MCID: HYP008
MIFTS: 39

Hypertensive Retinopathy

Categories: Eye diseases

Aliases & Classifications for Hypertensive Retinopathy

MalaCards integrated aliases for Hypertensive Retinopathy:

Name: Hypertensive Retinopathy 12 72 28 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11561
ICD10 32 H35.03
ICD9CM 34 362.11
MeSH 41 D058437
NCIt 46 C3514
UMLS 69 C0152132

Summaries for Hypertensive Retinopathy

MalaCards based summary : Hypertensive Retinopathy is related to malignant hypertension and renovascular hypertension. An important gene associated with Hypertensive Retinopathy is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Angiogenesis (CST) and ACE Inhibitor Pathway, Pharmacodynamics. The drugs Angiotensin-Converting Enzyme Inhibitors and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include retina, brain and eye, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

Related Diseases for Hypertensive Retinopathy

Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 malignant hypertension 30.5 ACE REN
2 renovascular hypertension 30.0 ACE REN
3 coronary heart disease 1 29.9 ACE ADIPOQ
4 chronic kidney failure 29.1 ACE REN
5 pre-eclampsia 29.1 ADIPOQ REN VWF
6 hypertension, essential 28.9 ACE ADIPOQ REN VWF
7 heart disease 28.9 ACE ADIPOQ REN VWF
8 arteries, anomalies of 28.7 ACE ADIPOQ REN VWF
9 vascular disease 28.7 ACE ADIPOQ REN VWF
10 idiopathic edema 10.2 ACE ADIPOQ
11 hyporeninemic hypoaldosteronism 10.2 ACE REN
12 renal artery obstruction 10.2 ACE REN
13 hypertension, diastolic 10.2 ACE REN
14 hypoaldosteronism 10.2 ACE REN
15 atrial septal defect 4 10.2 ACE REN
16 orthostatic proteinuria 10.2 ACE REN
17 renal artery disease 10.2 ACE REN
18 angina pectoris 10.2 ACE VWF
19 malignant essential hypertension 10.2 ACE REN
20 anuria 10.2 ACE REN
21 fibromuscular dysplasia 10.2 ACE REN
22 hepatorenal syndrome 10.2 ACE REN
23 renal hypertension 10.2 ACE REN
24 oligohydramnios 10.2 ACE REN
25 arteriolosclerosis 10.2 ADIPOQ REN
26 pure autonomic failure 10.2 ACE REN
27 renal tubular dysgenesis 10.2 ACE REN
28 ureteral disease 10.2 ACE REN
29 pseudohyperkalemia, familial, 2, due to red cell leak 10.2 ACE REN
30 intermittent claudication 10.2 ACE VWF
31 interstitial nephritis 10.1 ACE REN
32 limb ischemia 10.1 ACE VWF
33 coronary stenosis 10.1 ACE VWF
34 apnea, obstructive sleep 10.1 ADIPOQ REN
35 lipid metabolism disorder 10.1 ACE ADIPOQ
36 renal dysplasia 10.1 ACE REN
37 pulmonary edema 10.1 ACE REN
38 hypokalemia 10.1 ACE REN
39 peripheral vascular disease 10.1 ACE VWF
40 urinary system disease 10.1 ACE REN
41 atherosclerosis susceptibility 10.1 ACE ADIPOQ
42 retinitis 10.1
43 iga glomerulonephritis 10.1 ACE REN
44 immune system disease 10.1 ACE VWF
45 acute myocardial infarction 10.0 ACE VWF
46 pheochromocytoma 10.0
47 conn's syndrome 10.0 ACE REN
48 congestive heart failure 9.9 ACE REN
49 sleep apnea 9.9 ACE ADIPOQ REN
50 autosomal dominant polycystic kidney disease 9.9 ACE REN

Comorbidity relations with Hypertensive Retinopathy via Phenotypic Disease Network (PDN):


Deficiency Anemia Hypertension, Essential
Malignant Essential Hypertension

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to Hypertensive Retinopathy

Symptoms & Phenotypes for Hypertensive Retinopathy

MGI Mouse Phenotypes related to Hypertensive Retinopathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 ACE ADIPOQ FTH1 REN VWF
2 hematopoietic system MP:0005397 9.35 ACE ADIPOQ FTH1 REN VWF
3 immune system MP:0005387 9.02 ACE ADIPOQ FTH1 REN VWF

Drugs & Therapeutics for Hypertensive Retinopathy

Drugs for Hypertensive Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Angiotensin-Converting Enzyme Inhibitors Phase 1
2 Antihypertensive Agents Phase 1
3 calcium channel blockers Phase 1
4 Calcium, Dietary Phase 1
5
Carbon monoxide Approved, Investigational 630-08-0 281
6
Menthol Approved 2216-51-5 16666
7
Glucosamine Approved, Investigational, Nutraceutical 3416-24-8 439213
8 Anticoagulants
9 Antimetabolites
10 Fibrinolytic Agents
11 Glucuronyl glucosamine glycan sulfate
12 Hypoglycemic Agents
13 Hypolipidemic Agents
14 Lipid Regulating Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of High Blood Pressure and Antihypertensive Treatment on Brain Functioning in Children Completed NCT00178490 Phase 1 High blood pressure treatment
2 Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation Completed NCT01820117
3 Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy Recruiting NCT01753648
4 Morbidity in Patients With Hypertension and Obstructive Sleep Apnea Recruiting NCT02270658
5 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Hypertensive Retinopathy

Cochrane evidence based reviews: hypertensive retinopathy

Genetic Tests for Hypertensive Retinopathy

Genetic tests related to Hypertensive Retinopathy:

# Genetic test Affiliating Genes
1 Hypertensive Retinopathy 28

Anatomical Context for Hypertensive Retinopathy

MalaCards organs/tissues related to Hypertensive Retinopathy:

38
Retina, Brain, Eye, Heart, Endothelial, Breast, Liver

Publications for Hypertensive Retinopathy

Articles related to Hypertensive Retinopathy:

(show top 50) (show all 157)
# Title Authors Year
1
Arteriovenous ratio and papilledema based hybrid decision support system for detection and grading of hypertensive retinopathy. ( 29249337 )
2018
2
Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy. ( 29441752 )
2018
3
Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults. ( 28577362 )
2017
4
Changes in thickness of central macula and retinal nerve fibre layer in severe hypertensive retinopathy: a 1-year longitudinal study. ( 28975766 )
2017
5
Assessment of left atrium and diastolic dysfunction in patients with hypertensive retinopathy: A real-time three-dimensional echocardiography-based study. ( 28758803 )
2017
6
Hypertensive retinopathy as the initial presentation of neuroblastoma. ( 29260095 )
2017
7
Proliferative Hypertensive Retinopathy. ( 26767543 )
2016
8
Hypertensive retinopathy and cerebral small vessel disease in Amerindians living in rural Ecuador: The Atahualpa Project. ( 27232913 )
2016
9
Multimodal Imaging of Elschnig Spots: A Case of Simultaneous Hypertensive Retinopathy, Choroidopathy, and Neuropathy. ( 27082847 )
2016
10
Consideration of hypertensive retinopathy as an important end-organ damage in patients with hypertension. ( 27465980 )
2016
11
P1113Relationship between left atrium and hypertensive retinopathy in patients with systemic hypertension: a real-time three-dimensional echocardiography-based study. ( 28415121 )
2016
12
Hypertensive retinopathy in a transgenic angiotensin-based model. ( 27026533 )
2016
13
Malignant Hypertensive Retinopathy in an Infant with Mid-Aortic Occlusion. ( 27795862 )
2016
14
Review of hypertensive retinopathy. ( 27931746 )
2016
15
The Keith-Wagener-Barker and Mitchell-Wong grading systems for hypertensive retinopathy: association with target organ damage in individuals below 55 years. ( 26335430 )
2015
16
Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL. ( 26167496 )
2015
17
Tremendous result of bevacizumab in malignant hypertensive retinopathy. ( 25709280 )
2015
18
Updated classification of hypertensive retinopathy: which role for cardiovascular risk stratification? ( 26425835 )
2015
19
Bilateral hypertensive retinopathy diagnostic of pheochromocytoma. ( 25443213 )
2015
20
Diabetes retinopathy is a poor predictor for renal and cardiovascular outcomes in comparison with hypertensive retinopathy in patients with chronic kidney disease. ( 26008724 )
2015
21
7D.08: DETECTING HYPERTENSIVE RETINOPATHY USING RETINAL VASCULAR GEOMETRY. ( 26102655 )
2015
22
Hypertensive retinopathy revealing a pheochromocytoma associated with a liver hydatid cyst in a child. ( 25955378 )
2015
23
Relationship of Hypertensive Retinopathy with Mean Platelet Volume Among Hypertensive Patients. ( 26835193 )
2015
24
Malignant hypertensive retinopathy as a presenting sign of an occult dead fetus. ( 26082609 )
2015
25
Hypertensive Retinopathy as the First Manifestation of Advanced Renal Disease in a Young Patient: Report of a Case. ( 26955342 )
2015
26
Hypertensive Retinopathy, Choroidopathy, and Optic Neuropathy. ( 26448430 )
2015
27
The association between endothelial dysfunction and hypertensive retinopathy in essential hypertension. ( 24441931 )
2014
28
Hypertensive retinopathy and its association with cardiovascular, renal and cerebrovascular morbidity in Congolese patients. ( 25629539 )
2014
29
Bilateral Hypertensive Retinopathy Complicated with Retinal Neovascularization: Panretinal Photocoagulation or Intravitreal Anti-VEGF Treatment? ( 25232335 )
2014
30
Detection of hypertensive retinopathy using vessel measurements and textural features. ( 25571216 )
2014
31
Images in clinical medicine. Hypertensive retinopathy associated with preeclampsia. ( 24552322 )
2014
32
Hypertensive retinopathy: comparing the Keith-Wagener-Barker to a simplified classification. ( 23449021 )
2013
33
Hypertensive retinopathy and risk of stroke. ( 23940194 )
2013
34
The association of oxidative stress with hypertensive retinopathy. ( 22571627 )
2013
35
Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. ( 23521027 )
2013
36
Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. ( 23148140 )
2013
37
Effect of intravitreal bevacizumab (Avastin(Ar)) therapy in malignant hypertensive retinopathy: a report of two cases. ( 22149905 )
2012
38
Restoration of outer segments of foveal photoreceptors after resolution of malignant hypertensive retinopathy. ( 23275917 )
2012
39
Grade III or Grade IV Hypertensive Retinopathy with Severely Elevated Blood Pressure. ( 23359839 )
2012
40
Hypertensive retinopathy in a child caused by pheochromocytoma: identification after a failed school vision screening. ( 22245022 )
2012
41
Hypertensive retinopathy: incidence, risk factors, and comorbidities. ( 22468968 )
2012
42
Relationship of hypertensive retinopathy to thoracic aortic atherosclerosis in patients with severe arterial hypertension. ( 21214413 )
2011
43
Hypertensive retinopathy and visual outcome in hypertensive disorders in pregnancy. ( 23765142 )
2011
44
Hypertensive retinopathy in a child. ( 20693485 )
2011
45
Microalbuminuria and hypertensive retinopathy among newly diagnosed nondiabetic hypertensive adult Nigerians. ( 22248945 )
2011
46
Blood pressure development and hypertensive retinopathy: 20-year follow-up of middle-aged normotensive and hypertensive men. ( 20010619 )
2010
47
Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy. ( 19829016 )
2010
48
Support system for the preventive diagnosis of hypertensive retinopathy. ( 21097309 )
2010
49
The association of low-grade systemic inflammation with hypertensive retinopathy. ( 21091359 )
2010
50
Serum ferritin levels correlate with hypertensive retinopathy. ( 20110920 )
2010

Variations for Hypertensive Retinopathy

Expression for Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for Hypertensive Retinopathy

Pathways related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.1 REN VWF
2
Show member pathways
10.86 ACE REN
3 10.44 ACE REN

GO Terms for Hypertensive Retinopathy

Cellular components related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ACE ADIPOQ FTH1 REN VWF

Biological processes related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.32 ACE REN
2 regulation of blood pressure GO:0008217 9.26 ACE REN
3 cellular response to drug GO:0035690 9.16 ADIPOQ REN
4 amyloid-beta metabolic process GO:0050435 8.96 ACE REN
5 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Hypertensive Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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