MCID: HYP008
MIFTS: 35

Hypertensive Retinopathy malady

Summaries for Hypertensive Retinopathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

MalaCards: Hypertensive Retinopathy is related to coronary heart disease and vascular disease. An important gene associated with Hypertensive Retinopathy is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are Selected targets of C/EBPalpha and Binding and Uptake of Ligands by Scavenger Receptors. The compounds losartan and aopp have been mentioned in the context of this disorder. Affiliated tissues include retina, heart and breast, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Hypertensive Retinopathy

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

hypertensive retinopathy 8 10 61


External Ids:

Disease Ontology8 DOID:11561
MeSH35 D058437
ICD9CM27 362.11
NCIt40 C3514

Related Diseases for Hypertensive Retinopathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1coronary heart disease30.2ADIPOQ, ACE
2vascular disease30.0FTH1
3atherosclerosis29.9ACE, ALB, ADIPOQ
4pheochromocytoma10.3
5renovascular hypertension10.2
6neuroretinitis10.1
7eclampsia10.1
8hypertensive heart disease10.1
9coronary artery disease,10.0
10sensorineural hearing loss10.0
11systemic lupus erythematosus10.0
12brachydactyly10.0
13aortic atherosclerosis10.0
14fatty liver disease10.0FTH1
15glucose intolerance10.0ADIPOQ
16acromegaly10.0ADIPOQ
17hemochromatosis10.0FTH1
18hypertriglyceridemia10.0ADIPOQ
19hypogonadism10.0ADIPOQ
20metabolic syndrome x10.0ADIPOQ
21arteriosclerosis obliterans10.0ADIPOQ
22prion disease10.0FTH1
23coronary stenosis10.0ADIPOQ
24porphyria cutanea tarda10.0FTH1
25glomerulonephritis10.0ALB
26hepatorenal syndrome10.0ALB
27cholestasis10.0ALB
28rhinitis10.0ALB
29peripheral vascular disease10.0ALB
30pancreatitis10.0ALB
31anuria10.0ACE
32ovarian hyperstimulation syndrome10.0ALB
33pulmonary embolism10.0ALB
34hypokalemia10.0ACE
35acute myocardial infarction10.0ACE
36dilated cardiomyopathy10.0ACE
37tuberculosis10.0ALB
38uremia10.0ADIPOQ, ALB
39liver cirrhosis10.0ADIPOQ, ALB
40hepatitis c10.0ALB, FTH1
41galactosemia10.0ALB, ADIPOQ
42hypercholesterolemia10.0ADIPOQ, ACE
43idiopathic edema10.0ACE, ADIPOQ
44hypertension10.0ALB, ACE
45diabetic retinopathy10.0ALB, ACE
46hypertensive nephropathy10.0ACE, ALB
47nephrotic syndrome10.0ALB, ACE
48renal vascular disease10.0ALB, ACE
49cork-handlers' disease10.0ALB, ACE
50focal segmental glomerulosclerosis10.0ALB, ACE

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to hypertensive retinopathy

Clinical Features for Hypertensive Retinopathy

Drugs & Therapeutics for Hypertensive Retinopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypertensive Retinopathy

Drug clinical trials:

Search ClinicalTrials for Hypertensive Retinopathy

Search NIH Clinical Center for Hypertensive Retinopathy

Search CenterWatch for Hypertensive Retinopathy

Genetic Tests for Hypertensive Retinopathy

Anatomical Context for Hypertensive Retinopathy

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypertensive Retinopathy:

33
Retina, Heart, Breast

Animal Models for Hypertensive Retinopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hypertensive Retinopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ADIPOQ, ALB, ACE, FTH1

Publications for Hypertensive Retinopathy

Sources:
51PubMed
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Articles related to Hypertensive Retinopathy:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Hypertensive retinopathy and risk of stroke. (23940194)
2013
2
Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. (23148140)
2013
3
The association of oxidative stress with hypertensive retinopathy. (22571627)
2013
4
Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. (23521027)
2013
5
Hypertensive retinopathy: comparing the Keith-Wagener-Barker to a simplified classification. (23449021)
2013
6
Grade III or Grade IV Hypertensive Retinopathy with Severely Elevated Blood Pressure. (23359839)
2012
7
Restoration of outer segments of foveal photoreceptors after resolution of malignant hypertensive retinopathy. (23275917)
2012
8
Hypertensive retinopathy in a child. (20693485)
2011
9
Support system for the preventive diagnosis of hypertensive retinopathy. (21097309)
2010
10
Blood pressure development and hypertensive retinopathy: 20-year follow-up of middle-aged normotensive and hypertensive men. (20010619)
2010
11
A case of systemic lupus erythematosus presenting as malignant hypertension with hypertensive retinopathy. (20830234)
2010
12
The association of low-grade systemic inflammation with hypertensive retinopathy. (21091359)
2010
13
Prevalence and severity of hypertensive retinopathy in children. (19571332)
2009
14
Hypertensive retinopathy and sensorineural hearing loss. (23120650)
2009
15
Severe bilateral hypertensive retinopathy and optic neuropathy in a patient with pheochromocytoma. (18454411)
2008
16
Hypertensive retinopathy: a window to vascular remodeling in arterial hypertension. (17998472)
2008
17
Hypertensive retinopathy and risk of cardiovascular diseases in a national cohort. (22518227)
2008
18
Malignant hypertension, severe hypertensive retinopathy and malignant nephroangiosclerosis. (18551923)
2008
19
Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy. (17186260)
2007
20
Fred Hollows lecture: hypertensive retinopathy - a journey from fundoscopy to digital imaging. (16872333)
2006
21
Hypertensive retinopathy revisited: some answers, more questions. (16299149)
2005
22
Images in clinical medicine. Improvement in hypertensive retinopathy after treatment of hypertension. (15872195)
2005
23
Malignant hypertensive retinopathy studied with optical coherence tomography. (15805924)
2005
24
Hypertensive retinopathy and choroidopathy in a cat. (14738501)
2004
25
Serum level of low-density lipoprotein cholesterol in hypertensive retinopathy. (12971535)
2003
26
Hypertensive retinopathy in a cat. (12650046)
2003
27
Hypertensive retinopathy and incident coronary heart disease in high risk men. (12185127)
2002
28
Treatment of hypertensive retinopathy. (12431701)
2002
29
Dramatic regression of hypertensive retinopathy following renal transplantation: a case report. (9595099)
1998
30
Diagnostic ophthalmology. Hypertensive retinopathy. (9262864)
1997
31
Idiopathic polypoidal choroidal vasculopathy associated with retinal arterial macroaneurysm and hypertensive retinopathy. (8724952)
1996
32
High prevalence of hypertensive retinopathy and coronary heart disease in hypertensive patients with persistent microalbuminuria under short intensive antihypertensive therapy. (8026113)
1994
33
Resolution of hypertensive retinopathy despite persistent high diastolic pressure. (8434291)
1993
34
Hypertensive retinopathy caused by a rare ovarian tumor: case report and photo essay. (1814990)
1991
35
Hypertensive retinopathy. (2748095)
1989
36
Hypertensive retinopathy in the newborn infant. (6631611)
1983
37
Hypertensive retinopathy. Description, classification, and prognosis. (7155523)
1982
38
Hypertensive retinopathy in renovascular hypertension. (7360168)
1980
39
Paediatrics: hypertensive retinopathy. (6899149)
1980
40
Hypertensive retinopathy: a suggested modified classification. (455422)
1979
41
Editorial: Hypertensive retinopathy. (807893)
1975
42
Serum lipids in hypertensive retinopathy. (1236319)
1975
43
Role of local factors in hypertensive retinopathy. (4461687)
1974
44
Experimental hypertensive retinopathy: circulatory changes. (4998606)
1971
45
The rarity of hypertensive retinopathy in the African. (5672739)
1968
46
CHOKED DISC OR HYPERTENSIVE RETINOPATHY IV? (14213922)
1964
47
THE PATHOLOGY OF COTTON WOOL SPOTS AND CYTOID BODIES IN HYPERTENSIVE RETINOPATHY AND OTHER DISEASES. (14123190)
1963
48
THE PATHOLOGY OF HYPERTENSIVE RETINOPATHY. (14123188)
1963
49
Improvement in hypertensive retinopathy following adrenal resection and sympathectomy; results in one hundred eleven patients. (13457521)
1957
50
The treatment of hypertensive retinopathy. (13339163)
1956

Genetic Variations for Hypertensive Retinopathy

Expression for genes affiliated with Hypertensive Retinopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for genes affiliated with Hypertensive Retinopathy

Sources:
12EMD Millipore, 54Reactome
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Pathways related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ADIPOQ, ALB
29.4ALB, FTH1

Compounds for genes affiliated with Hypertensive Retinopathy

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1losartan45 50 29 1113.4ALB
2aopp4510.0ADIPOQ, ALB
3gliclazide45 50 1111.9ADIPOQ, ALB
4olmesartan45 29 1111.9ACE, ADIPOQ
5metoprolol45 29 50 11 2413.9ADIPOQ, ACE
6saquinavir45 1110.9ALB, ADIPOQ
7indapamide45 1110.9ALB, ACE
8rosuvastatin45 50 29 1112.9ADIPOQ, ALB
9fosinopril45 1110.8ACE, ALB
1025-hydroxyvitamin d459.8ADIPOQ, ALB
11lisinopril45 11 2411.8ALB, ACE
12perindopril45 50 1111.8ACE, ALB
13hydrochlorothiazide45 50 29 11 2413.8ALB, ACE
14spironolactone50 45 60 29 1113.8ALB, ACE
15furosemide45 50 60 29 11 2414.7ALB, ACE
16olanzapine50 45 29 11 2413.7ADIPOQ, ALB
17captopril45 29 50 60 1113.7ACE, ALB
18halothane45 29 1111.5FTH1, ALB
19warfarin45 50 11 2412.5ACE, ALB
20ramipril45 1110.5ADIPOQ, ALB, ACE
21valsartan45 60 29 1112.5ACE, ALB, ADIPOQ
22telmisartan45 29 1111.5ADIPOQ, ALB, ACE
23irbesartan45 29 50 1112.5ACE, ALB, ADIPOQ
24candesartan45 29 1111.5ADIPOQ, ALB, ACE
25enalapril45 50 1111.5ADIPOQ, ALB, ACE
26amlodipine45 50 11 2412.5ACE, ALB, ADIPOQ
27kininogen459.4ALB, ACE
28ascorbic acid45 2410.3ADIPOQ, ALB, FTH1
29metformin45 50 1111.2ADIPOQ, ACE
30creatinine459.1ADIPOQ, ALB, ACE
31lipid458.6ADIPOQ, ALB, ACE, FTH1

GO Terms for genes affiliated with Hypertensive Retinopathy

Sources:
16Gene Ontology
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Biological processes related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.6ADIPOQ, ALB

Molecular functions related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.5ALB, ACE

Products for genes affiliated with Hypertensive Retinopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertensive Retinopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet