MCID: HYP076
MIFTS: 54

Hyperthyroidism malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Nephrological diseases, Endocrine diseases, Immune diseases categories

Summaries for Hyperthyroidism

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MedlinePlus:32 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. grave's disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will look at your symptoms, blood tests, and sometimes a thyroid scan. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Hyperthyroidism, also known as overactive thyroid, is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroidism is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The drugs sodium iodide and sodium iodide i123 and the compounds flunisolide and desogestrel have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and heart, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:9 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia:63 Hyperthyroidism, also known as overactive thyroid and hyperthyreosis, is a condition in which the... more...

Aliases & Classifications for Hyperthyroidism

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Hyperthyroidism, Aliases & Descriptions:

Name: Hyperthyroidism 9 11 43 22 32 60
 
Overactive Thyroid 9


Classifications:



External Ids:

Disease Ontology9 DOID:7998
ICD9CM27 242.90
NCIt38 C3123
MeSH33 D006980

Related Diseases for Hyperthyroidism

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Diseases in the Hyperthyroidism family:

Familial Hyperthyroidism Due to Mutations in Tsh Receptor

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7TSHR, SERPINA7, TPO
2hypothyroidism31.5TPO, TSHR
3thyrotoxicosis31.1TPO, SERPINA7, TSHR
4nodular goiter31.1TSHR, TPO
5subacute thyroiditis31.0TSHR, TPO
6multinodular goiter31.0TSHR, TPO
7graves' disease31.0BGLAP, TPO, SERPINA7, TSHR, DIO2
8myxedema30.9TPO, TSHR
9thyroid cancer30.7BGLAP, TPO, TSHR
10primary hyperparathyroidism30.6BGLAP, ACP5
11goiter30.6BGLAP, TPO, SERPINA7, TSHR, TSHB, DIO2
12hyperparathyroidism30.6BGLAP, ACP5
13thyroid adenoma30.5DIO2, TSHR, SERPINA7, TPO
14pituitary adenoma30.5TRHR, TSHB, SERPINA7
15endemic goiter30.2TSHR, TPO
16adenoma30.2CGB, TRHR, DIO2, TSHB, TSHR, TPO
17gestational trophoblastic neoplasm30.1TSHR, CGB
18congenital hypothyroidism30.1TPO, SERPINA7, TSHR, TSHB
19down syndrome30.1TPO, TSHR, CGB
20hyperthyroxinemia30.0TPO, SERPINA7, TSHR
21nontoxic goiter30.0BGLAP, TPO, TSHR
22osteoporosis30.0BGLAP, ACP5
23rickets29.9ACP5, BGLAP
24acromegaly29.9CGB, TRHR, BGLAP
25polyneuropathy29.8SERPINA7, APOA2
26euthyroid sick syndrome10.5SERPINA7
27camurati-engelmann disease10.5BGLAP
28osteonecrosis10.5BGLAP
29atrial fibrillation10.4
30hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.4TSHR, SERPINA7
31struma ovarii10.4
32familial hyperthyroidism due to mutations in tsh receptor10.4
33pendred syndrome10.4TPO
34hyperthyroidism, familial gestational10.4
35hepatitis10.4
36autoimmune thyroiditis10.3
37toxic diffuse goiter10.3TPO, TSHR
38hyperthyroidism, nonautoimmune10.3
39hypothryoidism, congenital, nongoitrous 410.3TPO, TSHB
40adrenal gland hyperfunction10.3BGLAP, SERPINA6
41exophthalmos10.3
42thyroid carcinoma, papillary10.3TSHR, TPO
43endotheliitis10.2
44marchiafava bignami disease10.2ACP5, BGLAP
45renal osteodystrophy10.2ACP5, BGLAP
46pregnancy loss, recurrent 110.2TPO, SERPINA7
47thyroid cancer, anaplastic10.2TSHR, TPO
48thyroid crisis10.2
49pancytopenia10.2
50chromophobe adenoma10.2

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to hyperthyroidism

Symptoms for Hyperthyroidism

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Drugs & Therapeutics for Hyperthyroidism

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Drug clinical trials:

Search ClinicalTrials for Hyperthyroidism

Search NIH Clinical Center for Hyperthyroidism

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hyperthyroidism

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Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism22

Anatomical Context for Hyperthyroidism

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MalaCards organs/tissues related to Hyperthyroidism:

31
Thyroid, Bone, Heart, Testes, Kidney, Pituitary, Brain, Liver, Endothelial, Skeletal muscle, Eye, Breast, T cells, Bone marrow, Thymus, Adrenal gland, Skin, Spinal cord, Smooth muscle, Colon, Lung, Testis, Myeloid, B cells, Fetal brain, Neutrophil

Animal Models for Hyperthyroidism or affiliated genes

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MGI Mouse Phenotypes related to Hyperthyroidism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5APOA2, TPO, TSHR, DIO2, SLCO1C1, TRHR
2MP:00053766.7TRHR, CYP7A1, APOA2, TPO, SERPINA6, TSHR

Publications for Hyperthyroidism

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Articles related to Hyperthyroidism:

(show top 50)    (show all 1052)
idTitleAuthorsYear
1
Methimazole associated neutropenia in a preterm neonate treated for hyperthyroidism. (25810932)
2015
2
Acute psychosis in a pregnant patient with Graves' hyperthyroidism and anti-NMDA receptor encephalitis. (25903201)
2015
3
Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism. (23550044)
2013
4
Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism. (23501473)
2013
5
Pivotal roles of risk factors for incident atrial fibrillation in patients with newly diagnosed hyperthyroidism. (23610584)
2013
6
The Incidence of Breast Tumor during Experimental Hyperthyroidism. (24319760)
2013
7
Effect of acute hyperthyroidism on blood flow, muscle oxygenation, and sympathetic nerve activity during dynamic handgrip. (24303102)
2013
8
Total thyroidectomy as primary definitive treatment for graves' hyperthyroidism. (24351357)
2013
9
Metabolic and clinical consequences of hyperthyroidism on bone density. (23970897)
2013
10
Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies. (22975847)
2013
11
Effectiveness of Fixed Dose Radioactive Iodine (RAI) for the Treatment of Hyperthyroidism: Experience of a Teaching Hospital in South West Nigeria. (24003395)
2013
12
The prevalence of TSH receptor germline mutations and clinical courses in 89 hyperthyroid patients with diffuse goiter and negative anti-TSH receptor antibodies. (24279482)
2013
13
Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function. (23056390)
2012
14
Hyperthyroidism in cats: what's causing this epidemic of thyroid disease and can we prevent it? (23087006)
2012
15
Hyperthyroidism. (22751778)
2012
16
TSI assay utilization: impact on costs of Graves' hyperthyroidism diagnosis. (22435785)
2012
17
Management of subclinical hyperthyroidism. (21209045)
2011
18
Transient hyperthyroidism after surgery for secondary hyperparathyroidism: a common problem. (21813380)
2011
19
Hyperthyroidism presenting with hyperglycemia in an adolescent female. (21823542)
2011
20
Hyperthyroid chorea. (21496587)
2011
21
A practical method for the estimation of therapeutic activity in the treatment of Graves' hyperthyroidism. (21068711)
2011
22
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
23
Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemma. (20064895)
2010
24
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
25
Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas. (20846293)
2010
26
Cardiovascular involvement in patients with different causes of hyperthyroidism. (20585347)
2010
27
Hyperthyroidism unmasked several years after the medical and radiosurgical treatment of an invasive macroprolactinoma inducing hypopituitarism: a case report. (19829805)
2009
28
Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism]. (19569020)
2009
29
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. (18669595)
2008
30
The evaluation of selected oxidative stress parameters in patients with hyperthyroidism]. (17966593)
2007
31
18q deletion syndrome associated with autoimmune thyroid disease presenting as hyperthyroidism. (15844478)
2005
32
Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal. (14715845)
2004
33
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
34
Similarities and differences in the phenotype of members of an Italian family with hereditary non-autoimmune hyperthyroidism associated with an activating TSH receptor germline mutation. (12240901)
2002
35
E-selectin, L-selectin, ICAM-1 and IL-6 concentrations changes in the serum of patients with hyperthyroidism in the early period of radioiodine I-131 therapy. (14600946)
2002
36
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
37
Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism. (9225730)
1997
38
Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism. (9100552)
1997
39
Coexisting hyperthyroidism and primary hyperparathyroidism with vitamin D-deficient osteomalacia in a Vietnamese immigrant. (15251523)
1996
40
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)
1995
41
Effects of chronic iodine administration on thyroid status in euthyroid subjects previously treated with antithyroid drugs for Graves' hyperthyroidism. (7682562)
1993
42
Elevated plasma levels of VWF:Ag in hyperthyroidism are mediated through beta-adrenergic receptors. (8287830)
1993
43
Hyperthyroid hypokalemic periodic paralysis in a Hispanic male. (2304102)
1990
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Thyroid lymphoma in a patient with hyperthyroidism. (6702880)
1984
46
Results of transantral decompression in hyperthyroid exophthalmos. (923413)
1977
47
Long-acting thyroid stimulator (LATS) in hyperthyroidism and exophthalmos. (5392781)
1969
48
Acute porphyria in a hyperthyroid patient. (4185515)
1969
49
Hyperthyroidism and steatorrhea in an adolescent. Report of a case. (4165198)
1967
50
Graves' disease: hyperthyroidism or hyperpituitarism. (13022743)
1952

Variations for Hyperthyroidism

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Expression for genes affiliated with Hyperthyroidism

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Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for genes affiliated with Hyperthyroidism

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Pathways related to Hyperthyroidism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.7TSHR, TPO
3
Show member pathways
9.4TSHB, TSHR, TPO
4
Show member pathways
9.4TPO, TSHR, TSHB
5
Show member pathways
9.3APOA2, CYP7A1
6
Show member pathways
creatine-phosphate biosynthesis36
glycine degradation (creatine biosynthesis)36
putrescine biosynthesis III36
spermidine biosynthesis I36
tryptophan degradation via kynurenine36
spermine biosynthesis36
urea cycle36
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I36
tyrosine degradation I36
L-carnitine biosynthesis36
methylthiopropionate biosynthesis36
2-oxoglutarate decarboxylation to succinyl-CoA36
S-methyl-5-thioadenosine degradation II36
9.3TPO, TSHB, DIO2
7
Show member pathways
7.5CYP7A1, APOA2, TPO, TSHB, DIO2, ACP5

Compounds for genes affiliated with Hyperthyroidism

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Compounds related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1flunisolide49 43 1212.0SERPINA6, BGLAP
2desogestrel43 1211.0SERPINA7, SERPINA6
3sodium iodide4310.0TPO, TSHR
4Taurocholic acid24 1210.9CYP7A1, SLCO1C1
5amino acid439.9TSHR, TPO
6maltose43 1210.9TPO, TSHR
7tartrate439.8BGLAP, ACP5
8corticosterone43 59 2411.7SERPINA6, SERPINA7, BGLAP
9prednisolone43 28 1211.7BGLAP, SERPINA6, TSHR
10propylthiouracil43 2 1211.7DIO2, TSHR, TPO
11estrone43 28 24 1212.7SERPINA6, SERPINA7, BGLAP
12sialic acid439.7TSHR, SERPINA6, SERPINA7
13clodronate43 49 1211.7ACP5, BGLAP
14cyproteroneacetate439.7BGLAP, SERPINA6
15chloramphenicol43 2 49 1212.7CYP7A1, SERPINA7, TSHR, TSHB
16tibolone439.6ACP5, BGLAP
17iodine43 2410.5DIO2, TSHR, SERPINA7, TPO
18iodide43 2410.5TPO, SERPINA7, TSHR, DIO2
19liothyronine49 24 1211.5TPO, SERPINA7, DIO2, SLCO1C1
20hydrocortisone43 2 59 1212.5SERPINA6, TPO, BGLAP
21levonorgestrel43 59 28 1212.4SERPINA6, SERPINA7
22carbimazole43 1210.4TSHR, SERPINA6, TPO, BGLAP
23tetracycline43 1210.3BGLAP, TPO, ACP5
24asparagine439.3TPO, SERPINA7, TSHR, CGB
25methimazole43 2 1211.2BGLAP, TPO, SERPINA7, TSHR, DIO2
26polyacrylamide439.1ACP5, SERPINA6, SERPINA7, CYP7A1
27acth439.1TPO, SERPINA7, SERPINA6, TSHR, TSHB
28agarose439.0TSHR, SERPINA7, TPO, APOA2
29progesterone43 28 59 24 1213.0CGB, TSHR, SERPINA6, SERPINA7, CYP7A1
30steroid438.9SERPINA6, SERPINA7, TPO, CYP7A1
31aspartate438.9BGLAP, TPO, SERPINA7, TSHR, ACP5
32testosterone43 59 24 1211.7BGLAP, TPO, SERPINA7, SERPINA6, CGB
33ribonucleic acid438.7TPO, SERPINA7, SERPINA6, TSHR, TSHB, DIO2
34dexamethasone43 49 28 1211.7CYP7A1, BGLAP, SERPINA6, DIO2, ACP5
35125i438.7APOA2, TPO, SERPINA7, TSHR, DIO2
36creatinine438.6BGLAP, TPO, SERPINA7, ACP5, CGB
37tyrosine438.4CYP7A1, TPO, SERPINA7, TSHR, DIO2, ACP5
38serine438.3BGLAP, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
39alanine438.3BGLAP, SERPINA7, SERPINA6, TSHR, DIO2, TRHR
40arginine438.2BGLAP, APOA2, TPO, SERPINA7, SERPINA6, TSHR
41cholesterol43 28 24 1211.2CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
42estradiol43 24 1210.2BGLAP, SERPINA7, SERPINA6, TSHR, ACP5, SLCO1C1
43retinoic acid43 249.0CYP7A1, BGLAP, APOA2, TPO, TSHR, TSHB
44calcium43 49 24 1210.9BGLAP, TPO, TSHR, DIO2, ACP5, TRHR
45glucose437.8CYP7A1, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
46cysteine437.8BGLAP, TPO, SERPINA6, TSHR, DIO2, ACP5
47thyroxine43 248.6CGB, BGLAP, SLCO1C1, DIO2, TSHB, TSHR
48triiodothyronine437.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
49lipid437.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
50estrogen436.6CYP7A1, BGLAP, APOA2, SERPINA7, SERPINA6, TSHR

GO Terms for genes affiliated with Hyperthyroidism

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Cellular components related to Hyperthyroidism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.2CGB, TSHB, SERPINA7, APOA2, BGLAP

Biological processes related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin AGO:003318910.1TSHB, SERPINA7
2hormone biosynthetic processGO:00424469.8DIO2, TPO
3peptide hormone processingGO:00164869.8CGB, TSHB
4thyroid hormone generationGO:00065909.8TPO, DIO2
5regulation of proteolysisGO:00301629.7SERPINA6, SERPINA7
6cell-cell signalingGO:00072679.5CGB, TSHB, TSHR
7cholesterol homeostasisGO:00426329.3APOA2, CYP7A1
8response to estrogenGO:00436279.3TSHB, APOA2, BGLAP
9G-protein coupled receptor signaling pathwayGO:00071869.2TRHR, TSHB, TSHR
10response to drugGO:00424939.0BGLAP, APOA2, SERPINA7
11small molecule metabolic processGO:00442817.9CYP7A1, APOA2, TPO, DIO2, ACP5

Products for genes affiliated with Hyperthyroidism

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Sources for Hyperthyroidism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet