MCID: HYP029
MIFTS: 27

Hyperthyroxinemia

Categories: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

MalaCards integrated aliases for Hyperthyroxinemia:

Name: Hyperthyroxinemia 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2855
MeSH 41 D006981
UMLS 69 C0020551

Summaries for Hyperthyroxinemia

MalaCards based summary : Hyperthyroxinemia is related to thyroid hormone resistance, generalized, autosomal dominant and congenital hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include thyroid, pituitary and testes.

Wikipedia : 72 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

Related Diseases for Hyperthyroxinemia

Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 thyroid hormone resistance, generalized, autosomal dominant 31.9 SERPINA7 TRH
2 congenital hypothyroidism 29.7 TPO TSHR
3 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.6 TPO TSHR
4 multinodular goiter 29.5 TPO TSHR
5 hashimoto thyroiditis 29.3 TPO TSHR
6 thyroiditis 29.1 SERPINA7 TPO TRH TSHR
7 graves' disease 29.1 SERPINA7 TPO TSHR
8 hypothyroidism 28.7 SERPINA7 TPO TRH TSHR
9 graves disease 1 28.6 SERPINA7 TPO TRH TSHR
10 goiter 28.2 SERPINA7 TPO TRH TSHR
11 hyperthyroidism 28.2 SERPINA7 TPO TRH TSHR
12 hyperthyroxinemia, familial dysalbuminemic 12.5
13 hyperthyroxinemia, dystransthyretinemic 12.4
14 thyroid hormone plasma membrane transport defect 11.1
15 paramyloidosis 10.3 ALB TTR
16 burns 10.2 ALB TTR
17 marasmus 10.2 ALB TTR
18 kwashiorkor 10.2 ALB TTR
19 decubitus ulcer 10.2 ALB TTR
20 aleutian mink disease 10.2 ALB TTR
21 chronic ulcer of skin 10.2 ALB TTR
22 autonomic nervous system disease 10.2 ALB TTR
23 analbuminemia 10.2 ALB TTR
24 dysentery 10.2 ALB TTR
25 euthyroid sick syndrome 10.2 ALB SERPINA7
26 protein-energy malnutrition 10.2 ALB TTR
27 demyelinating polyneuropathy 10.2 ALB TTR
28 testicular yolk sac tumor 10.2 ALB TTR
29 obstructive jaundice 10.2 ALB TTR
30 nutritional deficiency disease 10.1 ALB TTR
31 hypothyroidism, congenital, nongoitrous, 2 10.1 SERPINA7 TSHR
32 acquired metabolic disease 10.1 ALB TTR
33 respiratory failure 10.1 ALB TTR
34 neonatal hypothyroidism 10.0 TPO TSHR
35 immune system disease 10.0 ALB TSHR
36 myxedema 10.0 TPO TSHR
37 nodular goiter 10.0 TPO TSHR
38 hepatocellular carcinoma 10.0
39 follicular adenoma 10.0 TPO TSHR
40 nervous system disease 9.9 ALB TTR
41 papillary carcinoma 9.9 TPO TSHR
42 differentiated thyroid carcinoma 9.9 TPO TSHR
43 thyroid hormone resistance, generalized, autosomal recessive 9.9
44 chronic kidney failure 9.9 ALB TTR
45 chromophobe adenoma 9.9 SERPINA7 TRH
46 thyroid cancer, nonmedullary, 2 9.8 TPO TSHR
47 hypersensitivity reaction disease 9.7 ALB TPO TSHR
48 hypercholesterolemia, familial 9.7
49 pheochromocytoma 9.7
50 myeloma, multiple 9.7

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to Hyperthyroxinemia

Symptoms & Phenotypes for Hyperthyroxinemia

Drugs & Therapeutics for Hyperthyroxinemia

Search Clinical Trials , NIH Clinical Center for Hyperthyroxinemia

Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

Anatomical Context for Hyperthyroxinemia

MalaCards organs/tissues related to Hyperthyroxinemia:

38
Thyroid, Pituitary, Testes

Publications for Hyperthyroxinemia

Articles related to Hyperthyroxinemia:

(show top 50) (show all 133)
# Title Authors Year
1
Hyperthyroxinemia is positively associated with prevalent and incident type 2 diabetes mellitus in two population-based samples from Northeast Germany and Denmark. ( 29239740 )
2018
2
Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia. ( 29163366 )
2017
3
First Report of Familial Dysalbuminemic Hyperthyroxinemia With an ALB Variant. ( 27834068 )
2017
4
Familial Dysalbuminemic Hyperthyroxinemia that was Inappropriately Treated with Thiamazole Due to Pseudo-thyrotoxic Symptoms. ( 28781323 )
2017
5
SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE. ( 28816534 )
2017
6
A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH). ( 27904073 )
2016
7
Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia. ( 26777880 )
2016
8
Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Man Caused by a Point Albumin Gene Mutation (R218P). ( 27081329 )
2016
9
Lithium-induced transient euthyroid hyperthyroxinemia: a case report. ( 25133055 )
2014
10
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. ( 24494774 )
2014
11
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. ( 25153218 )
2014
12
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. ( 24646103 )
2014
13
Anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia and suspected impairment of T4 to T3 conversion: a case report. ( 25237453 )
2014
14
[Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. ( 22781450 )
2012
15
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. ( 21149501 )
2011
16
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. ( 19282355 )
2009
17
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. ( 18724828 )
2008
18
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. ( 17190692 )
2006
19
Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. ( 15833783 )
2005
20
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. ( 15068631 )
2004
21
[The specific features of thyrotoxicosis and euthyroid hyperthyroxinemia developed due to the use of cordarone]. ( 15732718 )
2004
22
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. ( 12743361 )
2003
23
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. ( 12099390 )
2002
24
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. ( 11743520 )
2001
25
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. ( 11385707 )
2001
26
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. ( 10946882 )
2000
27
[Hyperthyroxinemia and clinical euthyroidism. Report of one case]. ( 10436700 )
1999
28
A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? ( 10999134 )
1999
29
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. ( 10430791 )
1999
30
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. ( 10526251 )
1999
31
Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. ( 10352382 )
1999
32
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. ( 9329347 )
1997
33
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( 8784093 )
1996
34
Etiology and outcome of non-estrogen associated hyperthyroxinemia in euthyroid patients at the San Juan City Hospital. ( 8885441 )
1996
35
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. ( 8964572 )
1996
36
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. ( 8929830 )
1996
37
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. ( 8702585 )
1996
38
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. ( 7829599 )
1995
39
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. ( 7852505 )
1995
40
Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report. ( 8648063 )
1995
41
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. ( 7628382 )
1995
42
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. ( 15251607 )
1995
43
Familial dysalbuminemic hyperthyroxinemia in pregnancy. ( 8548059 )
1995
44
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. ( 8288714 )
1994
45
Hyperthyroxinemia after surgery for primary hyperparathyroidism. ( 8052060 )
1994
46
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. ( 7937417 )
1994
47
[Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. ( 8196175 )
1994
48
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. ( 7742472 )
1994
49
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. ( 8048949 )
1994
50
Effect of short-term hyperthyroxinemia on vitamin D metabolism in congenital hypothyroidism. ( 8406326 )
1993

Variations for Hyperthyroxinemia

Expression for Hyperthyroxinemia

Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for Hyperthyroxinemia

Pathways related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 ALB SERPINA7 TPO TSHR TTR
2 10.8 ALB TTR
3 9.58 TPO TRH TSHR

GO Terms for Hyperthyroxinemia

Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ALB SERPINA7 TPO TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.16 ALB TPO
2 hormone-mediated signaling pathway GO:0009755 8.96 TRH TSHR
3 thyroid hormone transport GO:0070327 8.62 SERPINA7 TTR

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TRH TTR

Sources for Hyperthyroxinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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