MCID: HYP076
MIFTS: 61

Hyperthyroidism malady

Summaries for Hyperthyroidism

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. grave's disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will look at your symptoms, blood tests, and sometimes a thyroid scan. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hyperthyroidism, also known as overactive thyroid, is related to thyroiditis and graves' disease. An important gene associated with Hyperthyroidism is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Allograft rejection. The drugs sodium iodide and sodium iodide i123 and the compounds thyroxine and triiodothyronine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Disease Ontology:8 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia:63 Hyperthyroidism, often referred to as an overactive thyroid, is a condition in which the thyroid gland... more...

Aliases & Classifications for Hyperthyroidism

About this section
Sources:
8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

hyperthyroidism 8 22 10 44 33 60
overactive thyroid 8


External Ids:

Disease Ontology8 DOID:7998
MeSH34 D006980
NCIt39 C3123

Related Diseases for Hyperthyroidism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Familial Hyperthyroidism Due to Mutations in Tsh Receptor family:

hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3TG, TPO, TSHR, SERPINA7, TRH, CGA
2graves' disease31.1TPO, TSHR, SERPINA7, SHBG, CGA, DIO2
3hypothyroidism31.0CGA, SHBG, TRH, SERPINA7, TSHR, TPO
4goiter30.9BGLAP, TG, TPO, TSHR, TSHB, SERPINA7
5thyrotoxicosis30.7TG, TPO, TSHR, SERPINA7, TRH
6adenoma30.7TG, TPO, TSHR, TSHB, TRH, TRHR
7nodular goiter30.6TSHR, TPO, TG
8autoimmune thyroiditis30.5TPO, TG
9subacute thyroiditis30.5TSHR, TPO, TG
10struma ovarii30.5TSHR, TG
11thyroid cancer30.5DIO2, TRH, TSHR, TPO, TG
12multinodular goiter30.5TSHR, TPO, TG
13hepatitis30.4SERPINA7, ALPP
14hyperparathyroidism30.4ALPP, ACP5, BGLAP
15myxedema30.4TSHR, TPO, TG
16primary hyperparathyroidism30.4BGLAP, ACP5, ALPP
17hypertension30.4RETN
18pituitary adenoma30.3CGA, GHRH, TRHR, TRH, SERPINA7, TSHB
19exophthalmos30.3TSHR, TRH
20diabetes mellitus30.2ALPP, RETN, SHBG, LSL, BGLAP
21follicular thyroid carcinoma30.2TSHR, TG
22obesity30.0DIO2, LSL, GHRH, SHBG, TRH, SERPINA6
23nontoxic goiter30.0BGLAP, TSHR, TPO, TG
24cholestasis30.0ALPP, SLCO1C1, CYP7A1
25neonatal thyrotoxicosis30.0TSHR
26leukemia30.0ACP5, TSHR, ALPP
27congenital hypothyroidism29.9SERPINA7, TSHB, TSHR, TPO, TG
28down syndrome29.9TPO, TSHR, CGA
29diabetes insipidus29.9TRH, GHRH
30pernicious anemia29.9TPO, TG
31panhypopituitarism29.9TSHB
32hypoparathyroidism29.9ALPP, BGLAP
33papillary carcinoma29.9TSHR, TPO, TG
34papillary thyroid carcinoma29.9TSHR, TPO, TG
35hypercalcemia29.9ALPP, BGLAP
36acromegaly29.6BGLAP, LSL, GHRH, SHBG, TRHR, TRH
37breast cancer29.6LPO, GHRH, SHBG, ACP5, SERPINA6, ALPP
38hypogonadism29.6BGLAP, LSL, CGA, SHBG, TRH
39cushing's syndrome29.6BGLAP, LSL, GHRH, TRH, RETN
40hyperthyroxinemia29.6TPO, TSHR, SERPINA7, TRH
41osteoporosis29.6BGLAP, LSL, SHBG, ACP5, ALPP
42liver cirrhosis29.6LSL, GHRH, RETN, SERPINA7, ALPP
43hypopituitarism29.6CGA, GHRH, SHBG, TRH
44anorexia nervosa29.6LSL, GHRH, SHBG, RETN
45endemic goiter29.6TSHR, TPO, TG
46pituitary tumors29.6TSHB, TRH, TRHR, GHRH
47hyperglycemia29.6TPO, RETN, GHRH, LSL
48hyperandrogenism29.6LSL, CGA, SHBG, RETN
49plummer's disease29.6SHBG, TPO, TG
50amenorrhea29.6TRH, SHBG

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to hyperthyroidism

Clinical Features for Hyperthyroidism

About this section

Drugs & Therapeutics for Hyperthyroidism

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperthyroidism

Drug clinical trials:

Search ClinicalTrials for Hyperthyroidism

Search NIH Clinical Center for Hyperthyroidism

Search CenterWatch for Hyperthyroidism

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperthyroidism

About this section
Sources:
22GTR
See all sources

Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism22

Anatomical Context for Hyperthyroidism

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hyperthyroidism:

32
Thyroid, Bone, Testes, Heart, Kidney, Pituitary, Brain, Liver, Endothelial, Skeletal muscle, Breast, Eye, T cells, Adrenal gland, Bone marrow, Thymus, Fetal brain, B cells, Spinal cord, Myeloid, Smooth muscle, Testis, Skin, Colon, Adipocyte, Lung

Animal Models for Hyperthyroidism or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hyperthyroidism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.0TRH, TRHR, GHRH, CGA, CYP7A1, SLCO1C1
2MP:000537610.7TG, DIO2, CGA, GHRH, TRHR, TRH

Publications for Hyperthyroidism

About this section
Sources:
50PubMed
See all sources

Articles related to Hyperthyroidism:

(show top 50)    (show all 1016)
idTitleAuthorsYear
1
Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies. (22975847)
2013
2
More than just Ta88: diagnostic testing for hyperthyroidism in cats. (23966003)
2013
3
Selenium supplementation for patients with Graves' hyperthyroidism (the GRASS trial): study protocol for a randomized controlled trial. (23782950)
2013
4
Thyroid disease in children: part 2 : State-of-the-art imaging in pediatric hyperthyroidism. (24057230)
2013
5
HbA1c in the diagnosis of diabetes and abnormal glucose tolerance in patients with Graves' hyperthyroidism. (23684448)
2013
6
The results of therapeutic plasma exchange in patients with severe hyperthyroidism: a retrospective multicenter study. (23611685)
2013
7
Cardiovascular morbidity and mortality in surgically treated hyperthyroidism - a nation-wide cohort study with a long-term follow-up. (24304446)
2013
8
Hyperthyroidism and hyperparathyroidism in guinea pigs (Cavia porcellus). (23642869)
2013
9
Hyperthyroid monkeys: a nonhuman primate model of experimental Graves' disease. (24029729)
2013
10
Comments on graves' hyperthyroidism-induced psychosis treated with aripiprazole: a case report. (24064433)
2013
11
Fetuin-A levels in hyperthyroidism. (23644859)
2013
12
Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors. (22004309)
2012
13
Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations. (22490590)
2012
14
RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism. (22072613)
2012
15
A practical method for the estimation of therapeutic activity in the treatment of Graves' hyperthyroidism. (21068711)
2011
16
Assisting the diagnosis of Graves' hyperthyroidism with pattern recognition methods and a set of three routine tests parameters, and their correlations with free T4 levels: Extension to male patients. (21159485)
2011
17
Prolonged inappropriate TSH suppression during hypothyroidism after thyroid ablation in a patient with nonautoimmune familial hyperthyroidism. (21590647)
2011
18
Hyperandrogenism in a set of triplets with modification of clinical course by hyperthyroidism. (22308865)
2011
19
Antithyroid drug regimen for treating Graves' hyperthyroidism. (20091544)
2010
20
Thyrotropin receptor autoantibody measurement following radiometabolic treatment of hyperthyroidism: comparison between different methods. (20418655)
2010
21
Male sex, African American race or ethnicity, and triiodothyronine levels at diagnosis predict weight gain after antithyroid medication and radioiodine therapy for hyperthyroidism. (20350916)
2010
22
Association between radioiodine therapy for Graves' hyperthyroidism and thyroid-associated ophthalmopathy. (20405165)
2010
23
Bilateral mycotic keratitis in a case of hyperthyroidism-induced exophthalmos. (20404474)
2010
24
Isolated pulmonary arterial hypertension-janus' faces of hyperthyroidism. (19949607)
2009
25
The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. (18605962)
2008
26
Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports. (18426598)
2008
27
Subclinical hyperthyroidism due to a thyrotropin receptor (TSHR) gene mutation (S505R). (17129985)
2006
28
TSH-induced hyperthyroidism caused by a pituitary tumor. (16957766)
2006
29
Insulin Autoimmune Syndrome (Hirata's disease): severe hypoglycemic episodes in Graves' hyperthyroidism patient treated with methimazole. (16377854)
2005
30
Different responses to chronic somatostatin analogues in patients with central hyperthyroidism. (15670193)
2005
31
Coeliac disease associated with SjAPgren's syndrome, renal tubular acidosis, primary biliary cirrhosis and autoimmune hyperthyroidism. (15285530)
2004
32
Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients. (15473886)
2004
33
Propylthiouracil-induced overt hepatic injury in patients with hyperthyroidism]. (15171556)
2004
34
Influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain. (12475371)
2002
35
Non-autoimmune hyperthyroidism and hyperfunctioning thyroid adenomas caused by activating mutation of the thyrotropin receptor]. (11857916)
2002
36
Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13. (11502776)
2001
37
Hyperthyroidism in a patient with TSH-producing pituitary adenoma coexisting with thyroid papillary adenocarcinoma. (11228048)
2000
38
Hyperthyroidism after surgery for primary hyperparathyroidism. (10654273)
1999
39
Circulating telopeptide type I is a peripheral marker of thyroid hormone action in hyperthyroidism and during levothyroxine suppressive therapy. (9292943)
1997
40
Sequential liver and bone biochemical changes in hyperthyroidism: prospective controlled follow-up study. (7912472)
1994
41
Effects of chronic iodine administration on thyroid status in euthyroid subjects previously treated with antithyroid drugs for Graves' hyperthyroidism. (7682562)
1993
42
Bone turnover in overt and subclinical hyperthyroidism due to autonomous thyroid adenoma. (1292974)
1992
43
Alterations of human growth hormone binding by rat liver membranes during hypo- and hyperthyroidism. (2293991)
1990
44
Hyperthyroidism: thyroid crisis (storm, thyrotoxic crisis). (2668603)
1989
45
Clinical and subclinical thyroid disorders associated with pernicious anemia. Observations on abnormal thyroid-stimulating hormone levels and on a possible association of blood group O with hyperthyroidism. (7103627)
1982
46
Optic nerve hypoplasia with hyperthyroidism and third nerve palsy. (7283324)
1980
47
Metastatic thyroid cancer with severe hyperthyroidism mimicking independent hyperfunctioning thyroid adenoma, showing transition to water-clear-tumour. (7398590)
1980
48
Struma ovarii--ascitic, hyperthyroid, and asymptomatic syndromes. (5448747)
1970
49
Hyperthyroidism associated with struma ovarii. A rare surgical challenge. (14452688)
1962
50
Myxedema following radioactive iodine therapy of hyperthyroidism. (13749667)
1961

Genetic Variations for Hyperthyroidism

About this section

Expression for genes affiliated with Hyperthyroidism

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for genes affiliated with Hyperthyroidism

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
See all sources

Pathways related to Hyperthyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8CGA, GHRH, TRHR, TRH, TSHB, TSHR
2
Hide members
10.7TG, TPO, TSHR, TSHB
3
Hide members
10.6TSHR, TSHB, CGA
4
Hide members
10.6TSHR, TSHB
5
Hide members
10.6TG, TPO

Compounds for genes affiliated with Hyperthyroidism

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 49PharmGKB
See all sources

Compounds related to Hyperthyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1thyroxine44 2412.7BGLAP, LSL, DIO2, LPO, CGA, GHRH
2triiodothyronine4411.5TG, TPO, TSHR, LSL, DIO2, CGA
3estradiol44 11 2413.5SLCO1C1, RETN, TRH, SHBG, GHRH, CGA
4arginine4411.5SERPINA7, SERPINA6, TSHR, TG, TPO, SHBG
5aspartate4411.5TG, TPO, ALPP, TSHR, SHBG, GHRH
6testosterone44 59 11 2414.4SERPINA6, TPO, SERPINA7, RETN, TRH, SHBG
7alanine4411.4SHBG, CGA, TRHR, RETN, SERPINA7, SERPINA6
8lipid4411.4SERPINA6, CYP7A1, GHRH, SERPINA7, ACP5, RETN
9methimazole44 2 1113.4TG, LSL, DIO2, LPO, TRH, SERPINA7
10glucose4411.3TSHR, SERPINA6, SERPINA7, RETN, LSL, CYP7A1
11progesterone44 59 28 11 2415.3SERPINA6, SERPINA7, TSHR, RETN, GHRH, TRH
12creatinine4411.3RETN, ACP5, TPO, TG, ALPP, SERPINA7
13ribonucleic acid4411.3SERPINA7, TG, TPO, TSHR, TSHB, SERPINA6
14cholesterol44 28 11 2414.3TPO, TSHR, SERPINA6, SERPINA7, RETN, CYP7A1
15acth4411.3GHRH, LSL, TRH, SERPINA7, TSHR, TPO
16dexamethasone44 49 28 1114.3BGLAP, DIO2, GHRH, SHBG, TRH, CYP7A1
17hydrocortisone44 2 59 1114.3LSL, SHBG, SERPINA6, ALPP, TG, TPO
18estrogen4411.2TRH, DIO2, CYP7A1, TSHR, TG, SERPINA7
19calcium44 49 11 2414.2ALPP, BGLAP, RETN, ACP5, TSHR, TPO
20steroid4411.2TPO, LSL, CGA, GHRH, SHBG, CYP7A1
21tamoxifen44 49 28 1114.2LSL, ALPP, SERPINA6, SERPINA7, CGA, SHBG
22iodine44 2412.2TPO, TG, TSHR, SERPINA7, TRH, DIO2
23prednisolone44 28 1113.2TSHR, SERPINA6, TG, BGLAP, LSL, SHBG
24cysteine4411.2TG, TPO, TSHR, SERPINA6, ACP5, RETN
25125i4411.2TPO, TSHR, SERPINA7, TG, LPO, DIO2
26sialic acid4411.2TG, TSHR, SERPINA6, CGA, LPO, LSL
27iodide44 2412.2SERPINA7, TSHR, DIO2, TPO, LPO, TG
28adenylate4411.1TG, TPO, TSHR, SERPINA6, TRH, SHBG
29carbimazole44 1112.1SHBG, BGLAP, TPO, SERPINA6, TSHR
30ascorbic acid44 2412.1ALPP, BGLAP, TPO, LPO, CGA, TG
31norepinephrine44 11 2413.1TRH, ALPP, RETN, CGA, GHRH
32retinoic acid44 2412.1TG, TSHB, TPO, ALPP, TSHR, CYP7A1
33cycloheximide4411.1DIO2, TRHR, TRH, ALPP, GHRH
34phenytoin44 49 28 1114.0SHBG, SLCO1C1, SERPINA7, CGA, ALPP
35sodium iodide4411.0LPO, TSHR, TG, TPO
36propylthiouracil44 2 1113.0TG, DIO2
37Liothyronine11 2412.0SERPINA7, TPO, DIO2, SLCO1C1
38gnrh4411.0LSL, CGA, GHRH, SHBG, TRH, BGLAP
39deoxypyridinoline4411.0LSL, BGLAP, ACP5
40tibolone4410.9SHBG, LSL, BGLAP, ACP5
41diiodotyrosine4410.9LPO, TG, TPO
42forskolin44 49 1112.9GHRH, RETN, TSHR
43estrone44 28 11 2413.8SERPINA7, LSL, SHBG, SERPINA6, BGLAP
4417-hydroxyprogesterone44 2411.8SHBG, CGA, RETN, SERPINA6
4525-hydroxyvitamin d4410.8ACP5, SHBG, BGLAP, ALPP
46urea44 11 2412.8SERPINA7, RETN, TRH, GHRH, LSL
47vitamin d4410.7BGLAP, ACP5, SHBG, ALPP, CGA, GHRH
48glutamate4410.7ALPP, TG, GHRH, CGA, TSHR, RETN
49carbohydrates4410.7TSHR, TG, SERPINA6, LSL, SHBG
50bromocriptine28 44 1112.4GHRH, CGA, SHBG, TRH

GO Terms for genes affiliated with Hyperthyroidism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8LPO, GHRH, RETN, SERPINA7, SERPINA6, TG
2extracellular regionGO:00557610.6TG, BGLAP, CGA, GHRH, SHBG, TRH

Biological processes related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.7TG, TPO, CGA, DIO2
2response to vitamin AGO:03318910.6TSHB, SERPINA7
3hormone biosynthetic processGO:04244610.5TG, TPO, DIO2
4cell-cell signalingGO:00726710.4CGA, GHRH, TRH, TSHB, TSHR

Molecular functions related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7TG, TSHB, RETN, CGA

Products for genes affiliated with Hyperthyroidism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperthyroidism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet