MCID: HYP008
MIFTS: 38

Hypertensive Retinopathy

Categories: Eye diseases

Aliases & Classifications for Hypertensive Retinopathy

MalaCards integrated aliases for Hypertensive Retinopathy:

Name: Hypertensive Retinopathy 12 29 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11561
ICD10 33 H35.03
ICD9CM 35 362.11
MeSH 42 D058437
NCIt 47 C3514
UMLS 69 C0152132

Summaries for Hypertensive Retinopathy

MalaCards based summary : Hypertensive Retinopathy is related to idiopathic juxtafoveal retinal telangiectasia and hypothyroidism due to iodide transport defect. An important gene associated with Hypertensive Retinopathy is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Angiogenesis (CST) and Renin secretion. The drugs Angiotensin-Converting Enzyme Inhibitors and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include retina, brain and eye, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

Related Diseases for Hypertensive Retinopathy

Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 idiopathic juxtafoveal retinal telangiectasia 10.4 ACE ADIPOQ
2 hypothyroidism due to iodide transport defect 10.4 ACE REN
3 primary hyperoxaluria 10.4 ACE REN
4 atrial septal defect 7, with or without av conduction defects 10.4 ACE REN
5 mody, type ii 10.4 ACE REN
6 hypodontia of incisors and premolars 10.4 ACE REN
7 non-congenital cyst of kidney 10.4 ACE REN
8 clitoris cancer 10.4 ACE REN
9 cataract, autosomal dominant congenital 4 10.3 ACE VWF
10 chronic diarrhea due to guanylate cyclase 2c overactivity 10.3 ACE VWF
11 voyeurism 10.3 ACE REN
12 adenocarcinoma 10.3 ACE REN
13 chylocele of tunica vaginalis 10.3 ACE REN
14 myopia 10.3 ACE REN
15 fibular aplasia ectrodactyly 10.3 ACE REN
16 broad ligament malignant neoplasm 10.3 ACE REN
17 vaginal endometrial stromal sarcoma 10.3 ADIPOQ REN
18 lymphadenitis 10.3 ACE REN
19 cascade stomach 10.3 ACE REN
20 pyogenic arthritis, pyoderma gangrenosum and acne 10.3 ACE REN
21 renal tubular dysgenesis 10.3 ACE REN
22 pulmonary valve insufficiency 10.3 ACE REN
23 microphthalmia, isolated, with coloboma 7 10.3 ACE REN
24 ischemic heart disease 10.3 ACE VWF
25 cystinosis 10.2 ACE REN
26 congenital bilateral megacalycosis 10.2 ACE REN
27 skin squamous cell carcinoma 10.2 ACE ADIPOQ
28 renal fibrosis 10.2 ACE VWF
29 pediatric angiosarcoma 10.2 ACE REN
30 renal clear cell carcinoma 10.2 ACE REN
31 pyelonephritis 10.2 ACE REN
32 prostate neuroendocrine neoplasm 10.2 ACE REN
33 calcinosis 10.1 ACE REN
34 angina pectoris 10.1 ACE VWF
35 lacrimal system cancer 10.1 ACE VWF
36 malignant hypertension 10.0
37 adult respiratory distress syndrome 10.0 ACE VWF
38 retinitis 10.0
39 craniosynostosis 9.9 ACE REN
40 chronic myelomonocytic leukemia 9.9 ACE REN
41 pheochromocytoma 9.9
42 diabetic encephalopathy 9.9 ACE ADIPOQ REN
43 periampullary adenoma 9.9 ACE ADIPOQ REN
44 macular degeneration, age-related, 12 9.9 ACE ADIPOQ VWF
45 adams-oliver syndrome 5 9.9 ACE REN VWF
46 craniosynostosis 7 9.9 ACE REN VWF
47 malignant type ab thymoma 9.8 ACE REN VWF
48 cervix uteri carcinoma in situ 9.8 ACE REN
49 stroke, ischemic 9.8 ACE REN VWF
50 lubani-al saleh-teebi syndrome 9.8 ACE REN VWF

Comorbidity relations with Hypertensive Retinopathy via Phenotypic Disease Network (PDN):


Deficiency Anemia Hypertension, Essential
Malignant Essential Hypertension

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to Hypertensive Retinopathy

Symptoms & Phenotypes for Hypertensive Retinopathy

MGI Mouse Phenotypes related to Hypertensive Retinopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 ACE ADIPOQ FTH1 REN VWF
2 hematopoietic system MP:0005397 9.35 ACE ADIPOQ FTH1 REN VWF
3 immune system MP:0005387 9.02 REN VWF ACE ADIPOQ FTH1

Drugs & Therapeutics for Hypertensive Retinopathy

Drugs for Hypertensive Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Angiotensin-Converting Enzyme Inhibitors Phase 1
2 Antihypertensive Agents Phase 1
3 calcium channel blockers Phase 1
4 Calcium, Dietary Phase 1
5
Carbon monoxide Approved 630-08-0 281
6
Menthol Approved 2216-51-5 16666
7
Glucosamine Approved, Nutraceutical 3416-24-8 439213
8 Anticoagulants
9 Antimetabolites
10 Fibrinolytic Agents
11 Glucuronyl glucosamine glycan sulfate
12 Hypoglycemic Agents
13 Hypolipidemic Agents
14 Lipid Regulating Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Research Study in Patients With Persistent Macular Edema Completed NCT00035906 Phase 2 DEX PS DDS®
2 Effect of High Blood Pressure and Antihypertensive Treatment on Brain Functioning in Children Completed NCT00178490 Phase 1 High blood pressure treatment
3 Establishment of a Perinatal Database and a Bank of Biological Materials Completed NCT00339235
4 Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy Recruiting NCT01753648
5 Morbidity in Patients With Hypertension and Obstructive Sleep Apnea Recruiting NCT02270658
6 Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation Recruiting NCT01820117
7 DETECT and Retinal Outcomes in Hypertension Recruiting NCT01815567
8 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Hypertensive Retinopathy

Cochrane evidence based reviews: hypertensive retinopathy

Genetic Tests for Hypertensive Retinopathy

Genetic tests related to Hypertensive Retinopathy:

id Genetic test Affiliating Genes
1 Hypertensive Retinopathy 29

Anatomical Context for Hypertensive Retinopathy

MalaCards organs/tissues related to Hypertensive Retinopathy:

39
Retina, Brain, Eye, Heart, Liver, Kidney, Endothelial

Publications for Hypertensive Retinopathy

Articles related to Hypertensive Retinopathy:

(show top 50) (show all 153)
id Title Authors Year
1
Assessment of left atrium and diastolic dysfunction in patients with hypertensive retinopathy: A real-time three-dimensional echocardiography-based study. ( 28758803 )
2017
2
Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults. ( 28577362 )
2017
3
Malignant Hypertensive Retinopathy in an Infant with Mid-Aortic Occlusion. ( 27795862 )
2016
4
Proliferative Hypertensive Retinopathy. ( 26767543 )
2016
5
Hypertensive retinopathy in a transgenic angiotensin-based model. ( 27026533 )
2016
6
Multimodal Imaging of Elschnig Spots: A Case of Simultaneous Hypertensive Retinopathy, Choroidopathy, and Neuropathy. ( 27082847 )
2016
7
Hypertensive retinopathy and cerebral small vessel disease in Amerindians living in rural Ecuador: The Atahualpa Project. ( 27232913 )
2016
8
Consideration of hypertensive retinopathy as an important end-organ damage in patients with hypertension. ( 27465980 )
2016
9
Review of hypertensive retinopathy. ( 27931746 )
2016
10
P1113Relationship between left atrium and hypertensive retinopathy in patients with systemic hypertension: a real-time three-dimensional echocardiography-based study. ( 28415121 )
2016
11
The Keith-Wagener-Barker and Mitchell-Wong grading systems for hypertensive retinopathy: association with target organ damage in individuals below 55 years. ( 26335430 )
2015
12
Hypertensive Retinopathy as the First Manifestation of Advanced Renal Disease in a Young Patient: Report of a Case. ( 26955342 )
2015
13
Malignant hypertensive retinopathy as a presenting sign of an occult dead fetus. ( 26082609 )
2015
14
Relationship of Hypertensive Retinopathy with Mean Platelet Volume Among Hypertensive Patients. ( 26835193 )
2015
15
Updated classification of hypertensive retinopathy: which role for cardiovascular risk stratification? ( 26425835 )
2015
16
Hypertensive Retinopathy, Choroidopathy, and Optic Neuropathy. ( 26448430 )
2015
17
Tremendous result of bevacizumab in malignant hypertensive retinopathy. ( 25709280 )
2015
18
7D.08: DETECTING HYPERTENSIVE RETINOPATHY USING RETINAL VASCULAR GEOMETRY. ( 26102655 )
2015
19
Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL. ( 26167496 )
2015
20
Bilateral hypertensive retinopathy diagnostic of pheochromocytoma. ( 25443213 )
2015
21
Hypertensive retinopathy revealing a pheochromocytoma associated with a liver hydatid cyst in a child. ( 25955378 )
2015
22
Diabetes retinopathy is a poor predictor for renal and cardiovascular outcomes in comparison with hypertensive retinopathy in patients with chronic kidney disease. ( 26008724 )
2015
23
Images in clinical medicine. Hypertensive retinopathy associated with preeclampsia. ( 24552322 )
2014
24
Detection of hypertensive retinopathy using vessel measurements and textural features. ( 25571216 )
2014
25
The association between endothelial dysfunction and hypertensive retinopathy in essential hypertension. ( 24441931 )
2014
26
Bilateral Hypertensive Retinopathy Complicated with Retinal Neovascularization: Panretinal Photocoagulation or Intravitreal Anti-VEGF Treatment? ( 25232335 )
2014
27
Hypertensive retinopathy and its association with cardiovascular, renal and cerebrovascular morbidity in Congolese patients. ( 25629539 )
2014
28
Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. ( 23148140 )
2013
29
Hypertensive retinopathy and risk of stroke. ( 23940194 )
2013
30
Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. ( 23521027 )
2013
31
Hypertensive retinopathy: comparing the Keith-Wagener-Barker to a simplified classification. ( 23449021 )
2013
32
The association of oxidative stress with hypertensive retinopathy. ( 22571627 )
2013
33
Hypertensive retinopathy: incidence, risk factors, and comorbidities. ( 22468968 )
2012
34
Effect of intravitreal bevacizumab (Avastin(Ar)) therapy in malignant hypertensive retinopathy: a report of two cases. ( 22149905 )
2012
35
Hypertensive retinopathy in a child caused by pheochromocytoma: identification after a failed school vision screening. ( 22245022 )
2012
36
Grade III or Grade IV Hypertensive Retinopathy with Severely Elevated Blood Pressure. ( 23359839 )
2012
37
Restoration of outer segments of foveal photoreceptors after resolution of malignant hypertensive retinopathy. ( 23275917 )
2012
38
Hypertensive retinopathy and visual outcome in hypertensive disorders in pregnancy. ( 23765142 )
2011
39
Microalbuminuria and hypertensive retinopathy among newly diagnosed nondiabetic hypertensive adult Nigerians. ( 22248945 )
2011
40
Relationship of hypertensive retinopathy to thoracic aortic atherosclerosis in patients with severe arterial hypertension. ( 21214413 )
2011
41
Hypertensive retinopathy in a child. ( 20693485 )
2011
42
Relationship between left ventricular hypertrophy, hypertensive retinopathy, microalbuminuria and echocardiographic modalities in newly diagnosed hypertensive patients. ( 20111906 )
2010
43
Direct ophthalmoscopy versus detection of hypertensive retinopathy: a comparative study. ( 20602008 )
2010
44
A case of systemic lupus erythematosus presenting as malignant hypertension with hypertensive retinopathy. ( 20830234 )
2010
45
The association of low-grade systemic inflammation with hypertensive retinopathy. ( 21091359 )
2010
46
Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy. ( 19829016 )
2010
47
Relation between grade II hypertensive retinopathy and coronary artery disease in treated essential hypertensives. ( 21029012 )
2010
48
Serum ferritin levels correlate with hypertensive retinopathy. ( 20110920 )
2010
49
Blood pressure development and hypertensive retinopathy: 20-year follow-up of middle-aged normotensive and hypertensive men. ( 20010619 )
2010
50
Support system for the preventive diagnosis of hypertensive retinopathy. ( 21097309 )
2010

Variations for Hypertensive Retinopathy

Expression for Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for Hypertensive Retinopathy

Pathways related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.9 REN VWF
2 10.44 ACE REN

GO Terms for Hypertensive Retinopathy

Cellular components related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ACE ADIPOQ FTH1 REN VWF

Biological processes related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.32 ACE REN
2 regulation of blood pressure GO:0008217 9.26 ACE REN
3 cellular response to drug GO:0035690 9.16 ADIPOQ REN
4 beta-amyloid metabolic process GO:0050435 8.96 ACE REN
5 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Hypertensive Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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