MCID: HYP029
MIFTS: 42

Hyperthyroxinemia malady

Summaries for Hyperthyroxinemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards: Hyperthyroxinemia is related to thyroiditis and hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (transthyretin), and among its related pathways are Phenylalanine metabolism and Class A/1 (Rhodopsin-like receptors). The compounds idpn and t4 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Hyperthyroxinemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

hyperthyroxinemia 8 10 44 60


External Ids:

Disease Ontology8 DOID:2855
MeSH34 D006981

Related Diseases for Hyperthyroxinemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.7TRH, CD79A, SERPINA7, TSHR, TPO
2hypothyroidism30.2TPO, TSHR, TRH
3hepatocellular carcinoma30.2THRB, OXA1L, SERPINA7, ALB
4thyrotoxicosis30.2THRB, TRH, TPO, TSHR, SERPINA7
5congenital hypothyroidism30.0SERPINA7, TPO, TSHR
6thyroid hormone resistance syndrome30.0SERPINA7, TRH, THRB
7pancreatitis29.8ALB
8hepatitis29.8SERPINA7, TTR
9conjunctivitis29.8CD79A
10multinodular goiter29.8TPO, TSHR
11autoimmune thyroiditis29.8TSHR, TPO, SERPINA7
12myeloma29.8ALB, CD79A, OXA1L
13pituitary adenoma29.8TRH, SERPINA7, PRL
14graves' disease29.8SERPINA7, THRB, TSHR, TPO
15goiter29.8TRH, THRB, TPO, TSHR, SERPINA7
16adenoma29.8PRL, TRH, THRB, TSHR, TPO
17hyperthyroidism29.8TPO, TSHR, SERPINA7, THRB, TRH, PRL
18dysalbuminemic hyperthyroxinemia10.2
19hyperthyroxinemia dystransthyretinemic euthyroidal10.2
20acquired immunodeficiency syndrome10.0ALB
21arthritis10.0ALB
22lung cancer10.0ALB
23addison's disease10.0TPO
24hepatitis c10.0ALB
25peritonitis10.0ALB
26endogenous depression10.0TRH
27neonatal thyrotoxicosis10.0TSHR
28lymphatic system disease10.0ALB
29melancholia10.0TRH
30protein-energy malnutrition10.0TTR, ALB
31prion disease10.0CD79A
32alzheimer's disease10.0TTR, OXA1L
33poems syndrome10.0CD79A
34proliferative glomerulonephritis10.0CD79A
35nutritional deficiency disease10.0ALB, TTR
36coronary heart disease10.0OXA1L
37protein-losing enteropathy10.0ALB, OXA1L
38endemic goiter10.0TPO, TSHR
39nontoxic goiter10.0TSHR, TPO
40measles10.0CD79A
41myxedema10.0TPO, TSHR
42insulin resistance10.0ALB, TTR
43myocardial infarction10.0TPO, OXA1L
44lupus erythematosus10.0CD79A
45down syndrome10.0TSHR, TPO
46growth hormone deficiency10.0PRL
47euthyroid sick syndrome10.0TRH, SERPINA7
48gastroenteritis10.0CD79A
49subacute thyroiditis10.0TSHR, TPO
50diphtheria10.0CD79A

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Clinical Features for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperthyroxinemia

Drug clinical trials:

Search ClinicalTrials for Hyperthyroxinemia

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Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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32MalaCards
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MalaCards organs/tissues related to Hyperthyroxinemia:

32
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperthyroxinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2TSHR
2MP:00053766.7TPO, PRL, TRH, CD79A, TTR, THRB

Publications for Hyperthyroxinemia

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50PubMed
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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
2
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. (17190692)
2006
3
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. (15068631)
2004
4
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. (12743361)
2003
5
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
6
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. (10946882)
2000
7
Etiology and outcome of non-estrogen associated hyperthyroxinemia in euthyroid patients at the San Juan City Hospital. (8885441)
1996
8
Familial dysalbuminemic hyperthyroxinemia in pregnancy. (8548059)
1995
9
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. (7829599)
1995
10
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
11
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
12
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
13
Hyperthyroxinemia in major affective disorders. (2011957)
1991
14
Unusual hyperthyroxinemia caused by endogenous thyroxin antibodies. (1893603)
1991
15
Heterogeneity of serum prolactin in patients with menstrual disorder in conjunction with hyperthyroxinemia. (1774453)
1991
16
A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. (1979335)
1990
17
Can the type of variant albumin in familial dysalbuminemic hyperthyroxinemia be determined by measuring iodothyronines in serum? (2253589)
1990
18
Studies on the nature of iodothyronine binding in familial dysalbuminemic hyperthyroxinemia. (2370303)
1990
19
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
20
Hyperthyroxinemia in patients receiving thyroid replacement therapy. (2705841)
1989
21
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
22
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
23
Normal cellular uptake of thyroxine from serum of patients with familial dysalbuminemic hyperthyroxinemia or elevated thyroxine-binding globulin. (3142912)
1988
24
Thyroxin binding by human serum albumin after denaturation of the thyroxin-binding globulin in familial dysalbuminemic hyperthyroxinemia. (3129213)
1988
25
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
26
Familial dysalbuminemic hyperthyroxinemia associated with primary thyroid disease. (3812513)
1987
27
Propranolol-induced hyperthyroxinemia in a patient with an autonomous thyroid nodule. (3612041)
1987
28
Hyperthyroxinemia due to the coexistence of two raised affinity thyroxine-binding proteins (albumin and prealbumin) in one family. (3098776)
1987
29
Familial dysalbuminemic hyperthyroxinemia. (3111180)
1987
30
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
31
Concentration of free thyroxin in serum of a patient with euthyroid hyperthyroxinemia secondary to increased thyroxin-binding prealbumin: results by various methods compared. (3082534)
1986
32
Transient hyperthyroxinemia in symptomatic hyponatremic patients. (3954527)
1986
33
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
34
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
35
Euthyroid hyperthyroxinemia and rapid cycling affective disorder: case report. (3968047)
1985
36
Hepatic bioavailability of thyroxine and testosterone in familial dysalbuminemic hyperthyroxinemia. (4031018)
1985
37
Euthyroid hyperthyroxinemia. (3917518)
1985
38
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
39
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
40
Measurement of free thyroxin in patients with familial dysalbuminemic hyperthyroxinemia. (6705204)
1984
41
Propranolol-induced hyperthyroxinemia. (6639243)
1983
42
Propranolol-induced hyperthyroxinemia. (6574327)
1983
43
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
44
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
45
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
46
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
47
Euthyroid familial hyperthyroxinemia due to abnormal thyroid hormone-binding protein. (6287840)
1982
48
Hyperthyroxinemia in an acute psychotic episode. (6807814)
1982
49
Amphetamine-induced hyperthyroxinemia. (6782925)
1980
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Genetic Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperthyroxinemia

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Pathways for genes affiliated with Hyperthyroxinemia

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29KEGG, 53Reactome
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Pathways related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TPO, ADH5
2
Hide members
8.4TSHR, THRA, THRB, TRH, PRL

Compounds for genes affiliated with Hyperthyroxinemia

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Hyperthyroxinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1idpn4410.2TTR, ALB
2t42810.0THRA, THRB
3reverse triiodothyronine2810.0THRB, THRA
43,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid1110.0THRB, THRA
53,3,5-triiodothyroacetic acid2810.0THRA, THRB
6kb-141289.9THRB, THRA
7sodium octanoate449.9ALB, OXA1L
8azapropazone44 1110.8OXA1L, ALB
9Dextrothyroxine119.8THRA, THRB, TPO
10tolmetin glucuronide449.8OXA1L, ALB
11amiodarone44 49 28 1112.8THRB, TPO, SERPINA7
12dansylsarcosine449.8OXA1L, ALB
13rhsa449.7ALB, OXA1L
14nh-3289.7THRB, THRA
15pirprofen449.7ALB, OXA1L
16flurbiprofen44 28 49 1112.7ALB, TTR, OXA1L
17gc-1289.7THRB, THRA
18vitamin d449.7THRA, THRB, CD79A
19125i449.6SERPINA7, TSHR, TPO
20piroxicam44 1110.6ALB, CD79A, OXA1L
21t3289.6THRB, THRA
22iodine44 2410.5TSHR, SERPINA7, TRH, TPO
23l-tryptophan44 28 11 2412.5OXA1L, ALB, PRL
24diflunisal44 1110.5TTR, SERPINA7, ALB, OXA1L
25urea44 11 2411.5TRH, TTR, ALB, SERPINA7
26methimazole44 2 1111.5TRH, TPO, TSHR, SERPINA7
27salicylic acid44 2810.5ALB, SERPINA7, TTR, OXA1L
28phenytoin44 49 28 1112.4SERPINA7, CD79A, OXA1L, ALB
29Levothyroxine119.4THRA, THRB, SERPINA7, TTR, ALB
30Liotrix119.4SERPINA7, THRB, TTR, THRA, ALB
31kebuzone449.3OXA1L, ALB
32ribonucleic acid449.1PRL, THRB, TPO, TSHR, SERPINA7
33acth449.1TRH, SERPINA7, TPO, TSHR, PRL
34Liothyronine11 2410.1TPO, ALB, THRA, THRB, TTR, SERPINA7
35fibrinogen449.1OXA1L, ALB, TPO, CD79A, TTR
36cholesterol44 28 11 2412.0TTR, TPO, TSHR, ALB, SERPINA7, THRB
37polyethylene glycol448.9PRL, OXA1L, CD79A, TSHR, ALB
38glutaraldehyde448.9CD79A, ALB, OXA1L, TTR, TRH
39sodium dodecylsulfate448.9SERPINA7, TTR, ALB, TPO, OXA1L, CD79A
40estradiol44 11 2410.8PRL, TRH, THRA, TSHR, ALB, SERPINA7
41alanine448.7ADH5, CD79A, TTR, THRB, SERPINA7, ALB
42cysteine448.6TPO, ALB, TSHR, THRB, OXA1L, CD79A
43progesterone44 59 28 11 2412.5TSHR, THRA, THRB, SERPINA7, PRL, TRH
44retinoic acid44 249.5THRA, ADH5, TSHR, TPO, TTR, CD79A
45triiodothyronine448.1TRH, PRL, TTR, THRB, THRA, SERPINA7
46testosterone44 59 11 2411.1ALB, THRB, PRL, TRH, CD79A, TTR
47glucose448.1TSHR, SERPINA7, PRL, TTR, TRH, ALB
48estrogen448.0PRL, TSHR, TRH, SERPINA7, CD79A, TTR
49arginine447.7SERPINA7, PRL, THRB, TRH, CD79A, ADH5
50thyroxine44 247.8PRL, THRA, THRB, TTR, CD79A, OXA1L

GO Terms for genes affiliated with Hyperthyroxinemia

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16Gene Ontology
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Biological processes related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosterone stimulusGO:0514129.7SERPINA7, TRH
2female courtship behaviorGO:0080509.6THRA, THRB
3hormone-mediated signaling pathwayGO:0097559.3THRA, TRH

Molecular functions related to Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:0425629.9TTR, SERPINA7
2thyroid hormone bindingGO:0703249.7THRA, THRB
3thyroid hormone receptor activityGO:0048879.7THRA, THRB
4chromatin DNA bindingGO:0314909.7THRA, THRB
5fatty acid bindingGO:0055049.6ADH5, ALB

Products for genes affiliated with Hyperthyroxinemia

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Sources for Hyperthyroxinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet