MCID: HYP006
MIFTS: 50

Hypertensive Heart Disease malady

Cardiovascular diseases category

Summaries for Hypertensive Heart Disease

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Hypertensive heart disease includes a number of complications of systemic arterial hypertension or high... more...

MalaCards: Hypertensive Heart Disease is related to hypertension and coronary artery disease. An important gene associated with Hypertensive Heart Disease is NPR1 (natriuretic peptide receptor 1), and among its related pathways are PPAR signaling pathway and Adipocytokine signaling pathway. The compounds urodilatin and gw9662 have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and endothelial, and related mouse phenotypes are immune system and muscle.

Disease Ontology:9 A heart disease that is caused by high blood presure.

Aliases & Classifications for Hypertensive Heart Disease

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Related Diseases for Hypertensive Heart Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8PPARA, AGTR1, NPR1, NPPB
2coronary artery disease30.4NPPB, AGTR1
3vascular disease30.2AGTR1, PPARA
4essential hypertension30.2NPPB, AGTR1, NPR1
5cor pulmonale30.0NPPB, AGTR1
6myocardial infarction30.0NPPB, AGTR1, NPR1
7hypertrophic cardiomyopathy10.6
8ischemia10.4
9diastolic heart failure10.2
10artery disease10.2
11amyloidosis10.1
12dilated cardiomyopathy10.1
13left ventricular outflow tract obstruction10.1
14endotheliitis10.1
15familial hyperlipidemia10.0AGTR1, PPARA
16idiopathic edema10.0NPPB, PPARA
17hypercholesterolemia10.0PPARA, AGTR1
18osteoporosis10.0CD36
19hyperinsulinism10.0PPARA, AGTR1
20acute myocardial infarction10.0AGTR1, NPPB
21renal fibrosis10.0CD36, AGTR1
22arteriolosclerosis10.0
23rheumatic heart disease10.0
24dextrocardia10.0
25erythromelalgia10.0
26alcoholic cardiomyopathy10.0
27gastric ulcer10.0
28nephrosclerosis10.0
29situs inversus10.0
30polycystic kidney disease10.0
31cerebritis10.0
32fabry disease10.0
33angioedema10.0
34dermatitis10.0
35kidney disease10.0
36myocarditis10.0
37congenital varicella syndrome10.0
38dextrocardia with situs inversus10.0
39renal dysplasia10.0
40glomerulosclerosis10.0CD36, AGTR1
41pulmonary fibrosis10.0CD36, AGTR1
42noonan syndrome10.0AGTR1, NPPB
43congestive heart failure10.0NPR1, AGTR1, NPPB
44cerebrovascular disease10.0NPR1, NPPB, AGTR1
45congenital heart disease10.0PPARA, NPPB, AGTR1
46primary hyperoxaluria10.0PPARA, NPPB, AGTR1
47adenocarcinoma10.0AGTR1, NPR1, PPARA
48diabetic nephropathy10.0PPARA, CD36, AGTR1
49atherosclerosis9.9PPARA, CD36, AGTR1
50diabetes mellitus9.9PPARA, CD36, NPPB, AGTR1

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to hypertensive heart disease

Symptoms for Hypertensive Heart Disease

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Drugs & Therapeutics for Hypertensive Heart Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hypertensive Heart Disease

Drug clinical trials:

Search ClinicalTrials for Hypertensive Heart Disease

Search NIH Clinical Center for Hypertensive Heart Disease

Search CenterWatch for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

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Anatomical Context for Hypertensive Heart Disease

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34MalaCards
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MalaCards organs/tissues related to Hypertensive Heart Disease:

34
Heart, Monocytes, Endothelial, Tongue, Bone, Kidney, Testes, Bone marrow

Animal Models for Hypertensive Heart Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Hypertensive Heart Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2AGTR1, CD36, NPR1, PPARA
2MP:00053697.8PPARA, NPPB, NPR1, CD36
3MP:00053857.4AGTR1, CD36, NPR1, NPPB, PPARA

Publications for Hypertensive Heart Disease

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Sources:
53PubMed
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Articles related to Hypertensive Heart Disease:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. (24140724)
2013
2
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease. (23657971)
2013
3
Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities. (22886534)
2013
4
MRI differentiation of cardiomyopathy showing left ventricular hypertrophy and heart failure: differentiation between cardiac amyloidosis, hypertrophic cardiomyopathy, and hypertensive heart disease. (23996116)
2013
5
Elevated circulating fibrocyte levels in patients with hypertensive heart disease. (22796709)
2012
6
Hypertensive heart disease: bone marrow as a significant player in pathologic remodelling? (22895017)
2012
7
Should African-Americans with elevated blood pressure be routinely screened for hypertensive heart disease? (23190057)
2012
8
Cardiotrophin-1 in hypertensive heart disease. (22418690)
2012
9
Dominance of hypertensive heart disease in a tertiary hospital in southern Nigeria: an echocardiographic study. (22764633)
2012
10
Cardiac MRI assessed left ventricular hypertrophy in differentiating hypertensive heart disease from hypertrophic cardiomyopathy attributable to a sarcomeric gene mutation. (21274714)
2011
11
Preface: hypertension and hypertensive heart disease. (20937439)
2010
12
Is Smad3 the key to inflammation and fibrosis in hypertensive heart disease? (20231519)
2010
13
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. (19117407)
2009
14
Influence of the type and degree of left ventricular hypertrophy on the prevalence of ventricular arrhythmias in patients with hypertensive heart disease. (18936895)
2008
15
Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction. (17766279)
2007
16
31P-MR spectroscopic imaging in hypertensive heart disease. (16514468)
2006
17
Are myocardial fibrosis and diastolic dysfunction reversible in hypertensive heart disease? (16330908)
2005
18
New directions in the assessment and treatment of hypertensive heart disease. (16046900)
2005
19
Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists. (15372301)
2004
20
Monocyte chemoattractant protein-1: a key mediator of angiotensin II-induced target organ damage in hypertensive heart disease? (15076146)
2004
21
Clinical implications of apoptosis in hypertensive heart disease. (12679323)
2003
22
Candesartan cilexetil improves left ventricular function, left ventricular hypertrophy, and endothelial function in patients with hypertensive heart disease. (12419928)
2002
23
Cardioreparation in hypertensive heart disease. (11566936)
2001
24
Behavioral treatment of hypertensive heart disease in African Americans: rationale and design of a randomized controlled trial. (11763829)
2001
25
Cardiac involvement in autosomal-dominant polycystic kidney disease: a hypertensive heart disease. (11597036)
2001
26
Ischemia and fibrosis: the risk mechanisms of hypertensive heart disease. (10829097)
2000
27
Regression of myocardial fibrosis in hypertensive heart disease: diverse effects of various antihypertensive drugs. (10773237)
2000
28
Indicators and treatment of hypertensive heart disease. (10901763)
1999
29
Hypertensive heart disease. (10652906)
1999
30
Hypertensive heart disease, ventricular dysrhythmias, and sudden death. (9433533)
1997
31
Modulation of hypertensive heart disease by estrogen. (8733001)
1996
32
Diabetic and hypertensive heart disease. (8678395)
1996
33
Coronary microcirculation in hypertensive heart disease: functional significance and therapeutic implications. (8518540)
1993
34
Coronary haemodynamics in hypertensive heart disease. (1396859)
1992
35
Development of cardiac failure by coronary small vessel disease in hypertensive heart disease? (1838764)
1991
36
Coronary vascular changes in the progression and regression of hypertensive heart disease. (1720480)
1991
37
Predicting hypertensive heart disease via non-invasive methodology: relationship between ambulatory blood pressure and cardiac indices derived by echocardiography and radionuclide ventriculography. (2150531)
1990
38
Hypertensive heart disease: relationship of silent ischemia to coronary artery disease and left ventricular hypertrophy. (2145735)
1990
39
Comparative analysis of cardiac function, geometry, energetics and coronary reserve in hypertensive heart disease. (2962004)
1987
40
Usefulness of stress testing for the evaluation of hypertensive heart disease in young hypertensive subjects. (6488227)
1984
41
The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload. (6217955)
1983
42
Ischemic and hypertensive heart disease in the aged: prognostic and therapeutic factors. (7410762)
1980
43
Diastolic time intervals in ischemic and hypertensive heart disease: A comparison of isovolumic relaxation time and rapid filling time with systolic time intervals. (1149531)
1975
44
Clinical-physiological correlations in the development of hypertensive heart disease. (4255490)
1971
45
Hypertensive heart disease. (13933034)
1963
46
Prognosis of hypertensive heart disease. (13339176)
1956
47
Hypertensive heart disease, a confusing term; pathogenic considerations. (13274389)
1955
48
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
49
Recent trends in hypertensive heart disease. (15399041)
1950
50
Hypertensive heart disease; case report. (21004782)
1945

Variations for Hypertensive Heart Disease

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Expression for genes affiliated with Hypertensive Heart Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for genes affiliated with Hypertensive Heart Disease

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database
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Pathways related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
fatty acid beta-oxidation VI (peroxisome)39
9.1CD36, PPARA
29.1CD36, PPARA

Compounds for genes affiliated with Hypertensive Heart Disease

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1urodilatin469.8NPR1, NPPB
2gw966246 3010.8AGTR1, PPARA
38-bromo cgmp469.7NPPB, NPR1
4trandolapril46 1210.7AGTR1, NPPB
5fosinopril46 1210.7NPPB, AGTR1
6lisinopril46 52 25 1212.7NPPB, AGTR1
7ramipril46 1210.7AGTR1, NPPB
8aldosterone30 25 1211.7NPPB, AGTR1
9valsartan46 62 30 1212.7AGTR1, NPPB
10perindopril46 52 1211.6AGTR1, NPPB
11atenolol46 52 30 25 1213.6AGTR1, NPPB
12amiodarone46 52 30 1212.6NPPB, PPARA
13candesartan46 52 30 1212.6AGTR1, NPPB
14amlodipine46 52 25 1212.6NPPB, AGTR1
15enalapril46 52 1211.6AGTR1, NPPB
16spironolactone46 62 30 52 1213.5NPPB, AGTR1
17pd12331946 3010.5AGTR1, CD36
18carvedilol46 52 30 1212.5AGTR1, NPPB
198-isoprostane469.4NPPB, AGTR1
20digoxin46 62 52 25 1213.3AGTR1, NPPB
21nitroglycerin46 1210.3NPR1, NPPB, AGTR1
22sodium nitroprusside469.3AGTR1, NPPB, NPR1
23guanylate469.3NPPB, AGTR1, NPR1
24cgmp46 3010.3NPPB, AGTR1, NPR1
25telmisartan46 30 1211.3NPPB, PPARA, AGTR1
26p005469.2NPPB, AGTR1
27pravastatin46 52 30 25 1213.2NPPB, AGTR1, PPARA
28prostacyclin469.2PPARA, NPPB, AGTR1
29aspirin46 52 30 2512.2AGTR1, PPARA, NPPB
30norepinephrine46 25 1211.1PPARA, NPPB, AGTR1
31actinomycin d469.1NPPB, AGTR1, PPARA
32furosemide46 62 30 52 25 1214.0AGTR1, NPPB
33forskolin46 52 1211.0NPPB, AGTR1, NPR1
34ang ii468.9CD36, AGTR1, NPPB
35captopril46 62 52 30 1212.9AGTR1, NPPB, CD36
36pioglitazone30 46 52 1211.9CD36, NPPB, PPARA
37losartan46 52 30 1211.9AGTR1, NPPB, CD36
38sodium46 259.9NPPB, NPR1, AGTR1
39sb 20358046 629.8NPPB, CD36, AGTR1
40pge2468.6CD36, NPPB, PPARA
41rosiglitazone30 46 52 25 1212.4CD36, NPPB, PPARA, AGTR1
42tacrolimus46 52 1210.4CD36, NPPB, PPARA, AGTR1
43cysteine468.4CD36, NPR1, NPPB, AGTR1
44genistein46 30 62 3 25 1213.4PPARA, CD36, NPPB, AGTR1
45creatinine468.4NPPB, CD36, AGTR1, PPARA
46dexamethasone46 52 30 1211.4AGTR1, PPARA, NPPB, CD36
47vegf468.4AGTR1, PPARA, CD36, NPPB
48vitamin d468.0NPR1, NPPB, PPARA, AGTR1, CD36
49estrogen468.0PPARA, AGTR1, CD36, NPR1, NPPB
50serine468.0NPR1, NPPB, PPARA, AGTR1, CD36

GO Terms for genes affiliated with Hypertensive Heart Disease

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17Gene Ontology
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Cellular components related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7AGTR1, CD36, NPR1

Biological processes related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of vascular permeabilityGO:0431149.7NPR1, NPPB
2cGMP biosynthetic processGO:0061829.7NPR1, NPPB
3body fluid secretionGO:0075899.7NPR1, NPPB
4receptor guanylyl cyclase signaling pathwayGO:0071689.6NPR1, NPPB
5positive regulation of urine volumeGO:0358109.6NPR1, NPPB
6regulation of blood vessel sizeGO:0508809.6NPPB, NPR1
7positive regulation of renal sodium excretionGO:0358159.6NPPB, NPR1
8negative regulation of angiogenesisGO:0165259.5NPR1, NPPB
9regulation of blood pressureGO:0082179.4NPPB, NPR1
10positive regulation of macrophage derived foam cell differentiationGO:0107449.3AGTR1, CD36
11positive regulation of reactive oxygen species metabolic processGO:20003799.2AGTR1, CD36
12regulation of vasodilationGO:0423129.2AGTR1, NPR1, NPPB
13cellular lipid metabolic processGO:0442559.1CD36, PPARA
14negative regulation of cell growthGO:0303089.1NPR1, NPPB
15lipid metabolic processGO:0066299.0CD36, PPARA
16cell surface receptor signaling pathwayGO:0071668.8NPPB, NPR1, CD36

Molecular functions related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:0082899.1CD36, PPARA

Products for genes affiliated with Hypertensive Heart Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertensive Heart Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet