HTN
MCID: HYP075
MIFTS: 86

Hypertension (HTN) malady

Cardiovascular diseases, Blood diseases categories

Summaries for Hypertension

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33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Blood pressure is the force of your blood pushing against the walls of your arteries. each time your heart beats, it pumps blood into the arteries. your blood pressure is highest when your heart beats, pumping the blood. this is called systolic pressure. when your heart is at rest, between beats, your blood pressure falls. this is called diastolic pressure. your blood pressure reading uses these two numbers. usually the systolic number comes before or above the diastolic number. a reading of 119/79 or lower is normal blood pressure 140/90 or higher is high blood pressure between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. high blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. you can control high blood pressure through healthy lifestyle habits and taking medicines, if needed. nih: national heart, lung, and blood institute

MalaCards: Hypertension, also known as high blood pressure, is related to essential hypertension and portal hypertension. An important gene associated with Hypertension is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Insulin Processing. The drugs diltiazem and felodipine and the compounds sodium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

CDC:3 High blood pressure is a common and dangerous condition. Having high blood pressure means the pressure of the blood in your blood vessels is higher than it should be. But you can take steps to control your blood pressure and lower your risk.

Wikipedia:63 Hypertension (HTN) or high blood pressure, sometimes called arterial hypertension, is a chronic medical... more...

Description from OMIM:46 145500

Aliases & Classifications for Hypertension

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8Disease Ontology, 46OMIM, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


Aliases & Descriptions:

hypertension 8 46 10
high blood pressure 8 33
vascular hypertensive disorder 8
hypertensive disease 60
hyperpiesia 8
htn 8


Related Diseases for Hypertension

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension Malignant Hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1132)
idRelated DiseaseScoreTop Affiliating Genes
1essential hypertension31.9AGT, GNB3
2portal hypertension31.6NOS3
3primary pulmonary hypertension31.5SLC6A4, BMPR2
4hypertensive heart disease31.4NR3C2, ACE
5glaucoma31.3HSD11B2, BMPR2
6obesity31.3SGK1, COMT, HSD11B2, GNB3, NPR3, NR3C2
7diabetes mellitus31.2GNB3, NR3C2, AGT, NOS3, ACE, SGK1
8nephrosclerosis31.0ACE, NR3C2
9atherosclerosis31.0GNB3, AGT, CMA1, ACE, COMT, NOS3
10pre-eclampsia30.9NOS3, NOS2, EDN2, AGT, HSD11B2, NR3C2
11proteinuria30.9NR3C2, HSD11B2, GNB3, AGT, NOS3, ACE
12vascular disease30.9NOS2
13hyperaldosteronism30.8HSD11B2, NR3C2, ACE
14type 2 diabetes mellitus30.8GNB3, ACE, SGK1, NOS3, AGT
15liver cirrhosis30.8HSD11B2, AGT, NOS3
16myocardial infarction30.7COMT, NR3C2, SLC6A4, ACE2, ACE, NOS3
17diabetic nephropathy30.7ACE2, ACE, NOS3, AGT, NR3C2, HSD11B2
18coronary artery disease30.7NOS3, GNB3, AGT, ACE
19ischemia30.7NOS2, NOS3, NR3C2, SGK1, AGT
20hepatopulmonary syndrome30.7NOS3
21hypokalemia30.6NR3C2, ACE, HSD11B2
22adenoma30.6GNB3, HSD11B2, BMPR2, NR3C2
23glomerulonephritis30.5NOS2
24congestive heart failure30.5SGK1, ACE, NPR3, NR3C2, AGT
25ischemic heart disease30.4ACE, NOS2, NOS3, AGT
26cushing's syndrome30.4NR3C2, HSD11B2
27sickle cell disease30.3NOS3
28sarcoidosis30.3ACE
29cerebrovascular disease30.3ACE
30liddle syndrome30.3NEDD4L
31acute myocardial infarction30.3NR3C2, AGT, ACE, SLC6A4
32nephrotic syndrome30.3AGT, ACE
33uremia30.3NOS2, NOS3
34dementia30.3COMT
35diabetic retinopathy30.2AGT, NOS3, NOS2, ACE
36migraine30.2SLC6A4, COMT
37intracranial aneurysm30.2ACE2, NOS3
38hyperglycemia30.2ACE, HSD11B2, AGT, NOS2, NOS3, SGK1
39polycystic ovary syndrome30.2NR3C2
40dilated cardiomyopathy30.2ACE
41peritonitis30.1CMA1
42pseudohypoaldosteronism30.1NR3C2, SGK1
43anuria30.1ACE
44chronic kidney failure30.0HSD11B2, ACE, NOS3, AGT, NR3C2, EDN2
45congenital heart defect30.0CMA1, AGT, ACE, NR3C2, NOS3
46breast cancer29.9SGK1, HSD11B2, AGT, NR3C2, COMT, BMPR2
47asthma29.9NOS2, HSD11B2, CMA1
48apparent mineralocorticoid excess syndrome29.9NR3C2, HSD11B2
49colorectal cancer29.9COMT
50prostate cancer29.8NOS3, COMT, BMPR2, NR3C2

Graphical network of the top 20 diseases related to Hypertension:



Diseases related to hypertension

Clinical Features for Hypertension

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46OMIM
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Clinical features from OMIM:

145500

Drugs & Therapeutics for Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypertension

Drug clinical trials:

Search ClinicalTrials for Hypertension

Search NIH Clinical Center for Hypertension

Search CenterWatch for Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypertension

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Anatomical Context for Hypertension

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32MalaCards
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MalaCards organs/tissues related to Hypertension:

32
Heart, Endothelial, Kidney, Brain, Liver, Lung, Testes, Smooth muscle, Bone, Monocytes, Eye, Placenta, Spleen, Thyroid, Skeletal muscle, Skin, Retina, Prostate, Ovary, Spinal cord, Colon, Pancreas, Adrenal gland, T cells, Medulla oblongata, Cortex, Breast, Pituitary, Hypothalamus, Myeloid, Bone marrow, Adrenal cortex, Lymph node, Pons, B cells, Whole blood, Small intestine, Thymus, Cardiac myocytes, Cerebellum, Cervix, Thalamus, Prefrontal cortex, Adipocyte, Tongue

Animal Models for Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537613.2NEDD4L, BMPR2, NPR3, HSD11B2, COMT, NR3C2
2MP:000538513.1NEDD4L, BMPR2, NPR3, HSD11B2, COMT, NR3C2
3MP:001076812.9NEDD4L, BMPR2, NPR3, GNB3, HSD11B2, NR3C2
4MP:000536712.9SGK1, COMT, HSD11B2, NPR3, NEDD4L, NR3C2
5MP:000538612.4COMT, HSD11B2, NPR3, NEDD4L, NR3C2, AGT
6MP:000536912.4HSD11B2, BMPR2, NEDD4L, NR3C2, AGT, SLC6A4
7MP:000538712.0COMT, NPR3, BMPR2, NEDD4L, AGT, CMA1
8MP:000537511.5ACE, NOS2, NOS3, AGT, NPR3

Publications for Hypertension

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50PubMed
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Articles related to Hypertension:

(show top 50)    (show all 15549)
idTitleAuthorsYear
1
Effects of portal hypertension on contractility of rat spleen. (24140433)
2013
2
Nebivolol: a multifaceted antioxidant and cardioprotectant in hypertensive heart disease. (23921314)
2013
3
Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. (24327566)
2013
4
Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension. (22275815)
2012
5
Polymorphisms in the 3'UTR of the human leptin gene and their role in hypertension. (22218754)
2012
6
Association between cardiac function and pulmonary function in hypertensive patients. (22429350)
2012
7
Effectiveness of diode laser trans-scleral cyclophotocoagulation in patients following silicone oil-induced ocular hypertension in Chinese eyes. (21157080)
2011
8
Association of intergenic polymorphism of organic anion transporter 1 and 3 genes with hypertension and blood pressure response to hydrochlorothiazide. (21164499)
2011
9
Takayasu's arteritis mimicking unilateral pulmonary artery agenesis in a child with severe pulmonary hypertension and right heart failure: a diagnostic dilemma. (21674131)
2011
10
Didanosine Exposure and Noncirrhotic Portal Hypertension in a HIV Clinic in North America: a Follow-up Study. (22268001)
2011
11
Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension. (20204736)
2010
12
Elevated VEGF-plasma levels in young patients with mild essential hypertension. (19067736)
2009
13
Long-term effectiveness of lumboperitoneal flow-regulated shunt system for idiopathic intracranial hypertension. (20075822)
2009
14
Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives. (18773126)
2008
15
Predisease biological markers: early diagnosis and prevention of arterial hypertension. (18803964)
2008
16
Learning effect of humphrey matrix frequency doubling technology perimetry in patients with ocular hypertension. (18794676)
2008
17
Diagnosis and treatment of myocardial fibrosis in hypertensive heart disease. (18772529)
2008
18
Disturbed circadian blood pressure rhythm and C-reactive protein in essential hypertension. (18385743)
2008
19
Phaeochromocytoma and mixed corticomedullary tumour - a rare cause of Cushing's syndrome and labile hypertension in a primigravid woman postpartum. (17868399)
2008
20
Effect of fosinopril on progression of the asymptomatic carotid atherosclerosis and left ventricular hypertrophy in hypertensive patients]. (16915750)
2006
21
Hypertension is the most common component of metabolic syndrome and the greatest contributor to carotid arteriosclerosis in apparently healthy Japanese individuals. (15969252)
2005
22
No association of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia. (15751274)
2005
23
Impaired L-arginine transport and endothelial function in hypertensive and genetically predisposed normotensive subjects. (15569830)
2004
24
Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension: a 1-year follow-up study. (15486408)
2004
25
Genetic determinants of nonmodulating hypertension. (14530292)
2003
26
Epithelial sodium channel, salt intake, and hypertension. (12530930)
2003
27
Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. (14583445)
2003
28
Clinical study on long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol infusion]. (12783707)
2003
29
Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension. (11910312)
2002
30
Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review. (12038776)
2002
31
Effect of sympathetic and plasma renin activity on hemodialysis hypertension. (11269674)
2001
32
Genetics of primary pulmonary hypertension. (11590842)
2001
33
Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease. (11569573)
2001
34
Effect of chronic infusion of epoprostenol on echocardiographic right ventricular myocardial performance index and its relation to clinical outcome in patients with primary pulmonary hypertension. (11704014)
2001
35
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF- beta family. (11015450)
2000
36
High prevalence of undiagnosed primary hyperaldosteronism among patients with essential hypertension]. (10668287)
1999
37
Primary pulmonary hypertension: new reasons for optimism? (9577438)
1998
38
Treatable intracranial hypertension in patients with lupus nephritis. (9302663)
1997
39
Comparison of the serum insulin and endothelin level in patients with essential and renovascular hypertension. (9468006)
1997
40
Benign intracranial hypertension: a non-thrombotic complication of the primary antiphospholipid syndrome? (8528233)
1995
41
Skeletal muscle is a primary site of insulin resistance in essential hypertension. (1961128)
1991
42
Effect of thromboxane A2 synthetase inhibitor and prostacyclin analogue on arterial blood pressure, fibrinolysis and platelet function in patients with hypertension]. (1726988)
1991
43
Prevention of nephrosclerosis and cardiac hypertrophy by captopril treatment of spontaneously hypertensive rats. (2941600)
1986
44
Experimentally induced malignant hypertension in beagle dogs. (3764316)
1986
45
Elevated arterial cyclic AMP levels during the onset of renal hypertension in rats. (6295692)
1983
46
10. Hypertension. A comparison of the effects of angiotensin II infusion and variations in salt intake on plasma aldosterone levels in normal subjects, patients with essential hypertension and patients with hyperaldosteronism. (6310234)
1983
47
Use of captopril in the diagnosis of renal hypertension. (7030291)
1981
48
Autoregulation of cerebral blood flow during early experimental renal hypertension in the conscious dog. (623273)
1978
49
Salt, frusemide and renin in severe experimental renal hypertension. (1071587)
1976
50
Influence of adrenalectomy on radiation hypertension and nephrosclerosis. (1110974)
1975

Genetic Variations for Hypertension

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Expression for genes affiliated with Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertension

Search GEO for disease gene expression data for Hypertension.

Pathways for genes affiliated with Hypertension

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Hypertension

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1sodium44 2413.9HSD11B2, GNB3, NPR3, NEDD4L, NR3C2, AGT
2nitric oxide44 11 2414.9ACE, GNB3, ACE2, NPR3, BMPR2, EDN2
3cysteine4412.9NEDD4L, CMA1, SLC6A4, GRK4, AGT, COMT
4serine4412.9AGT, BMPR2, EDN2, GRK4, CMA1, SLC6A4
5calcium44 49 11 2415.8SGK1, EDN2, HSD11B2, NR3C2, AGT, CMA1
6arginine4412.7NOS2, NPR3, BMPR2, NR3C2, AGT, SLC6A4
7potassium44 11 2414.5GNB3, SGK1, ACE, AGT, EDN2, BMPR2
8glutamate4412.5GRK4, COMT, NEDD4L, NR3C2, SLC6A4, NOS3
9oxygen44 2413.5HSD11B2, ACE2, NOS2, NOS3, BMPR2, NR3C2
10actinomycin d4412.3NPR3, AGT, NOS3, NR3C2, NOS2, SGK1
11cholesterol44 28 11 2415.3ACE, CMA1, ACE2, HSD11B2, GNB3, NR3C2
12dexamethasone44 49 28 1115.3HSD11B2, NR3C2, EDN2, NPR3, SGK1, NOS2
13hydrochlorothiazide44 49 28 11 2416.1NEDD4L, ACE, AGT, NR3C2, GNB3, HSD11B2
14dopamine44 28 11 2415.1COMT, NR3C2, AGT, NPR3, SLC6A4, GRK4
15adenylate4412.0SGK1, HSD11B2, NPR3, EDN2, AGT, NOS2
16sildenafil44 49 28 11 2415.9ACE, NOS3, SLC6A4, NOS2, GNB3
17ang ii4411.9ACE, NOS2, NOS3, AGT, NR3C2
18cgmp44 2812.9EDN2, NOS2, NOS3, AGT, NPR3
19prostacyclin4411.9ACE, AGT, NOS3, EDN2, NOS2
20epinephrine44 11 2413.8EDN2, GNB3, COMT, SLC6A4, AGT
21spironolactone49 44 59 28 1115.7SGK1, HSD11B2, NR3C2, ACE
22nitroglycerin44 1112.7GNB3, NOS3, ACE, NOS2
23mifepristone44 59 28 1114.6HSD11B2, NR3C2, NOS3, SGK1
24captopril44 28 49 59 1115.5EDN2, ACE2, NR3C2
25norepinephrine44 11 2413.5SLC6A4, NR3C2, GNB3
26nebivolol44 1112.5NOS2, NOS3, ACE
27eplerenone44 59 28 1114.5ACE2, ACE, NR3C2
28enalaprilat4411.5AGT, ACE, ACE2
29lisinopril44 11 2413.5AGT, ACE, ACE2
30nadph44 2412.5HSD11B2, NR3C2, ACE2
31metoprolol44 28 49 11 2415.5GRK4, NOS3, ACE
32chymostatin4411.4CMA1, ACE, AGT
33thiazide4411.4NR3C2, ACE, GNB3
34perindopril44 49 1113.4NOS3, AGT, ACE
35n(g)-nitro-l-arginine methyl ester4411.4NOS2, NOS3, AGT
36ng-nitro-l-arginine4411.4AGT, NOS3, NOS2
37guanylate4411.3NOS3, AGT, NPR3, NOS2
38moexipril hydrochloride5911.2ACE, ACE2
39benazepril hydrochloride5911.1ACE2, ACE
40magnesium lithospermate b4411.1NOS2, NOS3
4111alpha-hydroxyprogesterone4411.1HSD11B2, NR3C2
42ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE1111.1NOS2, NOS3
43apocynin44 5912.1NOS3, AGT, NOS2
446-Nitroindazole1111.1NOS2, NOS3
45Ethylisothiourea1111.1NOS3, NOS2
46N,N-dimethylarginine1111.0NOS2, NOS3
475-Nitroindazole1111.0NOS2, NOS3
48chlorine44 2412.0SGK1, ACE, NPR3, ACE2
49candesartan44 28 1113.0AGT, ACE, NOS3
50perindopril erbumine5910.9ACE, ACE2

GO Terms for genes affiliated with Hypertension

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16Gene Ontology
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Biological processes related to Hypertension according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821712.0SGK1, ACSM3, ACE, NOS3, NPR3, GNB3
2regulation of cell proliferationGO:04212711.8SGK1, ACE2, NOS2, AGT, BMPR2
3angiotensin maturationGO:00200311.6AGT, CMA1, ACE, ACE2
4regulation of vasoconstrictionGO:01922911.6EDN2, AGT, ACE, ACE2
5blood vessel remodelingGO:00197411.6BMPR2, AGT, NOS3, ACE
6nitric oxide mediated signal transductionGO:00726311.4NOS2, NOS3, AGT
7regulation of renal output by angiotensinGO:00201911.2AGT, ACE
8angiotensin catabolic process in bloodGO:00200511.1ACE2, ACE
9angiotensin-mediated drinking behaviorGO:00305111.1ACE2, AGT
10positive regulation of guanylate cyclase activityGO:03128411.1NOS3, NOS2
11cellular sodium ion homeostasisGO:00688311.1NEDD4L, AGT
12negative regulation of systemic arterial blood pressureGO:00308511.1BMPR2, NEDD4L
13regulation of systemic arterial blood pressure by endothelinGO:00310011.0EDN2, NOS3
14regulation of systemic arterial blood pressure by renin-angiotensinGO:00308111.0ACE, ACE2
15artery smooth muscle contractionGO:01482410.9AGT, EDN2
16arginine catabolic processGO:00652710.9NOS2, NOS3
17response to salt stressGO:00965110.9AGT, NEDD4L
18regulation of vasodilationGO:04231210.8ACE, ACE2
19nitric oxide biosynthetic processGO:00680910.6NOS2, NOS3

Molecular functions related to Hypertension according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451711.0NOS2, NOS3
2peptidyl-dipeptidase activityGO:00824111.0ACE2, ACE
3arginine bindingGO:03461810.9NOS3, NOS2
4tetrahydrobiopterin bindingGO:03461710.9NOS3, NOS2
5FMN bindingGO:01018110.9NOS2, NOS3
6NADPH-hemoprotein reductase activityGO:00395810.8NOS2, NOS3
7carboxypeptidase activityGO:00418010.6ACE2, ACE

Products for genes affiliated with Hypertension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet