MCID: HYP008
MIFTS: 40

Hypertensive Retinopathy malady

Categories: Eye diseases

Aliases & Classifications for Hypertensive Retinopathy

Aliases & Descriptions for Hypertensive Retinopathy:

Name: Hypertensive Retinopathy 12 29 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11561
ICD10 33 H35.03
ICD9CM 35 362.11
MeSH 42 D058437
NCIt 47 C3514
UMLS 69 C0152132

Summaries for Hypertensive Retinopathy

MalaCards based summary : Hypertensive Retinopathy is related to lupus erythematosus and iida kannari syndrome. An important gene associated with Hypertensive Retinopathy is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Angiogenesis (CST) and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Amlodipine and Olmesartan have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and heart, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

Related Diseases for Hypertensive Retinopathy

Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 lupus erythematosus 29.4 ACE VWF
2 iida kannari syndrome 10.1 ACE ADIPOQ
3 villous adenoma 10.1 ACE FANCG
4 secretory diarrhea myopathy and deafness 10.1 ACE VWF
5 cetp-related hyperalphalipoproteinemia 10.1 ACE VWF
6 gait apraxia 10.1 ACE ADIPOQ
7 ischemic optic neuropathy 10.1 ACE VWF
8 hypotrichosis simplex 10.1 ACE REN
9 oppositional defiant disorder 10.1 ACE VWF
10 hyperinsulinemic hypoglycemia, familial, 3 10.1 ACE REN
11 carbohydrate metabolic disorder 10.1 ACE REN
12 hypothyroidism, congenital nongoitrous, 5 10.0 ACE REN
13 hypogonadism mitral valve prolapse mental retardation 10.0 ACE REN
14 dientamoebiasis 10.0 ACE REN
15 iris disease 10.0 ACE REN
16 congenital nystagmus 10.0 ACE REN
17 prostate neuroendocrine neoplasm 10.0 ACE REN
18 cascade stomach 10.0 ACE REN
19 malignant hypertension 10.0
20 hyperuricemic nephropathy, familial juvenile 2 10.0 ACE REN
21 chylocele of tunica vaginalis 10.0 ACE REN
22 eastern equine encephalitis 10.0 ACE REN
23 myopia 10.0 ACE REN
24 flat umbilicus familial 10.0 ACE REN
25 petrositis 10.0 ACE REN
26 lymphadenitis 10.0 ACE REN
27 pythiosis 10.0 ACE REN
28 microphthalmia, isolated, with coloboma 7 10.0 ACE REN
29 lipomatosis 10.0 ACE ADIPOQ
30 metachronous kidney wilms' tumor 10.0 ADIPOQ REN
31 pulmonary valve insufficiency 10.0 ACE REN
32 schizotypal personality disorder 10.0 ACE REN
33 retinitis 10.0
34 congenital chloride diarrhea 10.0 ACE VWF
35 clear cell adenocarcinoma 10.0 ACE REN
36 aorta angiosarcoma 10.0 ACE REN
37 pyelonephritis 9.9 ACE REN
38 mixed germ cell-sex cord neoplasm 9.9 ACE REN
39 gastrointestinal lymphoma 9.9 ACE REN
40 pheochromocytoma 9.9
41 macular degeneration, age-related, 12 9.9 ACE ADIPOQ VWF
42 chronic myocardial ischemia 9.9 ACE REN
43 limb ischemia 9.9 ACE ADIPOQ REN
44 diabetic encephalopathy 9.9 ACE ADIPOQ REN
45 peroneal neuropathy 9.8 ACE ADIPOQ REN
46 body dysmorphic disorder 9.8 ACE ADIPOQ REN
47 deafness, autosomal recessive 79 9.8 ACE REN VWF
48 ceroid lipofuscinosis, neuronal, kufs type, adult onset 9.8 ACE REN VWF
49 cervix small cell carcinoma 9.8 ACE REN VWF
50 xanthogranulomatous pyelonephritis 9.8 ACE ADIPOQ REN

Comorbidity relations with Hypertensive Retinopathy via Phenotypic Disease Network (PDN):


Deficiency Anemia Hypertension, Essential
Malignant Essential Hypertension

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to Hypertensive Retinopathy

Symptoms & Phenotypes for Hypertensive Retinopathy

MGI Mouse Phenotypes related to Hypertensive Retinopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 ACE ADIPOQ FTH1 REN VWF
2 hematopoietic system MP:0005397 9.35 REN VWF ACE ADIPOQ FTH1
3 immune system MP:0005387 9.02 ACE ADIPOQ FTH1 REN VWF

Drugs & Therapeutics for Hypertensive Retinopathy

Drugs for Hypertensive Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved Phase 4 88150-42-9 2162
2
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
3
Angiotensin II Phase 4 68521-88-0, 11128-99-7 65143 172198
4 Angiotensin II Type 1 Receptor Blockers Phase 4
5 Angiotensin Receptor Antagonists Phase 4
6 Angiotensinogen Phase 4
7 Antihypertensive Agents Phase 4,Phase 1
8 Bone Density Conservation Agents Phase 4
9 calcium channel blockers Phase 4,Phase 1
10 Calcium, Dietary Phase 4,Phase 1
11
Olmesartan medoxomil Phase 4 144689-63-4 130881
12 Vasodilator Agents Phase 4
13 Angiotensin-Converting Enzyme Inhibitors Phase 1
14
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
15
Carbon monoxide Approved 630-08-0 281
16
Menthol Approved 2216-51-5 16666
17
Glucosamine Approved, Nutraceutical 3416-24-8 439213
18 Immunoglobulin A
19 Antiemetics
20 Anti-Inflammatory Agents
21 Antineoplastic Agents, Hormonal
22 Autonomic Agents
23 BB 1101
24 Dexamethasone 21-phosphate
25 Dexamethasone acetate 1177-87-3
26 Gastrointestinal Agents
27 glucocorticoids
28 HIV Protease Inhibitors
29 Hormone Antagonists
30 Hormones
31 Hormones, Hormone Substitutes, and Hormone Antagonists
32 Peripheral Nervous System Agents
33
protease inhibitors
34 Anticoagulants
35 Antimetabolites
36 Fibrinolytic Agents
37 Glucuronyl glucosamine glycan sulfate
38 Hypoglycemic Agents
39 Hypolipidemic Agents
40 Lipid Regulating Agents

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4
2 Research Study in Patients With Persistent Macular Edema Completed NCT00035906 Phase 2
3 Effect of High Blood Pressure and Antihypertensive Treatment on Brain Functioning in Children Completed NCT00178490 Phase 1
4 Establishment of a Perinatal Database and a Bank of Biological Materials Completed NCT00339235
5 The Significance of Urine UbA52 In the Diagnosis of Diabetic Nephropathy Completed NCT02204280
6 Diameters and Wall-to-lumen Ratio of Retinal Arterioles in Patients With Retinal Vein Occlusion. Completed NCT01789437
7 Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy Recruiting NCT01753648
8 Morbidity in Patients With Hypertension and Obstructive Sleep Apnea Recruiting NCT02270658
9 Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation Recruiting NCT01820117
10 DETECT and Retinal Outcomes in Hypertension Recruiting NCT01815567
11 Korean Registry of Target Organ Damages in Hypertension Recruiting NCT01861080
12 a Population Based Study on Metabolic Syndrome Complications, and Mortality Recruiting NCT02958579
13 Retinal Imaging by Adaptive Optics in Healthy Eyes and During Retinal and General Diseases Recruiting NCT01546181
14 Prospective Metabolic Surgery in T2DM Chinese Subjects Active, not recruiting NCT02217943
15 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Hypertensive Retinopathy

Cochrane evidence based reviews: hypertensive retinopathy

Genetic Tests for Hypertensive Retinopathy

Genetic tests related to Hypertensive Retinopathy:

id Genetic test Affiliating Genes
1 Hypertensive Retinopathy 29

Anatomical Context for Hypertensive Retinopathy

MalaCards organs/tissues related to Hypertensive Retinopathy:

39
Retina, Eye, Heart, Endothelial, Liver, Kidney, Breast

Publications for Hypertensive Retinopathy

Articles related to Hypertensive Retinopathy:

(show top 50) (show all 150)
id Title Authors Year
1
Malignant Hypertensive Retinopathy in an Infant with Mid-Aortic Occlusion. ( 27795862 )
2016
2
Hypertensive retinopathy and cerebral small vessel disease in Amerindians living in rural Ecuador: The Atahualpa Project. ( 27232913 )
2016
3
Review of hypertensive retinopathy. ( 27931746 )
2016
4
Proliferative Hypertensive Retinopathy. ( 26767543 )
2016
5
Consideration of hypertensive retinopathy as an important end-organ damage in patients with hypertension. ( 27465980 )
2016
6
Hypertensive retinopathy in a transgenic angiotensin-based model. ( 27026533 )
2016
7
Multimodal Imaging of Elschnig Spots: A Case of Simultaneous Hypertensive Retinopathy, Choroidopathy, and Neuropathy. ( 27082847 )
2016
8
Malignant hypertensive retinopathy as a presenting sign of an occult dead fetus. ( 26082609 )
2015
9
Tremendous result of bevacizumab in malignant hypertensive retinopathy. ( 25709280 )
2015
10
Hypertensive retinopathy revealing a pheochromocytoma associated with a liver hydatid cyst in a child. ( 25955378 )
2015
11
The Keith-Wagener-Barker and Mitchell-Wong grading systems for hypertensive retinopathy: association with target organ damage in individuals below 55 years. ( 26335430 )
2015
12
7D.08: DETECTING HYPERTENSIVE RETINOPATHY USING RETINAL VASCULAR GEOMETRY. ( 26102655 )
2015
13
Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL. ( 26167496 )
2015
14
Hypertensive Retinopathy as the First Manifestation of Advanced Renal Disease in a Young Patient: Report of a Case. ( 26955342 )
2015
15
Updated classification of hypertensive retinopathy: which role for cardiovascular risk stratification? ( 26425835 )
2015
16
Hypertensive Retinopathy, Choroidopathy, and Optic Neuropathy. ( 26448430 )
2015
17
Relationship of Hypertensive Retinopathy with Mean Platelet Volume Among Hypertensive Patients. ( 26835193 )
2015
18
Bilateral hypertensive retinopathy diagnostic of pheochromocytoma. ( 25443213 )
2015
19
Diabetes retinopathy is a poor predictor for renal and cardiovascular outcomes in comparison with hypertensive retinopathy in patients with chronic kidney disease. ( 26008724 )
2015
20
Bilateral Hypertensive Retinopathy Complicated with Retinal Neovascularization: Panretinal Photocoagulation or Intravitreal Anti-VEGF Treatment? ( 25232335 )
2014
21
The association between endothelial dysfunction and hypertensive retinopathy in essential hypertension. ( 24441931 )
2014
22
Detection of hypertensive retinopathy using vessel measurements and textural features. ( 25571216 )
2014
23
Images in clinical medicine. Hypertensive retinopathy associated with preeclampsia. ( 24552322 )
2014
24
Hypertensive retinopathy and its association with cardiovascular, renal and cerebrovascular morbidity in Congolese patients. ( 25629539 )
2014
25
Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. ( 23148140 )
2013
26
Hypertensive retinopathy: comparing the Keith-Wagener-Barker to a simplified classification. ( 23449021 )
2013
27
Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. ( 23521027 )
2013
28
The association of oxidative stress with hypertensive retinopathy. ( 22571627 )
2013
29
Hypertensive retinopathy and risk of stroke. ( 23940194 )
2013
30
Hypertensive retinopathy: incidence, risk factors, and comorbidities. ( 22468968 )
2012
31
Hypertensive retinopathy in a child caused by pheochromocytoma: identification after a failed school vision screening. ( 22245022 )
2012
32
Grade III or Grade IV Hypertensive Retinopathy with Severely Elevated Blood Pressure. ( 23359839 )
2012
33
Effect of intravitreal bevacizumab (Avastin(Ar)) therapy in malignant hypertensive retinopathy: a report of two cases. ( 22149905 )
2012
34
Restoration of outer segments of foveal photoreceptors after resolution of malignant hypertensive retinopathy. ( 23275917 )
2012
35
Hypertensive retinopathy and visual outcome in hypertensive disorders in pregnancy. ( 23765142 )
2011
36
Relationship of hypertensive retinopathy to thoracic aortic atherosclerosis in patients with severe arterial hypertension. ( 21214413 )
2011
37
Hypertensive retinopathy in a child. ( 20693485 )
2011
38
Microalbuminuria and hypertensive retinopathy among newly diagnosed nondiabetic hypertensive adult Nigerians. ( 22248945 )
2011
39
The association of low-grade systemic inflammation with hypertensive retinopathy. ( 21091359 )
2010
40
Serum ferritin levels correlate with hypertensive retinopathy. ( 20110920 )
2010
41
A case of systemic lupus erythematosus presenting as malignant hypertension with hypertensive retinopathy. ( 20830234 )
2010
42
Support system for the preventive diagnosis of hypertensive retinopathy. ( 21097309 )
2010
43
Relationship between left ventricular hypertrophy, hypertensive retinopathy, microalbuminuria and echocardiographic modalities in newly diagnosed hypertensive patients. ( 20111906 )
2010
44
Blood pressure development and hypertensive retinopathy: 20-year follow-up of middle-aged normotensive and hypertensive men. ( 20010619 )
2010
45
Relation between grade II hypertensive retinopathy and coronary artery disease in treated essential hypertensives. ( 21029012 )
2010
46
Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy. ( 19829016 )
2010
47
Direct ophthalmoscopy versus detection of hypertensive retinopathy: a comparative study. ( 20602008 )
2010
48
Prevalence and severity of hypertensive retinopathy in children. ( 19571332 )
2009
49
Hypertensive retinopathy and sensorineural hearing loss. ( 23120650 )
2009
50
Severe bilateral hypertensive retinopathy and optic neuropathy in a patient with pheochromocytoma. ( 18454411 )
2008

Variations for Hypertensive Retinopathy

Expression for Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for Hypertensive Retinopathy

Pathways related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.1 REN VWF
2
Show member pathways
10.86 ACE REN
3 10.44 ACE REN

GO Terms for Hypertensive Retinopathy

Cellular components related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ACE ADIPOQ FTH1 REN VWF

Biological processes related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.32 ACE REN
2 regulation of blood pressure GO:0008217 9.26 ACE REN
3 cellular response to drug GO:0035690 9.16 ADIPOQ REN
4 beta-amyloid metabolic process GO:0050435 8.96 ACE REN
5 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Hypertensive Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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