HTN
MCID: HYP075
MIFTS: 87

Hypertension (HTN) malady

Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases categories
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Summaries for Hypertension

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MedlinePlus:33 Blood pressure is the force of your blood pushing against the walls of your arteries. each time your heart beats, it pumps blood into the arteries. your blood pressure is highest when your heart beats, pumping the blood. this is called systolic pressure. when your heart is at rest, between beats, your blood pressure falls. this is called diastolic pressure. your blood pressure reading uses these two numbers. usually the systolic number comes before or above the diastolic number. a reading of 119/79 or lower is normal blood pressure 140/90 or higher is high blood pressure between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. high blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. you can control high blood pressure through healthy lifestyle habits and taking medicines, if needed. nih: national heart, lung, and blood institute

MalaCards based summary: Hypertension, also known as vascular hypertensive disorder, is related to essential hypertension and hypertensive heart disease. An important gene associated with Hypertension is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Effects of nitric oxide and NO dependent CFTR activation normal and CF . The drugs diltiazem and felodipine and the compounds nebivolol and onoo have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are adipose tissue and muscle.

Wikipedia:65 Hypertension (HTN) or high blood pressure, sometimes called arterial hypertension, is a chronic medical... more...

Description from OMIM:46 145500

Aliases & Classifications for Hypertension

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Hypertension, Aliases & Descriptions:

Name: Hypertension 30 8 46 10
Vascular Hypertensive Disorder 8 62
High Blood Pressure 8 33
 
Hypertensive Disease 62
Hyperpiesia 8
Htn 8


Classifications:



Related Diseases for Hypertension

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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension Malignant Hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1319)
idRelated DiseaseScoreTop Affiliating Genes
1essential hypertension32.9GNB3, AGT
2hypertensive heart disease32.3ACE, NR3C2
3primary pulmonary hypertension32.3BMPR2, SLC6A4
4portal hypertension32.2BMPR2, NOS3
5pulmonary hypertension32.0EDN2, PTGIS, BMPR2, NOS2, NOS3, SLC6A4
6nephrosclerosis32.0NR3C2, ACE
7low renin hypertension32.0HSD11B2
8insulin resistance31.9GNB3, HSD11B2, SGK1, ACE, NR3C2, NOS3
9obesity31.9GNB3, HSD11B2, SGK1, COMT, NR3C2, NOS3
10diabetes mellitus31.9GNB3, SGK1, ACE, NR3C2, NOS3, AGT
11hyperaldosteronism31.8NR3C2, ACE, HSD11B2
12congenital heart disease31.6SLC6A4, NR3C2, ACE
13proteinuria31.6GNB3, HSD11B2, ACE, NR3C2, NOS3, AGT
14hypokalemia31.6HSD11B2, ACE, NR3C2
15type 2 diabetes mellitus31.5GNB3, SGK1, ACE, NOS3, AGT
16congestive heart failure31.4SGK1, ACE, NR3C2, NPR3, AGT
17liver cirrhosis31.4HSD11B2, NOS3, AGT
18cushing's syndrome31.3NR3C2, HSD11B2
19pre-eclampsia31.3EDN2, HSD11B2, NR3C2, NOS2, NOS3, SLC6A4
20liddle syndrome31.3HSD11B2, NEDD4L, NR3C2
21diabetic nephropathy31.3HSD11B2, SGK1, ACE, NR3C2, NOS3, AGT
22adenoma31.2GNB3, HSD11B2, PTGIS, BMPR2, NR3C2
23acute myocardial infarction31.2AGT, SLC6A4, NR3C2, ACE
24myocardial infarction31.1GNB3, PTGIS, ACE, COMT, NR3C2, NOS3
25anuria31.1ACE
26atherosclerosis31.0GNB3, PTGIS, CMA1, ACE, COMT, NR3C2
27hypercholesterolemia30.9GNB3, ACE, COMT, NOS2, NOS3, AGT
28gitelman syndrome30.8AGT
29ischemia30.8SGK1, PTGIS, NR3C2, NOS2, NOS3, AGT
30vascular disease30.8CMA1, ACE, BMPR2, NR3C2, NOS2, NOS3
31pseudohypoaldosteronism30.8SGK1, NR3C2
32hyperinsulinism30.8AGT, NOS3, SGK1
33cerebrovascular disease30.8GNB3, PTGIS, ACE, NR3C2, NOS3, AGT
34apparent mineralocorticoid excess syndrome30.8HSD11B2, NR3C2
35glomerulosclerosis30.7AGT, NOS2, ACE
36type 1 diabetes mellitus30.7AGT, COMT, ACE, HSD11B2
37breast cancer30.6EDN2, HSD11B2, SGK1, BMPR2, COMT, NR3C2
38panic disorder30.6COMT, NPR3, SLC6A4
39hyperglycemia30.6HSD11B2, SGK1, ACE, NOS2, NOS3, AGT
40renal tubular dysgenesis30.4ACE, AGT
41pure autonomic failure30.4GNB3, NEDD4L, ACE
42anxiety disorder30.4COMT, NR3C2, SLC6A4
43psychotic disorder30.4GNB3, COMT, SLC6A4
44diabetic retinopathy30.3ACE, NOS2, NOS3, AGT
45chronic kidney failure30.3EDN2, GNB3, HSD11B2, SGK1, ACE, NR3C2
46alzheimer's disease30.3SLC6A4, NOS3, NOS2, NR3C2, COMT
47focal segmental glomerulosclerosis30.1NOS2, ACE
48alcohol abuse30.1COMT, SLC6A4
49impotence30.0NOS2, NOS3
50intracranial hypertension11.1

Graphical network of the top 20 diseases related to Hypertension:



Diseases related to hypertension

Symptoms for Hypertension

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Clinical features from OMIM:

145500

Drugs & Therapeutics for Hypertension

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Drug clinical trials:

Search ClinicalTrials for Hypertension

Search NIH Clinical Center for Hypertension

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Hypertension

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Anatomical Context for Hypertension

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MalaCards organs/tissues related to Hypertension:

32
Heart, Endothelial, Kidney, Liver, Brain, Lung, Smooth muscle, Testes, Bone, Monocytes, Eye, Placenta, Spleen, Thyroid, Retina, Skeletal muscle, Skin, Neutrophil, Spinal cord, Ovary, Prostate, Colon, Pancreas, T cells, Adrenal gland, Cortex, Breast, Medulla oblongata, Myeloid, Hypothalamus, Pituitary, Bone marrow, Adrenal cortex, Lymph node, Whole blood, Thymus, Small intestine, B cells, Pons, Cerebellum, Adipocyte, Cervix, Prefrontal cortex, Thalamus, Cardiac myocytes, Tongue

Animal Models for Hypertension or affiliated genes

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Publications for Hypertension

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Articles related to Hypertension:

(show top 50)    (show all 15889)
idTitleAuthorsYear
1
Malignant hypertension and interferon-beta: a case report. (24067346)
2013
2
Myocardial performance index and aortic distensibility in patients with different left ventricle geometry in newly diagnosed essential hypertension. (23550550)
2013
3
Hypertension secondary to a periprostatic paraganglioma: case report and review of the literature. (24274233)
2013
4
Hepatic hemodynamics in 24 patients with nodular regenerative hyperplasia and symptomatic portal hypertension. (22554152)
2012
5
Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results. (22719761)
2012
6
Mortality and complications in patients with portal hypertension who underwent transjugular intrahepatic portosystemic shunt (TIPS) - 12 years experience. (22767002)
2012
7
Effects of the Ala379Val polymorphism of lipoprotein-associated phospholipase A2 on thrombosis and inflammation in hypertensive patients. (21880383)
2011
8
Response to intracranial hypertension treatment as a predictor of death in patients with severe traumatic brain injury. (21214327)
2011
9
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
10
Acute pulmonary hypertension in infants and children: cGMP-related drugs. (20216161)
2010
11
Idiopathic intracranial hypertension and facial palsy: case report and review of the literature. (20921567)
2010
12
Successful management of refractory intracranial hypertension from acute hyperammonemic encephalopathy in a woman with ornithine transcarbamylase deficiency. (20422467)
2010
13
The structural and functional consequences of diurnal variations in blood pressure in treated patients with hypertensive cerebrovascular disease. (19337131)
2009
14
Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. (19592461)
2009
15
Genetic variants of beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and essential hypertension in a south Indian Tamil population. (19673943)
2009
16
Pulmonary arterial hypertension: need to treat. (19075794)
2008
17
Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension. (16787197)
2006
18
Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. (16606791)
2006
19
Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. (15668187)
2005
20
Effects of streptozotocin and dietary fructose on delta-6 desaturation in spontaneously hypertensive rat liver. (15589689)
2004
21
Phosphodiesterase inhibitors in the management of primary pulmonary hypertension. (15133384)
2004
22
What is new in the treatment of pulmonary artery hypertension?]. (12966661)
2003
23
A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension. (12714866)
2003
24
Effect of angiotensin II type 1 receptor antagonist on oxidative stress markers in type 2 diabetic patients with hypertension]. (12877092)
2003
25
Blood pressure increase and incidence of hypertension in relation to inflammation-sensitive plasma proteins. (12482834)
2002
26
Choledocholithiasis in the Setting of Portal Hypertension. (11469971)
2001
27
Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis. (10702650)
1999
28
Doppler sonographic findings for hypertension in pregnancy and HELLP syndrome. (10642960)
1999
29
Adrenomedullin and membrane fluidity of erythrocytes in mild essential hypertension. (10067789)
1999
30
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine. (10574416)
1999
31
Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. (10400907)
1999
32
Primary pulmonary hypertension: pathologist as patient. (9670148)
1998
33
Study on relationship between detection of interleukin-6 and its mRNA and pregnancy induced hypertension]. (10806655)
1998
34
Angiotensin-converting enzyme deletion polymorphism is associated with hypertension in a Sikh population. (9358012)
1997
35
A comparison of outcome criteria in the diagnosis of renovascular hypertension. (8989973)
1996
36
Hypertension and atherosclerosis. (8872835)
1996
37
Urinary excretion rate of endothelin-1 in patients with essential hypertension and salt sensitivity. (8164445)
1994
38
Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma. (8023829)
1994
39
Mechanisms of renal hypertension and renal contribution to primary hypertension. (8116014)
1993
40
Responsiveness to alpha- and beta-adrenergic receptor agonists. Effects of race in borderline hypertensive compared to normotensive men. (8398005)
1993
41
Renal effects of atrial natriuretic peptide during dopa-decarboxylase inhibition in patients with essential hypertension. (8359177)
1993
42
Percutaneous transluminal renal artery angioplasty (PTRA) in hypertensive encephalopathy. (6223006)
1983
43
Malignant hypertension and cigarette smoking. (427451)
1979
44
A controlled, double-blind study of dl-alpha-tocopheryl nicotinate (Juvela-Nicotinate) for treatment of symptoms in hypertension and cerebral arteriosclerosis. (881743)
1977
45
On the pathogenesis of hypertensive encephalopathy as revealed by cerebral blood flow studies in man. (928747)
1977
46
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977
47
Pathogenesis of malignant hypertension: experimental evidence from the renal hypertensive rat. (1192618)
1975
48
Partial splenectomy and pleural splenic transposition, a new approach to congestive hypersplenism of portal hypertension. (5037265)
1972
49
Successful twin pregnancy after treatment of malignant essential hypertension. (13572832)
1958
50
Abdominal epilepsy; diencephalic syndrome, pseudotabes, pupillary anomalies, alterations of reflexes, severe visceral algias, morbid hunger, and juvenile arterial hypertension; observation of a familial picture of five individuals. (13248674)
1954

Variations for Hypertension

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Clinvar genetic disease variations for Hypertension:

6
id Gene Name Type Significance SNP ID Assembly Location
1PTGISPTGIS, IVS9, T-C, +2single nucleotide variantPathogenic

Expression for genes affiliated with Hypertension

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Expression patterns in normal tissues for genes affiliated with Hypertension

Search GEO for disease gene expression data for Hypertension.

Pathways for genes affiliated with Hypertension

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Pathways related to Hypertension according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis37
10.4NOS2, NOS3
210.4NOS3, NOS2
3
Show member pathways
10.4NOS3, NOS2
410.4NOS3, NOS2
5
Show member pathways
10.3GNB3, NOS2, NOS3
6
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
10.3NOS3, NOS2, CPS1
7
Show member pathways
10.3GNB3, CMA1, ACE, AGT
8
Show member pathways
10.2GNB3, COMT, GRK4, SLC6A4
9
Show member pathways
10.2AGT, NOS3, NR3C2, ACE, CMA1
1010.2HSD11B2, SGK1, NEDD4L, NR3C2
11
Show member pathways
10.0GNB3, PTGIS, CPS1, ACSM3, COMT, NOS2

Compounds for genes affiliated with Hypertension

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Compounds related to Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1nebivolol44 1111.7NOS2, NOS3, ACE
2onoo4410.7PTGIS, NOS3, NOS2
3metoprolol44 50 28 24 1114.7ACE, GRK4, NOS3
4chymostatin4410.7CMA1, AGT, ACE
5perindopril44 50 1112.7NOS3, AGT, ACE
6nitroglycerin44 1111.7NOS2, NOS3, ACE, PTGIS, GNB3
7ang ii4410.7ACE, NR3C2, NOS3, AGT, NOS2
8sildenafil28 44 50 24 1114.7NOS2, SLC6A4, ACE, NOS3, GNB3
9n(g)-nitro-l-arginine methyl ester4410.7NOS2, NOS3, AGT
10thiazide4410.7GNB3, ACE, NR3C2
11spironolactone44 61 28 50 1114.7HSD11B2, ACE, SGK1, NR3C2
12captopril44 61 50 28 1114.7ACE, EDN2, NR3C2, AGT
13atenolol44 50 28 24 1114.6GNB3, ACE, AGT
14magnesium lithospermate b4410.6NOS2, NOS3
15ng-nitro-l-arginine4410.6NOS2, NOS3, AGT
1611alpha-hydroxyprogesterone4410.6NR3C2, HSD11B2
17cgmp44 2811.6AGT, NPR3, NOS3, NOS2, EDN2
18prostacyclin4410.6EDN2, PTGIS, ACE, NOS2, NOS3, AGT
19mifepristone44 28 61 1113.6SGK1, NR3C2, HSD11B2, NOS3
20hydrochlorothiazide44 28 50 24 1114.6NEDD4L, AGT, NR3C2, GNB3, HSD11B2, ACE
21candesartan44 50 28 1113.6AGT, ACE, NOS3
22guanylate4410.6NOS2, NOS3, NPR3, AGT
23apocynin44 6111.6NOS3, NOS2, AGT
24epinephrine44 24 1112.5GNB3, EDN2, AGT, SLC6A4, COMT
25amlodipine44 50 24 1113.5ACE, AGT, NOS3
26actinomycin d4410.5NOS3, HSD11B2, NR3C2, NOS2, NPR3, AGT
27norepinephrine44 24 1112.5AGT, HSD11B2, ACE, GNB3, COMT, SLC6A4
28acetylcholine44 50 28 24 1114.5NOS3, ACE, EDN2, NOS2, AGT
29enalapril44 50 1112.5ACE, NR3C2, AGT
30cholesterol44 28 24 1113.5NR3C2, AGT, ACE, CMA1, PTGIS, HSD11B2
31oxygen44 2411.5PTGIS, AGT, NOS3, NOS2, NR3C2, BMPR2
32adenylate4410.5EDN2, HSD11B2, AGT, NPR3, SGK1, NOS2
33dopamine44 28 24 1113.5COMT, GNB3, AGT, SLC6A4, NPR3, GRK4
34potassium44 24 1112.5SGK1, EDN2, ACE, BMPR2, HSD11B2, NR3C2
35ketamine44 28 1112.5SLC6A4, NOS3, EDN2
36dexamethasone44 50 28 1113.5AGT, NPR3, NR3C2, SGK1, HSD11B2, NOS2
37remikiren44 1111.4AGT, ACE
38citrulline44 2411.4NOS2, CPS1, NOS3
39glutamate4410.4NOS3, NEDD4L, COMT, SGK1, GRK4, NOS2
40glucose4410.4NR3C2, HSD11B2, AGT, SGK1, GNB3, ACE
41nitric oxide44 24 1112.4NR3C2, ACE, PTGIS, GNB3, EDN2, NPR3
42n5-(1-iminoethyl)-l-ornithine4410.4NOS2, NOS3
43s-ethylisothiourea44 1111.4NOS2, NOS3
44arginine4410.4AGT, HSD11B2, SGK1, NR3C2, NOS2, NOS3
45serine4410.3EDN2, HSD11B2, SGK1, CMA1, BMPR2, AGT
46sodium44 2411.3GNB3, SGK1, NEDD4L, ACE, NR3C2, GRK4
47cysteine4410.3COMT, AGT, NR3C2, SLC6A4, GRK4, CMA1
48calcium44 50 24 1113.3AGT, NPR3, NOS3, EDN2, HSD11B2, NOS2
49nitrit4410.3NOS2, NOS3
50l-thiocitrulline44 1111.1NOS2, NOS3

GO Terms for genes affiliated with Hypertension

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Cellular components related to Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:00590110.3NOS3, BMPR2, PTGIS

Biological processes related to Hypertension according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal output by angiotensinGO:00201910.7ACE, AGT
2nitric oxide mediated signal transductionGO:00726310.7NOS2, NOS3, AGT
3regulation of systemic arterial blood pressure by endothelinGO:00310010.7NOS3, EDN2
4angiotensin maturationGO:00200310.7AGT, ACE, CMA1
5positive regulation of guanylate cyclase activityGO:03128410.7NOS2, NOS3
6regulation of vasoconstrictionGO:01922910.7EDN2, ACE, AGT
7blood vessel remodelingGO:00197410.6ACE, BMPR2, NOS3, AGT
8cellular sodium ion homeostasisGO:00688310.6AGT, NEDD4L
9positive regulation of vasodilationGO:04590910.6NOS3, NOS2, CPS1
10negative regulation of systemic arterial blood pressureGO:00308510.6NEDD4L, BMPR2
11arginine catabolic processGO:00652710.6NOS2, NOS3
12artery smooth muscle contractionGO:01482410.6EDN2, AGT
13regulation of cell proliferationGO:04212710.6SGK1, BMPR2, NOS2, AGT
14nitric oxide biosynthetic processGO:00680910.6NOS3, NOS2
15positive regulation of angiogenesisGO:04576610.5PTGIS, CMA1, NOS3
16response to foodGO:03209410.5HSD11B2, CPS1
17regulation of blood pressureGO:00821710.5NPR3, NOS3, ACSM3, ACE, SGK1, GNB3
18response to salt stressGO:00965110.5NEDD4L, AGT
19response to drugGO:04249310.4SLC6A4, COMT, CPS1, HSD11B2
20prostaglandin biosynthetic processGO:00151610.4EDN2, PTGIS
21vasoconstrictionGO:04231010.4SLC6A4, EDN2
22response to hypoxiaGO:00166610.3SLC6A4, NOS2, HSD11B2
23nitric oxide metabolic processGO:04620910.1NOS3, CPS1
24small molecule metabolic processGO:04428110.0GNB3, PTGIS, CPS1, COMT, NOS3, AGT

Molecular functions related to Hypertension according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451710.6NOS3, NOS2
2tetrahydrobiopterin bindingGO:03461710.6NOS3, NOS2
3arginine bindingGO:03461810.6NOS3, NOS2
4NADPH-hemoprotein reductase activityGO:00395810.5NOS3, NOS2
5FMN bindingGO:01018110.5NOS3, NOS2
6steroid bindingGO:00549610.4NR3C2, HSD11B2
7heme bindingGO:02003710.3PTGIS, NOS2, NOS3
8iron ion bindingGO:00550610.2NOS3, NOS2, PTGIS
9sodium channel regulator activityGO:01708010.0NEDD4L, SGK1
10protein bindingGO:0055159.9ACE, NEDD4L, CPS1, PTGIS, GNB3, BMPR2

Products for genes affiliated with Hypertension

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  • Antibodies
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  • Lysates

Sources for Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet