Aliases & Classifications for Hypertension, Diastolic

Aliases & Descriptions for Hypertension, Diastolic:

Name: Hypertension, Diastolic 54
Hypertension, Diastolic, Resistance to 29 13
Diastolic Hypertension 52 69

Characteristics:

HPO:

32
hypertension, diastolic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 608622

Summaries for Hypertension, Diastolic

MalaCards based summary : Hypertension, Diastolic, also known as hypertension, diastolic, resistance to, is related to hypertrophic elongation of cervix and hypotrichosis simplex, and has symptoms including elevated diastolic blood pressure An important gene associated with Hypertension, Diastolic is KCNMB1 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1), and among its related pathways/superpathways are Potassium Channels and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Irbesartan and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include heart and endothelial, and related phenotypes are renal/urinary system and reproductive system

Description from OMIM: 608622

Related Diseases for Hypertension, Diastolic

Diseases related to Hypertension, Diastolic via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 hypertrophic elongation of cervix 10.1 ACE GGT1
2 hypotrichosis simplex 10.1 ACE REN
3 hyperinsulinemic hypoglycemia, familial, 3 10.1 ACE REN
4 carbohydrate metabolic disorder 10.1 ACE REN
5 hypogonadism mitral valve prolapse mental retardation 10.1 ACE REN
6 listeriosis 10.1 ACE REN
7 dientamoebiasis 10.1 ACE REN
8 iris disease 10.1 ACE REN
9 congenital nystagmus 10.1 ACE REN
10 prostate neuroendocrine neoplasm 10.1 ACE REN
11 cascade stomach 10.1 ACE REN
12 hyperuricemic nephropathy, familial juvenile 2 10.1 ACE REN
13 chylocele of tunica vaginalis 10.1 ACE REN
14 eastern equine encephalitis 10.1 ACE REN
15 myopia 10.1 ACE REN
16 flat umbilicus familial 10.1 ACE REN
17 petrositis 10.1 ACE REN
18 lymphadenitis 10.1 ACE REN
19 pythiosis 10.1 ACE REN
20 microphthalmia, isolated, with coloboma 7 10.1 ACE REN
21 pulmonary valve insufficiency 10.0 ACE REN
22 schizotypal personality disorder 10.0 ACE REN
23 clear cell adenocarcinoma 10.0 ACE REN
24 aorta angiosarcoma 10.0 ACE REN
25 deafness, autosomal recessive 79 10.0 ACE REN
26 paranasal sinus sarcoma 10.0 GGT1 REN
27 diastolic heart failure 10.0
28 acute necrotizing encephalitis 10.0 GGT1 REN
29 pyelonephritis 10.0 ACE REN
30 mixed germ cell-sex cord neoplasm 10.0 ACE REN
31 limb ischemia 10.0 ACE REN
32 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.0 ACE REN
33 diabetic encephalopathy 10.0 ACE REN
34 aphasia 10.0 ACE KCNMA1
35 gastrointestinal lymphoma 10.0 ACE REN
36 calcinosis 10.0 ACE REN
37 cervix small cell carcinoma 9.9 ACE REN
38 viral hepatitis 9.9 ACE KCNMA1
39 chronic myocardial ischemia 9.9 ACE REN
40 body dysmorphic disorder 9.9 ACE REN
41 peroneal neuropathy 9.9 ACE REN
42 critical limb ischemia 9.8 ACE REN
43 pheochromocytoma 9.6
44 renovascular hypertension 9.6
45 endotheliitis 9.6
46 hypothyroidism, congenital nongoitrous, 5 9.4 ACE GGT1 KCNMA1 KCNMB1 REN

Graphical network of the top 20 diseases related to Hypertension, Diastolic:



Diseases related to Hypertension, Diastolic

Symptoms & Phenotypes for Hypertension, Diastolic

Symptoms by clinical synopsis from OMIM:

608622

Clinical features from OMIM:

608622

Human phenotypes related to Hypertension, Diastolic:

32
id Description HPO Frequency HPO Source Accession
1 elevated diastolic blood pressure 32 HP:0005117

MGI Mouse Phenotypes related to Hypertension, Diastolic:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.35 GGT1 KCNMA1 KCNMB1 REN ACE
2 reproductive system MP:0005389 8.92 ACE GGT1 KCNMA1 REN

Drugs & Therapeutics for Hypertension, Diastolic

Drugs for Hypertension, Diastolic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 542)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Irbesartan Approved, Investigational Phase 4,Phase 3,Phase 2 138402-11-6 3749
2
Ramipril Approved Phase 4,Phase 3,Phase 2 87333-19-5 5362129
3
Bisoprolol Approved Phase 4,Phase 3,Phase 1,Phase 2 66722-44-9 2405
4
Carvedilol Approved, Investigational Phase 4,Phase 3 72956-09-3 2585
5
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
6
Amlodipine Approved Phase 4,Phase 3,Phase 2,Phase 1 88150-42-9 2162
7
Losartan Approved Phase 4,Phase 3,Phase 2,Phase 1 114798-26-4 3961
8
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
9
Nifedipine Approved Phase 4,Phase 3,Phase 2,Phase 1 21829-25-4 4485
10
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
11
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
12
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 58-93-5 3639
13
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
14
Latanoprost Approved, Investigational Phase 4,Phase 2 130209-82-4 5282380 5311221
15
Timolol Approved Phase 4 26839-75-8 33624 5478
16
Candesartan Approved Phase 4,Phase 3,Phase 2 139481-59-7 2541
17
Lercanidipine Approved, Investigational Phase 4,Phase 2 100427-26-7 65866
18
Atenolol Approved Phase 4,Phase 3,Phase 2 29122-68-7 2249
19
Felodipine Approved, Investigational Phase 4,Phase 3 72509-76-3 3333
20
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 37350-58-6, 51384-51-1 4171
21 Lacidipine Approved Phase 4,Phase 3 103890-78-4
22
Benazepril Approved, Investigational Phase 4,Phase 3 86541-75-5 5362124
23
Eprosartan Approved Phase 4,Phase 3 133040-01-4 5281037
24
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
25
Fosinopril Approved Phase 4 98048-97-6 55891
26
Lisinopril Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83915-83-7 5362119
27
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
28
Olmesartan Approved, Investigational Phase 4,Phase 3,Phase 2 144689-24-7, 144689-63-4 158781 130881
29
Perindopril Approved Phase 4,Phase 3 107133-36-8, 82834-16-0 107807
30
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
31
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
32
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
33
Telmisartan Approved, Investigational Phase 4,Phase 3,Phase 2 144701-48-4 65999
34
Trandolapril Approved Phase 4,Phase 3 87679-37-6 5484727
35
Carboprost Tromethamine Approved Phase 4 58551-69-2 5284525 45266502
36
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
37
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
38
Everolimus Approved Phase 4,Phase 2,Phase 3 159351-69-6 6442177
39
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
40
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2 128794-94-5 5281078
41
Mycophenolic acid Approved Phase 4,Phase 2 24280-93-1 446541
42
Pancrelipase Approved Phase 4 53608-75-6
43
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3 53123-88-9 5284616 6436030 46835353
44
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
45
Nebivolol Approved, Investigational Phase 4,Phase 3,Phase 1 152520-56-4, 99200-09-6, 118457-14-0 71301
46
Indapamide Approved Phase 4 26807-65-8 3702
47
Nitric Oxide Approved Phase 4,Phase 2,Phase 1 10102-43-9 145068
48
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
49
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
50
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666

Interventional clinical trials:

(show top 50) (show all 1177)
id Name Status NCT ID Phase
1 Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan Unknown status NCT00517322 Phase 4
2 Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study Unknown status NCT01243827 Phase 4
3 Safety and Efficacy of Ramipril in the Treatment of Essential Hypertension Unknown status NCT00366119 Phase 4
4 Addition of Spironolactone in Patients With Resistant Arterial Hypertension Unknown status NCT00524615 Phase 4
5 Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients Unknown status NCT00716950 Phase 4
6 A Study of Nifecardia SRFC and Adalat OROS in the Treatment of Patients With Essential Hypertension Unknown status NCT00173667 Phase 4
7 Aliskiren Versus Ramipril on Antiproteinuric Effect in Hypertensive, Type 2 Diabetic Patients With Microalbuminuria Unknown status NCT01038895 Phase 4
8 Efficacy Study of Nifedipine Controlled-Release Tablets (Xin Ran) to Treat Early Morning Blood Pressure and Central Arterial Pressure Unknown status NCT02357615 Phase 4
9 A Study on Ca Blocker Versus AII Antagonists in Hypertension With Type 2 Diabetes Unknown status NCT00144144 Phase 4
10 Treatment of HYpertension: Morning Versus Evening Unknown status NCT02214498 Phase 4
11 Effects of Cosopt on IOP and on Ocular Diastolic Perfusion Pressure Unknown status NCT00796198 Phase 4
12 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4
13 Effect of Active Telephone Calls in the Compliance of Hypertensive Patients With Treatment Unknown status NCT00813722 Phase 4
14 Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension Unknown status NCT01472796 Phase 4
15 Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status NCT01238705 Phase 4
16 Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive Patients Unknown status NCT00533858 Phase 4
17 Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics Unknown status NCT01715584 Phase 4
18 Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes Unknown status NCT00925119 Phase 4
19 Major Depressive Disorder - Understanding The Link Between The Brain And The Heart Unknown status NCT01568307 Phase 4
20 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4
21 The INDORSE Study: Inhibition of Dipeptidyl Peptidase IV: Outcomes on Renal Sodium Excretion Unknown status NCT02406443 Phase 4
22 Dexmedetomidine on Prevention of Side Effects of Hemabate Unknown status NCT02220361 Phase 4
23 A Study To Compare Sirolimus Versus Tacrolimus In De Novo Simultaneous Pancreas- Kidney Allograft Recipients Receiving An Induction Therapy With Antithymocyte Globulin Plus Mycophenolate Mofetil Plus Corticosteroids Unknown status NCT00693446 Phase 4
24 Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction Completed NCT02133352 Phase 4
25 Efficacy and Safety Study to Evaluate Combination Therapy With Nebivolol and Lisinopril vs. Placebo and Monotherapy in Patients With Stage 2 Diastolic Hypertension Completed NCT01218100 Phase 4
26 The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic Dysfunction Completed NCT00523549 Phase 4
27 To Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of the Heart to Fill and Empty, and the Ability of the Heart Muscle to Relax Adequately in People With High Blood Pressure. Completed NCT00170924 Phase 4
28 A Trial of Fimasartan for Early Diastolic Heart Failure Completed NCT01691118 Phase 4
29 Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart Completed NCT01961323 Phase 4
30 Telmisartan 80mg Plus Hydrochlorothiazide 25mg First Line in Moderate or Severe Hypertension Completed NCT00926289 Phase 4
31 Simvastatin and Diastolic Dysfunction Completed NCT01061450 Phase 4
32 A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM) Completed NCT02200640 Phase 4
33 A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® / LORZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM) Completed NCT02200653 Phase 4
34 Comparative Study of Valsartan and Amlodipine Versus Amlodipine Alone in Hypertension Completed NCT00333489 Phase 4
35 Ramipril - Hypertension Completed NCT00325806 Phase 4
36 Comparision of Blood Pressure Variability Between Amlodipine and Losartan Completed NCT01964079 Phase 4
37 Efficacy and Safety of Metoprolol Succinate Prolonged-Release Tablet in Patients With Mild to Moderate Hypertension Completed NCT00861016 Phase 4
38 A Randomized, Double-blind, Placebo Controlled Comparison of Telmisartan Hydrochlorothiazide (HCT) and Valsartan HCT in Hypertension (HTN) Stage I/II Patients Completed NCT00240448 Phase 4
39 Effectiveness of MICARDIS® (Telmisartan) on Blood Pressure Control and Quality of Live in Patients With Essential Hypertension Completed NCT02242370 Phase 4
40 Telmisartan vs. Valsartan in Patients With Mild to Moderate Hypertension Following a Missed Dose Completed NCT00034840 Phase 4
41 Effectiveness of a Valsartan Based vs an Amlodipine Based Treatment Strategy in naïve Patients With Stage 1 or Stage 2 Hypertension or in Patients Uncontrolled on Current Monotherapy Completed NCT00351130 Phase 4
42 Study of the Efficacy and Safety of Aliskiren HCTZ vs Ramipril in Obese Patients (BMI ≥ 30) With Stage 2 Hypertension Completed NCT00772577 Phase 4
43 Effects of Doxazosin Gastrointestinal Therapeutic System on Ambulatory Blood Pressure and Cardiovascular Risk Factors in Uncontrolled Hypertensive Patients Completed NCT00646841 Phase 4
44 STITCH (Simplified Therapeutic Intervention To Control Hypertension) Completed NCT00129909 Phase 4
45 Study to Evaluate Efficacy of Micardis® (Telmisartan) and Valsartan in Patients With Mild-to-moderate Hypertension After Missing One Dose Using Ambulatory Blood Pressure Monitoring Completed NCT02242318 Phase 4
46 Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension Completed NCT00277472 Phase 4
47 Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate Hypertension Completed NCT00765947 Phase 4
48 Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes Mellitus Completed NCT00787605 Phase 4
49 Efficacy and Safety of Once Daily Dosing of Aliskiren (300 mg (qd) Once a Day) to Twice Daily Dosing of Aliskiren (150 mg (Bid) Twice a Day) in Treating Moderate Hypertension. Completed NCT00654875 Phase 4
50 Prospective Randomised Investigation of the Safety and Efficacy of Micardis® vs Ramipril Using ABPM Completed NCT00274612 Phase 4

Search NIH Clinical Center for Hypertension, Diastolic

Genetic Tests for Hypertension, Diastolic

Genetic tests related to Hypertension, Diastolic:

id Genetic test Affiliating Genes
1 Hypertension, Diastolic, Resistance to 29

Anatomical Context for Hypertension, Diastolic

MalaCards organs/tissues related to Hypertension, Diastolic:

39
Heart, Endothelial

Publications for Hypertension, Diastolic

Articles related to Hypertension, Diastolic:

id Title Authors Year
1
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. ( 24759122 )
2014
2
An unusual case of hypertensive diastolic heart failure with bilateral subclavian artery stenosis. ( 19214295 )
2009
3
Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats. ( 18400557 )
2008
4
Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. ( 17932313 )
2007
5
Therapeutic effects of angiotensin II type 1 receptor blocker at an advanced stage of hypertensive diastolic heart failure. ( 17211254 )
2007
6
ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure. ( 15662228 )
2005
7
Ventricular volume and length in hypertensive diastolic heart failure. ( 16198882 )
2005
8
AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure. ( 14757777 )
2004
9
Regression of left ventricular hypertrophy in experimental renovascular hypertension: diastolic dysfunction depends more on myocardial collagen than it does on myocardial mass. ( 8986913 )
1996

Variations for Hypertension, Diastolic

ClinVar genetic disease variations for Hypertension, Diastolic:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 KCNMB1 NM_004137.3(KCNMB1): c.193G> A (p.Glu65Lys) single nucleotide variant protective rs11739136 GRCh37 Chromosome 5, 169810796: 169810796

Expression for Hypertension, Diastolic

Search GEO for disease gene expression data for Hypertension, Diastolic.

Pathways for Hypertension, Diastolic

Pathways related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.43 KCNMA1 KCNMB1
2
Show member pathways
11.06 ACE REN
3 10.61 ACE KCNMA1 REN
4
Show member pathways
10.58 KCNMA1 KCNMB1

GO Terms for Hypertension, Diastolic

Cellular components related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.35 ACE GGT1 KCNMA1 KCNMB1 REN
2 voltage-gated potassium channel complex GO:0008076 8.62 KCNMA1 KCNMB1

Biological processes related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.54 ACE GGT1 REN
2 potassium ion transport GO:0006813 9.43 KCNMA1 KCNMB1
3 potassium ion transmembrane transport GO:0071805 9.4 KCNMA1 KCNMB1
4 kidney development GO:0001822 9.32 ACE REN
5 regulation of blood pressure GO:0008217 9.26 ACE REN
6 response to calcium ion GO:0051592 9.16 KCNMA1 KCNMB1
7 beta-amyloid metabolic process GO:0050435 8.96 ACE REN
8 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.16 ACE REN
2 peptidase activity GO:0008233 9.13 ACE GGT1 REN
3 calcium-activated potassium channel activity GO:0015269 8.62 KCNMA1 KCNMB1

Sources for Hypertension, Diastolic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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