MCID: HYP077
MIFTS: 51

Hypertrichosis malady

Skin diseases category

Summaries for Hypertrichosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertrichosis (also called Ambras syndrome) is an abnormal amount of hair growth over the body;... more...

MalaCards: Hypertrichosis, also known as hypertrichosis nos, is related to porphyria and porphyria cutanea tarda. An important gene associated with Hypertrichosis is SLC29A3 (solute carrier family 29 (equilibrative nucleoside transporter), member 3), and among its related pathways are Glucuronidation and Heme Biosynthesis. The drugs eflornithine and eflornithine hydrochloride and the compounds uroporphyrinogen i and hydroxymethylbilane have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and brain.

Aliases & Classifications for Hypertrichosis

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8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hypertrichosis 8 20 22 10 60
hypertrichosis nos 8


External Ids:

Disease Ontology8 DOID:420
NCIt39 C79597
MeSH34 D006983
ICD1025 L68, L68.9

Related Diseases for Hypertrichosis

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17GeneCards, 18GeneDecks
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Diseases related to Hypertrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 214)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria30.2PPOX, UROD
2porphyria cutanea tarda30.1PPOX, UROD, UROS
3poems syndrome29.9IGLV1-44, IGLV1-40
4hepatoerythropoietic porphyria29.6UROD, UROS
5congenital porphyria29.6UROS, UROD
6gingivitis10.5
7gingival fibromatosis with hypertrichosis10.4
8cervicitis10.3
9hypertrichosis lanuginosa congenita10.3
10ambras syndrome10.3
11cervical hypertrichosis peripheral neuropathy10.2
12hypertrichosis lanuginosa, acquired10.2
13osteochondrodysplasia10.2
14hypertrichosis congenital generalized x-linked10.2
15adenocarcinoma10.2
16hypothyroidism10.2
17barber say syndrome10.2
18cantu syndrome10.2
19isolated anterior cervical hypertrichosis10.2
20acromegaloid hypertrichosis syndrome10.1
21hypertrichosis cubiti - short stature10.1
22dermatomyositis10.1
23glaucoma10.1
24hypertrichosis, anterior cervical10.1
25histiocytosis-lymphadenopathy plus syndrome10.1
26congenital generalized hypertrichosis, ambras type10.1
27cataract - hypertrichosis - intellectual deficit10.1
28cerebritis10.0
29hypertrichosis of eyelid10.0
30alopecia10.0
31diabetes mellitus10.0
32ectropion10.0
33neurofibroma10.0
34panniculitis10.0
35polyneuropathy10.0
36scleroderma10.0
37amaurosis congenita cone-rod type with congenital hypertrichosis10.0
38cahmr syndrome10.0
39hypertrichosis universalis congenita10.0
40mucopolysaccharidosis ih10.0
41amaurosis - hypertrichosis10.0
42cutaneous porphyria10.0UROS, UROD
43papilledema10.0IGLV1-40, IGLV1-44
44variegate porphyria10.0UROD, PPOX
45hereditary coproporphyria10.0UROS, UROD, PPOX
46acute porphyria10.0PPOX, UROD
47acute intermittent porphyria10.0PPOX, UROD
48erythropoietic protoporphyria10.0UROS, PPOX
49metabolic syndrome x10.0UROS, PPOX, UROD
50congenital hypothyroidism9.9

Graphical network of the top 20 diseases related to Hypertrichosis:



Diseases related to hypertrichosis

Clinical Features for Hypertrichosis

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Drugs & Therapeutics for Hypertrichosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Hypertrichosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypertrichosis

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20GeneTests, 22GTR
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Genetic tests related to Hypertrichosis:

id Genetic test Affiliating Genes
1 Hypertrichosis20 22

Anatomical Context for Hypertrichosis

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32MalaCards
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MalaCards organs/tissues related to Hypertrichosis:

32
Skin, Pituitary, Brain, Colon, Kidney, Ovary, T cells, Prostate, Breast, Thyroid, Lung, Smooth muscle, Eye

Animal Models for Hypertrichosis or affiliated genes

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Publications for Hypertrichosis

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50PubMed
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Articles related to Hypertrichosis:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
Nevoid hypertrichosis, diffuse lipoatrophy and epidermal nevus: a new syndrome? (23452296)
2014
2
Hypomelanosis of Ito and multiple naevoid hypertrichosis: Rare cutaneous mosaicism. (23425222)
2013
3
Intense pulsed light hair removal in a patient with congenital hypertrichosis terminalis. (21575051)
2012
4
Inner canthus hypertrichosis: a side effect of prostaglandin analogue treatment for glaucoma. (21962192)
2011
5
Fibromatosis colli with hypertrichosis: a rare case of cutaneous manifestation of a muscular disorder. (20807360)
2010
6
Congenital hypertrichosis lanuginosa. (21079317)
2010
7
A case of trichomegaly of the eyelashes and facial hypertrichosis induced by erlotinib (Tarceva). (19126063)
2009
8
Hypertrichosis in three patients treated with interferon-alpha2. (19663862)
2009
9
Case of pigmented neurofibroma with hypertrichosis with no association to neurofibromatosis. (19785708)
2009
10
Diabetes mellitus, exocrine pancreatic deficiency, hypertrichosis, hyperpigmentation, and chronic inflammation: confirmation of a syndrome. (19175903)
2009
11
SLC29A3 gene is mutated in pigmented hypertrichosis with insulin- dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway. (19336477)
2009
12
Correlation between finger-prick and venous ciclosporin levels: association with gingival overgrowth and hypertrichosis. (17899211)
2007
13
Anterior cervical hypertrichosis and mental retardation. (16760744)
2006
14
Fibrous hamartoma of infancy manifesting as multiple nodules with hypertrichosis. (16700836)
2006
15
Localized hypertrichosis in subsiding psoriatic plaques. (15492447)
2004
16
Acromegaloid facial appearance and hypertrichosis: a case suggesting autosomal recessive inheritance. (15127769)
2004
17
Hypertrichosis. (12582385)
2003
18
Interferon alpha and hypertrichosis of eyelashes. (12150190)
2002
19
Unilateral generalized hypertrichosis in proteus syndrome. (17656984)
2002
20
Eyelash hypertrichosis in a patient treated with topical latanoprost. (11236218)
2001
21
Non-pseudomonal malignant otitis externa and jugular foramen syndrome secondary to cyclosporin-induced hypertrichosis in a diabetic renal transplant patient. (10912267)
2000
22
A patient with congenital hypertrichosis, gum hyperplasia and macromastia. (10803876)
2000
23
The woman beneath the hair: treating hypertrichosis, 1870-1930. (19530370)
2000
24
A sporadic form of hypertrichosis cubiti. (10681173)
1999
25
Elective conversion of patients from cyclosporine to tacrolimus for hypertrichosis. (9636505)
1998
26
Conversion from Neoral (cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. (9636507)
1998
27
Rectal cancer associated with acquired hypertrichosis lanuginosa as a possible cutaneous marker of internal malignancy. (9719246)
1998
28
Hypertrichosis cubiti: a case in a Sri Lankan family. (9159015)
1997
29
An autosomal dominant syndrome of acromegaloid facial appearance and generalised hypertrichosis terminalis. (8950682)
1996
30
Mapping of the congenital generalized hypertrichosis locus to chromosome Xq24-q27.1. (7663516)
1995
31
Ipsilateral post-cast hypertrichosis and dyshidrotic dermatitis. (7811183)
1995
32
Acquired hypertrichosis lanuginosa and polymyositis. (8444541)
1993
33
Anterior cervical hypertrichosis versus hairy throat. (8281287)
1993
34
Hypertrichosis in mentally ill women. (1521127)
1992
35
Cataract, hypertrichosis, and mental retardation (CAHMR): a new autosomal recessive syndrome. (1776632)
1991
36
Hypertrichosis and verapamil. (1682630)
1991
37
Bioactive and peripheral androgens in prepubertal simple hypertrichosis. (2147601)
1990
38
Naevoid hypertrichosis--report of a patient with multiple lesions. (2805390)
1989
39
Localized acquired hypertrichosis associated with fracture and cast application. (2724357)
1989
40
Postphlebitic localized hypertrichosis. (3337545)
1988
41
Congenital hypertrichosis lanuginosa: neonatal shaving. (3619483)
1987
42
Hypertrichosis and congenital anomalies associated with maternal use of minoxidil. (3547299)
1987
43
In tema di hypertrichosis universalis congenita: contributo storico-medico. (11611846)
1983
44
Hypertrichosis and multiple cutaneous squamous cell carcinomas in association with cyclosporin A therapy. (6620282)
1983
45
Lack of a gonadal or adrenal androgenic mechanism for the hypertrichosis produced by diazoxide, phenytoin and minoxidil. (7104030)
1982
46
Acquired localized hypertrichosis. (7212723)
1981
47
Osteosclerotic "plasmocytoma" with polyneuropathy, hypertrichosis and diabetes. (645443)
1978
48
The tricho system: hypertrichosis, radiation, and cancer. (778495)
1976
49
Familial hypertrichosis cubiti: hairy elbows syndrome. (5519603)
1970
50
A contribution to the genetics of hypertrichosis of the ear rims. (13746524)
1961

Genetic Variations for Hypertrichosis

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Expression for genes affiliated with Hypertrichosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrichosis

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Pathways for genes affiliated with Hypertrichosis

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Hypertrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PPOX, UROD, UROS
2
Hide members
10.1PPOX, UROD, UROS

Compounds for genes affiliated with Hypertrichosis

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Hypertrichosis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1uroporphyrinogen i44 2411.4UROS, UROD
2hydroxymethylbilane44 2411.4PPOX, UROD, UROS
3uroporphyrinogen-iii4410.4PPOX, UROD, UROS
4formyl-coa44 2411.3UROS, UROD, PPOX
5uroporphyrin i4410.3UROD, UROS
6porphyrin4410.3PPOX, UROD, UROS
7porphobilinogen44 11 2412.3PPOX, UROD, UROS
8uroporphyrin4410.3UROS, UROD
95-aminolevulinic acid44 2411.3PPOX, UROD, UROS
10protoporphyrinogen4410.2UROD, PPOX
11protoporphyrin ix44 11 2412.1PPOX, UROD
12heme28 11 2412.1PPOX, UROD, UROS
13haem449.9PPOX, UROD

GO Terms for genes affiliated with Hypertrichosis

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16Gene Ontology
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Biological processes related to Hypertrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme biosynthetic processGO:00678310.1PPOX, UROD, UROS
2protoporphyrinogen IX biosynthetic processGO:00678210.0PPOX, UROD, UROS
3porphyrin-containing compound metabolic processGO:0067789.8PPOX, UROD, UROS

Products for genes affiliated with Hypertrichosis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Hypertrichosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet