MCID: HYP063
MIFTS: 50

Hypersplenism malady

Immune diseases, Blood diseases categories

Summaries for Hypersplenism

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Wikipedia:63 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards based summary: Hypersplenism, also known as hypersplenia, is related to portal hypertension and hepatitis. An important gene associated with Hypersplenism is THPO (thrombopoietin), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds anagrelide and mafosfamide have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone marrow, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Hypersplenism

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 38NCIt, 25ICD10
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Hypersplenism, Aliases & Descriptions:

Name: Hypersplenism 9 11 43 60
 
Hypersplenia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:6376
MeSH33 D006971
ICD9CM27 289.4
NCIt38 C34714
ICD1025 D73.1

Related Diseases for Hypersplenism

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Diseases related to Hypersplenism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension31.8EVL
2hepatitis31.1F2, THPO, ALB
3liver cirrhosis30.9F2, ALB, SERPINC1, THPO
4hepatitis c30.9THPO, F2, TLR4
5splenomegaly30.6IL2RA, EPO, THPO, GBA, CSF3
6portal vein thrombosis30.6THPO, SERPINC1, F2
7myelofibrosis30.5EPO, THPO
8arteriovenous fistula30.4EPO
9hepatocellular carcinoma30.4F2, PIK3R1, TLR4, FOXP3, ALB, CD4
10liver disease30.4ALB, THPO, SERPINC1, TLR4, F2
11purpura30.4THPO, SERPINC1
12acquired immunodeficiency syndrome30.4CD4, CSF2, ALB
13malaria30.3CD4, ALB
14felty's syndrome30.3CSF3, CSF2
15vascular disease30.2SERPINC1, CD4
16tuberculosis30.2ALB, CD4, TLR4, IL2RA
17hepatitis b30.1ALB, F2, TLR4, CD4
18polycythemia30.0EPO, THPO
19t-cell leukemia29.8CD4, FOXP3, RELA, IL2RA, REL
20stomatitis29.8CSF2, CSF3
21pancytopenia29.7THPO, GBA, EPO, IL2RA, CSF3, CSF2
22arthritis29.7ALB, CD4, CSF2, TLR4, FOXP3
23neutropenia29.6CSF3, CSF2, EPO, THPO
24acute leukemia29.6CSF3, EPO, THPO, CSF2
25thrombocytopenia29.2TLR4, CSF2, CD4, CSF3, ALB, EPO
26leukemia28.5IL7R, GBA, CSF3, CD4, PIK3R1, THPO
27capillary leak syndrome10.6CSF2
28thrombocytopenic purpura, autoimmune10.6THPO
29hydrops fetalis10.5GBA
30cryptosporidiosis10.5CD4
31sneddon syndrome10.5SERPINC1
32factor xii deficiency10.5SERPINC1
33cryptococcosis10.5CD4
34pyelonephritis10.4TLR4
35bernard-soulier syndrome, type c10.4F2, THPO
36dysfibrinogenemia10.4F2, SERPINC1
37hypoprothrombinemia10.4F2, SERPINC1
38macrocytic anemia, refractory, due to 5q deletion, somatic10.4EPO
39megakaryocytic leukemia10.4CSF2, THPO
40thrombophilia due to antithrombin iii deficiency10.4SERPINC1, F2
41protein s deficiency10.4SERPINC1, F2
42hemorrhagic disease10.4SERPINC1, F2
43factor vii deficiency10.4F2, SERPINC1
44placental abruption10.4F2, SERPINC1
45tropical spastic paraparesis10.4IL2RA, FOXP3
46autoimmune lymphoproliferative syndrome10.4IL2RA, CD4
47esophageal varix10.4ALB, F2
48histoplasmosis10.4RELA, REL
49hemophilia a10.4F2, SERPINC1
50thrombophilia due to activated protein c resistance10.3F2, SERPINC1

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to hypersplenism

Symptoms for Hypersplenism

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Drugs & Therapeutics for Hypersplenism

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Drug clinical trials:

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Genetic Tests for Hypersplenism

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Anatomical Context for Hypersplenism

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MalaCards organs/tissues related to Hypersplenism:

31
Spleen, Liver, Bone marrow, Bone, Myeloid, T cells, Testes, B cells, Pineal, Brain, Pancreas, Breast

Animal Models for Hypersplenism or affiliated genes

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Publications for Hypersplenism

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Articles related to Hypersplenism:

(show top 50)    (show all 434)
idTitleAuthorsYear
1
A novel method for laparoscopic splenectomy in the setting of hypersplenism secondary to liver cirrhosis: ten years' experience. (24867471)
2014
2
Opportunistic Fonsecaea pedrosoi brain abscess in a patient with non-cirrhotic portal fibrosis-induced hypersplenism--a novel association. (23458558)
2013
3
Prophylaxis against hepatitis B virus recurrence after liver transplantation for hepatitis B virus-related end-stage liver diseases with severe hypersplenism and splenomegaly: role of splenectomy. (22483806)
2012
4
Partial splenic embolization using Bletilla striata particles for hypersplenism in cirrhosis: a prospective study. (21476204)
2011
5
Total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism. (21734807)
2011
6
Partial splenic embolization as an alternative to splenectomy in hypersplenism--single center experience in 16 years. (20862632)
2010
7
Hypersplenism caused by an accessory spleen mimicking an intra-abdominal neoplasm: report of a case. (19779782)
2009
8
Portal hypertension and hypersplenism in a patient with a Bochdalek hernia: a case report. (18398560)
2009
9
Two-year follow-up of splenic radiofrequency ablation in patients with cirrhotic hypersplenism: does increased hepatic arterial flow induce liver regeneration? (18374048)
2008
10
Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. (19039645)
2008
11
Congenital absence of the portal vein with splenomegaly and hypersplenism in a young woman. (12743449)
2003
12
Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. (12753144)
2003
13
Acute hypersplenism with splenomegaly after portal vein embolization. (12075192)
2002
14
Interleukin-11 administration normalizes the platelet count in a hypersplenic cirrhotic patient. (12424546)
2002
15
The first experience with non-operative treatment of hypersplenism in children with portal hypertension. (12469254)
2002
16
Partial splenic embolization for hypersplenism before and after liver transplantation. (12372046)
2002
17
Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome. (11170921)
2001
18
Hypersplenism. (11338057)
2001
19
Locoregional intrasplenic chemotherapy for hypersplenism in myelofibrosis. (11552991)
2001
20
Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. (11139352)
2000
21
Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis. (8946990)
1996
22
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism...". (8855767)
1996
23
A long-term investigation of transcatheter splenic arterial embolization for hypersplenism. (8682485)
1996
24
Partial splenic embolisation and improvement of hypersplenism before liver transplantation. (7741576)
1995
25
Hypersplenism in liver cirrhosis: is conservative treatment still best? (8857456)
1995
26
Splenic ablation by percutaneous injection of ethanolamine oleate in dogs: a possible therapy for hypersplenism. (2606310)
1989
27
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
28
Hypersplenism secondary to a ruptured gallbladder and a pericholecystic abscess that presented as staphylococcal septicemia. (3949560)
1986
29
Computed tomography follow-up of nonsurgical treatment for hypersplenism. (3731807)
1986
30
Clinical disorders of splenic function: the spectrum from asplenism to hypersplenism. (6887967)
1983
31
Splenic embolization in a child with hypersplenism. (7161676)
1982
32
Partial splenic embolization in the management of hypersplenism secondary to Gaucher disease. (7131151)
1982
33
Isoniazid-related liver disease. Occurrence with portal hypertension, hypoalbuminemia, and hypersplenism. (448941)
1979
34
Splenectomy for hypersplenism. (707906)
1978
35
Control of hypersplenism and painful splenomegaly in myeloid metaplasia by irradiation. (413815)
1977
36
Hypersplenism in Hodgkin's disease: a report of three cases presenting with cytopenias. (593655)
1977
37
Experimental hypersplenism in mice. (131348)
1976
38
Partial splenectomy and pleural splenic transposition, a new approach to congestive hypersplenism of portal hypertension. (5037265)
1972
39
The kinetics of plaque-forming cells in experimental hypersplenism. (4999135)
1971
40
HYPERSPLENISM IN SICKLE CELL ANEMIA. (14170620)
1964
41
Hypersplenism. (13749081)
1961
42
Hypersplenism due to infection. A study of five cases manifesting hemolytic anemia. (13789380)
1961
43
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
44
Hypersplenism. (13230762)
1955
45
Secondary hypersplenism with recurrent gastrointestinal bleeding. (13059633)
1953
46
Surgical aspects of hypersplenism. (13036936)
1953
47
Hypersplenism. (14863408)
1951
48
The use of ACTH in hypersplenism. (14931201)
1951
49
Hypersplenism in a patient with lymphogranuloma benignum. (15391143)
1949
50
The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. (21013546)
1946

Variations for Hypersplenism

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Expression for genes affiliated with Hypersplenism

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Search GEO for disease gene expression data for Hypersplenism.

Pathways for genes affiliated with Hypersplenism

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Pathways related to Hypersplenism according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.6FOXP3, IL2RA, CSF2
2
Show member pathways
9.6FOXP3, IL2RA, CSF2
3
Show member pathways
9.5IL2RA, PIK3R1, CD4
4
Show member pathways
9.4IL2RA, F2, PIK3R1, THPO
59.4CSF2, CD4, CSF3
69.1RELA, IL2RA, IL7R
7
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.1PIK3R1, REL, RELA
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.1RELA, PIK3R1, REL
9
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.1RELA, PIK3R1, REL
109.1REL, PIK3R1, RELA
119.1REL, RELA, PIK3R1
12
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.1REL, RELA, PIK3R1
13
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.1REL, RELA, PIK3R1
14
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0TLR4, REL, RELA
159.0RELA, TLR4, REL
169.0PIK3R1, CSF2, RELA
17
Show member pathways
9.0RELA, IL2RA, PIK3R1
18
Show member pathways
8.9TLR4, CSF2, RELA
19
Show member pathways
thioredoxin pathway36
8.9F2, RELA, ALB
20
Show member pathways
8.9PIK3R1, TLR4, RELA
21
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.8CD4, RELA, REL, IL2RA
22
Show member pathways
8.8SERPINC1, THPO, PIK3R1, F2, ALB
23
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
8.8CD4, RELA, REL, PIK3R1
24
Show member pathways
8.8CD4, REL, RELA, PIK3R1
25
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.8PIK3R1, RELA, REL, CSF2
26
Show member pathways
Immune response IL 3 activation and signaling pathway58
8.8IL2RA, REL, PIK3R1, RELA
27
Show member pathways
IL2 signaling events mediated by STAT536
8.7IL2RA, FOXP3, RELA, PIK3R1
288.7PIK3R1, CSF2, IL2RA, RELA
29
Show member pathways
8.7TLR4, RELA, PIK3R1, FOXP3
308.6CSF2, TLR4, PIK3R1, RELA
31
Show member pathways
8.6TLR4, PIK3R1, IL2RA, RELA
32
Show member pathways
8.6PIK3R1, TLR4, IL2RA, RELA
33
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.6REL, F2, PIK3R1, CD4, RELA
34
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.5THPO, PIK3R1, RELA, IL7R, IL2RA
35
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.5CD4, CSF2, RELA, PIK3R1, REL
36
Show member pathways
8.5TLR4, REL, PIK3R1, THPO, RELA
378.4RELA, TLR4, PIK3R1, EPO
38
Show member pathways
8.4PIK3R1, IL2RA, IL7R, CSF2, RELA
39
Show member pathways
8.4RELA, PIK3R1, CSF2, IL7R, IL2RA
40
Show member pathways
8.4CD4, PIK3R1, EVL, RELA
41
Show member pathways
8.4F2, EPO, IL7R, CD4, IL2RA, THPO
42
Show member pathways
Type III interferon signaling36
8.3EPO, IL2RA, IL7R, CSF2, CSF3, PIK3R1
43
Show member pathways
8.2CD4, THPO, PIK3R1, CSF3, IL2RA, IL7R
44
Show member pathways
8.2IL2RA, IL7R, CD4, CSF3, CSF2, PIK3R1
45
Show member pathways
8.2EVL, RELA, REL, PIK3R1, CD4
468.1CD4, IL2RA, THPO, EPO, CSF2, IL7R
47
Show member pathways
7.9CSF3, RELA, TLR4, REL, FOXP3, CSF2
48
Show member pathways
7.8PIK3R1, THPO, TLR4, IL2RA, CSF3, CSF2
497.3CSF3, IL7R, PIK3R1, TLR4, EPO, RELA
50
Show member pathways
6.5CSF3, TLR4, F2, EPO, RELA, IL2RA

Compounds for genes affiliated with Hypersplenism

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Compounds related to Hypersplenism according to GeneCards Suite gene sharing:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1anagrelide43 1210.9THPO, CSF2, EPO
2mafosfamide439.8CSF3, THPO, CSF2
3hepaplastin439.7SERPINC1, ALB, F2
4tranexamic acid43 1210.7F2, EPO, SERPINC1
5phenprocoumon43 49 1211.7F2, SERPINC1, ALB
6pegfilgrastim43 1210.6CSF2, CSF3, EPO
7epsilon aminocaproic acid439.4SERPINC1, F2, EPO
8pixy321439.4CSF3, EPO, THPO, CSF2
9amifostine43 1210.4CSF3, EPO, THPO, CSF2
10filgrastim43 1210.4THPO, CSF2, CSF3, EPO
11gm-csf43 2810.4THPO, EPO, CSF2, CSF3
12anti-fungal439.4CSF3, CSF2, TLR4, REL
13methylcellulose439.4CSF3, CSF2, THPO, EPO
14polyethylene glycol439.4SERPINC1, F2, THPO, ALB
15chloroquine43 2 49 28 1213.3SERPINC1, TLR4, CD4, IL2RA
16hydroxyethyl starch439.3SERPINC1, CSF3, F2, ALB
17carboplatin43 49 1211.2EPO, CSF3, CSF2, THPO
18hydroxyurea43 49 1211.2CSF3, F2, CSF2, THPO, EPO
19bleomycin43 1210.2CSF2, EPO, IL2RA, CSF3
20etoposide43 49 59 1212.0PIK3R1, IL2RA, CSF2, CSF3, THPO
21mycophenolate mofetil43 49 1211.0ALB, CSF3, EPO, IL2RA
22aminoguanidine43 28 1211.0TLR4, EPO, ALB
23genistein43 28 59 2 24 1214.0PIK3R1, IL2RA, TLR4, CSF2, THPO, CD4
24pge2438.9CSF2, FOXP3, TLR4, SERPINC1, IL2RA, CD4
25fibrinogen438.9ALB, SERPINC1, TLR4, THPO, F2
26aspirin43 49 28 2411.8GBA, F2, THPO, TLR4, SERPINC1, IL2RA
27zidovudine43 49 1210.8CD4, ALB, CSF2, EPO, CSF3
28imatinib43 49 1210.8THPO, PIK3R1, EPO, CSF3, ALB
29polysaccharide438.7TLR4, THPO, SERPINC1, CSF2, GBA, IL2RA
30estrogen438.7CSF2, PIK3R1, IL2RA, F2, THPO, SERPINC1
31histamine43 28 2410.7THPO, TLR4, IL2RA, ALB, CSF2
32lactate438.7ALB, EPO, F2, TLR4, THPO, CSF2
33creatinine438.7F2, IL2RA, SERPINC1, EPO, ALB, THPO
34calcitriol43 59 24 1211.7CSF2, IL2RA, EPO, TLR4, F2, ALB
35rantes438.6CD4, CSF3, CSF2, REL, THPO, IL2RA
36vitamin d438.6ALB, TLR4, EPO, CSF2, IL2RA
37phospholipid438.6PIK3R1, IL2RA, TLR4, GBA, F2
38gp 130438.5CSF3, CSF2, IL7R, PIK3R1, THPO, EPO
39aspartate438.5EPO, ALB, IL2RA, TLR4, PIK3R1, F2
40thymidine43 249.5PIK3R1, GBA, IL2RA, CSF2, EPO, CSF3
41heparin43 28 24 1211.4THPO, CSF2, IL7R, IL2RA, SERPINC1, F2
42cysteine438.3CSF2, ALB, CD4, IL2RA, REL, TLR4
43phosphatidylinositol438.3CD4, CSF2, IL7R, IL2RA, EPO, THPO
44cyclosporin a43 28 5910.2F2, REL, FOXP3, IL2RA, CSF2, CSF3
45methotrexate49 43 1210.2F2, TLR4, EPO, IL2RA, ALB, CSF3
46dexamethasone43 49 28 1211.2CSF2, REL, CSF3, SERPINC1, IL2RA, TLR4
47vegf438.0THPO, PIK3R1, CSF3, TLR4, SERPINC1, EPO
48testosterone43 59 24 1210.7EPO, IL2RA, ALB, PIK3R1, SERPINC1, RELA
49serine437.7PIK3R1, RELA, F2, GBA, CD4, REL
50tyrosine437.6EPO, REL, IL2RA, IL7R, CSF2, CD4

GO Terms for genes affiliated with Hypersplenism

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Cellular components related to Hypersplenism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.4ALB, SERPINC1, F2
2external side of plasma membraneGO:00098979.1CD4, IL7R, IL2RA, TLR4
3extracellular regionGO:00055768.0ALB, F2, SERPINC1, EPO, IL7R, CSF2
4extracellular spaceGO:00056157.9SERPINC1, EPO, CSF2, CSF3, ALB, F2

Biological processes related to Hypersplenism according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immune responseGO:005077710.1IL2RA, FOXP3
2cytokine productionGO:000181610.0REL, FOXP3, CD4
3macrophage activationGO:004211610.0CSF2, TLR4
4negative regulation of neuron deathGO:019012159.9CSF3, REL
5negative regulation of interleukin-6 productionGO:00327159.9GBA, FOXP3, TLR4
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9CSF2, EPO
7negative regulation of osteoclast differentiationGO:00456719.8PIK3R1, TLR4
8negative regulation of interferon-gamma productionGO:00326899.8TLR4, FOXP3
9negative regulation of inflammatory responseGO:00507289.8IL2RA, GBA, SERPINC1
10defense response to Gram-negative bacteriumGO:00508299.7TLR4, CD4
11response to testosteroneGO:00335749.5GBA, EPO
12platelet activationGO:00301689.4ALB, THPO, PIK3R1, F2
13positive regulation of interleukin-12 biosynthetic processGO:00450849.4TLR4, REL, RELA
14cell surface receptor signaling pathwayGO:00071669.1CD4, F2, IL2RA, IL7R, EVL
15T cell receptor signaling pathwayGO:00508529.1CD4, PIK3R1, RELA, FOXP3
16blood coagulationGO:00075969.1PIK3R1, ALB, F2, SERPINC1, THPO
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.1RELA, REL, TLR4
18cellular response to lipopolysaccharideGO:00712228.7CSF2, RELA, TLR4, CSF3
19immune responseGO:00069558.7CSF2, TLR4, CD4, CSF3, IL2RA, IL7R
20positive regulation of transcription, DNA-templatedGO:00458938.7FOXP3, REL, RELA, EPO
21positive regulation of cell proliferationGO:00082848.4F2, EPO, RELA, CSF2, CSF3
22positive regulation of transcription from RNA polymerase II promoterGO:00459448.3TLR4, RELA, FOXP3, CSF3, PIK3R1

Molecular functions related to Hypersplenism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1NF-kappaB bindingGO:00510599.4FOXP3, RELA
2cytokine activityGO:00051259.1CSF3, THPO, CSF2
3growth factor activityGO:00080839.1CSF2, THPO, F2, CSF3
4protein bindingGO:00055155.1EPO, GBA, F2, PIK3R1, TLR4, SERPINC1

Products for genes affiliated with Hypersplenism

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Sources for Hypersplenism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
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50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
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