MCID: HYP006
MIFTS: 49

Hypertensive Heart Disease malady

Cardiovascular diseases category

Summaries for Hypertensive Heart Disease

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Wikipedia:65 Hypertensive heart disease includes a number of complications of high blood pressure that affect the... more...

MalaCards based summary: Hypertensive Heart Disease is related to atrial fibrillation and coronary artery disease. An important gene associated with Hypertensive Heart Disease is NPR1 (natriuretic peptide receptor 1), and among its related pathways are PPAR signaling pathway and Adipocytokine signaling pathway. The compounds urodilatin and gw9662 have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and endothelial, and related mouse phenotypes are immune system and muscle.

Disease Ontology:10 A heart disease that is caused by high blood presure.

Aliases & Classifications for Hypertensive Heart Disease

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 29ICD9CM, 57SNOMED-CT, 27ICD10
See all sources

Hypertensive Heart Disease, Aliases & Descriptions:

Name: Hypertensive Heart Disease 10 12 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:11516
ICD9CM29 402.9, 402
ICD1027 I11, I11.0, I11.9

Related Diseases for Hypertensive Heart Disease

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Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1atrial fibrillation30.5NPPB, AGTR1
2coronary artery disease30.5NPPB, AGTR1
3vascular disease30.2AGTR1, PPARA
4cor pulmonale30.0NPPB, AGTR1
5myocardial infarction30.0NPPB, AGTR1, NPR1
6hypertrophic cardiomyopathy10.6
7ischemia10.4
8artery disease10.3
9pulmonary hypertension10.3
10diastolic heart failure10.3
11dilated cardiomyopathy10.2
12nephrosclerosis10.2
13amyloidosis10.2
14left ventricular outflow tract obstruction10.2
15endotheliitis10.2
16fabry disease10.0
17obesity10.0
18cerebral hemorrhage10.0
19arteriolosclerosis10.0
20rheumatic heart disease10.0
21dextrocardia10.0
22erythromelalgia10.0
23alcoholic cardiomyopathy10.0
24gastric ulcer10.0
25miliary tuberculosis10.0
26situs inversus10.0
27polycystic kidney disease10.0
28cerebritis10.0
29angioedema10.0
30dermatitis10.0
31kidney disease10.0
32myocarditis10.0
33pyelonephritis10.0
34tuberculosis10.0
35congenital varicella syndrome10.0
36dextrocardia with situs inversus10.0
37renal dysplasia10.0
38familial hyperlipidemia10.0AGTR1, PPARA
39idiopathic edema10.0NPPB, PPARA
40hypercholesterolemia, familial10.0PPARA, AGTR1
41osteoporosis10.0CD36
42hyperinsulinism10.0PPARA, AGTR1
43acute myocardial infarction10.0AGTR1, NPPB
44renal fibrosis10.0CD36, AGTR1
45glomerulosclerosis10.0CD36, AGTR1
46pulmonary fibrosis10.0CD36, AGTR1
47noonan syndrome 110.0AGTR1, NPPB
48congestive heart failure10.0NPR1, AGTR1, NPPB
49hypertension, essential10.0NPPB, AGTR1, NPR1
50stroke, ischemic10.0NPR1, NPPB, AGTR1

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to hypertensive heart disease

Symptoms for Hypertensive Heart Disease

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Drugs & Therapeutics for Hypertensive Heart Disease

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Drug clinical trials:

Search ClinicalTrials for Hypertensive Heart Disease

Search NIH Clinical Center for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

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Anatomical Context for Hypertensive Heart Disease

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MalaCards organs/tissues related to Hypertensive Heart Disease:

33
Heart, Monocytes, Endothelial, Bone marrow, Bone, Kidney, Testes, Tongue

Animal Models for Hypertensive Heart Disease or affiliated genes

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MGI Mouse Phenotypes related to Hypertensive Heart Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2AGTR1, CD36, NPR1, PPARA
2MP:00053697.8PPARA, NPPB, NPR1, CD36
3MP:00053857.4AGTR1, CD36, NPR1, NPPB, PPARA

Publications for Hypertensive Heart Disease

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Articles related to Hypertensive Heart Disease:

(show top 50)    (show all 328)
idTitleAuthorsYear
1
Hypertensive heart disease and obesity: a complex interaction between hemodynamic and not hemodynamic factors. (24821373)
2014
2
Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. (24140724)
2013
3
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease. (23657971)
2013
4
Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities. (22886534)
2013
5
Gene expression profiles of peripheral blood mononuclear cells reveal transcriptional signatures as novel biomarkers of cardiac remodeling in rats with aldosteronism and hypertensive heart disease. (24622010)
2013
6
MRI differentiation of cardiomyopathy showing left ventricular hypertrophy and heart failure: differentiation between cardiac amyloidosis, hypertrophic cardiomyopathy, and hypertensive heart disease. (23996116)
2013
7
Elevated circulating fibrocyte levels in patients with hypertensive heart disease. (22796709)
2012
8
Hypertensive heart disease: bone marrow as a significant player in pathologic remodelling? (22895017)
2012
9
Should African-Americans with elevated blood pressure be routinely screened for hypertensive heart disease? (23190057)
2012
10
Cardiotrophin-1 in hypertensive heart disease. (22418690)
2012
11
Dominance of hypertensive heart disease in a tertiary hospital in southern Nigeria: an echocardiographic study. (22764633)
2012
12
Preface: hypertension and hypertensive heart disease. (20937439)
2010
13
Is Smad3 the key to inflammation and fibrosis in hypertensive heart disease? (20231519)
2010
14
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. (19117407)
2009
15
Influence of the type and degree of left ventricular hypertrophy on the prevalence of ventricular arrhythmias in patients with hypertensive heart disease. (18936895)
2008
16
Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction. (17766279)
2007
17
31P-MR spectroscopic imaging in hypertensive heart disease. (16514468)
2006
18
Are myocardial fibrosis and diastolic dysfunction reversible in hypertensive heart disease? (16330908)
2005
19
New directions in the assessment and treatment of hypertensive heart disease. (16046900)
2005
20
Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists. (15372301)
2004
21
Monocyte chemoattractant protein-1: a key mediator of angiotensin II-induced target organ damage in hypertensive heart disease? (15076146)
2004
22
Clinical implications of apoptosis in hypertensive heart disease. (12679323)
2003
23
Candesartan cilexetil improves left ventricular function, left ventricular hypertrophy, and endothelial function in patients with hypertensive heart disease. (12419928)
2002
24
Cardioreparation in hypertensive heart disease. (11566936)
2001
25
Behavioral treatment of hypertensive heart disease in African Americans: rationale and design of a randomized controlled trial. (11763829)
2001
26
Cardiac involvement in autosomal-dominant polycystic kidney disease: a hypertensive heart disease. (11597036)
2001
27
Ischemia and fibrosis: the risk mechanisms of hypertensive heart disease. (10829097)
2000
28
Regression of myocardial fibrosis in hypertensive heart disease: diverse effects of various antihypertensive drugs. (10773237)
2000
29
Indicators and treatment of hypertensive heart disease. (10901763)
1999
30
Hypertensive heart disease. (10652906)
1999
31
Hypertensive heart disease, ventricular dysrhythmias, and sudden death. (9433533)
1997
32
Modulation of hypertensive heart disease by estrogen. (8733001)
1996
33
Diabetic and hypertensive heart disease. (8678395)
1996
34
Coronary microcirculation in hypertensive heart disease: functional significance and therapeutic implications. (8518540)
1993
35
Coronary haemodynamics in hypertensive heart disease. (1396859)
1992
36
Development of cardiac failure by coronary small vessel disease in hypertensive heart disease? (1838764)
1991
37
Coronary vascular changes in the progression and regression of hypertensive heart disease. (1720480)
1991
38
Predicting hypertensive heart disease via non-invasive methodology: relationship between ambulatory blood pressure and cardiac indices derived by echocardiography and radionuclide ventriculography. (2150531)
1990
39
Hypertensive heart disease: relationship of silent ischemia to coronary artery disease and left ventricular hypertrophy. (2145735)
1990
40
Comparative analysis of cardiac function, geometry, energetics and coronary reserve in hypertensive heart disease. (2962004)
1987
41
Usefulness of stress testing for the evaluation of hypertensive heart disease in young hypertensive subjects. (6488227)
1984
42
The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload. (6217955)
1983
43
Ischemic and hypertensive heart disease in the aged: prognostic and therapeutic factors. (7410762)
1980
44
Diastolic time intervals in ischemic and hypertensive heart disease: A comparison of isovolumic relaxation time and rapid filling time with systolic time intervals. (1149531)
1975
45
Clinical-physiological correlations in the development of hypertensive heart disease. (4255490)
1971
46
Prognosis of hypertensive heart disease. (13339176)
1956
47
Hypertensive heart disease, a confusing term; pathogenic considerations. (13274389)
1955
48
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
49
Recent trends in hypertensive heart disease. (15399041)
1950
50
Hypertensive heart disease; case report. (21004782)
1945

Variations for Hypertensive Heart Disease

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Expression for genes affiliated with Hypertensive Heart Disease

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Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for genes affiliated with Hypertensive Heart Disease

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Pathways related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
fatty acid beta-oxidation VI (peroxisome)38
9.1CD36, PPARA
29.1CD36, PPARA

Compounds for genes affiliated with Hypertensive Heart Disease

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Compounds related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1urodilatin459.8NPR1, NPPB
2gw966245 3010.8AGTR1, PPARA
38-bromo cgmp459.7NPPB, NPR1
4trandolapril45 1310.7NPPB, AGTR1
5fosinopril45 1310.7NPPB, AGTR1
6lisinopril45 51 26 1312.7NPPB, AGTR1
7ramipril45 1310.7AGTR1, NPPB
8aldosterone30 26 1311.7AGTR1, NPPB
9valsartan45 61 30 1312.7AGTR1, NPPB
10perindopril45 51 1311.6AGTR1, NPPB
11atenolol45 51 30 26 1313.6NPPB, AGTR1
12amiodarone45 51 30 1312.6PPARA, NPPB
13candesartan45 51 30 1312.6NPPB, AGTR1
14enalapril45 51 1311.6AGTR1, NPPB
15amlodipine45 51 26 1312.6AGTR1, NPPB
16spironolactone45 61 30 51 1313.5AGTR1, NPPB
17pd12331945 3010.5CD36, AGTR1
18carvedilol45 51 30 1312.5NPPB, AGTR1
198-isoprostane459.4NPPB, AGTR1
20p005459.3NPPB, AGTR1
21nitroglycerin45 1310.3AGTR1, NPR1, NPPB
22sodium nitroprusside459.3NPPB, NPR1, AGTR1
23guanylate459.3AGTR1, NPR1, NPPB
24cgmp45 3010.3AGTR1, NPR1, NPPB
25telmisartan45 30 1311.3PPARA, NPPB, AGTR1
26digoxin45 61 51 26 1313.2NPPB, AGTR1
27pravastatin45 51 30 26 1313.2AGTR1, NPPB, PPARA
28prostacyclin459.2AGTR1, NPPB, PPARA
29aspirin45 51 30 2612.2AGTR1, NPPB, PPARA
30norepinephrine45 26 1311.1AGTR1, NPPB, PPARA
31actinomycin d459.1AGTR1, NPPB, PPARA
32furosemide45 61 30 51 26 1314.0AGTR1, NPPB
33forskolin45 51 1311.0AGTR1, NPR1, NPPB
34ang ii458.9NPPB, CD36, AGTR1
35captopril45 61 51 30 1312.9NPPB, CD36, AGTR1
36pioglitazone30 45 51 1311.9PPARA, NPPB, CD36
37losartan45 51 30 1311.9AGTR1, CD36, NPPB
38sodium45 269.9AGTR1, NPR1, NPPB
39sb 20358045 619.8AGTR1, CD36, NPPB
40pge2458.6CD36, NPPB, PPARA
41rosiglitazone30 45 51 26 1312.4PPARA, NPPB, CD36, AGTR1
42tacrolimus45 51 1310.4AGTR1, CD36, NPPB, PPARA
43cysteine458.4AGTR1, CD36, NPR1, NPPB
44genistein45 30 61 3 26 1313.4AGTR1, CD36, NPPB, PPARA
45creatinine458.4PPARA, NPPB, CD36, AGTR1
46dexamethasone45 51 30 1311.4PPARA, NPPB, CD36, AGTR1
47vegf458.4PPARA, NPPB, CD36, AGTR1
48vitamin d458.0AGTR1, CD36, NPR1, NPPB, PPARA
49estrogen458.0PPARA, NPPB, NPR1, CD36, AGTR1
50serine458.0PPARA, NPPB, NPR1, CD36, AGTR1

GO Terms for genes affiliated with Hypertensive Heart Disease

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Cellular components related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.7AGTR1, CD36, NPR1

Biological processes related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of vascular permeabilityGO:00431149.7NPR1, NPPB
2cGMP biosynthetic processGO:00061829.7NPR1, NPPB
3body fluid secretionGO:00075899.7NPR1, NPPB
4receptor guanylyl cyclase signaling pathwayGO:00071689.6NPPB, NPR1
5positive regulation of urine volumeGO:00358109.6NPPB, NPR1
6positive regulation of renal sodium excretionGO:00358159.6NPR1, NPPB
7regulation of blood vessel sizeGO:00508809.6NPR1, NPPB
8negative regulation of angiogenesisGO:00165259.5NPPB, NPR1
9regulation of blood pressureGO:00082179.4NPPB, NPR1
10positive regulation of macrophage derived foam cell differentiationGO:00107449.3CD36, AGTR1
11positive regulation of reactive oxygen species metabolic processGO:020003799.2AGTR1, CD36
12regulation of vasodilationGO:00423129.2NPPB, NPR1, AGTR1
13cellular lipid metabolic processGO:00442559.1PPARA, CD36
14negative regulation of cell growthGO:00303089.1NPPB, NPR1
15lipid metabolic processGO:00066299.0CD36, PPARA
16cell surface receptor signaling pathwayGO:00071668.8NPPB, NPR1, CD36

Molecular functions related to Hypertensive Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:00082899.1CD36, PPARA

Products for genes affiliated with Hypertensive Heart Disease

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Sources for Hypertensive Heart Disease

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet