MCID: HYP029
MIFTS: 25

Hyperthyroxinemia malady

Category: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

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Aliases & Descriptions for Hyperthyroxinemia:

Name: Hyperthyroxinemia 11 13 48 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:2855
MeSH37 D006981

Summaries for Hyperthyroxinemia

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Wikipedia:69 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards based summary: Hyperthyroxinemia is related to thyroid hormone resistance and hyperthyroxinemia, dystransthyretinemic. An important gene associated with Hyperthyroxinemia is ALB (Albumin), and among its related pathways is FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include thyroid, pituitary and testes.

Related Diseases for Hyperthyroxinemia

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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid hormone resistance29.0SERPINA7, THRA, TRH
2hyperthyroxinemia, dystransthyretinemic12.2
3dysalbuminemic hyperthyroxinemia12.2
4hyperthyroxinemia, familial dysalbuminemic12.2
5thyroid hormone plasma membrane transport defect10.9
6thyroiditis10.4
7armfield syndrome10.4ALB, TTR
8hematocele of tunica vaginalis testis10.3ALB, TTR
9cartilage disease10.3ALB, TTR
10alveolar periostitis10.3ALB, TTR
11speech and communication disorders10.3ALB, TTR
12vascular dementia10.3ALB, TTR
13constrictive pericarditis10.3ALB, TTR
14balantidiasis10.3ALB, TTR
15hemoglobinopathy10.3ALB, SERPINA7
16urinary bladder posterior wall cancer10.3ALB, TTR
17ovarian cystic teratoma10.2ALB, TTR
18central nervous system adult germ cell tumor10.2ALB, TTR
19pancreatic vasoactive intestinal peptide producing tumor10.2ALB, TTR
20acute necrotizing encephalitis10.2ALB, TTR
21extrahepatic cholestasis10.2ALB, TTR
22chronic myelomonocytic leukemia10.1ALB, TTR
23hepatocellular carcinoma10.0
24hypothyroidism10.0
25squamous cell papilloma10.0ALB, TTR
26chronic intestinal vascular insufficiency10.0ALB, TTR
27congenital hypothyroidism9.9
28survival motor neuron spinal muscular atrophy9.9ALB, TTR
29cerebral lipidosis9.9SERPINA7, TRH
30dystonia 49.9ALB, SERPINA7, TTR
31hypertelorism, preauricular sinus, punctal pits, and deafness9.8SERPINA7, TRH
32pheochromocytoma9.8
33hyperprolactinemia9.8
34multiple myeloma9.8
35hepatitis9.8
36multinodular goiter9.8
37myeloma9.8
38rickets9.8
39primary hyperparathyroidism9.8
40goiter9.8
41graves' disease9.8
42hyperparathyroidism9.8
43pituitary adenoma9.8
44pancreatitis9.8
45conjunctivitis9.8
46adenoma9.8
47autoimmune thyroiditis9.8
48hyperthyroidism9.8
49peripheral resistance to thyroid hormones9.8
50craniopharyngioma9.8SERPINA7, TRH

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hyperthyroxinemia


Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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MalaCards organs/tissues related to Hyperthyroxinemia:

34
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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Publications for Hyperthyroxinemia

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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia. (26777880)
2016
2
Anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia and suspected impairment of T4 to T3 conversion: a case report. (25237453)
2014
3
Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. (22781450)
2012
4
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
5
Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. (15833783)
2005
6
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. (12743361)
2003
7
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
8
Hyperthyroxinemia and clinical euthyroidism. Report of one case]. (10436700)
1999
9
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
10
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. (8964572)
1996
11
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. (8784093)
1996
12
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. (7829599)
1995
13
Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report. (8648063)
1995
14
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. (7628382)
1995
15
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
16
X-ray crystal structure of the Ala-109-->Thr variant of human transthyretin which produces euthyroid hyperthyroxinemia. (8428916)
1993
17
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
18
Hyperthyroxinemia in major affective disorders. (2011957)
1991
19
Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report. (1769174)
1991
20
Pheochromocytoma in a patient with hyperthyroxinemia. (1986587)
1991
21
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
22
A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. (1979335)
1990
23
Can the type of variant albumin in familial dysalbuminemic hyperthyroxinemia be determined by measuring iodothyronines in serum? (2253589)
1990
24
Hyperthyroxinemia in patients receiving thyroid replacement therapy. (2705841)
1989
25
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
26
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
27
Free thyroxin in familial dysalbuminemic hyperthyroxinemia, as measured by five assays. (3349617)
1988
28
Normal cellular uptake of thyroxine from serum of patients with familial dysalbuminemic hyperthyroxinemia or elevated thyroxine-binding globulin. (3142912)
1988
29
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
30
Thyrotropin hyperresponsiveness to TRH despite hyperthyroxinemia in amiodarone-treated subjects. (3118137)
1987
31
A four generation study of familial dysalbuminemic hyperthyroxinemia: diagnosis in the presence of an acquired excess of thyroxine-binding globulin. (3110251)
1987
32
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
33
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
34
Transient hyperthyroxinemia in symptomatic hyponatremic patients. (3954527)
1986
35
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
36
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
37
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
38
Familial euthyroid hyperthyroxinemia secondary to pituitary and peripheral resistance to thyroid hormones. (2981377)
1985
39
Euthyroid hyperthyroxinemia and rapid cycling affective disorder: case report. (3968047)
1985
40
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
41
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
42
Case report: familial dysalbuminemic hyperthyroxinemia--a variant. (6590861)
1984
43
Measurement of free thyroxin in patients with familial dysalbuminemic hyperthyroxinemia. (6705204)
1984
44
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
45
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
46
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
47
Euthyroid familial hyperthyroxinemia due to abnormal thyroid hormone-binding protein. (6287840)
1982
48
Amphetamine-induced hyperthyroxinemia. (6782925)
1980
49
Euthyroid, familial hyperthyroxinemia. (7366688)
1980
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for genes affiliated with Hyperthyroxinemia

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Pathways related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6ALB, TTR

GO Terms for genes affiliated with Hyperthyroxinemia

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Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.3ALB, SERPINA7, TRH, TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to coldGO:00094099.0THRA, TRH
2hormone-mediated signaling pathwayGO:00097558.7THRA, TRH

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone bindingGO:00703249.4THRA, TTR

Sources for Hyperthyroxinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet