MCID: HYP063
MIFTS: 52

Hypersplenism malady

Immune, Blood categories

Summaries for Hypersplenism

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards: Hypersplenism, also known as hypersplenia, is related to splenomegaly and portal hypertension. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are TGF-beta Signaling Pathways and Cytokines and Inflammatory Response. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are renal/urinary system and respiratory system.

Aliases & Classifications for Hypersplenism

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Blood


Aliases & Descriptions:

hypersplenism 8 10 45 61
hypersplenia 8


External Ids:

Disease Ontology8 DOID:6376
ICD9CM27 289.4
MeSH35 D006971
NCIt40 C34714
ICD1025 D73.1

Related Diseases for Hypersplenism

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypersplenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1splenomegaly31.0CSF3, EPO, GBA, IL2RA, THPO
2portal hypertension30.9F2, THPO, ALB
3thrombocytopenia30.7GBA, IL11, F2, THPO, SERPINC1, ALB
4hepatitis c30.3THPO, F2, TLR4
5pancytopenia30.3CSF2, CSF3, EPO, GBA, IL2RA, THPO
6sickle cell disease30.2EPO
7thalassemia30.2EPO
8tuberculosis30.1TLR4, CD4, IL2RA, IL11, ALB
9felty's syndrome30.0CSF2, CSF3
10portal vein thrombosis30.0F2, THPO, SERPINC1
11acquired immunodeficiency syndrome30.0ALB, CD4, CSF2
12cystic fibrosis30.0TLR4, CD4, ALB
13acute leukemia30.0CSF2, CSF3, EPO, IL11, THPO
14arthritis30.0ALB, CD4, FOXP3, CSF2, TLR4
15peripheral vascular disease29.8ALB
16acquired thrombocytopenia29.8THPO, IL11
17colorectal cancer29.8CD4
18stomatitis29.8CSF2, CSF3, IL11
19vascular disease29.8CD4, SERPINC1
20myeloproliferative disorder29.8THPO, IL11, EPO, CSF3, CSF2
21splenic disease10.3
22gaucher's disease10.2
23sickle cell anemia10.2
24hepatitis c virus10.2
25hepatitis e10.1
26lymphosarcoma10.1
27biliary atresia10.0
28splenic sequestration10.0
29splenic artery aneurysm10.0
30wandering spleen10.0
31myeloid splenomegaly10.0
32viral hepatitis10.0F2
33endometriosis10.0IL11
34hepatitis a10.0F2
35obesity10.0PIK3R1
36periodontitis10.0TLR4
37pancreatic cancer10.0PIK3R1
38acute pancreatitis10.0TLR4
39chorioamnionitis10.0TLR4
40chronic myeloproliferative disease10.0THPO
41multiple myeloma10.0CSF3
42colon cancer10.0PIK3R1
43crohn's disease10.0ALB
44pyelonephritis10.0TLR4
45dementia10.0GBA
46atopy10.0TLR4
47von willebrand's disease10.0F2
48hydrops fetalis10.0GBA
49capillary leak syndrome10.0CSF2
50rhinitis10.0ALB

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to hypersplenism

Clinical Features for Hypersplenism

Drugs & Therapeutics for Hypersplenism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypersplenism

Drug clinical trials:

Search ClinicalTrials for Hypersplenism

Search NIH Clinical Center for Hypersplenism

Search CenterWatch for Hypersplenism

Genetic Tests for Hypersplenism

Anatomical Context for Hypersplenism

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypersplenism:

33
Bone marrow, Whole blood, Spleen, Brain, Liver, Pancreas, Breast, Myeloid, T cells, B cells, Pineal

Animal Models for Hypersplenism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hypersplenism

Sources:
51PubMed
See all sources

Articles related to Hypersplenism:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
Thermal ablation for partial splenectomy hemostasis, spleen trauma, splenic metastasis and hypersplenism. (23159352)
2013
2
Peripheral blood cell variations in cirrhotic portal hypertension patients with hypersplenism. (23790341)
2013
3
Warren shunt combined with partial splenectomy for children with extrahepatic portal hypertension, massive splenomegaly, and severe hypersplenism. (23132324)
2013
4
Safety and efficacy of splenic artery coil embolization for hypersplenism in liver cirrhosis. (22855417)
2012
5
Partial splenic embolization using Bletilla striata particles for hypersplenism in cirrhosis: a prospective study. (21476204)
2011
6
Change in platelet count in patients with hypersplenism subjected to liver transplantation. (21952701)
2011
7
Laparoscopic splenectomy is an effective and safe intervention for hypersplenism secondary to liver cirrhosis. (21681623)
2011
8
Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenism. (19929930)
2010
9
Laparoscopic splenectomy and azygoportal disconnection for bleeding varices with hypersplenism. (18266572)
2008
10
MicroRNAome of splenic macrophages in hypersplenism due to portal hypertension in hepatitis B virus-related cirrhosis. (18791127)
2008
11
Comparison of two different percutaneous splenic artery interventions in the treatment of hypersplenism: preliminary report. (15848633)
2005
12
Accessory splenectomy with gastroesophageal devascularization for recurrent hypersplenism and refractory bleeding varices in a patient with liver cirrhosis: report of a case. (15580390)
2004
13
Hypersplenism induced by hepatectomy. (11490826)
2001
14
A new surgical strategy for cirrhotic patients with hepatocellular carcinoma and hypersplenism. Performing a hepatectomy after a laparoscopic splenectomy. (10656943)
2000
15
Effect of transjugular intrahepatic portosystemic shunt on secondary hypersplenism. (9124620)
1997
16
Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis. (8946990)
1996
17
Partial splenic embolization decreases the serum bilirubin level in patients with hypersplenism following the Kasai procedure for biliary atresia. (8603238)
1996
18
The use of granulocyte-macrophage colony-stimulating factor to enhance hematologic parameters of patients with cirrhosis and hypersplenism. (7814805)
1994
19
Partial splenic embolization in children with hypersplenism. (8283383)
1994
20
Splenic lymphoma with hypersplenism--a case report. (2185555)
1990
21
Reversal of hypersplenism following orthotopic liver transplantation. (2667473)
1989
22
Partial splenic embolisation for hypersplenism of thalassaemia major: five year follow up. (3105679)
1987
23
Partial splenic embolization: a treatment for hypersplenism. (3988493)
1985
24
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 48-1985. A 69-year-old man with peripheral vascular disease and hypersplenism. (4058534)
1985
25
Portal hypertension and hypersplenism in pregnancy secondary to chronic schistosomiasis. A case report. (6726707)
1984
26
Effect of portacaval anastomosis on hypersplenism. (7004809)
1980
27
Isoniazid-related liver disease. Occurrence with portal hypertension, hypoalbuminemia, and hypersplenism. (448941)
1979
28
Posttransplant hypersplenism. (377730)
1979
29
Effect of portasystemic shunt on hypersplenism: clinical study in 129 patients with cirrhosis. (464392)
1979
30
Control of hypersplenism and painful splenomegaly in myeloid metaplasia by irradiation. (413815)
1977
31
The effect of portacaval shunt on hypersplenism. (4419559)
1974
32
Hypersplenism: mechanisms and management. (4604547)
1974
33
Splenectomy for hypersplenism in malignant lymphoma. (4916017)
1970
34
Scan evidence of organ involution and improvement of hypersplenism in Hodgkin's disease following splenic artery ligation. (5476931)
1970
35
SPLENECTOMY FOR HYPERSPLENISM IN SICKLE CELL ANEMIA. (14078086)
1963
36
Erythrokinetic studies in primary hypersplenism with pancytopenia. (13898144)
1962
37
Hypersplenism and bilharziasis. (13860839)
1961
38
Influence of spleen on thrombocytopenia induced by humoral factor(s) of experimental hypersplenism. (14485324)
1961
39
Spleno-renal anastomosis for hepatic cirrhosis with hypersplenism in a case of fibrocystic disease (mucoviscidosis). (13843860)
1960
40
Intermittent fever over a 17-year period in a patient with hypersplenism due to brucellosis. (14442818)
1959
41
Hypersplenism. (13230762)
1955
42
Hereditary ovalocytosis (elliptocytosis) with hypersplenism. (14349422)
1955
43
Hypersplenism indications for surgery. (13173138)
1954
44
Recurrent hypersplenism due to accessory spleen. (13157891)
1953
45
Pancreatic cyst; an unusual cause of hypersplenism. (12996227)
1952
46
Symposium on hypersplenism. (13000107)
1952
47
Pregnancy complicated by hypersplenism. (12985698)
1952
48
Hypersplenism associated with follicular lymphoblastoma; report of a case with splenectomy. (15404070)
1950
49
THE concept of hypersplenism. (20273939)
1946
50
HYPERSPLENISM AND HYPOSPLENISM AND SPLENECTOMY. (20774640)
1929

Genetic Variations for Hypersplenism

Expression for genes affiliated with Hypersplenism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

Pathways for genes affiliated with Hypersplenism

Sources:
53R&D Systems, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology, 60Tocris Bioscience
See all sources

Pathways related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2REL
210.1CD4
39.9IL7R, PIK3R1
4
Hide members
9.8ALB, THPO, F2
5
Hide members
9.5TLR4, PIK3R1, REL, THPO
6
Hide members
9.5CSF2, FOXP3, IL2RA
7
Hide members
9.5IL2RA, FOXP3, CSF2
89.5RELA, F2, ALB
99.5TLR4, CSF2, IL11
109.5TLR4, CSF2, RELA
11
Immune response ICOS pathway in T-helper cell
Hide members
9.4REL, RELA, PIK3R1
129.4REL, RELA, PIK3R1
13
Transcription Androgen Receptor nuclear signaling
Hide members
9.4PIK3R1, RELA, REL
149.4PIK3R1, RELA, REL
15
Hide members
9.4REL, RELA, PIK3R1
16
Immune response NFAT in immune response
Hide members
9.4REL, RELA, PIK3R1
17
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.4TLR4, RELA, REL
189.4TLR4, RELA, REL
19
Immune response Bacterial infections in normal airways
9.4REL, RELA, TLR4
209.4REL, RELA, TLR4
219.3REL, RELA, CD4
22
Hide members
9.3IL7R, IL2RA, PIK3R1, CSF2
23
Hide members
9.3CSF2, PIK3R1, IL2RA, IL7R
249.2RELA, PIK3R1, CSF2, TLR4
259.2IL7R, IL2RA, RELA
269.2TLR4, PIK3R1, EPO, RELA
279.2PIK3R1, RELA, IL11
28
Hide members
9.2CSF2, PIK3R1, RELA, REL
29
Hide members
9.1TLR4, FOXP3, PIK3R1, RELA
30
Hide members
9.1IL2RA, RELA, PIK3R1, TLR4
319.1CSF2, PIK3R1, RELA, IL2RA
32
Hide members
9.0REL, RELA, CD4, PIK3R1
33
Immune response IL-2 activation and signaling pathway
Hide members
9.0PIK3R1, RELA, REL, IL2RA
34
Hide members
9.0FOXP3, PIK3R1, RELA, IL2RA
35
Hide members
9.0CD4, IL2RA, IL7R, F2, THPO
368.9TLR4, RELA, REL, IL11
37
Hide members
8.9CD4, RELA, REL, IL2RA
38
Development PDGF signaling via STATs and NF-kB
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8.8PIK3R1, CD4, RELA, REL, F2
39
Hide members
8.8CSF2, PIK3R1, CD4, RELA, REL
40
Hide members
8.8PIK3R1, RELA, IL2RA, IL7R, THPO
41
Hide members
8.7PIK3R1, CD4, RELA, EVL
42
Hide members
8.6CSF2, PIK3R1, CD4, IL11, IL7R, THPO
43
Cytokine production by Th17 cells in CF (Mouse model)
8.0TLR4, CSF2, CSF3, FOXP3, RELA, REL
44
Hide members
7.8TLR4, CSF2, PIK3R1, CD4, RELA, REL
457.7TLR4, CSF3, PIK3R1, EPO, RELA, IL2RA
467.6CSF2, CSF3, PIK3R1, EPO, IL2RA, IL11
47
Hide members
7.5CSF2, CSF3, PIK3R1, CD4, IL2RA, IL11
487.3THPO, CSF2, CSF3, CD4, EPO, IL2RA
49
Hide members
7.3TLR4, CSF2, CSF3, PIK3R1, CD4, IL2RA
50
Hide members
7.1TLR4, CSF2, CSF3, PIK3R1, CD4, IL2RA

Compounds for genes affiliated with Hypersplenism

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5THPO
2pge24510.2CD4, CSF2
3gm-csf45 2911.2THPO, IL11
4dexamethasone45 50 29 1113.1PIK3R1, REL, TLR4
5anagrelide45 1111.0THPO, EPO, CSF2
6hepaplastin459.9ALB, F2, SERPINC1
7phenprocoumon45 50 1111.6SERPINC1, ALB, F2
8aspartate459.6IL11, PIK3R1, ALB, F2
9pegfilgrastim45 1110.5EPO, CSF3, CSF2
10mafosfamide459.5THPO, CSF2, CSF3
11tranexamic acid45 1110.4EPO, F2, SERPINC1
12hyaluronic acid45 2410.3ALB, F2, THPO, IL11, CSF2
13polyethylene glycol459.2F2, THPO, ALB, IL11, SERPINC1
14il 11459.2IL11, CSF3, EPO
15heparin45 29 11 2412.2CSF2, CD4, IL2RA, THPO, IL11
16hydroxyethyl starch459.1CSF3, F2, SERPINC1, ALB
17serine459.1CD4, TLR4, PIK3R1, GBA
18hydroxyurea45 50 1111.1CSF3, THPO, F2, EPO, CSF2
19anti-fungal459.0CSF3, CSF2, TLR4, REL
20lactate459.0TLR4, CSF2, EPO, THPO, ALB, F2
21ifosfamide45 1110.0CSF2, IL11, THPO, CSF3
22aspirin45 50 29 2411.9IL2RA, GBA, F2, CSF2, SERPINC1, THPO
23herbimycin a45 609.9CSF2, IL7R, IL11, CD4, IL2RA
24genistein45 29 60 2 11 2413.9IL2RA, THPO, CD4, CSF2, PIK3R1, TLR4
25fibrinogen458.9TLR4, IL11, F2, THPO, ALB, SERPINC1
26imatinib45 50 1110.9CSF3, PIK3R1, EPO, ALB, THPO
27tacrolimus45 50 1110.9ALB, IL11, IL2RA, TLR4, REL
28histamine45 29 2410.9THPO, ALB, TLR4, IL2RA, CSF2, IL11
29pixy321458.9THPO, CSF3, IL11, EPO, CSF2
30zidovudine45 119.9ALB, EPO, CD4, CSF3, CSF2
31amifostine45 119.9CSF2, EPO, THPO, IL11, CSF3
32filgrastim45 119.8THPO, IL11, EPO, CSF3, CSF2
33methylcellulose458.8CSF3, IL11, THPO, CSF2, EPO
34vitamin d458.8IL2RA, TLR4, EPO, IL11, ALB, CSF2
35carboplatin45 50 1110.8CSF2, CSF3, THPO, IL11, EPO
36cytarabine45 50 1110.8EPO, IL11, CSF3, CSF2, THPO
37calcitriol45 60 11 2411.7TLR4, ALB, F2, IL11, IL2RA, EPO
38polysaccharide458.7THPO, TLR4, CSF2, CD4, GBA, IL2RA
39methotrexate45 50 1110.6GBA, CSF3, IL2RA, F2, ALB, EPO
40arachidonic acid45 29 11 2411.6THPO, ALB, IL11, CD4, CSF2, TLR4
41mycophenolate mofetil45 50 1110.6ALB, IL11, CSF3, IL2RA, EPO
42etoposide45 50 60 1111.4CSF3, PIK3R1, CSF2, THPO, IL11, IL2RA
43phosphatidylinositol458.1CSF2, CD4, EPO, IL2RA, IL11, TLR4
44cysteine458.1IL2RA, ALB, TLR4, THPO, IL11, CD4
45vegf458.0SERPINC1, IL2RA, EPO, PIK3R1, CSF3, CSF2
46thymidine45 249.0EPO, PIK3R1, CSF2, GBA, THPO, IL2RA
47gp 130457.9PIK3R1, THPO, CSF2, CSF3, EPO, IL2RA
48rantes457.8TLR4, CSF2, CD4, REL, IL2RA, IL11
49cyclosporin a45 29 609.5CSF3, TLR4, F2, IL11, IL2RA, REL
50tyrosine456.9THPO, IL7R, CD4, IL11, IL2RA, PIK3R1

GO Terms for genes affiliated with Hypersplenism

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.8IL7R, IL2RA, CD4, TLR4
2extracellular regionGO:0055768.2CSF2, EPO, IL11, IL7R, F2, SERPINC1
3extracellular spaceGO:0056157.4THPO, IL11, SERPINC1, ALB, EPO, CSF3

Biological processes related to Hypersplenism according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.9TLR4, FOXP3, GBA
2negative regulation of immune responseGO:0507779.7IL2RA, FOXP3
3positive regulation of interleukin-12 biosynthetic processGO:0450849.7REL, RELA, TLR4
4macrophage activationGO:0421169.7CSF2, TLR4
5cytokine productionGO:0018169.6FOXP3, CD4, REL
6negative regulation of inflammatory responseGO:0507289.5GBA, IL2RA, SERPINC1
7platelet activationGO:0301689.3ALB, THPO, F2, IL11, PIK3R1
8T cell receptor signaling pathwayGO:0508529.2RELA, CD4, PIK3R1, FOXP3
9blood coagulationGO:0075969.1ALB, SERPINC1, THPO, F2, PIK3R1
10cellular response to lipopolysaccharideGO:0712228.9TLR4, CSF2, CSF3, RELA
11cell surface receptor signaling pathwayGO:0071668.8CD4, IL2RA, IL7R, F2, EVL
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.7CSF3, CD4, IL11
13immune responseGO:0069558.3TLR4, CSF2, CSF3, CD4, IL2RA, IL7R
14positive regulation of cell proliferationGO:0082848.1CSF2, CSF3, EPO, RELA, IL11, F2
15positive regulation of transcription from RNA polymerase II promoterGO:0459447.9IL11, RELA, PIK3R1, FOXP3, CSF3, TLR4

Molecular functions related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7THPO, IL11, CSF3, CSF2
2growth factor activityGO:0080838.4THPO, F2, IL11, CSF3, CSF2
3protein bindingGO:0055155.7CD4, PIK3R1, FOXP3, CSF2, TLR4, EPO

Products for genes affiliated with Hypersplenism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypersplenism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet