MCID: HYP029
MIFTS: 26

Hyperthyroxinemia malady

Categories: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

Aliases & Descriptions for Hyperthyroxinemia:

Name: Hyperthyroxinemia 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2855
MeSH 42 D006981
UMLS 69 C0020551

Summaries for Hyperthyroxinemia

MalaCards based summary : Hyperthyroxinemia is related to hyperthyroxinemia, dystransthyretinemic and hyperthyroxinemia, familial dysalbuminemic. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways/superpathways are Insulin secretion and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include thyroid, pituitary and testes.

Wikipedia : 71 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

Related Diseases for Hyperthyroxinemia

Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 hyperthyroxinemia, dystransthyretinemic 12.2
2 hyperthyroxinemia, familial dysalbuminemic 12.2
3 dysalbuminemic hyperthyroxinemia 12.0
4 thyroid hormone plasma membrane transport defect 10.8
5 thyroiditis 10.3
6 phaeochromocytoma 10.2 ALB TTR
7 male genital organ stricture 10.2 ALB TTR
8 female infertility of uterine origin 10.2 ALB TTR
9 inner ear disease 10.2 ALB TTR
10 cataract 10.2 ALB TTR
11 erythema infectiosum 10.1 ALB TTR
12 peripheral vascular disease 10.1 ALB TTR
13 hemopericardium 10.1 ALB TTR
14 spastic entropion 10.1 ALB TTR
15 glucosephosphate dehydrogenase deficiency 10.1 ALB SERPINA7
16 bladder sarcoma 10.1 ALB TTR
17 aortic valve prolapse 10.1 ALB TTR
18 krauss herman holmes syndrome 10.1 ALB OXA1L
19 focal epithelial hyperplasia 10.1 ALB TTR
20 paranasal sinus sarcoma 10.1 ALB TTR
21 central nervous system leiomyoma 10.1 ALB TTR
22 thyroid hormone resistance, autosomal recessive 10.1 SERPINA7 TRH
23 uterine ligament serous adenocarcinoma 10.1 ALB TTR
24 diencephalic neoplasm 10.0 SERPINA7 TRH
25 anogenital venereal wart 10.0 ALB TTR
26 body dysmorphic disorder 10.0 ALB TTR
27 chronic myocardial ischemia 10.0 ALB TTR
28 background diabetic retinopathy 10.0 SERPINA7 TPO
29 krabbe disease 10.0 SERPINA7 TPO
30 endemic goiter 10.0 SERPINA7 TPO
31 mixed eosinophil-basophil adenoma 10.0 SERPINA7 TPO
32 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 9.9 ALB OXA1L TTR
33 janus kinase-3 deficiency 9.9 SERPINA7 TPO
34 hypothyroidism 9.9
35 hepatocellular carcinoma 9.9
36 thyroid hormone resistance 9.9
37 extrahepatic bile duct adenocarcinoma 9.9 SERPINA7 TPO
38 congenital hypothyroidism 9.8
39 hypothyroidism, congenital, nongoitrous, 1 9.8 SERPINA7 TPO TRH
40 broad ligament malignant neoplasm 9.8 SERPINA7 TPO TRH
41 aflatoxins-related hepatocellular carcinoma 9.8 SERPINA7 TPO TRH
42 autoimmune hemolytic anemia 9.8 SERPINA7 TPO TRH
43 otosclerosis 9.8 SERPINA7 TPO TRH
44 glomangiomyoma 9.8 SERPINA7 TPO TRH
45 cholesterol embolism 9.8 SERPINA7 TPO TRH
46 ehlers-danlos syndrome, periodontal type 1 9.7 ALB OXA1L SERPINA7 TTR
47 pulsating exophthalmos 9.7 SERPINA7 TPO
48 rickets 9.7
49 goiter 9.7
50 graves' disease 9.7

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to Hyperthyroxinemia

Symptoms & Phenotypes for Hyperthyroxinemia

Drugs & Therapeutics for Hyperthyroxinemia

Search Clinical Trials , NIH Clinical Center for Hyperthyroxinemia

Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

Anatomical Context for Hyperthyroxinemia

MalaCards organs/tissues related to Hyperthyroxinemia:

39
Thyroid, Pituitary, Testes

Publications for Hyperthyroxinemia

Articles related to Hyperthyroxinemia:

(show top 50) (show all 129)
id Title Authors Year
1
First Report of Familial Dysalbuminemic Hyperthyroxinemia With an ALB Variant. ( 27834068 )
2017
2
Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Man Caused by a Point Albumin Gene Mutation (R218P). ( 27081329 )
2016
3
Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia. ( 26777880 )
2016
4
A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH). ( 27904073 )
2016
5
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. ( 25153218 )
2014
6
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. ( 24646103 )
2014
7
Lithium-induced transient euthyroid hyperthyroxinemia: a case report. ( 25133055 )
2014
8
Anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia and suspected impairment of T4 to T3 conversion: a case report. ( 25237453 )
2014
9
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. ( 24494774 )
2014
10
[Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. ( 22781450 )
2012
11
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. ( 21149501 )
2011
12
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. ( 19282355 )
2009
13
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. ( 18724828 )
2008
14
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. ( 17190692 )
2006
15
Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. ( 15833783 )
2005
16
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. ( 15068631 )
2004
17
[The specific features of thyrotoxicosis and euthyroid hyperthyroxinemia developed due to the use of cordarone]. ( 15732718 )
2004
18
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. ( 12743361 )
2003
19
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. ( 12099390 )
2002
20
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. ( 11743520 )
2001
21
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. ( 11385707 )
2001
22
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. ( 10946882 )
2000
23
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. ( 10526251 )
1999
24
A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? ( 10999134 )
1999
25
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. ( 10430791 )
1999
26
[Hyperthyroxinemia and clinical euthyroidism. Report of one case]. ( 10436700 )
1999
27
Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. ( 10352382 )
1999
28
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. ( 9329347 )
1997
29
Etiology and outcome of non-estrogen associated hyperthyroxinemia in euthyroid patients at the San Juan City Hospital. ( 8885441 )
1996
30
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. ( 8702585 )
1996
31
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( 8784093 )
1996
32
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. ( 8929830 )
1996
33
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. ( 8964572 )
1996
34
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. ( 15251607 )
1995
35
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. ( 7829599 )
1995
36
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. ( 7852505 )
1995
37
Familial dysalbuminemic hyperthyroxinemia in pregnancy. ( 8548059 )
1995
38
Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report. ( 8648063 )
1995
39
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. ( 7628382 )
1995
40
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. ( 7742472 )
1994
41
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. ( 8048949 )
1994
42
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. ( 8288714 )
1994
43
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. ( 7937417 )
1994
44
[Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. ( 8196175 )
1994
45
Hyperthyroxinemia after surgery for primary hyperparathyroidism. ( 8052060 )
1994
46
Free thyroxine measured by the Ciba Corning ACS-180 on samples from patients with familial dysalbuminemic hyperthyroxinemia. ( 8353971 )
1993
47
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. ( 8422721 )
1993
48
Thyroid scintigraphy of hyperthyroxinemia. ( 8269684 )
1993
49
Effect of short-term hyperthyroxinemia on vitamin D metabolism in congenital hypothyroidism. ( 8406326 )
1993
50
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. ( 8353966 )
1993

Variations for Hyperthyroxinemia

Expression for Hyperthyroxinemia

Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for Hyperthyroxinemia

Pathways related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.32 ALB SERPINA7 TPO TTR
2 10.8 ALB TTR
3 9.73 TPO TRH

GO Terms for Hyperthyroxinemia

Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 ALB SERPINA7 TPO TTR
2 protein complex GO:0043234 8.8 ALB OXA1L TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 8.96 ALB TPO
2 thyroid hormone transport GO:0070327 8.62 SERPINA7 TTR

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TRH TTR

Sources for Hyperthyroxinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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