MCID: HYP076
MIFTS: 53

Hyperthyroidism

Categories: Endocrine diseases, Rare diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Hyperthyroidism

MalaCards integrated aliases for Hyperthyroidism:

Name: Hyperthyroidism 12 29 52 41 42 14 69
Overactive Thyroid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7998
ICD10 33 E05.9
MeSH 42 D006980
NCIt 47 C3123
UMLS 69 C0020550

Summaries for Hyperthyroidism

MedlinePlus : 41 your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. graves' disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will do a physical exam, look at your symptoms, and do thyroid tests. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Hyperthyroidism, also known as overactive thyroid, is related to hyperthyroidism, nonautoimmune and kidney disease. An important gene associated with Hyperthyroidism is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Peptide ligand-binding receptors and Allograft rejection. The drugs Propylthiouracil and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and bone, and related phenotypes are Increased HPV16-GFP infection and endocrine/exocrine gland

Disease Ontology : 12 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia : 72 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the... more...

Related Diseases for Hyperthyroidism

Diseases in the Hyperthyroidism family:

Familial Hyperthyroidism Due to Mutations in Tsh Receptor

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
id Related Disease Score Top Affiliating Genes
1 hyperthyroidism, nonautoimmune 34.7 GNAS TSHR
2 kidney disease 30.3 TG TSHR
3 endemic goiter 29.1 BGLAP SERPINA7 SHBG TG TPO TSHR
4 lymphoma 29.1 CTLA4 PRTN3 TG TPO TSHR
5 pseudohypoparathyroidism 28.7 CTLA4 PRTN3 TG TPO TSHR
6 hyperthyroidism, familial gestational 12.3
7 familial hyperthyroidism due to mutations in tsh receptor 12.1
8 graves' disease 11.9
9 congenital craniosynostosis maternal hyperthyroiditis 11.8
10 thyroid hormone resistance, selective pituitary 11.5
11 thyroid crisis 11.1
12 hypothyroidism 11.1
13 struma ovarii 11.0
14 myxedema 11.0
15 thyrotoxic periodic paralysis 1 11.0
16 thyrotoxic periodic paralysis 11.0
17 pituitary tumors 11.0
18 hypoparathyroidism 11.0
19 myopathy - thyrotoxic 11.0
20 adenohypophysitis 10.9 TG TPO
21 maxillary sinus adenoid cystic carcinoma 10.9 TG TPO
22 chronic polyneuropathy 10.8 TG TSHR
23 thyrotoxic periodic paralysis 2 10.8
24 mccune-albright syndrome, somatic, mosaic 10.8
25 rhabdomyosarcoma, embryonal, 2 10.8 TG TPO
26 nephrogenic systemic fibrosis 10.8 TG TPO TSHR
27 panhypophysitis 10.8 TG TSHR
28 obesity, mc4r-related 10.7 GHRL GNAS
29 nodular prostate 10.7 TG TPO TSHR
30 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 10.7 SERPINA7 TG TSHR
31 echinostomiasis 10.7 SERPINA7 TG
32 bladder diffuse clear cell adenocarcinoma 10.7 TG TPO TSHR
33 primary bacterial infectious disease 10.7 TG TPO TSHR
34 gastrointestinal system cancer 10.7 TG TPO TSHR
35 hypobetalipoproteinemia, familial, 2 10.7
36 autoimmune thyroid disease 3 10.7
37 familial periodic paralysis 10.7
38 hypolipoproteinemia 10.7
39 superior limbic keratoconjunctivitis 10.7
40 hyperthyroxinemia, familial dysalbuminemic 10.7
41 chorea, hereditary benign 10.7 TG TPO TSHR
42 atheroembolism of kidney 10.6 TG TRH
43 conjunctival deposit 10.6 CTLA4 TG TPO TSHR
44 combined cellular and humoral immune defects with granulomas 10.6 CTLA4 TG TPO TSHR
45 meningovascular neurosyphilis 10.6 GNAS TG TPO TSHR
46 glaucomatocyclitic crisis 10.6 CTLA4 SST TSHR
47 diabetes mellitus, insulin-dependent, 12 10.5 CTLA4 TG TPO TSHR
48 background diabetic retinopathy 10.5 SERPINA7 TG TPO TSHR
49 thyroiditis 10.5
50 mononeuritis of upper limb and mononeuritis multiplex 10.5 GNAS SST

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to Hyperthyroidism

Symptoms & Phenotypes for Hyperthyroidism

GenomeRNAi Phenotypes related to Hyperthyroidism according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HPV16-GFP infection GR00350-A 8.92 GNAS SDHA SERPINA7 TRH

MGI Mouse Phenotypes related to Hyperthyroidism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 CGA CTLA4 GHRL GNAS LEP PRL
2 homeostasis/metabolism MP:0005376 9.47 GNAS LEP PRL SDHA SERPINA6 SST

Drugs & Therapeutics for Hyperthyroidism

Drugs for Hyperthyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propylthiouracil Approved Phase 4,Phase 3,Phase 2 51-52-5 657298
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
5
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
6
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
7
Timolol Approved Phase 4 26839-75-8 33624 5478
8
Travoprost Approved Phase 4 157283-68-6 5282226
9
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
10
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
12
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
13
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
14
Propranolol Approved, Investigational Phase 4 525-66-6 4946
15
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
16
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294
17
Pseudoephedrine Approved Phase 4,Phase 2 90-82-4 7028
18
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
19
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
20
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
21
Alfacalcidol Approved, Nutraceutical Phase 4,Phase 2 41294-56-8 5282181
22
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 134070 5280453
23
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
24
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 1406-16-2
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-30-3 6037
26
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
27
Maleic acid Experimental Phase 4 110-16-7 444266
28
Iodine Investigational Phase 4,Phase 2,Phase 3 7553-56-2 807
29
Dinoprost Investigational Phase 4 551-11-1 5283078
30 Antimetabolites Phase 4,Phase 3,Phase 2
31 Antithyroid Agents Phase 4,Phase 3,Phase 1,Phase 2
32 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
33 Hormones Phase 4,Phase 2,Phase 3,Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
35 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
36 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
38 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
39 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
41 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
42 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
43 Neuroprotective Agents Phase 4,Phase 2,Phase 3
44 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Prednisolone acetate Phase 4,Phase 2,Phase 3
46 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
47 Prednisolone phosphate Phase 4,Phase 2,Phase 3
48 Protective Agents Phase 4,Phase 2,Phase 3
49 Adrenergic Agents Phase 4,Phase 2
50 Adrenergic Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 179)

id Name Status NCT ID Phase Drugs
1 Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy Unknown status NCT01779817 Phase 4
2 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
3 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
4 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Unknown status NCT01927406 Phase 4 Prostaglandin Analog;Timolol
5 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
6 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
7 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
8 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
9 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
10 Compare the Efficacy of Cinacalcet vs Traditional Vitamin D for Secondary Hyperparathyroidism (SHPT) Among Subjects Undergoing Hemodialysis Completed NCT01181531 Phase 4 Traditional Vitamin D Therapy;Cinacalcet
11 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
12 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
13 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
14 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
15 Levothyroxine Replacement for Subclinical Hypothyroidism and Chronic Heart Failure Recruiting NCT03096613 Phase 4 Levothyroxine
16 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
17 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
18 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
19 Effects of Statins in Graves' Orbitopathy (GO) in Hypercholesterolemic Patients Not yet recruiting NCT03110848 Phase 4 Atorvastatin;Methylprednisolone
20 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
21 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
22 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
23 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Unknown status NCT02155049 Phase 3 bimatoprost 0.03%
24 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
25 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
26 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
27 Early Administration of L-carnitine in Hemodialysis Patients Completed NCT00322322 Phase 3 L-Carnitine
28 Low Salt Diet in Idiopathic Hypercalciuria Completed NCT01005082 Phase 2, Phase 3
29 Percutaneous Radiofrequency Thermal Ablation in Compressive Thyroid Nodules Completed NCT01649206 Phase 3
30 Antithyroid Drug Treatment of Thyrotoxicosis in Young People Completed NCT01436994 Phase 3 carbimazole;propylthiouracil;thyroxine
31 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
32 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
33 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
34 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
35 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Recruiting NCT03298867 Phase 3
36 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
37 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
38 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
39 Early Levothyroxine Post Radioactive Iodine Active, not recruiting NCT01950260 Phase 2, Phase 3 Levothyroxine
40 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Not yet recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
41 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
42 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
43 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
44 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
45 LDL-Cholesterol Lowering Effect of KB2115 as Add on to Statin Completed NCT00593047 Phase 2 KB2115
46 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
47 Eprotirome for the Treatment of Dyslipidemia, Efficacy and Safety 12-Week, Phase ii Study to Assess the Safety and Efficacy of KB2115 in Patients With Primary Hypercholesterolemia Completed NCT00776321 Phase 2 Eprotirome;Placebo
48 LDL-Cholesterol Lowering Effect of KB2115 as Add on to Ezetimibe Completed NCT00677248 Phase 2 Ezetimibe and placebo;Eprotirome and ezetimibe
49 Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
50 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2 CFZ533

Search NIH Clinical Center for Hyperthyroidism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hyperthyroidism

Genetic Tests for Hyperthyroidism

Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism 29

Anatomical Context for Hyperthyroidism

MalaCards organs/tissues related to Hyperthyroidism:

39
Thyroid, Eye, Bone, Heart, Testes, Kidney, Pituitary

Publications for Hyperthyroidism

Articles related to Hyperthyroidism:

(show top 50) (show all 1189)
id Title Authors Year
1
Hyperthyroidism in Patients with Graves' Ophthalmopathy, and Thyroidal, Skeletal and Eye Muscle Specific Type 2 Deiodinase Enzyme Activities. ( 28750432 )
2017
2
A Case With Deteriorating Palmoplantar Pustulosis and Hyperthyroidism After Simultaneous Bimaxillary Orthognathic Surgery. ( 28858556 )
2017
3
Comparative Effectiveness of Treatment Choices for Graves' Hyperthyroidism - A Historical Cohort Study. ( 28049375 )
2017
4
Iron metabolism in patients with Graves' hyperthyroidism. ( 28833367 )
2017
5
Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report. ( 28658350 )
2017
6
Changes in Resting-State Cerebral Activity in Patients with Hyperthyroidism: A Short-Term Follow-Up Functional MR Imaging Study. ( 28878279 )
2017
7
Clinical efficacy of Yingliu mixture combined with metimazole for treating diffuse goitre with hyperthyroidism and its impact on related cytokines. ( 27927064 )
2017
8
Atrial fibrillation and hyperthyroidism: A literature review. ( 28822529 )
2017
9
Liquid formula improves compliance in cats with hyperthyroidism. ( 28733514 )
2017
10
Tremelimumab-Induced Graves Hyperthyroidism. ( 28785544 )
2017
11
Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidism. ( 28576880 )
2017
12
The effect of short-term treatment with lithium carbonate on the outcome of radioiodine therapy in patients with long-lasting Graves' hyperthyroidism. ( 28895066 )
2017
13
Novel germline mutation (Leu512Met) in the thyrotropin receptor gene (TSHR) leading to sporadic non-autoimmune hyperthyroidism. ( 28195550 )
2017
14
Struma Ovarii With Hyperthyroidism. ( 28394842 )
2017
15
Hyperthyroidism and the Heart. ( 28740583 )
2017
16
Dyschromatosis symmetrica hereditaria with cutaneous lupus erythematosus and hyperthyroidism. ( 28496371 )
2017
17
Effects of electromagnetic fields on bone loss in hyperthyroidism rat model. ( 27973686 )
2017
18
Hyperthyroidism and sick sinus syndrome, a rare but challenging association: A study of three cases. ( 28891553 )
2017
19
Myopathy in hyperthyroidism as a consequence of rapid reduction of thyroid hormone: A case report. ( 28746208 )
2017
20
Survival times for cats with hyperthyroidism treated with a 3.35 mCi iodine-131 dose: a retrospective study of 96 cases. ( 28699814 )
2017
21
Effects of Hyperthyroidism on Coronary Artery Disease: AA Computed Tomography Angiography Study. ( 28867263 )
2017
22
Takotsubo Myocardiopathy and Hyperthyroidism: A Case Report and Literature Review. ( 28781361 )
2017
23
Iodine concentration calculated by dual-energy computed tomography (DECT) as a functional parameter to evaluate thyroid metabolism in patients with hyperthyroidism. ( 28724406 )
2017
24
An FSH and TSH pituitary adenoma, presenting with precocious puberty and central hyperthyroidism. ( 28721217 )
2017
25
Recurrent Graves' hyperthyroidism after prolonged radioiodine-induced hypothyroidism. ( 28944001 )
2017
26
Subclinical Hyperthyroidism and the Cardiovascular Disease. ( 28915531 )
2017
27
Hypokalemic Paralysis Complicated by Concurrent Hyperthyroidism and Hyperaldosternoism: A Case Report. ( 28050008 )
2017
28
Prevalence of and risk factors for feline hyperthyroidism in South Africa. ( 28826266 )
2017
29
ST-segment elevation acute myocardial infarction associated with hyperthyroidism: beware of coronary spasm! ( 28858949 )
2017
30
Systemic lupus erythematosus and renal tubular acidosis associated with hyperthyroidism. Case Report. ( 27179580 )
2016
31
Serum Levels of Follistatin Are Positively Associated With Serum-Free Thyroxine Levels in Patients With Hyperthyroidism or Euthyroidism. ( 26844494 )
2016
32
Positive Correlation between Serum Osteocalcin and Testosterone in Male Hyperthyroidism Patients with High Bone Turnover. ( 27219888 )
2016
33
AN OVERVIEW OF ENDOGENOUS SUBCLINICAL HYPERTHYROIDISM AND CARDIAC DISEASE. ( 27631669 )
2016
34
Thymic hyperplasia and its spontaneous resolution with treatment of Graves' hyperthyroidism. ( 27190120 )
2016
35
The Natural History of Subclinical Hyperthyroidism in Graves' Disease: The Rule of Thirds. ( 27090092 )
2016
36
A caution regarding high-dose biotin therapy: misdiagnosis of hyperthyroidism in euthyroid patients. ( 27510354 )
2016
37
Low-dose spinal-epidural anesthesia for Cesarean section in a parturient with uncontrolled hyperthyroidism and thyrotoxic heart disease. ( 27216206 )
2016
38
Vasospastic myocardial infarction complicated with ventricular tachycardia in a patient with hyperthyroidism. ( 28043674 )
2016
39
Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study. ( 28009983 )
2016
40
Hyperdynamic Right Heart Function in Graves' Hyperthyroidism Measured by Echocardiography Normalises on Restoration of Euthyroidism. ( 28025026 )
2016
41
Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat. ( 27919641 )
2016
42
Misdiagnosis of Graves' Disease with Apparent Severe Hyperthyroidism in a Patient Taking Biotin Megadoses. ( 27043844 )
2016
43
Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism. ( 27193069 )
2016
44
Diagnosis and Management of Hyperthyroidism in Pregnancy: A Review. ( 27901552 )
2016
45
McCune Albright syndrome - association of fibrous dysplasia, cafAc-au-lait skin spots and hyperthyroidism - case report. ( 27857528 )
2016
46
Surgical Intervention for Medically Refractory Hyperthyroidism. ( 27171805 )
2016
47
A Case Report of Chorea Associated with Hyperthyroidism. ( 27042533 )
2016
48
Hyperthyroidism and Thyroid Carcinoma. ( 27930273 )
2016
49
Serum heart type fatty acid binding protein levels are not changed in hyperthyroidism. ( 26859315 )
2016
50
2016 AAFP Guidelines for the Management of Feline Hyperthyroidism. ( 27562983 )
2016

Variations for Hyperthyroidism

Expression for Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for Hyperthyroidism

Pathways related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 CGA GH1 GHRL GNAS LEP PRL
2
Show member pathways
12.6 CGA CTLA4 TG TPO TSHR
3
Show member pathways
12.25 CGA GH1 LEP PRL
4
Show member pathways
11.93 CGA GH1 GHRL LEP
5
Show member pathways
11.83 CGA GNAS SERPINA7 TG TPO TSHR
6 11.52 BGLAP CGA PRL
7 11.41 CGA GNAS TSHR
8 11.23 CGA GNAS TSHR
9 11.09 BGLAP CGA THRB
10 10.59 CGA TSHR
11 9.8 CGA TG TPO TRH TSHR

GO Terms for Hyperthyroidism

Cellular components related to Hyperthyroidism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 BGLAP GH1 GHRL LEP PRTN3 SERPINA6
2 extracellular region GO:0005576 9.47 BGLAP CGA GH1 GHRL GNAS LEP
3 endosome lumen GO:0031904 9.16 GH1 PRL

Biological processes related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.8 CGA SST TRH TSHR
2 female pregnancy GO:0007565 9.61 GNAS LEP PRL
3 energy reserve metabolic process GO:0006112 9.48 GNAS LEP
4 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.46 GH1 PRL
5 thyroid hormone generation GO:0006590 9.4 CGA TPO
6 hormone biosynthetic process GO:0042446 9.37 TG TPO
7 positive regulation of multicellular organism growth GO:0040018 9.33 GH1 GHRL TSHR
8 adult feeding behavior GO:0008343 9.32 GHRL LEP
9 response to nutrient levels GO:0031667 9.26 BGLAP LEP
10 hormone-mediated signaling pathway GO:0009755 9.13 GHRL TRH TSHR
11 positive regulation of JAK-STAT cascade GO:0046427 8.8 GH1 LEP PRL

Molecular functions related to Hyperthyroidism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 CGA GH1 GHRL LEP PRL SST
2 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Hyperthyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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