MCID: HYP077
MIFTS: 51

Hypertrichosis malady

Skin diseases category

Summaries for Hypertrichosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertrichosis (also called Ambras syndrome) is an abnormal amount of hair growth over the body;... more...

MalaCards: Hypertrichosis, also known as hypertrichosis nos, is related to porphyria and porphyria cutanea tarda. An important gene associated with Hypertrichosis is SLC29A3 (solute carrier family 29 (equilibrative nucleoside transporter), member 3), and among its related pathways are Glucuronidation and Heme Biosynthesis. The drugs eflornithine and eflornithine hydrochloride and the compounds uroporphyrinogen i and hydroxymethylbilane have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and brain.

Aliases & Classifications for Hypertrichosis

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8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hypertrichosis 8 20 22 10 60
hypertrichosis nos 8


External Ids:

Disease Ontology8 DOID:420
NCIt39 C79597
MeSH34 D006983
ICD1025 L68, L68.9

Related Diseases for Hypertrichosis

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17GeneCards, 18GeneDecks
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Diseases related to Hypertrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 214)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria30.2PPOX, UROD
2porphyria cutanea tarda30.1PPOX, UROD, UROS
3poems syndrome29.9IGLV1-44, IGLV1-40
4hepatoerythropoietic porphyria29.6UROD, UROS
5congenital porphyria29.6UROS, UROD
6gingivitis10.5
7gingival fibromatosis with hypertrichosis10.4
8cervicitis10.3
9hypertrichosis lanuginosa congenita10.3
10ambras syndrome10.3
11cervical hypertrichosis peripheral neuropathy10.2
12hypertrichosis lanuginosa, acquired10.2
13osteochondrodysplasia10.2
14hypertrichosis congenital generalized x-linked10.2
15adenocarcinoma10.2
16hypothyroidism10.2
17barber say syndrome10.2
18cantu syndrome10.2
19isolated anterior cervical hypertrichosis10.2
20acromegaloid hypertrichosis syndrome10.1
21hypertrichosis cubiti - short stature10.1
22dermatomyositis10.1
23glaucoma10.1
24hypertrichosis, anterior cervical10.1
25histiocytosis-lymphadenopathy plus syndrome10.1
26congenital generalized hypertrichosis, ambras type10.1
27cataract - hypertrichosis - intellectual deficit10.1
28cerebritis10.0
29hypertrichosis of eyelid10.0
30alopecia10.0
31diabetes mellitus10.0
32ectropion10.0
33neurofibroma10.0
34panniculitis10.0
35polyneuropathy10.0
36scleroderma10.0
37amaurosis congenita cone-rod type with congenital hypertrichosis10.0
38cahmr syndrome10.0
39hypertrichosis universalis congenita10.0
40mucopolysaccharidosis ih10.0
41amaurosis - hypertrichosis10.0
42cutaneous porphyria10.0UROS, UROD
43papilledema10.0IGLV1-40, IGLV1-44
44variegate porphyria10.0UROD, PPOX
45hereditary coproporphyria10.0UROS, UROD, PPOX
46acute porphyria10.0PPOX, UROD
47acute intermittent porphyria10.0PPOX, UROD
48erythropoietic protoporphyria10.0UROS, PPOX
49metabolic syndrome x10.0UROS, PPOX, UROD
50congenital hypothyroidism9.9

Graphical network of the top 20 diseases related to Hypertrichosis:



Diseases related to hypertrichosis

Clinical Features for Hypertrichosis

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Drugs & Therapeutics for Hypertrichosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Hypertrichosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypertrichosis

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20GeneTests, 22GTR
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Genetic tests related to Hypertrichosis:

id Genetic test Affiliating Genes
1 Hypertrichosis20 22

Anatomical Context for Hypertrichosis

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32MalaCards
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MalaCards organs/tissues related to Hypertrichosis:

32
Skin, Pituitary, Brain, Colon, Kidney, Ovary, T cells, Prostate, Breast, Thyroid, Lung, Smooth muscle, Eye

Animal Models for Hypertrichosis or affiliated genes

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Publications for Hypertrichosis

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Sources:
50PubMed
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Articles related to Hypertrichosis:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
Hypertrichosis in Becker's nevus: effective low-fluence laser hair removal. (23558435)
2014
2
Acquired localized hypertrichosis induced by internal fixation and plaster cast application. (24003283)
2013
3
Localized hypertrichosis overlying neurofibroma. (22320442)
2013
4
Nevoid hypertrichosis of the face in a 3-month-old girl with Aicardi syndrome. (23985081)
2013
5
Hypertrichosis after surgery for cubital tunnel syndrome. (21240491)
2012
6
High frequency of hypertrichosis after cast application. (22907098)
2012
7
Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. (23133399)
2012
8
Hypertrichosis around a leg ulcer being treated with prostaglandin E1 ointment. (21571200)
2011
9
Localized hypertrichosis after sclerotherapy. (20590714)
2010
10
Familial anterior cervical hypertrichosis. (20827011)
2010
11
Facial hypertrichosis and trichomegaly developing in patients treated with the epidermal growth factor receptor inhibitor erlotinib. (20633793)
2010
12
Congenital plaque-like glomangioma associated with superficial hypertrichosis. (18489057)
2008
13
Acquired hypertrichosis lanuginosa: a rare cutaneous paraneoplastic syndrome. (17443005)
2007
14
Acquired hypertrichosis lanuginosa as a presenting sign of metastatic prostate cancer with rapid resolution after treatment. (17224383)
2007
15
An unusual cause of hypertrichosis. (17293640)
2007
16
Transient hypertrichosis in a patient with Guillain-BarrAc syndrome. (18042141)
2007
17
Acquired eyelash trichomegaly and generalized hypertrichosis associated with breast anomaly. (16638412)
2006
18
Post-surgical hypertrichosis. (16996443)
2006
19
Hypertrichosis cubiti (hairy elbow syndrome): a clue to a malformation syndrome. (16355816)
2005
20
Hypertrichosis surrounding scar of knee replacement surgery. (15097975)
2004
21
Acquired trichomegaly of the eyelashes and hypertrichosis induced by bimatoprost. (15324422)
2004
22
Localized acquired hypertrichosis following cast application. (11207975)
2001
23
Primary generalized and localized hypertrichosis in children. (11453806)
2001
24
Congenital hypertrichosis, osteochondrodysplasia, and cardiomegaly: CantA_ syndrome. (10398267)
1999
25
Shaving: a simple and effective treatment for moderate congenital hypertrichosis. (9649679)
1998
26
Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in the region of the ipsilateral eyelids of patients treated with unilateral topical latanoprost. (9323945)
1997
27
Spironolactone therapy in hypertrichosis. (8980164)
1996
28
Hydrocephalus and hypertrichosis in Golden Retriever dogs. (16031891)
1996
29
Localized hypertrichosis associated with periorbital neurofibroma: clinical findings and differential diagnosis. (8643252)
1996
30
Hypertrichosis as the presenting feature of porphyria cutanea tarda. (7671402)
1995
31
Acquired circumscribed hypertrichosis in the 'costaleros' who bear the 'pasos' during Holy Week in Seville, Spain. (7887676)
1995
32
Severe hypertrichosis as an uncommon feature of juvenile dermatomyositis. (7673511)
1995
33
Acquired trichomegaly and hypertrichosis in metastatic adenocarcinoma. (7671421)
1995
34
Hypertrichosis "cubiti" with facial asymmetry. (7802037)
1994
35
Macrostomia, ectropion, atrophic skin, hypertrichosis: another observation. (1867254)
1991
36
Drug-induced hypertrichosis: case report and review of the literature. (2183489)
1990
37
Pituitary enlargement, hypertrichosis and blunted growth hormone secretion in primary hypothyroidism. (2919516)
1989
38
Ciclosporin-associated hypertrichosis is not related to sex hormone levels following renal transplantation. (3067101)
1988
39
Acquired hypertrichosis lanuginosa. (640103)
1978
40
Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory. (850811)
1977
41
Acquired hypertrichosis lanuginosa associated with endometrial malignancy. (1256731)
1976
42
Acquired hypertrichosis lanuginosa and malignancy. A clinical review and histopathologic evaluation with special attention to the "mantle" hair of Pinkus. (4339024)
1972
43
Hypertrichosis of the Cornelia de Lange syndrome. (5173275)
1971
44
Hypertrichosis lanuginosa as a sign of internal malignancy. (5353938)
1969
45
"Hypertrichosis pinnae auris" in Malaysian peoples. (4237562)
1968
46
Recurrent peptic ulcers with general hypertrichosis including growth of hair on the bald scalp and later development of signs suggesting adrenal failure. (14834171)
1951
47
Hypertrichosis in childhood; a clinical study. (14818807)
1951
48
Congenital porphyria, hydroa aestivale and hypertrichosis in a South African Bantu. (14795725)
1950
49
Hypertrichosis. (18874059)
1948
50
Spina Bifida Occulta with Hypertrichosis. (19988776)
1932

Genetic Variations for Hypertrichosis

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Expression for genes affiliated with Hypertrichosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrichosis

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Pathways for genes affiliated with Hypertrichosis

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Hypertrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PPOX, UROD, UROS
2
Hide members
10.1PPOX, UROD, UROS

Compounds for genes affiliated with Hypertrichosis

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Hypertrichosis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1uroporphyrinogen i44 2411.4UROS, UROD
2hydroxymethylbilane44 2411.4PPOX, UROD, UROS
3uroporphyrinogen-iii4410.4PPOX, UROD, UROS
4formyl-coa44 2411.3UROS, UROD, PPOX
5uroporphyrin i4410.3UROD, UROS
6porphyrin4410.3PPOX, UROD, UROS
7porphobilinogen44 11 2412.3PPOX, UROD, UROS
8uroporphyrin4410.3UROS, UROD
95-aminolevulinic acid44 2411.3PPOX, UROD, UROS
10protoporphyrinogen4410.2UROD, PPOX
11protoporphyrin ix44 11 2412.1PPOX, UROD
12heme28 11 2412.1PPOX, UROD, UROS
13haem449.9PPOX, UROD

GO Terms for genes affiliated with Hypertrichosis

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16Gene Ontology
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Biological processes related to Hypertrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme biosynthetic processGO:00678310.1PPOX, UROD, UROS
2protoporphyrinogen IX biosynthetic processGO:00678210.0PPOX, UROD, UROS
3porphyrin-containing compound metabolic processGO:0067789.8PPOX, UROD, UROS

Products for genes affiliated with Hypertrichosis

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  • Antibodies
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Sources for Hypertrichosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet