MCID: HYP029
MIFTS: 43

Hyperthyroxinemia malady

Endocrine diseases category
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Summaries for Hyperthyroxinemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards: Hyperthyroxinemia is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (transthyretin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Thyroxine (Thyroid Hormone) Production. The compounds idpn and rhsa have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Hyperthyroxinemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH
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Classifications:

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Anatomical: Endocrine diseases


Aliases & Descriptions:

hyperthyroxinemia 8 10 45 62


External Ids:

Disease Ontology8 DOID:2855
MeSH35 D006981

Related Diseases for Hyperthyroxinemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.8CD79A, TSHR, SERPINA7, TPO, TRH
2hypothyroidism30.3TRH, TPO, TSHR
3thyrotoxicosis30.3TSHR, TPO, SERPINA7, TRH
4thyroid hormone resistance syndrome30.3SERPINA7, TRH
5congenital hypothyroidism30.2TSHR, SERPINA7, TPO
6multinodular goiter30.1TSHR, TPO
7autoimmune thyroiditis30.0TPO, TSHR, SERPINA7
8graves' disease30.0TPO, TSHR, SERPINA7
9hyperprolactinemia30.0PRL, TRH
10pituitary adenoma30.0SERPINA7, TRH, PRL
11myeloma29.9CD79A, OXA1L, ALB
12goiter29.9SERPINA7, TPO, TRH, TSHR
13adenoma29.9TPO, TSHR, TRH, PRL
14hyperthyroidism29.9TPO, SERPINA7, TRH, TSHR, PRL
15dysalbuminemic hyperthyroxinemia10.8
16hyperthyroxinemia dystransthyretinemic euthyroidal10.3
17hepatocellular carcinoma10.2
18endogenous depression10.1TRH
19melancholia10.1TRH
20acquired immunodeficiency syndrome10.1ALB
21nutritional deficiency disease10.1TTR, ALB
22acth deficiency10.1PRL
23protein-energy malnutrition10.1TTR, ALB
24protein-losing enteropathy10.1ALB, OXA1L
25autonomic neuropathy10.1TTR, ALB
26rubella10.1CD79A
27brain edema10.1ALB, OXA1L
28pyelonephritis10.1CD79A
29acute poststreptococcal glomerulonephritis10.1CD79A
30endemic goiter10.1TSHR, TPO
31thyroid agenesis10.1SERPINA7, TSHR
32myxedema10.1TSHR, TPO
33subacute thyroiditis10.1TPO, TSHR
34toxic diffuse goiter10.1TPO, TSHR
35nontoxic goiter10.1TSHR, TPO
36euthyroid sick syndrome10.1SERPINA7, TRH
37turner syndrome10.1TPO, SERPINA7
38gastroenteritis10.1CD79A
39nodular goiter10.1TSHR, TPO
40exophthalmos10.1TSHR, TRH
41follicular thyroid carcinoma10.1TSHR, TPO
42papillary thyroid carcinoma10.1TSHR, TPO
43galactosemia10.1ALB, TTR
44thyrotropin deficiency, isolated10.1TPO, PRL
45thyroid cancer, anaplastic10.1TPO, TSHR
46primary hyperoxaluria10.1ALB, OXA1L, TTR
47peripheral vascular disease10.1ALB, CD79A
48premature ovarian failure10.1TPO, PRL
49lipoid nephrosis10.1ALB, CD79A
50hyperhomocysteinemia10.1TTR, ALB

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hyperthyroxinemia

Search NIH Clinical Center for Hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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33MalaCards
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MalaCards organs/tissues related to Hyperthyroxinemia:

33
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hyperthyroxinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1TPO, TSHR, PRL, ALB, TRH, THRA
2MP:00053766.7TRH, THRA, TTR, TPO, TSHR, PRL

Publications for Hyperthyroxinemia

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52PubMed
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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
2
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
3
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. (11385707)
2001
4
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
5
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
6
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
7
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
8
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
9
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
10
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
11
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
12
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
13
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
14
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
15
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
16
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
17
A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. (1979335)
1990
18
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
19
Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. (2493680)
1989
20
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
21
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
22
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
23
Euthyroid hyperthyroxinemia due to a generalized 5'-deiodinase defect. (3346351)
1988
24
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
25
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
26
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
27
Euthyroid hyperthyroxinemia: a case report. (3431505)
1987
28
Thyrotropin hyperresponsiveness to TRH despite hyperthyroxinemia in amiodarone-treated subjects. (3118137)
1987
29
Specific methods to identify plasma binding abnormalities in euthyroid hyperthyroxinemia. (3079602)
1986
30
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
31
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
32
Concentration of free thyroxin in serum of a patient with euthyroid hyperthyroxinemia secondary to increased thyroxin-binding prealbumin: results by various methods compared. (3082534)
1986
33
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
34
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
35
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
36
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
37
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
38
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
39
Euthyroid hyperthyroxinemia. (6368663)
1983
40
Propranolol-induced hyperthyroxinemia. (6639243)
1983
41
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin. (6412142)
1983
42
Familial hyperthyroxinemia due to abnormal thyroid hormone binding. (6800289)
1982
43
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
44
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
45
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
46
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
47
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
48
Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. (7287882)
1981
49
Amphetamine-induced hyperthyroxinemia. (6782925)
1980
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperthyroxinemia

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Pathways for genes affiliated with Hyperthyroxinemia

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG
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Compounds for genes affiliated with Hyperthyroxinemia

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Hyperthyroxinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1idpn4510.2TTR, ALB
2rhsa459.9ALB, OXA1L
3dansylsarcosine459.9OXA1L, ALB
4kebuzone459.9OXA1L, ALB
5pirprofen459.9OXA1L, ALB
6125i459.9TPO, TSHR, SERPINA7
7cellulose acetate459.9CD79A, TTR, ALB
8iodide45 2410.9TPO, SERPINA7, TSHR
9azapropazone45 1110.9ALB, OXA1L
10tolmetin glucuronide459.9OXA1L, ALB
11sodium octanoate459.9ALB, OXA1L
12acetyldigitoxin45 1110.8OXA1L, ALB
13hhpa459.8ALB, OXA1L
14flurbiprofen45 29 51 1112.7ALB, OXA1L, TTR
15diclofenac45 29 51 1112.6TTR, SERPINA7, ALB
16piroxicam45 1110.6CD79A, ALB, OXA1L
17furosemide45 61 29 51 24 1114.5SERPINA7, OXA1L, ALB
18urea45 24 1111.5SERPINA7, TTR, ALB, TRH
19eprex459.5OXA1L, ALB
20diflunisal45 1110.4ALB, OXA1L, SERPINA7, TTR
21l-tryptophan51 29 45 24 1113.4PRL, OXA1L, ALB
22iodine45 2410.4SERPINA7, TSHR, TRH, TPO
23methimazole45 3 1111.4TRH, SERPINA7, TPO, TSHR
24salicylic acid45 2910.4ALB, TTR, SERPINA7, OXA1L
25liothyronine51 24 1111.4SERPINA7, ALB, TPO, TTR, THRA
26naloxone45 29 51 1112.3ALB, PRL, TRH
27aspartate459.3ALB, TPO, SERPINA7, TSHR, TTR
28phenytoin45 51 29 1112.3ALB, OXA1L, SERPINA7, CD79A
29dansylamide45 1110.3ALB, OXA1L
30creatinine459.3TTR, CD79A, ALB, SERPINA7, TPO
31diazepam45 29 51 1112.2OXA1L, TRH, ALB
32ascorbic acid45 2410.2CD79A, ALB, TPO, TTR
33aspirin45 51 29 2412.1OXA1L, SERPINA7, TTR, CD79A
34cholesterol45 29 24 1112.1TTR, SERPINA7, TSHR, ALB, TPO
35ribonucleic acid459.1PRL, SERPINA7, TPO, TSHR
36fibrinogen459.0CD79A, ALB, TPO, TTR, OXA1L
37acth458.9TRH, TPO, SERPINA7, TSHR, PRL
38dopamine45 29 24 1111.8PRL, CD79A, TTR, TRH, SERPINA7
39glutaraldehyde458.8CD79A, OXA1L, TTR, ALB, TRH
40polyethylene glycol458.7TSHR, CD79A, ALB, OXA1L, PRL
41sodium dodecylsulfate458.7SERPINA7, ALB, OXA1L, TPO, TTR, CD79A
42progesterone45 29 61 24 1112.7TRH, PRL, TSHR, SERPINA7, THRA
43cysteine458.6TPO, CD79A, ALB, TTR, OXA1L, TSHR
44estradiol45 24 1110.6SERPINA7, TRH, ALB, PRL, TSHR, THRA
45testosterone45 61 24 1111.3CD79A, PRL, TPO, SERPINA7, ALB, TRH
46triiodothyronine458.3TTR, SERPINA7, THRA, TPO, TSHR, PRL
47glucose458.3ALB, PRL, THRA, TRH, TTR, SERPINA7
48arginine458.2TPO, TSHR, SERPINA7, TRH, CD79A, PRL
49estrogen458.1SERPINA7, TRH, TSHR, PRL, CD79A, THRA
50thyroxine45 248.0TRH, TPO, TTR, THRA, TSHR, OXA1L

GO Terms for genes affiliated with Hyperthyroxinemia

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16Gene Ontology
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Cellular components related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.3ALB, OXA1L, TTR
2extracellular regionGO:0055768.3TRH, ALB, PRL, SERPINA7, TTR

Biological processes related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to coldGO:0094099.6TRH, THRA
2hormone-mediated signaling pathwayGO:0097559.5TRH, THRA
3response to corticosteroneGO:0514129.4TRH, SERPINA7

Molecular functions related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:0425629.9SERPINA7, TTR

Products for genes affiliated with Hyperthyroxinemia

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Sources for Hyperthyroxinemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet