MCID: HYP006
MIFTS: 56

Hypertensive Heart Disease malady

Cardiovascular diseases category

Summaries for Hypertensive Heart Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertensive heart disease includes a number of complications of systemic arterial hypertension or high... more...

MalaCards: Hypertensive Heart Disease is related to hypertension and hypertrophic cardiomyopathy. An important gene associated with Hypertensive Heart Disease is NPR1 (natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The compounds captopril and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and lung, and related mouse phenotypes are muscle and renal/urinary system.

Disease Ontology:8 A heart disease that is caused by high blood presure.

Aliases & Classifications for Hypertensive Heart Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Related Diseases for Hypertensive Heart Disease

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17GeneCards, 18GeneDecks
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Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8NPR1, AGTR1, AGT, PPARA, CYP11B2, NPPA
2hypertrophic cardiomyopathy30.9TPM1
3ischemia30.6NPPB, CTF1, PPARA, NR3C2, AGT
4ischemic heart disease30.5NPPA, CTF1, ACE, AGTR1, AGT, NPPB
5vascular disease30.4ANXA5, TIMP2
6coronary artery disease30.3PPARA, ACE, AGT, AGTR1, NPPA, NPPB
7dilated cardiomyopathy30.3ADCY10, TPM1, ACE, MMP1, NPPB, NPPA
8nephrosclerosis30.2NR3C2, ACE, AGTR1
9essential hypertension30.2CACNA1B, NPR1, NPPB, NPPA, NR3C2, AGTR1
10dermatitis30.0PPARA
11myocarditis30.0NPPB
12myocardial infarction30.0AGT, ANXA5, CYP11B2, ACE, NPR1, NPPB
13collagen disease10.4
14systolic heart failure10.2
15diastolic heart failure10.2
16renal hypertension10.2
17amyloidosis10.2
18aortic disease10.2
19peroxisomal disease10.2
20vein disease10.2
21cerebritis10.0
22arteriolosclerosis10.0
23heart lymphoma10.0
24dextrocardia10.0
25gastric ulcer10.0
26alcoholic cardiomyopathy10.0
27erythromelalgia10.0
28miliary tuberculosis10.0
29situs inversus10.0
30polycystic kidney disease10.0
31fabry disease10.0
32acute pulmonary heart disease10.0
33angioedema10.0
34autosomal dominant disease10.0
35bone remodeling disease10.0
36cerebral arterial disease10.0
37chronic pulmonary heart disease10.0
38glucose metabolism disease10.0
39hemorrhagic disease10.0
40kidney disease10.0
41pyelonephritis10.0
42tongue disease10.0
43tuberculosis10.0
44polycystic kidney disease, autosomal dominant10.0
45mitral valve prolapse10.0AGTR1
46mitral valve disease10.0NPPA
47otosclerosis10.0CD36
48anuria10.0ACE
49glomerulonephritis10.0AGTR1
50gingivitis10.0MMP1

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to hypertensive heart disease

Clinical Features for Hypertensive Heart Disease

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Drugs & Therapeutics for Hypertensive Heart Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypertensive Heart Disease

Drug clinical trials:

Search ClinicalTrials for Hypertensive Heart Disease

Search NIH Clinical Center for Hypertensive Heart Disease

Search CenterWatch for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

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Anatomical Context for Hypertensive Heart Disease

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32MalaCards
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MalaCards organs/tissues related to Hypertensive Heart Disease:

32
Heart, Endothelial, Lung, Kidney, Testes, Monocytes, Bone marrow, Spinal cord, Bone, Tongue

Animal Models for Hypertensive Heart Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertensive Heart Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0CYP11B2, CD36, PPARA, NPPA, NPPB, AGT
2MP:00053678.8NPPA, NR3C2, AGTR1, AGT, CD36, CYP11B2
3MP:00053878.3CD36, NPR1, PPARA, AOC3, AGTR1, AGT
4MP:00053787.9CACNA1B, AGTR1, AGT, CD36, CYP11B2, ACE
5MP:00053857.3TPM1, CACNA1B, NPR1, NPPB, NPPA, PPARA
6MP:00053767.2CTF1, PPARA, NR3C2, AGTR1, AGT, CYP11B2

Publications for Hypertensive Heart Disease

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50PubMed
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Articles related to Hypertensive Heart Disease:

(show top 50)    (show all 430)
idTitleAuthorsYear
1
Prevalence and correlates of self-reported medication non-adherence among older adults with coronary heart disease, diabetes mellitus, and/or hypertension. (23291338)
2013
2
Atrophic cardiomyocyte signaling in hypertensive heart disease. (24084216)
2013
3
Markers of inflammation, endothelial activation, and arterial stiffness in hypertensive heart disease and the effects of treatment: results from the SILVHIA study. (24084214)
2013
4
Association between I^-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension. (22941975)
2012
5
Validation and psychometric properties of Chinese version of SF-36 in patients with hypertension, coronary heart diseases, chronic gastritis and peptic ulcer. (22994333)
2012
6
Mechanisms of pulmonary hypertension related to ventricular septal defect in congenital heart disease. (22035778)
2011
7
Diltiazem in the treatment of hypertension and ischemic heart disease. (22059786)
2011
8
Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. (20823713)
2010
9
Autophagy in hypertensive heart disease. (20118246)
2010
10
Platelet aggregation and endothelial function in patients with complicated essential hypertension (ischemic stroke) and coronary heart disease. (21113448)
2010
11
Distribution of left ventricular ejection fraction in patients with ischemic and hypertensive heart disease and chronic heart failure. (19892060)
2009
12
Cardioprotective effect of an L/N-type calcium channel blocker in patients with hypertensive heart disease. (19782264)
2009
13
Plasma lipid peroxidation and totalantioxidant status among dyslipidaemic and hypertensive Nigerians with high risk of coronary heart disease. (19761169)
2009
14
Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. (19628115)
2009
15
Enhanced detection of genetic association of hypertensive heart disease by analysis of latent phenotypes. (18435473)
2008
16
Diagnosis and treatment of myocardial fibrosis in hypertensive heart disease. (18772529)
2008
17
Effect of atorvastatin on endothelial function and inflammation in long-duration type 1 diabetic patients without coronary heart disease and arterial hypertension. (17941871)
2008
18
Changes of the levels of adrenomedulin, endothelin-1 and nitric oxide in children with pulmonary hypertension secondary to congenital heart disease]. (18211765)
2007
19
Pulmonary arterial hypertension in adults born with a heart septal defect: the Euro Heart Survey on adult congenital heart disease. (17164490)
2007
20
Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. (17377073)
2007
21
Impaired apoptosis of pulmonary endothelial cells is associated with intimal proliferation and irreversibility of pulmonary hypertension in congenital heart disease. (17306711)
2007
22
Extracellular matrix remodeling in hypertensive heart disease. (16814654)
2006
23
Expression and pathological implication of transforming growth factor-beta1 mRNA and endothelin-1 mRNA in intraacinar pulmonary arterioles of congenital heart disease accompanied with pulmonary hypertension]. (15938827)
2005
24
Apolipoprotein B100 as a risk factor of acute coronary syndrome and this risk factor effect on arterial hypertension in patients with ischemic heart disease]. (16281487)
2005
25
Hypertensive heart disease and fibrosis. (15218391)
2004
26
Quantification of D-dimer and soluble fibrin in blood plasma of people with ischemic heart disease and hypertension]. (16350758)
2004
27
Calcium antagonists in the treatment of hypertension in patients with ischaemic heart disease. (12943483)
2003
28
Coronary heart disease, hypertension, and angiotensinogen gene variants in Indian population. (12938141)
2003
29
Rationale of echocardiographic assessment of left ventricular wall stress and midwall mechanics in hypertensive heart disease. (12144838)
2002
30
Behavioral treatment of hypertensive heart disease in African Americans: rationale and design of a randomized controlled trial. (11763829)
2001
31
Other diseases with diastolic dysfunction: how to deal with? Hypertensive heart disease. (10582462)
1999
32
Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited. (10459563)
1999
33
The relationship between angiotensin II type 1 receptor gene and coronary heart disease, hypertension and diabetes mellitus in Chinese]. (9456365)
1998
34
Hypertensive heart disease syndrome in women in a cardiology practice. (9283740)
1997
35
A symposium: progress in hypertensive heart disease: microangiopathy, molecular and cellular biology, cardiac arrhythmias, and heart failure. February 23-24, 1995, Bilbao, Spain. Proceedings. (7495210)
1995
36
Progressive intraventricular drop of early diastolic flow velocity reflects impaired active ventricular diastolic function in hypertensive heart disease: comparative study between early diastolic and atrial contraction phases. (9417208)
1995
37
Correction of left ventricular ischemia in blacks with hypertensive heart disease. (8398011)
1993
38
Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. (8518539)
1993
39
Functional and organic components of diastolic dysfunction in hypertensive heart disease: therapeutic implications. (8281953)
1993
40
Coronary haemodynamics in hypertensive heart disease. (1396859)
1992
41
Isolated myocardial cells: a new tool for the investigation of hypertensive heart disease. (2147954)
1990
42
Effects of antihypertensive therapy on hypertensive heart disease. (2532079)
1989
43
Comparative analysis of cardiac function, geometry, energetics and coronary reserve in hypertensive heart disease. (2962004)
1987
44
Hypertensive heart disease and endocardially recorded late potentials. (2485017)
1987
45
Ischemic and hypertensive heart disease in the aged: prognostic and therapeutic factors. (7410762)
1980
46
Hypertensive heart disease and cardiomyopathy in blacks. Diagnostic confusion. (451782)
1979
47
Pathophysiology and biochemistry of end-stage hypertensive heart disease. (4286892)
1966
48
Biochemical versus hemodynamic factors in the origin of hypertensive heart disease. (15432146)
1950
49
Hypertensive heart disease. (20289838)
1947
50
The reversibility of hypertensive heart disease by lumbodorsal sympathectomy. (20277847)
1946

Genetic Variations for Hypertensive Heart Disease

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Expression for genes affiliated with Hypertensive Heart Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for genes affiliated with Hypertensive Heart Disease

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49PharmGKB, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CYP11B2, NR3C2
29.9AGT, CTF1
39.9MMP1, CD36, PPARA

Compounds for genes affiliated with Hypertensive Heart Disease

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.5CD36, NR3C2
2hydralazine44 49 1112.4CYP11B2
3cycloheximide4410.4ADCY10
4trandolapril44 1111.1ACE, AGTR1, NPPA, NPPB
5fosinopril44 1111.1ACE, AGTR1, NPPA, NPPB
6ramipril44 1111.0NPPB, NPPA, ACE, AGTR1
7pd12331944 2811.0AGT, AGTR1, CD36, ACE
8eplerenone44 59 28 1113.0NR3C2, ACE, CYP11B2, AGTR1
9benazepril44 1111.0ACE, AGT, NPPA, AGTR1
10aldosterone28 11 2411.9NR3C2, NPPB, AGTR1, CYP11B2
11nitroglycerin44 1110.9AGTR1, ACE, NPPA, NPPB, NPR1
12enalaprilat449.9NPPB, ACE, AGT, NPPA
138-bromo cgmp449.8NPPB, NPPA, AGT, NPR1
14telmisartan44 28 1111.8NPPB, ACE, AGT, AGTR1, PPARA
15lisinopril44 11 2411.8NPPB, ACE, AGT, AGTR1, NPPA
16perindopril44 49 1111.8NPPA, ACE, AGT, NPPB, AGTR1
17candesartan44 28 1111.8NPPB, MMP1, AGT, AGTR1, ACE
18valsartan44 59 28 1112.8AGT, ACE, AGTR1, NPPB
19nitrendipine44 49 28 1112.8ACE, AGTR1, CACNA1B, NPPA
20enalapril44 49 1111.8AGT, AGTR1, NPPA, ACE, NPPB
21atenolol44 28 49 11 2413.8AGTR1, NPPB, AGT, CYP11B2, ACE
22hydrochlorothiazide44 49 28 11 2413.7ACE, AGTR1, NR3C2, AGT, CYP11B2
23spironolactone49 44 59 28 1113.7NPPB, CYP11B2, NPPA, NR3C2, ACE, AGTR1
24felodipine44 28 1111.7NPPA, NR3C2, ACE, AGTR1
25cyclosporin a44 28 5911.7NR3C2, MMP1, ANXA5, NPPB, TIMP2
26amlodipine44 49 11 2412.6AGT, CACNA1B, NPPA, NPPB, AGTR1, ACE
27pioglitazone44 49 28 1112.5PPARA, CD36, NPPB, MMP1, TIMP2
28irbesartan44 28 49 1112.5AGT, ACE, CYP11B2, AGTR1
29norepinephrine44 11 2411.5CACNA1B, PPARA, NR3C2, CYP11B2, MMP1, ADCY10
30guanylate449.4NPPA, AGTR1, NPPB, AGT, ADCY10, NPR1
31nifedipine44 49 28 1112.4CYP11B2, NPPA, CACNA1B, AGTR1, AGT, ACE
32cgmp44 2810.4NPR1, AGT, AGTR1, NPPA, NPPB, ADCY10
33dopamine44 28 11 2412.3AGT, CACNA1B, NR3C2, AOC3, NPPB, AGTR1
34prostacyclin449.3AGTR1, PPARA, ADCY10, NPPA, NPPB, AGT
35ang ii449.2ACE, CYP11B2, CD36, AGT, NPPB, NPPA
36sb 20358044 5910.2ANXA5, MMP1, CD36, NPPB, AGT, AGTR1
37haloperidol44 28 2 49 1113.1AGTR1, AGT, NR3C2, NPPA, NPPB, CACNA1B
38dexamethasone44 49 28 1112.1NR3C2, PPARA, NPPB, ANXA5, AGT, ADCY10
39actinomycin d448.9PPARA, NR3C2, AGTR1, AGT, TIMP2, ANXA5
40sodium44 249.9CACNA1B, NPR1, NPPB, CYP11B2, NR3C2, NPPA
41epinephrine44 11 2410.8AGTR1, NPPA, MMP1, CACNA1B, NPPB, AOC3
42vegf448.8AGTR1, AGT, ANXA5, CD36, MMP1, NPPB
43genistein44 28 59 2 11 2413.8MMP1, TIMP2, PPARA, ANXA5, AGT, NPPB
44losartan44 49 28 1111.7CD36, NPPA, NPPB, MMP1, NR3C2, AGTR1
45creatinine448.6PPARA, NPPA, NPPB, TIMP2, CD36, AOC3
46potassium44 11 2410.6ACE, AGT, AGTR1, NR3C2, CYP11B2, NPPA
47cholesterol44 28 11 2411.5ACE, CYP11B2, AGT, AGTR1, NR3C2, AOC3
48nitric oxide44 11 2410.5CYP11B2, AGT, AGTR1, NR3C2, TIMP2, AOC3
49h2o2448.3AGTR1, AOC3, AGT, ANXA5, MMP1, CD36
50calcium44 49 11 2410.1MMP1, ANXA5, CD36, ACE, ADCY10, AGTR1

GO Terms for genes affiliated with Hypertensive Heart Disease

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16Gene Ontology
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Cellular components related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1ACE, AGT, CTF1, NPPA, NPPB, TIMP2
2extracellular regionGO:0055768.2ACE, TIMP2, NPPB, NPPA, CTF1, AGT

Biological processes related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3ACE, AGTR1
2cGMP biosynthetic processGO:00618210.3NPR1, NPPB, NPPA
3regulation of vascular permeabilityGO:04311410.3NPPB, NPR1
4positive regulation of NAD(P)H oxidase activityGO:03386410.3AGTR1, AGT
5receptor guanylyl cyclase signaling pathwayGO:00716810.3NPPA, NPPB, NPR1
6regulation of blood vessel sizeGO:05088010.3NPR1, NPPB, NPPA
7regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
8body fluid secretionGO:00758910.3NPPB, NPR1
9regulation of renal sodium excretionGO:03581310.2AGTR1, AGT
10regulation of renal output by angiotensinGO:00201910.2AGT, ACE
11renin-angiotensin regulation of aldosterone productionGO:00201810.2AGTR1, AGT
12positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
13positive regulation of renal sodium excretionGO:03581510.2NPR1, NPPB, AGT
14positive regulation of urine volumeGO:03581010.1NPPB, NPR1
15positive regulation of macrophage derived foam cell differentiationGO:01074410.1CD36, AGT, AGTR1
16regulation of vasodilationGO:04231210.1ACE, AGTR1, NPPB, NPR1
17positive regulation of reactive oxygen species metabolic processGO:200037910.1CD36, AGT, AGTR1
18regulation of vasoconstrictionGO:01922910.1AGTR1, AGT, ACE
19low-density lipoprotein particle remodelingGO:03437410.0AGTR1, AGT
20negative regulation of cell growthGO:0303089.9NPR1, NPPB, NPPA, AGT
21positive regulation of MAPK cascadeGO:0434109.9CD36, AGT, TIMP2
22regulation of blood pressureGO:0082179.8CACNA1B, NPR1, NPPB, NPPA, ACE
23angiotensin maturationGO:0020039.8ACE, AGT
24kidney developmentGO:0018229.8ACE, AGT, AGTR1
25positive regulation of cellular protein metabolic processGO:0322709.7AGT, AGTR1

Molecular functions related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.9AGT, AGTR1
2bradykinin receptor bindingGO:0317119.8ACE, AGTR1
3hormone activityGO:0051799.8AGT, NPPA, NPPB

Products for genes affiliated with Hypertensive Heart Disease

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Sources for Hypertensive Heart Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet