MCID: HYP077
MIFTS: 51

Hypertrichosis malady

Skin diseases category

Summaries for Hypertrichosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertrichosis (also called Ambras syndrome) is an abnormal amount of hair growth over the body;... more...

MalaCards: Hypertrichosis, also known as hypertrichosis nos, is related to porphyria and porphyria cutanea tarda. An important gene associated with Hypertrichosis is SLC29A3 (solute carrier family 29 (equilibrative nucleoside transporter), member 3), and among its related pathways are Glucuronidation and Heme Biosynthesis. The drugs eflornithine and eflornithine hydrochloride and the compounds uroporphyrinogen i and hydroxymethylbilane have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and brain.

Aliases & Classifications for Hypertrichosis

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8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hypertrichosis 8 20 22 10 60
hypertrichosis nos 8


External Ids:

Disease Ontology8 DOID:420
NCIt39 C79597
MeSH34 D006983
ICD1025 L68, L68.9

Related Diseases for Hypertrichosis

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17GeneCards, 18GeneDecks
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Diseases related to Hypertrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 214)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria30.2PPOX, UROD
2porphyria cutanea tarda30.1PPOX, UROD, UROS
3poems syndrome29.9IGLV1-44, IGLV1-40
4hepatoerythropoietic porphyria29.6UROD, UROS
5congenital porphyria29.6UROS, UROD
6gingivitis10.5
7gingival fibromatosis with hypertrichosis10.4
8cervicitis10.3
9hypertrichosis lanuginosa congenita10.3
10ambras syndrome10.3
11cervical hypertrichosis peripheral neuropathy10.2
12hypertrichosis lanuginosa, acquired10.2
13osteochondrodysplasia10.2
14hypertrichosis congenital generalized x-linked10.2
15adenocarcinoma10.2
16hypothyroidism10.2
17barber say syndrome10.2
18cantu syndrome10.2
19isolated anterior cervical hypertrichosis10.2
20acromegaloid hypertrichosis syndrome10.1
21hypertrichosis cubiti - short stature10.1
22dermatomyositis10.1
23glaucoma10.1
24hypertrichosis, anterior cervical10.1
25histiocytosis-lymphadenopathy plus syndrome10.1
26congenital generalized hypertrichosis, ambras type10.1
27cataract - hypertrichosis - intellectual deficit10.1
28cerebritis10.0
29hypertrichosis of eyelid10.0
30alopecia10.0
31diabetes mellitus10.0
32ectropion10.0
33neurofibroma10.0
34panniculitis10.0
35polyneuropathy10.0
36scleroderma10.0
37amaurosis congenita cone-rod type with congenital hypertrichosis10.0
38cahmr syndrome10.0
39hypertrichosis universalis congenita10.0
40mucopolysaccharidosis ih10.0
41amaurosis - hypertrichosis10.0
42cutaneous porphyria10.0UROS, UROD
43papilledema10.0IGLV1-40, IGLV1-44
44variegate porphyria10.0UROD, PPOX
45hereditary coproporphyria10.0UROS, UROD, PPOX
46acute porphyria10.0PPOX, UROD
47acute intermittent porphyria10.0PPOX, UROD
48erythropoietic protoporphyria10.0UROS, PPOX
49metabolic syndrome x10.0UROS, PPOX, UROD
50congenital hypothyroidism9.9

Graphical network of the top 20 diseases related to Hypertrichosis:



Diseases related to hypertrichosis

Clinical Features for Hypertrichosis

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Drugs & Therapeutics for Hypertrichosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Hypertrichosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypertrichosis

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20GeneTests, 22GTR
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Genetic tests related to Hypertrichosis:

id Genetic test Affiliating Genes
1 Hypertrichosis20 22

Anatomical Context for Hypertrichosis

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32MalaCards
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MalaCards organs/tissues related to Hypertrichosis:

32
Skin, Pituitary, Brain, Ovary, Kidney, Colon, Smooth muscle, T cells, Breast, Thyroid, Lung, Eye, Prostate

Animal Models for Hypertrichosis or affiliated genes

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Publications for Hypertrichosis

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50PubMed
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Articles related to Hypertrichosis:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
Unusual case of hypertrichosis. (24403780)
2013
2
Successful ablation of iatrogenic intraoral hypertrichosis post mandibular reconstruction using a thermolysis hair epilation technique. (24118336)
2013
3
Hairy pinnae after orchiectomy and chemotherapy for testicular cancer: acquired localized hypertrichosis of the ears. (21464562)
2011
4
Hypertrichosis due to Congenital Hypothyroidism. (21769236)
2011
5
Nevoid hypertrichosis: case report with review of the literature. (22223975)
2011
6
Traumatic panniculitis with hypertrichosis. (21540142)
2011
7
A boy with mental retardation, obesity and hypertrichosis caused by a microdeletion of 19p13.12. (20570643)
2010
8
An unusual case of localised hypertrichosis. (21116429)
2010
9
Happle-Tinschert syndrome. Segmentally arranged basaloid follicular hamartomas, linear atrophoderma with hypo- and hyperpigmentation, enamel defects, ipsilateral hypertrichosis, and skeletal and cerebral anomalies. (19005246)
2009
10
Multiple nevoid hypertrichosis as an isolated developmental defect. (19689520)
2009
11
Temporary localized hypertrichosis after henna pseudotattoo. (18429803)
2008
12
Burning, paradoxical hypertrichosis, leukotrichia and folliculitis are four major complications of intense pulsed light hair removal therapy. (18654911)
2008
13
Hypertrichosis in a horse with alimentary T-cell lymphoma and pituitary involvement. (17459849)
2007
14
Localized hypertrichosis after intense pulsed light treatment for tattoo removal. (17451588)
2007
15
Therapy of hypertrichosis. (17760904)
2007
16
A new case of hairy elbows syndrome (hypertrichosis cubiti). (18019374)
2007
17
Hypertrichosis of the eyelashes from prostaglandin analog use: a blessing or a bother to the patient? (16503779)
2006
18
Hypertrichosis in patients with SURF1 mutations. (16222681)
2005
19
Naevoid hypertrichosis treated with alexandrite laser. (15245556)
2004
20
Clinical assessment and serum hormonal profile in prepubertal hypertrichosis. (11182631)
2000
21
Differentiation of Ambras syndrome from Hypertrichosis Universalis. (10735640)
2000
22
Depilation in a 6-month-Old with hypertrichosis: A case report. (10469420)
1999
23
A case of multiple nevoid hypertrichosis. (9198325)
1997
24
Retinal changes in familial peripheral sensory and motor neuropathy associated with anterior cervical hypertrichosis. (9310921)
1997
25
The hairy family of Burma: a four generation pedigree of congenital hypertrichosis lanuginosa. (8774541)
1996
26
Hypertrichosis in juvenile dermatomyositis. (8034810)
1994
27
Differentiation of congenital hypertrichosis from Ambras syndrome. (7889664)
1994
28
Hairy elbows syndrome (familial hypertrichosis cubiti). (8313649)
1994
29
Ambral syndrome and congenital generalized hypertrichosis. (7889653)
1994
30
Julia Pastrana, the nondescript: an example of congenital, generalized hypertrichosis terminalis with gingival hyperplasia. (8213906)
1993
31
Hypertrichosis, atrophic skin, ectropion, and macrostomia (Barber-Say syndrome): report of a new case. (8368246)
1993
32
Hypertrichosis lanuginosa acquista associated with florid cutaneous papillomatosis. (8425806)
1993
33
Craniofacial dysostosis, hypertrichosis, genital hypoplasia, ocular, dental, and digital defects: confirmation of the Gorlin-Chaudhry-Moss syndrome. (1442899)
1992
34
Hypertrichosis lanuginosa acquisita following cytotoxic chemotherapy. (1622890)
1992
35
Hypertrichosis lanuginosa acquisita. (1350133)
1992
36
Zidovudine-associated hypertrichosis and nail pigmentation in an HIV-infected patient. (1768394)
1991
37
Gingival fibromatosis, mental retardation, epilepsy and hypertrichosis. (2113016)
1990
38
Idiopathic familial gingival fibromatosis associated with mental retardation, epilepsy and hypertrichosis. (2806737)
1989
39
Hypertrichosis induced by diazoxide in idiopathic hypoglycemia of infancy. (2620758)
1989
40
Hemimaxillofacial dysplasia: a newly recognized disorder of facial asymmetry, hypertrichosis of the facial skin, unilateral enlargement of the maxilla, and hypoplastic teeth in two patients. (3477765)
1987
41
Acquired hypertrichosis lanuginosa. A case report. (2427719)
1986
42
Acquired hypertrichosis lanuginosa: a case report. (3996702)
1985
43
Hypertrichosis due to minoxidil. (518830)
1979
44
Linear melorheostotic scleroderma with hypertrichosis. (507873)
1979
45
Acquired hypertrichosis lanuginosa as a sign of internal malignant disease. (647593)
1978
46
Acquired hypertrichosis languiginosa. Report of two new cases and a review of the literature. (1100223)
1975
47
Hypertrichosis with hereditary gingival hyperplasia. (4834021)
1974
48
Idiopathic gingival hyperplasia and hypertrichosis associated with acromegaloid features. (4773221)
1973
49
A contribution to the genetics of hypertrichosis of the ear rims. (5512123)
1970
50
TWO CASES OF HAIR LOSS: ONE WITH AND ONE WITHOUT HYPERTRICHOSIS. (14277732)
1963

Genetic Variations for Hypertrichosis

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Expression for genes affiliated with Hypertrichosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrichosis

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Pathways for genes affiliated with Hypertrichosis

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Hypertrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PPOX, UROD, UROS
2
Hide members
10.1PPOX, UROD, UROS

Compounds for genes affiliated with Hypertrichosis

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Hypertrichosis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1uroporphyrinogen i44 2411.4UROD, UROS
2hydroxymethylbilane44 2411.4UROS, UROD, PPOX
3uroporphyrinogen-iii4410.4PPOX, UROS, UROD
4formyl-coa44 2411.3UROS, PPOX, UROD
5uroporphyrin i4410.3UROD, UROS
6porphyrin4410.3UROS, UROD, PPOX
7porphobilinogen44 11 2412.3PPOX, UROD, UROS
8uroporphyrin4410.3UROS, UROD
95-aminolevulinic acid44 2411.3UROD, UROS, PPOX
10protoporphyrinogen4410.2PPOX, UROD
11protoporphyrin ix44 11 2412.1PPOX, UROD
12heme28 11 2412.1PPOX, UROD, UROS
13haem449.9UROD, PPOX

GO Terms for genes affiliated with Hypertrichosis

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16Gene Ontology
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Biological processes related to Hypertrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme biosynthetic processGO:00678310.1PPOX, UROD, UROS
2protoporphyrinogen IX biosynthetic processGO:00678210.0PPOX, UROD, UROS
3porphyrin-containing compound metabolic processGO:0067789.8PPOX, UROD, UROS

Products for genes affiliated with Hypertrichosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertrichosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet