MCID: HYP008
MIFTS: 38

Hypertensive Retinopathy malady

Summaries for Hypertensive Retinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

MalaCards: Hypertensive Retinopathy is related to hypertension and diabetic retinopathy. An important gene associated with Hypertensive Retinopathy is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are Selected targets of C/EBPalpha and Binding and Uptake of Ligands by Scavenger Receptors. The compounds losartan and aopp have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and heart, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Hypertensive Retinopathy

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

hypertensive retinopathy 8 10 60


External Ids:

Disease Ontology8 DOID:11561
MeSH34 D058437
ICD9CM27 362.11
NCIt39 C3514

Related Diseases for Hypertensive Retinopathy

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17GeneCards, 18GeneDecks
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Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.5ALB, ACE
2diabetic retinopathy30.3ACE, ALB
3vascular disease29.9FTH1
4atherosclerosis29.9ADIPOQ, ALB, ACE
5essential hypertension29.9ALB, ADIPOQ, ACE
6malignant hypertension10.4
7retinitis10.3
8pheochromocytoma10.3
9renovascular hypertension10.2
10neuroretinitis10.1
11eclampsia10.1
12hypertensive heart disease10.1
13renal hypertension10.1
14fatty liver disease10.0FTH1
15glucose intolerance10.0ADIPOQ
16acromegaly10.0ADIPOQ
17hemochromatosis10.0FTH1
18hypertriglyceridemia10.0ADIPOQ
19hypogonadism10.0ADIPOQ
20metabolic syndrome x10.0ADIPOQ
21arteriosclerosis obliterans10.0ADIPOQ
22prion disease10.0FTH1
23coronary stenosis10.0ADIPOQ
24porphyria cutanea tarda10.0FTH1
25coronary artery disease10.0
26choroiditis10.0
27sensorineural hearing loss10.0
28systemic lupus erythematosus10.0
29brachydactyly10.0
30macular holes10.0
31aortic atherosclerosis10.0
32lupus erythematosus10.0
33neuropathy10.0
34pre-eclampsia10.0
35retinal detachment10.0
36retinal disease10.0
37retinal vascular disease10.0
38scleroderma10.0
39glomerulonephritis10.0ALB
40hepatorenal syndrome10.0ALB
41cholestasis10.0ALB
42rhinitis10.0ALB
43peripheral vascular disease10.0ALB
44pancreatitis10.0ALB
45anuria10.0ACE
46ovarian hyperstimulation syndrome10.0ALB
47pulmonary embolism10.0ALB
48hypokalemia10.0ACE
49acute myocardial infarction10.0ACE
50dilated cardiomyopathy10.0ACE

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to hypertensive retinopathy

Clinical Features for Hypertensive Retinopathy

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Drugs & Therapeutics for Hypertensive Retinopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypertensive Retinopathy

Drug clinical trials:

Search ClinicalTrials for Hypertensive Retinopathy

Search NIH Clinical Center for Hypertensive Retinopathy

Search CenterWatch for Hypertensive Retinopathy

Genetic Tests for Hypertensive Retinopathy

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Anatomical Context for Hypertensive Retinopathy

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32MalaCards
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MalaCards organs/tissues related to Hypertensive Retinopathy:

32
Retina, Eye, Heart, Breast, Monocytes

Animal Models for Hypertensive Retinopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertensive Retinopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ADIPOQ, ALB, ACE, FTH1

Publications for Hypertensive Retinopathy

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50PubMed
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Articles related to Hypertensive Retinopathy:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Longitudinal Prevalence of Hypertension, Proteinuria, and Retinopathy in Dogs with Spontaneous Diabetes Mellitus. (24417733)
2014
2
Intravitreal bevacizumab in persistent retinopathy secondary to malignant hypertension. (23964183)
2013
3
Hypertensive retinopathy and risk of stroke. (23940194)
2013
4
Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. (23148140)
2013
5
Effect of intravitreal bevacizumab (Avastin(Ar)) therapy in malignant hypertensive retinopathy: a report of two cases. (22149905)
2012
6
Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy. (21610567)
2011
7
Relationship of hypertensive retinopathy to thoracic aortic atherosclerosis in patients with severe arterial hypertension. (21214413)
2011
8
Support system for the preventive diagnosis of hypertensive retinopathy. (21097309)
2010
9
The association of low-grade systemic inflammation with hypertensive retinopathy. (21091359)
2010
10
Hypertensive retinopathy and sensorineural hearing loss. (23120650)
2009
11
Severe bilateral hypertensive retinopathy and optic neuropathy in a patient with pheochromocytoma. (18454411)
2008
12
Hypertensive retinopathy: a window to vascular remodeling in arterial hypertension. (17998472)
2008
13
The relationship between the breast arterial calcification detected by mammography and the hypertensive retinopathy in hypertensive women. (18682669)
2008
14
Hypertensive retinopathy and risk of cardiovascular diseases in a national cohort. (22518227)
2008
15
The association of mean platelet volume levels with hypertensive retinopathy. (17852776)
2008
16
Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy. (17186260)
2007
17
Fred Hollows lecture: hypertensive retinopathy - a journey from fundoscopy to digital imaging. (16872333)
2006
18
Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. (17406200)
2006
19
Hypertensive retinopathy revisited: some answers, more questions. (16299149)
2005
20
Images in clinical medicine. Improvement in hypertensive retinopathy after treatment of hypertension. (15872195)
2005
21
The association of plasma adiponectin levels with hypertensive retinopathy. (15745931)
2005
22
Hypertensive retinopathy signs as risk indicators of cardiovascular morbidity and mortality. (16148191)
2005
23
Hypertensive retinopathy: there's more than meets the eye. (15775767)
2005
24
Hypertensive retinopathy and choroidopathy in a cat. (14738501)
2004
25
Malignant hypertensive retinopathy-clinical and fundus manifestations in patients with new onset or acute exacerbation of chronic hypertension. (14651165)
2003
26
Hypertensive retinopathy and incident coronary heart disease in high risk men. (12185127)
2002
27
The Eye as a Target Organ: An Updated Classification of Hypertensive Retinopathy. (11416646)
2000
28
Dramatic regression of hypertensive retinopathy following renal transplantation: a case report. (9595099)
1998
29
Macular hole following severe hypertensive retinopathy. (8031264)
1994
30
Pathophysiology of hypertensive retinopathy. (7155524)
1982
31
Hypertensive retinopathy in renovascular hypertension. (7360168)
1980
32
Hypertensive retinopathy in renovascular hypertension. (7360169)
1980
33
Bilateral exudative retinal detachment in eclampsia without hypertensive retinopathy. (7446666)
1980
34
Ophthalmoscopy. Hypertensive retinopathy. (476343)
1979
35
Editorial: Hypertensive retinopathy. (807893)
1975
36
Serum lipids in hypertensive retinopathy. (1236319)
1975
37
Editorial: Pathogenesis of hypertensive retinopathy. (804951)
1975
38
Role of local factors in hypertensive retinopathy. (4461687)
1974
39
The rarity of hypertensive retinopathy in the African. (5347214)
1969
40
Experimental hypertensive retinopathy in the monkey. (4989799)
1969
41
The rarity of hypertensive retinopathy in the African. (5672739)
1968
42
Hypertensive retinopathy. Caliber changes in retinal blood vessels following blood-pressure reduction and inhalation of oxygen. (5649083)
1968
43
Early hypertensive retinopathy. (20791046)
1966
44
CHOKED DISC OR HYPERTENSIVE RETINOPATHY IV? (14213922)
1964
45
Ophthalmoscopic evaluation of hypertensive retinopathy. (13980430)
1963
46
HYPERTENSIVE RETINOPATHY STUDIED WITH FLUORESCEIN. (14123138)
1963
47
HYPERTENSIVE RETINOPATHY. (14123170)
1963
48
Hypertensive retinopathy from the clinical viewpoint. (14006929)
1961
49
The treatment of hypertensive retinopathy. (13339163)
1956
50
Hypertensive retinopathy associated with adrenal medullary tumor (pheochromocytoma). (21012367)
1945

Genetic Variations for Hypertensive Retinopathy

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Expression for genes affiliated with Hypertensive Retinopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for genes affiliated with Hypertensive Retinopathy

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12EMD Millipore, 53Reactome
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Pathways related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ADIPOQ, ALB
29.4ALB, FTH1

Compounds for genes affiliated with Hypertensive Retinopathy

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1losartan44 49 28 1113.4ALB
2aopp4410.0ADIPOQ, ALB
3gliclazide44 49 1111.9ADIPOQ, ALB
4olmesartan44 28 1111.9ACE, ADIPOQ
5metoprolol44 28 49 11 2413.9ACE, ADIPOQ
6saquinavir44 1110.9ALB, ADIPOQ
7indapamide44 1110.9ACE, ALB
8rosuvastatin44 49 28 1112.9ADIPOQ, ALB
9fosinopril44 1110.8ACE, ALB
1025-hydroxyvitamin d449.8ALB, ADIPOQ
11lisinopril44 11 2411.8ACE, ALB
12perindopril44 49 1111.8ACE, ALB
13hydrochlorothiazide44 49 28 11 2413.8ALB, ACE
14spironolactone49 44 59 28 1113.8ACE, ALB
15furosemide44 49 59 28 11 2414.7ALB, ACE
16olanzapine49 44 28 11 2413.7ALB, ADIPOQ
17captopril44 28 49 59 1113.7ALB, ACE
18halothane44 28 1111.5ALB, FTH1
19warfarin44 49 11 2412.5ACE, ALB
20ramipril44 1110.5ADIPOQ, ALB, ACE
21valsartan44 59 28 1112.5ADIPOQ, ACE, ALB
22telmisartan44 28 1111.5ACE, ALB, ADIPOQ
23irbesartan44 28 49 1112.5ADIPOQ, ALB, ACE
24candesartan44 28 1111.5ACE, ALB, ADIPOQ
25enalapril44 49 1111.5ALB, ADIPOQ, ACE
26amlodipine44 49 11 2412.5ACE, ADIPOQ, ALB
27kininogen449.4ALB, ACE
28ascorbic acid44 2410.3FTH1, ALB, ADIPOQ
29metformin44 49 1111.2ACE, ADIPOQ
30creatinine449.1ADIPOQ, ACE, ALB
31lipid448.6FTH1, ALB, ACE, ADIPOQ

GO Terms for genes affiliated with Hypertensive Retinopathy

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16Gene Ontology
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Biological processes related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.6ADIPOQ, ALB

Molecular functions related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.5ALB, ACE

Products for genes affiliated with Hypertensive Retinopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertensive Retinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet