MCID: HYP008
MIFTS: 38

Hypertensive Retinopathy malady

Summaries for Hypertensive Retinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

MalaCards: Hypertensive Retinopathy is related to hypertension and diabetic retinopathy. An important gene associated with Hypertensive Retinopathy is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are Selected targets of C/EBPalpha and Binding and Uptake of Ligands by Scavenger Receptors. The compounds losartan and aopp have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and heart, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Hypertensive Retinopathy

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

hypertensive retinopathy 8 10 60


External Ids:

Disease Ontology8 DOID:11561
MeSH34 D058437
ICD9CM27 362.11
NCIt39 C3514

Related Diseases for Hypertensive Retinopathy

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17GeneCards, 18GeneDecks
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Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.5ALB, ACE
2diabetic retinopathy30.3ACE, ALB
3vascular disease29.9FTH1
4atherosclerosis29.9ADIPOQ, ALB, ACE
5essential hypertension29.9ALB, ADIPOQ, ACE
6malignant hypertension10.4
7retinitis10.3
8pheochromocytoma10.3
9renovascular hypertension10.2
10neuroretinitis10.1
11eclampsia10.1
12hypertensive heart disease10.1
13renal hypertension10.1
14fatty liver disease10.0FTH1
15glucose intolerance10.0ADIPOQ
16acromegaly10.0ADIPOQ
17hemochromatosis10.0FTH1
18hypertriglyceridemia10.0ADIPOQ
19hypogonadism10.0ADIPOQ
20metabolic syndrome x10.0ADIPOQ
21arteriosclerosis obliterans10.0ADIPOQ
22prion disease10.0FTH1
23coronary stenosis10.0ADIPOQ
24porphyria cutanea tarda10.0FTH1
25coronary artery disease10.0
26choroiditis10.0
27sensorineural hearing loss10.0
28systemic lupus erythematosus10.0
29brachydactyly10.0
30macular holes10.0
31aortic atherosclerosis10.0
32lupus erythematosus10.0
33neuropathy10.0
34pre-eclampsia10.0
35retinal detachment10.0
36retinal disease10.0
37retinal vascular disease10.0
38scleroderma10.0
39glomerulonephritis10.0ALB
40hepatorenal syndrome10.0ALB
41cholestasis10.0ALB
42rhinitis10.0ALB
43peripheral vascular disease10.0ALB
44pancreatitis10.0ALB
45anuria10.0ACE
46ovarian hyperstimulation syndrome10.0ALB
47pulmonary embolism10.0ALB
48hypokalemia10.0ACE
49acute myocardial infarction10.0ACE
50dilated cardiomyopathy10.0ACE

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to hypertensive retinopathy

Clinical Features for Hypertensive Retinopathy

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Drugs & Therapeutics for Hypertensive Retinopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypertensive Retinopathy

Drug clinical trials:

Search ClinicalTrials for Hypertensive Retinopathy

Search NIH Clinical Center for Hypertensive Retinopathy

Search CenterWatch for Hypertensive Retinopathy

Genetic Tests for Hypertensive Retinopathy

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Anatomical Context for Hypertensive Retinopathy

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32MalaCards
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MalaCards organs/tissues related to Hypertensive Retinopathy:

32
Retina, Eye, Heart, Breast, Monocytes

Animal Models for Hypertensive Retinopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertensive Retinopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ADIPOQ, ALB, ACE, FTH1

Publications for Hypertensive Retinopathy

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50PubMed
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Articles related to Hypertensive Retinopathy:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
A woman with didanosine retinopathy and non-cirrhotic portal hypertension. (24400350)
2013
2
Pre-eclampsia and pregnancy-induced hypertension are associated with severe diabetic retinopathy in type 1 diabetes later in life. (22955518)
2013
3
The association of oxidative stress with hypertensive retinopathy. (22571627)
2013
4
Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. (23521027)
2013
5
Hypertensive retinopathy: comparing the Keith-Wagener-Barker to a simplified classification. (23449021)
2013
6
Hypertensive retinopathy: incidence, risk factors, and comorbidities. (22468968)
2012
7
Hypertensive retinopathy in a child caused by pheochromocytoma: identification after a failed school vision screening. (22245022)
2012
8
Grade III or Grade IV Hypertensive Retinopathy with Severely Elevated Blood Pressure. (23359839)
2012
9
Microalbuminuria and hypertensive retinopathy among newly diagnosed nondiabetic hypertensive adult Nigerians. (22248945)
2011
10
Hypertensive retinopathy in a child. (20693485)
2011
11
Decompression Retinopathy after ExPRESS Shunt Implantation for Steroid-Induced Ocular Hypertension: A Case Report. (22611508)
2011
12
Serum ferritin levels correlate with hypertensive retinopathy. (20110920)
2010
13
Blood pressure development and hypertensive retinopathy: 20-year follow-up of middle-aged normotensive and hypertensive men. (20010619)
2010
14
Direct ophthalmoscopy versus detection of hypertensive retinopathy: a comparative study. (20602008)
2010
15
Relation between grade II hypertensive retinopathy and coronary artery disease in treated essential hypertensives. (21029012)
2010
16
Prevalence and severity of hypertensive retinopathy in children. (19571332)
2009
17
Malignant hypertension, severe hypertensive retinopathy and malignant nephroangiosclerosis. (18551923)
2008
18
Radiation retinopathy: a mistaken diagnosis of hypertensive retinopathy. (17958571)
2007
19
The relationship between hypertensive retinopathy and Angiotensin converting enzyme gene polymorphism. (16724936)
2006
20
Unilateral malignant hypertensive retinopathy. (16924026)
2006
21
Retinopathy and hypertension affect serum high-sensitivity C-reactive protein levels in Type 2 diabetic patients. (15866055)
2005
22
Malignant hypertensive retinopathy studied with optical coherence tomography. (15805924)
2005
23
Hypertensive retinopathy. (15564546)
2004
24
Hypertensive retinopathy. (14962528)
2004
25
Case 4: eruption on the face of a diabetic man suffering from retinopathy, hypertension, and nephropathy. Diagnosis: ciclosporin-associated hyperplastic folliculitis. (12780737)
2003
26
Hypertensive retinopathy in a cat. (12650046)
2003
27
Bilateral renal artery stenosis presenting as hypertensive retinopathy and choroidopathy. (12355701)
2002
28
Treatment of hypertensive retinopathy. (12431701)
2002
29
Hypertensive retinopathy and pre-eclampsia. (11817020)
2001
30
Is leptin associated with hypertensive retinopathy? (10690876)
2000
31
Reversible hypertensive retinopathy in a child with bilateral pheochromocytoma after tumor resection. (11155750)
2000
32
Diagnostic ophthalmology. Hypertensive retinopathy. (9262864)
1997
33
Hypertensive retinopathy: a review of existing classification systems and a suggestion for a simplified grading system. (8867562)
1996
34
High prevalence of hypertensive retinopathy and coronary heart disease in hypertensive patients with persistent microalbuminuria under short intensive antihypertensive therapy. (8026113)
1994
35
Resolution of hypertensive retinopathy despite persistent high diastolic pressure. (8434291)
1993
36
Hypertensive retinopathy caused by a rare ovarian tumor: case report and photo essay. (1814990)
1991
37
Hypertensive retinopathy. Introduction. (2748096)
1989
38
Hypertensive retinopathy. (6544301)
1983
39
Hypertensive retinopathy and generalized scleroderma. (7325205)
1981
40
Prevalence of renovascular hypertension in patients with grade III or IV hypertensive retinopathy. (503132)
1979
41
The regression of hypertensive retinopathy. (649917)
1978
42
Editorial: pathogenesis of retinopathy in malignant hypertension. (804912)
1975
43
Hypertensive retinopathy. A prospective hospital study of 100 hypertensive Kenyan Africans. (4845025)
1974
44
Experimental hypertensive retinopathy: ultrastructure. (4998607)
1971
45
Experimental hypertensive retinopathy: circulatory changes. (4998606)
1971
46
Hypertensive retinopathy: a clinical study. (5163781)
1971
47
Fluorescein studies of hypertensive retinopathy. (6072717)
1967
48
THE PATHOLOGY OF COTTON WOOL SPOTS AND CYTOID BODIES IN HYPERTENSIVE RETINOPATHY AND OTHER DISEASES. (14123190)
1963
49
Hypertensive retinopathy and its medical treatment. (13215778)
1954
50
Hypertensive retinopathy in a girl aged 10 years 11 months. (21001842)
1946

Genetic Variations for Hypertensive Retinopathy

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Expression for genes affiliated with Hypertensive Retinopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for genes affiliated with Hypertensive Retinopathy

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12EMD Millipore, 53Reactome
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Pathways related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ADIPOQ, ALB
29.4ALB, FTH1

Compounds for genes affiliated with Hypertensive Retinopathy

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1losartan44 49 28 1113.4ALB
2aopp4410.0ADIPOQ, ALB
3gliclazide44 49 1111.9ADIPOQ, ALB
4olmesartan44 28 1111.9ACE, ADIPOQ
5metoprolol44 28 49 11 2413.9ADIPOQ, ACE
6saquinavir44 1110.9ALB, ADIPOQ
7indapamide44 1110.9ALB, ACE
8rosuvastatin44 49 28 1112.9ADIPOQ, ALB
9fosinopril44 1110.8ACE, ALB
1025-hydroxyvitamin d449.8ADIPOQ, ALB
11lisinopril44 11 2411.8ALB, ACE
12perindopril44 49 1111.8ACE, ALB
13hydrochlorothiazide44 49 28 11 2413.8ALB, ACE
14spironolactone49 44 59 28 1113.8ALB, ACE
15furosemide44 49 59 28 11 2414.7ALB, ACE
16olanzapine49 44 28 11 2413.7ADIPOQ, ALB
17captopril44 28 49 59 1113.7ACE, ALB
18halothane44 28 1111.5FTH1, ALB
19warfarin44 49 11 2412.5ACE, ALB
20ramipril44 1110.5ADIPOQ, ALB, ACE
21valsartan44 59 28 1112.5ACE, ALB, ADIPOQ
22telmisartan44 28 1111.5ADIPOQ, ALB, ACE
23irbesartan44 28 49 1112.5ACE, ALB, ADIPOQ
24candesartan44 28 1111.5ADIPOQ, ALB, ACE
25enalapril44 49 1111.5ADIPOQ, ALB, ACE
26amlodipine44 49 11 2412.5ACE, ALB, ADIPOQ
27kininogen449.4ALB, ACE
28ascorbic acid44 2410.3ADIPOQ, ALB, FTH1
29metformin44 49 1111.2ADIPOQ, ACE
30creatinine449.1ADIPOQ, ALB, ACE
31lipid448.6ADIPOQ, ALB, ACE, FTH1

GO Terms for genes affiliated with Hypertensive Retinopathy

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16Gene Ontology
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Biological processes related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.6ADIPOQ, ALB

Molecular functions related to Hypertensive Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.5ALB, ACE

Products for genes affiliated with Hypertensive Retinopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertensive Retinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet