MCID: HYP034
MIFTS: 34

Hypertensive Encephalopathy

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Hypertensive Encephalopathy

MalaCards integrated aliases for Hypertensive Encephalopathy:

Name: Hypertensive Encephalopathy 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9427
ICD10 32 I67.4
ICD9CM 34 437.2
MeSH 41 D020343
NCIt 46 C3503
UMLS 69 C0151620

Summaries for Hypertensive Encephalopathy

MalaCards based summary : Hypertensive Encephalopathy is related to renal hypertension and encephalopathy. An important gene associated with Hypertensive Encephalopathy is EPO (Erythropoietin). The drugs Peripheral Nervous System Agents and Autonomic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and kidney.

Wikipedia : 72 Hypertensive encephalopathy (HE) is general brain dysfunction due to significantly high blood pressure.... more...

Related Diseases for Hypertensive Encephalopathy

Diseases related to Hypertensive Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 renal hypertension 29.4 ACE EPO
2 encephalopathy 10.8
3 cerebritis 10.2
4 hydrops, lactic acidosis, and sideroblastic anemia 10.1
5 malignant hypertension 10.1
6 renal artery disease 10.0 ACE EPO
7 pure autonomic failure 10.0 ACE EPO
8 headache 10.0
9 end stage renal failure 10.0 ACE EPO
10 eclampsia 9.9
11 diabetic neuropathy 9.9 ACE EPO
12 urinary system disease 9.9 ACE EPO
13 glomerulonephritis 9.9
14 immune system disease 9.9 ACE EPO
15 hydrocephalus 9.8
16 congestive heart failure 9.8 ACE EPO
17 myoma 9.8 CYP19A1 EPO
18 chronic kidney failure 9.7 ACE EPO
19 pheochromocytoma 9.7
20 stroke, ischemic 9.7
21 polyarteritis nodosa, childhood-onset 9.7
22 arteriovenous fistula 9.7
23 nephrotic syndrome 9.7
24 dementia 9.7
25 acute poststreptococcal glomerulonephritis 9.7
26 status epilepticus 9.7
27 arteriosclerosis 9.7
28 polyarteritis nodosa 9.7
29 cerebral arteriosclerosis 9.7
30 ischemia 9.6 ACE EPO
31 blood group, i system 9.6
32 fibrosis of extraocular muscles, congenital, 1 9.6
33 migraine with or without aura 1 9.6
34 schizophrenia 9.6
35 williams-beuren syndrome 9.6
36 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.6
37 fanconi anemia, complementation group a 9.6
38 achalasia-addisonianism-alacrima syndrome 9.6
39 popliteal pterygium syndrome, lethal type 9.6
40 graves disease 1 9.6
41 aging 9.6
42 wilms tumor 5 9.6
43 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.6
44 wilms tumor 6 9.6
45 cerebral hemorrhage 9.6
46 hepatitis 9.6
47 hepatitis b 9.6
48 sinusitis 9.6
49 spinal cord injury 9.6
50 phaeochromocytoma 9.6

Comorbidity relations with Hypertensive Encephalopathy via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Acute Kidney Failure
Anxiety Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Malignant Essential Hypertension Malignant Renovascular Hypertension
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypertensive Encephalopathy:



Diseases related to Hypertensive Encephalopathy

Symptoms & Phenotypes for Hypertensive Encephalopathy

Drugs & Therapeutics for Hypertensive Encephalopathy

Drugs for Hypertensive Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Peripheral Nervous System Agents Phase 2, Phase 3
2 Autonomic Agents Phase 2, Phase 3
3
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
4 Dexamethasone acetate 1177-87-3
5 glucocorticoids
6
protease inhibitors
7 Gastrointestinal Agents
8 HIV Protease Inhibitors
9 Hormone Antagonists
10 Hormones
11 Hormones, Hormone Substitutes, and Hormone Antagonists
12 Antiemetics
13 Anti-Inflammatory Agents
14 Antineoplastic Agents, Hormonal
15 BB 1101

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
2 Effects of Saline on Circulation in Children Completed NCT01668277 Phase 2 7.2% NaCl;0.9% NaCl
3 Prognostic Observation of Posterior Reversible Encephalopathy Syndrome Recruiting NCT02665598
4 Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES): Terminated NCT02027272 Dexamethasone

Search NIH Clinical Center for Hypertensive Encephalopathy

Cochrane evidence based reviews: hypertensive encephalopathy

Genetic Tests for Hypertensive Encephalopathy

Anatomical Context for Hypertensive Encephalopathy

MalaCards organs/tissues related to Hypertensive Encephalopathy:

38
Brain, Eye, Kidney, Spinal Cord, Neutrophil, Pons, Cerebellum

Publications for Hypertensive Encephalopathy

Articles related to Hypertensive Encephalopathy:

(show top 50) (show all 259)
# Title Authors Year
1
'Khatatonia' - cathinone-induced hypertensive encephalopathy. ( 29256414 )
2017
2
Venous hypertensive encephalopathy secondary to venous sinus thrombosis and dural arteriovenous fistula. ( 28512209 )
2017
3
Clinical characteristics of hypertensive encephalopathy in pediatric patients. ( 29042869 )
2017
4
Hypertensive encephalopathy mimicking cerebral vasculitis with pontine oedema, cerebellar white matter lesions and multiple cerebral infarctions. ( 28724595 )
2017
5
Hypertensive Encephalopathy: A Case of a Male Who Bit Off His Fingers. ( 28979829 )
2017
6
A Case of Hypertensive Encephalopathy with Enlarged Optic Nerve Sheath Measured by Transorbital Sonography. ( 27838176 )
2017
7
Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy. ( 29284571 )
2017
8
Risk of Stroke After the International Classification of Diseases-Ninth Revision Discharge Code Diagnosis of Hypertensive Encephalopathy. ( 26742804 )
2016
9
Allgrove Syndrome: Adrenal Insufficiency with Hypertensive Encephalopathy. ( 27671188 )
2016
10
Hypertensive Encephalopathy and Renal Failure in a Young Man. ( 26597825 )
2016
11
Hypertensive encephalopathy: what's in a name? ( 27067368 )
2016
12
Acute hypertensive encephalopathy presenting with a partial third nerve palsy: image findings. ( 27932433 )
2016
13
Does this patient have hypertensive encephalopathy? ( 26896240 )
2016
14
Magnetic resonance imaging appearance of hypertensive encephalopathy in a dog. ( 25949801 )
2015
15
Renal artery stenosis: An unusual etiology of hypertensive encephalopathy in a child with fanconi anemia. ( 26178556 )
2015
16
Asymmetric Posterior Reversible Encephalopathy Syndrome due to Hypertensive Encephalopathy. ( 25876591 )
2015
17
Venlafaxine as single therapy associated with hypertensive encephalopathy. ( 25763307 )
2015
18
Increasing trend in admissions for malignant hypertension and hypertensive encephalopathy in the United States. ( 25801877 )
2015
19
Malignant systemic hypertension, encephalopathy and bradycardia following splenectomy for hereditary spherocytosis. ( 26009599 )
2015
20
Hypertensive encephalopathy associated with obstructive sleep apnoea syndrome. ( 25638253 )
2015
21
A case of Liddle's syndrome; unusual presentation with hypertensive encephalopathy. ( 24969204 )
2014
22
Estrogens are neuroprotective factors for hypertensive encephalopathy. ( 24736028 )
2014
23
Risk of subsequent dementia in patients with hypertensive encephalopathy: a nationwide population-based study in Taiwan. ( 24513673 )
2014
24
Hypertensive encephalopathy as a late complication of autonomic dysreflexia in a 12-year-old boy with a previous spinal cord injury. ( 24535713 )
2014
25
Hypertensive encephalopathy associated with anabolic-androgenic steroids used for bodybuilding. ( 25319132 )
2014
26
Serial MR spectroscopy in hypertensive encephalopathy. ( 25394908 )
2014
27
Hypertensive encephalopathy and cerebral infarction. ( 25932363 )
2014
28
Hypertension and hypertensive encephalopathy. ( 24365295 )
2014
29
Concealed primary aortic sarcoma induced hypertensive encephalopathy resulting from a thoracic aortic occlusion: a case report. ( 23597173 )
2013
30
Risks of subsequent epilepsy among patients with hypertensive encephalopathy: a nationwide population-based study. ( 24090775 )
2013
31
Characteristic electrocardiographic repolarisation changes in a 9 year-old boy with hypertensive encephalopathy. ( 23788105 )
2013
32
Hypertensive encephalopathy as the initial manifestation of Guillain-Barre syndrome in a 7-year-old girl. ( 23887224 )
2013
33
Isolated brainstem involvement in a patient with hypertensive encephalopathy. ( 23533856 )
2013
34
Hypertensive encephalopathy with reversible brainstem edema. ( 24175031 )
2013
35
Severe hypertensive encephalopathy following percutaneous balloon aortic valvuloplasty for aortic stenosis. ( 24377710 )
2013
36
Clinicopathologic and MRI characteristics of presumptive hypertensive encephalopathy in two cats and two dogs. ( 24051253 )
2013
37
Hypertensive encephalopathy following snake bite in a child: A diagnostic dilemma. ( 23983418 )
2013
38
Hypertensive encephalopathy as the initial manifestation of Guillain-BarrAc syndrome in a 7-year-old girl. ( 23545616 )
2013
39
Hypertensive encephalopathy presenting as status epilepticus in a three year old. ( 21903352 )
2012
40
Reversible obstructive hydrocephalus from hypertensive encephalopathy. ( 22234407 )
2012
41
Pheochromocytoma: a rare cause of childhood hypertensive encephalopathy. ( 22868025 )
2012
42
Malignant hypertension with reversible brainstem hypertensive encephalopathy and thrombotic microangiopathy. ( 22418002 )
2012
43
Neuroprotection and sex steroid hormones: evidence of estradiol-mediated protection in hypertensive encephalopathy. ( 22827218 )
2012
44
Hypertensive encephalopathy. ( 24665265 )
2012
45
Cyclophosphamide-induced hypertensive encephalopathy in a young girl with lupus. ( 22458753 )
2012
46
Impressive hypertensive encephalopathy. ( 21617160 )
2011
47
Prolonged enhancement of the subarachnoid space on FLAIR imaging in hypertensive encephalopathy. ( 21510244 )
2011
48
Accelerated kidney transplant rejection and hypertensive encephalopathy in a pediatric patient associated with antibodies against angiotensin type 1 receptor and HLA class II. ( 22067217 )
2011
49
Hypertensive encephalopathy: a rare presentation of Williams-Beuren Syndrome. ( 21798143 )
2011
50
Reversible brainstem edema due to hypertensive encephalopathy in an 8-year-old girl. ( 21527395 )
2011

Variations for Hypertensive Encephalopathy

Expression for Hypertensive Encephalopathy

Search GEO for disease gene expression data for Hypertensive Encephalopathy.

Pathways for Hypertensive Encephalopathy

GO Terms for Hypertensive Encephalopathy

Cellular components related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 ACE DPYSL3 EPO VLDLR
2 cell body GO:0044297 8.62 DPYSL3 EPO

Biological processes related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron projection development GO:0010976 9.16 DPYSL3 EPO
2 positive regulation of protein kinase activity GO:0045860 8.96 EPO VLDLR
3 response to axon injury GO:0048678 8.62 DPYSL3 EPO

Sources for Hypertensive Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....