MCID: HYP063
MIFTS: 47

Hypersplenism

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Hypersplenism

MalaCards integrated aliases for Hypersplenism:

Name: Hypersplenism 12 52 42 14 69
Hypersplenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6376
ICD10 33 D73.1
ICD9CM 35 289.4
MeSH 42 D006971
NCIt 47 C34714
UMLS 69 C0020532

Summaries for Hypersplenism

MalaCards based summary : Hypersplenism, also known as hypersplenia, is related to lymphoma and malaria, and has symptoms including hepatosplenomegaly An important gene associated with Hypersplenism is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Aspirin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

Related Diseases for Hypersplenism

Diseases related to Hypersplenism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.2 ALB FOXP3 IFNG IL4
2 malaria 27.9 ALB EPO FOXP3 IFNG IL4
3 splenomegaly 11.2
4 nodular regenerative hyperplasia 10.8
5 non-hodgkin lymphoma, during pregnancy 10.8 ALB F2
6 oral cavity carcinoma in situ 10.7 ALB F2
7 female infertility of uterine origin 10.7 ALB F2
8 pancreatic cystadenocarcinoma 10.7 ALB F2
9 duane retraction syndrome 10.7 ALB F2
10 atrophic vulva 10.7 ALB F2
11 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.7 ALB IFNG
12 cerebral sarcoidosis 10.6 ALB EPO
13 syncope 10.6 F2 SERPINC1
14 cataract 10.6 ALB SERPINC1
15 pyridoxine deficiency anemia 10.6 F2 SERPINC1
16 superior limbic keratoconjunctivitis 10.6 F2 SERPINC1
17 von economo's disease 10.6 FOXP3 IFNG
18 tonsil cancer 10.6 ALB IFNG
19 follicular adenoma 10.6 F2 SERPINC1
20 myiasis 10.6 F2 SERPINC1
21 polyarteritis nodosa 10.6 ALB IFNG
22 testicular gonadoblastoma 10.6 F2 SERPINC1
23 egg allergy 10.6 F2 SERPINC1
24 rectum neuroendocrine neoplasm 10.6 F2 SERPINC1
25 syndactyly, mesoaxial synostotic, with phalangeal reduction 10.6 F2 SERPINC1
26 conjunctival vascular disease 10.6 ALB EPO
27 midline cystocele 10.6 F2 SERPINC1
28 collagenous colitis 10.6 F2 SERPINC1
29 littre gland carcinoma 10.5 F2 SERPINC1
30 kohler's disease 10.5 ALB F2
31 hiv-1 10.5 F2 SERPINC1
32 acute necrotizing encephalitis 10.5 ALB IFNG
33 glutathioninuria 10.5 F2 SERPINC1
34 pilomyxoid astrocytoma 10.5 F2 SERPINC1
35 inferolateral myocardial infarct 10.5 F2 SERPINC1
36 lymphatic system cancer 10.5 F2 SERPINC1
37 rheumatoid lung disease 10.5 F2 SERPINC1
38 rete ovarii adenoma 10.5 ALB F2
39 lethal congenital contracture syndrome 10.5 F2 SERPINC1
40 lujo hemorrhagic fever 10.5 F2 SERPINC1
41 cryptosporidiosis 10.5 F2 SERPINC1
42 essential thrombocythemia 10.5 F2 SERPINC1
43 myopia 10.5 ALB F2
44 poems syndrome 10.5 EPO THPO
45 spinal cord lipoma 10.5 F2 SERPINC1
46 intestinal pseudo-obstruction 10.5 F2 SERPINC1
47 articulation disorder 10.4 ALB EPO
48 microcephaly 8, primary, autosomal recessive 10.4 ALB EPO F2
49 mediastinum leiomyoma 10.4 ALB EPO F2
50 congenital syphilis 10.4 F2 SERPINC1

Comorbidity relations with Hypersplenism via Phenotypic Disease Network (PDN): (show all 12)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Alcoholic Liver Cirrhosis
Chronic Congestive Splenomegaly Deficiency Anemia
Heart Disease Hepatic Encephalopathy
Iron Deficiency Anemia Neutropenia
Portal Hypertension Primary Thrombocytopenia

Graphical network of the top 20 diseases related to Hypersplenism:



Diseases related to Hypersplenism

Symptoms & Phenotypes for Hypersplenism

UMLS symptoms related to Hypersplenism:


hepatosplenomegaly

MGI Mouse Phenotypes related to Hypersplenism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 EPO F2 FOXP3 IFNG IL4 IL7R
2 homeostasis/metabolism MP:0005376 10.02 ALB EPO F2 FOXP3 IFNG IL4
3 immune system MP:0005387 9.97 EPO F2 FOXP3 IFNG IL4 IL7R
4 liver/biliary system MP:0005370 9.8 PIK3R1 SERPINC1 ALB EPO FOXP3 IFNG
5 mortality/aging MP:0010768 9.76 ALB EPO F2 FOXP3 IFNG IL4
6 normal MP:0002873 9.56 ALB EPO F2 FOXP3 IFNG IL4
7 renal/urinary system MP:0005367 9.02 ALB FOXP3 IFNG IL4 SERPINC1

Drugs & Therapeutics for Hypersplenism

Drugs for Hypersplenism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
3
Dalteparin Approved Phase 4 9005-49-6
4
Dipyridamole Approved Phase 4 58-32-2 3108
5
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
6 Nadroparin Approved Phase 4 9041-08-1
7
Warfarin Approved Phase 4 81-81-2 6691 54678486
8
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
9 tannic acid Approved, Nutraceutical Phase 4
10 Liver Extracts Phase 4,Phase 2,Phase 3
11 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
12 Analgesics Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Anticoagulants Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Antipyretics Phase 4
18 Antirheumatic Agents Phase 4
19 calcium heparin Phase 4
20 Calcium, Dietary Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Fibrinolytic Agents Phase 4
23 Heparin, Low-Molecular-Weight Phase 4
24 Peripheral Nervous System Agents Phase 4
25 Phosphodiesterase Inhibitors Phase 4
26 Platelet Aggregation Inhibitors Phase 4
27 Vasodilator Agents Phase 4
28 Adrenergic Agents Phase 4
29 Adrenergic alpha-1 Receptor Antagonists Phase 4
30 Adrenergic alpha-Antagonists Phase 4
31 Adrenergic Antagonists Phase 4
32 Adrenergic beta-Antagonists Phase 4
33 Antihypertensive Agents Phase 4
34
Valproic Acid Approved, Investigational Phase 1, Phase 2 99-66-1 3121
35
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
36
Tegafur Approved Phase 2 17902-23-7 5386
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
38
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
39
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
40 Anticonvulsants Phase 1, Phase 2
41 Antimanic Agents Phase 1, Phase 2
42 Central Nervous System Depressants Phase 1, Phase 2
43 GABA Agents Phase 1, Phase 2
44 Psychotropic Drugs Phase 1, Phase 2
45 Tranquilizing Agents Phase 1, Phase 2
46 Antimetabolites Phase 2
47 Antimetabolites, Antineoplastic Phase 2
48 Micronutrients Phase 2
49 Nicotinic Acids Phase 2
50 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:

(show all 12)

id Name Status NCT ID Phase Drugs
1 Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy Recruiting NCT02238444 Phase 4 Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
2 Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS Recruiting NCT02925975 Phase 4 Carvedilol
3 ABMSC Infusion Through Hepatic Artery in Portal Hypertension Surgery for the Treatment of Liver Cirrhosis Unknown status NCT01560845 Phase 2, Phase 3
4 Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Completed NCT00605657 Phase 1, Phase 2 Valproic Acid
5 Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACE Terminated NCT01539018 Phase 2 Sorafenib;sorafenib plus tegafur-uracil
6 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584
7 Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis Unknown status NCT01201655
8 Treatment of Portal Vein Tumor Thrombus After Hepatocellular Carcinoma Resection Completed NCT00825669 TACE
9 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
10 The Treatment of Hepatocirrhosis and Portal Hypertension Recruiting NCT02778425
11 The Natural History and Prognostic Factors of Compensated Cirrhosis. Recruiting NCT03144700
12 Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension Not yet recruiting NCT03269877

Search NIH Clinical Center for Hypersplenism

Cochrane evidence based reviews: hypersplenism

Genetic Tests for Hypersplenism

Anatomical Context for Hypersplenism

MalaCards organs/tissues related to Hypersplenism:

39
Spleen, Liver, Bone, Bone Marrow, T Cells, Myeloid, Testes

Publications for Hypersplenism

Articles related to Hypersplenism:

(show top 50) (show all 486)
id Title Authors Year
1
Klippel-Trenaunay-Weber syndrome with atypical presentation of hypersplenism and nephrotic syndrome: a case report. ( 28823249 )
2017
2
JOURNAL CLUB: Four-Dimensional Flow MRI-Based Splenic Flow Index for Predicting Cirrhosis-Associated Hypersplenism. ( 28463524 )
2017
3
Microwave ablation in the spleen versus partial splenic artery embolisation: A new technique for hypersplenism in cirrhosis. ( 28256406 )
2017
4
Postoperative Prognostic Nutritional Index Predicts Survival of Patients with Hepatocellular Carcinoma within Milan Criteria and Hypersplenism. ( 28523484 )
2017
5
Successful Treatment of Hypersplenism in Wilson's Disease by Partial Splenic Embolization. ( 28135891 )
2017
6
Partial Splenic Artery Embolization to Treat Hypersplenism Secondary to Hepatic Cirrhosis: A Meta-Analysis. ( 28316312 )
2017
7
Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism. ( 27393102 )
2016
8
Treatment of Hypersplenism by Partial Splenic Embolization Through Gastric Collaterals. ( 27200164 )
2016
9
Laparoscopic splenic artery ligation for hypersplenism in cirrhosis: A case series. ( 27251809 )
2016
10
Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension. ( 27006743 )
2016
11
Laparoscopic Splenectomy for the Elderly Liver Cirrhotic Patients With Hypersplenism: A Retrospective Comparable Study. ( 26962816 )
2016
12
Pancreatic fistula after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis: effect of fibrin glue and polyglycolic acid felt on prophylaxis of postoperative complications. ( 27162072 )
2016
13
Hypersplenism: History and current status. ( 27703501 )
2016
14
Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process. ( 26865982 )
2016
15
Hepatocellular Carcinoma with Hypersplenic Thrombocytopenia and Situs Inversus Totalis: A Case Report. ( 28031104 )
2016
16
Risk Factors for Portal Vein System Thrombosis After Laparoscopic Splenectomy in Cirrhotic Patients with Hypersplenism. ( 26953863 )
2016
17
Partial Splenic Embolization in a Child with Sickle Cell Disease and Hypersplenism. ( 27926404 )
2016
18
A Comparative Study of Surgical Splenectomy, Partial Splenic Embolization, and High-Intensity Focused Ultrasound for Hypersplenism. ( 26839374 )
2016
19
Dameshek W, Miller EB. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. 1946. ( 26744432 )
2016
20
Hypersplenism Associated With Late-Presenting Congenital Diaphragmatic Hernia: A Rare Combination. Case Report. ( 27227931 )
2016
21
Simultaneous microwave coagulo-necrotic therapy (MCN) and laparoscopic splenectomy for the treatment of hepatocellular carcinoma with cirrhotic hypersplenism. ( 27577937 )
2016
22
Hypersplenism is correlated with increased risk of hepatocellular carcinoma in patients with post-hepatitis cirrhosis. ( 26753954 )
2016
23
Severe hypersplenism associated to hemophagocytic and lymphoproliferative syndrome secondary to Epstein-Barr virus infection. A report of two cases. ( 27041246 )
2016
24
Influence of lactulose on interventional therapy for HCC patients with hepatocirrhosis and hypersplenism. ( 26919955 )
2016
25
Laparoscopic versus traditional open splenectomy for hepatocellular carcinoma with hypersplenism. ( 27465326 )
2016
26
Simultaneous hepatectomy and splenectomy versus hepatectomy alone for hepatocellular carcinoma complicated by hypersplenism: a meta-analysis. ( 26316782 )
2015
27
Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option. ( 26034376 )
2015
28
Laparoscopic surgery is more advantageous than laparotomic surgery for treatment of hypersplenism with gallstones. ( 26091138 )
2015
29
Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study. ( 25741142 )
2015
30
Hypersplenism Treated by Partial Splenic Embolization Using Guglielmi Detachable Coils. ( 26328643 )
2015
31
Isolated Splenic Vein Thrombosis: 8-Year-Old Boy with Massive Upper Gastrointestinal Bleeding and Hypersplenism. ( 26345989 )
2015
32
Percutaneous transhepatic embolization of gastroesophageal varices combined with partial splenic embolization for the treatment of variceal bleeding and hypersplenism. ( 26770628 )
2015
33
Splenectomy attenuates murine liver fibrosis with hypersplenism stimulating hepatic accumulation of Ly-6C(lo) macrophages. ( 26022691 )
2015
34
Hypersplenism: an independent risk factor for myocardial remodeling in chronic heart failure patients. ( 26131093 )
2015
35
Partial embolization as re-treatment of hypersplenism after unsuccessful splenic artery ligation. ( 25632215 )
2015
36
Portal and splanchnic hemodynamics after partialA splenic embolization in cirrhotic patients with hypersplenism. ( 26547369 )
2015
37
Splenectomy Followed by Hepatectomy for Hepatocellular Carcinoma with Hypersplenism and Portal Hypertension Caused by Macroglobulinemia. ( 26124358 )
2015
38
Anaesthetic management of beta thalassemia major with hypersplenism for splenectomy in pediatric age group: Report of four cases. ( 26417142 )
2015
39
Microwave Ablation for the Treatment of Hypersplenism: Short Waves, Low Cost, Big Results. ( 26541991 )
2015
40
Partial Splenic Artery Embolization for the Management of Hypersplenism in Cirrhosis. ( 26388645 )
2015
41
Comparison of two laparoscopic splenectomy plus pericardial devascularization techniques for management of portal hypertension and hypersplenism. ( 25783835 )
2015
42
An innovative modification of sandwich embolization technique for simultaneous management of ruptured pseudoaneurysm of branch of splenic artery and hypersplenism syndrome. ( 25900542 )
2015
43
Laparoscopic splenic vessels ligation as a treatment of hypersplenism and thrombocytopenia in children. ( 26659241 )
2015
44
Thrombocytopenia due to hypersplenism in oncological disease: Partial splenic embolization during palliative treatment. ( 25737395 )
2015
45
Can hypersplenism secondary to portal hypertension be treated by non-selective beta blockers? ( 25788189 )
2015
46
Percutaneous Microwave Ablation in the Spleen for Treatment of Hypersplenism in Cirrhosis Patients. ( 26031423 )
2015
47
Partial splenic embolization of patients with hypersplenism by transradial or transfemoral approach: a prospective randomized controlled trial. ( 26671306 )
2015
48
Successful Splenectomy for Hypersplenism in Wilson's Disease: A Single Center Experience from China. ( 25910248 )
2015
49
Utility of Partial Splenic Embolization for Hypersplenism using Guglielmi Detachable Coils. ( 26897954 )
2015
50
Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria. ( 24673826 )
2014

Variations for Hypersplenism

Expression for Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

Pathways for Hypersplenism

Pathways related to Hypersplenism according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.31 EPO F2 IFNG IL4 IL7R PIK3R1
2
Show member pathways
13.15 EPO F2 IFNG IL4 IL7R PIK3R1
3
Show member pathways
13.04 ALB F2 PIK3R1 SERPINC1 THPO
4
Show member pathways
12.5 IL4 IL7R PIK3R1 THPO
5 11.67 EPO IFNG PIK3R1
6 11.56 IFNG IL4 IL7R
7
Show member pathways
11.51 FOXP3 IFNG IL4
8 11.5 EPO IFNG IL7R PIK3R1
9 11.44 EPO IL4 IL7R THPO
10 11.42 EPO IFNG IL4 IL7R THPO
11
Show member pathways
11.41 FOXP3 IL4 PIK3R1
12
Show member pathways
11.34 EPO IFNG IL4 IL7R PIK3R1 THPO
13 11.17 FOXP3 IFNG IL4
14 11.11 IFNG IL4
15 11.09 IFNG IL4
16 11.05 IFNG IL4
17 11 IL7R PIK3R1
18 10.96 IFNG IL4
19 10.93 F2 IFNG
20 10.87 IFNG PIK3R1

GO Terms for Hypersplenism

Cellular components related to Hypersplenism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB EPO F2 IFNG IL4 SERPINC1
2 external side of plasma membrane GO:0009897 9.46 F2 IFNG IL4 IL7R
3 blood microparticle GO:0072562 9.43 ALB F2 SERPINC1
4 extracellular region GO:0005576 9.23 ALB EPO F2 IFNG IL4 IL7R

Biological processes related to Hypersplenism according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 EPO FOXP3 IFNG IL4
2 positive regulation of cell proliferation GO:0008284 9.85 EPO F2 IFNG IL4
3 negative regulation of apoptotic process GO:0043066 9.84 ALB EPO IL4 PIK3R1
4 cellular protein metabolic process GO:0044267 9.76 ALB F2 SERPINC1
5 T cell receptor signaling pathway GO:0050852 9.65 FOXP3 IFNG PIK3R1
6 positive regulation of establishment of protein localization to plasma membrane GO:0090004 9.57 IFNG PIK3R1
7 positive regulation of activated T cell proliferation GO:0042104 9.56 EPO IL4
8 regulation of blood coagulation GO:0030193 9.52 F2 SERPINC1
9 negative regulation of osteoclast differentiation GO:0045671 9.51 IL4 PIK3R1
10 response to nutrient GO:0007584 9.5 EPO IL4 SERPINC1
11 defense response to protozoan GO:0042832 9.49 IFNG IL4
12 negative regulation of interleukin-17 production GO:0032700 9.46 FOXP3 IFNG
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IFNG IL4
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 EPO IFNG IL4
15 positive regulation of chemokine biosynthetic process GO:0045080 9.4 IFNG IL4
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IFNG IL4
17 negative regulation of T-helper 17 cell differentiation GO:2000320 9.16 FOXP3 IL4
18 negative regulation of chronic inflammatory response GO:0002677 8.96 FOXP3 IL4
19 positive regulation of protein phosphorylation GO:0001934 8.92 F2 IFNG IL4 THPO

Molecular functions related to Hypersplenism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IFNG IL4 THPO
2 growth factor activity GO:0008083 8.8 F2 IL4 THPO

Sources for Hypersplenism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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