HTN
MCID: HYP075
MIFTS: 86

Hypertension (HTN) malady

Cardiovascular diseases, Blood diseases categories

Summaries for Hypertension

About this section
Sources:
33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Blood pressure is the force of your blood pushing against the walls of your arteries. each time your heart beats, it pumps blood into the arteries. your blood pressure is highest when your heart beats, pumping the blood. this is called systolic pressure. when your heart is at rest, between beats, your blood pressure falls. this is called diastolic pressure. your blood pressure reading uses these two numbers. usually the systolic number comes before or above the diastolic number. a reading of 119/79 or lower is normal blood pressure 140/90 or higher is high blood pressure between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. high blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. you can control high blood pressure through healthy lifestyle habits and taking medicines, if needed. nih: national heart, lung, and blood institute

MalaCards: Hypertension, also known as high blood pressure, is related to essential hypertension and portal hypertension. An important gene associated with Hypertension is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Insulin Processing. The drugs acebutolol and amiloride and the compounds sodium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

CDC:3 High blood pressure is a common and dangerous condition. Having high blood pressure means the pressure of the blood in your blood vessels is higher than it should be. But you can take steps to control your blood pressure and lower your risk.

Wikipedia:63 Hypertension (HTN) or high blood pressure, sometimes called arterial hypertension, is a chronic medical... more...

Description from OMIM:46 145500

Aliases & Classifications for Hypertension

About this section
Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


Aliases & Descriptions:

hypertension 8 46 10
high blood pressure 8 33
vascular hypertensive disorder 8
hypertensive disease 60
hyperpiesia 8
htn 8


Related Diseases for Hypertension

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension Malignant Hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1132)
idRelated DiseaseScoreTop Affiliating Genes
1essential hypertension31.9AGT, GNB3
2portal hypertension31.6NOS3
3primary pulmonary hypertension31.5SLC6A4, BMPR2
4hypertensive heart disease31.4NR3C2, ACE
5glaucoma31.3HSD11B2, BMPR2
6obesity31.3SGK1, COMT, HSD11B2, GNB3, NPR3, NR3C2
7diabetes mellitus31.2GNB3, NR3C2, AGT, NOS3, ACE, SGK1
8nephrosclerosis31.0ACE, NR3C2
9atherosclerosis31.0GNB3, AGT, CMA1, ACE, COMT, NOS3
10pre-eclampsia30.9NOS3, NOS2, EDN2, AGT, HSD11B2, NR3C2
11proteinuria30.9NR3C2, HSD11B2, GNB3, AGT, NOS3, ACE
12vascular disease30.9NOS2
13hyperaldosteronism30.8HSD11B2, NR3C2, ACE
14type 2 diabetes mellitus30.8GNB3, ACE, SGK1, NOS3, AGT
15liver cirrhosis30.8HSD11B2, AGT, NOS3
16myocardial infarction30.7COMT, NR3C2, SLC6A4, ACE2, ACE, NOS3
17diabetic nephropathy30.7ACE2, ACE, NOS3, AGT, NR3C2, HSD11B2
18coronary artery disease30.7NOS3, GNB3, AGT, ACE
19ischemia30.7NOS2, NOS3, NR3C2, SGK1, AGT
20hepatopulmonary syndrome30.7NOS3
21hypokalemia30.6NR3C2, ACE, HSD11B2
22adenoma30.6GNB3, HSD11B2, BMPR2, NR3C2
23glomerulonephritis30.5NOS2
24congestive heart failure30.5SGK1, ACE, NPR3, NR3C2, AGT
25ischemic heart disease30.4ACE, NOS2, NOS3, AGT
26cushing's syndrome30.4NR3C2, HSD11B2
27sickle cell disease30.3NOS3
28sarcoidosis30.3ACE
29cerebrovascular disease30.3ACE
30liddle syndrome30.3NEDD4L
31acute myocardial infarction30.3NR3C2, AGT, ACE, SLC6A4
32nephrotic syndrome30.3AGT, ACE
33uremia30.3NOS2, NOS3
34dementia30.3COMT
35diabetic retinopathy30.2AGT, NOS3, NOS2, ACE
36migraine30.2SLC6A4, COMT
37intracranial aneurysm30.2ACE2, NOS3
38hyperglycemia30.2ACE, HSD11B2, AGT, NOS2, NOS3, SGK1
39polycystic ovary syndrome30.2NR3C2
40dilated cardiomyopathy30.2ACE
41peritonitis30.1CMA1
42pseudohypoaldosteronism30.1NR3C2, SGK1
43anuria30.1ACE
44chronic kidney failure30.0HSD11B2, ACE, NOS3, AGT, NR3C2, EDN2
45congenital heart defect30.0CMA1, AGT, ACE, NR3C2, NOS3
46breast cancer29.9SGK1, HSD11B2, AGT, NR3C2, COMT, BMPR2
47asthma29.9NOS2, HSD11B2, CMA1
48apparent mineralocorticoid excess syndrome29.9NR3C2, HSD11B2
49colorectal cancer29.9COMT
50prostate cancer29.8NOS3, COMT, BMPR2, NR3C2

Graphical network of the top 20 diseases related to Hypertension:



Diseases related to hypertension

Clinical Features for Hypertension

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

145500

Drugs & Therapeutics for Hypertension

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypertension

Drug clinical trials:

Search ClinicalTrials for Hypertension

Search NIH Clinical Center for Hypertension

Search CenterWatch for Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypertension

About this section

Anatomical Context for Hypertension

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hypertension:

32
Heart, Endothelial, Kidney, Brain, Liver, Lung, Testes, Smooth muscle, Bone, Monocytes, Eye, Placenta, Spleen, Thyroid, Skeletal muscle, Retina, Skin, Prostate, Ovary, Spinal cord, Colon, Pancreas, T cells, Adrenal gland, Breast, Cortex, Medulla oblongata, Pituitary, Hypothalamus, Myeloid, Bone marrow, Adrenal cortex, Lymph node, B cells, Small intestine, Whole blood, Thymus, Pons, Cardiac myocytes, Tongue, Thalamus, Prefrontal cortex, Cerebellum, Adipocyte, Cervix

Animal Models for Hypertension or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537613.2NEDD4L, BMPR2, NPR3, HSD11B2, COMT, NR3C2
2MP:000538513.1NEDD4L, BMPR2, NPR3, HSD11B2, COMT, NR3C2
3MP:001076812.9NEDD4L, BMPR2, NPR3, GNB3, HSD11B2, NR3C2
4MP:000536712.9SGK1, COMT, HSD11B2, NPR3, NEDD4L, NR3C2
5MP:000538612.4COMT, HSD11B2, NPR3, NEDD4L, NR3C2, AGT
6MP:000536912.4HSD11B2, BMPR2, NEDD4L, NR3C2, AGT, SLC6A4
7MP:000538712.0COMT, NPR3, BMPR2, NEDD4L, AGT, CMA1
8MP:000537511.5ACE, NOS2, NOS3, AGT, NPR3

Publications for Hypertension

About this section
Sources:
50PubMed
See all sources

Articles related to Hypertension:

(show top 50)    (show all 15549)
idTitleAuthorsYear
1
Predictors of bronchopulmonary dysplasia and pulmonary hypertension in newborn children. (23905570)
2013
2
Specific Management of Anemia and Hypertension in Renal Transplant Recipients: Influence of Renin-Angiotensin System Blockade. (24356394)
2013
3
Sodium in drugs and hypertension. (24326889)
2013
4
Noncirrhotic portal hypertension associated with didanosine: a case report and literature review. (22274160)
2012
5
Terlipressin improves pulmonary pressures in cirrhotic patients with pulmonary hypertension and variceal bleeding or hepatorenal syndrome. (22893473)
2012
6
Surgical management of portal hypertension in children. (22800975)
2012
7
Hereditary hemorrhagic telangiectasia presenting as portal hypertension. (22453075)
2012
8
Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis. (21930186)
2012
9
IOP change undergoing anesthesia in rhesus macaques (Macaca mulatta) with laser-induced ocular hypertension. (22673087)
2012
10
Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. (21616950)
2011
11
Different characteristics of peripartum cardiomyopathy between patients complicated with and without hypertensive disorders. -Results from the Japanese Nationwide survey of peripartum cardiomyopathy-. (21617320)
2011
12
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension. (21037114)
2011
13
Intra-abdominal Hypertension and Abdominal Compartment Syndrome. (21184922)
2011
14
Prolonged enhancement of the subarachnoid space on FLAIR imaging in hypertensive encephalopathy. (21510244)
2011
15
Novel genetic variation in exon 28 of FBN1 gene is associated with essential hypertension. (21331051)
2011
16
A patient with Crohn's disease and portal hypertension. Nodular regenerative hyperplasia. (21276765)
2011
17
Microenvironment and macroenvironment in hypertensive hearts: boundaries and silos--can we pick and treat diastolic heart failure? (20404215)
2010
18
Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. (20176994)
2010
19
Non-alcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in essential hypertension. (19278843)
2009
20
Xylosyltransferase gene variants and their role in essential hypertension. (19197251)
2009
21
When ballooning alone is enough: successful treatment of hypertension secondary to renal artery fibromuscular dysplasia using angioplasty. (17945366)
2009
22
Urinary cortisol/cortisone ratios in hypertensive and normotensive cats. (19058985)
2009
23
Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]. (18260994)
2008
24
Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia. (18496130)
2008
25
Radiology case of the month. Right hemiplegia and hypertension. Hyperacute left middle cerebral artery stroke. (17987955)
2007
26
Bosentan in Eisenmenger syndrome and chronic thromboembolic pulmonary hypertension. (16919009)
2006
27
Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension. (14736447)
2004
28
Role of mr angiography in the evaluation of renovascular hypertension. (15055333)
2004
29
Haplotype analysis of the prostacyclin synthase gene and essential hypertension. (12924623)
2003
30
Plasminogen activation by blood monocytes and alveolar macrophages in primary pulmonary hypertension. (12138369)
2002
31
Clinical experience with Sorin Bicarbon valve in patients with tight mitral valve stenosis and elevated pulmonary hypertension (early and mid-term results). (12124546)
2002
32
Glucocorticoid-remediable aldosteronism is associated with severe hypertension in early childhood. (11343049)
2001
33
Genetic forms of human hypertension. (11458030)
2001
34
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension. (11693765)
2001
35
ACE/DD genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial dysfunction in patients with untreated hypertension. (11054622)
2000
36
ACE inhibition scintigraphy in the management of hypertension in children. (10452277)
1999
37
The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis. (9504863)
1998
38
Metabolic effects of long-term treatments with nifedipine-retard and captopril in young hypertensive patients. (9194505)
1997
39
Effect of qigong on heart-qi deficiency and blood stasis type of hypertension and its mechanism]. (8580689)
1995
40
Clinic and 24h blood pressure in elderly treated hypertensives with postural hypotension. (7807502)
1994
41
Plasma atrial natriuretic peptide levels in elderly hypertensives: effects of blood pressure reduction with amlodipine. (15374267)
1994
42
Autoantibodies against cardiac G-protein-coupled receptors define different populations with cardiomyopathies but not with hypertension. (8020188)
1994
43
Disparate structural effects on left and right ventricles by angiotensin-converting enzyme inhibitors and calcium antagonists in essential hypertension. (8141090)
1994
44
Renal haemodynamics and organ damage in young hypertensive patients with different plasma renin activities after ACE inhibition. (1314992)
1992
45
Predicting hypertensive heart disease via non-invasive methodology: relationship between ambulatory blood pressure and cardiac indices derived by echocardiography and radionuclide ventriculography. (2150531)
1990
46
Relationship between hypertension and subtle and overt abnormalities of carbohydrate metabolism. (16989076)
1990
47
Unilateral supernumerary kidney associated with hypertensive encephalopathy in a child. (6646892)
1983
48
Post traumatic renal hypertension. (6357172)
1983
49
Central action of acetylcholine on the behavior, pain threshold and duration of electrical convulsions in rats with renal hypertension. (752243)
1978
50
Editorial: New prospects in renal hypertension. (1139228)
1975

Genetic Variations for Hypertension

About this section

Expression for genes affiliated with Hypertension

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypertension

Search GEO for disease gene expression data for Hypertension.

Pathways for genes affiliated with Hypertension

About this section
Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 29KEGG
See all sources

Compounds for genes affiliated with Hypertension

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1sodium44 2413.9HSD11B2, GNB3, NPR3, NEDD4L, NR3C2, AGT
2nitric oxide44 11 2414.9ACE, GNB3, ACE2, NPR3, BMPR2, EDN2
3cysteine4412.9NEDD4L, CMA1, SLC6A4, GRK4, AGT, COMT
4serine4412.9AGT, BMPR2, EDN2, GRK4, CMA1, SLC6A4
5calcium44 49 11 2415.8SGK1, EDN2, HSD11B2, NR3C2, AGT, CMA1
6arginine4412.7NOS2, NPR3, BMPR2, NR3C2, AGT, SLC6A4
7potassium44 11 2414.5GNB3, SGK1, ACE, AGT, EDN2, BMPR2
8glutamate4412.5GRK4, COMT, NEDD4L, NR3C2, SLC6A4, NOS3
9oxygen44 2413.5HSD11B2, ACE2, NOS2, NOS3, BMPR2, NR3C2
10actinomycin d4412.3NPR3, AGT, NOS3, NR3C2, NOS2, SGK1
11cholesterol44 28 11 2415.3ACE, CMA1, ACE2, HSD11B2, GNB3, NR3C2
12dexamethasone44 49 28 1115.3HSD11B2, NR3C2, EDN2, NPR3, SGK1, NOS2
13hydrochlorothiazide44 49 28 11 2416.1NEDD4L, ACE, AGT, NR3C2, GNB3, HSD11B2
14dopamine44 28 11 2415.1COMT, NR3C2, AGT, NPR3, SLC6A4, GRK4
15adenylate4412.0SGK1, HSD11B2, NPR3, EDN2, AGT, NOS2
16sildenafil44 49 28 11 2415.9ACE, NOS3, SLC6A4, NOS2, GNB3
17ang ii4411.9ACE, NOS2, NOS3, AGT, NR3C2
18cgmp44 2812.9EDN2, NOS2, NOS3, AGT, NPR3
19prostacyclin4411.9ACE, AGT, NOS3, EDN2, NOS2
20epinephrine44 11 2413.8EDN2, GNB3, COMT, SLC6A4, AGT
21spironolactone49 44 59 28 1115.7SGK1, HSD11B2, NR3C2, ACE
22nitroglycerin44 1112.7GNB3, NOS3, ACE, NOS2
23mifepristone44 59 28 1114.6HSD11B2, NR3C2, NOS3, SGK1
24captopril44 28 49 59 1115.5EDN2, ACE2, NR3C2
25norepinephrine44 11 2413.5SLC6A4, NR3C2, GNB3
26nebivolol44 1112.5NOS2, NOS3, ACE
27eplerenone44 59 28 1114.5ACE2, ACE, NR3C2
28enalaprilat4411.5AGT, ACE, ACE2
29lisinopril44 11 2413.5AGT, ACE, ACE2
30nadph44 2412.5HSD11B2, NR3C2, ACE2
31metoprolol44 28 49 11 2415.5GRK4, NOS3, ACE
32chymostatin4411.4CMA1, ACE, AGT
33thiazide4411.4NR3C2, ACE, GNB3
34perindopril44 49 1113.4NOS3, AGT, ACE
35n(g)-nitro-l-arginine methyl ester4411.4NOS2, NOS3, AGT
36ng-nitro-l-arginine4411.4AGT, NOS3, NOS2
37guanylate4411.3NOS3, AGT, NPR3, NOS2
38moexipril hydrochloride5911.2ACE, ACE2
39benazepril hydrochloride5911.1ACE2, ACE
40magnesium lithospermate b4411.1NOS2, NOS3
4111alpha-hydroxyprogesterone4411.1HSD11B2, NR3C2
42ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE1111.1NOS2, NOS3
43apocynin44 5912.1NOS3, AGT, NOS2
446-Nitroindazole1111.1NOS2, NOS3
45Ethylisothiourea1111.1NOS3, NOS2
46N,N-dimethylarginine1111.0NOS2, NOS3
475-Nitroindazole1111.0NOS2, NOS3
48chlorine44 2412.0SGK1, ACE, NPR3, ACE2
49candesartan44 28 1113.0AGT, ACE, NOS3
50perindopril erbumine5910.9ACE, ACE2

GO Terms for genes affiliated with Hypertension

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Hypertension according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821712.0SGK1, ACSM3, ACE, NOS3, NPR3, GNB3
2regulation of cell proliferationGO:04212711.8SGK1, ACE2, NOS2, AGT, BMPR2
3angiotensin maturationGO:00200311.6AGT, CMA1, ACE, ACE2
4regulation of vasoconstrictionGO:01922911.6EDN2, AGT, ACE, ACE2
5blood vessel remodelingGO:00197411.6BMPR2, AGT, NOS3, ACE
6nitric oxide mediated signal transductionGO:00726311.4NOS2, NOS3, AGT
7regulation of renal output by angiotensinGO:00201911.2AGT, ACE
8angiotensin catabolic process in bloodGO:00200511.1ACE2, ACE
9angiotensin-mediated drinking behaviorGO:00305111.1ACE2, AGT
10positive regulation of guanylate cyclase activityGO:03128411.1NOS3, NOS2
11cellular sodium ion homeostasisGO:00688311.1NEDD4L, AGT
12negative regulation of systemic arterial blood pressureGO:00308511.1BMPR2, NEDD4L
13regulation of systemic arterial blood pressure by endothelinGO:00310011.0EDN2, NOS3
14regulation of systemic arterial blood pressure by renin-angiotensinGO:00308111.0ACE, ACE2
15artery smooth muscle contractionGO:01482410.9AGT, EDN2
16arginine catabolic processGO:00652710.9NOS2, NOS3
17response to salt stressGO:00965110.9AGT, NEDD4L
18regulation of vasodilationGO:04231210.8ACE, ACE2
19nitric oxide biosynthetic processGO:00680910.6NOS2, NOS3

Molecular functions related to Hypertension according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451711.0NOS2, NOS3
2peptidyl-dipeptidase activityGO:00824111.0ACE2, ACE
3arginine bindingGO:03461810.9NOS3, NOS2
4tetrahydrobiopterin bindingGO:03461710.9NOS3, NOS2
5FMN bindingGO:01018110.9NOS2, NOS3
6NADPH-hemoprotein reductase activityGO:00395810.8NOS2, NOS3
7carboxypeptidase activityGO:00418010.6ACE2, ACE

Products for genes affiliated with Hypertension

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertension

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet