HTN
MCID: HYP075
MIFTS: 76

Hypertension (HTN) malady

Cardiovascular category

Summaries for Hypertension

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Blood pressure is the force of your blood pushing against the walls of your arteries. each time your heart beats, it pumps blood into the arteries. your blood pressure is highest when your heart beats, pumping the blood. this is called systolic pressure. when your heart is at rest, between beats, your blood pressure falls. this is called diastolic pressure. your blood pressure reading uses these two numbers. usually the systolic number comes before or above the diastolic number. a reading of 119/79 or lower is normal blood pressure 140/90 or higher is high blood pressure between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. high blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. you can control high blood pressure through healthy lifestyle habits and taking medicines, if needed. nih: national heart, lung, and blood institute

MalaCards: Hypertension, also known as high blood pressure, is related to portal hypertension and primary pulmonary hypertension. An important gene associated with Hypertension is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Insulin Processing. The drugs diltiazem and felodipine and the compounds sodium and nitric oxide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

CDC:3 About 1 in 3 U.S. adults—as estimated 68 million—have high blood pressure1, which increases the risk for heart disease and stroke, leading causes of death in the United States.2

Wikipedia:64 Hypertension (HTN) or high blood pressure, sometimes called arterial hypertension, is a chronic medical... more...

Description from OMIM:47 145500

Aliases & Classifications for Hypertension

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

hypertension 8 47 10
high blood pressure 8 34
vascular hypertensive disorder 8
hypertensive disease 61
hyperpiesia 8
htn 8


Related Diseases for Hypertension

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hypertension family:

benign essential hypertension malignant essential hypertension
essential hypertension malignant hypertension
familial hypertension hypertension, essential 3
hypertension, essential 7 hypertension, essential 6
hypertension, essential 4 hypertension, essential 2
hypertension, essential 1 hypertension, essential 8
hypertension, essential 5

Diseases related to Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1172)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension31.6NOS3
2primary pulmonary hypertension31.5SLC6A4, BMPR2
3hypertensive heart disease31.4NR3C2, ACE
4insulin resistance31.3AGT, GNB3, SGK1, ACE, NR3C2, HSD11B2
5nephrosclerosis31.0ACE, NR3C2
6atherosclerosis31.0GNB3, AGT, CMA1, ACE, COMT, NOS3
7vascular disease30.9NOS2
8coronary heart disease30.9COMT, GNB3, AGT, NOS3, ACE
9coronary artery disease,30.7NOS3, GNB3, AGT, ACE
10hepatopulmonary syndrome30.7NOS3
11hypokalemia30.7NR3C2, ACE, HSD11B2
12diabetic nephropathy30.7ACE2, ACE, NOS3, AGT, NR3C2, HSD11B2
13adenoma30.6GNB3, HSD11B2, BMPR2, NR3C2
14hypercholesterolemia30.6ACE, NOS2, NOS3, AGT, COMT, GNB3
15cushing's syndrome30.4NR3C2, HSD11B2
16sickle cell disease30.4NOS3
17liddle syndrome30.3NEDD4L
18acute myocardial infarction30.3NR3C2, AGT, ACE, SLC6A4
19uremia30.3NOS2, NOS3
20thromboembolism30.3NOS3
21intracranial aneurysm30.2ACE2, NOS3
22polycystic ovary syndrome30.2NR3C2
23nephritis30.2ACE
24pseudohypoaldosteronism30.1NR3C2, SGK1
25anuria30.1ACE
26asthma29.9NOS2, HSD11B2, CMA1
27apparent mineralocorticoid excess syndrome29.9NR3C2, HSD11B2
28colorectal cancer29.9COMT
29type 1 diabetes29.8AGT, ACE, HSD11B2, COMT
30focal segmental glomerulosclerosis29.8AGT, NOS2, ACE
31anxiety disorder29.8SLC6A4
32metabolic acidosis29.8NR3C2
33panic disorder29.7SLC6A4, NPR3, COMT
34adenocarcinoma29.7HSD11B2, NOS2
35cadasil29.5ACE, NR3C2, ACE2, GNB3, NOS3, AGT
36bipolar disorder29.4GNB3, COMT, SLC6A4
37pure autonomic failure29.4ACE, GNB3, NEDD4L
38renal tubular dysgenesis29.4ACE, AGT
39proliferative diabetic retinopathy29.4AGT
40renovascular hypertension11.0
41ocular hypertension11.0
42chronic thromboembolic pulmonary hypertension10.9
43hypertensive encephalopathy10.9
44hypertensive retinopathy10.7
45neurogenic hypertension10.7
46pediatric hypertension10.7
47familial hypertension10.7
48n syndrome10.7
49hypertension, diastolic10.6
50primary open angle glaucoma10.6

Graphical network of the top 20 diseases related to Hypertension:



Diseases related to hypertension

Clinical Features for Hypertension

Sources:
47OMIM
See all sources

Clinical features from OMIM:

145500

Drugs & Therapeutics for Hypertension

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypertension

Drug clinical trials:

Search ClinicalTrials for Hypertension

Search NIH Clinical Center for Hypertension

Search CenterWatch for Hypertension

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hypertension

Anatomical Context for Hypertension

Animal Models for Hypertension or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hypertension

Sources:
51PubMed
See all sources

Articles related to Hypertension:

(show top 50)    (show all 12874)
idTitleAuthorsYear
1
Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia. (24131296)
2014
2
Beneficial effects of tibolone on blood pressure and liver redox status in ovariectomized rats with renovascular hypertension. (23089337)
2013
3
Prevalence of diabetes and hypertension and association with various risk factors among different Muslim populations of Manipur, India. (24354866)
2013
4
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. (23453970)
2013
5
Genetic Variants on Rat Chromosome 8 Exhibit Profound Effects on Hypertension Severity and Survival During Nitric Oxide Inhibition in Spontaneously Hypertensive Rats. (24363279)
2013
6
A trend analysis of the prevalence, awareness, treatment, and control of hypertension by age group. (24349657)
2013
7
Letter to the editor about the reviewer comment to our article entitled 'Procalcitonin and the inflammatory response to salt in essential hypertension: a randomized cross-over clinical trial'. (23822930)
2013
8
PPARI+ activation in portal hypertension. (23115009)
2012
9
Predicting portal hypertension as assessed by acoustic radiation force impulse: correlations with the Doppler ultrasound. (22815421)
2012
10
Etiology and management of hemorrhagic complications of portal hypertension in children. (23097711)
2012
11
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. (22415303)
2012
12
Effect of endothelin A receptor antagonist on hepatic hemodynamics in cirrhotic rats. Implications for endothelin-1 in portal hypertension. (21769771)
2011
13
Dyskalaemia associated with thiopentone barbiturate coma for refractory intracranial hypertension: a case series. (21567112)
2011
14
Ocular hypertension and normal-tension glaucoma: time for banishment and burial. (21670346)
2011
15
Genetic variability of endothelin-1 system in gestational hypertension and preeclampsia]. (21851036)
2011
16
Fractal scaling of laser Doppler flowmetry time series in patients with essential hypertension. (21854788)
2011
17
Dyskeratosis congenita with portal hypertension of unknown etiology. (21755768)
2011
18
The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation. (21191291)
2011
19
High level of plasma endothelin-1 predicts development of hypertension in normotensive subjects. (20559285)
2010
20
Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. (20413632)
2010
21
Idiopathic intracranial hypertension in pregnancy. (20958297)
2010
22
Abdominal lymphatic tuberculosis and portal hypertension. (20810228)
2010
23
The frequency of anti-beta2-glycoprotein I antibodies is low and these antibodies are associated with pulmonary hypertension in mixed connective tissue disease. (19433462)
2009
24
Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. (19057444)
2009
25
High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension. (19420351)
2009
26
ACE inhibition in hypertension: focus on perindopril. (17953470)
2007
27
The concentration of atrial and brain natriuretic peptide in patients with idiopathic hypertension. (17901852)
2007
28
Bilateral renal artery entrapment by diaphragmatic crura: a rare cause of renovascular hypertension with a specific management. (17538300)
2007
29
Both angiotensinogen M235T and alpha-adducin G460W polymorphisms are associated with hypertension in the Japanese population. (17215849)
2007
30
A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. (17726486)
2007
31
Pretransplantation bone disease in patients with primary pulmonary hypertension. (16608950)
2006
32
The effect of bosentan on matrix metalloproteinase-9 levels in patients with systemic sclerosis-induced pulmonary hypertension. (15811199)
2005
33
Subclinical Cushing's disease accompanied by malignant hypertension and diabetes mellitus. (12132526)
2002
34
Changing patterns of initial drug therapy for the treatment of hypertension in a Medicaid population, 1997-2000. (12380636)
2002
35
Chronic thromboembolic pulmonary hypertension. (11893807)
2002
36
Genetic variation in the promoter region of the beta2 bradykinin receptor gene is associated with essential hypertension in a Chinese Han population. (11409654)
2001
37
Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension. (11136677)
2001
38
Rationale for angiotensin II receptor blockers in patients with low-renin hypertension. (10986156)
2000
39
Pulmonary thromboendarterectomy: an advance in the treatment of chronic thromboembolic pulmonary hypertension. (9777374)
1998
40
Plasma hydrogen peroxide production in hypertensives and normotensive subjects at genetic risk of hypertension. (9557922)
1998
41
Importance of the renin-angiotensin system in the generation of kidney failure in renovascular hypertension. (8986915)
1996
42
Study on the morphometric and hemodynamic changes of the pulmonary arteries in pulmonary hypertension autopsies]. (9206212)
1996
43
Effects of single intravenous administration of urapidil and diltiazem in patients with nonfixed pulmonary hypertension secondary to chronic obstructive lung disease. (7515999)
1994
44
Role of glucose intolerance in cardiac diastolic function in essential hypertension. (8206582)
1994
45
Restriction fragment length polymorphism of hsp70 gene, localized in the RT1 complex, is associated with hypertension in spontaneously hypertensive rats. (1350572)
1992
46
Malignant hypertension due to reflux nephropathy in an adolescent (a case report). (1784033)
1991
47
Effect of adrenergic beta receptor blockaders and thiazide diuretics on gastric acid and gastrin secretion in patients with essential hypertension]. (2216936)
1990
48
Erythrocyte sodium-lithium countertransport in primary and renal hypertension: relation to family history. (2499456)
1989
49
The glomerular mesangium in hypertension: a morphometrical comparison of nephrosclerosis with mesangioproliferative glomerulonephritis on renal biopsies. (813366)
1975
50
Treatment of malignant hypertension. The influence of etiology on the survival in 12 consecutive patients. (4819884)
1974

Genetic Variations for Hypertension

Expression for genes affiliated with Hypertension

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypertension

Search GEO for disease gene expression data for Hypertension.

Pathways for genes affiliated with Hypertension

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Hypertension

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1sodium45 2413.9HSD11B2, GNB3, NPR3, NEDD4L, NR3C2, AGT
2nitric oxide45 11 2414.9ACE, GNB3, ACE2, NPR3, BMPR2, EDN2
3cysteine4512.9NEDD4L, CMA1, SLC6A4, GRK4, AGT, COMT
4serine4512.9AGT, BMPR2, EDN2, GRK4, CMA1, SLC6A4
5calcium45 50 11 2415.8SGK1, EDN2, HSD11B2, NR3C2, AGT, CMA1
6arginine4512.7NOS2, NPR3, BMPR2, NR3C2, AGT, SLC6A4
7potassium45 11 2414.5GNB3, SGK1, ACE, AGT, EDN2, BMPR2
8glutamate4512.5GRK4, COMT, NEDD4L, NR3C2, SLC6A4, NOS3
9oxygen45 2413.5HSD11B2, ACE2, NOS2, NOS3, BMPR2, NR3C2
10actinomycin d4512.3NPR3, AGT, NOS3, NR3C2, NOS2, SGK1
11cholesterol45 29 11 2415.3ACE, CMA1, ACE2, HSD11B2, GNB3, NR3C2
12dexamethasone45 50 29 1115.3HSD11B2, NR3C2, EDN2, NPR3, SGK1, NOS2
13hydrochlorothiazide45 50 29 11 2416.1NEDD4L, ACE, AGT, NR3C2, GNB3, HSD11B2
14dopamine45 29 11 2415.1COMT, NR3C2, AGT, NPR3, SLC6A4, GRK4
15adenylate4512.0SGK1, HSD11B2, NPR3, EDN2, AGT, NOS2
16sildenafil45 50 29 11 2415.9ACE, NOS3, SLC6A4, NOS2, GNB3
17ang ii4511.9ACE, NOS2, NOS3, AGT, NR3C2
18cgmp45 2912.9EDN2, NOS2, NOS3, AGT, NPR3
19prostacyclin4511.9ACE, AGT, NOS3, EDN2, NOS2
20epinephrine45 11 2413.8EDN2, GNB3, COMT, SLC6A4, AGT
21spironolactone50 45 60 29 1115.7SGK1, HSD11B2, NR3C2, ACE
22nitroglycerin45 1112.7GNB3, NOS3, ACE, NOS2
23mifepristone45 60 29 1114.6HSD11B2, NR3C2, NOS3, SGK1
24captopril45 29 50 60 1115.5EDN2, ACE2, NR3C2
25norepinephrine45 11 2413.5SLC6A4, NR3C2, GNB3
26nebivolol45 1112.5NOS2, NOS3, ACE
27eplerenone45 60 29 1114.5ACE2, ACE, NR3C2
28enalaprilat4511.5AGT, ACE, ACE2
29lisinopril45 11 2413.5AGT, ACE, ACE2
30nadph45 2412.5HSD11B2, NR3C2, ACE2
31metoprolol45 29 50 11 2415.5GRK4, NOS3, ACE
32chymostatin4511.4CMA1, ACE, AGT
33thiazide4511.4NR3C2, ACE, GNB3
34perindopril45 50 1113.4NOS3, AGT, ACE
35n(g)-nitro-l-arginine methyl ester4511.4NOS2, NOS3, AGT
36ng-nitro-l-arginine4511.4AGT, NOS3, NOS2
37guanylate4511.3NOS3, AGT, NPR3, NOS2
38moexipril hydrochloride6011.2ACE, ACE2
39benazepril hydrochloride6011.1ACE2, ACE
40magnesium lithospermate b4511.1NOS2, NOS3
4111alpha-hydroxyprogesterone4511.1HSD11B2, NR3C2
42ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE1111.1NOS2, NOS3
43apocynin45 6012.1NOS3, AGT, NOS2
446-Nitroindazole1111.1NOS2, NOS3
45Ethylisothiourea1111.1NOS3, NOS2
46N,N-dimethylarginine1111.0NOS2, NOS3
475-Nitroindazole1111.0NOS2, NOS3
48chlorine45 2412.0SGK1, ACE, NPR3, ACE2
49candesartan45 29 1113.0AGT, ACE, NOS3
50perindopril erbumine6010.9ACE, ACE2

GO Terms for genes affiliated with Hypertension

Sources:
16Gene Ontology
See all sources

Biological processes related to Hypertension according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821712.0SGK1, ACSM3, ACE, NOS3, NPR3, GNB3
2regulation of cell proliferationGO:04212711.8SGK1, ACE2, NOS2, AGT, BMPR2
3angiotensin maturationGO:00200311.6AGT, CMA1, ACE, ACE2
4regulation of vasoconstrictionGO:01922911.6EDN2, AGT, ACE, ACE2
5blood vessel remodelingGO:00197411.6BMPR2, AGT, NOS3, ACE
6nitric oxide mediated signal transductionGO:00726311.4NOS2, NOS3, AGT
7regulation of renal output by angiotensinGO:00201911.2AGT, ACE
8angiotensin catabolic process in bloodGO:00200511.1ACE2, ACE
9angiotensin-mediated drinking behaviorGO:00305111.1ACE2, AGT
10positive regulation of guanylate cyclase activityGO:03128411.1NOS3, NOS2
11cellular sodium ion homeostasisGO:00688311.1NEDD4L, AGT
12negative regulation of systemic arterial blood pressureGO:00308511.1BMPR2, NEDD4L
13regulation of systemic arterial blood pressure by endothelinGO:00310011.0EDN2, NOS3
14regulation of systemic arterial blood pressure by renin-angiotensinGO:00308111.0ACE, ACE2
15artery smooth muscle contractionGO:01482410.9AGT, EDN2
16arginine catabolic processGO:00652710.9NOS2, NOS3
17response to salt stressGO:00965110.9AGT, NEDD4L
18regulation of vasodilationGO:04231210.8ACE, ACE2
19nitric oxide biosynthetic processGO:00680910.6NOS2, NOS3

Molecular functions related to Hypertension according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451711.0NOS2, NOS3
2peptidyl-dipeptidase activityGO:00824111.0ACE2, ACE
3arginine bindingGO:03461810.9NOS3, NOS2
4tetrahydrobiopterin bindingGO:03461710.9NOS3, NOS2
5FMN bindingGO:01018110.9NOS2, NOS3
6NADPH-hemoprotein reductase activityGO:00395810.8NOS2, NOS3
7carboxypeptidase activityGO:00418010.6ACE2, ACE

Products for genes affiliated with Hypertension

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  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertension

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet