MCID: HYP029
MIFTS: 43

Hyperthyroxinemia malady

Endocrine diseases category
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Summaries for Hyperthyroxinemia

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Wikipedia:65 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards based summary: Hyperthyroxinemia is related to thyroid hormone resistance syndrome and hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (transthyretin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Thyroxine (Thyroid Hormone) Production. The compounds idpn and rhsa have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Hyperthyroxinemia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH
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Hyperthyroxinemia, Aliases & Descriptions:

Name: Hyperthyroxinemia 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:2855
MeSH34 D006981

Related Diseases for Hyperthyroxinemia

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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid hormone resistance syndrome30.7SERPINA7, TRH
2hypothyroidism30.6TRH, TSHR, TPO
3thyroiditis30.6TPO, SERPINA7, TSHR, CD79A, TRH
4congenital hypothyroidism30.5TPO, SERPINA7, TSHR
5multinodular goiter30.5TPO, TSHR
6thyrotoxicosis30.4TRH, TSHR, SERPINA7, TPO
7autoimmune thyroiditis30.3TSHR, SERPINA7, TPO
8graves' disease30.3TPO, SERPINA7, TSHR
9hyperprolactinemia30.3TRH, PRL
10pituitary adenoma30.1SERPINA7, PRL, TRH
11myeloma30.0OXA1L, ALB, CD79A
12goiter30.0TPO, SERPINA7, TSHR, TRH
13adenoma29.8TRH, PRL, TSHR, TPO
14hyperthyroidism29.7TPO, SERPINA7, TSHR, PRL, TRH
15dysalbuminemic hyperthyroxinemia10.8
16endogenous depression10.5TRH
17melancholia10.5TRH
18acquired immunodeficiency syndrome10.4ALB
19nutritional deficiency disease10.4TTR, ALB
20acth deficiency10.4PRL
21protein-energy malnutrition10.4TTR, ALB
22protein-losing enteropathy10.4OXA1L, ALB
23autonomic neuropathy10.4TTR, ALB
24rubella10.4CD79A
25brain edema10.4OXA1L, ALB
26pyelonephritis10.4CD79A
27acute poststreptococcal glomerulonephritis10.4CD79A
28thyroid agenesis10.4SERPINA7, TSHR
29endemic goiter10.4TSHR, TPO
30myxedema10.4TPO, TSHR
31subacute thyroiditis10.4TPO, TSHR
32toxic diffuse goiter10.4TSHR, TPO
33nontoxic goiter10.4TPO, TSHR
34euthyroid sick syndrome10.4TRH, SERPINA7
35gastroenteritis10.3CD79A
36turner syndrome10.3SERPINA7, TPO
37nodular goiter10.3TPO, TSHR
38exophthalmos10.3TSHR, TRH
39follicular thyroid carcinoma10.3TSHR, TPO
40papillary thyroid carcinoma10.3TPO, TSHR
41galactosemia10.3TTR, ALB
42thyrotropin deficiency, isolated10.3PRL, TPO
43thyroid cancer, anaplastic10.3TPO, TSHR
44primary hyperoxaluria10.3ALB, OXA1L, TTR
45peripheral vascular disease10.3CD79A, ALB
46premature ovarian failure10.3TPO, PRL
47lipoid nephrosis10.3ALB, CD79A
48hyperhomocysteinemia10.3TTR, ALB
49membranous glomerulonephritis10.2ALB, CD79A
50empty sella syndrome10.2PRL, TRH

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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Drug clinical trials:

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Search NIH Clinical Center for Hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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MalaCards organs/tissues related to Hyperthyroxinemia:

32
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperthyroxinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1TPO, TSHR, PRL, ALB, TRH, THRA
2MP:00053766.7TRH, THRA, TTR, TPO, TSHR, PRL

Publications for Hyperthyroxinemia

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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. (24494774)
2014
2
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. (24646103)
2014
3
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. (25153218)
2014
4
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
5
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
6
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. (11385707)
2001
7
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
8
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
9
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
10
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
11
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
12
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
13
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
14
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
15
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
16
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
17
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
18
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
19
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
20
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
21
Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. (2493680)
1989
22
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
23
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
24
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
25
Euthyroid hyperthyroxinemia due to a generalized 5'-deiodinase defect. (3346351)
1988
26
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
27
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
28
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
29
Euthyroid hyperthyroxinemia: a case report. (3431505)
1987
30
Thyrotropin hyperresponsiveness to TRH despite hyperthyroxinemia in amiodarone-treated subjects. (3118137)
1987
31
Specific methods to identify plasma binding abnormalities in euthyroid hyperthyroxinemia. (3079602)
1986
32
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
33
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
34
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
35
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
36
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
37
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
38
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
39
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
40
Euthyroid hyperthyroxinemia. (6368663)
1983
41
Propranolol-induced hyperthyroxinemia. (6639243)
1983
42
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin. (6412142)
1983
43
Familial hyperthyroxinemia due to abnormal thyroid hormone binding. (6800289)
1982
44
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
45
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
46
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
47
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
48
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
49
Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. (7287882)
1981
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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Expression patterns in normal tissues for genes affiliated with Hyperthyroxinemia

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Pathways for genes affiliated with Hyperthyroxinemia

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Compounds for genes affiliated with Hyperthyroxinemia

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Compounds related to Hyperthyroxinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1idpn4410.2TTR, ALB
2rhsa449.9ALB, OXA1L
3dansylsarcosine449.9OXA1L, ALB
4kebuzone449.9OXA1L, ALB
5pirprofen449.9OXA1L, ALB
6125i449.9TPO, TSHR, SERPINA7
7cellulose acetate449.9CD79A, TTR, ALB
8iodide44 2410.9TPO, SERPINA7, TSHR
9azapropazone44 1110.9ALB, OXA1L
10tolmetin glucuronide449.9OXA1L, ALB
11sodium octanoate449.9ALB, OXA1L
12acetyldigitoxin44 1110.8OXA1L, ALB
13hhpa449.8ALB, OXA1L
14flurbiprofen44 28 50 1112.7ALB, OXA1L, TTR
15diclofenac44 28 50 1112.6TTR, SERPINA7, ALB
16piroxicam44 1110.6CD79A, ALB, OXA1L
17furosemide44 61 28 50 24 1114.5SERPINA7, OXA1L, ALB
18urea44 24 1111.5SERPINA7, TTR, ALB, TRH
19eprex449.5OXA1L, ALB
20diflunisal44 1110.4ALB, OXA1L, SERPINA7, TTR
21l-tryptophan50 28 44 24 1113.4PRL, OXA1L, ALB
22iodine44 2410.4SERPINA7, TSHR, TRH, TPO
23methimazole44 2 1111.4TRH, SERPINA7, TPO, TSHR
24salicylic acid44 2810.4ALB, TTR, SERPINA7, OXA1L
25liothyronine50 24 1111.4SERPINA7, ALB, TPO, TTR, THRA
26naloxone44 28 50 1112.3ALB, PRL, TRH
27aspartate449.3ALB, TPO, SERPINA7, TSHR, TTR
28phenytoin44 50 28 1112.3ALB, OXA1L, SERPINA7, CD79A
29dansylamide44 1110.3ALB, OXA1L
30creatinine449.3TTR, CD79A, ALB, SERPINA7, TPO
31diazepam44 28 50 1112.2OXA1L, TRH, ALB
32ascorbic acid44 2410.2CD79A, ALB, TPO, TTR
33aspirin44 50 28 2412.1OXA1L, SERPINA7, TTR, CD79A
34cholesterol44 28 24 1112.1TTR, SERPINA7, TSHR, ALB, TPO
35ribonucleic acid449.1PRL, SERPINA7, TPO, TSHR
36fibrinogen449.0CD79A, ALB, TPO, TTR, OXA1L
37acth448.9TRH, TPO, SERPINA7, TSHR, PRL
38dopamine44 28 24 1111.8PRL, CD79A, TTR, TRH, SERPINA7
39glutaraldehyde448.8CD79A, OXA1L, TTR, ALB, TRH
40polyethylene glycol448.7TSHR, CD79A, ALB, OXA1L, PRL
41sodium dodecylsulfate448.7SERPINA7, ALB, OXA1L, TPO, TTR, CD79A
42progesterone44 28 61 24 1112.7TRH, PRL, TSHR, SERPINA7, THRA
43cysteine448.6TPO, CD79A, ALB, TTR, OXA1L, TSHR
44estradiol44 24 1110.6SERPINA7, TRH, ALB, PRL, TSHR, THRA
45testosterone44 61 24 1111.3CD79A, PRL, TPO, SERPINA7, ALB, TRH
46triiodothyronine448.3TTR, SERPINA7, THRA, TPO, TSHR, PRL
47glucose448.3ALB, PRL, THRA, TRH, TTR, SERPINA7
48arginine448.2TPO, TSHR, SERPINA7, TRH, CD79A, PRL
49estrogen448.1SERPINA7, TRH, TSHR, PRL, CD79A, THRA
50thyroxine44 248.0TRH, TPO, TTR, THRA, TSHR, OXA1L

GO Terms for genes affiliated with Hyperthyroxinemia

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Cellular components related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.3ALB, OXA1L, TTR
2extracellular regionGO:0055768.3TRH, ALB, PRL, SERPINA7, TTR

Biological processes related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to coldGO:0094099.6TRH, THRA
2hormone-mediated signaling pathwayGO:0097559.5TRH, THRA
3response to corticosteroneGO:0514129.4TRH, SERPINA7

Molecular functions related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:0425629.9SERPINA7, TTR

Products for genes affiliated with Hyperthyroxinemia

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Sources for Hyperthyroxinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet