Hypertensive Heart Disease malady

Wikipedia: Hypertensive heart disease includes a number of complications of systemic arterial hypertension or high...⁴⁴ more...

MalaCards: Hypertensive Heart Disease is related to hypertension and hypertrophic cardiomyopathy. An important gene associated with Hypertensive Heart Disease is NPR1 (natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and PPAR signaling pathway. The compounds nitroglycerin and atenolol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and tongue, and related mouse phenotypes are immune system and adipose tissue.

Disease Ontology: A heart disease that is caused by high blood presure.⁶

Aliases & Descriptions:

hypertensive heart disease 6 32 43

Diseases related to hypertensive heart disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 269)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	34.9	CYP11B2, ACE, AGT, AGTR1
2	hypertrophic cardiomyopathy	25.8	CD36, ANXA5, TPM1, CYP11B2, NR3C2, ACE
3	atrial fibrillation	25.6	CD36, MMP1, MMP9, CYP11B2, NR3C2, ACE
4	fibrosis	25.4	CD36, MMP1, MMP9, ANXA5, CYP11B2, PPARA
5	aldosteronism	24.4	CD36, MMP1, MMP9, CYP11B2, NR3C2, ACE
6	central sleep apnea	13.5	NPPA, NPPB
7	localized scleroderma	13.4	CD36, MMP1
8	epidermolysis bullosa dystrophica	13.4	CD36, MMP1
9	mitral valve stenosis	13.4	NPPA, NPPB
10	mitral valve insufficiency	13.4	NPPA, NPPB
11	alcoholic cardiomyopathy	13.4	PPARA, ACE
12	fibromatosis, gingival	13.3	CD36, MMP1
13	endocardial fibroelastosis	13.3	NPPA, NPPB
14	renovascular hypertension	13.3	ACE, AGTR1, NPPA
15	short limb dwarf edema iris coloboma	13.3	PPARA, NPPA, NPPB
16	chronic ulcer of skin	13.3	CD36, MMP1
17	autoimmune myocarditis	13.3	PPARA, AGTR1, NPPA
18	ureteral obstruction	13.2	CD36, NR3C2, AGTR1
19	nephrosclerosis	13.2	NR3C2, ACE, AGTR1
20	cardiac rupture	13.2	MMP9, NPPB
21	gingival overgrowth	13.2	CD36, MMP1, ACE
22	familial hyperaldosteronism	13.1	CYP11B2, AGTR1
23	pulmonary embolism	13.1	ACE, NPPA, NPPB
24	diabetes insipidus	13.1	ACE, AGTR1, NPPA
25	renal tubular dysgenesis	13.1	ACE, AGT, AGTR1
26	primary pulmonary hypertension	13.1	ACE, NPPA, NPPB
27	glucocorticoid-remediable aldosteronism	13.1	CYP11B2, NR3C2
28	posterior urethral valves	13.1	ACE, AGT, AGTR1
29	fibromuscular dysplasia	13.1	ACE, AGT, AGTR1
30	hypoaldosteronism	13.1	CYP11B2, ACE, NPPA
31	ischemic optic neuropathy	13.1	ACE, AGT, AGTR1
32	interstitial nephritis	13.1	ACE, AGT, AGTR1
33	diabetes, type 2	13.1	ACE, AGT, AGTR1
34	cor pulmonale	13.1	ACE, AGTR1, NPPA, NPPB
35	membranous glomerulonephritis	13.1	ACE, AGT, AGTR1
36	erythrocytosis	13.0	ACE, AGT, AGTR1
37	aortic valve stenosis	13.0	AGT, NPPA, NPPB
38	pulmonary function	13.0	CD36, ACE, AGTR1, NPPA
39	conn's syndrome	13.0	CYP11B2, NR3C2, NPPA
40	odontogenic myxoma	13.0	CD36, MMP1, MMP9
41	vesicoureteral reflux	13.0	ACE, AGT, AGTR1
42	hypokalemia	13.0	CYP11B2, NR3C2, ACE
43	aneurysm disease	13.0	MMP1, MMP9, ACE
44	cerebral aneurysms	13.0	MMP9, AGTR1, NPPA
45	iga glomerulonephritis	13.0	ACE, AGT, AGTR1
46	subacute sclerosing panencephalitis	13.0	MMP9, ACE, AGTR1
47	familial hypertrophic cardiomyopathy	13.0	TPM1, ACE, AGTR1, NPPB
48	periodontitis	12.9	CD36, MMP1, MMP9
49	urethritis	12.9	ACE, AGT, AGTR1
50	vernal keratoconjunctivitis	12.9	CD36, MMP1, MMP9

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypertensive heart disease:

²²

MGI Mouse Phenotypes related to hypertensive heart disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	9.2	NPR1, AGTR1, PPARA, AOC3
2	adipose tissue phenotype	MP:0005375	8.9	CD36, CTF1, PPARA, ACE, AGT
3	muscle phenotype	MP:0005369	8.0	NPR1, NPPB, NPPA, AGT, PPARA, CYP11B2
4	renal/urinary system phenotype	MP:0005367	7.9	NPPA, AGTR1, AGT, ACE, NR3C2, CYP11B2
5	growth/size phenotype	MP:0005378	7.7	AGTR1, AGT, ACE, NR3C2, PPARA, CTF1
6	mortality/aging	MP:0010768	7.3	NPR1, AGTR1, AGT, ACE, NR3C2, CYP11B2
7	homeostasis/metabolism phenotype	MP:0005376	6.8	ADCY10, NPR1, NPPA, AGT, NR3C2, PPARA
8	cardiovascular system phenotype	MP:0005385	5.9	CD36, ADCY10, NPR1, NPPB, NPPA, AGTR1

Articles related to hypertensive heart disease:

(show all 25)

id	Title	Authors	Year	Affiliating Genes
1	Cardiac MRI assessed left ventricular hypertrophy in differentiating hypertensive heart disease from hypertrophic cardiomyopathy att ributable to a sarcomeric gene mutation. (21274714)	Sipola P.... Kuusisto J.	2011	TPM1
2	Alterations in plasma semicarbazide-sensitive amine o xidase activity in hypertensive heart disease with left ventricular systolic dy sfunction. (20391898)	Marinho C.... Bicho M.	2010	AOC3
3	Association of MMP-9 gene polymorphisms with atrial f ibrillation in hypertensive heart disease patients. (19665460)	Gai X.... Huang M.	2009	MMP9
4	Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. (19117407)	Huang M.... He J.	2009	ACE, CYP11B2
5	Cardioprotective effect of an L/N-type calcium channe l blocker in patients with hypertensive heart disease. (19782264)	Kosaka T.... Ito H.	2009	CACNA1B
6	Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction. (17766279)	Ravassa S.... Diez J.	2007	ANXA5
7	Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease. (16371224)	Goikoetxea M.J.... DA-ez J.	2006	PPARA
8	Early recognition and treatment of hypertensive heart disease. (15956824)	Mitchell J.A.... Mehra M.R.	2005	CD36
9	Is plasma cardiotrophin-1 a marker of hypertensive heart disease? (15716706)	Lopez B.... Diez J.	2005	CTF1
10	The use of collagen-derived serum peptides for the cl inical assessment of hypertensive heart disease. (16003166)	LA^pez B.... DA-ez J.	2005	CD36
11	Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists. (15372301)	Nakagawa M.... Saikawa T.	2004	AGTR1
12	Peroxisome proliferator-activated receptor alpha and hypertensive heart disease. (15765888)	Goikoetxea M.J.... DA-ez J.	2004	PPARA
13	Fibrosis in hypertensive heart disease: role of the r enin-angiotensin-aldosterone system. (14871052)	GonzA!lez A.... DA-ez J.	2004	CD36
14	AGT and AT1R gene polymorphism in hypertensive heart disease. (12425365)	Mettimano M.... Savi L.	2002	AGTR1, AGT
15	Candesartan cilexetil improves left ventricular function, left ventricular hypertrophy, and endothelial function in patients with hypertensive heart disease. (12419928)	Isobe N.... Kamiyama H.	2002	NPPB
16	Biochemical assessment of myocardial fibrosis in hypertensive heart disease. (11711527)	LA^pez B.... DA-ez J.	2001	CD36
17	Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease. (11569573)	Dean D.E.... Powers R.H.	2001	ACE
18	Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease. (10948081)	Schwartzkopff B.... Strauer B.E.	2000	ACE
19	Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease. (10758057)	Querejeta R.... DA-ez J.	2000	CD36
20	Hypertensive heart disease with left ventricular diastolic dysfunction demonstrating restrictive hemodynamics: a case report (10396707)	Soeki T.... Tamura Y.	1999	NPPB, NPPA
21	The cardiac beta-adrenoceptor-mediated signaling pathway and its alterations in hypertensive heart disease. (9052886)	Castellano M.... Bohm M.	1997	ADCY10
22	Regulation and role of myocardial collagen matrix rem odeling in hypertensive heart disease. (9433509)	Funck R.C.... Brilla C.G.	1997	MMP1, NR3C2
23	Role of the cardiac renin-angiotensin system in hypertensive heart disease (7498879)	Holmer S.R.... Riegger G.A.	1995	AGTR1
24	Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. (8518539)	Brilla C.G.... Weber K.T.	1993	ACE
25	Hypertensive heart disease--significance of left vent ricular hypertrophy. (1283190)	Schmieder R.E.	1992	ACE

Genes related to hypertensive heart disease according to GeneCards:

(show all 18)

id	Symbol	Description	Score	GeneCards Section Context
1	NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	11.0
2	NPPB	natriuretic peptide B	11.0	Publications
3	AGTR1	angiotensin II receptor, type 1	11.0	Publications
4	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
5	PPARA	peroxisome proliferator-activated receptor alpha	11.0	Publications
6	NPPA	natriuretic peptide A	11.0	Publications
7	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
8	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
9	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.0	Publications
10	CTF1	cardiotrophin 1	11.0	Publications
11	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0	Publications
12	TPM1	tropomyosin 1 (alpha)	11.0	Publications
13	CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	11.0	Publications
14	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
15	ANXA5	annexin A5	11.0	Publications
16	CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	11.0	Publications
17	ADCY10	adenylate cyclase 10 (soluble)	11.0	Publications
18	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications

Pathways related to hypertensive heart disease according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.0	NR3C2, AGTR1
2	PPAR signaling pathway20	9.7	CD36, MMP1, PPARA
3	Renin-angiotensin system20	9.2	ACE, AGT, AGTR1
4	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	8.7	AGTR1, AGT, ACE, NR3C2, CYP11B2

Compounds related to hypertensive heart disease according to GeneDecks:

(show top 50)    (show all 190)

id	Compound	Score	Top Affiliating Genes
1	nitroglycerin32 9 9	12.6	NPR1
2	atenolol32 9 18 9	13.5	CYP11B2
3	guanylate32	10.4	NPPB, NPR1
4	trandolapril32 9 9	11.9	ACE, AGTR1, NPPA, NPPB
5	ramipril32 9 9	11.7	NPPA, NPPB, AGTR1, ACE
6	pd12331932	9.6	AGT, ACE, CD36, AGTR1
7	benazepril32 9 9	11.6	AGTR1, NPPA, AGT, ACE
8	eplerenone32 42 9 9	12.6	AGTR1, ACE, NR3C2, CYP11B2
9	enalaprilat32	9.6	AGT, NPPB, NPPA, ACE
10	Aldosterone9 18 9	11.6	AGTR1, NR3C2, CYP11B2, NPPB
11	lisinopril32 9 18 9	12.5	ACE, NPPA, AGT, NPPB, AGTR1
12	telmisartan32 9 9	11.5	AGT, PPARA, AGTR1, NPPB, ACE
13	8-bromo cgmp32	9.5	NPPB, NPPA, NPR1, AGT
14	perindopril32 34 9 9	12.5	NPPA, NPPB, AGTR1, AGT, ACE
15	enalapril32 9 9	11.4	NPPB, ACE, NPPA, AGTR1, AGT
16	candesartan32 9 9	11.4	ACE, MMP1, NPPB, AGT, AGTR1
17	fosinopril32 9 9	11.4	ACE, MMP9, AGTR1, NPPA, NPPB
18	captopril32 42 9 9	12.4	NPPB, ACE, NR3C2, AGT, NPPA
19	spironolactone32 42 34 9 9	13.2	CYP11B2, NR3C2, ACE, AGTR1, NPPA, NPPB
20	valsartan32 42 9 9	12.2	AGT, NPPB, AGTR1, ACE
21	chymostatin32	9.2	MMP9, AGTR1, AGT, ACE
22	hydrochlorothiazide32 34 9 18 9	13.2	AGTR1, AGT, ACE, NR3C2, CYP11B2
23	nitrendipine32 9 9	11.1	ACE, CACNA1B, AGTR1, NPPA
24	rosiglitazone32 9 18 9	12.1	CD36, NPPB, PPARA, MMP9, MMP1, AGTR1
25	l-nmma32	9.1	NPPB, NPPA, AGTR1, AGT, MMP9
26	amlodipine32 9 18 9	12.1	AGTR1, AGT, NPPB, CACNA1B, ACE
27	irbesartan32 9 9	11.0	MMP9, ACE, CYP11B2, AGT, AGTR1
28	fluvastatin32 34 9 9	12.0	MMP9, AGTR1, PPARA, ANXA5, MMP1
29	hydralazine32 34 9 9	11.9	AOC3, CYP11B2, ACE, AGTR1
30	cgmp32	8.6	NPPA, AGT, AGTR1, NPR1, ADCY10, NPPB
31	ang ii32	8.6	NR3C2, ACE, CYP11B2, CD36, AGT, AGTR1
32	prostacyclin32	8.4	ACE, NPPB, ADCY10, NPPA, AGTR1, PPARA
33	sb 20358032 42	9.3	MMP1, AGT, ANXA5, AGTR1, CD36, NPPB
34	losartan32 34 9 9	11.3	NPPA, AGTR1, AGT, ACE, NR3C2, CYP11B2
35	sodium32 18	9.2	CACNA1B, NR3C2, CYP11B2, NPR1, NPPB, NPPA
36	haloperidol32 34 9 9	11.2	AGTR1, CYP11B2, NPPB, NR3C2, MMP1, CACNA1B
37	nifedipine32 9 9	10.1	AGT, ACE, CYP11B2, NPPA, CACNA1B, MMP9
38	cyclosporin a32 42	9.1	MMP1, NPPB, AGTR1, AGT, NR3C2, ANXA5
39	nitric oxide32 9 18 9	10.9	NPPB, AGTR1, AOC3, NPR1, CYP11B2, NPPA
40	prostaglandin32	7.9	NPPA, AGTR1, AGT, ADCY10, MMP1, MMP9
41	vegf32	7.8	MMP1, CD36, AGT, AGTR1, NPPA, NPPB
42	creatinine32	7.6	MMP9, MMP1, CD36, PPARA, NPPA, AGTR1
43	dopamine32 9 18 9	10.5	NR3C2, ADCY10, MMP9, AGT, NPPA, AOC3
44	calcium32 9 18 9	10.4	CD36, ANXA5, CYP11B2, AOC3, AGT, AGTR1
45	cycloheximide32	7.4	AGTR1, MMP1, CD36, MMP9, ANXA5, PPARA
46	genistein32 9 18 9	10.4	AGT, PPARA, AGTR1, NPPB, MMP1, CD36
47	pge232	7.3	AGT, MMP1, MMP9, CD36, NPPA, CACNA1B
48	epinephrine32 9 18 9	10.2	AGT, MMP1, MMP9, AOC3, CACNA1B, AGTR1
49	dexamethasone32 42 34 9 9	10.7	CD36, MMP1, MMP9, ANXA5, CYP11B2, PPARA
50	norepinephrine32 9 18 9	9.0	ACE, ADCY10, MMP9, CACNA1B, MMP1, AGT

Biological processes related to hypertensive heart disease according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of vascular permeability	GO:043114	10.2	NPR1, NPPB
2	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	10.2	AGTR1, ACE
3	cGMP biosynthetic process	GO:006182	10.2	NPPA, NPPB, NPR1
4	regulation of blood vessel size	GO:050880	10.2	NPR1, NPPB, NPPA
5	receptor guanylyl cyclase signaling pathway	GO:007168	10.1	NPR1, NPPB, NPPA
6	positive regulation of NAD(P)H oxidase activity	GO:033864	10.1	AGT, AGTR1
7	renin-angiotensin regulation of aldosterone production	GO:002018	10.1	AGT, AGTR1
8	body fluid secretion	GO:007589	10.1	NPR1, NPPB
9	regulation of blood vessel size by renin-angiotensin	GO:002034	10.1	AGT, AGTR1
10	regulation of renal sodium excretion	GO:035813	10.0	AGTR1, AGT
11	regulation of renal output by angiotensin	GO:002019	10.0	ACE, AGT
12	positive regulation of urine volume	GO:035810	10.0	NPPB, NPR1
13	positive regulation of renal sodium excretion	GO:035815	10.0	NPR1, NPPB, AGT
14	positive regulation of cholesterol esterification	GO:010873	9.9	AGTR1, AGT
15	regulation of vasodilation	GO:042312	9.9	ACE, AGTR1, NPPB, NPR1
16	positive regulation of macrophage derived foam cell differentiation	GO:010744	9.9	AGTR1, AGT, CD36
17	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.9	AGTR1, AGT, CD36
18	regulation of blood pressure	GO:008217	9.9	ACE, NPPA, NPPB, NPR1
19	low-density lipoprotein particle remodeling	GO:034374	9.9	AGTR1, AGT
20	regulation of vasoconstriction	GO:019229	9.8	AGTR1, AGT, ACE
21	nitric oxide mediated signal transduction	GO:007263	9.8	CD36, AGT
22	negative regulation of cell growth	GO:030308	9.6	NPR1, NPPB, NPPA, AGT
23	kidney development	GO:001822	9.6	ACE, AGT, AGTR1
24	positive regulation of cellular protein metabolic process	GO:032270	9.5	AGT, AGTR1
25	positive regulation of apoptotic process	GO:043065	8.4	MMP9, ANXA5, AGT, ADCY10

Molecular functions related to hypertensive heart disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	bradykinin receptor binding	GO:031711	9.9	ACE, AGTR1
2	acetyltransferase activator activity	GO:010698	9.8	AGT, AGTR1
3	peptide hormone receptor binding	GO:051428	9.7	NPPA, NPPB
4	hormone activity	GO:005179	9.6	AGT, NPPA, NPPB