MCID: HYP006
MIFTS: 50

Hypertensive Heart Disease malady

Cardiovascular diseases category
Download this MalaCard

Summaries for Hypertensive Heart Disease

About this section


Fully expand this MalaCard
Wikipedia:65 Hypertensive heart disease includes a number of complications of systemic arterial hypertension or high... more...

MalaCards based summary: Hypertensive Heart Disease is related to hypertension and vascular disease. An important gene associated with Hypertensive Heart Disease is NPR1 (natriuretic peptide receptor 1), and among its related pathways are PPAR signaling pathway and Adipocytokine signaling pathway. The compounds urodilatin and gw9662 have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and endothelial, and related mouse phenotypes are immune system and muscle.

Disease Ontology:8 A heart disease that is caused by high blood presure.

Aliases & Classifications for Hypertensive Heart Disease

About this section

Hypertensive Heart Disease, Aliases & Descriptions:

Name: Hypertensive Heart Disease 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:11516
ICD9CM27 402.9, 402
ICD1025 I11, I11.0, I11.9

Related Diseases for Hypertensive Heart Disease

About this section

Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.5PPARA, AGTR1, NPR1, NPPB
2vascular disease30.3AGTR1, PPARA
3cor pulmonale30.2NPPB, AGTR1
4essential hypertension30.1NPPB, AGTR1, NPR1
5hypertrophic cardiomyopathy10.6
6ischemia10.4
7pulmonary hypertension10.2
8diastolic heart failure10.2
9artery disease10.2
10dilated cardiomyopathy10.2
11nephrosclerosis10.2
12amyloidosis10.2
13left ventricular outflow tract obstruction10.2
14endotheliitis10.2
15familial hyperlipidemia10.1AGTR1, PPARA
16idiopathic edema10.1NPPB, PPARA
17hypercholesterolemia10.1PPARA, AGTR1
18osteoporosis10.1CD36
19coronary artery anomaly10.0NPPB, AGTR1
20hyperinsulinism10.0PPARA, AGTR1
21acute myocardial infarction10.0AGTR1, NPPB
22cerebral hemorrhage10.0
23obesity10.0
24fabry disease10.0
25alcoholic cardiomyopathy10.0
26situs inversus10.0
27polycystic kidney disease10.0
28arteriolosclerosis10.0
29dextrocardia10.0
30erythromelalgia10.0
31miliary tuberculosis10.0
32gastric ulcer10.0
33cerebritis10.0
34angioedema10.0
35dermatitis10.0
36kidney disease10.0
37myocarditis10.0
38pyelonephritis10.0
39tuberculosis10.0
40congenital varicella syndrome10.0
41dextrocardia with situs inversus10.0
42renal dysplasia10.0
43renal fibrosis10.0CD36, AGTR1
44glomerulosclerosis10.0CD36, AGTR1
45pulmonary fibrosis10.0CD36, AGTR1
46noonan syndrome10.0AGTR1, NPPB
47congestive heart failure9.9NPR1, AGTR1, NPPB
48cerebrovascular disease9.9NPR1, NPPB, AGTR1
49congenital heart disease9.9PPARA, NPPB, AGTR1
50myocardial infarction9.9NPPB, AGTR1, NPR1

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to hypertensive heart disease

Symptoms for Hypertensive Heart Disease

About this section

Drugs & Therapeutics for Hypertensive Heart Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Hypertensive Heart Disease

Search NIH Clinical Center for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

About this section

Anatomical Context for Hypertensive Heart Disease

About this section

MalaCards organs/tissues related to Hypertensive Heart Disease:

32
Heart, Monocytes, Endothelial, Bone marrow, Bone, Kidney, Testes, Tongue

Animal Models for Hypertensive Heart Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Hypertensive Heart Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2AGTR1, CD36, NPR1, PPARA
2MP:00053697.8PPARA, NPPB, NPR1, CD36
3MP:00053857.4AGTR1, CD36, NPR1, NPPB, PPARA

Publications for Hypertensive Heart Disease

About this section

Articles related to Hypertensive Heart Disease:

(show top 50)    (show all 323)
idTitleAuthorsYear
1
Hypertensive heart disease and obesity: a complex interaction between hemodynamic and not hemodynamic factors. (24821373)
2014
2
Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. (24140724)
2013
3
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease. (23657971)
2013
4
Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities. (22886534)
2013
5
Gene expression profiles of peripheral blood mononuclear cells reveal transcriptional signatures as novel biomarkers of cardiac remodeling in rats with aldosteronism and hypertensive heart disease. (24622010)
2013
6
MRI differentiation of cardiomyopathy showing left ventricular hypertrophy and heart failure: differentiation between cardiac amyloidosis, hypertrophic cardiomyopathy, and hypertensive heart disease. (23996116)
2013
7
Elevated circulating fibrocyte levels in patients with hypertensive heart disease. (22796709)
2012
8
Hypertensive heart disease: bone marrow as a significant player in pathologic remodelling? (22895017)
2012
9
Should African-Americans with elevated blood pressure be routinely screened for hypertensive heart disease? (23190057)
2012
10
Cardiotrophin-1 in hypertensive heart disease. (22418690)
2012
11
Dominance of hypertensive heart disease in a tertiary hospital in southern Nigeria: an echocardiographic study. (22764633)
2012
12
Preface: hypertension and hypertensive heart disease. (20937439)
2010
13
Is Smad3 the key to inflammation and fibrosis in hypertensive heart disease? (20231519)
2010
14
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. (19117407)
2009
15
Influence of the type and degree of left ventricular hypertrophy on the prevalence of ventricular arrhythmias in patients with hypertensive heart disease. (18936895)
2008
16
Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction. (17766279)
2007
17
31P-MR spectroscopic imaging in hypertensive heart disease. (16514468)
2006
18
Are myocardial fibrosis and diastolic dysfunction reversible in hypertensive heart disease? (16330908)
2005
19
New directions in the assessment and treatment of hypertensive heart disease. (16046900)
2005
20
Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists. (15372301)
2004
21
Monocyte chemoattractant protein-1: a key mediator of angiotensin II-induced target organ damage in hypertensive heart disease? (15076146)
2004
22
Clinical implications of apoptosis in hypertensive heart disease. (12679323)
2003
23
Candesartan cilexetil improves left ventricular function, left ventricular hypertrophy, and endothelial function in patients with hypertensive heart disease. (12419928)
2002
24
Cardioreparation in hypertensive heart disease. (11566936)
2001
25
Behavioral treatment of hypertensive heart disease in African Americans: rationale and design of a randomized controlled trial. (11763829)
2001
26
Cardiac involvement in autosomal-dominant polycystic kidney disease: a hypertensive heart disease. (11597036)
2001
27
Ischemia and fibrosis: the risk mechanisms of hypertensive heart disease. (10829097)
2000
28
Regression of myocardial fibrosis in hypertensive heart disease: diverse effects of various antihypertensive drugs. (10773237)
2000
29
Indicators and treatment of hypertensive heart disease. (10901763)
1999
30
Hypertensive heart disease. (10652906)
1999
31
Hypertensive heart disease, ventricular dysrhythmias, and sudden death. (9433533)
1997
32
Modulation of hypertensive heart disease by estrogen. (8733001)
1996
33
Diabetic and hypertensive heart disease. (8678395)
1996
34
Coronary microcirculation in hypertensive heart disease: functional significance and therapeutic implications. (8518540)
1993
35
Coronary haemodynamics in hypertensive heart disease. (1396859)
1992
36
Development of cardiac failure by coronary small vessel disease in hypertensive heart disease? (1838764)
1991
37
Coronary vascular changes in the progression and regression of hypertensive heart disease. (1720480)
1991
38
Predicting hypertensive heart disease via non-invasive methodology: relationship between ambulatory blood pressure and cardiac indices derived by echocardiography and radionuclide ventriculography. (2150531)
1990
39
Hypertensive heart disease: relationship of silent ischemia to coronary artery disease and left ventricular hypertrophy. (2145735)
1990
40
Comparative analysis of cardiac function, geometry, energetics and coronary reserve in hypertensive heart disease. (2962004)
1987
41
Usefulness of stress testing for the evaluation of hypertensive heart disease in young hypertensive subjects. (6488227)
1984
42
The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload. (6217955)
1983
43
Ischemic and hypertensive heart disease in the aged: prognostic and therapeutic factors. (7410762)
1980
44
Diastolic time intervals in ischemic and hypertensive heart disease: A comparison of isovolumic relaxation time and rapid filling time with systolic time intervals. (1149531)
1975
45
Clinical-physiological correlations in the development of hypertensive heart disease. (4255490)
1971
46
Prognosis of hypertensive heart disease. (13339176)
1956
47
Hypertensive heart disease, a confusing term; pathogenic considerations. (13274389)
1955
48
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
49
Recent trends in hypertensive heart disease. (15399041)
1950
50
Hypertensive heart disease; case report. (21004782)
1945

Variations for Hypertensive Heart Disease

About this section

Expression for genes affiliated with Hypertensive Heart Disease

About this section
Expression patterns in normal tissues for genes affiliated with Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for genes affiliated with Hypertensive Heart Disease

About this section

Pathways related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.1CD36, PPARA
29.1CD36, PPARA

Compounds for genes affiliated with Hypertensive Heart Disease

About this section

Compounds related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1urodilatin449.8NPR1, NPPB
2gw966244 2810.8AGTR1, PPARA
38-bromo cgmp449.7NPPB, NPR1
4trandolapril44 1110.7NPPB, AGTR1
5fosinopril44 1110.7NPPB, AGTR1
6lisinopril44 50 24 1112.7NPPB, AGTR1
7ramipril44 1110.7AGTR1, NPPB
8aldosterone28 24 1111.7AGTR1, NPPB
9valsartan44 61 28 1112.7AGTR1, NPPB
10perindopril44 50 1111.6AGTR1, NPPB
11atenolol44 50 28 24 1113.6NPPB, AGTR1
12amiodarone44 50 28 1112.6PPARA, NPPB
13candesartan44 50 28 1112.6NPPB, AGTR1
14enalapril44 50 1111.6AGTR1, NPPB
15amlodipine44 50 24 1112.6AGTR1, NPPB
16spironolactone44 61 28 50 1113.5AGTR1, NPPB
17pd12331944 2810.5CD36, AGTR1
18carvedilol44 50 28 1112.5NPPB, AGTR1
198-isoprostane449.4NPPB, AGTR1
20p005449.3NPPB, AGTR1
21nitroglycerin44 1110.3AGTR1, NPR1, NPPB
22sodium nitroprusside449.3NPPB, NPR1, AGTR1
23guanylate449.3AGTR1, NPR1, NPPB
24cgmp44 2810.3AGTR1, NPR1, NPPB
25telmisartan44 28 1111.3PPARA, NPPB, AGTR1
26digoxin44 61 50 24 1113.2NPPB, AGTR1
27pravastatin44 50 28 24 1113.2AGTR1, NPPB, PPARA
28prostacyclin449.2AGTR1, NPPB, PPARA
29aspirin44 50 28 2412.2AGTR1, NPPB, PPARA
30norepinephrine44 24 1111.1AGTR1, NPPB, PPARA
31actinomycin d449.1AGTR1, NPPB, PPARA
32furosemide44 61 28 50 24 1114.0AGTR1, NPPB
33forskolin44 50 1111.0AGTR1, NPR1, NPPB
34ang ii448.9NPPB, CD36, AGTR1
35captopril44 61 50 28 1112.9NPPB, CD36, AGTR1
36pioglitazone28 44 50 1111.9PPARA, NPPB, CD36
37losartan44 50 28 1111.9AGTR1, CD36, NPPB
38sodium44 249.9AGTR1, NPR1, NPPB
39sb 20358044 619.8AGTR1, CD36, NPPB
40pge2448.6CD36, NPPB, PPARA
41rosiglitazone28 44 50 24 1112.4PPARA, NPPB, CD36, AGTR1
42tacrolimus44 50 1110.4AGTR1, CD36, NPPB, PPARA
43cysteine448.4AGTR1, CD36, NPR1, NPPB
44genistein44 28 61 2 24 1113.4AGTR1, CD36, NPPB, PPARA
45creatinine448.4PPARA, NPPB, CD36, AGTR1
46dexamethasone44 50 28 1111.4PPARA, NPPB, CD36, AGTR1
47vegf448.4PPARA, NPPB, CD36, AGTR1
48vitamin d448.0AGTR1, CD36, NPR1, NPPB, PPARA
49estrogen448.0PPARA, NPPB, NPR1, CD36, AGTR1
50serine448.0PPARA, NPPB, NPR1, CD36, AGTR1

GO Terms for genes affiliated with Hypertensive Heart Disease

About this section

Cellular components related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7AGTR1, CD36, NPR1

Biological processes related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of vascular permeabilityGO:0431149.7NPR1, NPPB
2cGMP biosynthetic processGO:0061829.7NPR1, NPPB
3body fluid secretionGO:0075899.7NPR1, NPPB
4receptor guanylyl cyclase signaling pathwayGO:0071689.6NPR1, NPPB
5positive regulation of urine volumeGO:0358109.6NPR1, NPPB
6regulation of blood vessel sizeGO:0508809.6NPPB, NPR1
7positive regulation of renal sodium excretionGO:0358159.6NPPB, NPR1
8negative regulation of angiogenesisGO:0165259.5NPR1, NPPB
9regulation of blood pressureGO:0082179.4NPPB, NPR1
10positive regulation of macrophage derived foam cell differentiationGO:0107449.3AGTR1, CD36
11positive regulation of reactive oxygen species metabolic processGO:20003799.2AGTR1, CD36
12regulation of vasodilationGO:0423129.2AGTR1, NPR1, NPPB
13cellular lipid metabolic processGO:0442559.1CD36, PPARA
14negative regulation of cell growthGO:0303089.1NPR1, NPPB
15lipid metabolic processGO:0066299.0CD36, PPARA
16cell surface receptor signaling pathwayGO:0071668.8NPPB, NPR1, CD36

Molecular functions related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:0082899.1CD36, PPARA

Products for genes affiliated with Hypertensive Heart Disease

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Hypertensive Heart Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet