MCID: HYP076
MIFTS: 61

Hyperthyroidism malady

Summaries for Hyperthyroidism

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. if your thyroid is too active, it makes more thyroid hormones than your body needs. this is called hyperthyroidism. hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. grave's disease, an autoimmune disorder, is the most common cause. other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. the symptoms can vary from person to person. they may include being nervous or irritable mood swings fatigue or muscle weakness heat intolerance trouble sleeping hand tremors rapid and irregular heartbeat frequent bowel movements or diarrhea weight loss goiter, which is an enlarged thyroid that may cause the neck to look swollen to diagnose hyperthyroidism, your doctor will look at your symptoms, blood tests, and sometimes a thyroid scan. treatment is with medicines, radioiodine therapy, or thyroid surgery. no single treatment works for everyone. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hyperthyroidism, also known as overactive thyroid, is related to thyroiditis and graves' disease. An important gene associated with Hyperthyroidism is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Allograft rejection. The drugs sodium iodide and sodium iodide i123 and the compounds thyroxine and triiodothyronine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Disease Ontology:8 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia:63 Hyperthyroidism, often referred to as an overactive thyroid, is a condition in which the thyroid gland... more...

Aliases & Classifications for Hyperthyroidism

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

hyperthyroidism 8 22 10 44 33 60
overactive thyroid 8


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Disease Ontology8 DOID:7998
MeSH34 D006980
NCIt39 C3123

Related Diseases for Hyperthyroidism

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17GeneCards, 18GeneDecks
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Diseases in the Familial Hyperthyroidism Due to Mutations in Tsh Receptor family:

hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3TG, TPO, TSHR, SERPINA7, TRH, CGA
2graves' disease31.1TPO, TSHR, SERPINA7, SHBG, CGA, DIO2
3hypothyroidism31.0CGA, SHBG, TRH, SERPINA7, TSHR, TPO
4goiter30.9BGLAP, TG, TPO, TSHR, TSHB, SERPINA7
5thyrotoxicosis30.7TG, TPO, TSHR, SERPINA7, TRH
6adenoma30.7TG, TPO, TSHR, TSHB, TRH, TRHR
7nodular goiter30.6TSHR, TPO, TG
8autoimmune thyroiditis30.5TPO, TG
9subacute thyroiditis30.5TSHR, TPO, TG
10struma ovarii30.5TSHR, TG
11thyroid cancer30.5DIO2, TRH, TSHR, TPO, TG
12multinodular goiter30.5TSHR, TPO, TG
13hepatitis30.4SERPINA7, ALPP
14hyperparathyroidism30.4ALPP, ACP5, BGLAP
15myxedema30.4TSHR, TPO, TG
16primary hyperparathyroidism30.4BGLAP, ACP5, ALPP
17hypertension30.4RETN
18pituitary adenoma30.3CGA, GHRH, TRHR, TRH, SERPINA7, TSHB
19exophthalmos30.3TSHR, TRH
20diabetes mellitus30.2ALPP, RETN, SHBG, LSL, BGLAP
21follicular thyroid carcinoma30.2TSHR, TG
22obesity30.0DIO2, LSL, GHRH, SHBG, TRH, SERPINA6
23nontoxic goiter30.0BGLAP, TSHR, TPO, TG
24cholestasis30.0ALPP, SLCO1C1, CYP7A1
25neonatal thyrotoxicosis30.0TSHR
26leukemia30.0ACP5, TSHR, ALPP
27congenital hypothyroidism29.9SERPINA7, TSHB, TSHR, TPO, TG
28down syndrome29.9TPO, TSHR, CGA
29diabetes insipidus29.9TRH, GHRH
30pernicious anemia29.9TPO, TG
31panhypopituitarism29.9TSHB
32hypoparathyroidism29.9ALPP, BGLAP
33papillary carcinoma29.9TSHR, TPO, TG
34papillary thyroid carcinoma29.9TSHR, TPO, TG
35hypercalcemia29.9ALPP, BGLAP
36acromegaly29.6BGLAP, LSL, GHRH, SHBG, TRHR, TRH
37breast cancer29.6LPO, GHRH, SHBG, ACP5, SERPINA6, ALPP
38hypogonadism29.6BGLAP, LSL, CGA, SHBG, TRH
39cushing's syndrome29.6BGLAP, LSL, GHRH, TRH, RETN
40hyperthyroxinemia29.6TPO, TSHR, SERPINA7, TRH
41osteoporosis29.6BGLAP, LSL, SHBG, ACP5, ALPP
42liver cirrhosis29.6LSL, GHRH, RETN, SERPINA7, ALPP
43hypopituitarism29.6CGA, GHRH, SHBG, TRH
44anorexia nervosa29.6LSL, GHRH, SHBG, RETN
45endemic goiter29.6TSHR, TPO, TG
46pituitary tumors29.6TSHB, TRH, TRHR, GHRH
47hyperglycemia29.6TPO, RETN, GHRH, LSL
48hyperandrogenism29.6LSL, CGA, SHBG, RETN
49plummer's disease29.6SHBG, TPO, TG
50amenorrhea29.6TRH, SHBG

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to hyperthyroidism

Clinical Features for Hyperthyroidism

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Drugs & Therapeutics for Hyperthyroidism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperthyroidism

Drug clinical trials:

Search ClinicalTrials for Hyperthyroidism

Search NIH Clinical Center for Hyperthyroidism

Search CenterWatch for Hyperthyroidism

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperthyroidism

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22GTR
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Genetic tests related to Hyperthyroidism:

id Genetic test Affiliating Genes
1 Hyperthyroidism22

Anatomical Context for Hyperthyroidism

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32MalaCards
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MalaCards organs/tissues related to Hyperthyroidism:

32
Thyroid, Bone, Testes, Heart, Kidney, Pituitary, Brain, Liver, Endothelial, Skeletal muscle, Breast, T cells, Eye, Thymus, Adrenal gland, Bone marrow, Smooth muscle, Colon, B cells, Myeloid, Testis, Adipocyte, Lung, Spinal cord, Skin, Fetal brain

Animal Models for Hyperthyroidism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperthyroidism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.0TRH, TRHR, GHRH, CGA, CYP7A1, SLCO1C1
2MP:000537610.7TG, DIO2, CGA, GHRH, TRHR, TRH

Publications for Hyperthyroidism

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Sources:
50PubMed
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Articles related to Hyperthyroidism:

(show top 50)    (show all 1016)
idTitleAuthorsYear
1
A large cohort study of hypothyroidism and hyperthyroidism in relation to gynecologic cancers. (23956749)
2013
2
COMPARISON BETWEEN COMPUTED TOMOGRAPHY AND (99m) TC- PERTECHNETATE SCINTIGRAPHY CHARACTERISTICS OF THE THYROID GLAND IN CATS WITH HYPERTHYROIDISM. (24033856)
2013
3
Relapse of hyperthyroidism after hemithyroidectomy in concurrent medullary thyroid cancer and Graves' disease. (24020714)
2013
4
Generalized chorea with abnormal 18F-fluorodeoxyglucose positron emission tomography findings in a patient with hyperthyroidism. (22831908)
2013
5
Evaluation of Oxidative Status with Exhaled Breath 8-isoprostane Levels in Patients with Hyperthyroidism. (24107071)
2013
6
Hyperthyroidism in dogs caused by consumption of thyroid-containing head meat. (23385074)
2013
7
Hyperthyroidism in cats: what's causing this epidemic of thyroid disease and can we prevent it? (23087006)
2012
8
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. (22529182)
2012
9
Decabromobiphenyl, polybrominated diphenyl ethers, and brominated phenolic compounds in serum of cats diagnosed with the endocrine disease feline hyperthyroidism. (22311549)
2012
10
Successful treatment of thyrotoxic crisis after esophagectomy in an elderly woman with hyperthyroidism. (22632530)
2012
11
Hyperthyroidism and thyroid autoimmunity induced by sorafenib in metastatic renal cell cancer. (22562706)
2012
12
A Japanese family with familial nonautoimmune hyperthyroidism with a novel mutation (Asn406Ser) in extracellular domain of thyrotrophin receptor. (22175420)
2012
13
Ultrasonographic measurements of adrenal glands in cats with hyperthyroidism. (22122403)
2012
14
Transient hyperthyroidism after surgery for secondary hyperparathyroidism: a common problem. (21813380)
2011
15
Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient. (21823045)
2011
16
Commentary on: hypocalcemia following treatment for hyperthyroidism. (21622924)
2011
17
Persistent high TRAb values during pregnancy predict increased risk of neonatal hyperthyroidism following radioiodine therapy for refractory hyperthyroidism. (20962435)
2011
18
Outcome of very long-term treatment with antithyroid drugs in Graves' hyperthyroidism associated with Graves' orbitopathy. (21190446)
2011
19
Hyperthyroidism. (21786493)
2011
20
The American Thyroid Association and American Association of Clinical Endocrinologists guidelines for hyperthyroidism and other causes of thyrotoxicosis: an appraisal. (21700559)
2011
21
Hyperthyroidism: a stepwise approach to management. (21731916)
2011
22
Embolic risk in atrial fibrillation that arises from hyperthyroidism: review of the medical literature. (21720457)
2011
23
Cardiovascular involvement in patients with different causes of hyperthyroidism. (20585347)
2010
24
Fat and energy economy in hypo- and hyperthyroidism are not the mirror image of one another. (20028877)
2010
25
Hyperthyroidism caused by a germline activating mutation of the thyrotropin receptor gene: difficulties in diagnosis and therapy. (20146656)
2010
26
Confluent andA reticulated papillomatosis associated withA hyperthyroidism. (20937587)
2010
27
Medical treatment of hyperthyroidism: state of the art. (20496313)
2010
28
Vasopressinergic network abnormalities potentiate conditioned anxious state of rats subjected to maternal hyperthyroidism. (20371268)
2010
29
Hyperthyroidism with fibrous dysplasia: an unusual presentation of McCune-Albright syndrome. (17516298)
2007
30
Changes in expression of T-helper (Th) 1- and Th2-associated chemokine receptors on peripheral blood lymphocytes and plasma concentrations of their ligands, interferon-inducible protein-10 and thymus and activation-regulated chemokine, after antithyroid drug administration in hyperthyroid patients with Graves' disease. (17535861)
2007
31
A novel activating mutation in transmembrane helix 6 of the thyrotropin receptor as cause of hereditary nonautoimmune hyperthyroidism. (16756474)
2006
32
Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition. (16061827)
2005
33
Central congenital hypothyroidism due to gestational hyperthyroidism: detection where prevention failed. (14671180)
2003
34
Serum concentrations of tumour necrosis factor-alpha (TNF-alpha) and soluble TNF-alpha receptor p55 in patients with hypothyroidism and hyperthyroidism before and after normalization of thyroid function. (12354134)
2002
35
Autoimmune hyperthyroidism in two adolescents with DiGeorge/velocardiofacial syndrome (22q11 deletion). (12014397)
2002
36
Current treatment of nodular goiter with hyperthyroidism (Plummer's disease): surgery versus radioiodine. (12490836)
2002
37
Methylprednisolone increases plasma leptin levels in Graves' hyperthyroidism patients with active Graves' ophthalmopathy. (10965934)
2000
38
An elevation of stem cell factor in patients with hyperthyroid Graves' disease. (9669287)
1998
39
Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans. (9178027)
1997
40
Constitutively active germline mutation of the thyrotropin receptor gene as a cause of congenital hyperthyroidism. (9427897)
1997
41
Elevated plasma adrenomedullin level in hyperthyroidism. (8817157)
1996
42
Age-related therapeutic response to antithyroid drug in patients with hyperthyroid Graves' disease. (8176146)
1994
43
Elderly patients with suppressed serum TSH but normal free thyroid hormone levels usually have mild thyroid overactivity and are at increased risk of developing overt hyperthyroidism. (1670067)
1991
44
The lack of nocturnal serum thyrotropin surge in patients with nontoxic nodular goiter may predict the subsequent occurrence of hyperthyroidism. (1874936)
1991
45
"Lupus anticoagulant" in immune hyperthyroidism]. (2120025)
1990
46
The clinical and thyroid function studies of lymphocytic thyroiditis with spontaneously resolving hyperthyroidism: comparison to subacute thyroiditis. (15759376)
1986
47
Acute intermittent porphyria and hydatid mole: etiology of hyperthyroidism. (6720802)
1984
48
Muscle pathology in hypokalemic periodic paralysis with hyperthyroidism. I. High resolution light microscopic study of a case. (5439132)
1970
49
Acute myelomonocytic leukemia after radioiodne therapy of hyperthyroidism. (14452055)
1962
50
RESULTS OF THYROIDECTOMY IN HYPERTHYROIDISM ASSOCIATED WITH NEUROCIRCULATORY ASTHENIA. (17857356)
1939

Genetic Variations for Hyperthyroidism

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Expression for genes affiliated with Hyperthyroidism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for genes affiliated with Hyperthyroidism

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Hyperthyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8CGA, GHRH, TRHR, TRH, TSHB, TSHR
2
Hide members
10.7TG, TPO, TSHR, TSHB
3
Hide members
10.6TSHR, TSHB, CGA
4
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10.6TSHR, TSHB
5
Hide members
10.6TG, TPO

Compounds for genes affiliated with Hyperthyroidism

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 49PharmGKB
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Compounds related to Hyperthyroidism according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1thyroxine44 2412.7BGLAP, LSL, DIO2, LPO, CGA, GHRH
2triiodothyronine4411.5TG, TPO, TSHR, LSL, DIO2, CGA
3estradiol44 11 2413.5SLCO1C1, RETN, TRH, SHBG, GHRH, CGA
4arginine4411.5SERPINA7, SERPINA6, TSHR, TG, TPO, SHBG
5aspartate4411.5TG, TPO, ALPP, TSHR, SHBG, GHRH
6testosterone44 59 11 2414.4SERPINA6, TPO, SERPINA7, RETN, TRH, SHBG
7alanine4411.4SHBG, CGA, TRHR, RETN, SERPINA7, SERPINA6
8lipid4411.4SERPINA6, CYP7A1, GHRH, SERPINA7, ACP5, RETN
9methimazole44 2 1113.4TG, LSL, DIO2, LPO, TRH, SERPINA7
10glucose4411.3TSHR, SERPINA6, SERPINA7, RETN, LSL, CYP7A1
11progesterone44 59 28 11 2415.3SERPINA6, SERPINA7, TSHR, RETN, GHRH, TRH
12creatinine4411.3RETN, ACP5, TPO, TG, ALPP, SERPINA7
13ribonucleic acid4411.3SERPINA7, TG, TPO, TSHR, TSHB, SERPINA6
14cholesterol44 28 11 2414.3TPO, TSHR, SERPINA6, SERPINA7, RETN, CYP7A1
15acth4411.3GHRH, LSL, TRH, SERPINA7, TSHR, TPO
16dexamethasone44 49 28 1114.3BGLAP, DIO2, GHRH, SHBG, TRH, CYP7A1
17hydrocortisone44 2 59 1114.3LSL, SHBG, SERPINA6, ALPP, TG, TPO
18estrogen4411.2TRH, DIO2, CYP7A1, TSHR, TG, SERPINA7
19calcium44 49 11 2414.2ALPP, BGLAP, RETN, ACP5, TSHR, TPO
20steroid4411.2TPO, LSL, CGA, GHRH, SHBG, CYP7A1
21tamoxifen44 49 28 1114.2LSL, ALPP, SERPINA6, SERPINA7, CGA, SHBG
22iodine44 2412.2TPO, TG, TSHR, SERPINA7, TRH, DIO2
23prednisolone44 28 1113.2TSHR, SERPINA6, TG, BGLAP, LSL, SHBG
24cysteine4411.2TG, TPO, TSHR, SERPINA6, ACP5, RETN
25125i4411.2TPO, TSHR, SERPINA7, TG, LPO, DIO2
26sialic acid4411.2TG, TSHR, SERPINA6, CGA, LPO, LSL
27iodide44 2412.2SERPINA7, TSHR, DIO2, TPO, LPO, TG
28adenylate4411.1TG, TPO, TSHR, SERPINA6, TRH, SHBG
29carbimazole44 1112.1SHBG, BGLAP, TPO, SERPINA6, TSHR
30ascorbic acid44 2412.1ALPP, BGLAP, TPO, LPO, CGA, TG
31norepinephrine44 11 2413.1TRH, ALPP, RETN, CGA, GHRH
32retinoic acid44 2412.1TG, TSHB, TPO, ALPP, TSHR, CYP7A1
33cycloheximide4411.1DIO2, TRHR, TRH, ALPP, GHRH
34phenytoin44 49 28 1114.0SHBG, SLCO1C1, SERPINA7, CGA, ALPP
35sodium iodide4411.0LPO, TSHR, TG, TPO
36propylthiouracil44 2 1113.0TG, DIO2
37Liothyronine11 2412.0SERPINA7, TPO, DIO2, SLCO1C1
38gnrh4411.0LSL, CGA, GHRH, SHBG, TRH, BGLAP
39deoxypyridinoline4411.0LSL, BGLAP, ACP5
40tibolone4410.9SHBG, LSL, BGLAP, ACP5
41diiodotyrosine4410.9LPO, TG, TPO
42forskolin44 49 1112.9GHRH, RETN, TSHR
43estrone44 28 11 2413.8SERPINA7, LSL, SHBG, SERPINA6, BGLAP
4417-hydroxyprogesterone44 2411.8SHBG, CGA, RETN, SERPINA6
4525-hydroxyvitamin d4410.8ACP5, SHBG, BGLAP, ALPP
46urea44 11 2412.8SERPINA7, RETN, TRH, GHRH, LSL
47vitamin d4410.7BGLAP, ACP5, SHBG, ALPP, CGA, GHRH
48glutamate4410.7ALPP, TG, GHRH, CGA, TSHR, RETN
49carbohydrates4410.7TSHR, TG, SERPINA6, LSL, SHBG
50bromocriptine28 44 1112.4GHRH, CGA, SHBG, TRH

GO Terms for genes affiliated with Hyperthyroidism

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16Gene Ontology
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Cellular components related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8LPO, GHRH, RETN, SERPINA7, SERPINA6, TG
2extracellular regionGO:00557610.6TG, BGLAP, CGA, GHRH, SHBG, TRH

Biological processes related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.7TG, TPO, CGA, DIO2
2response to vitamin AGO:03318910.6TSHB, SERPINA7
3hormone biosynthetic processGO:04244610.5TG, TPO, DIO2
4cell-cell signalingGO:00726710.4CGA, GHRH, TRH, TSHB, TSHR

Molecular functions related to Hyperthyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7TG, TSHB, RETN, CGA

Products for genes affiliated with Hyperthyroidism

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  • Antibodies
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  • Antibodies

Sources for Hyperthyroidism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet