MCID: HYP029
MIFTS: 25

Hyperthyroxinemia malady

Category: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

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Aliases & Descriptions for Hyperthyroxinemia:

Name: Hyperthyroxinemia 11 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:2855
MeSH39 D006981

Summaries for Hyperthyroxinemia

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Wikipedia:71 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards based summary: Hyperthyroxinemia is related to thyroid hormone resistance and hyperthyroxinemia, dystransthyretinemic. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, pituitary and testes.

Related Diseases for Hyperthyroxinemia

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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid hormone resistance29.2SERPINA7, THRA, TRH
2hyperthyroxinemia, dystransthyretinemic12.2
3hyperthyroxinemia, familial dysalbuminemic12.2
4dysalbuminemic hyperthyroxinemia12.0
5thyroid hormone plasma membrane transport defect10.8
6hematocele of tunica vaginalis testis10.3ALB, TTR
7thyroiditis10.3
8cartilage disease10.3ALB, TTR
9alveolar periostitis10.2ALB, TTR
10speech and communication disorders10.2ALB, TTR
11vascular dementia10.2ALB, TTR
12constrictive pericarditis10.2ALB, TTR
13balantidiasis10.2ALB, TTR
14hemoglobinopathy10.2ALB, SERPINA7
15urinary bladder posterior wall cancer10.2ALB, TTR
16ovarian cystic teratoma10.2ALB, TTR
17central nervous system adult germ cell tumor10.1ALB, TTR
18cerebral lipidosis10.1SERPINA7, TRH
19pancreatic vasoactive intestinal peptide producing tumor10.1ALB, TTR
20acute necrotizing encephalitis10.1ALB, TTR
21extrahepatic cholestasis10.1ALB, TTR
22chronic myelomonocytic leukemia10.0ALB, TTR
23craniopharyngioma10.0SERPINA7, TRH
24squamous cell papilloma10.0ALB, TTR
25chronic intestinal vascular insufficiency10.0ALB, TTR
26venezuelan equine encephalitis9.9ALB, TPO
27hepatocellular carcinoma9.9
28hypothyroidism9.9
29survival motor neuron spinal muscular atrophy9.9ALB, TTR
30nodular prostate9.9SERPINA7, TPO
31dystonia 49.9ALB, SERPINA7, TTR
32nodular goiter9.9SERPINA7, TPO
33congenital hypothyroidism9.8
34cd3zeta deficiency9.7SERPINA7, TPO
35lymphedema9.7ALB, TTR
36pheochromocytoma9.7
37hyperprolactinemia9.7
38multiple myeloma9.7
39hepatitis9.7
40multinodular goiter9.7
41rickets9.7
42goiter9.7
43graves' disease9.7
44hyperparathyroidism9.7
45pituitary adenoma9.7
46pancreatitis9.7
47conjunctivitis9.7
48adenoma9.7
49hyperthyroidism9.7
50peripheral resistance to thyroid hormones9.7

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms & Phenotypes for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hyperthyroxinemia


Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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MalaCards organs/tissues related to Hyperthyroxinemia:

36
Thyroid, Pituitary, Testes

Publications for Hyperthyroxinemia

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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
First Report of Familial Dysalbuminemic Hyperthyroxinemia With an ALB Variant. (27834068)
2017
2
Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia. (26777880)
2016
3
Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Man Caused by a Point Albumin Gene Mutation (R218P). (27081329)
2016
4
A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH). (27904073)
2016
5
Anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia and suspected impairment of T4 to T3 conversion: a case report. (25237453)
2014
6
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. (24494774)
2014
7
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. (24646103)
2014
8
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. (25153218)
2014
9
Lithium-induced transient euthyroid hyperthyroxinemia: a case report. (25133055)
2014
10
Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. (22781450)
2012
11
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
12
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. (19282355)
2009
13
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
14
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. (17190692)
2006
15
Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. (15833783)
2005
16
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. (15068631)
2004
17
The specific features of thyrotoxicosis and euthyroid hyperthyroxinemia developed due to the use of cordarone]. (15732718)
2004
18
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. (12743361)
2003
19
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. (12099390)
2002
20
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
21
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. (11385707)
2001
22
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. (10946882)
2000
23
Hyperthyroxinemia and clinical euthyroidism. Report of one case]. (10436700)
1999
24
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
25
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. (10526251)
1999
26
Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. (10352382)
1999
27
A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? (10999134)
1999
28
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
29
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. (8964572)
1996
30
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. (8784093)
1996
31
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. (8929830)
1996
32
Etiology and outcome of non-estrogen associated hyperthyroxinemia in euthyroid patients at the San Juan City Hospital. (8885441)
1996
33
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. (8702585)
1996
34
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. (7829599)
1995
35
Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report. (8648063)
1995
36
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. (7628382)
1995
37
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
38
Familial dysalbuminemic hyperthyroxinemia in pregnancy. (8548059)
1995
39
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (7852505)
1995
40
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
41
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. (8288714)
1994
42
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
43
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
44
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
45
Hyperthyroxinemia after surgery for primary hyperparathyroidism. (8052060)
1994
46
X-ray crystal structure of the Ala-109-->Thr variant of human transthyretin which produces euthyroid hyperthyroxinemia. (8428916)
1993
47
Fluorescence investigations of albumin from patients with familial dysalbuminemic hyperthyroxinemia. (8475173)
1993
48
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
49
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
50
Effect of short-term hyperthyroxinemia on vitamin D metabolism in congenital hypothyroidism. (8406326)
1993

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for genes affiliated with Hyperthyroxinemia

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Pathways related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6ALB, TTR
29.3TPO, TRH

GO Terms for genes affiliated with Hyperthyroxinemia

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Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.3ALB, SERPINA7, TRH, TTR
2extracellular spaceGO:00056158.5ALB, SERPINA7, TPO, TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular oxidant detoxificationGO:00988699.9ALB, TPO
2hormone-mediated signaling pathwayGO:00097559.6THRA, TRH
3response to coldGO:00094099.1THRA, TRH

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone bindingGO:00703249.2THRA, TTR

Sources for Hyperthyroxinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet