MCID: HYP008
MIFTS: 38

Hypertensive Retinopathy malady

Summaries for Hypertensive Retinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

MalaCards: Hypertensive Retinopathy is related to hypertension and diabetic retinopathy. An important gene associated with Hypertensive Retinopathy is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are Selected targets of C/EBPalpha and Binding and Uptake of Ligands by Scavenger Receptors. The compounds losartan and aopp have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and heart, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Hypertensive Retinopathy

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

hypertensive retinopathy 8 10 60


External Ids:

Disease Ontology8 DOID:11561
MeSH34 D058437
ICD9CM27 362.11
NCIt39 C3514

Related Diseases for Hypertensive Retinopathy

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17GeneCards, 18GeneDecks
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Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.5ALB, ACE
2diabetic retinopathy30.3ACE, ALB
3vascular disease29.9FTH1
4atherosclerosis29.9ADIPOQ, ALB, ACE
5essential hypertension29.9ALB, ADIPOQ, ACE
6malignant hypertension10.4
7retinitis10.3
8pheochromocytoma10.3
9renovascular hypertension10.2
10neuroretinitis10.1
11eclampsia10.1
12hypertensive heart disease10.1
13renal hypertension10.1
14fatty liver disease10.0FTH1
15glucose intolerance10.0ADIPOQ
16acromegaly10.0ADIPOQ
17hemochromatosis10.0FTH1
18hypertriglyceridemia10.0ADIPOQ
19hypogonadism10.0ADIPOQ
20metabolic syndrome x10.0ADIPOQ
21arteriosclerosis obliterans10.0ADIPOQ
22prion disease10.0FTH1
23coronary stenosis10.0ADIPOQ
24porphyria cutanea tarda10.0FTH1
25coronary artery disease10.0
26choroiditis10.0
27sensorineural hearing loss10.0
28systemic lupus erythematosus10.0
29brachydactyly10.0
30macular holes10.0
31aortic atherosclerosis10.0
32lupus erythematosus10.0
33neuropathy10.0
34pre-eclampsia10.0
35retinal detachment10.0
36retinal disease10.0
37retinal vascular disease10.0
38scleroderma10.0
39glomerulonephritis10.0ALB
40hepatorenal syndrome10.0ALB
41cholestasis10.0ALB
42rhinitis10.0ALB
43peripheral vascular disease10.0ALB
44pancreatitis10.0ALB
45anuria10.0ACE
46ovarian hyperstimulation syndrome10.0ALB
47pulmonary embolism10.0ALB
48hypokalemia10.0ACE
49acute myocardial infarction10.0ACE
50dilated cardiomyopathy10.0ACE

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to hypertensive retinopathy

Clinical Features for Hypertensive Retinopathy

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Drugs & Therapeutics for Hypertensive Retinopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypertensive Retinopathy

Drug clinical trials:

Search ClinicalTrials for Hypertensive Retinopathy

Search NIH Clinical Center for Hypertensive Retinopathy

Search CenterWatch for Hypertensive Retinopathy

Genetic Tests for Hypertensive Retinopathy

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Anatomical Context for Hypertensive Retinopathy

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32MalaCards
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MalaCards organs/tissues related to Hypertensive Retinopathy:

32
Retina, Eye, Heart, Breast, Monocytes

Animal Models for Hypertensive Retinopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertensive Retinopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ADIPOQ, ALB, ACE, FTH1

Publications for Hypertensive Retinopathy

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50PubMed
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Articles related to Hypertensive Retinopathy:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
A woman with didanosine retinopathy and non-cirrhotic portal hypertension. (24400350)
2013
2
Hypertensive retinopathy: comparing the Keith-Wagener-Barker to a simplified classification. (23449021)
2013
3
Hypertensive retinopathy: incidence, risk factors, and comorbidities. (22468968)
2012
4
Hypertensive retinopathy in a child caused by pheochromocytoma: identification after a failed school vision screening. (22245022)
2012
5
Microalbuminuria and hypertensive retinopathy among newly diagnosed nondiabetic hypertensive adult Nigerians. (22248945)
2011
6
Relationship between left ventricular hypertrophy, hypertensive retinopathy, microalbuminuria and echocardiographic modalities in newly diagnosed hypertensive patients. (20111906)
2010
7
Masked hypertension, nocturnal blood pressure and retinopathy in normotensive patients with type 1 diabetes. (19926157)
2010
8
Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy. (19829016)
2010
9
Blood pressure development and hypertensive retinopathy: 20-year follow-up of middle-aged normotensive and hypertensive men. (20010619)
2010
10
A case of systemic lupus erythematosus presenting as malignant hypertension with hypertensive retinopathy. (20830234)
2010
11
Relationship of early hypertensive retinopathy to inflammation markers and microalbuminuria in hypertensive patients with regulated blood pressure. (17334487)
2007
12
Bilateral foveal neurosensory detachment in hypertensive retinopathy demonstrated by optical coherence tomography. (16575418)
2006
13
Progressive venous stasis retinopathy and open-angle glaucoma associated with primary pulmonary hypertension. (16749260)
2006
14
The relationship between hypertensive retinopathy and Angiotensin converting enzyme gene polymorphism. (16724936)
2006
15
Copper and silver wiring in hypertensive retinopathy. (16612263)
2006
16
Malignant hypertensive retinopathy studied with optical coherence tomography. (15805924)
2005
17
Hypertensive retinopathy. (15564546)
2004
18
Blood pressure assessment in healthy cats and cats with hypertensive retinopathy. (14974583)
2004
19
Serum level of low-density lipoprotein cholesterol in hypertensive retinopathy. (12971535)
2003
20
Racial differences in the prevalence of hypertensive retinopathy. (12654714)
2003
21
Hypertensive retinopathy in a cat. (12650046)
2003
22
Treatment of hypertensive retinopathy. (12431701)
2002
23
Reversible hypertensive retinopathy in a child with bilateral pheochromocytoma after tumor resection. (11155750)
2000
24
Absence of hypertensive retinopathy in a Turkish kindred with autosomal dominant hypertension and brachydactyly. (9930264)
1998
25
Hypertensive retinopathy mimicking neuroretinitis in a twelve-year-old girl. (9220570)
1997
26
Hypertensive retinopathy simulating Leber idiopathic stellate neuroretinitis. (9400800)
1997
27
Hypertensive retinopathy: a review of existing classification systems and a suggestion for a simplified grading system. (8867562)
1996
28
Idiopathic polypoidal choroidal vasculopathy associated with retinal arterial macroaneurysm and hypertensive retinopathy. (8724952)
1996
29
Hypertensive retinopathy in Afro-Caribbeans and Europeans. Prevalence and risk factor relationships. (7768581)
1995
30
Endothelium and diabetes: study of plasma levels of endothelin-1 in diabetic patients with arterial hypertension or proliferative retinopathy]. (7603606)
1995
31
High prevalence of hypertensive retinopathy and coronary heart disease in hypertensive patients with persistent microalbuminuria under short intensive antihypertensive therapy. (8026113)
1994
32
Resolution of hypertensive retinopathy despite persistent high diastolic pressure. (8434291)
1993
33
Hypertensive retinopathy: a cause of decreased visual acuity in children. (1432515)
1992
34
Cicletanine and hypertensive retinopathy. (2090985)
1990
35
Calcium metabolic indices, vascular retinopathy, and plasma renin activity in essential hypertension. (2081011)
1990
36
Hypertensive retinopathy. (2748095)
1989
37
Severe hypertensive retinopathy. Increased incidence in renoparenchymal hypertension. (3434598)
1987
38
Hypertensive retinopathy in the newborn infant. (6631611)
1983
39
Hypertensive retinopathy. Description, classification, and prognosis. (7155523)
1982
40
Hypertensive retinopathy in Nigerians. A prospective clinical study of 350 cases. (7342375)
1981
41
Paediatrics: hypertensive retinopathy. (6899149)
1980
42
Pathogenesis of hypertensive retinopathy: a review. (399635)
1979
43
Hypertensive retinopathy: a suggested modified classification. (455422)
1979
44
Retinal ischemia (capillary nonperfusion) in diabetic retinopathy of patients with and without systemic hypertension. (745825)
1978
45
Reversible hypertensive retinopathy. (301240)
1977
46
Pathogenesis of hypertensive retinopathy. An experimental study in the monkey. (804913)
1975
47
Hypertensive retinopathy. A prospective hospital study of 100 hypertensive Kenyan Africans. (4845025)
1974
48
THE PATHOLOGY OF HYPERTENSIVE RETINOPATHY. (14123188)
1963
49
The star-figure of the macular area; histopathological study of a case of angiospastic (hypertensive) retinopathy. (13544665)
1958
50
Diabetic and hypertensive retinopathy. (14888036)
1951

Genetic Variations for Hypertensive Retinopathy

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Expression for genes affiliated with Hypertensive Retinopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for genes affiliated with Hypertensive Retinopathy

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12EMD Millipore, 53Reactome
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Pathways related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ADIPOQ, ALB
29.4ALB, FTH1

Compounds for genes affiliated with Hypertensive Retinopathy

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1losartan44 49 28 1113.4ALB
2aopp4410.0ADIPOQ, ALB
3gliclazide44 49 1111.9ADIPOQ, ALB
4olmesartan44 28 1111.9ACE, ADIPOQ
5metoprolol44 28 49 11 2413.9ADIPOQ, ACE
6saquinavir44 1110.9ALB, ADIPOQ
7indapamide44 1110.9ALB, ACE
8rosuvastatin44 49 28 1112.9ADIPOQ, ALB
9fosinopril44 1110.8ACE, ALB
1025-hydroxyvitamin d449.8ADIPOQ, ALB
11lisinopril44 11 2411.8ALB, ACE
12perindopril44 49 1111.8ACE, ALB
13hydrochlorothiazide44 49 28 11 2413.8ALB, ACE
14spironolactone49 44 59 28 1113.8ALB, ACE
15furosemide44 49 59 28 11 2414.7ALB, ACE
16olanzapine49 44 28 11 2413.7ADIPOQ, ALB
17captopril44 28 49 59 1113.7ACE, ALB
18halothane44 28 1111.5FTH1, ALB
19warfarin44 49 11 2412.5ACE, ALB
20ramipril44 1110.5ADIPOQ, ALB, ACE
21valsartan44 59 28 1112.5ACE, ALB, ADIPOQ
22telmisartan44 28 1111.5ADIPOQ, ALB, ACE
23irbesartan44 28 49 1112.5ACE, ALB, ADIPOQ
24candesartan44 28 1111.5ADIPOQ, ALB, ACE
25enalapril44 49 1111.5ADIPOQ, ALB, ACE
26amlodipine44 49 11 2412.5ACE, ALB, ADIPOQ
27kininogen449.4ALB, ACE
28ascorbic acid44 2410.3ADIPOQ, ALB, FTH1
29metformin44 49 1111.2ADIPOQ, ACE
30creatinine449.1ADIPOQ, ALB, ACE
31lipid448.6ADIPOQ, ALB, ACE, FTH1

GO Terms for genes affiliated with Hypertensive Retinopathy

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16Gene Ontology
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Biological processes related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.6ADIPOQ, ALB

Molecular functions related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.5ALB, ACE

Products for genes affiliated with Hypertensive Retinopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertensive Retinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet