MCID: HYP076
MIFTS: 64

Hyperthyroidism malady

Genetic diseases, Endocrine diseases, Rare diseases, Cardiovascular diseases, Nephrological diseases, Immune diseases categories
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Summaries for Hyperthyroidism

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MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. grave's disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will look at your symptoms, blood tests, and sometimes a thyroid scan. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Hyperthyroidism, also known as overactive thyroid, is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroidism is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The drugs sodium iodide and sodium iodide i123 and the compounds flunisolide and desogestrel have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and heart, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:8 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia:65 Hyperthyroidism, often called overactive thyroid and sometimes hyperthyreosis, is a condition in which... more...

Aliases & Classifications for Hyperthyroidism

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Hyperthyroidism, Aliases & Descriptions:

Name: Hyperthyroidism 8 22 10 44 33 62
 
Overactive Thyroid 8 62


Classifications:



External Ids:

Disease Ontology8 DOID:7998
MeSH34 D006980
NCIt39 C3123

Related Diseases for Hyperthyroidism

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Diseases in the Familial Hyperthyroidism Due to Mutations in Tsh Receptor family:

hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 268)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7TSHR, SERPINA7, TPO
2hypothyroidism31.5TPO, TSHR
3thyrotoxicosis31.1TPO, SERPINA7, TSHR
4nodular goiter31.1TSHR, TPO
5subacute thyroiditis31.0TSHR, TPO
6multinodular goiter31.0TSHR, TPO
7graves' disease31.0BGLAP, TPO, SERPINA7, TSHR, DIO2
8myxedema30.9TPO, TSHR
9autoimmune thyroiditis30.7TPO, SERPINA7, TSHR
10primary hyperparathyroidism30.6BGLAP, ACP5
11goiter30.6BGLAP, TPO, SERPINA7, TSHR, TSHB, DIO2
12hyperparathyroidism30.6BGLAP, ACP5
13follicular thyroid carcinoma30.5DIO2, TSHR, TPO
14pituitary adenoma30.5TRHR, TSHB, SERPINA7
15thyroid adenoma30.4DIO2, TSHR, SERPINA7, TPO
16endemic goiter30.2TSHR, TPO
17adenoma30.1CGB, TRHR, DIO2, TSHB, TSHR, TPO
18papillary thyroid carcinoma30.1TSHR, TPO
19congenital hypothyroidism30.1TPO, SERPINA7, TSHR, TSHB
20down syndrome30.0TPO, TSHR, CGB
21hyperthyroxinemia30.0TPO, SERPINA7, TSHR
22nontoxic goiter30.0BGLAP, TPO, TSHR
23insulin resistance29.9DIO2, SERPINA6, APOA2
24rickets29.9ACP5, BGLAP
25acromegaly29.9CGB, TRHR, BGLAP
26type 1 diabetes mellitus29.8BGLAP, TPO, SERPINA7, TSHR
27polyneuropathy29.8SERPINA7, APOA2
28euthyroid sick syndrome10.5SERPINA7
29camurati-engelmann disease10.5BGLAP
30osteonecrosis10.5BGLAP
31familial hyperthyroidism due to mutations in tsh receptor10.4
32thyroid agenesis10.4TSHR, SERPINA7
33pendred syndrome10.4TPO
34struma ovarii10.4
35hepatitis10.3
36mccune albright syndrome10.3
37thyroid cancer10.3
38hypertension10.3
39toxic diffuse goiter10.3TPO, TSHR
40thyrotropin deficiency, isolated10.3TPO, TSHB
41adrenal gland hyperfunction10.3BGLAP, SERPINA6
42diabetes mellitus10.3
43exophthalmos10.3
44hyperthyroidism, familial gestational10.3
45thyroid crisis10.2
46endotheliitis10.2
47gestational trophoblastic neoplasm10.2TSHR, CGB
48renal osteodystrophy10.2ACP5, BGLAP
49hypokalemic periodic paralysis10.2
50chromophobe adenoma10.2

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to hyperthyroidism

Symptoms for Hyperthyroidism

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Drugs & Therapeutics for Hyperthyroidism

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Drug clinical trials:

Search ClinicalTrials for Hyperthyroidism

Search NIH Clinical Center for Hyperthyroidism

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Hyperthyroidism

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Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism22

Anatomical Context for Hyperthyroidism

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MalaCards organs/tissues related to Hyperthyroidism:

32
Thyroid, Bone, Heart, Testes, Kidney, Pituitary, Brain, Liver, Endothelial, Skeletal muscle, Eye, Breast, T cells, Bone marrow, Thymus, Adrenal gland, Skin, Spinal cord, Smooth muscle, Colon, Adipocyte, Lung, Testis, Myeloid, B cells, Fetal brain, Neutrophil

Animal Models for Hyperthyroidism or affiliated genes

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MGI Mouse Phenotypes related to Hyperthyroidism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5APOA2, TPO, TSHR, DIO2, SLCO1C1, TRHR
2MP:00053766.7TRHR, CYP7A1, APOA2, TPO, SERPINA6, TSHR

Publications for Hyperthyroidism

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Articles related to Hyperthyroidism:

(show top 50)    (show all 1029)
idTitleAuthorsYear
1
Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism. (23550044)
2013
2
Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism. (23501473)
2013
3
Pivotal roles of risk factors for incident atrial fibrillation in patients with newly diagnosed hyperthyroidism. (23610584)
2013
4
The Incidence of Breast Tumor during Experimental Hyperthyroidism. (24319760)
2013
5
Effect of acute hyperthyroidism on blood flow, muscle oxygenation, and sympathetic nerve activity during dynamic handgrip. (24303102)
2013
6
Total thyroidectomy as primary definitive treatment for graves' hyperthyroidism. (24351357)
2013
7
Metabolic and clinical consequences of hyperthyroidism on bone density. (23970897)
2013
8
Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies. (22975847)
2013
9
Effectiveness of Fixed Dose Radioactive Iodine (RAI) for the Treatment of Hyperthyroidism: Experience of a Teaching Hospital in South West Nigeria. (24003395)
2013
10
The prevalence of TSH receptor germline mutations and clinical courses in 89 hyperthyroid patients with diffuse goiter and negative anti-TSH receptor antibodies. (24279482)
2013
11
Reduced posterior cingulate glutamate measured by magnetic resonance spectroscopy in hyperthyroidism. (23160232)
2012
12
Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function. (23056390)
2012
13
Hyperthyroidism in cats: what's causing this epidemic of thyroid disease and can we prevent it? (23087006)
2012
14
Hyperthyroidism. (22751778)
2012
15
TSI assay utilization: impact on costs of Graves' hyperthyroidism diagnosis. (22435785)
2012
16
Management of subclinical hyperthyroidism. (21209045)
2011
17
Transient hyperthyroidism after surgery for secondary hyperparathyroidism: a common problem. (21813380)
2011
18
Hyperthyroidism presenting with hyperglycemia in an adolescent female. (21823542)
2011
19
Hyperthyroid chorea. (21496587)
2011
20
A practical method for the estimation of therapeutic activity in the treatment of Graves' hyperthyroidism. (21068711)
2011
21
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
22
Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemma. (20064895)
2010
23
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
24
Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas. (20846293)
2010
25
Cardiovascular involvement in patients with different causes of hyperthyroidism. (20585347)
2010
26
Hyperthyroidism unmasked several years after the medical and radiosurgical treatment of an invasive macroprolactinoma inducing hypopituitarism: a case report. (19829805)
2009
27
Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism]. (19569020)
2009
28
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. (18669595)
2008
29
The evaluation of selected oxidative stress parameters in patients with hyperthyroidism]. (17966593)
2007
30
18q deletion syndrome associated with autoimmune thyroid disease presenting as hyperthyroidism. (15844478)
2005
31
Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal. (14715845)
2004
32
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
33
Similarities and differences in the phenotype of members of an Italian family with hereditary non-autoimmune hyperthyroidism associated with an activating TSH receptor germline mutation. (12240901)
2002
34
E-selectin, L-selectin, ICAM-1 and IL-6 concentrations changes in the serum of patients with hyperthyroidism in the early period of radioiodine I-131 therapy. (14600946)
2002
35
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
36
Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism. (9225730)
1997
37
Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism. (9100552)
1997
38
Coexisting hyperthyroidism and primary hyperparathyroidism with vitamin D-deficient osteomalacia in a Vietnamese immigrant. (15251523)
1996
39
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)
1995
40
Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. (7498500)
1995
41
Effects of chronic iodine administration on thyroid status in euthyroid subjects previously treated with antithyroid drugs for Graves' hyperthyroidism. (7682562)
1993
42
Elevated plasma levels of VWF:Ag in hyperthyroidism are mediated through beta-adrenergic receptors. (8287830)
1993
43
Hyperthyroid hypokalemic periodic paralysis in a Hispanic male. (2304102)
1990
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Thyroid lymphoma in a patient with hyperthyroidism. (6702880)
1984
46
Results of transantral decompression in hyperthyroid exophthalmos. (923413)
1977
47
Long-acting thyroid stimulator (LATS) in hyperthyroidism and exophthalmos. (5392781)
1969
48
Acute porphyria in a hyperthyroid patient. (4185515)
1969
49
Hyperthyroidism and steatorrhea in an adolescent. Report of a case. (4165198)
1967
50
Graves' disease: hyperthyroidism or hyperpituitarism. (13022743)
1952

Variations for Hyperthyroidism

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Expression for genes affiliated with Hyperthyroidism

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Expression patterns in normal tissues for genes affiliated with Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for genes affiliated with Hyperthyroidism

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Pathways related to Hyperthyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.7TSHR, TPO
3
Show member pathways
9.4TSHB, TSHR, TPO
4
Show member pathways
9.4TPO, TSHR, TSHB
5
Show member pathways
9.3APOA2, CYP7A1
6
Show member pathways
creatine-phosphate biosynthesis37
glycine degradation (creatine biosynthesis)37
putrescine biosynthesis III37
spermidine biosynthesis I37
tryptophan degradation via kynurenine37
spermine biosynthesis37
urea cycle37
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I37
tyrosine degradation I37
L-carnitine biosynthesis37
methylthiopropionate biosynthesis37
2-oxoglutarate decarboxylation to succinyl-CoA37
S-methyl-5-thioadenosine degradation II37
9.3TPO, TSHB, DIO2
7
Show member pathways
7.5CYP7A1, APOA2, TPO, TSHB, DIO2, ACP5

Compounds for genes affiliated with Hyperthyroidism

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Compounds related to Hyperthyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1flunisolide50 44 1112.0SERPINA6, BGLAP
2desogestrel44 1111.0SERPINA7, SERPINA6
3sodium iodide4410.0TPO, TSHR
4Taurocholic acid24 1110.9CYP7A1, SLCO1C1
5amino acid449.9TSHR, TPO
6maltose44 1110.9TPO, TSHR
7tartrate449.8BGLAP, ACP5
8corticosterone44 61 2411.7SERPINA6, SERPINA7, BGLAP
9prednisolone44 28 1111.7BGLAP, SERPINA6, TSHR
10propylthiouracil44 2 1111.7DIO2, TSHR, TPO
11estrone44 28 24 1112.7SERPINA6, SERPINA7, BGLAP
12sialic acid449.7TSHR, SERPINA6, SERPINA7
13clodronate44 50 1111.7ACP5, BGLAP
14cyproteroneacetate449.7BGLAP, SERPINA6
15chloramphenicol44 2 50 1112.7CYP7A1, SERPINA7, TSHR, TSHB
16tibolone449.6ACP5, BGLAP
17iodine44 2410.5DIO2, TSHR, SERPINA7, TPO
18iodide44 2410.5TPO, SERPINA7, TSHR, DIO2
19liothyronine50 24 1111.5TPO, SERPINA7, DIO2, SLCO1C1
20hydrocortisone44 2 61 1112.5SERPINA6, TPO, BGLAP
21levonorgestrel44 61 28 1112.4SERPINA6, SERPINA7
22carbimazole44 1110.4TSHR, SERPINA6, TPO, BGLAP
23tetracycline44 1110.3BGLAP, TPO, ACP5
24asparagine449.3TPO, SERPINA7, TSHR, CGB
25methimazole44 2 1111.2BGLAP, TPO, SERPINA7, TSHR, DIO2
26polyacrylamide449.1ACP5, SERPINA6, SERPINA7, CYP7A1
27acth449.1TPO, SERPINA7, SERPINA6, TSHR, TSHB
28agarose449.0TSHR, SERPINA7, TPO, APOA2
29progesterone44 28 61 24 1113.0CGB, TSHR, SERPINA6, SERPINA7, CYP7A1
30steroid448.9SERPINA6, SERPINA7, TPO, CYP7A1
31aspartate448.9BGLAP, TPO, SERPINA7, TSHR, ACP5
32testosterone44 61 24 1111.7BGLAP, TPO, SERPINA7, SERPINA6, CGB
33ribonucleic acid448.7TPO, SERPINA7, SERPINA6, TSHR, TSHB, DIO2
34dexamethasone44 50 28 1111.7CYP7A1, BGLAP, SERPINA6, DIO2, ACP5
35125i448.7APOA2, TPO, SERPINA7, TSHR, DIO2
36creatinine448.6BGLAP, TPO, SERPINA7, ACP5, CGB
37tyrosine448.4CYP7A1, TPO, SERPINA7, TSHR, DIO2, ACP5
38serine448.3BGLAP, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
39alanine448.3BGLAP, SERPINA7, SERPINA6, TSHR, DIO2, TRHR
40arginine448.2BGLAP, APOA2, TPO, SERPINA7, SERPINA6, TSHR
41cholesterol44 28 24 1111.2CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
42estradiol44 24 1110.2BGLAP, SERPINA7, SERPINA6, TSHR, ACP5, SLCO1C1
43retinoic acid44 249.0CYP7A1, BGLAP, APOA2, TPO, TSHR, TSHB
44calcium44 50 24 1110.9BGLAP, TPO, TSHR, DIO2, ACP5, TRHR
45glucose447.8CYP7A1, APOA2, SERPINA7, SERPINA6, TSHR, DIO2
46cysteine447.8BGLAP, TPO, SERPINA6, TSHR, DIO2, ACP5
47thyroxine44 248.6CGB, BGLAP, SLCO1C1, DIO2, TSHB, TSHR
48triiodothyronine447.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
49lipid447.6CYP7A1, APOA2, TPO, SERPINA7, SERPINA6, TSHR
50estrogen446.6CYP7A1, BGLAP, APOA2, SERPINA7, SERPINA6, TSHR

GO Terms for genes affiliated with Hyperthyroidism

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Cellular components related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2CGB, TSHB, SERPINA7, APOA2, BGLAP

Biological processes related to Hyperthyroidism according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin AGO:03318910.1TSHB, SERPINA7
2hormone biosynthetic processGO:0424469.8DIO2, TPO
3peptide hormone processingGO:0164869.8CGB, TSHB
4thyroid hormone generationGO:0065909.8TPO, DIO2
5regulation of proteolysisGO:0301629.7SERPINA6, SERPINA7
6cell-cell signalingGO:0072679.5CGB, TSHB, TSHR
7cholesterol homeostasisGO:0426329.3APOA2, CYP7A1
8response to estrogenGO:0436279.3TSHB, APOA2, BGLAP
9G-protein coupled receptor signaling pathwayGO:0071869.2TRHR, TSHB, TSHR
10response to drugGO:0424939.0BGLAP, APOA2, SERPINA7
11small molecule metabolic processGO:0442817.9CYP7A1, APOA2, TPO, DIO2, ACP5

Products for genes affiliated with Hyperthyroidism

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Sources for Hyperthyroidism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet