MCID: HYP029
MIFTS: 42

Hyperthyroxinemia malady

Summaries for Hyperthyroxinemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards: Hyperthyroxinemia is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (transthyretin), and among its related pathways are Phenylalanine metabolism and Class A/1 (Rhodopsin-like receptors). The compounds idpn and t4 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Hyperthyroxinemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

hyperthyroxinemia 8 10 44 60


External Ids:

Disease Ontology8 DOID:2855
MeSH34 D006981

Related Diseases for Hyperthyroxinemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.7TRH, CD79A, SERPINA7, TSHR, TPO
2hypothyroidism30.2TPO, TSHR, TRH
3hepatocellular carcinoma30.2THRB, OXA1L, SERPINA7, ALB
4thyrotoxicosis30.2THRB, TRH, TPO, TSHR, SERPINA7
5congenital hypothyroidism30.0SERPINA7, TPO, TSHR
6thyroid hormone resistance syndrome30.0SERPINA7, TRH, THRB
7pancreatitis29.8ALB
8hepatitis29.8SERPINA7, TTR
9conjunctivitis29.8CD79A
10multinodular goiter29.8TPO, TSHR
11autoimmune thyroiditis29.8TSHR, TPO, SERPINA7
12myeloma29.8ALB, CD79A, OXA1L
13pituitary adenoma29.8TRH, SERPINA7, PRL
14graves' disease29.8SERPINA7, THRB, TSHR, TPO
15goiter29.8TRH, THRB, TPO, TSHR, SERPINA7
16adenoma29.8PRL, TRH, THRB, TSHR, TPO
17hyperthyroidism29.8TPO, TSHR, SERPINA7, THRB, TRH, PRL
18dysalbuminemic hyperthyroxinemia10.2
19hyperthyroxinemia dystransthyretinemic euthyroidal10.2
20acquired immunodeficiency syndrome10.0ALB
21arthritis10.0ALB
22lung cancer10.0ALB
23addison's disease10.0TPO
24hepatitis c10.0ALB
25peritonitis10.0ALB
26endogenous depression10.0TRH
27neonatal thyrotoxicosis10.0TSHR
28lymphatic system disease10.0ALB
29melancholia10.0TRH
30protein-energy malnutrition10.0TTR, ALB
31prion disease10.0CD79A
32alzheimer's disease10.0TTR, OXA1L
33poems syndrome10.0CD79A
34proliferative glomerulonephritis10.0CD79A
35nutritional deficiency disease10.0ALB, TTR
36coronary heart disease10.0OXA1L
37protein-losing enteropathy10.0ALB, OXA1L
38endemic goiter10.0TPO, TSHR
39nontoxic goiter10.0TSHR, TPO
40measles10.0CD79A
41myxedema10.0TPO, TSHR
42insulin resistance10.0ALB, TTR
43myocardial infarction10.0TPO, OXA1L
44lupus erythematosus10.0CD79A
45down syndrome10.0TSHR, TPO
46growth hormone deficiency10.0PRL
47euthyroid sick syndrome10.0TRH, SERPINA7
48gastroenteritis10.0CD79A
49subacute thyroiditis10.0TSHR, TPO
50diphtheria10.0CD79A

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Clinical Features for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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32MalaCards
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MalaCards organs/tissues related to Hyperthyroxinemia:

32
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperthyroxinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2TSHR
2MP:00053766.7TPO, PRL, TRH, CD79A, TTR, THRB

Publications for Hyperthyroxinemia

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50PubMed
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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. (22781450)
2012
2
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
3
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. (19282355)
2009
4
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. (12099390)
2002
5
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
6
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. (10526251)
1999
7
A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? (10999134)
1999
8
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
9
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. (8929830)
1996
10
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. (8964572)
1996
11
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. (8784093)
1996
12
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. (8702585)
1996
13
Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report. (8648063)
1995
14
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
15
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
16
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. (8288714)
1994
17
Hyperthyroxinemia after surgery for primary hyperparathyroidism. (8052060)
1994
18
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
19
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
20
Effect of short-term hyperthyroxinemia on vitamin D metabolism in congenital hypothyroidism. (8406326)
1993
21
Free thyroxine measured by the Ciba Corning ACS-180 on samples from patients with familial dysalbuminemic hyperthyroxinemia. (8353971)
1993
22
X-ray crystal structure of the Ala-109-->Thr variant of human transthyretin which produces euthyroid hyperthyroxinemia. (8428916)
1993
23
Fluorescence investigations of albumin from patients with familial dysalbuminemic hyperthyroxinemia. (8475173)
1993
24
Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report. (1769174)
1991
25
Pheochromocytoma in a patient with hyperthyroxinemia. (1986587)
1991
26
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
27
Transient prealbumin-associated hyperthyroxinemia in TSH-producing pituitary adenoma. (2108434)
1990
28
Diagnosis of familial dysalbuminemic hyperthyroxinemia and investigation of the nature of the variant albumin. (2135643)
1990
29
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
30
Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. (2493680)
1989
31
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
32
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
33
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
34
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
35
Coexistence of familial dysalbuminemic hyperthyroxinemia with familial hypercholesterolemia and multiple lipoprotein type hyperlipidemia. (3407659)
1988
36
Euthyroid hyperthyroxinemia: a case report. (3431505)
1987
37
Euthyroid hyperthyroxinemia and inappropriate secretion of thyrotropin. Recognition and diagnosis. (3111399)
1987
38
Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. (3112186)
1987
39
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
40
Familial euthyroid hyperthyroxinemia secondary to pituitary and peripheral resistance to thyroid hormones. (2981377)
1985
41
The diagnostic challenge of euthyroid hyperthyroxinemia. (3927889)
1985
42
Case report: familial dysalbuminemic hyperthyroxinemia--a variant. (6590861)
1984
43
Euthyroid hyperthyroxinemia. (6368663)
1983
44
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin. (6412142)
1983
45
Hyperthyroxinemia in patients with acute psychiatric disorders. (6638040)
1983
46
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
47
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
48
Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. (7287882)
1981
49
Hyperthyroxinemia and hypotriiodothyroninemia with clinical euthyroidism. (7246597)
1981
50
Euthyroid, familial hyperthyroxinemia. (7366688)
1980

Genetic Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperthyroxinemia

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Pathways for genes affiliated with Hyperthyroxinemia

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29KEGG, 53Reactome
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Pathways related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TPO, ADH5
2
Hide members
8.4TSHR, THRA, THRB, TRH, PRL

Compounds for genes affiliated with Hyperthyroxinemia

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Hyperthyroxinemia according to GeneCards/GeneDecks:

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idCompoundScoreTop Affiliating Genes
1idpn4410.2TTR, ALB
2t42810.0THRA, THRB
3reverse triiodothyronine2810.0THRB, THRA
43,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid1110.0THRB, THRA
53,3,5-triiodothyroacetic acid2810.0THRA, THRB
6kb-141289.9THRB, THRA
7sodium octanoate449.9ALB, OXA1L
8azapropazone44 1110.8OXA1L, ALB
9Dextrothyroxine119.8THRA, THRB, TPO
10tolmetin glucuronide449.8OXA1L, ALB
11amiodarone44 49 28 1112.8THRB, TPO, SERPINA7
12dansylsarcosine449.8OXA1L, ALB
13rhsa449.7ALB, OXA1L
14nh-3289.7THRB, THRA
15pirprofen449.7ALB, OXA1L
16flurbiprofen44 28 49 1112.7ALB, TTR, OXA1L
17gc-1289.7THRB, THRA
18vitamin d449.7THRA, THRB, CD79A
19125i449.6SERPINA7, TSHR, TPO
20piroxicam44 1110.6ALB, CD79A, OXA1L
21t3289.6THRB, THRA
22iodine44 2410.5TSHR, SERPINA7, TRH, TPO
23l-tryptophan44 28 11 2412.5OXA1L, ALB, PRL
24diflunisal44 1110.5TTR, SERPINA7, ALB, OXA1L
25urea44 11 2411.5TRH, TTR, ALB, SERPINA7
26methimazole44 2 1111.5TRH, TPO, TSHR, SERPINA7
27salicylic acid44 2810.5ALB, SERPINA7, TTR, OXA1L
28phenytoin44 49 28 1112.4SERPINA7, CD79A, OXA1L, ALB
29Levothyroxine119.4THRA, THRB, SERPINA7, TTR, ALB
30Liotrix119.4SERPINA7, THRB, TTR, THRA, ALB
31kebuzone449.3OXA1L, ALB
32ribonucleic acid449.1PRL, THRB, TPO, TSHR, SERPINA7
33acth449.1TRH, SERPINA7, TPO, TSHR, PRL
34Liothyronine11 2410.1TPO, ALB, THRA, THRB, TTR, SERPINA7
35fibrinogen449.1OXA1L, ALB, TPO, CD79A, TTR
36cholesterol44 28 11 2412.0TTR, TPO, TSHR, ALB, SERPINA7, THRB
37polyethylene glycol448.9PRL, OXA1L, CD79A, TSHR, ALB
38glutaraldehyde448.9CD79A, ALB, OXA1L, TTR, TRH
39sodium dodecylsulfate448.9SERPINA7, TTR, ALB, TPO, OXA1L, CD79A
40estradiol44 11 2410.8PRL, TRH, THRA, TSHR, ALB, SERPINA7
41alanine448.7ADH5, CD79A, TTR, THRB, SERPINA7, ALB
42cysteine448.6TPO, ALB, TSHR, THRB, OXA1L, CD79A
43progesterone44 59 28 11 2412.5TSHR, THRA, THRB, SERPINA7, PRL, TRH
44retinoic acid44 249.5THRA, ADH5, TSHR, TPO, TTR, CD79A
45triiodothyronine448.1TRH, PRL, TTR, THRB, THRA, SERPINA7
46testosterone44 59 11 2411.1ALB, THRB, PRL, TRH, CD79A, TTR
47glucose448.1TSHR, SERPINA7, PRL, TTR, TRH, ALB
48estrogen448.0PRL, TSHR, TRH, SERPINA7, CD79A, TTR
49arginine447.7SERPINA7, PRL, THRB, TRH, CD79A, ADH5
50thyroxine44 247.8PRL, THRA, THRB, TTR, CD79A, OXA1L

GO Terms for genes affiliated with Hyperthyroxinemia

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16Gene Ontology
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Biological processes related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosterone stimulusGO:0514129.7SERPINA7, TRH
2female courtship behaviorGO:0080509.6THRA, THRB
3hormone-mediated signaling pathwayGO:0097559.3THRA, TRH

Molecular functions related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:0425629.9TTR, SERPINA7
2thyroid hormone bindingGO:0703249.7THRA, THRB
3thyroid hormone receptor activityGO:0048879.7THRA, THRB
4chromatin DNA bindingGO:0314909.7THRA, THRB
5fatty acid bindingGO:0055049.6ADH5, ALB

Products for genes affiliated with Hyperthyroxinemia

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Sources for Hyperthyroxinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet