MCID: HYP008
MIFTS: 43

Hypertensive Retinopathy malady

Eye diseases category
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Summaries for Hypertensive Retinopathy

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

MalaCards: Hypertensive Retinopathy is related to hypertension and vascular disease. An important gene associated with Hypertensive Retinopathy is FTH1 (ferritin, heavy polypeptide 1), and among its related pathways are Glucose / Energy Metabolism and Binding and Uptake of Ligands by Scavenger Receptors. The compounds olmesartan and metoprolol have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and heart, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Hypertensive Retinopathy

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

hypertensive retinopathy 8 10 62


External Ids:

Disease Ontology8 DOID:11561
NCIt40 C3514
MeSH35 D058437
ICD9CM27 362.11

Related Diseases for Hypertensive Retinopathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.6ACE, ALB
2vascular disease30.0ADIPOQ, ACE
3essential hypertension29.9ACE, ADIPOQ, ALB
4atherosclerosis29.9ACE, ADIPOQ, ALB
5coronary artery disease29.9ADIPOQ, ACE
6malignant hypertension10.4
7retinitis10.4
8pheochromocytoma10.3
9renovascular hypertension10.3
10neuroretinitis10.2
11eclampsia10.2
12hepatorenal syndrome10.1ALB
13anuria10.1ACE
14galactosemia10.0ADIPOQ, ALB
15uremia10.0ALB, ADIPOQ
16renal artery disease10.0ALB, ACE
17macular holes10.0
18aortic atherosclerosis10.0
19choroiditis10.0
20sensorineural hearing loss10.0
21systemic lupus erythematosus10.0
22brachydactyly10.0
23artery disease10.0
24lupus erythematosus10.0
25neuropathy10.0
26pre-eclampsia10.0
27retinal detachment10.0
28retinal vascular disease10.0
29hypertensive nephropathy10.0ALB, ACE
30peripheral vascular disease10.0ALB, ACE
31focal segmental glomerulosclerosis10.0ACE, ALB
32hepatitis c10.0FTH1, ALB
33cork-handlers' disease10.0ACE, ALB
34glomerulosclerosis10.0ACE, ALB
35diabetic retinopathy10.0ACE, ALB
36iga glomerulonephritis10.0ACE, ALB
37stroke, ischemic10.0ACE, ALB
38nephritis10.0ACE, ALB
39idiopathic edema10.0ADIPOQ, ACE
40nephrotic syndrome10.0ACE, ALB
41type 1 diabetes mellitus10.0ACE, ALB
42liver cirrhosis10.0ALB, ADIPOQ
43familial hyperlipidemia10.0ACE, ADIPOQ
44hypercholesterolemia10.0ADIPOQ, ACE
45primary hyperoxaluria10.0ALB, ACE
46congenital heart disease10.0ACE, ADIPOQ
47arthritis10.0ADIPOQ, FTH1, ALB
48hepatitis b10.0ALB, ADIPOQ
49deficiency anemia10.0ALB, FTH1, ACE
50diabetic nephropathy9.9ADIPOQ, ACE, ALB

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to hypertensive retinopathy

Symptoms for Hypertensive Retinopathy

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Drugs & Therapeutics for Hypertensive Retinopathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Hypertensive Retinopathy

Search NIH Clinical Center for Hypertensive Retinopathy

Genetic Tests for Hypertensive Retinopathy

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Anatomical Context for Hypertensive Retinopathy

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33MalaCards
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MalaCards organs/tissues related to Hypertensive Retinopathy:

33
Retina, Eye, Heart, Breast

Animal Models for Hypertensive Retinopathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypertensive Retinopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5ALB, ACE, ADIPOQ
2MP:00053678.2ALB, ACE, ADIPOQ
3MP:00053708.1ALB, ACE, FTH1, ADIPOQ
4MP:00053768.1ALB, ACE, FTH1, ADIPOQ
5MP:00053848.0ADIPOQ, FTH1, ACE, ALB

Publications for Hypertensive Retinopathy

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Sources:
52PubMed
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Articles related to Hypertensive Retinopathy:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Hypertensive retinopathy and risk of stroke. (23940194)
2013
2
Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. (23148140)
2013
3
Hypertensive retinopathy: incidence, risk factors, and comorbidities. (22468968)
2012
4
Hypertensive retinopathy in a child caused by pheochromocytoma: identification after a failed school vision screening. (22245022)
2012
5
Microalbuminuria and hypertensive retinopathy among newly diagnosed nondiabetic hypertensive adult Nigerians. (22248945)
2011
6
Support system for the preventive diagnosis of hypertensive retinopathy. (21097309)
2010
7
Serum ferritin levels correlate with hypertensive retinopathy. (20110920)
2010
8
Relationship between left ventricular hypertrophy, hypertensive retinopathy, microalbuminuria and echocardiographic modalities in newly diagnosed hypertensive patients. (20111906)
2010
9
Prevalence and severity of hypertensive retinopathy in children. (19571332)
2009
10
Hypertensive retinopathy and sensorineural hearing loss. (23120650)
2009
11
Severe bilateral hypertensive retinopathy and optic neuropathy in a patient with pheochromocytoma. (18454411)
2008
12
Hypertensive retinopathy: a window to vascular remodeling in arterial hypertension. (17998472)
2008
13
The relationship between the breast arterial calcification detected by mammography and the hypertensive retinopathy in hypertensive women. (18682669)
2008
14
Hypertensive retinopathy and risk of cardiovascular diseases in a national cohort. (22518227)
2008
15
Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy. (17186260)
2007
16
Relationship of early hypertensive retinopathy to inflammation markers and microalbuminuria in hypertensive patients with regulated blood pressure. (17334487)
2007
17
Bilateral foveal neurosensory detachment in hypertensive retinopathy demonstrated by optical coherence tomography. (16575418)
2006
18
Fred Hollows lecture: hypertensive retinopathy - a journey from fundoscopy to digital imaging. (16872333)
2006
19
Hypertensive retinopathy revisited: some answers, more questions. (16299149)
2005
20
Hypertensive retinopathy. (15564546)
2004
21
Serum level of low-density lipoprotein cholesterol in hypertensive retinopathy. (12971535)
2003
22
Racial differences in the prevalence of hypertensive retinopathy. (12654714)
2003
23
Malignant hypertensive retinopathy-clinical and fundus manifestations in patients with new onset or acute exacerbation of chronic hypertension. (14651165)
2003
24
Bilateral renal artery stenosis presenting as hypertensive retinopathy and choroidopathy. (12355701)
2002
25
Hypertensive retinopathy and incident coronary heart disease in high risk men. (12185127)
2002
26
Is leptin associated with hypertensive retinopathy? (10690876)
2000
27
Reversible hypertensive retinopathy in a child with bilateral pheochromocytoma after tumor resection. (11155750)
2000
28
Dramatic regression of hypertensive retinopathy following renal transplantation: a case report. (9595099)
1998
29
Hypertensive retinopathy mimicking neuroretinitis in a twelve-year-old girl. (9220570)
1997
30
Hypertensive retinopathy simulating Leber idiopathic stellate neuroretinitis. (9400800)
1997
31
Hypertensive retinopathy: a cause of decreased visual acuity in children. (1432515)
1992
32
Hypertensive retinopathy caused by a rare ovarian tumor: case report and photo essay. (1814990)
1991
33
Cicletanine and hypertensive retinopathy. (2090985)
1990
34
Hypertensive retinopathy. (6544301)
1983
35
Hypertensive retinopathy in renovascular hypertension. (7360168)
1980
36
Pathogenesis of hypertensive retinopathy: a review. (399635)
1979
37
The regression of hypertensive retinopathy. (649917)
1978
38
Reversible hypertensive retinopathy. (301240)
1977
39
Pathogenesis of hypertensive retinopathy. An experimental study in the monkey. (804913)
1975
40
Editorial: Hypertensive retinopathy. (807893)
1975
41
Role of local factors in hypertensive retinopathy. (4461687)
1974
42
Experimental hypertensive retinopathy: ultrastructure. (4998607)
1971
43
The rarity of hypertensive retinopathy in the African. (5672739)
1968
44
CHOKED DISC OR HYPERTENSIVE RETINOPATHY IV? (14213922)
1964
45
THE PATHOLOGY OF COTTON WOOL SPOTS AND CYTOID BODIES IN HYPERTENSIVE RETINOPATHY AND OTHER DISEASES. (14123190)
1963
46
The star-figure of the macular area; histopathological study of a case of angiospastic (hypertensive) retinopathy. (13544665)
1958
47
The treatment of hypertensive retinopathy. (13339163)
1956
48
Hypertensive retinopathy and its medical treatment. (13215778)
1954
49
Diabetic and hypertensive retinopathy. (14888036)
1951
50
Hypertensive retinopathy in a girl aged 10 years 11 months. (21001842)
1946

Variations for Hypertensive Retinopathy

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Expression for genes affiliated with Hypertensive Retinopathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for genes affiliated with Hypertensive Retinopathy

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Sources:
50PathCards, 5Cell Signaling Technology, 55Reactome, 12EMD Millipore
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Compounds for genes affiliated with Hypertensive Retinopathy

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1olmesartan45 29 1111.8ADIPOQ, ACE
2metoprolol45 51 29 24 1113.8ACE, ADIPOQ
3metformin45 51 1111.7ACE, ADIPOQ
4pravastatin45 51 29 24 1113.6ACE, ADIPOQ
5atorvastatin45 51 29 24 1113.6ACE, ADIPOQ
6aopp459.6ALB, ADIPOQ
7halothane45 51 29 1112.6FTH1, ALB
8gliclazide45 51 1111.5ADIPOQ, ALB
9nifedipine45 29 51 1112.5ACE, ADIPOQ
10saquinavir45 1110.5ADIPOQ, ALB
11rosuvastatin45 51 29 1112.5ALB, ADIPOQ
1225-hydroxyvitamin d459.5ALB, ADIPOQ
13olanzapine45 51 29 24 1113.5ADIPOQ, ALB
14indapamide45 1110.5ACE, ALB
15fosinopril45 1110.5ACE, ALB
16uric acid45 2410.5ALB, ADIPOQ
17mannitol45 1110.5ALB, FTH1
18lisinopril45 51 24 1112.5ALB, ACE
19zidovudine45 51 1111.4ADIPOQ, ALB
20perindopril45 51 1111.4ALB, ACE
21hydrochlorothiazide45 29 51 24 1113.4ALB, ACE
22spironolactone45 61 29 51 1113.4ALB, ACE
23estrone45 29 24 1112.4ALB, ADIPOQ
24palmitate459.4ADIPOQ, ALB
25furosemide45 61 29 51 24 1114.4ACE, ALB
26homocysteine45 2410.4ALB, ADIPOQ
27captopril45 61 51 29 1113.4ALB, ACE
28warfarin45 51 24 1112.4ALB, ACE
29kininogen459.4ALB, ACE
30rosiglitazone29 45 51 24 1113.4ADIPOQ, ALB
31prostacyclin459.3ADIPOQ, ACE
32aspirin45 51 29 2412.3ACE, ADIPOQ
33citrate459.3ALB, ADIPOQ
34thyroxine45 2410.2ALB, ADIPOQ
35folate459.2ALB, ADIPOQ
36ascorbic acid45 2410.1ALB, FTH1, ADIPOQ
37tacrolimus45 51 1111.0ALB, ADIPOQ
38ramipril45 1110.0ALB, ACE, ADIPOQ
39valsartan45 61 29 1112.0ADIPOQ, ACE, ALB
40telmisartan45 29 1111.0ALB, ACE, ADIPOQ
41irbesartan45 29 51 1112.0ADIPOQ, ACE, ALB
42candesartan45 51 29 1112.0ALB, ACE, ADIPOQ
43amlodipine45 51 24 1112.0ADIPOQ, ACE, ALB
44enalapril45 51 1110.9ADIPOQ, ACE, ALB
45losartan45 51 29 1111.9ALB, ACE, ADIPOQ
46creatinine458.9ALB, ACE, ADIPOQ
47cholesterol45 29 24 1111.8ALB, ACE, ADIPOQ
48vitamin a45 24 1110.8ALB, ADIPOQ
49glucose458.7ADIPOQ, ACE, ALB
50lipid458.5ADIPOQ, FTH1, ACE, ALB

GO Terms for genes affiliated with Hypertensive Retinopathy

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16Gene Ontology
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Cellular components related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5ALB, ACE, ADIPOQ

Biological processes related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.1ALB, ADIPOQ

Molecular functions related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081448.7ALB, ACE
2protein bindingGO:0055157.5ALB, ACE, FTH1, PSMD9, ADIPOQ

Products for genes affiliated with Hypertensive Retinopathy

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Sources for Hypertensive Retinopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet