Aliases & Classifications for Hypertension, Diastolic

MalaCards integrated aliases for Hypertension, Diastolic:

Name: Hypertension, Diastolic 54
Hypertension, Diastolic, Resistance to 29 13
Diastolic Hypertension 52 69

Characteristics:

OMIM:

54
Inheritance:
autosomal dominant


HPO:

32
hypertension, diastolic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 608622
SNOMED-CT via HPO 65 263681008

Summaries for Hypertension, Diastolic

MalaCards based summary : Hypertension, Diastolic, also known as hypertension, diastolic, resistance to, is related to epithelial predominant pulmonary blastoma and synovial chondromatosis, and has symptoms including elevated diastolic blood pressure An important gene associated with Hypertension, Diastolic is KCNMB1 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1), and among its related pathways/superpathways are Renin secretion and Nitric oxide stimulates guanylate cyclase. The drugs Adenosine and Irbesartan have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial, and related phenotypes are cardiovascular system and muscle

Description from OMIM: 608622

Related Diseases for Hypertension, Diastolic

Diseases related to Hypertension, Diastolic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 epithelial predominant pulmonary blastoma 10.4 ACE NPPA
2 synovial chondromatosis 10.4 ACE NPPA
3 idiopathic juxtafoveal retinal telangiectasia 10.3 ACE NPPA
4 tumefactive multiple sclerosis 10.3 GGT1 NPPA
5 suppurative otitis media 10.3 ACE NPPA
6 repetitive stress injuries 10.3 NPPA REN
7 thoracic spinal canal and spinal cord meningioma 10.2 ACE NPPA
8 hypertrophic elongation of cervix 10.2 ACE GGT1
9 silver-russell syndrome due to 11p15 microduplication 10.2 NPPA REN
10 panuveitis 10.2 NPPA REN
11 urinary bladder posterior wall cancer 10.2 NPPA REN
12 hypothyroidism due to iodide transport defect 10.2 ACE REN
13 primary hyperoxaluria 10.2 ACE REN
14 acute liver failure 10.2 NPPA REN
15 mody, type ii 10.2 ACE REN
16 listeriosis 10.2 ACE REN
17 non-congenital cyst of kidney 10.2 ACE REN
18 voyeurism 10.1 ACE REN
19 adenocarcinoma 10.1 ACE REN
20 fibular aplasia ectrodactyly 10.1 ACE REN
21 broad ligament malignant neoplasm 10.1 ACE REN
22 cascade stomach 10.1 ACE REN
23 renal tubular dysgenesis 10.1 ACE REN
24 pulmonary valve insufficiency 10.1 ACE REN
25 microphthalmia, isolated, with coloboma 7 10.1 ACE REN
26 diastolic heart failure 10.1
27 cystinosis 10.1 ACE REN
28 congenital bilateral megacalycosis 10.1 ACE REN
29 chronic inflammatory demyelinating polyradiculoneuropathy 10.0 GGT1 REN
30 adams-oliver syndrome 5 10.0 ACE REN
31 pediatric angiosarcoma 10.0 ACE REN
32 paranasal sinus sarcoma 10.0 GGT1 REN
33 pyelonephritis 10.0 ACE REN
34 prostate neuroendocrine neoplasm 10.0 ACE REN
35 diabetic encephalopathy 10.0 ACE REN
36 periampullary adenoma 9.9 ACE REN
37 adult respiratory distress syndrome 9.9 ACE NPPA
38 munchausen by proxy 9.9 ACE KCNMA1
39 calcinosis 9.9 ACE REN
40 hypertrichosis 9.9 ACE REN
41 survival motor neuron spinal muscular atrophy 9.8 ACE REN
42 hypodontia of incisors and premolars 9.8 ACE NPPA REN
43 clitoris cancer 9.8 ACE NPPA REN
44 chylocele of tunica vaginalis 9.8 ACE NPPA REN
45 myopia 9.8 ACE NPPA REN
46 lymphadenitis 9.8 ACE NPPA REN
47 pyogenic arthritis, pyoderma gangrenosum and acne 9.8 ACE NPPA REN
48 renal clear cell carcinoma 9.8 ACE NPPA REN
49 craniosynostosis 7 9.8 ACE NPPA REN
50 craniosynostosis 9.8 ACE NPPA REN

Graphical network of the top 20 diseases related to Hypertension, Diastolic:



Diseases related to Hypertension, Diastolic

Symptoms & Phenotypes for Hypertension, Diastolic

Symptoms via clinical synopsis from OMIM:

54

Cardiovascular- Vascular:
resistance to moderate and severe diastolic hypertension


Clinical features from OMIM:

608622

Human phenotypes related to Hypertension, Diastolic:

32
id Description HPO Frequency HPO Source Accession
1 elevated diastolic blood pressure 32 HP:0005117

MGI Mouse Phenotypes related to Hypertension, Diastolic:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 ACE KCNMA1 KCNMB1 NPPA REN
2 muscle MP:0005369 9.26 KCNMA1 KCNMB1 NPPA REN
3 renal/urinary system MP:0005367 9.1 KCNMB1 NPPA REN ACE GGT1 KCNMA1

Drugs & Therapeutics for Hypertension, Diastolic

Drugs for Hypertension, Diastolic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 429)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational Phase 4 58-61-7 60961
2
Irbesartan Approved, Investigational Phase 4,Phase 3,Phase 2 138402-11-6 3749
3
Ramipril Approved Phase 4,Phase 3,Phase 2 87333-19-5 5362129
4
Bisoprolol Approved Phase 4,Phase 3,Phase 1,Phase 2 66722-44-9 2405
5
Carvedilol Approved, Investigational Phase 4,Phase 3 72956-09-3 2585
6
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
7
Amlodipine Approved Phase 4,Phase 3,Phase 2,Phase 1 88150-42-9 2162
8
Losartan Approved Phase 4,Phase 3,Phase 2,Phase 1 114798-26-4 3961
9
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
10
Nifedipine Approved Phase 4,Phase 3,Phase 2,Phase 1 21829-25-4 4485
11
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 75847-73-3 5362032 40466924
12
Enalaprilat Approved Phase 4,Phase 3,Phase 2,Phase 1 76420-72-9 6917719
13
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 58-93-5 3639
14
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
15
Latanoprost Approved, Investigational Phase 4,Phase 3 130209-82-4 5282380 5311221
16
Timolol Approved Phase 4,Phase 3 26839-75-8 33624 5478
17
Candesartan Approved Phase 4,Phase 3,Phase 2 139481-59-7 2541
18
Lercanidipine Approved, Investigational Phase 4,Phase 2 100427-26-7 65866
19
Atenolol Approved Phase 4,Phase 3,Phase 2 29122-68-7 2249
20
Felodipine Approved, Investigational Phase 4,Phase 3 72509-76-3 3333
21
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 1 37350-58-6, 51384-51-1 4171
22 Lacidipine Approved Phase 4,Phase 3 103890-78-4
23
Lisinopril Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83915-83-7, 76547-98-3 5362119
24
Nebivolol Approved, Investigational Phase 4,Phase 3,Phase 1 152520-56-4, 99200-09-6, 118457-14-0 71301
25
Indapamide Approved Phase 4 26807-65-8 3702
26
Telmisartan Approved, Investigational Phase 4,Phase 3,Phase 2 144701-48-4 65999
27
Nitric Oxide Approved Phase 4,Phase 2,Phase 1 10102-43-9 145068
28
Olmesartan Approved, Investigational Phase 4,Phase 3,Phase 2 144689-24-7, 144689-63-4 158781 130881
29
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
30
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
31
Eprosartan Approved Phase 4,Phase 3 133040-01-4 5281037
32
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
33
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
34
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
35
Doxazosin Approved Phase 4 74191-85-8 3157
36
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
37
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
38
Amiloride Approved Phase 4,Phase 3 2016-88-8, 2609-46-3 16231
39
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
40
Clonidine Approved Phase 4,Phase 1 4205-90-7 2803
41
Furosemide Approved, Vet_approved Phase 4,Phase 3 54-31-9 3440
42
Benazepril Approved, Investigational Phase 4,Phase 3 86541-75-5 5362124
43
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
44
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
45
Ibuprofen Approved Phase 4 15687-27-1 3672
46
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
47
Perindopril Approved Phase 4,Phase 3 107133-36-8, 82834-16-0 107807
48
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
49
Levobupivacaine Approved Phase 4 27262-47-1 92253
50
Liraglutide Approved Phase 4 204656-20-2 44147092

Interventional clinical trials:

(show top 50) (show all 1077)

id Name Status NCT ID Phase Drugs
1 Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Tria Unknown status NCT01918111 Phase 4 adenosine infusion treatment
2 Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan Unknown status NCT00517322 Phase 4 ramipril;irbesartan
3 Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study Unknown status NCT01243827 Phase 4 carvedilol;bisoprolol
4 Safety and Efficacy of Ramipril in the Treatment of Essential Hypertension Unknown status NCT00366119 Phase 4 Ramipril
5 Addition of Spironolactone in Patients With Resistant Arterial Hypertension Unknown status NCT00524615 Phase 4 spironolactone
6 Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients Unknown status NCT00716950 Phase 4 valsartan/amlodpine;losartan/amlodpine
7 A Study of Nifecardia SRFC and Adalat OROS in the Treatment of Patients With Essential Hypertension Unknown status NCT00173667 Phase 4 Nifedipine 30 mg GITS
8 Aliskiren Versus Ramipril on Antiproteinuric Effect in Hypertensive, Type 2 Diabetic Patients With Microalbuminuria Unknown status NCT01038895 Phase 4 Ramipril;Experimental
9 Efficacy Study of Nifedipine Controlled-Release Tablets (Xin Ran) to Treat Early Morning Blood Pressure and Central Arterial Pressure Unknown status NCT02357615 Phase 4 nifedipine CR tablets (Xin Ran);Adalat
10 A Study on Ca Blocker Versus AII Antagonists in Hypertension With Type 2 Diabetes Unknown status NCT00144144 Phase 4 Angiotensin II receptor antagonists, Calcium channel blocker
11 Treatment of HYpertension: Morning Versus Evening Unknown status NCT02214498 Phase 4 Enalapril/hydrochlorothiazide;Placebo
12 Effects of Cosopt on IOP and on Ocular Diastolic Perfusion Pressure Unknown status NCT00796198 Phase 4 Xalatan+Cosopt;Xalatan
13 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4 candesartan;lercanidipine
14 Effect of Active Telephone Calls in the Compliance of Hypertensive Patients With Treatment Unknown status NCT00813722 Phase 4 amlodipine (calcium chanel blocker) and losartan (at1 antagonist);atenolol (beta blocker) and hydrochlorothiazide (diuretic)
15 Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension Unknown status NCT01472796 Phase 4 Tekturna(Aliskiren) plus placebo
16 Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status NCT01238705 Phase 4 Felodipine add Irbesartan;Felodipine add Metoprolol
17 Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive Patients Unknown status NCT00533858 Phase 4 lacidipine (4 mg) or losartan (50 mg)
18 Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes Unknown status NCT00925119 Phase 4 Atenolol
19 Major Depressive Disorder - Understanding The Link Between The Brain And The Heart Unknown status NCT01568307 Phase 4 Participants will be prescribed an approved selective serotonin re-uptake inhibitor (SSRI) antidepressant.
20 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
21 Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction Completed NCT02133352 Phase 4 Ranolazine
22 Efficacy and Safety Study to Evaluate Combination Therapy With Nebivolol and Lisinopril vs. Placebo and Monotherapy in Patients With Stage 2 Diastolic Hypertension Completed NCT01218100 Phase 4 nebivolol and lisinopril (free combination);nebivolol monotherapy;lisinopril monotherapy;placebo
23 The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic Dysfunction Completed NCT00523549 Phase 4 valsartan;amlodipine
24 To Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of the Heart to Fill and Empty, and the Ability of the Heart Muscle to Relax Adequately in People With High Blood Pressure. Completed NCT00170924 Phase 4 Valsartan
25 A Trial of Fimasartan for Early Diastolic Heart Failure Completed NCT01691118 Phase 4 Fimasartan;Antihypertensive treatment
26 Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart Completed NCT01961323 Phase 4 Nebivolol
27 Telmisartan 80mg Plus Hydrochlorothiazide 25mg First Line in Moderate or Severe Hypertension Completed NCT00926289 Phase 4 Telmisartan;Telmisartan;Hydrochlorothiazide
28 Simvastatin and Diastolic Dysfunction Completed NCT01061450 Phase 4 Simvastatin;Placebo
29 A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM) Completed NCT02200640 Phase 4 High dose of Micardis®, once daily;Low dose of Micardis®, once daily;Low dose of COZAAR®, once daily;High dose of COZAAR®, once daily;Placebo
30 A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® / LORZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM) Completed NCT02200653 Phase 4 High dose of MICARDIS®, once daily;Low dose of MICARDIS®, once daily;Low dose of COZAAR® / LORZAAR®, once daily;High dose of COZAAR® / LORZAAR®, once daily;Placebo
31 Comparative Study of Valsartan and Amlodipine Versus Amlodipine Alone in Hypertension Completed NCT00333489 Phase 4 valsartan
32 Ramipril - Hypertension Completed NCT00325806 Phase 4 Ramipril
33 Comparision of Blood Pressure Variability Between Amlodipine and Losartan Completed NCT01964079 Phase 4 Amlodipine;Losartan
34 Efficacy and Safety of Metoprolol Succinate Prolonged-Release Tablet in Patients With Mild to Moderate Hypertension Completed NCT00861016 Phase 4 metoprolol succinate prolonged-release tablet and felodipine
35 A Randomized, Double-blind, Placebo Controlled Comparison of Telmisartan Hydrochlorothiazide (HCT) and Valsartan HCT in Hypertension (HTN) Stage I/II Patients Completed NCT00240448 Phase 4 telmisartan 80 mg/hydrochlorothiazide 25 mg;valsartan 160 mg/hydrochlorothiazide 25 mg;placebo
36 Effectiveness of MICARDIS® (Telmisartan) on Blood Pressure Control and Quality of Live in Patients With Essential Hypertension Completed NCT02242370 Phase 4 Low dose of telmisartan;High dose of telmisartan
37 Telmisartan vs. Valsartan in Patients With Mild to Moderate Hypertension Following a Missed Dose Completed NCT00034840 Phase 4 telmisartan, valsartan
38 Effectiveness of a Valsartan Based vs an Amlodipine Based Treatment Strategy in naïve Patients With Stage 1 or Stage 2 Hypertension or in Patients Uncontrolled on Current Monotherapy Completed NCT00351130 Phase 4 valsartan;amlodipine
39 Study of the Efficacy and Safety of Aliskiren HCTZ vs Ramipril in Obese Patients (BMI ≥ 30) With Stage 2 Hypertension Completed NCT00772577 Phase 4 Aliskiren Hydrochlorothiazide;Ramipril
40 Effects of Doxazosin Gastrointestinal Therapeutic System on Ambulatory Blood Pressure and Cardiovascular Risk Factors in Uncontrolled Hypertensive Patients Completed NCT00646841 Phase 4 Doxazosin gastrointestinal therapeutic system (GITS)
41 STITCH (Simplified Therapeutic Intervention To Control Hypertension) Completed NCT00129909 Phase 4 fixed dose combination therapy
42 Study to Evaluate Efficacy of Micardis® (Telmisartan) and Valsartan in Patients With Mild-to-moderate Hypertension After Missing One Dose Using Ambulatory Blood Pressure Monitoring Completed NCT02242318 Phase 4 Telmisartan;Valsartan;Placebo
43 Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension Completed NCT00277472 Phase 4 Valsartan/Hydrochlorothiazide;HCTZ
44 Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate Hypertension Completed NCT00765947 Phase 4 Aliskiren;Hydrochlorothiazide;Amlodipine
45 Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes Mellitus Completed NCT00787605 Phase 4 Amlodipine;Hydrochlorothiazide (HCTZ);Aliskiren
46 Efficacy and Safety of Once Daily Dosing of Aliskiren (300 mg (qd) Once a Day) to Twice Daily Dosing of Aliskiren (150 mg (Bid) Twice a Day) in Treating Moderate Hypertension. Completed NCT00654875 Phase 4 Aliskiren;Placebo to Aliskiren
47 Prospective Randomised Investigation of the Safety and Efficacy of Micardis® vs Ramipril Using ABPM Completed NCT00274612 Phase 4 Telmisartan;Ramipril
48 Irbesartan in Hypertension Completed NCT00265967 Phase 4 Irbesartan
49 A Study of Safety and Efficacy in MK-0954A Combination in Participants With Hypertension (MK-0954A-373 AM3) Completed NCT01431508 Phase 4 Losartan 50 mg / HCTZ 12.5 mg
50 A Study to Evaluate the Efficacy and Safety of Quinapril or Quinapril Plus Hydrochlorothiazide in Patients With Mild to Moderate Hypertension Completed NCT00651287 Phase 4 quinapril 20 mg;quinapril 20 mg plus hydrochlorothiazide 12.5 mg;quinapril 40 mg

Search NIH Clinical Center for Hypertension, Diastolic

Genetic Tests for Hypertension, Diastolic

Genetic tests related to Hypertension, Diastolic:

id Genetic test Affiliating Genes
1 Hypertension, Diastolic, Resistance to 29

Anatomical Context for Hypertension, Diastolic

MalaCards organs/tissues related to Hypertension, Diastolic:

39
Heart, Kidney, Endothelial, Testes, Lung, Brain, Liver

Publications for Hypertension, Diastolic

Articles related to Hypertension, Diastolic:

id Title Authors Year
1
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. ( 24759122 )
2014
2
An unusual case of hypertensive diastolic heart failure with bilateral subclavian artery stenosis. ( 19214295 )
2009
3
Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats. ( 18400557 )
2008
4
Therapeutic effects of angiotensin II type 1 receptor blocker at an advanced stage of hypertensive diastolic heart failure. ( 17211254 )
2007
5
Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. ( 17932313 )
2007
6
Ventricular volume and length in hypertensive diastolic heart failure. ( 16198882 )
2005
7
ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure. ( 15662228 )
2005
8
AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure. ( 14757777 )
2004
9
Regression of left ventricular hypertrophy in experimental renovascular hypertension: diastolic dysfunction depends more on myocardial collagen than it does on myocardial mass. ( 8986913 )
1996

Variations for Hypertension, Diastolic

ClinVar genetic disease variations for Hypertension, Diastolic:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 KCNMB1 NM_004137.3(KCNMB1): c.193G> A (p.Glu65Lys) single nucleotide variant protective rs11739136 GRCh37 Chromosome 5, 169810796: 169810796

Expression for Hypertension, Diastolic

Search GEO for disease gene expression data for Hypertension, Diastolic.

Pathways for Hypertension, Diastolic

Pathways related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.61 ACE KCNMA1 REN
2
Show member pathways
10.58 KCNMA1 KCNMB1

GO Terms for Hypertension, Diastolic

Cellular components related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 8.62 KCNMA1 KCNMB1

Biological processes related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.32 ACE REN
2 response to calcium ion GO:0051592 9.26 KCNMA1 KCNMB1
3 beta-amyloid metabolic process GO:0050435 9.16 ACE REN
4 angiotensin maturation GO:0002003 8.96 ACE REN
5 regulation of blood pressure GO:0008217 8.8 ACE NPPA REN

Molecular functions related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.33 ACE GGT1 REN
2 endopeptidase activity GO:0004175 8.96 ACE REN
3 calcium-activated potassium channel activity GO:0015269 8.62 KCNMA1 KCNMB1

Sources for Hypertension, Diastolic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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