Hypertension, Essential malady

Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Hypertension, Essential

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Aliases & Descriptions for Hypertension, Essential:

Name: Hypertension, Essential 46 9
Hypertension 46 30 8 10 2
Essential Hypertension 8 44 22 61
High Blood Pressure 8 32 2
Hypertension, Essential, Susceptibility to, 2 9
Hypertension, Essential, Susceptibility to, 6 9
Hypertension, Essential, Susceptibility to, 3 9
Hypertension, Essential, Susceptibility to, 1 9
Hypertension, Essential, Susceptibility to, 4 9
Hypertension, Essential, Susceptibility to, 5 9
Hypertension, Essential, Salt-Sensitive 46
Hypertension, Salt-Sensitive Essential 46
Vascular Hypertensive Disorder 8
Hypertension, Essential 2 46
Hypertension, Essential 3 46
Hypertension, Essential 4 46
Hypertension, Essential 6 46
Hypertension, Essential 1 46
Hypertension, Essential 5 46
Idiopathic Hypertension 8
Primary Hypertension 8
Hypertensive Disease 61
Hyperpiesia 8
Htn 8


Summaries for Hypertension, Essential

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MedlinePlus:32 Blood pressure is the force of your blood pushing against the walls of your arteries. each time your heart beats, it pumps blood into the arteries. your blood pressure is highest when your heart beats, pumping the blood. this is called systolic pressure. when your heart is at rest, between beats, your blood pressure falls. this is called diastolic pressure. your blood pressure reading uses these two numbers. usually the systolic number comes before or above the diastolic number. a reading of 119/79 or lower is normal blood pressure 140/90 or higher is high blood pressure between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. high blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. you can control high blood pressure through healthy lifestyle habits and taking medicines, if needed. nih: national heart, lung, and blood institute

MalaCards based summary: Hypertension, Essential, also known as hypertension, is related to portal hypertension and pulmonary hypertension, and has symptoms including multifactorial inheritance, elevated systolic blood pressure and elevated mean arterial pressure. An important gene associated with Hypertension, Essential is AGTR1 (angiotensin II receptor, type 1), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Gastrin-CREB signalling pathway via PKC and MAPK. The drugs acebutolol and amiloride and the compounds perindopril and candesartan have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related mouse phenotype renal/urinary system.

Disease Ontology:8 A hypertension with no known cause. it is the most common type of hypertension.

CDC:2 About 1 of 3 U.S. adults—or about 70 million people—have high blood pressure.1Only about half (52%) of these people have their high blood pressure under control.1 This common condition increases the risk for heart disease and stroke, 2 of the leading causes of death for Americans.2Get more quick facts about high blood pressure, or learn more about high blood pressure in the United States.

OMIM:46 The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple... (145500) more...

Wikipedia:64 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

Related Diseases for Hypertension, Essential

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Diseases in the Familial Hypertension family:

hypertension, essential Benign Essential Hypertension
Malignant Essential Hypertension Benign Secondary Hypertension
Malignant Hypertension Malignant Secondary Hypertension

Diseases related to Hypertension, Essential via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1330)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension32.1NOS3, AGTR1
2pulmonary hypertension31.3PTGIS, NOS2, ECE1, AGT, NOS3
3kidney disease31.2AGT, AGTR1, NOS3
4congenital heart disease31.1NOS3, AGTR1, AGT
5proteinuria30.8NOS3, AGTR1, GNB3, ADD1, AGT
6gitelman syndrome30.6AGT
7coronary artery disease30.5AGTR1, AGT, NOS3, NOS2
8vascular disease30.4NOS3, AGT, AGTR1, PTGIS, NOS2
9hyperinsulinism30.4NOS3, AGT, AGTR1
10vesicoureteral reflux30.3AGT, AGTR1
11iga glomerulonephritis30.2AGTR1, AGT, ADD1
12renal fibrosis30.1AGT, AGTR1
13glomerulosclerosis30.1NOS2, AGTR1, AGT
14noonan syndrome 130.1AGTR1, ECE1, AGT
15ischemia30.1ECE1, PTGIS, NOS2, NOS3, AGT
16renal tubular dysgenesis30.0AGTR1, AGT
17hyperglycemia30.0NOS2, NOS3, AGT, AGTR1
18myocardial infarction29.9ECE1, AGTR1, AGT, NOS3, ADD1, PTGIS
19preeclampsia/eclampsia 129.9ECE1, NOS2, AGT, AGTR1, NOS3
20adenoma29.9PTGIS, CYP3A5, GNB3, ECE1
21impotence29.7NOS3, NOS2
22focal segmental glomerulosclerosis29.7NOS2, AGTR1
23chronic kidney failure29.7AGTR1, AGT, NOS3, GNB3
24atherosclerosis29.6AGT, AGTR1, NOS2, NOS3, ADD1, PTGIS
25diabetes mellitus, noninsulin-dependent29.5AGTR1, AGT, NOS3, GNB3
26intracranial hypertension11.1
27renovascular hypertension11.1
28malignant hypertension11.0
29ocular hypertension11.0
30renal hypertension11.0
31chronic thromboembolic pulmonary hypertension11.0
33hypertensive heart disease11.0
35hypertensive encephalopathy10.9
36open-angle glaucoma10.8
37hypertensive retinopathy10.8
39neurogenic hypertension10.7
43pediatric hypertension10.7
45connective tissue disease10.6
49artery disease10.6

Graphical network of the top 20 diseases related to Hypertension, Essential:

Diseases related to hypertension, essential

Symptoms for Hypertension, Essential

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Symptoms by clinical synopsis from OMIM:


Clinical features from OMIM:


HPO human phenotypes related to Hypertension, Essential:

id Description Frequency HPO Source Accession
1 multifactorial inheritance HP:0001426
2 elevated systolic blood pressure HP:0004421
3 elevated mean arterial pressure HP:0004972
4 elevated diastolic blood pressure HP:0005117

Drugs & Therapeutics for Hypertension, Essential

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Drug clinical trials:

Search ClinicalTrials for Hypertension, Essential

Search NIH Clinical Center for Hypertension, Essential

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Hypertension, Essential

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Genetic tests related to Hypertension, Essential:

id Genetic test Affiliating Genes
1 Essential Hypertension22

Anatomical Context for Hypertension, Essential

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MalaCards organs/tissues related to Hypertension, Essential:

Heart, Kidney, Lung

Animal Models for Hypertension, Essential or affiliated genes

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MGI Mouse Phenotypes related to Hypertension, Essential:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1AGTR1, AGT, NOS3, NOS2, PTGIS

Publications for Hypertension, Essential

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Variations for Hypertension, Essential

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Clinvar genetic disease variations for Hypertension, Essential:

id Gene Variation Type Significance SNP ID Assembly Location
1PTGISPTGIS, IVS9, T-C, +2single nucleotide variantPathogenic

Expression for genes affiliated with Hypertension, Essential

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LifeMap Discovery
Genes differentially expressed in tissues of Hypertension, Essential patients vs. healthy controls: 30 (show all 9)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1C12orf29chromosome 12 open reading frame 29Blood+3.240.000
2ATF1activating transcription factor 1Blood+3.230.000
3PIKFYVEphosphoinositide kinase, FYVE finger containingBlood+3.180.000
4EID1EP300 interacting inhibitor of differentiation 1Blood+3.080.000
5STAM2signal transducing adaptor molecule (SH3 domain and ITAM motif) 2Blood+3.070.000
7UFL1UFM1-specific ligase 1Blood+3.020.000
8SUB1SUB1 homolog (S. cerevisiae)Blood+3.000.000
9ANKRD12ankyrin repeat domain 12Blood+3.000.000

Search GEO for disease gene expression data for Hypertension, Essential.

Pathways for genes affiliated with Hypertension, Essential

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Pathways related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
Show member pathways
Show member pathways
39.7NOS2, NOS3
Show member pathways
9.7NOS2, NOS3
Show member pathways
9.7NOS2, NOS3
69.7NOS3, NOS2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis36
9.7NOS3, NOS2
89.7NOS3, GNB3, ECE1
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.5NOS2, NOS3, AGTR1
109.5AGTR1, NOS3, NOS2
Show member pathways
9.5GNB3, NOS2, NOS3
Show member pathways

Compounds for genes affiliated with Hypertension, Essential

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Compounds related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1perindopril44 50 1112.3AGT, NOS3, AGTR1
2candesartan44 50 28 1113.2AGTR1, NOS3, AGT
3diuretics5010.2ADD1, NOS3
4atenolol44 50 28 24 1114.2GNB3, AGT, AGTR1
5thiazide4410.2AGTR1, ADD1, GNB3
6diltiazem44 28 50 1113.2AGTR1, CYP3A5, AGT
7cv 119744410.1AGTR1, AGT
8magnesium lithospermate b4410.1NOS3, NOS2
9n-(3-(aminomethyl)benzyl)acetamidine44 1111.1NOS3, NOS2
10n5-(1-iminoethyl)-l-ornithine4410.1NOS2, NOS3
11aliskiren44 1111.1AGTR1, AGT
12l-thiocitrulline44 1111.1NOS2, NOS3
13nitrit4410.0NOS2, NOS3
14furosemide44 60 28 50 24 1115.0AGTR1, ADD1, GNB3
15s-ethylisothiourea44 1111.0NOS3, NOS2
16hydrochlorothiazide44 28 50 24 1114.0AGTR1, AGT, ADD1, GNB3
17amlodipine44 50 24 1113.0CYP3A5, NOS3, AGTR1, AGT
18captopril44 60 50 28 1114.0AGT, AGTR1, ECE1
19clonidine44 50 28 1113.0CYP3A5, GNB3, NOS3, AGTR1
20aminoguanidine44 28 1111.9AGTR1, NOS3, NOS2
21simvastatin44 50 60 28 24 1114.9AGTR1, CYP3A5, NOS3, AGT
22n(g)-nitro-l-arginine methyl ester449.9NOS2, NOS3, AGT
23onoo449.9NOS3, NOS2, PTGIS
24ng-nitro-l-arginine449.9NOS2, NOS3, AGT
253-bromo-7-nitroindazole60 1110.9NOS3, NOS2
26apocynin44 6010.9AGT, NOS3, NOS2
277-nitroindazole44 1110.9NOS2, NOS3
28n(g)-hydroxy-l-arginine449.8NOS2, NOS3
29rosuvastatin44 50 28 1112.8NOS3, NOS2, CYP3A5
30cerivastatin50 44 28 1112.8NOS3, CYP3A5, NOS2
31nitrate449.8PTGIS, NOS2, NOS3
32ang ii449.8NOS3, AGT, NOS2, AGTR1
33l-nmma449.8NOS2, AGTR1, AGT, NOS3
34phenylephrine44 28 24 1112.7NOS2, NOS3, AGT, AGTR1
35guanylate449.7AGTR1, AGT, NOS3, NOS2
36fluvastatin44 50 28 1112.7NOS3, NOS2, CYP3A5, AGTR1
37cgmp44 2810.7AGT, NOS2, NOS3, AGTR1
38sildenafil28 44 50 24 1113.7GNB3, NOS2, CYP3A5, NOS3
39sodium44 2410.6GNB3, CYP3A5, AGTR1, ADD1, AGT
40imidazole449.5NOS3, AGTR1, NOS2
41heme28 24 1111.5PTGIS, NOS2, NOS3, CYP3A5
42nitroglycerin44 1110.5GNB3, AGTR1, NOS2, PTGIS, NOS3
43cholesterol44 28 24 1112.5PTGIS, ADD1, AGTR1, ECE1, GNB3, AGT
44actinomycin d449.4NOS2, AGT, NOS3, AGTR1, ECE1
45nadph44 2410.4NOS3, CYP3A5, NOS2, AGT, AGTR1
46superoxide44 2410.4PTGIS, NOS2, NOS3, AGT, AGTR1
47prostacyclin449.2AGTR1, AGT, NOS3, NOS2, PTGIS, ECE1
48diphenyleneiodonium449.2NOS2, NOS3, AGT
49nitric oxide44 24 1110.8AGT, GNB3, PTGIS, ADD1, NOS2, NOS3
50oxygen44 249.7AGT, NOS3, AGTR1, NOS2, PTGIS, CYP3A5

GO Terms for genes affiliated with Hypertension, Essential

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Biological processes related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:003386410.4AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:000203410.4AGT, AGTR1
3regulation of renal sodium excretionGO:003581310.4AGT, AGTR1
4renin-angiotensin regulation of aldosterone productionGO:000201810.4AGT, AGTR1
5positive regulation of cholesterol esterificationGO:001087310.3AGTR1, AGT
6low-density lipoprotein particle remodelingGO:003437410.3AGT, AGTR1
7regulation of systemic arterial blood pressure by endothelinGO:000310010.3ECE1, NOS3
8positive regulation of cellular protein metabolic processGO:003227010.2AGTR1, AGT
9positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGTR1, AGT
10regulation of vasoconstrictionGO:001922910.1AGTR1, AGT, ECE1
11positive regulation of angiogenesisGO:004576610.0NOS3, ADD1, PTGIS
12positive regulation of guanylate cyclase activityGO:003128410.0NOS2, NOS3
13arginine catabolic processGO:000652710.0NOS2, NOS3
14positive regulation of reactive oxygen species metabolic processGO:0200037910.0AGT, AGTR1
15nitric oxide biosynthetic processGO:00068099.9NOS3, NOS2
16nitric oxide mediated signal transductionGO:00072639.9AGT, NOS3, NOS2
17negative regulation of blood pressureGO:00457769.7NOS3, NOS2
18interaction with hostGO:00517019.7NOS3, NOS2
19regulation of blood pressureGO:00082179.7NOS3, ACSM3, GNB3
20regulation of cell proliferationGO:00421279.7NOS2, AGT, AGTR1
21positive regulation of vasodilationGO:00459099.4NOS2, NOS3

Molecular functions related to Hypertension, Essential according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:000449710.0PTGIS, CYP3A5
2nitric-oxide synthase activityGO:00045179.9NOS3, NOS2
3arginine bindingGO:00346189.8NOS2, NOS3
4tetrahydrobiopterin bindingGO:00346179.8NOS2, NOS3
5NADPH-hemoprotein reductase activityGO:00039589.7NOS3, NOS2
6FMN bindingGO:00101819.6NOS2, NOS3
7heme bindingGO:00200379.4NOS3, NOS2, PTGIS, CYP3A5
8iron ion bindingGO:00055069.4CYP3A5, PTGIS, NOS2, NOS3
9calmodulin bindingGO:00055169.2NOS3, NOS2, ADD1

Sources for Hypertension, Essential

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26ICD10 via Orphanet
34MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet