MCID: HYP063
MIFTS: 56

Hypersplenism malady

Immune diseases, Blood diseases categories

Summaries for Hypersplenism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards: Hypersplenism, also known as hypersplenia, is related to hypertension and portal hypertension. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are TGF-beta Signaling Pathways and Cytokines and Inflammatory Response. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone, and related mouse phenotypes are renal/urinary system and respiratory system.

Aliases & Classifications for Hypersplenism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

hypersplenism 8 10 44 60
hypersplenia 8


External Ids:

Disease Ontology8 DOID:6376
ICD9CM27 289.4
MeSH34 D006971
NCIt39 C34714
ICD1025 D73.1

Related Diseases for Hypersplenism

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17GeneCards, 18GeneDecks
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Diseases related to Hypersplenism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9F2, ALB
2portal hypertension30.8F2, THPO, ALB
3hepatitis30.6ALB, THPO, F2
4liver cirrhosis30.6IL11, F2, THPO, SERPINC1, ALB
5thrombocytopenia30.6GBA, IL11, F2, THPO, SERPINC1, ALB
6hepatocellular carcinoma30.6TLR4, FOXP3, PIK3R1, CD4, F2, ALB
7hepatitis c30.4THPO, F2, TLR4
8pancytopenia30.2CSF2, CSF3, EPO, GBA, IL2RA, THPO
9sickle cell disease30.2EPO
10leukemia30.1TLR4, CSF2, CSF3, FOXP3, PIK3R1, CD4
11pancreatitis30.1IL11, ALB
12tuberculosis30.1TLR4, CD4, IL2RA, IL11, ALB
13hepatitis a30.0F2
14myelofibrosis30.0EPO, THPO
15felty's syndrome30.0CSF2, CSF3
16portal vein thrombosis30.0F2, THPO, SERPINC1
17acquired immunodeficiency syndrome30.0ALB, CD4, CSF2
18severe combined immunodeficiency30.0IL2RA, IL7R
19cystic fibrosis30.0TLR4, CD4, ALB
20acute leukemia30.0CSF2, CSF3, EPO, IL11, THPO
21sarcoidosis30.0CD4, IL2RA
22hepatitis b30.0IL2RA, F2, ALB
23arthritis29.9ALB, CD4, FOXP3, CSF2, TLR4
24alpha thalassemia29.7EPO
25peripheral vascular disease29.7ALB
26polycythemia29.7EPO, THPO
27acquired thrombocytopenia29.7THPO, IL11
28colorectal cancer29.7CD4
29candidiasis29.7CD4
30schistosomiasis29.7CD4
31purpura29.7THPO, SERPINC1
32lupus erythematosus29.7SERPINC1, F2
33stomatitis29.7CSF2, CSF3, IL11
34malaria29.7ALB, CD4
35gastritis29.7CD4, TLR4
36vascular disease29.7CD4, SERPINC1
37neutropenia29.7THPO, IL11, EPO, CSF3, CSF2
38splenomegaly29.7CSF3, EPO, GBA, IL2RA, THPO
39hodgkin's lymphoma29.7CSF2, CSF3, PIK3R1, REL, IL2RA
40t-cell leukemia29.7FOXP3, CD4, RELA, REL, IL2RA
41liver disease10.3
42splenic disease10.3
43sickle cell anemia10.1
44gaucher's disease10.1
45lymphosarcoma10.1
46biliary atresia10.0
47splenic sequestration10.0
48splenic artery aneurysm10.0
49esophagitis10.0
50hemolytic anemia10.0

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to hypersplenism

Clinical Features for Hypersplenism

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Drugs & Therapeutics for Hypersplenism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypersplenism

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Anatomical Context for Hypersplenism

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32MalaCards
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MalaCards organs/tissues related to Hypersplenism:

32
Spleen, Liver, Bone, Bone marrow, T cells, Myeloid, Testes, B cells, Pineal, Brain, Pancreas, Breast

Animal Models for Hypersplenism or affiliated genes

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36MGI
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Publications for Hypersplenism

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50PubMed
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Articles related to Hypersplenism:

(show top 50)    (show all 423)
idTitleAuthorsYear
1
Lipogranulomatosis and hypersplenism induced by ruptured silicone breast implants. (24228267)
2013
2
Commentary on "Prophylaxis against HBV recurrence after liver transplantation for HBV-related endstage liver diseases with severe hypersplenism and splenomegaly: Role of splenectomy". (22640889)
2013
3
Prophylaxis against hepatitis B virus recurrence after liver transplantation for hepatitis B virus-related end-stage liver diseases with severe hypersplenism and splenomegaly: role of splenectomy. (22483806)
2012
4
A novel canine model of portal vein stenosis plus thioacetamide administration-induced cirrhotic portal hypertension with hypersplenism. (21904911)
2012
5
Formula to predict platelet count after partial splenic arterial embolization in patients with hypersplenism. (22633618)
2012
6
Microwave ablation in the spleen for treatment of secondary hypersplenism: a preliminary study. (21343515)
2011
7
Knockdown of PIK3R1 by shRNA inhibits the activity of the splenic macrophages associated with hypersplenism due to portal hypertension. (20846792)
2010
8
Life-threatening hypersplenism due to idiopathic portal hypertension in early childhood: case report and review of the literature. (20961440)
2010
9
Recurrent hypersplenism caused by giant accessory spleen due to portal hypertension after splenectomia. (19995153)
2010
10
Significance of laparoscopic splenectomy in patients with hypersplenism. (17308852)
2007
11
Partial Splenic Embolization: successful treatment of hypersplenism, secondary to biliary cirrhosis and portal hypertension in cystic fibrosis. (17157565)
2007
12
Radiotherapy for hypersplenism from congestive splenomegaly. (15307459)
2004
13
Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. (12753144)
2003
14
Massive splenomegaly and hypersplenism in a young woman with primary SjAPgren's syndrome. (12233900)
2002
15
C3H mice have larger spleens, lower platelet counts, and shorter platelet lifespans than C57BL mice: an animal model for the study of hypersplenism. (9293898)
1997
16
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism...". (8855767)
1996
17
Effect of granulocyte colony-stimulating factor on neutropenia in liver transplant recipients with hypersplenism. (7516966)
1994
18
Preoperative embolization of the spleen in children with hypersplenism. (1446126)
1992
19
Hypersplenism secondary to a ruptured gallbladder and a pericholecystic abscess that presented as staphylococcal septicemia. (3949560)
1986
20
The 'spent' phase of polycythaemia vera: hypersplenism in the absence of myelofibrosis. (6584168)
1984
21
Percutaneous splenic artery occlusion for portal hypertension. A new mechanical technique for hypersplenism. (6870519)
1983
22
Evaluation of splenic embolization in patients with portal hypertension and hypersplenism. (7125739)
1982
23
Right splenorenal fusion with associated hypersplenism. (7321133)
1981
24
Pancreatic pseudocyst with unusual complications: perforation of portal and splenic veins and hypersplenism. (6929426)
1980
25
The effect of intravenous injection of ethyl palmitate emulsion on sequestration of thermally damaged erythrocytes in rats with experimentally induced hypersplenism, and in normal rats. (91558)
1979
26
Experimental hypersplenism in mice. (131348)
1976
27
Treatment of hypersplenism by embolus placement in the splenic artery. (63745)
1976
28
Splenectomy or radiation and splenectomy for hypersplenism in lymphosarcoma. (946674)
1976
29
Pathophysiology of "hypersplenism syndrome". Remarks about definition and estimation of the splenic erythrocyte pool. (4756432)
1973
30
Hypersplenism due to disseminated candidiasis in a patient with acute leukemia. (5256261)
1969
31
'Non-tropical idiopathic splenomegaly' ('primary hypersplenism'): a review of ten cases and their relationship to malignant lymphomas. (5394584)
1969
32
The pathogenesis of thrombocytopenia in hypersplenism. (5679134)
1968
33
Progressive hypersplenism after portacaval anastomosis. Report of 3 cases. (6017998)
1967
34
Blood changes and fertility derangements following the injection of Candida albicans into the spleen of the experimental animals (occurrence of hypersplenism). (5973429)
1966
35
SPLENECTOMY FOR HYPERSPLENISM SECONDARY TO MALIGNANCY. (14133345)
1964
36
Splenectomy for hypersplenism in Hodgkin's disease. A reappraisal. (14494560)
1962
37
An attempt to produce hypersplenism in the dog, using methylcellulose. (13784140)
1961
38
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
39
Hypersplenism in geriatrics. (13428525)
1957
40
Hypersplenism; report of two cases. (13202668)
1954
41
Hypersplenism: leukopenic-thrombopenic syndrome; report of two cases. (13154164)
1954
42
Hypersplenism associated with hamartomas of the spleen. (13091739)
1953
43
CASES from the medical grand rounds, Massachusetts General Hospital: hypersplenism. (12986141)
1952
44
Surgical aspects of hypersplenism. (14917553)
1952
45
Hypersplenism. (14841608)
1951
46
Hypersplenism in infancy and early childhood: a report of three cases. (14836456)
1951
47
Splenomegaly with hypersplenism due to sarcoidosis; report of a case. (14780376)
1950
48
Hypersplenism with arthritis; report of a case. (15396185)
1949
49
Gaucher's disease with thrombocytopenia, an instance of selective hypersplenism. (18109352)
1949
50
The spleen, hypersplenism and the blood dyscrasias. (18863245)
1947

Genetic Variations for Hypersplenism

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Expression for genes affiliated with Hypersplenism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

Pathways for genes affiliated with Hypersplenism

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52R&D Systems, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 59Tocris Bioscience
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Pathways related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2REL
210.1CD4
39.9IL7R, PIK3R1
4
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9.8ALB, THPO, F2
5
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9.5TLR4, PIK3R1, REL, THPO
6
Hide members
9.5CSF2, FOXP3, IL2RA
7
Hide members
9.5IL2RA, FOXP3, CSF2
89.5RELA, F2, ALB
99.5TLR4, CSF2, IL11
109.5TLR4, CSF2, RELA
11
Immune response ICOS pathway in T-helper cell
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9.4REL, RELA, PIK3R1
129.4REL, RELA, PIK3R1
13
Transcription Androgen Receptor nuclear signaling
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9.4PIK3R1, RELA, REL
149.4PIK3R1, RELA, REL
15
Hide members
9.4REL, RELA, PIK3R1
16
Immune response NFAT in immune response
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9.4REL, RELA, PIK3R1
17
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.4TLR4, RELA, REL
189.4TLR4, RELA, REL
19
Immune response Bacterial infections in normal airways
9.4REL, RELA, TLR4
209.4REL, RELA, TLR4
219.3REL, RELA, CD4
22
Hide members
9.3IL7R, IL2RA, PIK3R1, CSF2
23
Hide members
9.3CSF2, PIK3R1, IL2RA, IL7R
249.2RELA, PIK3R1, CSF2, TLR4
259.2IL7R, IL2RA, RELA
269.2TLR4, PIK3R1, EPO, RELA
279.2PIK3R1, RELA, IL11
28
Hide members
9.2CSF2, PIK3R1, RELA, REL
29
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9.1TLR4, FOXP3, PIK3R1, RELA
30
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9.1IL2RA, RELA, PIK3R1, TLR4
319.1CSF2, PIK3R1, RELA, IL2RA
32
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9.0REL, RELA, CD4, PIK3R1
33
Immune response IL-2 activation and signaling pathway
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9.0PIK3R1, RELA, REL, IL2RA
34
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9.0FOXP3, PIK3R1, RELA, IL2RA
35
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9.0CD4, IL2RA, IL7R, F2, THPO
368.9TLR4, RELA, REL, IL11
37
Hide members
8.9CD4, RELA, REL, IL2RA
38
Development PDGF signaling via STATs and NF-kB
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8.8PIK3R1, CD4, RELA, REL, F2
39
Hide members
8.8CSF2, PIK3R1, CD4, RELA, REL
40
Hide members
8.8PIK3R1, RELA, IL2RA, IL7R, THPO
41
Hide members
8.7PIK3R1, CD4, RELA, EVL
42
Hide members
8.6CSF2, PIK3R1, CD4, IL11, IL7R, THPO
43
Cytokine production by Th17 cells in CF (Mouse model)
8.0TLR4, CSF2, CSF3, FOXP3, RELA, REL
44
Hide members
7.8TLR4, CSF2, PIK3R1, CD4, RELA, REL
457.7TLR4, CSF3, PIK3R1, EPO, RELA, IL2RA
467.6CSF2, CSF3, PIK3R1, EPO, IL2RA, IL11
47
Hide members
7.5CSF2, CSF3, PIK3R1, CD4, IL2RA, IL11
487.3THPO, CSF2, CSF3, CD4, EPO, IL2RA
49
Hide members
7.3TLR4, CSF2, CSF3, PIK3R1, CD4, IL2RA
50
Hide members
7.1TLR4, CSF2, CSF3, PIK3R1, CD4, IL2RA

Compounds for genes affiliated with Hypersplenism

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypersplenism according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5THPO
2pge24410.2CD4, CSF2
3gm-csf44 2811.2THPO, IL11
4dexamethasone44 49 28 1113.1PIK3R1, REL, TLR4
5anagrelide44 1111.0THPO, EPO, CSF2
6hepaplastin449.9ALB, F2, SERPINC1
7phenprocoumon44 49 1111.6SERPINC1, ALB, F2
8aspartate449.6IL11, PIK3R1, ALB, F2
9pegfilgrastim44 1110.5EPO, CSF3, CSF2
10mafosfamide449.5THPO, CSF2, CSF3
11tranexamic acid44 1110.4EPO, F2, SERPINC1
12hyaluronic acid44 2410.3ALB, F2, THPO, IL11, CSF2
13polyethylene glycol449.2F2, THPO, ALB, IL11, SERPINC1
14il 11449.2IL11, CSF3, EPO
15heparin44 28 11 2412.2CSF2, CD4, IL2RA, THPO, IL11
16hydroxyethyl starch449.1CSF3, F2, SERPINC1, ALB
17serine449.1CD4, TLR4, PIK3R1, GBA
18hydroxyurea44 49 1111.1CSF3, THPO, F2, EPO, CSF2
19anti-fungal449.0CSF3, CSF2, TLR4, REL
20lactate449.0TLR4, CSF2, EPO, THPO, ALB, F2
21ifosfamide44 1110.0CSF2, IL11, THPO, CSF3
22aspirin44 49 28 2411.9IL2RA, GBA, F2, CSF2, SERPINC1, THPO
23herbimycin a44 599.9CSF2, IL7R, IL11, CD4, IL2RA
24genistein44 28 59 2 11 2413.9IL2RA, THPO, CD4, CSF2, PIK3R1, TLR4
25fibrinogen448.9TLR4, IL11, F2, THPO, ALB, SERPINC1
26imatinib44 49 1110.9CSF3, PIK3R1, EPO, ALB, THPO
27tacrolimus44 49 1110.9ALB, IL11, IL2RA, TLR4, REL
28histamine44 28 2410.9THPO, ALB, TLR4, IL2RA, CSF2, IL11
29pixy321448.9THPO, CSF3, IL11, EPO, CSF2
30zidovudine44 119.9ALB, EPO, CD4, CSF3, CSF2
31amifostine44 119.9CSF2, EPO, THPO, IL11, CSF3
32filgrastim44 119.8THPO, IL11, EPO, CSF3, CSF2
33methylcellulose448.8CSF3, IL11, THPO, CSF2, EPO
34vitamin d448.8IL2RA, TLR4, EPO, IL11, ALB, CSF2
35carboplatin44 49 1110.8CSF2, CSF3, THPO, IL11, EPO
36cytarabine44 49 1110.8EPO, IL11, CSF3, CSF2, THPO
37calcitriol44 59 11 2411.7TLR4, ALB, F2, IL11, IL2RA, EPO
38polysaccharide448.7THPO, TLR4, CSF2, CD4, GBA, IL2RA
39methotrexate44 49 1110.6GBA, CSF3, IL2RA, F2, ALB, EPO
40arachidonic acid44 28 11 2411.6THPO, ALB, IL11, CD4, CSF2, TLR4
41mycophenolate mofetil44 49 1110.6ALB, IL11, CSF3, IL2RA, EPO
42etoposide44 49 59 1111.4CSF3, PIK3R1, CSF2, THPO, IL11, IL2RA
43phosphatidylinositol448.1CSF2, CD4, EPO, IL2RA, IL11, TLR4
44cysteine448.1IL2RA, ALB, TLR4, THPO, IL11, CD4
45vegf448.0SERPINC1, IL2RA, EPO, PIK3R1, CSF3, CSF2
46thymidine44 249.0EPO, PIK3R1, CSF2, GBA, THPO, IL2RA
47gp 130447.9PIK3R1, THPO, CSF2, CSF3, EPO, IL2RA
48rantes447.8TLR4, CSF2, CD4, REL, IL2RA, IL11
49cyclosporin a44 28 599.5CSF3, TLR4, F2, IL11, IL2RA, REL
50tyrosine446.9THPO, IL7R, CD4, IL11, IL2RA, PIK3R1

GO Terms for genes affiliated with Hypersplenism

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16Gene Ontology
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Cellular components related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.8TLR4, CD4, IL2RA, IL7R
2extracellular regionGO:0055768.2ALB, SERPINC1, F2, IL7R, IL11, EPO
3extracellular spaceGO:0056157.4ALB, CSF2, CSF3, EPO, IL11, F2

Biological processes related to Hypersplenism according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.9TLR4, FOXP3, GBA
2negative regulation of immune responseGO:0507779.7IL2RA, FOXP3
3positive regulation of interleukin-12 biosynthetic processGO:0450849.7REL, RELA, TLR4
4macrophage activationGO:0421169.7CSF2, TLR4
5cytokine productionGO:0018169.6FOXP3, CD4, REL
6negative regulation of inflammatory responseGO:0507289.5GBA, IL2RA, SERPINC1
7platelet activationGO:0301689.3ALB, THPO, F2, IL11, PIK3R1
8T cell receptor signaling pathwayGO:0508529.2RELA, CD4, PIK3R1, FOXP3
9blood coagulationGO:0075969.1ALB, SERPINC1, THPO, F2, PIK3R1
10cellular response to lipopolysaccharideGO:0712228.9TLR4, CSF2, CSF3, RELA
11cell surface receptor signaling pathwayGO:0071668.8CD4, IL2RA, IL7R, F2, EVL
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.7CSF3, CD4, IL11
13immune responseGO:0069558.3TLR4, CSF2, CSF3, CD4, IL2RA, IL7R
14positive regulation of cell proliferationGO:0082848.1CSF2, CSF3, EPO, RELA, IL11, F2
15positive regulation of transcription from RNA polymerase II promoterGO:0459447.9IL11, RELA, PIK3R1, FOXP3, CSF3, TLR4

Molecular functions related to Hypersplenism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7THPO, IL11, CSF3, CSF2
2growth factor activityGO:0080838.4THPO, F2, IL11, CSF3, CSF2
3protein bindingGO:0055155.7CD4, PIK3R1, FOXP3, CSF2, TLR4, EPO

Products for genes affiliated with Hypersplenism

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  • Antibodies
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Sources for Hypersplenism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet