MCID: HYP034
MIFTS: 38

Hypertensive Encephalopathy malady

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Hypertensive Encephalopathy

Aliases & Descriptions for Hypertensive Encephalopathy:

Name: Hypertensive Encephalopathy 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9427
ICD10 33 I67.4
ICD9CM 35 437.2
MeSH 42 D020343
NCIt 47 C3503
UMLS 69 C0151620

Summaries for Hypertensive Encephalopathy

MalaCards based summary : Hypertensive Encephalopathy is related to encephalopathy and cerebritis. An important gene associated with Hypertensive Encephalopathy is EPO (Erythropoietin), and among its related pathways/superpathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin secretion. The drugs Colchicine and Peginterferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and kidney, and related phenotype is cardiovascular system.

Wikipedia : 71 Hypertensive encephalopathy is a neurological dysfunction induced by hypertensive emergency. The term... more...

Related Diseases for Hypertensive Encephalopathy

Diseases related to Hypertensive Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 encephalopathy 10.7
2 cerebritis 10.1
3 hypotrichosis simplex 10.1 ACE REN
4 hyperinsulinemic hypoglycemia, familial, 3 10.1 ACE REN
5 carbohydrate metabolic disorder 10.1 ACE REN
6 hypothyroidism, congenital nongoitrous, 5 10.1 ACE REN
7 hypogonadism mitral valve prolapse mental retardation 10.1 ACE REN
8 listeriosis 10.1 ACE REN
9 iris disease 10.1 ACE REN
10 congenital nystagmus 10.1 ACE REN
11 prostate neuroendocrine neoplasm 10.1 ACE REN
12 cascade stomach 10.1 ACE REN
13 hyperuricemic nephropathy, familial juvenile 2 10.1 ACE REN
14 chylocele of tunica vaginalis 10.1 ACE REN
15 eastern equine encephalitis 10.1 ACE REN
16 myopia 10.1 ACE REN
17 flat umbilicus familial 10.0 ACE REN
18 lymphadenitis 10.0 ACE REN
19 microphthalmia, isolated, with coloboma 7 10.0 ACE REN
20 pulmonary valve insufficiency 10.0 ACE REN
21 schizotypal personality disorder 10.0 ACE REN
22 clear cell adenocarcinoma 10.0 ACE REN
23 aorta angiosarcoma 10.0 ACE REN
24 dilated cardiomyopathy 10.0 ACE EPO
25 deafness, autosomal recessive 79 10.0 ACE REN
26 familial nephrotic syndrome 10.0 ACE EPO
27 pyelonephritis 10.0 ACE REN
28 mixed germ cell-sex cord neoplasm 10.0 ACE REN
29 limb ischemia 10.0 ACE REN
30 malignant hypertension 10.0
31 nephrogenic adenofibroma 10.0 CYP19A1 EPO
32 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.0 ACE REN
33 spinocerebellar ataxia 25 9.9 CYP19A1 REN
34 diabetic encephalopathy 9.9 ACE REN
35 petrositis 9.9 ACE EPO REN
36 pythiosis 9.9 ACE EPO REN
37 calcinosis 9.9 ACE EPO REN
38 chronic myocardial ischemia 9.9 ACE EPO REN
39 critical limb ischemia 9.9 ACE EPO REN
40 gastrointestinal lymphoma 9.9 ACE REN
41 peroneal neuropathy 9.9 ACE REN
42 lung giant cell carcinoma 9.9 ACE EPO REN
43 headache 9.9
44 eclampsia 9.9
45 glomerulonephritis 9.8
46 pinguecula 9.8 CYP19A1 REN
47 cervix small cell carcinoma 9.8 ACE REN
48 hydrocephalus 9.7
49 status epilepticus 9.7
50 cerebral arteriosclerosis 9.7

Comorbidity relations with Hypertensive Encephalopathy via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Acute Kidney Failure
Anxiety Disorder Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Malignant Essential Hypertension Malignant Renovascular Hypertension
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypertensive Encephalopathy:



Diseases related to Hypertensive Encephalopathy

Symptoms & Phenotypes for Hypertensive Encephalopathy

MGI Mouse Phenotypes related to Hypertensive Encephalopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 ACE CYP19A1 EPO REN VLDLR

Drugs & Therapeutics for Hypertensive Encephalopathy

Drugs for Hypertensive Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colchicine Approved Phase 4 64-86-8 6167 2833
2
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
3
Mannitol Approved, Investigational Phase 4,Phase 2,Phase 3 69-65-8 453 6251
4
Prazosin Approved Phase 4 19216-56-9 4893
5
Ramipril Approved Phase 4 87333-19-5 5362129
6
Losartan Approved Phase 4,Phase 3 114798-26-4 3961
7
Amlodipine Approved Phase 4 88150-42-9 2162
8
Pravastatin Approved Phase 4 81093-37-0 54687
9
Simvastatin Approved Phase 4 79902-63-9 54454
10
Fluvastatin Approved Phase 4 93957-54-1 1548972
11
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
12
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
13
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
14
Candesartan Approved Phase 4 139481-59-7 2541
15
Telmisartan Approved, Investigational Phase 4,Phase 2 144701-48-4 65999
16
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
17
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
18 interferons Phase 4
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 4,Phase 3
22 Interferon-alpha Phase 4
23 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Antimitotic Agents Phase 4
25 Antirheumatic Agents Phase 4,Phase 1
26 Antiviral Agents Phase 4
27
Angiotensin II Phase 4,Phase 3,Phase 2 68521-88-0, 11128-99-7 65143 172198
28 calcium channel blockers Phase 4,Phase 3,Phase 2
29
protease inhibitors Phase 4,Phase 3,Phase 2
30 Adrenergic Agents Phase 4,Phase 2,Phase 3
31 Adrenergic Antagonists Phase 4,Phase 2,Phase 3
32 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 2,Phase 3
33 Adrenergic alpha-Antagonists Phase 4,Phase 2,Phase 3
34 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3
35 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
36 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Phase 2
37 Angiotensin Receptor Antagonists Phase 4,Phase 3,Phase 2
38 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2
39 Angiotensinogen Phase 4,Phase 3,Phase 2
40 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
41 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
42 Calcium, Dietary Phase 4,Phase 3,Phase 2
43
Olmesartan medoxomil Phase 4 144689-63-4 130881
44 Atorvastatin Calcium Phase 4 134523-03-8
45 Rosuvastatin Calcium Phase 4 147098-20-2
46
Candesartan cilexetil Phase 4 145040-37-5 2540
47 diuretics Phase 4,Phase 2,Phase 3
48 Natriuretic Agents Phase 4,Phase 2,Phase 3
49 Hormone Antagonists Phase 4,Phase 3
50 Hormones Phase 4,Phase 3

Interventional clinical trials:

(show all 50)
id Name Status NCT ID Phase
1 Study of Long-Term Peg Intron Vs. Colchicine in Non-Responders. Unknown status NCT00179413 Phase 4
2 Diurnal Variation in Hypertensive Stroke Patients Completed NCT01830517 Phase 4
3 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4
4 Studying the Effects of Antihypertensives on Individuals at Risk for Alzheimer's Completed NCT00980785 Phase 4
5 Recurrent Stroke Prevention Clinical Outcome Study Recruiting NCT01198496 Phase 4
6 Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives Recruiting NCT01563731 Phase 4
7 Prazosin for Post-Concussive Headaches Recruiting NCT02965027 Phase 4
8 The Efficacy of Nitric Oxide in Stroke (ENOS) Trial Unknown status NCT00989716 Phase 3
9 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3
10 Effectiveness of Self-monitoring and Treatment of Blood Pressure Following Stroke or Transient Ischaemic Attack Completed NCT02947490 Phase 3
11 Cilnidipine Effect on High Blood Pressure and Cerebral Perfusion in Ischemic Stroke Patients With Hypertension Completed NCT00325637 Phase 3
12 Home Blood Pressure Monitoring Trial Completed NCT00514800 Phase 3
13 Start or STop Anticoagulants Randomised Trial (SoSTART) Not yet recruiting NCT03153150 Phase 3
14 Sodium-Lactate and Traumatic Brain Injury Terminated NCT00319345 Phase 2, Phase 3
15 Antihypertensive Treatment of Acute Cerebral Hemorrhage-II Terminated NCT01176565 Phase 3
16 Study Comparing Effect On Carotid Atherosclerosis Following Conversion From Tacrolimus To Sirolimus Post-Transplant In Kidney Transplant Patients Terminated NCT00311311 Phase 3
17 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3
18 Field Administration of Stroke Therapy-Blood Pressure Lowering Unknown status NCT01811693 Phase 2
19 Effects of Saline on Circulation in Children Completed NCT01668277 Phase 2
20 Phase II Study of Lactulose and Circadian Rhythms in Patients With Cirrhosis Completed NCT00004796 Phase 2
21 Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial Completed NCT00963976 Phase 2
22 Preventing Recurrence of Thromboembolic Events Through Coordinated Treatment in the District of Columbia Completed NCT00703274 Phase 2
23 Telmisartan vs. Perindopril in Hypertensive Mild-Moderate Alzheimer's Disease Patients Recruiting NCT02085265 Phase 2
24 Dose-effect Relationship of Rt-PA on ICH Evacuation Active, not recruiting NCT02472574 Phase 2
25 Intravenous Immunoglobulin for Acute Intracranial Hemorrhage Not yet recruiting NCT02782897 Phase 2
26 Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic Recruiting NCT02726711 Phase 1
27 Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage Not yet recruiting NCT01865630 Phase 1
28 Modified Stereotactic Aspiration and Thrombolysis of Intracerebral Hemorrhage:a Multi-center Controlled Study Unknown status NCT00940745
29 Stereotactic Aspiration and Thrombolysis of Intracerebral Hemorrhage: a Prospective Controlled Study Unknown status NCT00752024
30 Evaluation of Effectiveness of Nutritional Counseling in Patients After Stroke Unknown status NCT01517542
31 MRI for the Early Evaluation of Acute Intracerebral Hemorrhage Unknown status NCT01689402
32 A Blood Pressure Regulation and Stroke Risk Evaluation Study in Hypertensive Patients Treated With Eprosartan Completed NCT01562613
33 Monitoring Hypertensive Patients's Cerebral Oxygen Saturation Completed NCT02147275
34 Analyzing How Genetics May Affect Response to High Blood Pressure Medications Completed NCT00563901
35 Antihypertensive Drug/Gene Interactions and CV Events Completed NCT00005332
36 Atrial Fibrillation Incidence, Risk Factors and Genetics Completed NCT00021905
37 Prazosin Treatment for Disruptive Agitation in Alzheimer's Disease Completed NCT01126099
38 Role of Obstructive Sleep Apnea in Stroke Appearance Completed NCT00613522
39 Prognostic Observation of Posterior Reversible Encephalopathy Syndrome Recruiting NCT02665598
40 Minimally-invasive Surgery Versus Craniotomy in Patients With Supratentorial Hypertensive Intracerebral Hemorrhage Recruiting NCT02811614
41 Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study Recruiting NCT02912546
42 PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome Recruiting NCT03100084
43 Connected Health Blood Pressure Monitoring In Stroke and TIA Patients Recruiting NCT02450760
44 Impact of Controlling Vascular Risk Factors on the Progression of Alzheimer's Disease Recruiting NCT01423396
45 POSITIVE Stroke Clinical Trial Recruiting NCT01852201
46 Culturally Tailoring a Stroke Intervention in Community Senior Centers Active, not recruiting NCT02181062
47 Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES): Terminated NCT02027272
48 Aneurysmal Subarachnoid Hemorrhage and Superior Mesenteric Artery Flow Study Terminated NCT02684500
49 Midodrine for Ischemic Stroke With Penumbra Withdrawn NCT02383121
50 Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage Withdrawn NCT01232400

Search NIH Clinical Center for Hypertensive Encephalopathy

Cochrane evidence based reviews: hypertensive encephalopathy

Genetic Tests for Hypertensive Encephalopathy

Anatomical Context for Hypertensive Encephalopathy

MalaCards organs/tissues related to Hypertensive Encephalopathy:

39
Brain, Retina, Kidney, Spinal Cord, Neutrophil, Cerebellum, Pons

Publications for Hypertensive Encephalopathy

Articles related to Hypertensive Encephalopathy:

(show top 50) (show all 253)
id Title Authors Year
1
A Case of Hypertensive Encephalopathy with Enlarged Optic Nerve Sheath Measured by Transorbital Sonography. ( 27838176 )
2017
2
Hypertensive encephalopathy: what's in a name? ( 27067368 )
2016
3
Risk of Stroke After the International Classification of Diseases-Ninth Revision Discharge Code Diagnosis of Hypertensive Encephalopathy. ( 26742804 )
2016
4
Allgrove Syndrome: Adrenal Insufficiency with Hypertensive Encephalopathy. ( 27671188 )
2016
5
Acute hypertensive encephalopathy presenting with a partial third nerve palsy: image findings. ( 27932433 )
2016
6
Does this patient have hypertensive encephalopathy? ( 26896240 )
2016
7
Hypertensive Encephalopathy and Renal Failure in a Young Man. ( 26597825 )
2016
8
Hypertensive encephalopathy associated with obstructive sleep apnoea syndrome. ( 25638253 )
2015
9
Venlafaxine as single therapy associated with hypertensive encephalopathy. ( 25763307 )
2015
10
Magnetic resonance imaging appearance of hypertensive encephalopathy in a dog. ( 25949801 )
2015
11
Renal artery stenosis: An unusual etiology of hypertensive encephalopathy in a child with fanconi anemia. ( 26178556 )
2015
12
Malignant systemic hypertension, encephalopathy and bradycardia following splenectomy for hereditary spherocytosis. ( 26009599 )
2015
13
Increasing trend in admissions for malignant hypertension and hypertensive encephalopathy in the United States. ( 25801877 )
2015
14
Asymmetric Posterior Reversible Encephalopathy Syndrome due to Hypertensive Encephalopathy. ( 25876591 )
2015
15
Hypertensive encephalopathy and cerebral infarction. ( 25932363 )
2014
16
Hypertensive encephalopathy as a late complication of autonomic dysreflexia in a 12-year-old boy with a previous spinal cord injury. ( 24535713 )
2014
17
Hypertension and hypertensive encephalopathy. ( 24365295 )
2014
18
Serial MR spectroscopy in hypertensive encephalopathy. ( 25394908 )
2014
19
Estrogens are neuroprotective factors for hypertensive encephalopathy. ( 24736028 )
2014
20
Risk of subsequent dementia in patients with hypertensive encephalopathy: a nationwide population-based study in Taiwan. ( 24513673 )
2014
21
A case of Liddle's syndrome; unusual presentation with hypertensive encephalopathy. ( 24969204 )
2014
22
Hypertensive encephalopathy associated with anabolic-androgenic steroids used for bodybuilding. ( 25319132 )
2014
23
Characteristic electrocardiographic repolarisation changes in a 9 year-old boy with hypertensive encephalopathy. ( 23788105 )
2013
24
Concealed primary aortic sarcoma induced hypertensive encephalopathy resulting from a thoracic aortic occlusion: a case report. ( 23597173 )
2013
25
Hypertensive encephalopathy following snake bite in a child: A diagnostic dilemma. ( 23983418 )
2013
26
Risks of subsequent epilepsy among patients with hypertensive encephalopathy: a nationwide population-based study. ( 24090775 )
2013
27
Hypertensive encephalopathy as the initial manifestation of Guillain-Barre syndrome in a 7-year-old girl. ( 23887224 )
2013
28
Isolated brainstem involvement in a patient with hypertensive encephalopathy. ( 23533856 )
2013
29
Severe hypertensive encephalopathy following percutaneous balloon aortic valvuloplasty for aortic stenosis. ( 24377710 )
2013
30
Hypertensive encephalopathy as the initial manifestation of Guillain-BarrAc syndrome in a 7-year-old girl. ( 23545616 )
2013
31
Hypertensive encephalopathy with reversible brainstem edema. ( 24175031 )
2013
32
Clinicopathologic and MRI characteristics of presumptive hypertensive encephalopathy in two cats and two dogs. ( 24051253 )
2013
33
Neuroprotection and sex steroid hormones: evidence of estradiol-mediated protection in hypertensive encephalopathy. ( 22827218 )
2012
34
Reversible obstructive hydrocephalus from hypertensive encephalopathy. ( 22234407 )
2012
35
Hypertensive encephalopathy. ( 24665265 )
2012
36
Pheochromocytoma: a rare cause of childhood hypertensive encephalopathy. ( 22868025 )
2012
37
Malignant hypertension with reversible brainstem hypertensive encephalopathy and thrombotic microangiopathy. ( 22418002 )
2012
38
Hypertensive encephalopathy presenting as status epilepticus in a three year old. ( 21903352 )
2012
39
Cyclophosphamide-induced hypertensive encephalopathy in a young girl with lupus. ( 22458753 )
2012
40
Prolonged enhancement of the subarachnoid space on FLAIR imaging in hypertensive encephalopathy. ( 21510244 )
2011
41
Hypertensive encephalopathy: a rare presentation of Williams-Beuren Syndrome. ( 21798143 )
2011
42
Reversible brainstem edema due to hypertensive encephalopathy in an 8-year-old girl. ( 21527395 )
2011
43
Accelerated kidney transplant rejection and hypertensive encephalopathy in a pediatric patient associated with antibodies against angiotensin type 1 receptor and HLA class II. ( 22067217 )
2011
44
Impressive hypertensive encephalopathy. ( 21617160 )
2011
45
When should nitroglycerine be avoided in hypertensive encephalopathy? ( 21931071 )
2011
46
Value of retinal examination in hypertensive encephalopathy. ( 19865107 )
2010
47
Isolated brainstem involvement in a patient with hypertensive encephalopathy. ( 20714952 )
2010
48
A case of hypertensive encephalopathy with extensive spinal lesions on MRI. ( 19733990 )
2010
49
Reversible cognitive impairment in hypertensive encephalopathy. ( 20847514 )
2010
50
Hypertensive encephalopathy in patients with chronic renal failure caused by stopping antihypertensive agents: a report of two cases. ( 20013140 )
2010

Variations for Hypertensive Encephalopathy

Expression for Hypertensive Encephalopathy

Search GEO for disease gene expression data for Hypertensive Encephalopathy.

Pathways for Hypertensive Encephalopathy

Pathways related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 ACE REN
2 10.44 ACE REN

GO Terms for Hypertensive Encephalopathy

Cellular components related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ACE EPO REN VLDLR

Biological processes related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.32 ACE REN
2 regulation of blood pressure GO:0008217 9.26 ACE REN
3 positive regulation of protein kinase activity GO:0045860 9.16 EPO VLDLR
4 beta-amyloid metabolic process GO:0050435 8.96 ACE REN
5 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Hypertensive Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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