MCID: HYP006
MIFTS: 51

Hypertensive Heart Disease malady

Cardiovascular category

Summaries for Hypertensive Heart Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Hypertensive heart disease includes a number of complications of systemic arterial hypertension or high... more...

MalaCards: Hypertensive Heart Disease is related to coronary heart disease and hypertrophic cardiomyopathy. An important gene associated with Hypertensive Heart Disease is NPR1 (natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The compounds captopril and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include tongue, kidney and lung, and related mouse phenotypes are muscle and renal/urinary system.

Disease Ontology:8 A heart disease that is caused by high blood presure.

Aliases & Classifications for Hypertensive Heart Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Related Diseases for Hypertensive Heart Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1coronary heart disease31.0NPPB, PPARA, AGTR1, AGT, ACE
2hypertrophic cardiomyopathy31.0TPM1
3vascular disease30.5TIMP2, ANXA5
4coronary artery disease,30.4NPPB, NPPA, PPARA, AGTR1, AGT, ACE
5nephrosclerosis30.2NR3C2, AGTR1, ACE
6systolic heart failure10.3
7diastolic heart failure10.3
8amyloidosis10.2
9aortic disease10.2
10vein disease10.2
11left ventricular outflow tract obstruction10.2
12arteriolosclerosis10.0
13heart lymphoma10.0
14dextrocardia10.0
15gastric ulcer10.0
16alcoholic cardiomyopathy10.0
17erythromelalgia10.0
18miliary tuberculosis10.0
19situs inversus10.0
20polycystic kidney disease10.0
21fabry disease10.0
22acute pulmonary heart disease10.0
23angioedema10.0
24autosomal dominant disease10.0
25tongue disease10.0
26tuberculosis10.0
27polycystic kidney disease, autosomal dominant10.0
28congenital varicella syndrome10.0
29devic disease10.0
30cardiovascular disease risk factor10.0
31nutrition disease10.0
32rheumatic disease10.0
33renal dysplasia10.0
34mitral valve prolapse10.0AGTR1
35mitral valve disease10.0NPPA
36otosclerosis10.0CD36
37anuria10.0ACE
38glomerulonephritis10.0AGTR1
39gingivitis10.0MMP1
40oligohydramnios10.0ACE
41dermatitis10.0PPARA
42myocarditis10.0NPPB
43sick sinus syndrome10.0NPPA
44hepatitis b10.0PPARA
45ureteral obstruction10.0AGTR1
46hypoaldosteronism10.0CYP11B2
47carotid stenosis10.0MMP1
48kawasaki disease10.0NPPB
49familial hypertrophic cardiomyopathy10.0TPM1
50lung cancer10.0ANXA5

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to hypertensive heart disease

Clinical Features for Hypertensive Heart Disease

Drugs & Therapeutics for Hypertensive Heart Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypertensive Heart Disease

Drug clinical trials:

Search ClinicalTrials for Hypertensive Heart Disease

Search NIH Clinical Center for Hypertensive Heart Disease

Search CenterWatch for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

Anatomical Context for Hypertensive Heart Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hypertensive Heart Disease:

33
Tongue, Kidney, Lung, Bone marrow, Heart, Monocytes, T cells, B cells, Endothelial, Cardiac myocytes

Animal Models for Hypertensive Heart Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hypertensive Heart Disease

Sources:
51PubMed
See all sources

Articles related to Hypertensive Heart Disease:

(show top 50)    (show all 336)
idTitleAuthorsYear
1
Nebivolol: a multifaceted antioxidant and cardioprotectant in hypertensive heart disease. (23921314)
2013
2
Elevated circulating fibrocyte levels in patients with hypertensive heart disease. (22796709)
2012
3
Cardioprotective mechanisms of lifestyle modifications and pharmacotherapies on cardiac remodeling and dysfunction in hypertensive heart disease: an overview. (21928691)
2011
4
Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. (20823713)
2010
5
Hypertension and hypertensive heart disease. Foreword. (20937438)
2010
6
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. (19117407)
2009
7
Cardioprotective effect of an L/N-type calcium channel blocker in patients with hypertensive heart disease. (19782264)
2009
8
Cardiac (31)P-MRS compared to echocardiographic findings in patients with hypertensive heart disease without overt systolic dysfunction--preliminary results. (18485651)
2009
9
Plasma lipid peroxidation and totalantioxidant status among dyslipidaemic and hypertensive Nigerians with high risk of coronary heart disease. (19761169)
2009
10
Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction. (17766279)
2007
11
Correlation of uric acid, APO-CIII, and apo-E in healthy individuals and patients with coronary heart disease and hypertensive disease]. (17385437)
2007
12
Identifying a previous myocardial infarction in patients with hypertensive heart disease: lights and shadows. (17586403)
2007
13
Are myocardial fibrosis and diastolic dysfunction reversible in hypertensive heart disease? (16330908)
2005
14
Validation of noncompaction criteria in dilated cardiomyopathy, and valvular and hypertensive heart disease. (16084340)
2005
15
Intramyocardial injection of fibroblast growth factor-2 plus heparin suppresses cardiac failure progression in rats with hypertensive heart disease. (15876812)
2005
16
Early detection of left ventricular diastolic dysfunction in hypertensive heart disease by color Doppler myocardial imaging. (16342344)
2005
17
Analysis of left ventricular systolic function using midwall mechanics in patients >60 years of age with hypertensive heart disease and heart failure. (16253602)
2005
18
Eprosartan improves cardiac performance, reduces cardiac hypertrophy and mortality and downregulates myocardial monocyte chemoattractant protein-1 and inflammation in hypertensive heart disease. (15076165)
2004
19
Hypertension, hypertensive heart disease and perioperative cardiac risk. (15013960)
2004
20
Clinical implications of apoptosis in hypertensive heart disease. (12679323)
2003
21
A role for cardiac mast cells in the pathogenesis of hypertensive heart disease. (14508201)
2003
22
Candesartan cilexetil improves left ventricular function, left ventricular hypertrophy, and endothelial function in patients with hypertensive heart disease. (12419928)
2002
23
Cardiac involvement in autosomal-dominant polycystic kidney disease: a hypertensive heart disease. (11597036)
2001
24
Biochemical assessment of myocardial fibrosis in hypertensive heart disease. (11711527)
2001
25
Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease. (10948081)
2000
26
Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and 'overdrive' of the endothelin system. (10912453)
2000
27
Activating beta-1-adrenoceptor antibodies are not associated with cardiomyopathies secondary to valvular or hypertensive heart disease. (10551705)
1999
28
State of the Art lecture. Risk mechanisms in hypertensive heart disease. (10523361)
1999
29
Hypertensive heart disease with left ventricular diastolic dysfunction demonstrating restrictive hemodynamics: a case report]. (10396707)
1999
30
What is the value of home (self) blood pressure monitoring in patients with hypertensive heart disease? (9683042)
1998
31
Hypertensive heart disease: quantitative evaluation of response to therapy with cine MR imaging. (9288189)
1997
32
The what, why and how of hypertensive heart disease. (7807496)
1994
33
Impact of the daily blood pressure load on the development of hypertensive heart disease. (1301258)
1992
34
Hypertensive heart disease: pathophysiology and clinical and prognostic consequences. (1381796)
1992
35
Predicting hypertensive heart disease via non-invasive methodology: relationship between ambulatory blood pressure and cardiac indices derived by echocardiography and radionuclide ventriculography. (2150531)
1990
36
Nonvalvular atrial fibrillation associated with cardioembolic stroke: the role of hypertensive heart disease. (2140506)
1990
37
Ventricular arrhythmias in hypertensive heart disease with and without heart failure. (2485016)
1987
38
Therapeutic effects of alpha-hANP on hypertensive heart disease with heart failure and oliguria. (2947785)
1986
39
The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload. (6217955)
1983
40
Pathophysiologic assessment of hypertensive heart disease with echocardiography. (140601)
1977
41
Permanent cardiac pacing as a possible adjunct for the treatment of hypertensive heart disease with bradycardia. (4415020)
1974
42
The myocardium in sudden death from hypertensive heart disease or aortic stenosis. (4787066)
1973
43
Effect of propranolol on left atrial systole in ischaemic and hypertensive heart disease. (6020821)
1967
44
Hypertension and hypertensive heart disease. (4226083)
1966
45
Hypertensive heart disease. (13933034)
1963
46
Chronic cor pulmonale or chronic pulmonary hypertensive heart disease? (13960365)
1963
47
Workman's compensation for the cardiac. Physical strain in a case of hypertensive heart disease. (14039272)
1961
48
The frequency of arteriosclerotic and hypertensive heart disease among ostensibly healthy working populations in Finland. An electrocardiographic and clinical study. (13739834)
1961
49
Congenital dextrocardia with situs inversus complicated by hypertensive heart disease; reversal of hypertensive changes following thoracolumbar sympathectomy. (18119902)
1949
50
Hypertensive heart disease. (18132577)
1949

Genetic Variations for Hypertensive Heart Disease

Expression for genes affiliated with Hypertensive Heart Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for genes affiliated with Hypertensive Heart Disease

Sources:
50PharmGKB, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CYP11B2, NR3C2
29.9AGT, CTF1
39.9MMP1, CD36, PPARA

Compounds for genes affiliated with Hypertensive Heart Disease

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1captopril45 29 50 60 1114.5CD36, NR3C2
2hydralazine45 50 1112.4CYP11B2
3cycloheximide4510.4ADCY10
4trandolapril45 1111.1ACE, AGTR1, NPPA, NPPB
5fosinopril45 1111.1ACE, AGTR1, NPPA, NPPB
6ramipril45 1111.0NPPB, NPPA, ACE, AGTR1
7pd12331945 2911.0AGT, AGTR1, CD36, ACE
8eplerenone45 60 29 1113.0NR3C2, ACE, CYP11B2, AGTR1
9benazepril45 1111.0ACE, AGT, NPPA, AGTR1
10aldosterone29 11 2411.9NR3C2, NPPB, AGTR1, CYP11B2
11nitroglycerin45 1110.9AGTR1, ACE, NPPA, NPPB, NPR1
12enalaprilat459.9NPPB, ACE, AGT, NPPA
138-bromo cgmp459.8NPPB, NPPA, AGT, NPR1
14telmisartan45 29 1111.8NPPB, ACE, AGT, AGTR1, PPARA
15lisinopril45 11 2411.8NPPB, ACE, AGT, AGTR1, NPPA
16perindopril45 50 1111.8NPPA, ACE, AGT, NPPB, AGTR1
17candesartan45 29 1111.8NPPB, MMP1, AGT, AGTR1, ACE
18valsartan45 60 29 1112.8AGT, ACE, AGTR1, NPPB
19nitrendipine45 50 29 1112.8ACE, AGTR1, CACNA1B, NPPA
20enalapril45 50 1111.8AGT, AGTR1, NPPA, ACE, NPPB
21atenolol45 29 50 11 2413.8AGTR1, NPPB, AGT, CYP11B2, ACE
22hydrochlorothiazide45 50 29 11 2413.7ACE, AGTR1, NR3C2, AGT, CYP11B2
23spironolactone50 45 60 29 1113.7NPPB, CYP11B2, NPPA, NR3C2, ACE, AGTR1
24felodipine45 29 1111.7NPPA, NR3C2, ACE, AGTR1
25cyclosporin a45 29 6011.7NR3C2, MMP1, ANXA5, NPPB, TIMP2
26amlodipine45 50 11 2412.6AGT, CACNA1B, NPPA, NPPB, AGTR1, ACE
27pioglitazone45 50 29 1112.5PPARA, CD36, NPPB, MMP1, TIMP2
28irbesartan45 29 50 1112.5AGT, ACE, CYP11B2, AGTR1
29norepinephrine45 11 2411.5CACNA1B, PPARA, NR3C2, CYP11B2, MMP1, ADCY10
30guanylate459.4NPPA, AGTR1, NPPB, AGT, ADCY10, NPR1
31nifedipine45 50 29 1112.4CYP11B2, NPPA, CACNA1B, AGTR1, AGT, ACE
32cgmp45 2910.4NPR1, AGT, AGTR1, NPPA, NPPB, ADCY10
33dopamine45 29 11 2412.3AGT, CACNA1B, NR3C2, AOC3, NPPB, AGTR1
34prostacyclin459.3AGTR1, PPARA, ADCY10, NPPA, NPPB, AGT
35ang ii459.2ACE, CYP11B2, CD36, AGT, NPPB, NPPA
36sb 20358045 6010.2ANXA5, MMP1, CD36, NPPB, AGT, AGTR1
37haloperidol45 29 2 50 1113.1AGTR1, AGT, NR3C2, NPPA, NPPB, CACNA1B
38dexamethasone45 50 29 1112.1NR3C2, PPARA, NPPB, ANXA5, AGT, ADCY10
39actinomycin d458.9PPARA, NR3C2, AGTR1, AGT, TIMP2, ANXA5
40sodium45 249.9CACNA1B, NPR1, NPPB, CYP11B2, NR3C2, NPPA
41epinephrine45 11 2410.8AGTR1, NPPA, MMP1, CACNA1B, NPPB, AOC3
42vegf458.8AGTR1, AGT, ANXA5, CD36, MMP1, NPPB
43genistein45 29 60 2 11 2413.8MMP1, TIMP2, PPARA, ANXA5, AGT, NPPB
44losartan45 50 29 1111.7CD36, NPPA, NPPB, MMP1, NR3C2, AGTR1
45creatinine458.6PPARA, NPPA, NPPB, TIMP2, CD36, AOC3
46potassium45 11 2410.6ACE, AGT, AGTR1, NR3C2, CYP11B2, NPPA
47cholesterol45 29 11 2411.5ACE, CYP11B2, AGT, AGTR1, NR3C2, AOC3
48nitric oxide45 11 2410.5CYP11B2, AGT, AGTR1, NR3C2, TIMP2, AOC3
49h2o2458.3AGTR1, AOC3, AGT, ANXA5, MMP1, CD36
50calcium45 50 11 2410.1MMP1, ANXA5, CD36, ACE, ADCY10, AGTR1

GO Terms for genes affiliated with Hypertensive Heart Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1ACE, AGT, CTF1, NPPA, NPPB, TIMP2
2extracellular regionGO:0055768.2ACE, TIMP2, NPPB, NPPA, CTF1, AGT

Biological processes related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3ACE, AGTR1
2cGMP biosynthetic processGO:00618210.3NPPA, NPR1, NPPB
3regulation of vascular permeabilityGO:04311410.3NPPB, NPR1
4receptor guanylyl cyclase signaling pathwayGO:00716810.3NPR1, NPPB, NPPA
5positive regulation of NAD(P)H oxidase activityGO:03386410.3AGTR1, AGT
6regulation of blood vessel sizeGO:05088010.3NPR1, NPPB, NPPA
7regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
8body fluid secretionGO:00758910.3NPR1, NPPB
9regulation of renal output by angiotensinGO:00201910.2ACE, AGT
10regulation of renal sodium excretionGO:03581310.2AGT, AGTR1
11renin-angiotensin regulation of aldosterone productionGO:00201810.2AGT, AGTR1
12positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
13positive regulation of renal sodium excretionGO:03581510.2NPPB, NPR1, AGT
14positive regulation of urine volumeGO:03581010.1NPPB, NPR1
15positive regulation of macrophage derived foam cell differentiationGO:01074410.1AGTR1, AGT, CD36
16regulation of vasodilationGO:04231210.1NPPB, ACE, NPR1, AGTR1
17positive regulation of reactive oxygen species metabolic processGO:200037910.1AGT, CD36, AGTR1
18regulation of vasoconstrictionGO:01922910.1ACE, AGT, AGTR1
19low-density lipoprotein particle remodelingGO:03437410.0AGT, AGTR1
20negative regulation of cell growthGO:0303089.9NPR1, AGT, NPPA, NPPB
21positive regulation of MAPK cascadeGO:0434109.9AGT, TIMP2, CD36
22positive regulation of cellular protein metabolic processGO:0322709.9AGTR1, AGT
23regulation of blood pressureGO:0082179.8NPPA, NPPB, NPR1, CACNA1B, ACE
24kidney developmentGO:0018229.8AGT, AGTR1, ACE
25angiotensin maturationGO:0020039.6AGT, ACE

Molecular functions related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.9AGT, AGTR1
2bradykinin receptor bindingGO:0317119.8ACE, AGTR1
3hormone activityGO:0051799.8AGT, NPPA, NPPB

Products for genes affiliated with Hypertensive Heart Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertensive Heart Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet