MCID: HYP595
MIFTS: 66

Hypertension, Essential malady

Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases categories

Summaries for Hypertension, Essential

About this section


MedlinePlus:32 Blood pressure is the force of your blood pushing against the walls of your arteries. each time your heart beats, it pumps blood into the arteries. your blood pressure is highest when your heart beats, pumping the blood. this is called systolic pressure. when your heart is at rest, between beats, your blood pressure falls. this is called diastolic pressure. your blood pressure reading uses these two numbers. usually the systolic number comes before or above the diastolic number. a reading of 119/79 or lower is normal blood pressure 140/90 or higher is high blood pressure between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. high blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. you can control high blood pressure through healthy lifestyle habits and taking medicines, if needed. nih: national heart, lung, and blood institute

MalaCards based summary: Hypertension, Essential, also known as hypertension, is related to portal hypertension and pulmonary hypertension, and has symptoms including multifactorial inheritance, elevated systolic blood pressure and elevated mean arterial pressure. An important gene associated with Hypertension, Essential is AGTR1 (angiotensin II receptor, type 1), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Gastrin-CREB signalling pathway via PKC and MAPK. The drugs acebutolol and amiloride and the compounds perindopril and candesartan have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related mouse phenotype renal/urinary system.

Disease Ontology:9 A hypertension with no known cause. it is the most common type of hypertension.

CDC:3 About 1 of 3 U.S. adults—or about 70 million people—have high blood pressure.1Only about half (52%) of these people have their high blood pressure under control.1 This common condition increases the risk for heart disease and stroke, 2 of the leading causes of death for Americans.2Get more quick facts about high blood pressure, or learn more about high blood pressure in the United States.

OMIM:45 The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple... (145500) more...

Wikipedia:63 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

Aliases & Classifications for Hypertension, Essential

About this section

Hypertension, Essential, Aliases & Descriptions:

Name: Hypertension, Essential 45 10
Hypertension 45 30 9 11 3
Essential Hypertension 9 43 22 60
High Blood Pressure 9 32 3
Hypertension, Essential, Susceptibility to, 2 10
Hypertension, Essential, Susceptibility to, 6 10
Hypertension, Essential, Susceptibility to, 3 10
Hypertension, Essential, Susceptibility to, 1 10
Hypertension, Essential, Susceptibility to, 4 10
Hypertension, Essential, Susceptibility to, 5 10
Hypertension, Essential, Salt-Sensitive 45
Hypertension, Salt-Sensitive Essential 45
 
Vascular Hypertensive Disorder 9
Hypertension, Essential 2 45
Hypertension, Essential 3 45
Hypertension, Essential 4 45
Hypertension, Essential 6 45
Hypertension, Essential 1 45
Hypertension, Essential 5 45
Idiopathic Hypertension 9
Primary Hypertension 9
Hypertensive Disease 60
Hyperpiesia 9
Htn 9


Classifications:



Related Diseases for Hypertension, Essential

About this section

Diseases in the Familial Hypertension family:

hypertension, essential Benign Essential Hypertension
Malignant Essential Hypertension Benign Secondary Hypertension
Malignant Hypertension Malignant Secondary Hypertension

Diseases related to Hypertension, Essential via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1330)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension32.1NOS3, AGTR1
2pulmonary hypertension31.3PTGIS, NOS2, ECE1, AGT, NOS3
3kidney disease31.2AGT, AGTR1, NOS3
4congenital heart disease31.1NOS3, AGTR1, AGT
5proteinuria30.8NOS3, AGTR1, GNB3, ADD1, AGT
6gitelman syndrome30.6AGT
7coronary artery disease30.5AGTR1, AGT, NOS3, NOS2
8vascular disease30.4NOS3, AGT, AGTR1, PTGIS, NOS2
9hyperinsulinism30.4NOS3, AGT, AGTR1
10vesicoureteral reflux30.3AGT, AGTR1
11iga glomerulonephritis30.2AGTR1, AGT, ADD1
12renal fibrosis30.1AGT, AGTR1
13glomerulosclerosis30.1NOS2, AGTR1, AGT
14noonan syndrome 130.1AGTR1, ECE1, AGT
15ischemia30.1ECE1, PTGIS, NOS2, NOS3, AGT
16renal tubular dysgenesis30.0AGTR1, AGT
17hyperglycemia30.0NOS2, NOS3, AGT, AGTR1
18myocardial infarction29.9ECE1, AGTR1, AGT, NOS3, ADD1, PTGIS
19preeclampsia/eclampsia 129.9ECE1, NOS2, AGT, AGTR1, NOS3
20adenoma29.9PTGIS, CYP3A5, GNB3, ECE1
21impotence29.7NOS3, NOS2
22focal segmental glomerulosclerosis29.7NOS2, AGTR1
23chronic kidney failure29.7AGTR1, AGT, NOS3, GNB3
24atherosclerosis29.6AGT, AGTR1, NOS2, NOS3, ADD1, PTGIS
25diabetes mellitus, noninsulin-dependent29.5AGTR1, AGT, NOS3, GNB3
26intracranial hypertension11.1
27renovascular hypertension11.1
28malignant hypertension11.0
29ocular hypertension11.0
30renal hypertension11.0
31chronic thromboembolic pulmonary hypertension11.0
32endotheliitis11.0
33hypertensive heart disease11.0
34obesity10.9
35hypertensive encephalopathy10.9
36open-angle glaucoma10.8
37hypertensive retinopathy10.8
38cerebritis10.8
39neurogenic hypertension10.7
40nephrosclerosis10.7
41hepatitis10.7
42retinitis10.7
43pediatric hypertension10.7
44blindness10.6
45connective tissue disease10.6
46eclampsia10.6
47pre-eclampsia10.6
48hyperaldosteronism10.6
49artery disease10.6
50aneurysm10.6

Graphical network of the top 20 diseases related to Hypertension, Essential:



Diseases related to hypertension, essential

Symptoms for Hypertension, Essential

About this section

Symptoms by clinical synopsis from OMIM:

145500

Clinical features from OMIM:

145500

HPO human phenotypes related to Hypertension, Essential:

id Description Frequency HPO Source Accession
1 multifactorial inheritance HP:0001426
2 elevated systolic blood pressure HP:0004421
3 elevated mean arterial pressure HP:0004972
4 elevated diastolic blood pressure HP:0005117

Drugs & Therapeutics for Hypertension, Essential

About this section

Drug clinical trials:

Search ClinicalTrials for Hypertension, Essential

Search NIH Clinical Center for Hypertension, Essential

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hypertension, Essential

About this section

Genetic tests related to Hypertension, Essential:

id Genetic test Affiliating Genes
1 Essential Hypertension22

Anatomical Context for Hypertension, Essential

About this section

MalaCards organs/tissues related to Hypertension, Essential:

31
Heart, Kidney, Lung

Animal Models for Hypertension, Essential or affiliated genes

About this section

MGI Mouse Phenotypes related to Hypertension, Essential:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1AGTR1, AGT, NOS3, NOS2, PTGIS

Publications for Hypertension, Essential

About this section

Variations for Hypertension, Essential

About this section

Clinvar genetic disease variations for Hypertension, Essential:

6
id Gene Variation Type Significance SNP ID Assembly Location
1PTGISPTGIS, IVS9, T-C, +2single nucleotide variantPathogenic

Expression for genes affiliated with Hypertension, Essential

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Hypertension, Essential patients vs. healthy controls: 30 (show all 9)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1C12orf29chromosome 12 open reading frame 29Blood+3.240.000
2ATF1activating transcription factor 1Blood+3.230.000
3PIKFYVEphosphoinositide kinase, FYVE finger containingBlood+3.180.000
4EID1EP300 interacting inhibitor of differentiation 1Blood+3.080.000
5STAM2signal transducing adaptor molecule (SH3 domain and ITAM motif) 2Blood+3.070.000
6SPASTspastinBlood+3.070.000
7UFL1UFM1-specific ligase 1Blood+3.020.000
8SUB1SUB1 homolog (S. cerevisiae)Blood+3.000.000
9ANKRD12ankyrin repeat domain 12Blood+3.000.000

Search GEO for disease gene expression data for Hypertension, Essential.

Pathways for genes affiliated with Hypertension, Essential

About this section

Pathways related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8AGTR1, AGT, NOS3
2
Show member pathways
9.8AGTR1, AGT, GNB3
39.7NOS2, NOS3
4
Show member pathways
9.7NOS2, NOS3
5
Show member pathways
9.7NOS2, NOS3
69.7NOS3, NOS2
7
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis36
9.7NOS3, NOS2
89.7NOS3, GNB3, ECE1
9
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.5NOS2, NOS3, AGTR1
109.5AGTR1, NOS3, NOS2
11
Show member pathways
9.5GNB3, NOS2, NOS3
12
Show member pathways
8.1CYP3A5, GNB3, PTGIS, ACSM3, NOS2, NOS3

Compounds for genes affiliated with Hypertension, Essential

About this section

Compounds related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1perindopril43 49 1212.3NOS3, AGT, AGTR1
2candesartan43 49 28 1213.2AGTR1, NOS3, AGT
3diuretics4910.2NOS3, ADD1
4atenolol43 49 28 24 1214.2AGT, AGTR1, GNB3
5thiazide4310.2AGTR1, GNB3, ADD1
6diltiazem43 28 49 1213.2AGTR1, AGT, CYP3A5
7cv 119744310.2AGTR1, AGT
8magnesium lithospermate b4310.1NOS3, NOS2
9n-(3-(aminomethyl)benzyl)acetamidine43 1211.1NOS3, NOS2
10n5-(1-iminoethyl)-l-ornithine4310.1NOS2, NOS3
11cgp42112a4310.1AGT, AGTR1
12l-thiocitrulline43 1211.1NOS2, NOS3
13nitrit4310.0NOS2, NOS3
14furosemide43 59 28 49 24 1215.0GNB3, AGTR1, ADD1
15s-ethylisothiourea43 1211.0NOS3, NOS2
16hydrochlorothiazide43 28 49 24 1214.0AGTR1, AGT, ADD1, GNB3
17amlodipine43 49 24 1213.0CYP3A5, AGT, NOS3, AGTR1
18captopril43 59 49 28 1214.0AGTR1, AGT, ECE1
19clonidine43 49 28 1213.0GNB3, CYP3A5, NOS3, AGTR1
20aminoguanidine43 28 1212.0AGTR1, NOS3, NOS2
21simvastatin43 49 59 28 24 1214.9AGTR1, CYP3A5, NOS3, AGT
22n(g)-nitro-l-arginine methyl ester439.9NOS2, NOS3, AGT
23onoo439.9NOS3, NOS2, PTGIS
24ng-nitro-l-arginine439.9AGT, NOS2, NOS3
257-nitroindazole43 1210.9NOS2, NOS3
26apocynin43 5910.9NOS3, NOS2, AGT
27n(g)-hydroxy-l-arginine439.9NOS2, NOS3
28rosuvastatin43 49 28 1212.8CYP3A5, NOS2, NOS3
29cerivastatin49 43 28 1212.8CYP3A5, NOS3, NOS2
303-bromo-7-nitroindazole59 1210.8NOS3, NOS2
31nitrate439.8PTGIS, NOS3, NOS2
32ang ii439.8NOS2, NOS3, AGT, AGTR1
33l-nmma439.8AGTR1, NOS2, NOS3, AGT
34phenylephrine43 28 24 1212.7AGTR1, AGT, NOS3, NOS2
35guanylate439.7NOS3, AGT, AGTR1, NOS2
36fluvastatin43 49 28 1212.7NOS2, CYP3A5, NOS3, AGTR1
37cgmp43 2810.7NOS2, NOS3, AGT, AGTR1
38sildenafil28 43 49 24 1213.7CYP3A5, NOS2, GNB3, NOS3
39sodium43 2410.6GNB3, ADD1, CYP3A5, AGTR1, AGT
40imidazole439.5AGTR1, NOS3, NOS2
41heme28 24 1211.5PTGIS, NOS2, NOS3, CYP3A5
42nitroglycerin43 1210.5GNB3, NOS3, PTGIS, NOS2, AGTR1
43cholesterol43 28 24 1212.5ADD1, PTGIS, AGTR1, ECE1, AGT, GNB3
44actinomycin d439.4NOS2, AGTR1, NOS3, ECE1, AGT
45nadph43 2410.4NOS2, AGT, AGTR1, NOS3, CYP3A5
46superoxide43 2410.4PTGIS, NOS2, NOS3, AGT, AGTR1
47prostacyclin439.2NOS3, AGTR1, AGT, NOS2, PTGIS, ECE1
48diphenyleneiodonium439.2NOS2, NOS3, AGT
49nitric oxide43 24 1210.8AGT, ECE1, GNB3, PTGIS, ADD1, NOS2
50oxygen43 249.7AGTR1, AGT, NOS3, NOS2, PTGIS, CYP3A5

GO Terms for genes affiliated with Hypertension, Essential

About this section

Biological processes related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:003386410.4AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:000203410.4AGT, AGTR1
3regulation of renal sodium excretionGO:003581310.4AGT, AGTR1
4renin-angiotensin regulation of aldosterone productionGO:000201810.4AGT, AGTR1
5positive regulation of cholesterol esterificationGO:001087310.3AGTR1, AGT
6low-density lipoprotein particle remodelingGO:003437410.3AGT, AGTR1
7regulation of systemic arterial blood pressure by endothelinGO:000310010.3ECE1, NOS3
8positive regulation of cellular protein metabolic processGO:003227010.2AGTR1, AGT
9positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGTR1, AGT
10regulation of vasoconstrictionGO:001922910.1AGTR1, AGT, ECE1
11positive regulation of angiogenesisGO:004576610.0NOS3, ADD1, PTGIS
12positive regulation of guanylate cyclase activityGO:003128410.0NOS2, NOS3
13arginine catabolic processGO:000652710.0NOS2, NOS3
14positive regulation of reactive oxygen species metabolic processGO:0200037910.0AGT, AGTR1
15nitric oxide biosynthetic processGO:00068099.9NOS3, NOS2
16nitric oxide mediated signal transductionGO:00072639.9AGT, NOS3, NOS2
17negative regulation of blood pressureGO:00457769.7NOS3, NOS2
18interaction with hostGO:00517019.7NOS3, NOS2
19regulation of blood pressureGO:00082179.7NOS3, ACSM3, GNB3
20regulation of cell proliferationGO:00421279.7NOS2, AGT, AGTR1
21positive regulation of vasodilationGO:00459099.4NOS2, NOS3

Molecular functions related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:000449710.0PTGIS, CYP3A5
2nitric-oxide synthase activityGO:00045179.9NOS3, NOS2
3arginine bindingGO:00346189.8NOS2, NOS3
4tetrahydrobiopterin bindingGO:00346179.8NOS2, NOS3
5NADPH-hemoprotein reductase activityGO:00039589.7NOS3, NOS2
6FMN bindingGO:00101819.6NOS2, NOS3
7heme bindingGO:00200379.4NOS3, NOS2, PTGIS, CYP3A5
8iron ion bindingGO:00055069.4CYP3A5, PTGIS, NOS2, NOS3
9calmodulin bindingGO:00055169.2NOS3, NOS2, ADD1

Products for genes affiliated with Hypertension, Essential

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hypertension, Essential

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet