MCID: HYP029
MIFTS: 28

Hyperthyroxinemia malady

Category: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

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Aliases & Descriptions for Hyperthyroxinemia:

Name: Hyperthyroxinemia 10 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:2855
MeSH36 D006981
UMLS65 C0020551

Summaries for Hyperthyroxinemia

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Wikipedia:68 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards based summary: Hyperthyroxinemia is related to pituitary adenoma and thyroid hormone resistance. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, lung and myeloid, and related mouse phenotype endocrine/exocrine gland.

Related Diseases for Hyperthyroxinemia

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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma29.7SERPINA7, TRH
2thyroid hormone resistance29.4SERPINA7, THRA, TRH
3hyperthyroxinemia, dystransthyretinemic12.2
4dysalbuminemic hyperthyroxinemia12.2
5hyperthyroxinemia, familial dysalbuminemic12.1
6thyroid hormone plasma membrane transport defect10.9
7thyroiditis10.4
8adenylosuccinase lyase deficiency10.4ALB, TTR
9calpainopathy10.3ALB, TTR
10cholestasis10.3ALB, TTR
11transvestism10.3ALB, TTR
12in situ carcinoma10.3ALB, TTR
13polydactyly10.3ALB, TTR
14congenital methemoglobinemia10.3ALB, TTR
15adult endodermal sinus tumor10.3ALB, TTR
16bladder neck cancer10.2ALB, TTR
17chronic polyneuropathy10.2ALB, TTR
18small intestinal vasoactive intestinal peptide producing tumor10.2ALB, TTR
19biliary atresia10.2ALB, TTR
20hemoglobin c disease10.2ALB, SERPINA7
21paroxysmal choreoathetosis10.1ALB, TTR
22dermoid cyst of ovary10.1ALB, TTR
23organic acidemia10.1ALB, TTR
24hepatocellular carcinoma10.0
25hypothyroidism10.0
26mesenteric vascular occlusion10.0ALB, TTR
27congenital hypothyroidism9.9
28upper lip cancer9.9ALB, TTR
29paramyloidosis9.8ALB, SERPINA7
30dystonia 49.8ALB, SERPINA7, TTR
31pheochromocytoma9.8
32hyperprolactinemia9.8
33multiple myeloma9.8
34hepatitis9.8
35multinodular goiter9.8
36myeloma9.8
37rickets9.8
38primary hyperparathyroidism9.8
39goiter9.8
40graves' disease9.8
41hyperparathyroidism9.8
42pancreatitis9.8
43conjunctivitis9.8
44adenoma9.8
45autoimmune thyroiditis9.8
46hyperthyroidism9.8
47peripheral resistance to thyroid hormones9.8
48substernal goiter9.8SERPINA7, TPO
49accommodative spasm9.7SERPINA7, TPO
50artemis deficiency9.6SERPINA7, TPO

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hyperthyroxinemia


Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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MalaCards organs/tissues related to Hyperthyroxinemia:

33
Thyroid, Lung, Myeloid, Breast, Kidney, Pituitary, Small intestine

Animal Models for Hyperthyroxinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperthyroxinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1ALB, THRA, TPO, TRH

Publications for Hyperthyroxinemia

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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. (24494774)
2014
2
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. (24646103)
2014
3
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. (25153218)
2014
4
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
5
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
6
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. (11385707)
2001
7
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
8
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
9
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
10
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
11
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
12
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
13
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
14
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
15
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
16
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
17
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
18
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
19
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
20
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
21
Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. (2493680)
1989
22
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
23
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
24
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
25
Euthyroid hyperthyroxinemia due to a generalized 5'-deiodinase defect. (3346351)
1988
26
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
27
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
28
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
29
Euthyroid hyperthyroxinemia: a case report. (3431505)
1987
30
Thyrotropin hyperresponsiveness to TRH despite hyperthyroxinemia in amiodarone-treated subjects. (3118137)
1987
31
Specific methods to identify plasma binding abnormalities in euthyroid hyperthyroxinemia. (3079602)
1986
32
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
33
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
34
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
35
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
36
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
37
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
38
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
39
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
40
Euthyroid hyperthyroxinemia. (6368663)
1983
41
Propranolol-induced hyperthyroxinemia. (6639243)
1983
42
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin. (6412142)
1983
43
Familial hyperthyroxinemia due to abnormal thyroid hormone binding. (6800289)
1982
44
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
45
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
46
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
47
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
48
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
49
Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. (7287882)
1981
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for genes affiliated with Hyperthyroxinemia

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Pathways related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6ALB, TTR
29.3TPO, TRH

GO Terms for genes affiliated with Hyperthyroxinemia

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Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular oxidant detoxificationGO:00988699.4ALB, TPO
2hormone-mediated signaling pathwayGO:00097558.8THRA, TRH

Sources for Hyperthyroxinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet