MCID: HYP076
MIFTS: 62

Hyperthyroidism malady

Genetic diseases, Endocrine diseases, Rare diseases, Cardiovascular diseases, Nephrological diseases, Immune diseases categories

Summaries for Hyperthyroidism

About this section
Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. grave's disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will look at your symptoms, blood tests, and sometimes a thyroid scan. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hyperthyroidism, also known as overactive thyroid, is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroidism is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The drugs sodium iodide and sodium iodide i123 and the compounds flunisolide and desogestrel have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:9 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia:66 Hyperthyroidism, often called overactive thyroid and sometimes hyperthyreosis, is a condition in which... more...

Aliases & Classifications for Hyperthyroidism

About this section
Sources:
9Disease Ontology, 23GTR, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
See all sources

Classifications:



Aliases & Descriptions:

hyperthyroidism 9 23 11 46 35 63
overactive thyroid 9


External Ids:

Disease Ontology9 DOID:7998
MeSH36 D006980
NCIt41 C3123

Related Diseases for Hyperthyroidism

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Familial Hyperthyroidism Due to Mutations in Tsh Receptor family:

hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.5TSHR, SERPINA7, TPO
2hypothyroidism31.2TPO, TSHR
3graves' disease31.1BGLAP, TPO, SERPINA7, TSHR, DIO2
4thyrotoxicosis30.9TPO, SERPINA7, TSHR
5goiter30.8BGLAP, TPO, SERPINA7, TSHR, TSHB, DIO2
6nodular goiter30.7TSHR, TPO
7subacute thyroiditis30.7TSHR, TPO
8adenoma30.6CGB, TRHR, DIO2, TSHB, TSHR, TPO
9multinodular goiter30.6TSHR, TPO
10myxedema30.6TPO, TSHR
11thyroid cancer30.5BGLAP, TPO, TSHR
12hyperparathyroidism30.5BGLAP, ACP5
13thyroid adenoma30.4DIO2, TSHR, SERPINA7, TPO
14autoimmune thyroiditis30.4TPO, SERPINA7, TSHR
15primary hyperparathyroidism30.4BGLAP, ACP5
16follicular thyroid carcinoma30.3DIO2, TSHR, TPO
17pituitary adenoma30.2TRHR, TSHB, SERPINA7
18insulin resistance30.1DIO2, SERPINA6, APOA2
19congenital hypothyroidism30.0TPO, SERPINA7, TSHR, TSHB
20down syndrome30.0TPO, TSHR, CGB
21endemic goiter29.8TSHR, TPO
22papillary thyroid carcinoma29.8TSHR, TPO
23hyperthyroxinemia29.8TPO, SERPINA7, TSHR
24nontoxic goiter29.8BGLAP, TPO, TSHR
25rickets29.8ACP5, BGLAP
26acromegaly29.8CGB, TRHR, BGLAP
27type 1 diabetes mellitus29.7BGLAP, TPO, SERPINA7, TSHR
28polyneuropathy29.7SERPINA7, APOA2
29familial hyperthyroidism due to mutations in tsh receptor10.4
30struma ovarii10.4
31mccune albright syndrome10.3
32hepatitis10.3
33hypertension10.3
34exophthalmos10.2
35hyperthyroidism, familial gestational10.2
36thyroid crisis10.2
37diabetes mellitus10.2
38chromophobe adenoma10.2
39hypokalemic periodic paralysis10.2
40endotheliitis10.2
41pancytopenia10.1
42myasthenia gravis10.1
43myocardial infarction10.1
44chorea10.1
45pituitary tumors10.1
46venous thrombosis10.1
47euthyroid sick syndrome10.1SERPINA7
48camurati-engelmann disease10.1BGLAP
49osteonecrosis10.1BGLAP
50thyroid agenesis10.1TSHR, SERPINA7

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to hyperthyroidism

Symptoms for Hyperthyroidism

About this section

Drugs & Therapeutics for Hyperthyroidism

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperthyroidism

Drug clinical trials:

Search ClinicalTrials for Hyperthyroidism

Search NIH Clinical Center for Hyperthyroidism

Search CenterWatch for Hyperthyroidism

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Hyperthyroidism

About this section
Sources:
23GTR
See all sources

Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism23

Anatomical Context for Hyperthyroidism

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Hyperthyroidism:

34
Thyroid, Bone, Testes, Heart, Kidney, Pituitary, Brain, Liver, Endothelial, Skeletal muscle, Breast, Eye, T cells, Adrenal gland, Bone marrow, Thymus, Fetal brain, B cells, Spinal cord, Myeloid, Smooth muscle, Testis, Skin, Colon, Adipocyte, Lung

Animal Models for Hyperthyroidism or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Hyperthyroidism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5APOA2, TPO, TSHR, DIO2, SLCO1C1, TRHR
2MP:00053766.7TRHR, CYP7A1, APOA2, TPO, SERPINA6, TSHR

Publications for Hyperthyroidism

About this section
Sources:
53PubMed
See all sources

Articles related to Hyperthyroidism:

(show top 50)    (show all 1007)
idTitleAuthorsYear
1
Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism. (23550044)
2013
2
Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism. (23501473)
2013
3
Pivotal roles of risk factors for incident atrial fibrillation in patients with newly diagnosed hyperthyroidism. (23610584)
2013
4
The Incidence of Breast Tumor during Experimental Hyperthyroidism. (24319760)
2013
5
Effect of acute hyperthyroidism on blood flow, muscle oxygenation, and sympathetic nerve activity during dynamic handgrip. (24303102)
2013
6
Total thyroidectomy as primary definitive treatment for graves' hyperthyroidism. (24351357)
2013
7
Metabolic and clinical consequences of hyperthyroidism on bone density. (23970897)
2013
8
Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies. (22975847)
2013
9
Effectiveness of Fixed Dose Radioactive Iodine (RAI) for the Treatment of Hyperthyroidism: Experience of a Teaching Hospital in South West Nigeria. (24003395)
2013
10
The prevalence of TSH receptor germline mutations and clinical courses in 89 hyperthyroid patients with diffuse goiter and negative anti-TSH receptor antibodies. (24279482)
2013
11
Reduced posterior cingulate glutamate measured by magnetic resonance spectroscopy in hyperthyroidism. (23160232)
2012
12
Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function. (23056390)
2012
13
Hyperthyroidism in cats: what's causing this epidemic of thyroid disease and can we prevent it? (23087006)
2012
14
Hyperthyroidism. (22751778)
2012
15
TSI assay utilization: impact on costs of Graves' hyperthyroidism diagnosis. (22435785)
2012
16
Management of subclinical hyperthyroidism. (21209045)
2011
17
Transient hyperthyroidism after surgery for secondary hyperparathyroidism: a common problem. (21813380)
2011
18
Hyperthyroidism presenting with hyperglycemia in an adolescent female. (21823542)
2011
19
Hyperthyroid chorea. (21496587)
2011
20
A practical method for the estimation of therapeutic activity in the treatment of Graves' hyperthyroidism. (21068711)
2011
21
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
22
Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemma. (20064895)
2010
23
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
24
Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas. (20846293)
2010
25
Cardiovascular involvement in patients with different causes of hyperthyroidism. (20585347)
2010
26
Treatment of Graves' hyperthyroidism with thionamides-derived drugs: review. (20843290)
2010
27
Hyperthyroidism unmasked several years after the medical and radiosurgical treatment of an invasive macroprolactinoma inducing hypopituitarism: a case report. (19829805)
2009
28
Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism]. (19569020)
2009
29
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. (18669595)
2008
30
The evaluation of selected oxidative stress parameters in patients with hyperthyroidism]. (17966593)
2007
31
Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal. (14715845)
2004
32
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
33
Similarities and differences in the phenotype of members of an Italian family with hereditary non-autoimmune hyperthyroidism associated with an activating TSH receptor germline mutation. (12240901)
2002
34
E-selectin, L-selectin, ICAM-1 and IL-6 concentrations changes in the serum of patients with hyperthyroidism in the early period of radioiodine I-131 therapy. (14600946)
2002
35
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
36
Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism. (9225730)
1997
37
Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism. (9100552)
1997
38
Coexisting hyperthyroidism and primary hyperparathyroidism with vitamin D-deficient osteomalacia in a Vietnamese immigrant. (15251523)
1996
39
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)
1995
40
Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. (7498500)
1995
41
Effects of chronic iodine administration on thyroid status in euthyroid subjects previously treated with antithyroid drugs for Graves' hyperthyroidism. (7682562)
1993
42
Elevated plasma levels of VWF:Ag in hyperthyroidism are mediated through beta-adrenergic receptors. (8287830)
1993
43
Hyperthyroid hypokalemic periodic paralysis in a Hispanic male. (2304102)
1990
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Thyroid lymphoma in a patient with hyperthyroidism. (6702880)
1984
46
Results of transantral decompression in hyperthyroid exophthalmos. (923413)
1977
47
Long-acting thyroid stimulator (LATS) in hyperthyroidism and exophthalmos. (5392781)
1969
48
Acute porphyria in a hyperthyroid patient. (4185515)
1969
49
Hyperthyroidism and steatorrhea in an adolescent. Report of a case. (4165198)
1967
50
Graves' disease: hyperthyroidism or hyperpituitarism. (13022743)
1952

Variations for Hyperthyroidism

About this section

Expression for genes affiliated with Hyperthyroidism

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for genes affiliated with Hyperthyroidism

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 52PharmGKB
See all sources

Pathways related to Hyperthyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.7TSHR, TPO
3
Show member pathways
9.4TSHB, TSHR, TPO
4
Show member pathways
9.4TPO, TSHR, TSHB
5
Show member pathways
9.3APOA2, CYP7A1
6
Show member pathways
creatine-phosphate biosynthesis39
glycine degradation (creatine biosynthesis)39
putrescine biosynthesis III39
spermidine biosynthesis I39
tryptophan degradation via kynurenine39
spermine biosynthesis39
urea cycle39
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I39
tyrosine degradation I39
L-carnitine biosynthesis39
methylthiopropionate biosynthesis39
2-oxoglutarate decarboxylation to succinyl-CoA39
S-methyl-5-thioadenosine degradation II39
9.3TPO, TSHB, DIO2
7
Show member pathways
7.5CYP7A1, APOA2, TPO, TSHB, DIO2, ACP5

Compounds for genes affiliated with Hyperthyroidism

About this section
Sources:
52PharmGKB, 46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
See all sources

Compounds related to Hyperthyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1flunisolide52 46 1212.0SERPINA6, BGLAP
2desogestrel46 1211.0SERPINA7, SERPINA6
3sodium iodide4610.0TPO, TSHR
4Taurocholic acid25 1210.9CYP7A1, SLCO1C1
5amino acid469.9TSHR, TPO
6maltose46 1210.9TPO, TSHR
7tartrate469.8BGLAP, ACP5
8corticosterone46 62 2511.7SERPINA6, SERPINA7, BGLAP
9prednisolone46 30 1211.7BGLAP, SERPINA6, TSHR
10propylthiouracil46 3 1211.7DIO2, TSHR, TPO
11estrone46 30 25 1212.7SERPINA6, SERPINA7, BGLAP
12sialic acid469.7TSHR, SERPINA6, SERPINA7
13clodronate46 52 1211.7ACP5, BGLAP
14cyproteroneacetate469.7BGLAP, SERPINA6
15chloramphenicol46 3 52 1212.7CYP7A1, SERPINA7, TSHR, TSHB
16tibolone469.6ACP5, BGLAP
17iodine46 2510.5DIO2, TSHR, SERPINA7, TPO
18iodide46 2510.5TPO, SERPINA7, TSHR, DIO2
19liothyronine52 25 1211.5TPO, SERPINA7, DIO2, SLCO1C1
20hydrocortisone46 3 62 1212.5SERPINA6, TPO, BGLAP
21levonorgestrel46 62 30 1212.4SERPINA6, SERPINA7
22carbimazole46 1210.4TSHR, SERPINA6, TPO, BGLAP
23tetracycline46 1210.3BGLAP, TPO, ACP5
24asparagine469.3TPO, SERPINA7, TSHR, CGB
25methimazole46 3 1211.2BGLAP, TPO, SERPINA7, TSHR, DIO2
26polyacrylamide469.1ACP5, SERPINA6, SERPINA7, CYP7A1
27acth469.1TPO, SERPINA7, SERPINA6, TSHR, TSHB
28agarose469.0TSHR, SERPINA7, TPO, APOA2
29progesterone46 30 62 25 1213.0CGB, TSHR, SERPINA6, SERPINA7, CYP7A1
30steroid468.9SERPINA6, SERPINA7, TPO, CYP7A1
31aspartate468.9BGLAP, TPO, SERPINA7, TSHR, ACP5
32testosterone46 62 25 1211.7BGLAP, TPO, SERPINA7, SERPINA6, CGB
33ribonucleic acid468.7TPO, SERPINA7, SERPINA6, TSHR, TSHB, DIO2
34dexamethasone46 52 30 1211.7CYP7A1, BGLAP, SERPINA6, DIO2, ACP5
35125i468.7APOA2, TPO, SERPINA7, TSHR, DIO2
36creatinine468.6BGLAP, TPO, SERPINA7, ACP5, CGB
37tyrosine468.4CYP7A1, TPO, SERPINA7, TSHR, DIO2, ACP5
38serine468.3BGLAP, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
39alanine468.3BGLAP, SERPINA7, SERPINA6, TSHR, DIO2, TRHR
40arginine468.2BGLAP, APOA2, TPO, SERPINA7, SERPINA6, TSHR
41cholesterol46 30 25 1211.2CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
42estradiol46 25 1210.2BGLAP, SERPINA7, SERPINA6, TSHR, ACP5, SLCO1C1
43retinoic acid46 259.0CYP7A1, BGLAP, APOA2, TPO, TSHR, TSHB
44calcium46 52 25 1210.9BGLAP, TPO, TSHR, DIO2, ACP5, TRHR
45glucose467.8CYP7A1, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
46cysteine467.8BGLAP, TPO, SERPINA6, TSHR, DIO2, ACP5
47thyroxine46 258.6CGB, BGLAP, SLCO1C1, DIO2, TSHB, TSHR
48triiodothyronine467.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
49lipid467.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
50estrogen466.6CYP7A1, BGLAP, APOA2, SERPINA7, SERPINA6, TSHR

GO Terms for genes affiliated with Hyperthyroidism

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2CGB, TSHB, SERPINA7, APOA2, BGLAP

Biological processes related to Hyperthyroidism according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin AGO:03318910.1TSHB, SERPINA7
2hormone biosynthetic processGO:0424469.8DIO2, TPO
3peptide hormone processingGO:0164869.8CGB, TSHB
4thyroid hormone generationGO:0065909.8TPO, DIO2
5regulation of proteolysisGO:0301629.7SERPINA6, SERPINA7
6cell-cell signalingGO:0072679.5CGB, TSHB, TSHR
7cholesterol homeostasisGO:0426329.3APOA2, CYP7A1
8response to estrogenGO:0436279.3TSHB, APOA2, BGLAP
9G-protein coupled receptor signaling pathwayGO:0071869.2TRHR, TSHB, TSHR
10response to drugGO:0424939.0BGLAP, APOA2, SERPINA7
11small molecule metabolic processGO:0442817.9CYP7A1, APOA2, TPO, DIO2, ACP5

Products for genes affiliated with Hyperthyroidism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperthyroidism

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet