Aliases & Classifications for Hyperthyroxinemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH
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Hyperthyroxinemia, Aliases & Descriptions:

Name: Hyperthyroxinemia 9 11 43 60


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Disease Ontology9 DOID:2855
MeSH33 D006981

Summaries for Hyperthyroxinemia

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Wikipedia:63 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

MalaCards based summary: Hyperthyroxinemia is related to thyroid hormone resistance and hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (transthyretin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Thyroxine (Thyroid Hormone) Production. The compounds idpn and rhsa have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Related Diseases for Hyperthyroxinemia

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Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid hormone resistance30.8SERPINA7, TRH
2hypothyroidism30.6TRH, TSHR, TPO
3thyroiditis30.5TPO, SERPINA7, TSHR, CD79A, TRH
4congenital hypothyroidism30.5TPO, SERPINA7, TSHR
5multinodular goiter30.5TPO, TSHR
6thyrotoxicosis30.4TRH, TSHR, SERPINA7, TPO
7graves' disease30.3TPO, SERPINA7, TSHR
8hyperprolactinemia30.3TRH, PRL
9pituitary adenoma30.1SERPINA7, PRL, TRH
10goiter30.0TPO, SERPINA7, TSHR, TRH
11myeloma30.0OXA1L, ALB, CD79A
12adenoma29.8TRH, PRL, TSHR, TPO
13hyperthyroidism29.7TPO, SERPINA7, TSHR, PRL, TRH
14dysalbuminemic hyperthyroxinemia10.9
15endogenous depression10.5TRH
16melancholia10.5TRH
17acquired immunodeficiency syndrome10.4ALB
18nutritional deficiency disease10.4TTR, ALB
19acth deficiency10.4PRL
20protein-energy malnutrition10.4TTR, ALB
21protein-losing enteropathy10.4OXA1L, ALB
22hyperthyroxinemia, dystransthyretinemic10.4
23autonomic neuropathy10.4TTR, ALB
24rubella10.4CD79A
25brain edema10.4OXA1L, ALB
26pyelonephritis10.4CD79A
27acute poststreptococcal glomerulonephritis10.4CD79A
28hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.4SERPINA7, TSHR
29endemic goiter10.4TSHR, TPO
30myxedema10.4TPO, TSHR
31subacute thyroiditis10.4TPO, TSHR
32toxic diffuse goiter10.4TSHR, TPO
33nontoxic goiter10.4TPO, TSHR
34euthyroid sick syndrome10.4TRH, SERPINA7
35gastroenteritis10.3CD79A
36turner syndrome10.3SERPINA7, TPO
37nodular goiter10.3TPO, TSHR
38exophthalmos10.3TSHR, TRH
39pregnancy loss, recurrent 110.3SERPINA7, TPO
40thyroid carcinoma, follicular10.3TSHR, TPO
41thyroid carcinoma, papillary10.3TPO, TSHR
42galactosemia10.3TTR, ALB
43hypothryoidism, congenital, nongoitrous 410.3PRL, TPO
44thyroid cancer, anaplastic10.3TPO, TSHR
45primary hyperoxaluria10.3ALB, OXA1L, TTR
46peripheral vascular disease10.3CD79A, ALB
47premature ovarian failure10.3TPO, PRL
48lipoid nephrosis10.3ALB, CD79A
49hyperhomocysteinemia10.2TTR, ALB
50membranous glomerulonephritis, antenatal10.2ALB, CD79A

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to hyperthyroxinemia

Symptoms for Hyperthyroxinemia

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Drugs & Therapeutics for Hyperthyroxinemia

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Drug clinical trials:

Search ClinicalTrials for Hyperthyroxinemia

Search NIH Clinical Center for Hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

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Anatomical Context for Hyperthyroxinemia

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MalaCards organs/tissues related to Hyperthyroxinemia:

31
Thyroid, Pituitary, Testes

Animal Models for Hyperthyroxinemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperthyroxinemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1TPO, TSHR, PRL, ALB, TRH, THRA
2MP:00053766.7TRH, THRA, TTR, TPO, TSHR, PRL

Publications for Hyperthyroxinemia

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Articles related to Hyperthyroxinemia:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. (24494774)
2014
2
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. (24646103)
2014
3
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. (25153218)
2014
4
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
5
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. (18724828)
2008
6
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. (11385707)
2001
7
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
8
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
9
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
10
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
11
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
12
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. (7742472)
1994
13
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. (7937417)
1994
14
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
15
Factitious hyperthyroxinemia due to a monoclonal IgA in a case of multiple myeloma. (8353966)
1993
16
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
17
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. (1849117)
1991
18
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
19
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
20
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. (2563180)
1989
21
Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. (2493680)
1989
22
Transient hyperthyroxinemia associated with rickets. (3418738)
1988
23
The diagnostic dilemmas of hyperthyroxinemia and hypothyroxinemia. (3278505)
1988
24
Suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. (3383770)
1988
25
Euthyroid hyperthyroxinemia due to a generalized 5'-deiodinase defect. (3346351)
1988
26
Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. (3416422)
1988
27
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
28
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
29
Euthyroid hyperthyroxinemia: a case report. (3431505)
1987
30
Thyrotropin hyperresponsiveness to TRH despite hyperthyroxinemia in amiodarone-treated subjects. (3118137)
1987
31
Specific methods to identify plasma binding abnormalities in euthyroid hyperthyroxinemia. (3079602)
1986
32
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
33
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
34
Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. (2987291)
1985
35
Reversible hyperthyrotropinemia, hyperthyroxinemia, and hyperprolactinemia due to adrenal insufficiency. (4025380)
1985
36
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
37
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
38
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
39
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
40
Euthyroid hyperthyroxinemia. (6368663)
1983
41
Propranolol-induced hyperthyroxinemia. (6639243)
1983
42
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin. (6412142)
1983
43
Familial hyperthyroxinemia due to abnormal thyroid hormone binding. (6800289)
1982
44
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
45
Hyperthyroxinemia in patients with acute psychiatric disorders. (6807087)
1982
46
Hyperthyroxinemia in patients treated with high-dose propranolol. (6816067)
1982
47
Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. (6801514)
1982
48
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982
49
Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. (7287882)
1981
50
The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. (448913)
1979

Variations for Hyperthyroxinemia

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Expression for genes affiliated with Hyperthyroxinemia

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Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for genes affiliated with Hyperthyroxinemia

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Compounds for genes affiliated with Hyperthyroxinemia

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Compounds related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1idpn4310.2TTR, ALB
2rhsa439.9ALB, OXA1L
3dansylsarcosine439.9OXA1L, ALB
4kebuzone439.9OXA1L, ALB
5pirprofen439.9OXA1L, ALB
6125i439.9TPO, TSHR, SERPINA7
7cellulose acetate439.9CD79A, TTR, ALB
8iodide43 2410.9TPO, SERPINA7, TSHR
9azapropazone43 1210.9ALB, OXA1L
10tolmetin glucuronide439.9OXA1L, ALB
11sodium octanoate439.9ALB, OXA1L
12acetyldigitoxin43 1210.8OXA1L, ALB
13hhpa439.8ALB, OXA1L
14flurbiprofen43 28 49 1212.7ALB, OXA1L, TTR
15diclofenac43 28 49 1212.6TTR, SERPINA7, ALB
16piroxicam43 1210.6CD79A, ALB, OXA1L
17furosemide43 59 28 49 24 1214.5SERPINA7, OXA1L, ALB
18urea43 24 1211.5SERPINA7, TTR, ALB, TRH
19eprex439.5OXA1L, ALB
20diflunisal43 1210.4ALB, OXA1L, SERPINA7, TTR
21l-tryptophan49 28 43 24 1213.4PRL, OXA1L, ALB
22iodine43 2410.4SERPINA7, TSHR, TRH, TPO
23methimazole43 2 1211.4TRH, SERPINA7, TPO, TSHR
24salicylic acid43 2810.4ALB, TTR, SERPINA7, OXA1L
25liothyronine49 24 1211.4SERPINA7, ALB, TPO, TTR, THRA
26naloxone43 28 49 1212.3ALB, PRL, TRH
27aspartate439.3ALB, TPO, SERPINA7, TSHR, TTR
28phenytoin43 49 28 1212.3ALB, OXA1L, SERPINA7, CD79A
29dansylamide43 1210.3ALB, OXA1L
30creatinine439.3TTR, CD79A, ALB, SERPINA7, TPO
31diazepam43 28 49 1212.2OXA1L, TRH, ALB
32ascorbic acid43 2410.2CD79A, ALB, TPO, TTR
33aspirin43 49 28 2412.1OXA1L, SERPINA7, TTR, CD79A
34cholesterol43 28 24 1212.1TTR, SERPINA7, TSHR, ALB, TPO
35ribonucleic acid439.1PRL, SERPINA7, TPO, TSHR
36fibrinogen439.0CD79A, ALB, TPO, TTR, OXA1L
37acth438.9TRH, TPO, SERPINA7, TSHR, PRL
38dopamine43 28 24 1211.8PRL, CD79A, TTR, TRH, SERPINA7
39glutaraldehyde438.8CD79A, OXA1L, TTR, ALB, TRH
40polyethylene glycol438.7TSHR, CD79A, ALB, OXA1L, PRL
41sodium dodecylsulfate438.7SERPINA7, ALB, OXA1L, TPO, TTR, CD79A
42progesterone43 28 59 24 1212.7TRH, PRL, TSHR, SERPINA7, THRA
43cysteine438.6TPO, CD79A, ALB, TTR, OXA1L, TSHR
44estradiol43 24 1210.6SERPINA7, TRH, ALB, PRL, TSHR, THRA
45testosterone43 59 24 1211.3CD79A, PRL, TPO, SERPINA7, ALB, TRH
46triiodothyronine438.3TTR, SERPINA7, THRA, TPO, TSHR, PRL
47glucose438.3ALB, PRL, THRA, TRH, TTR, SERPINA7
48arginine438.2TPO, TSHR, SERPINA7, TRH, CD79A, PRL
49estrogen438.1SERPINA7, TRH, TSHR, PRL, CD79A, THRA
50thyroxine43 248.0TRH, TPO, TTR, THRA, TSHR, OXA1L

GO Terms for genes affiliated with Hyperthyroxinemia

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Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432349.3ALB, OXA1L, TTR
2extracellular regionGO:00055768.3TRH, ALB, PRL, SERPINA7, TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to coldGO:00094099.6TRH, THRA
2hormone-mediated signaling pathwayGO:00097559.5TRH, THRA
3response to corticosteroneGO:00514129.4TRH, SERPINA7

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:00425629.9SERPINA7, TTR

Products for genes affiliated with Hyperthyroxinemia

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Sources for Hyperthyroxinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet