MCID: HYP029
MIFTS: 28

Hyperthyroxinemia malady

Endocrine diseases category

Aliases & Classifications for Hyperthyroxinemia

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH
See all sources

Aliases & Descriptions for Hyperthyroxinemia:

Name: Hyperthyroxinemia 10 47 12 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:2855
MeSH36 D006981

Summaries for Hyperthyroxinemia

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Wikipedia:68 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards based summary: Hyperthyroxinemia is related to thyroid hormone resistance and dysalbuminemic hyperthyroxinemia. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Related Diseases for Hyperthyroxinemia

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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid hormone resistance30.1SERPINA7, THRA, TRH
2dysalbuminemic hyperthyroxinemia10.9
3thyroiditis10.6
4hyperthyroxinemia, dystransthyretinemic10.6
5hepatocellular carcinoma10.2
6hypothyroidism10.2
7congenital hypothyroidism10.2
8thyroid hormone plasma membrane transport defect10.2
9armfield syndrome10.1ALB, TTR
10calpainopathy10.1ALB, TTR
11gastrin secretion abnormality10.1ALB, TTR
12cushing's syndrome10.1ALB, TTR
13neurofibromatosis10.1ALB, TTR
14congenital methemoglobinemia10.1ALB, TTR
15autonomic nervous system neoplasm10.1ALB, TTR
16hyperthyroxinemia10.1ALB, SERPINA7
17dysgammaglobulinemia10.1ALB, TTR
18testis sarcoma10.1ALB, TTR
19pseudohermaphroditism10.1ALB, TTR
20dendritic cell sarcoma10.1ALB, TTR
21peripheral nervous system neoplasm10.0ALB, TTR
22adiposis dolorosa10.0ALB, TTR
23posterior cerebral artery infarction10.0SERPINA7, TRH
24pheochromocytoma10.0
25hyperprolactinemia10.0
26multiple myeloma10.0
27hepatitis10.0
28multinodular goiter10.0
29graves' disease10.0
30primary hyperparathyroidism10.0
31rickets10.0
32autoimmune thyroiditis10.0
33adenoma10.0
34conjunctivitis10.0
35goiter10.0
36hyperparathyroidism10.0
37hyperthyroidism10.0
38myeloma10.0
39pancreatitis10.0
40pituitary adenoma10.0
41peripheral resistance to thyroid hormones10.0
42obstructive lung disease10.0ALB, TTR
43chronic lymphocytic leukemia10.0ALB, TTR
44urethral calculus10.0ALB, TPO
45dystonia 410.0ALB, SERPINA7, TTR
46stricture or kinking of ureter9.9SERPINA7, TPO
47subleukemic leukemia9.9SERPINA7, TPO
48hereditary night blindness9.9SERPINA7, TPO
49respiratory system benign neoplasm9.9ALB, TTR
50pseudopterygium9.8SERPINA7, TPO

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hyperthyroxinemia


Cochrane evidence based reviews: Hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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MalaCards organs/tissues related to Hyperthyroxinemia:

33
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperthyroxinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1ALB, THRA, TPO, TRH
2MP:00053767.3ALB, THRA, TPO, TRH, TTR

Publications for Hyperthyroxinemia

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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. (24494774)
2014
2
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. (24646103)
2014
3
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. (25153218)
2014
4
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
5
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
6
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. (11385707)
2001
7
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
8
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
9
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
10
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
11
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
12
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
13
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
14
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
15
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
16
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
17
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
18
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
19
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
20
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
21
Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. (2493680)
1989
22
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
23
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
24
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
25
Euthyroid hyperthyroxinemia due to a generalized 5'-deiodinase defect. (3346351)
1988
26
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
27
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
28
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
29
Euthyroid hyperthyroxinemia: a case report. (3431505)
1987
30
Thyrotropin hyperresponsiveness to TRH despite hyperthyroxinemia in amiodarone-treated subjects. (3118137)
1987
31
Specific methods to identify plasma binding abnormalities in euthyroid hyperthyroxinemia. (3079602)
1986
32
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
33
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
34
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
35
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
36
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
37
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
38
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
39
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
40
Euthyroid hyperthyroxinemia. (6368663)
1983
41
Propranolol-induced hyperthyroxinemia. (6639243)
1983
42
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin. (6412142)
1983
43
Familial hyperthyroxinemia due to abnormal thyroid hormone binding. (6800289)
1982
44
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
45
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
46
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
47
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
48
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
49
Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. (7287882)
1981
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for genes affiliated with Hyperthyroxinemia

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Pathways related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ALB, TTR
29.3TPO, TRH

GO Terms for genes affiliated with Hyperthyroxinemia

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Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5ALB, SERPINA7, TPO, TTR
2extracellular regionGO:00055768.3ALB, SERPINA7, TRH, TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to corticosteroneGO:00514129.5SERPINA7, TRH
2thyroid hormone transportGO:00703279.4SERPINA7, TTR
3response to coldGO:00094099.4THRA, TRH
4response to nutrient levelsGO:00316679.1SERPINA7, THRA
5hormone-mediated signaling pathwayGO:00097559.1THRA, TRH

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:00425629.2SERPINA7, TTR
2thyroid hormone bindingGO:00703249.2THRA, TTR

Sources for Hyperthyroxinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet