MCID: HYP029
MIFTS: 39

Hyperthyroxinemia malady

Summaries for Hyperthyroxinemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards: Hyperthyroxinemia is related to thyrotoxicosis and congenital hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (transthyretin), and among its related pathways are Phenylalanine metabolism and Class A/1 (Rhodopsin-like receptors). The compounds idpn and t4 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pancreatic islet and pituitary, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Hyperthyroxinemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH
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Aliases & Descriptions:

hyperthyroxinemia 8 10 45 61


External Ids:

Disease Ontology8 DOID:2855
MeSH35 D006981

Related Diseases for Hyperthyroxinemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1thyrotoxicosis30.2THRB, TRH, TPO, TSHR, SERPINA7
2congenital hypothyroidism30.1SERPINA7, TPO, TSHR
3thyroid hormone resistance syndrome30.1SERPINA7, TRH, THRB
4multinodular goiter29.9TPO, TSHR
5graves' disease29.9SERPINA7, THRB, TSHR, TPO
6thyroiditis29.9TRH, CD79A, SERPINA7, TSHR, TPO
7adenoma29.9PRL, TRH, THRB, TSHR, TPO
8dysalbuminemic hyperthyroxinemia10.8
9hyperthyroxinemia dystransthyretinemic euthyroidal10.3
10acquired immunodeficiency syndrome10.0ALB
11pancreatitis10.0ALB
12arthritis10.0ALB
13lung cancer10.0ALB
14addison's disease10.0TPO
15hepatitis c10.0ALB
16peritonitis10.0ALB
17endogenous depression10.0TRH
18lymphatic system disease10.0ALB
19neonatal thyrotoxicosis10.0TSHR
20melancholia10.0TRH
21hepatitis10.0SERPINA7, TTR
22protein-energy malnutrition10.0TTR, ALB
23prion disease10.0CD79A
24alzheimer's disease10.0TTR, OXA1L
25conjunctivitis10.0CD79A
26poems syndrome10.0CD79A
27proliferative glomerulonephritis10.0CD79A
28coronary heart disease10.0OXA1L
29nutritional deficiency disease10.0ALB, TTR
30protein-losing enteropathy10.0ALB, OXA1L
31endemic goiter10.0TPO, TSHR
32nontoxic goiter10.0TSHR, TPO
33measles10.0CD79A
34insulin resistance10.0ALB, TTR
35myxedema10.0TPO, TSHR
36lupus erythematosus10.0CD79A
37myocardial infarction10.0TPO, OXA1L
38down syndrome10.0TSHR, TPO
39growth hormone deficiency10.0PRL
40euthyroid sick syndrome10.0TRH, SERPINA7
41gastroenteritis10.0CD79A
42subacute thyroiditis10.0TSHR, TPO
43diphtheria10.0CD79A
44thyroid agenesis10.0SERPINA7, TSHR
45toxic diffuse goiter10.0TSHR, TPO
46pemphigus10.0CD79A
47viral hepatitis10.0TSHR
48exophthalmos10.0TSHR, TRH
49uremia10.0ALB, OXA1L
50candidiasis10.0CD79A

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Clinical Features for Hyperthyroxinemia

Drugs & Therapeutics for Hyperthyroxinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hyperthyroxinemia

Drug clinical trials:

Search ClinicalTrials for Hyperthyroxinemia

Search NIH Clinical Center for Hyperthyroxinemia

Search CenterWatch for Hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

Anatomical Context for Hyperthyroxinemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hyperthyroxinemia:

33
Thyroid, Pancreatic islet, Pituitary

Animal Models for Hyperthyroxinemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hyperthyroxinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2TSHR
2MP:00053766.7TPO, PRL, TRH, CD79A, TTR, THRB

Publications for Hyperthyroxinemia

Sources:
51PubMed
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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. (22781450)
2012
2
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. (15068631)
2004
3
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. (12743361)
2003
4
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. (10526251)
1999
5
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
6
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. (8964572)
1996
7
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. (8702585)
1996
8
Familial dysalbuminemic hyperthyroxinemia in pregnancy. (8548059)
1995
9
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
10
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
11
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. (8288714)
1994
12
Hyperthyroxinemia after surgery for primary hyperparathyroidism. (8052060)
1994
13
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
14
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
15
Fluorescence investigations of albumin from patients with familial dysalbuminemic hyperthyroxinemia. (8475173)
1993
16
Hyperthyroxinemia in major affective disorders. (2011957)
1991
17
Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report. (1769174)
1991
18
Heterogeneity of serum prolactin in patients with menstrual disorder in conjunction with hyperthyroxinemia. (1774453)
1991
19
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
20
Transient prealbumin-associated hyperthyroxinemia in TSH-producing pituitary adenoma. (2108434)
1990
21
Studies on the nature of iodothyronine binding in familial dysalbuminemic hyperthyroxinemia. (2370303)
1990
22
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
23
Hyperthyroxinemia in patients receiving thyroid replacement therapy. (2705841)
1989
24
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
25
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
26
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
27
Thyroxin binding by human serum albumin after denaturation of the thyroxin-binding globulin in familial dysalbuminemic hyperthyroxinemia. (3129213)
1988
28
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
29
Euthyroid hyperthyroxinemia and inappropriate secretion of thyrotropin. Recognition and diagnosis. (3111399)
1987
30
Propranolol-induced hyperthyroxinemia in a patient with an autonomous thyroid nodule. (3612041)
1987
31
Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. (3112186)
1987
32
Familial dysalbuminemic hyperthyroxinemia. (3111180)
1987
33
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
34
Transient hyperthyroxinemia in symptomatic hyponatremic patients. (3954527)
1986
35
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
36
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
37
Familial euthyroid hyperthyroxinemia secondary to pituitary and peripheral resistance to thyroid hormones. (2981377)
1985
38
Euthyroid hyperthyroxinemia and rapid cycling affective disorder: case report. (3968047)
1985
39
Hepatic bioavailability of thyroxine and testosterone in familial dysalbuminemic hyperthyroxinemia. (4031018)
1985
40
The diagnostic challenge of euthyroid hyperthyroxinemia. (3927889)
1985
41
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
42
Case report: familial dysalbuminemic hyperthyroxinemia--a variant. (6590861)
1984
43
Euthyroid hyperthyroxinemia. (6368663)
1983
44
Propranolol-induced hyperthyroxinemia. (6574327)
1983
45
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
46
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
47
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
48
Euthyroid familial hyperthyroxinemia due to abnormal thyroid hormone-binding protein. (6287840)
1982
49
Hyperthyroxinemia and hypotriiodothyroninemia with clinical euthyroidism. (7246597)
1981
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Genetic Variations for Hyperthyroxinemia

Expression for genes affiliated with Hyperthyroxinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperthyroxinemia

Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for genes affiliated with Hyperthyroxinemia

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30KEGG, 54Reactome
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Pathways related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TPO, ADH5
2
Hide members
8.4TSHR, THRA, THRB, TRH, PRL

Compounds for genes affiliated with Hyperthyroxinemia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Hyperthyroxinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1idpn4510.2TTR, ALB
2t42910.0THRA, THRB
3reverse triiodothyronine2910.0THRB, THRA
43,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid1110.0THRB, THRA
53,3,5-triiodothyroacetic acid2910.0THRA, THRB
6kb-141299.9THRB, THRA
7sodium octanoate459.9ALB, OXA1L
8azapropazone45 1110.8OXA1L, ALB
9Dextrothyroxine119.8THRA, THRB, TPO
10tolmetin glucuronide459.8OXA1L, ALB
11amiodarone45 50 29 1112.8THRB, TPO, SERPINA7
12dansylsarcosine459.8OXA1L, ALB
13rhsa459.7ALB, OXA1L
14nh-3299.7THRB, THRA
15pirprofen459.7ALB, OXA1L
16flurbiprofen45 29 50 1112.7ALB, TTR, OXA1L
17gc-1299.7THRB, THRA
18vitamin d459.7THRA, THRB, CD79A
19125i459.6SERPINA7, TSHR, TPO
20piroxicam45 1110.6ALB, CD79A, OXA1L
21t3299.6THRB, THRA
22iodine45 2410.5TSHR, SERPINA7, TRH, TPO
23l-tryptophan45 29 11 2412.5OXA1L, ALB, PRL
24diflunisal45 1110.5TTR, SERPINA7, ALB, OXA1L
25urea45 11 2411.5TRH, TTR, ALB, SERPINA7
26methimazole45 2 1111.5TRH, TPO, TSHR, SERPINA7
27salicylic acid45 2910.5ALB, SERPINA7, TTR, OXA1L
28phenytoin45 50 29 1112.4SERPINA7, CD79A, OXA1L, ALB
29Levothyroxine119.4THRA, THRB, SERPINA7, TTR, ALB
30Liotrix119.4SERPINA7, THRB, TTR, THRA, ALB
31kebuzone459.3OXA1L, ALB
32ribonucleic acid459.1PRL, THRB, TPO, TSHR, SERPINA7
33acth459.1TRH, SERPINA7, TPO, TSHR, PRL
34Liothyronine11 2410.1TPO, ALB, THRA, THRB, TTR, SERPINA7
35fibrinogen459.1OXA1L, ALB, TPO, CD79A, TTR
36cholesterol45 29 11 2412.0TTR, TPO, TSHR, ALB, SERPINA7, THRB
37polyethylene glycol458.9PRL, OXA1L, CD79A, TSHR, ALB
38glutaraldehyde458.9CD79A, ALB, OXA1L, TTR, TRH
39sodium dodecylsulfate458.9SERPINA7, TTR, ALB, TPO, OXA1L, CD79A
40estradiol45 11 2410.8PRL, TRH, THRA, TSHR, ALB, SERPINA7
41alanine458.7ADH5, CD79A, TTR, THRB, SERPINA7, ALB
42cysteine458.6TPO, ALB, TSHR, THRB, OXA1L, CD79A
43progesterone45 60 29 11 2412.5TSHR, THRA, THRB, SERPINA7, PRL, TRH
44retinoic acid45 249.5THRA, ADH5, TSHR, TPO, TTR, CD79A
45triiodothyronine458.1TRH, PRL, TTR, THRB, THRA, SERPINA7
46testosterone45 60 11 2411.1ALB, THRB, PRL, TRH, CD79A, TTR
47glucose458.1TSHR, SERPINA7, PRL, TTR, TRH, ALB
48estrogen458.0PRL, TSHR, TRH, SERPINA7, CD79A, TTR
49arginine457.7SERPINA7, PRL, THRB, TRH, CD79A, ADH5
50thyroxine45 247.8PRL, THRA, THRB, TTR, CD79A, OXA1L

GO Terms for genes affiliated with Hyperthyroxinemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosterone stimulusGO:0514129.7SERPINA7, TRH
2female courtship behaviorGO:0080509.6THRA, THRB
3hormone-mediated signaling pathwayGO:0097559.3THRA, TRH

Molecular functions related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:0425629.9SERPINA7, TTR
2thyroid hormone bindingGO:0703249.7THRB, THRA
3thyroid hormone receptor activityGO:0048879.7THRA, THRB
4chromatin DNA bindingGO:0314909.7THRA, THRB
5fatty acid bindingGO:0055049.6ALB, ADH5

Products for genes affiliated with Hyperthyroxinemia

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Sources for Hyperthyroxinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet