Hypertension, Early-onset, Autosomal Dominant, with Exacerbation in Pregnancy malady

MalaCards: Hypertension, Early-onset, Autosomal Dominant, with Exacerbation in Pregnancy, also known as hypertensive disease, is related to hypertension, diastolic, resistance to and hypertension, salt-resistant. An important gene associated with Hypertension, Early-onset, Autosomal Dominant, with Exacerbation in Pregnancy is NR3C2 (nuclear receptor subfamily 3, group C, member 2). The drugs bendroflumethiazide and diltiazem have been mentioned in the context of this disorder.

OMIM: 605115

hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 33 hypertensive disease 43

Diseases related to hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	hypertension, diastolic, resistance to	5.2
2	hypertension, salt-resistant	5.2
3	malignant hypertension	5.2
4	portal hypertension	5.2
5	renal hypertension	5.2
6	renovascular hypertension	5.2
7	hypertension with brachydactyly	5.2
8	hypertensive hypokalemia familial	5.2

Clinical features from OMIM: 605115

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 [cv490] antihypertensives,other, acebutolol, acebutolol hydrochloride, amiloride, amiloride hydrochloride, amlodipine, amlodipine besylate, atenolol, benazepril, benazepril hydrochloride, bendroflumethiazide, benzthiazide, bepridil, bepridil hydrochloride, betaxolol, betaxolol hydrochloride, bisoprolol, bisoprolol fumarate, bumetanide, candesartan, candesartan cilexetil, carteolol, carteolol hydrochloride, carvedilol, carvedilol phosphate, chlorothiazide, chlorothiazide sodium, chlorthalidone, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, coenzyme q10, cyclothiazide, deserpidine, diltiazem, diltiazem hcl, diltiazem hydrochloride, diltiazem maleate, ditiaz, dong quai, doxazosin, doxazosin mesylate, eplerenone, eprosartan, eprosartan mesylate, esmolol, esmolol hydrochloride, ethacrynate sodium, ethacrynic acid, felodipine, fish oil, fosinopril, fosinopril sodium, furosemide, garlic oil, guanabenz, guanabenz acetate, guanadrel, guanadrel sulfate, guanethidine, guanethidine monosulfate, guanfacine, guanfacine hydrochloride, hydrochlorothiazide, hydroflumethiazide, indapamide, irbesartan, isradipine, lisinopril, losartan, losartan potassium, methyclothiazide, methyldopa, methyldopate hydrochloride, metolazone, metoprolol, metoprolol succinate, metoprolol tartrate, mibefradil, mibefradil dihydrochloride, moexipril, moexipril hydrochloride, nadolol, nicardipine, nicardipine hydrochloride, nifedipine, nisoldipine, olmesartan, olmesartan medoxomil, penbutolol, penbutolol sulfate, perindopril, perindopril erbumine, pindolol, polythiazide, prazosin, prazosin hydrochloride, propranolol, propranolol hydrochloride, quinapril, quinapril hydrochloride, quinethazone, ramipril, reserpine, spironolactone, spironolactone pwdr [va product], telmisartan, terazosin, terazosin hydrochloride, timolol, timolol hemihydrate, timolol maleate, torsemide, trandolapril, triamterene, trichlormethiazide, valsartan, verapamil, verapamil hydrochloride

Genes related to hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.1	Disorders