MCID: HYP029
MIFTS: 43

Hyperthyroxinemia malady

Endocrine diseases category

Summaries for Hyperthyroxinemia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards: Hyperthyroxinemia is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (transthyretin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Thyroxine (Thyroid Hormone) Production. The compounds idpn and rhsa have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Hyperthyroxinemia

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hyperthyroxinemia 9 11 46 63


External Ids:

Disease Ontology9 DOID:2855
MeSH36 D006981

Related Diseases for Hyperthyroxinemia

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18GeneCards, 19GeneDecks
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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.8CD79A, TSHR, SERPINA7, TPO, TRH
2hypothyroidism30.3TRH, TPO, TSHR
3thyrotoxicosis30.3TSHR, TPO, SERPINA7, TRH
4thyroid hormone resistance syndrome30.3SERPINA7, TRH
5congenital hypothyroidism30.2TSHR, SERPINA7, TPO
6multinodular goiter30.1TSHR, TPO
7autoimmune thyroiditis30.0TPO, TSHR, SERPINA7
8graves' disease30.0TPO, TSHR, SERPINA7
9hyperprolactinemia30.0PRL, TRH
10pituitary adenoma30.0SERPINA7, TRH, PRL
11myeloma29.9CD79A, OXA1L, ALB
12goiter29.9SERPINA7, TPO, TRH, TSHR
13adenoma29.9TPO, TSHR, TRH, PRL
14hyperthyroidism29.9TPO, SERPINA7, TRH, TSHR, PRL
15dysalbuminemic hyperthyroxinemia10.8
16hyperthyroxinemia dystransthyretinemic euthyroidal10.3
17hepatocellular carcinoma10.2
18endogenous depression10.1TRH
19melancholia10.1TRH
20acquired immunodeficiency syndrome10.1ALB
21nutritional deficiency disease10.1TTR, ALB
22acth deficiency10.1PRL
23protein-energy malnutrition10.1TTR, ALB
24protein-losing enteropathy10.1ALB, OXA1L
25autonomic neuropathy10.1TTR, ALB
26rubella10.1CD79A
27brain edema10.1ALB, OXA1L
28pyelonephritis10.1CD79A
29acute poststreptococcal glomerulonephritis10.1CD79A
30endemic goiter10.1TSHR, TPO
31thyroid agenesis10.1SERPINA7, TSHR
32myxedema10.1TSHR, TPO
33subacute thyroiditis10.1TPO, TSHR
34toxic diffuse goiter10.1TPO, TSHR
35nontoxic goiter10.1TSHR, TPO
36euthyroid sick syndrome10.1SERPINA7, TRH
37turner syndrome10.1TPO, SERPINA7
38gastroenteritis10.1CD79A
39nodular goiter10.1TSHR, TPO
40exophthalmos10.1TSHR, TRH
41follicular thyroid carcinoma10.1TSHR, TPO
42papillary thyroid carcinoma10.1TSHR, TPO
43galactosemia10.1ALB, TTR
44thyrotropin deficiency, isolated10.1TPO, PRL
45thyroid cancer, anaplastic10.1TPO, TSHR
46primary hyperoxaluria10.1ALB, OXA1L, TTR
47peripheral vascular disease10.1ALB, CD79A
48premature ovarian failure10.1TPO, PRL
49lipoid nephrosis10.1ALB, CD79A
50hyperhomocysteinemia10.1TTR, ALB

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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34MalaCards
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MalaCards organs/tissues related to Hyperthyroxinemia:

34
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hyperthyroxinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1TPO, TSHR, PRL, ALB, TRH, THRA
2MP:00053766.7TRH, THRA, TTR, TPO, TSHR, PRL

Publications for Hyperthyroxinemia

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53PubMed
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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
2
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
3
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. (11385707)
2001
4
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
5
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
6
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
7
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
8
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
9
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
10
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
11
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
12
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
13
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
14
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
15
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
16
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
17
A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. (1979335)
1990
18
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
19
Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. (2493680)
1989
20
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
21
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
22
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
23
Euthyroid hyperthyroxinemia due to a generalized 5'-deiodinase defect. (3346351)
1988
24
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
25
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
26
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
27
Euthyroid hyperthyroxinemia: a case report. (3431505)
1987
28
Thyrotropin hyperresponsiveness to TRH despite hyperthyroxinemia in amiodarone-treated subjects. (3118137)
1987
29
Specific methods to identify plasma binding abnormalities in euthyroid hyperthyroxinemia. (3079602)
1986
30
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
31
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
32
Concentration of free thyroxin in serum of a patient with euthyroid hyperthyroxinemia secondary to increased thyroxin-binding prealbumin: results by various methods compared. (3082534)
1986
33
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
34
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
35
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
36
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
37
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
38
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
39
Euthyroid hyperthyroxinemia. (6368663)
1983
40
Propranolol-induced hyperthyroxinemia. (6639243)
1983
41
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin. (6412142)
1983
42
Familial hyperthyroxinemia due to abnormal thyroid hormone binding. (6800289)
1982
43
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
44
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
45
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
46
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
47
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
48
Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. (7287882)
1981
49
Amphetamine-induced hyperthyroxinemia. (6782925)
1980
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperthyroxinemia

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Pathways for genes affiliated with Hyperthyroxinemia

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Hyperthyroxinemia

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Hyperthyroxinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1idpn4610.2TTR, ALB
2rhsa469.9ALB, OXA1L
3dansylsarcosine469.9OXA1L, ALB
4kebuzone469.9OXA1L, ALB
5pirprofen469.9OXA1L, ALB
6125i469.9TPO, TSHR, SERPINA7
7cellulose acetate469.9CD79A, TTR, ALB
8iodide46 2510.9TPO, SERPINA7, TSHR
9azapropazone46 1210.9ALB, OXA1L
10tolmetin glucuronide469.9OXA1L, ALB
11sodium octanoate469.9ALB, OXA1L
12acetyldigitoxin46 1210.8OXA1L, ALB
13hhpa469.8ALB, OXA1L
14flurbiprofen46 30 52 1212.7ALB, OXA1L, TTR
15diclofenac46 30 52 1212.6TTR, SERPINA7, ALB
16piroxicam46 1210.6CD79A, ALB, OXA1L
17furosemide46 62 30 52 25 1214.5SERPINA7, OXA1L, ALB
18urea46 25 1211.5SERPINA7, TTR, ALB, TRH
19eprex469.5OXA1L, ALB
20diflunisal46 1210.4ALB, OXA1L, SERPINA7, TTR
21l-tryptophan52 30 46 25 1213.4PRL, OXA1L, ALB
22iodine46 2510.4SERPINA7, TSHR, TRH, TPO
23methimazole46 3 1211.4TRH, SERPINA7, TPO, TSHR
24salicylic acid46 3010.4ALB, TTR, SERPINA7, OXA1L
25liothyronine52 25 1211.4SERPINA7, ALB, TPO, TTR, THRA
26naloxone46 30 52 1212.3ALB, PRL, TRH
27aspartate469.3ALB, TPO, SERPINA7, TSHR, TTR
28phenytoin46 52 30 1212.3ALB, OXA1L, SERPINA7, CD79A
29dansylamide46 1210.3ALB, OXA1L
30creatinine469.3TTR, CD79A, ALB, SERPINA7, TPO
31diazepam46 30 52 1212.2OXA1L, TRH, ALB
32ascorbic acid46 2510.2CD79A, ALB, TPO, TTR
33aspirin46 52 30 2512.1OXA1L, SERPINA7, TTR, CD79A
34cholesterol46 30 25 1212.1TTR, SERPINA7, TSHR, ALB, TPO
35ribonucleic acid469.1PRL, SERPINA7, TPO, TSHR
36fibrinogen469.0CD79A, ALB, TPO, TTR, OXA1L
37acth468.9TRH, TPO, SERPINA7, TSHR, PRL
38dopamine46 30 25 1211.8PRL, CD79A, TTR, TRH, SERPINA7
39glutaraldehyde468.8CD79A, OXA1L, TTR, ALB, TRH
40polyethylene glycol468.7TSHR, CD79A, ALB, OXA1L, PRL
41sodium dodecylsulfate468.7SERPINA7, ALB, OXA1L, TPO, TTR, CD79A
42progesterone46 30 62 25 1212.7TRH, PRL, TSHR, SERPINA7, THRA
43cysteine468.6TPO, CD79A, ALB, TTR, OXA1L, TSHR
44estradiol46 25 1210.6SERPINA7, TRH, ALB, PRL, TSHR, THRA
45testosterone46 62 25 1211.3CD79A, PRL, TPO, SERPINA7, ALB, TRH
46triiodothyronine468.3TTR, SERPINA7, THRA, TPO, TSHR, PRL
47glucose468.3ALB, PRL, THRA, TRH, TTR, SERPINA7
48arginine468.2TPO, TSHR, SERPINA7, TRH, CD79A, PRL
49estrogen468.1SERPINA7, TRH, TSHR, PRL, CD79A, THRA
50thyroxine46 258.0TRH, TPO, TTR, THRA, TSHR, OXA1L

GO Terms for genes affiliated with Hyperthyroxinemia

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17Gene Ontology
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Cellular components related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.3ALB, OXA1L, TTR
2extracellular regionGO:0055768.3TRH, ALB, PRL, SERPINA7, TTR

Biological processes related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to coldGO:0094099.6TRH, THRA
2hormone-mediated signaling pathwayGO:0097559.5TRH, THRA
3response to corticosteroneGO:0514129.4TRH, SERPINA7

Molecular functions related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:0425629.9SERPINA7, TTR

Products for genes affiliated with Hyperthyroxinemia

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Sources for Hyperthyroxinemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet