MCID: HYP076
MIFTS: 62

Hyperthyroidism malady

Genetic diseases, Endocrine diseases, Rare diseases, Cardiovascular diseases, Nephrological diseases, Immune diseases categories
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Summaries for Hyperthyroidism

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8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. grave's disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will look at your symptoms, blood tests, and sometimes a thyroid scan. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hyperthyroidism, also known as overactive thyroid, is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroidism is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The drugs sodium iodide and sodium iodide i123 and the compounds flunisolide and desogestrel have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:8 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia:65 Hyperthyroidism, often called overactive thyroid and sometimes hyperthyreosis, is a condition in which... more...

Aliases & Classifications for Hyperthyroidism

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8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:



Aliases & Descriptions:

hyperthyroidism 8 22 10 45 34 62
overactive thyroid 8


External Ids:

Disease Ontology8 DOID:7998
MeSH35 D006980
NCIt40 C3123

Related Diseases for Hyperthyroidism

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17GeneCards, 18GeneDecks
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Diseases in the Familial Hyperthyroidism Due to Mutations in Tsh Receptor family:

hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.5TSHR, SERPINA7, TPO
2hypothyroidism31.2TPO, TSHR
3graves' disease31.1BGLAP, TPO, SERPINA7, TSHR, DIO2
4thyrotoxicosis30.9TPO, SERPINA7, TSHR
5goiter30.8BGLAP, TPO, SERPINA7, TSHR, TSHB, DIO2
6nodular goiter30.7TSHR, TPO
7subacute thyroiditis30.7TSHR, TPO
8adenoma30.6CGB, TRHR, DIO2, TSHB, TSHR, TPO
9multinodular goiter30.6TSHR, TPO
10myxedema30.6TPO, TSHR
11thyroid cancer30.5BGLAP, TPO, TSHR
12hyperparathyroidism30.5BGLAP, ACP5
13thyroid adenoma30.4DIO2, TSHR, SERPINA7, TPO
14autoimmune thyroiditis30.4TPO, SERPINA7, TSHR
15primary hyperparathyroidism30.4BGLAP, ACP5
16follicular thyroid carcinoma30.3DIO2, TSHR, TPO
17pituitary adenoma30.2TRHR, TSHB, SERPINA7
18insulin resistance30.1DIO2, SERPINA6, APOA2
19congenital hypothyroidism30.0TPO, SERPINA7, TSHR, TSHB
20down syndrome30.0TPO, TSHR, CGB
21endemic goiter29.8TSHR, TPO
22papillary thyroid carcinoma29.8TSHR, TPO
23hyperthyroxinemia29.8TPO, SERPINA7, TSHR
24nontoxic goiter29.8BGLAP, TPO, TSHR
25rickets29.8ACP5, BGLAP
26acromegaly29.8CGB, TRHR, BGLAP
27type 1 diabetes mellitus29.7BGLAP, TPO, SERPINA7, TSHR
28polyneuropathy29.7SERPINA7, APOA2
29familial hyperthyroidism due to mutations in tsh receptor10.4
30struma ovarii10.4
31mccune albright syndrome10.3
32hepatitis10.3
33hypertension10.3
34exophthalmos10.2
35hyperthyroidism, familial gestational10.2
36thyroid crisis10.2
37diabetes mellitus10.2
38chromophobe adenoma10.2
39hypokalemic periodic paralysis10.2
40endotheliitis10.2
41pancytopenia10.1
42myasthenia gravis10.1
43myocardial infarction10.1
44chorea10.1
45pituitary tumors10.1
46venous thrombosis10.1
47euthyroid sick syndrome10.1SERPINA7
48camurati-engelmann disease10.1BGLAP
49osteonecrosis10.1BGLAP
50thyroid agenesis10.1TSHR, SERPINA7

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to hyperthyroidism

Symptoms for Hyperthyroidism

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Drugs & Therapeutics for Hyperthyroidism

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hyperthyroidism

Search NIH Clinical Center for Hyperthyroidism

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hyperthyroidism

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22GTR
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Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism22

Anatomical Context for Hyperthyroidism

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33MalaCards
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MalaCards organs/tissues related to Hyperthyroidism:

33
Thyroid, Bone, Testes, Heart, Kidney, Pituitary, Brain, Liver, Endothelial, Skeletal muscle, Breast, Eye, T cells, Adrenal gland, Bone marrow, Thymus, Fetal brain, B cells, Spinal cord, Myeloid, Smooth muscle, Testis, Skin, Colon, Adipocyte, Lung

Animal Models for Hyperthyroidism or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hyperthyroidism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5APOA2, TPO, TSHR, DIO2, SLCO1C1, TRHR
2MP:00053766.7TRHR, CYP7A1, APOA2, TPO, SERPINA6, TSHR

Publications for Hyperthyroidism

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Sources:
52PubMed
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Articles related to Hyperthyroidism:

(show top 50)    (show all 1007)
idTitleAuthorsYear
1
Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism. (23550044)
2013
2
Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism. (23501473)
2013
3
Pivotal roles of risk factors for incident atrial fibrillation in patients with newly diagnosed hyperthyroidism. (23610584)
2013
4
The Incidence of Breast Tumor during Experimental Hyperthyroidism. (24319760)
2013
5
Effect of acute hyperthyroidism on blood flow, muscle oxygenation, and sympathetic nerve activity during dynamic handgrip. (24303102)
2013
6
Total thyroidectomy as primary definitive treatment for graves' hyperthyroidism. (24351357)
2013
7
Metabolic and clinical consequences of hyperthyroidism on bone density. (23970897)
2013
8
Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies. (22975847)
2013
9
Effectiveness of Fixed Dose Radioactive Iodine (RAI) for the Treatment of Hyperthyroidism: Experience of a Teaching Hospital in South West Nigeria. (24003395)
2013
10
The prevalence of TSH receptor germline mutations and clinical courses in 89 hyperthyroid patients with diffuse goiter and negative anti-TSH receptor antibodies. (24279482)
2013
11
Reduced posterior cingulate glutamate measured by magnetic resonance spectroscopy in hyperthyroidism. (23160232)
2012
12
Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function. (23056390)
2012
13
Hyperthyroidism in cats: what's causing this epidemic of thyroid disease and can we prevent it? (23087006)
2012
14
Hyperthyroidism. (22751778)
2012
15
TSI assay utilization: impact on costs of Graves' hyperthyroidism diagnosis. (22435785)
2012
16
Management of subclinical hyperthyroidism. (21209045)
2011
17
Transient hyperthyroidism after surgery for secondary hyperparathyroidism: a common problem. (21813380)
2011
18
Hyperthyroidism presenting with hyperglycemia in an adolescent female. (21823542)
2011
19
Hyperthyroid chorea. (21496587)
2011
20
A practical method for the estimation of therapeutic activity in the treatment of Graves' hyperthyroidism. (21068711)
2011
21
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
22
Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemma. (20064895)
2010
23
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
24
Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas. (20846293)
2010
25
Cardiovascular involvement in patients with different causes of hyperthyroidism. (20585347)
2010
26
Treatment of Graves' hyperthyroidism with thionamides-derived drugs: review. (20843290)
2010
27
Hyperthyroidism unmasked several years after the medical and radiosurgical treatment of an invasive macroprolactinoma inducing hypopituitarism: a case report. (19829805)
2009
28
Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism]. (19569020)
2009
29
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. (18669595)
2008
30
The evaluation of selected oxidative stress parameters in patients with hyperthyroidism]. (17966593)
2007
31
Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal. (14715845)
2004
32
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
33
Similarities and differences in the phenotype of members of an Italian family with hereditary non-autoimmune hyperthyroidism associated with an activating TSH receptor germline mutation. (12240901)
2002
34
E-selectin, L-selectin, ICAM-1 and IL-6 concentrations changes in the serum of patients with hyperthyroidism in the early period of radioiodine I-131 therapy. (14600946)
2002
35
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
36
Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism. (9225730)
1997
37
Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism. (9100552)
1997
38
Coexisting hyperthyroidism and primary hyperparathyroidism with vitamin D-deficient osteomalacia in a Vietnamese immigrant. (15251523)
1996
39
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)
1995
40
Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. (7498500)
1995
41
Effects of chronic iodine administration on thyroid status in euthyroid subjects previously treated with antithyroid drugs for Graves' hyperthyroidism. (7682562)
1993
42
Elevated plasma levels of VWF:Ag in hyperthyroidism are mediated through beta-adrenergic receptors. (8287830)
1993
43
Hyperthyroid hypokalemic periodic paralysis in a Hispanic male. (2304102)
1990
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Thyroid lymphoma in a patient with hyperthyroidism. (6702880)
1984
46
Results of transantral decompression in hyperthyroid exophthalmos. (923413)
1977
47
Long-acting thyroid stimulator (LATS) in hyperthyroidism and exophthalmos. (5392781)
1969
48
Acute porphyria in a hyperthyroid patient. (4185515)
1969
49
Hyperthyroidism and steatorrhea in an adolescent. Report of a case. (4165198)
1967
50
Graves' disease: hyperthyroidism or hyperpituitarism. (13022743)
1952

Variations for Hyperthyroidism

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Expression for genes affiliated with Hyperthyroidism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for genes affiliated with Hyperthyroidism

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 51PharmGKB
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Pathways related to Hyperthyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.7TSHR, TPO
3
Show member pathways
9.4TSHB, TSHR, TPO
4
Show member pathways
9.4TPO, TSHR, TSHB
5
Show member pathways
9.3APOA2, CYP7A1
6
Show member pathways
creatine-phosphate biosynthesis38
glycine degradation (creatine biosynthesis)38
putrescine biosynthesis III38
spermidine biosynthesis I38
tryptophan degradation via kynurenine38
spermine biosynthesis38
urea cycle38
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I38
tyrosine degradation I38
L-carnitine biosynthesis38
methylthiopropionate biosynthesis38
2-oxoglutarate decarboxylation to succinyl-CoA38
S-methyl-5-thioadenosine degradation II38
9.3TPO, TSHB, DIO2
7
Show member pathways
7.5CYP7A1, APOA2, TPO, TSHB, DIO2, ACP5

Compounds for genes affiliated with Hyperthyroidism

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51PharmGKB, 45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Hyperthyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1flunisolide51 45 1112.0SERPINA6, BGLAP
2desogestrel45 1111.0SERPINA7, SERPINA6
3sodium iodide4510.0TPO, TSHR
4Taurocholic acid24 1110.9CYP7A1, SLCO1C1
5amino acid459.9TSHR, TPO
6maltose45 1110.9TPO, TSHR
7tartrate459.8BGLAP, ACP5
8corticosterone45 61 2411.7SERPINA6, SERPINA7, BGLAP
9prednisolone45 29 1111.7BGLAP, SERPINA6, TSHR
10propylthiouracil45 3 1111.7DIO2, TSHR, TPO
11estrone45 29 24 1112.7SERPINA6, SERPINA7, BGLAP
12sialic acid459.7TSHR, SERPINA6, SERPINA7
13clodronate45 51 1111.7ACP5, BGLAP
14cyproteroneacetate459.7BGLAP, SERPINA6
15chloramphenicol45 3 51 1112.7CYP7A1, SERPINA7, TSHR, TSHB
16tibolone459.6ACP5, BGLAP
17iodine45 2410.5DIO2, TSHR, SERPINA7, TPO
18iodide45 2410.5TPO, SERPINA7, TSHR, DIO2
19liothyronine51 24 1111.5TPO, SERPINA7, DIO2, SLCO1C1
20hydrocortisone45 3 61 1112.5SERPINA6, TPO, BGLAP
21levonorgestrel45 61 29 1112.4SERPINA6, SERPINA7
22carbimazole45 1110.4TSHR, SERPINA6, TPO, BGLAP
23tetracycline45 1110.3BGLAP, TPO, ACP5
24asparagine459.3TPO, SERPINA7, TSHR, CGB
25methimazole45 3 1111.2BGLAP, TPO, SERPINA7, TSHR, DIO2
26polyacrylamide459.1ACP5, SERPINA6, SERPINA7, CYP7A1
27acth459.1TPO, SERPINA7, SERPINA6, TSHR, TSHB
28agarose459.0TSHR, SERPINA7, TPO, APOA2
29progesterone45 29 61 24 1113.0CGB, TSHR, SERPINA6, SERPINA7, CYP7A1
30steroid458.9SERPINA6, SERPINA7, TPO, CYP7A1
31aspartate458.9BGLAP, TPO, SERPINA7, TSHR, ACP5
32testosterone45 61 24 1111.7BGLAP, TPO, SERPINA7, SERPINA6, CGB
33ribonucleic acid458.7TPO, SERPINA7, SERPINA6, TSHR, TSHB, DIO2
34dexamethasone45 51 29 1111.7CYP7A1, BGLAP, SERPINA6, DIO2, ACP5
35125i458.7APOA2, TPO, SERPINA7, TSHR, DIO2
36creatinine458.6BGLAP, TPO, SERPINA7, ACP5, CGB
37tyrosine458.4CYP7A1, TPO, SERPINA7, TSHR, DIO2, ACP5
38serine458.3BGLAP, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
39alanine458.3BGLAP, SERPINA7, SERPINA6, TSHR, DIO2, TRHR
40arginine458.2BGLAP, APOA2, TPO, SERPINA7, SERPINA6, TSHR
41cholesterol45 29 24 1111.2CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
42estradiol45 24 1110.2BGLAP, SERPINA7, SERPINA6, TSHR, ACP5, SLCO1C1
43retinoic acid45 249.0CYP7A1, BGLAP, APOA2, TPO, TSHR, TSHB
44calcium45 51 24 1110.9BGLAP, TPO, TSHR, DIO2, ACP5, TRHR
45glucose457.8CYP7A1, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
46cysteine457.8BGLAP, TPO, SERPINA6, TSHR, DIO2, ACP5
47thyroxine45 248.6CGB, BGLAP, SLCO1C1, DIO2, TSHB, TSHR
48triiodothyronine457.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
49lipid457.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
50estrogen456.6CYP7A1, BGLAP, APOA2, SERPINA7, SERPINA6, TSHR

GO Terms for genes affiliated with Hyperthyroidism

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16Gene Ontology
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Cellular components related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2CGB, TSHB, SERPINA7, APOA2, BGLAP

Biological processes related to Hyperthyroidism according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin AGO:03318910.1TSHB, SERPINA7
2hormone biosynthetic processGO:0424469.8DIO2, TPO
3peptide hormone processingGO:0164869.8CGB, TSHB
4thyroid hormone generationGO:0065909.8TPO, DIO2
5regulation of proteolysisGO:0301629.7SERPINA6, SERPINA7
6cell-cell signalingGO:0072679.5CGB, TSHB, TSHR
7cholesterol homeostasisGO:0426329.3APOA2, CYP7A1
8response to estrogenGO:0436279.3TSHB, APOA2, BGLAP
9G-protein coupled receptor signaling pathwayGO:0071869.2TRHR, TSHB, TSHR
10response to drugGO:0424939.0BGLAP, APOA2, SERPINA7
11small molecule metabolic processGO:0442817.9CYP7A1, APOA2, TPO, DIO2, ACP5

Products for genes affiliated with Hyperthyroidism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperthyroidism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet