
28
Computed tomography follow-up of nonsurgical treatment for hypersplenism. (3731807)
1986
29
Clinical disorders of splenic function: the spectrum from asplenism to hypersplenism. (6887967)
1983
30
Splenic embolization in a child with hypersplenism. (7161676)
1982
31
Partial splenic embolization in the management of hypersplenism secondary to Gaucher disease. (7131151)
1982
32
Isoniazid-related liver disease. Occurrence with portal hypertension, hypoalbuminemia, and hypersplenism. (448941)
1979
33
Splenectomy for hypersplenism. (707906)
1978
34
Control of hypersplenism and painful splenomegaly in myeloid metaplasia by irradiation. (413815)
1977
35
Hypersplenism in Hodgkin's disease: a report of three cases presenting with cytopenias. (593655)
1977
36
Experimental hypersplenism in mice. (131348)
1976
37
Partial splenectomy and pleural splenic transposition, a new approach to congestive hypersplenism of portal hypertension. (5037265)
1972
38
The kinetics of plaque-forming cells in experimental hypersplenism. (4999135)
1971
39
HYPERSPLENISM IN SICKLE CELL ANEMIA. (14170620)
1964
40
Hypersplenism. (13749081)
1961
41
Hypersplenism due to infection. A study of five cases manifesting hemolytic anemia. (13789380)
1961
42
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
43
Hypersplenism. (13230762)
1955
44
Secondary hypersplenism with recurrent gastrointestinal bleeding. (13059633)
1953
45
Surgical aspects of hypersplenism. (13036936)
1953
46
Pancreatic cyst; an unusual cause of hypersplenism. (12996227)
1952
47
Hypersplenism. (14863408)
1951
48
The use of ACTH in hypersplenism. (14931201)
1951
49
Hypersplenism in a patient with lymphogranuloma benignum. (15391143)
1949
50
The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. (21013546)
1946

Variations for Hypersplenism

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Expression for genes affiliated with Hypersplenism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

Pathways for genes affiliated with Hypersplenism

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50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 30KEGG, 60Thomson Reuters, 12EMD Millipore, 55Reactome, 5Cell Signaling Technology, 61Tocris Bioscience
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Pathways related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.6FOXP3, IL2RA, CSF2
2
Show member pathways
9.6FOXP3, IL2RA, CSF2
3
Show member pathways
9.5CD4, IL2RA, PIK3R1
4
Show member pathways
9.4F2, PIK3R1, THPO, IL2RA
59.4CD4, CSF3, CSF2
69.1IL7R, IL2RA, RELA
7
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.1PIK3R1, RELA, REL
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.1REL, RELA, PIK3R1
99.1REL, RELA, PIK3R1
109.1REL, RELA, PIK3R1
11
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1REL, RELA, PIK3R1
12
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.1REL, RELA, PIK3R1
13
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.1REL, RELA, PIK3R1
149.0TLR4, RELA, REL
15
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0REL, RELA, TLR4
169.0PIK3R1, RELA, CSF2
17
Show member pathways
9.0IL2RA, RELA, PIK3R1
18
Show member pathways
8.9CSF2, RELA, TLR4
19
Show member pathways
thioredoxin pathway38
8.9F2, RELA, ALB
20
Show member pathways
8.9PIK3R1, TLR4, RELA
21
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.8RELA, REL, IL2RA, CD4
22
Show member pathways
8.8F2, PIK3R1, THPO, SERPINC1, ALB
23
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.8PIK3R1, RELA, REL, CD4
24
Show member pathways
8.8CD4, REL, RELA, PIK3R1
25
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.8CSF2, REL, RELA, PIK3R1
26
Show member pathways
Immune response IL 3 activation and signaling pathway60
8.8PIK3R1, RELA, REL, IL2RA
27
Show member pathways
IL2 signaling events mediated by STAT538
8.7IL2RA, FOXP3, RELA, PIK3R1
288.7PIK3R1, RELA, IL2RA, CSF2
29
Show member pathways
8.7PIK3R1, TLR4, RELA, FOXP3
308.6PIK3R1, TLR4, RELA, CSF2
31
Show member pathways
8.6PIK3R1, TLR4, RELA, IL2RA
32
Show member pathways
8.6IL2RA, RELA, TLR4, PIK3R1
33
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6F2, PIK3R1, RELA, REL, CD4
34
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.5PIK3R1, THPO, RELA, IL2RA, IL7R
35
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.5PIK3R1, RELA, REL, CSF2, CD4
36
Show member pathways
8.5PIK3R1, THPO, TLR4, RELA, REL
378.4RELA, EPO, TLR4, PIK3R1
38
Show member pathways
8.4PIK3R1, RELA, IL2RA, IL7R, CSF2
39
Show member pathways
8.4PIK3R1, RELA, IL2RA, IL7R, CSF2
40
Show member pathways
8.4CD4, EVL, RELA, PIK3R1
41
Show member pathways
8.4F2, PIK3R1, THPO, EPO, IL2RA, IL7R
42
Show member pathways
Type III interferon signaling38
8.3PIK3R1, EPO, IL2RA, IL7R, CSF2, CSF3
43
Show member pathways
8.2PIK3R1, THPO, IL2RA, IL7R, CSF2, CSF3
44
Show member pathways
8.2PIK3R1, THPO, IL2RA, IL7R, CSF2, CSF3
45
Show member pathways
8.2CD4, EVL, REL, RELA, PIK3R1
468.1CD4, THPO, EPO, IL2RA, IL7R, CSF2
47
Show member pathways
7.9TLR4, RELA, REL, FOXP3, CSF2, CSF3
48
Show member pathways
7.8PIK3R1, THPO, TLR4, IL2RA, IL7R, CSF2
497.3PIK3R1, TLR4, EPO, RELA, IL2RA, IL7R
50
Show member pathways
6.5F2, PIK3R1, TLR4, EPO, RELA, IL2RA

Compounds for genes affiliated with Hypersplenism

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 3BitterDB, 61Tocris Bioscience, 24HMDB
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Compounds related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1anagrelide45 1110.9THPO, CSF2, EPO
2mafosfamide459.8CSF3, THPO, CSF2
3hepaplastin459.7SERPINC1, ALB, F2
4tranexamic acid45 1110.7F2, EPO, SERPINC1
5phenprocoumon45 51 1111.7F2, SERPINC1, ALB
6pegfilgrastim45 1110.6CSF2, CSF3, EPO
7epsilon aminocaproic acid459.4SERPINC1, F2, EPO
8pixy321459.4CSF3, EPO, THPO, CSF2
9amifostine45 1110.4CSF3, EPO, THPO, CSF2
10filgrastim45 1110.4THPO, CSF2, CSF3, EPO
11gm-csf45 2910.4THPO, EPO, CSF2, CSF3
12anti-fungal459.4CSF3, CSF2, TLR4, REL
13methylcellulose459.4CSF3, CSF2, THPO, EPO
14polyethylene glycol459.4SERPINC1, F2, THPO, ALB
15chloroquine45 3 51 29 1113.3SERPINC1, TLR4, CD4, IL2RA
16hydroxyethyl starch459.3SERPINC1, CSF3, F2, ALB
17carboplatin45 51 1111.2EPO, CSF3, CSF2, THPO
18hydroxyurea45 51 1111.2CSF3, F2, CSF2, THPO, EPO
19bleomycin45 1110.2CSF2, EPO, IL2RA, CSF3
20etoposide45 51 61 1112.0PIK3R1, IL2RA, CSF2, CSF3, THPO
21mycophenolate mofetil45 51 1111.0ALB, CSF3, EPO, IL2RA
22aminoguanidine45 29 1111.0TLR4, EPO, ALB
23genistein45 29 61 3 24 1114.0PIK3R1, IL2RA, TLR4, CSF2, THPO, CD4
24pge2458.9CSF2, FOXP3, TLR4, SERPINC1, IL2RA, CD4
25fibrinogen458.9ALB, SERPINC1, TLR4, THPO, F2
26aspirin45 51 29 2411.8GBA, F2, THPO, TLR4, SERPINC1, IL2RA
27zidovudine45 51 1110.8CD4, ALB, CSF2, EPO, CSF3
28imatinib45 51 1110.8THPO, PIK3R1, EPO, CSF3, ALB
29polysaccharide458.7TLR4, THPO, SERPINC1, CSF2, GBA, IL2RA
30estrogen458.7CSF2, PIK3R1, IL2RA, F2, THPO, SERPINC1
31histamine45 29 2410.7THPO, TLR4, IL2RA, ALB, CSF2
32lactate458.7ALB, EPO, F2, TLR4, THPO, CSF2
33creatinine458.7F2, IL2RA, SERPINC1, EPO, ALB, THPO
34calcitriol45 61 24 1111.7CSF2, IL2RA, EPO, TLR4, F2, ALB
35rantes458.6CD4, CSF3, CSF2, REL, THPO, IL2RA
36vitamin d458.6ALB, TLR4, EPO, CSF2, IL2RA
37phospholipid458.6PIK3R1, IL2RA, TLR4, GBA, F2
38gp 130458.5CSF3, CSF2, IL7R, PIK3R1, THPO, EPO
39aspartate458.5EPO, ALB, IL2RA, TLR4, PIK3R1, F2
40thymidine45 249.5PIK3R1, GBA, IL2RA, CSF2, EPO, CSF3
41heparin45 29 24 1111.4THPO, CSF2, IL7R, IL2RA, SERPINC1, F2
42cysteine458.3CSF2, ALB, CD4, IL2RA, REL, TLR4
43phosphatidylinositol458.3CD4, CSF2, IL7R, IL2RA, EPO, THPO
44cyclosporin a45 29 6110.2F2, REL, FOXP3, IL2RA, CSF2, CSF3
45methotrexate51 45 1110.2F2, TLR4, EPO, IL2RA, ALB, CSF3
46dexamethasone45 51 29 1111.2CSF2, REL, CSF3, SERPINC1, IL2RA, TLR4
47vegf458.0THPO, PIK3R1, CSF3, TLR4, SERPINC1, EPO
48testosterone45 61 24 1110.7EPO, IL2RA, ALB, PIK3R1, SERPINC1, RELA
49serine457.7PIK3R1, RELA, F2, GBA, CD4, REL
50tyrosine457.6EPO, REL, IL2RA, IL7R, CSF2, CD4

GO Terms for genes affiliated with Hypersplenism

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16Gene Ontology
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Cellular components related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4ALB, SERPINC1, F2
2external side of plasma membraneGO:0098979.1TLR4, IL2RA, IL7R, CD4
3extracellular regionGO:0055768.0F2, SERPINC1, EPO, IL7R, CSF2, ALB
4extracellular spaceGO:0056157.9ALB, CSF3, CSF2, EPO, SERPINC1, THPO

Biological processes related to Hypersplenism according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immune responseGO:05077710.1FOXP3, IL2RA
2cytokine productionGO:00181610.0REL, FOXP3, CD4
3macrophage activationGO:04211610.0TLR4, CSF2
4negative regulation of neuron deathGO:19012159.9CSF3, REL
5negative regulation of interleukin-6 productionGO:0327159.9FOXP3, TLR4, GBA
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9CSF2, EPO
7negative regulation of osteoclast differentiationGO:0456719.8TLR4, PIK3R1
8negative regulation of interferon-gamma productionGO:0326899.8FOXP3, TLR4
9negative regulation of inflammatory responseGO:0507289.8IL2RA, SERPINC1, GBA
10response to testosteroneGO:0335749.7EPO, GBA
11defense response to Gram-negative bacteriumGO:0508299.5CD4, TLR4
12platelet activationGO:0301689.4F2, PIK3R1, THPO, ALB
13positive regulation of interleukin-12 biosynthetic processGO:0450849.4TLR4, RELA, REL
14cell surface receptor signaling pathwayGO:0071669.1CD4, EVL, IL7R, IL2RA, F2
15T cell receptor signaling pathwayGO:0508529.1PIK3R1, RELA, FOXP3, CD4
16blood coagulationGO:0075969.1F2, PIK3R1, THPO, SERPINC1, ALB
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1TLR4, RELA, REL
18cellular response to lipopolysaccharideGO:0712228.7TLR4, RELA, CSF2, CSF3
19immune responseGO:0069558.7CD4, CSF3, CSF2, IL7R, IL2RA, TLR4
20positive regulation of transcription, DNA-templatedGO:0458938.7EPO, RELA, REL, FOXP3
21positive regulation of cell proliferationGO:0082848.4CSF3, CSF2, RELA, EPO, F2
22positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CSF3, FOXP3, RELA, TLR4, PIK3R1

Molecular functions related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NF-kappaB bindingGO:0510599.4FOXP3, RELA
2cytokine activityGO:0051259.1CSF3, CSF2, THPO
3growth factor activityGO:0080839.1F2, THPO, CSF2, CSF3
4protein bindingGO:0055155.1CD4, GBA, F2, PIK3R1, TLR4, SERPINC1

Products for genes affiliated with Hypersplenism

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Sources for Hypersplenism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet