MCID: HYP076
MIFTS: 55

Hyperthyroidism malady

Summaries for Hyperthyroidism

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. grave's disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will look at your symptoms, blood tests, and sometimes a thyroid scan. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hyperthyroidism, also known as overactive thyroid, is related to graves' disease and thyroiditis. An important gene associated with Hyperthyroidism is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Allograft rejection. The drugs sodium iodide and sodium iodide i123 and the compounds thyroxine and triiodothyronine have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and homeostasis/metabolism.

Disease Ontology:8 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia:64 Hyperthyroidism, often referred to as an overactive thyroid, is a condition in which the thyroid gland... more...

Aliases & Classifications for Hyperthyroidism

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

hyperthyroidism 8 22 10 45 34 61
overactive thyroid 8


External Ids:

Disease Ontology8 DOID:7998
MeSH35 D006980
NCIt40 C3123

Related Diseases for Hyperthyroidism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the familial hyperthyroidism due to mutations in tsh receptor family:

hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease31.1DIO2, CGA, SHBG, SERPINA7, TSHR, TPO
2thyroiditis30.7TRH, TG, TPO, TSHR, SERPINA7, CGA
3adenoma30.7SHBG, TRHR, TRH, TSHB, TSHR, TPO
4thyrotoxicosis30.7TG, TPO, TSHR, SERPINA7, TRH
5nodular goiter30.6TSHR, TG, TPO
6multinodular goiter30.5TG, TPO, TSHR
7subacute thyroiditis30.5TSHR, TPO, TG
8struma ovarii30.5TG, TSHR
9thyroid adenoma30.5DIO2, SHBG, TG, TPO, TSHR, SERPINA7
10thyroid cancer30.5TG, TSHR, TPO
11myxedema30.4TG, TPO, TSHR
12primary hyperparathyroidism30.4BGLAP, ACP5, ALPP
13exophthalmos30.3TSHR, TRH
14insulin resistance30.3SERPINA6, LSL, DIO2, SHBG, RETN
15autoimmune thyroiditis30.3TPO, TG
16nontoxic goiter30.0TG, TPO, TSHR, BGLAP
17neonatal thyrotoxicosis30.0TSHR
18congenital hypothyroidism29.9TG, TSHR, TSHB, SERPINA7, TPO
19cushing's syndrome29.9BGLAP, LSL, GHRH, TRH, RETN
20diabetes insipidus29.9TRH, GHRH
21pernicious anemia29.9TPO, TG
22panhypopituitarism29.9TSHB
23hypoparathyroidism29.9BGLAP, ALPP
24papillary carcinoma29.9TPO, TSHR, TG
25hypercalcemia29.9ALPP, BGLAP
26acromegaly29.7GHRH, RETN, TRH, TRHR, SHBG, LSL
27osteoporosis29.7BGLAP, LSL, ALPP, ACP5, SHBG
28hyperthyroxinemia29.7TPO, TSHR, SERPINA7, TRH
29anorexia nervosa29.7RETN, SHBG, LSL, GHRH
30endemic goiter29.7TSHR, TPO, TG
31pituitary tumors29.7TRH, GHRH, TRHR, TSHB
32hyperandrogenism29.7LSL, CGA, RETN, SHBG
33plummer's disease29.7TPO, SHBG, TG
34down syndrome29.7TSHR, CGA, TPO
35amenorrhea29.7TRH, SHBG
36hypoglycemia29.7LSL, SERPINA6, GHRH, TRH
37thyroid cancer, anaplastic29.7TPO, TG, TSHR
38coronary heart disease29.7RETN, SHBG
39sepsis29.7RETN, SERPINA7, SERPINA6, LSL
40fibrous dysplasia29.7BGLAP, ALPP
41asthma29.7LPO
42glucose intolerance29.7SHBG, LSL, RETN
43rickets29.7ALPP, BGLAP
44celiac disease29.7TPO, TG
45teratoma29.7CGA, ALPP, TG
46familial hyperthyroidism due to mutations in tsh receptor10.4
47mccune albright syndrome10.3
48mccune–albright syndrome10.3
49hyperthyroidism, familial gestational10.2
50thyroid crisis10.2

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to hyperthyroidism

Clinical Features for Hyperthyroidism

Drugs & Therapeutics for Hyperthyroidism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperthyroidism

Drug clinical trials:

Search ClinicalTrials for Hyperthyroidism

Search NIH Clinical Center for Hyperthyroidism

Search CenterWatch for Hyperthyroidism

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hyperthyroidism

Sources:
22GTR
See all sources

Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism22

Anatomical Context for Hyperthyroidism

Animal Models for Hyperthyroidism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hyperthyroidism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.0DIO2, TPO, ALPP, TSHR, SLCO1C1, CYP7A1
2MP:000537610.7DIO2, TSHR, SERPINA6, SLCO1C1, RETN, CYP7A1

Publications for Hyperthyroidism

Sources:
51PubMed
See all sources

Articles related to Hyperthyroidism:

(show top 50)    (show all 927)
idTitleAuthorsYear
1
Effects of an iodine-restricted food on client-owned cats with hyperthyroidism. (24232246)
2013
2
Thyroid disease in children: part 2 : State-of-the-art imaging in pediatric hyperthyroidism. (24057230)
2013
3
Assessment of bone metabolism in premenopausal females with hyperthyroidism and hypothyroidism. (23450446)
2013
4
Effect of Radioactive Iodine Therapy on Lacrimal Gland Functions in Patients With Hyperthyroidism. (24300361)
2013
5
Generalized lichen amyloidosis and hyperthyroidism: coincidence or association. (24278086)
2013
6
Concealed pheochromocytoma presenting as recurrent acute coronary syndrome with STEMI : Case report of a patient with hyperthyroidism. (23880945)
2013
7
Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function. (23056390)
2012
8
Thyroid cancer in patients with hyperthyroidism. (22334393)
2012
9
Does subclinical hyperthyroidism predispose to cocaine addiction? (22297053)
2012
10
Adrenal function in cats with hyperthyroidism. (22373912)
2012
11
Maternal hyperthyroidism is associated with a decreased incidence of cold-induced ascites in broiler chickens. (22499875)
2012
12
A rare case of lingual thyroid with hyperthyroidism: A case report and review of the literature. (22629516)
2012
13
RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism. (22072613)
2012
14
Cerebral sinus venous thrombosis in a child with hyperthyroidism. (21674756)
2012
15
Management of subclinical hyperthyroidism. (21209045)
2011
16
Isolated right ventricular failure in hyperthyroidism: a clinical dilemma. (22049310)
2011
17
Changes of poststimulatory plasma renin activity in women with hyperthyroidism or hypothyroidism in relation to therapy. (21712789)
2011
18
Lithium carbonate pre-treatment in 131-I therapy of hyperthyroidism. (21751165)
2011
19
Hyperthyroidism enhances 5-HT-induced contraction of the rat pulmonary artery: role of calcium-activated chloride channel activation. (21806982)
2011
20
Hyperthyroidism and venous thrombosis: a casual or causal association? A systematic literature review. (20308227)
2011
21
The Thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidism. (20926532)
2011
22
Overt hyperthyroidism and hypothyroidism during pregnancy. (21857178)
2011
23
Natural history of the transition from euthyroidism to overt autoimmune hypo- or hyperthyroidism: a prospective study. (20956436)
2011
24
Cardiovascular involvement in patients with different causes of hyperthyroidism. (20585347)
2010
25
Hyperthyroidism caused by a germline activating mutation of the thyrotropin receptor gene: difficulties in diagnosis and therapy. (20146656)
2010
26
Clinical update: treatment of hyperthyroidism in Graves' ophthalmopathy. (20467362)
2010
27
A comparison of antineutrophil cytoplasmic antibody prevalence in patients treated and untreated for hyperthyroidism. (21046481)
2010
28
Effect of amiodarone-induced hyperthyroidism on left ventricular outflow obstruction after septal myectomy for hypertrophic cardiomyopathy. (21094372)
2010
29
Vasopressinergic network abnormalities potentiate conditioned anxious state of rats subjected to maternal hyperthyroidism. (20371268)
2010
30
Rare presentations of hyperthyroidism--Basedow's paraplegia and pancytopenia. (19371562)
2009
31
Two cases of hyperthyroidism induced by interferon-alpha therapy for renal cell carcinoma]. (17515071)
2007
32
Acute intermittent porphyria associated with hyperthyroidism. (17022885)
2006
33
TSH-induced hyperthyroidism caused by a pituitary tumor. (16957766)
2006
34
Subclinical hyperthyroidism in patients with nodular goiter represents a hypermetabolic state. (15772905)
2005
35
Antioxidants in patients with hyperthyroidism. (15061353)
2004
36
Subclinical hyperthyroidism in dementia and correlation of the metabolic index in FDG-PET. (15055159)
2003
37
Influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain. (12475371)
2002
38
Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol. (11288984)
2001
39
From gene to disease; thyroid stimulating hormone receptor, hyperthyroidism and hypothyroidism]. (11379397)
2001
40
A Phe 486 thyrotropin receptor mutation in an autonomously functioning follicular carcinoma that was causing hyperthyroidism. (11128715)
2000
41
Normal serum concentrations of sex hormone binding-globulin in patients with hyperthyroidism due to subacute thyroiditis. (9920365)
1998
42
Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. (9854118)
1998
43
The relationship between hyperthyroidism and the distribution of peripheral blood T, NK and B-lymphocytes in multinodular goiter. (8200612)
1994
44
Recurrent polyradiculoneuropathy with hyperthyroidism. (8467845)
1993
45
A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism. (1955520)
1991
46
Treatment of hyperthyroidism due to inappropriate secretion of thyrotropin with the somatostatin analog SMS 201-995. (2491862)
1989
47
Serum angiotensin-converting enzyme. Alterations in hyperthyroidism, hypothyroidism, and subacute thyroiditis. (6313976)
1983
48
Metastatic thyroid cancer with severe hyperthyroidism mimicking independent hyperfunctioning thyroid adenoma, showing transition to water-clear-tumour. (7398590)
1980
49
Correction of the biochemical effects of neonatal hypothyroidism by daily low doses of thyroxine. Comparative effects of hyperthyroidism and these corrections. (716836)
1978
50
Proceedings: A case of pseudohypoparathyroidism with hyperthyroidism. (4844403)
1974

Genetic Variations for Hyperthyroidism

Expression for genes affiliated with Hyperthyroidism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for genes affiliated with Hyperthyroidism

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Hyperthyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8CGA, GHRH, TRHR, TRH, TSHB, TSHR
2
Hide members
10.7TG, TPO, TSHR, TSHB
3
Hide members
10.6TSHR, TSHB, CGA
4
Hide members
10.6TSHR, TSHB
5
Hide members
10.6TG, TPO

Compounds for genes affiliated with Hyperthyroidism

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 2BitterDB, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Hyperthyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1thyroxine45 2412.7BGLAP, LSL, DIO2, LPO, CGA, GHRH
2triiodothyronine4511.5TG, TPO, TSHR, LSL, DIO2, CGA
3estradiol45 11 2413.5SLCO1C1, RETN, TRH, SHBG, GHRH, CGA
4arginine4511.5SERPINA7, SERPINA6, TSHR, TG, TPO, SHBG
5aspartate4511.5TG, TPO, ALPP, TSHR, SHBG, GHRH
6testosterone45 60 11 2414.4SERPINA6, TPO, SERPINA7, RETN, TRH, SHBG
7alanine4511.4SHBG, CGA, TRHR, RETN, SERPINA7, SERPINA6
8lipid4511.4SERPINA6, CYP7A1, GHRH, SERPINA7, ACP5, RETN
9methimazole45 2 1113.4TG, LSL, DIO2, LPO, TRH, SERPINA7
10glucose4511.3TSHR, SERPINA6, SERPINA7, RETN, LSL, CYP7A1
11progesterone45 60 29 11 2415.3SERPINA6, SERPINA7, TSHR, RETN, GHRH, TRH
12creatinine4511.3RETN, ACP5, TPO, TG, ALPP, SERPINA7
13ribonucleic acid4511.3SERPINA7, TG, TPO, TSHR, TSHB, SERPINA6
14cholesterol45 29 11 2414.3TPO, TSHR, SERPINA6, SERPINA7, RETN, CYP7A1
15acth4511.3GHRH, LSL, TRH, SERPINA7, TSHR, TPO
16dexamethasone45 50 29 1114.3BGLAP, DIO2, GHRH, SHBG, TRH, CYP7A1
17hydrocortisone45 2 60 1114.3LSL, SHBG, SERPINA6, ALPP, TG, TPO
18estrogen4511.2TRH, DIO2, CYP7A1, TSHR, TG, SERPINA7
19calcium45 50 11 2414.2ALPP, BGLAP, RETN, ACP5, TSHR, TPO
20steroid4511.2TPO, LSL, CGA, GHRH, SHBG, CYP7A1
21tamoxifen45 50 29 1114.2LSL, ALPP, SERPINA6, SERPINA7, CGA, SHBG
22iodine45 2412.2TPO, TG, TSHR, SERPINA7, TRH, DIO2
23prednisolone45 29 1113.2TSHR, SERPINA6, TG, BGLAP, LSL, SHBG
24cysteine4511.2TG, TPO, TSHR, SERPINA6, ACP5, RETN
25125i4511.2TPO, TSHR, SERPINA7, TG, LPO, DIO2
26sialic acid4511.2TG, TSHR, SERPINA6, CGA, LPO, LSL
27iodide45 2412.2SERPINA7, TSHR, DIO2, TPO, LPO, TG
28adenylate4511.1TG, TPO, TSHR, SERPINA6, TRH, SHBG
29carbimazole45 1112.1SHBG, BGLAP, TPO, SERPINA6, TSHR
30ascorbic acid45 2412.1ALPP, BGLAP, TPO, LPO, CGA, TG
31norepinephrine45 11 2413.1TRH, ALPP, RETN, CGA, GHRH
32retinoic acid45 2412.1TG, TSHB, TPO, ALPP, TSHR, CYP7A1
33cycloheximide4511.1DIO2, TRHR, TRH, ALPP, GHRH
34phenytoin45 50 29 1114.0SHBG, SLCO1C1, SERPINA7, CGA, ALPP
35sodium iodide4511.0LPO, TSHR, TG, TPO
36propylthiouracil45 2 1113.0TG, DIO2
37Liothyronine11 2412.0SERPINA7, TPO, DIO2, SLCO1C1
38gnrh4511.0LSL, CGA, GHRH, SHBG, TRH, BGLAP
39deoxypyridinoline4511.0LSL, BGLAP, ACP5
40tibolone4510.9SHBG, LSL, BGLAP, ACP5
41diiodotyrosine4510.9LPO, TG, TPO
42forskolin45 50 1112.9GHRH, RETN, TSHR
43estrone45 29 11 2413.8SERPINA7, LSL, SHBG, SERPINA6, BGLAP
4417-hydroxyprogesterone45 2411.8SHBG, CGA, RETN, SERPINA6
4525-hydroxyvitamin d4510.8ACP5, SHBG, BGLAP, ALPP
46urea45 11 2412.8SERPINA7, RETN, TRH, GHRH, LSL
47vitamin d4510.7BGLAP, ACP5, SHBG, ALPP, CGA, GHRH
48glutamate4510.7ALPP, TG, GHRH, CGA, TSHR, RETN
49carbohydrates4510.7TSHR, TG, SERPINA6, LSL, SHBG
50bromocriptine29 45 1112.4GHRH, CGA, SHBG, TRH

GO Terms for genes affiliated with Hyperthyroidism

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8LPO, GHRH, RETN, SERPINA7, SERPINA6, TG
2extracellular regionGO:00557610.6TG, BGLAP, CGA, GHRH, SHBG, TRH

Biological processes related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.7TG, TPO, CGA, DIO2
2response to vitamin AGO:03318910.6TSHB, SERPINA7
3hormone biosynthetic processGO:04244610.5TG, TPO, DIO2
4cell-cell signalingGO:00726710.4CGA, GHRH, TRH, TSHB, TSHR

Molecular functions related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7TG, TSHB, RETN, CGA

Products for genes affiliated with Hyperthyroidism

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Sources for Hyperthyroidism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet