MCID: HYP117
MIFTS: 67

Hypertriglyceridemia malady

Genetic diseases, Metabolic diseases, Endocrine diseases, Rare diseases categories
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Summaries for Hypertriglyceridemia

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Wikipedia:65 Hypertriglyceridemia denotes high (hyper-) blood levels (-emia) of triglycerides, the most abundant... more...

MalaCards based summary: Hypertriglyceridemia, also known as hyperlipoproteinemia type 4, is related to familial hypertriglyceridemia and familial combined hyperlipidemia, and has symptoms including An important gene associated with Hypertriglyceridemia is APOA5 (apolipoprotein A-V), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Triglyceride Biosynthesis. The compounds fenofibric acid and campesterol have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and liver, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Descriptions from OMIM:46 144600,145750

Aliases & Classifications for Hypertriglyceridemia

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Sources:
46OMIM, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Hypertriglyceridemia, Aliases & Descriptions:

Name: Hypertriglyceridemia 46 44
Hyperlipoproteinemia Type 4 48 46
 
Familial Hypertriglyceridaemia 62
Familial Hypertriglyceridemia 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
hyperlipoproteinemia type 4:
Inheritance: Autosomal dominant; Age of onset: Adulthood


External Ids:

MESH via Orphanet35 D006953
ICD10 via Orphanet26 E78.1
UMLS via Orphanet63 C0020480

Related Diseases for Hypertriglyceridemia

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Diseases in the Hypertriglyceridemia family:

Familial Hypertriglyceridemia

Diseases related to Hypertriglyceridemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1familial hypertriglyceridemia31.5SLC10A2, LPL, APOB, APOC3
2familial combined hyperlipidemia30.7APOE, APOA1, APOB, HMGCR
3fish-eye disease30.5APOA1, APOA2
4hypertension30.4APOE, APOA1, APOB, LPA, LPL
5hypothyroidism30.1APOB, LDLR, CETP, LPA
6lipodystrophy30.0APOC3, APOB, LDLR, LPL, HMGCR
7glucose intolerance29.9APOA1, APOC2, APOB, PON1, CETP, LPL
8hyperhomocysteinemia29.9APOE, PON1, LPA
9familial hypercholesterolemia29.9APOB, LDLR, CETP, HMGCR
10hypoalphalipoproteinemia29.9CETP, LDLR, APOB, APOA2, APOC3, APOA1
11hyperglycemia29.8APOB, PON1, CETP, LPA, LPL, HMGCR
12hyperalphalipoproteinemia29.6CETP, LDLR, APOB, APOA2, APOC3, APOA1
13uremia29.6LPL, LPA, LDLR, PON1, APOC3
14insulin resistance29.6HMGCR, LPL, LPA, CETP, LDLR, PON1
15obesity29.6APOE, GPD1, APOA1, LPL, LPA, CETP
16hyperinsulinism29.5APOA1, APOA2, APOB, LDLR, CETP, LPL
17fatty liver disease29.5APOA1, APOC3, APOB, CETP, LPL, HMGCR
18tangier disease29.3APOA2, APOC3, APOA1, APOE, APOB, LPL
19diabetic nephropathy29.2APOE, APOA1, APOB, PON1, LPA, HMGCR
20diabetes mellitus29.2HMGCR, APOE, APOA1, LPL, LPA, CETP
21hyperlipidemia type 329.2APOB, APOA5, APOA1, APOE, LDLR, CETP
22proteinuria29.1APOA1, APOC3, APOA2, APOC2, APOB, CETP
23hypercholesterolemia28.9APOC2, APOA2, APOC3, APOA1, APOE, APOB
24nephrotic syndrome28.9HMGCR, LPL, LPA, CETP, PON1, APOB
25type 2 diabetes mellitus28.7APOA1, APOE, APOC3, APOA2, APOC2, HMGCR
26vascular disease28.7APOB, APOC2, APOA1, APOE, PON1, LDLR
27myocardial infarction28.3APOA5, APOC3, APOA1, APOE, APOA2, APOB
28atherosclerosis28.0SLC10A2, HMGCR, LPL, LPA, CETP, LDLR
29familial hyperlipidemia28.0HMGCR, LPL, LPA, CETP, LDLR, PON1
30pancreatitis10.8
31acute pancreatitis10.7
32steatorrhea10.5SLC10A2
33hepatitis10.5
34lipoprotein glomerulopathy10.5APOE
35cerebral atherosclerosis10.5APOA1
36chylomicron retention disease10.4APOB
37endotheliitis10.4
38arcus senilis10.4APOA1, APOB
39leukemia10.4
40hyperlipoproteinemia type v10.3APOE, APOC2, LPL
41hyperlipoproteinemia type iv10.3
42age related macular degeneration10.3APOE, APOB
43acute lymphoblastic leukemia10.3
44lymphoblastic leukemia10.3
45hypertriglyceridemia, transient infantile10.3
46amyloidosis, renal10.3APOA1, APOA2
47carotid artery disease10.3APOB, PON1
48sitosterolemia10.2HMGCR
49artery disease10.2
50pancreatitis, chronic10.2LPL, APOB, APOC2

Graphical network of the top 20 diseases related to Hypertriglyceridemia:



Diseases related to hypertriglyceridemia

Symptoms for Hypertriglyceridemia

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Symptoms by clinical synopsis from OMIM:

144600

Clinical features from OMIM:

144600,145750

HPO human phenotypes related to Hypertriglyceridemia:

(show all 13)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 atheroeruptive xanthoma HP:0001039
3 heterogeneous HP:0001425
4 abnormal glucose tolerance HP:0001952
5 hypertriglyceridemia HP:0002155
6 increased circulating very-low-density lipoprotein cholesterol HP:0003362
7 precocious atherosclerosis HP:0004416
8 autosomal dominant inheritance HP:0000006
9 atheroeruptive xanthoma HP:0001039
10 abnormal glucose tolerance HP:0001952
11 hypertriglyceridemia HP:0002155
12 increased circulating very-low-density lipoprotein cholesterol HP:0003362
13 precocious atherosclerosis HP:0004416

Drugs & Therapeutics for Hypertriglyceridemia

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Drug clinical trials:

Search ClinicalTrials for Hypertriglyceridemia

Search NIH Clinical Center for Hypertriglyceridemia

Genetic Tests for Hypertriglyceridemia

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Anatomical Context for Hypertriglyceridemia

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MalaCards organs/tissues related to Hypertriglyceridemia:

32
Heart, Skin, Liver, Endothelial, Monocytes, Kidney, Lung, Breast, Prostate, Bone, Whole blood, Brain, Adipocyte

Animal Models for Hypertriglyceridemia or affiliated genes

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MGI Mouse Phenotypes related to Hypertriglyceridemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3APOE, APOA1, APOB, LIPI, LDLR, LPL
2MP:00053858.1APOA1, APOC3, APOB, PON1, LDLR, LPL
3MP:00053787.7GPD1, APOE, APOC3, APOA2, APOB, LIPI
4MP:00053767.0SLC10A2, GPD1, APOE, APOA1, APOC3, APOA5

Publications for Hypertriglyceridemia

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Articles related to Hypertriglyceridemia:

(show top 50)    (show all 785)
idTitleAuthorsYear
1
Impact of hypertriglyceridemia on the outcome of acute biliary pancreatitis. (25171545)
2014
2
Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291). (25127531)
2014
3
Hypertriglyceridemia, lipemia, and elevated liver enzymes associated with prolonged propofol anesthesia for craniotomy. (25222854)
2014
4
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. (23836343)
2013
5
Effect of green tea extract microencapsulation on hypertriglyceridemia and cardiovascular tissues in high fructose-fed rats. (24133615)
2013
6
Metabolic surgery for the treatment of hypertriglyceridemia-related pancreatitis due to familial lipoprotein lipase deficiency. (24680758)
2013
7
Primary Hypertriglyceridemia type IV : severe incidentaloma of early presentation. (24343502)
2013
8
Effects of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on hyperinsulinemia and hypertriglyceridemia in prediabetic Zucker fatty rats. (23917858)
2013
9
What should we do about Hypertriglyceridemia in Coronary Artery Disease Patients? (23109123)
2013
10
Salacia oblonga ameliorates hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. (22561158)
2012
11
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. (22135386)
2012
12
Management of hypertriglyceridemia in children with acute lymphoblastic leukemia under persistent therapy with glucocorticoids and L-asparaginase during induction chemotherapy. (22619026)
2012
13
Successful management of extreme hypertriglyceridemia from pegaspargase with omega-3. (22392609)
2012
14
Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. (22962670)
2012
15
Hypertriglyceridemia secondary to obesity and diabetes. (22005032)
2012
16
Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption. (21604764)
2011
17
Etiology and risk of lactescent plasma and severe hypertriglyceridemia. (21262505)
2011
18
The relative importance of common and rare genetic variants in the development of hypertriglyceridemia. (21615327)
2011
19
Patient characteristics and medical care costs associated with hypertriglyceridemia. (21211599)
2011
20
Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy. (21150557)
2011
21
Management of hypertriglyceridemia in the diabetic patient. (20532703)
2010
22
Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype. (20368524)
2010
23
Sirolimus-induced severe hypertriglyceridemia in a lung transplant recipient. (20177353)
2010
24
Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice. (19362162)
2009
25
Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. (19667310)
2009
26
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
27
Acute elevation of triglycerides after initiation of fosamprinavir/ritonavir in an HIV-negative patient with baseline hypertriglyceridemia. (21291769)
2008
28
Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver. (18357405)
2008
29
Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia. (17196967)
2008
30
Examination of the skin in hypertriglyceridemia. (18595869)
2008
31
Treating hypertriglyceridemia. (17846443)
2007
32
The role of hypertriglyceridemia in atherosclerosis. (17877919)
2007
33
Hypertriglyceridemia and cardiovascular risk reduction. (17697898)
2007
34
Hypertriglyceridemia and cardiovascular disease management. (18510282)
2007
35
Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia. (16940448)
2006
36
Priapism secondary to hypertriglyceridemia. (12576856)
2003
37
Insulin resistance but not hypertriglyceridemia per se is associated with endothelial dysfunction in chronic hypertriglyceridemia. (11827701)
2002
38
Apolipoprotein E1 Baden (Arg(180)-->Cys). A new apolipoprotein E variant associated with hypertriglyceridemia. (11163021)
2001
39
Lipoprotein lipase gene polymorphism and lipid profile in patients with hypertriglyceridemia. (11593500)
2001
40
Identification and treatment of hypertriglyceridemia as a risk factor for coronary heart disease. (10980847)
1999
41
Tumor necrosis factor alpha as a uremic toxin: correlation with neuropathy, left ventricular hypertrophy, anemia, and hypertriglyceridemia in peritoneal dialysis patients. (10682077)
1999
42
Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. (10606208)
1999
43
The TNF-beta gene Nco I polymorphism is not associated with hypertriglyceridemia or insulin resistance in lean and obese subjects. (9245742)
1997
44
Relationship of plasma cholesteryl ester transfer protein to HDL cholesterol. Studies in normotriglyceridemia and moderate hypertriglyceridemia. (8977446)
1996
45
Primary chylomicronemia in patients with severe familial hypertriglyceridemia responds to long-term treatment with (n-3) fatty acids. (7782902)
1995
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia. (8349676)
1993
48
Does familial hypertriglyceridemia predispose to NIDDM? (8299439)
1993
49
Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology and clinical course of hypertension. (1994722)
1991
50
Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. (1752964)
1991

Variations for Hypertriglyceridemia

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Expression for genes affiliated with Hypertriglyceridemia

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Expression patterns in normal tissues for genes affiliated with Hypertriglyceridemia

Search GEO for disease gene expression data for Hypertriglyceridemia.

Pathways for genes affiliated with Hypertriglyceridemia

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Pathways related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8APOA2, APOA1
2
Show member pathways
9.8LPIN2, LPIN3, GPD1
3
Show member pathways
9.7LPIN3, LPL, LPIN2
49.7LPIN3, LPL, LPIN2
5
Show member pathways
9.6APOB, APOA1, APOE
69.4HMGCR, LDLR
7
Show member pathways
thioredoxin pathway37
9.4LDLR, APOB, APOA1
8
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.2APOA1, APOC3, APOA5, APOA2, LPL
99.2LDLR, HMGCR, SLC10A2
10
Show member pathways
9.1HMGCR, LPL, LDLR
119.1APOA1, APOA2, APOB, LPA
12
Show member pathways
8.1APOE, APOA1, APOC3, APOA2, APOC2, APOB
138.1APOE, APOA1, APOC3, APOA2, APOC2, APOB
14
Show member pathways
8.1APOE, APOA1, APOC3, APOA2, APOC2, APOB
15
Show member pathways
8.0GPD1, APOA1, APOA5, APOA2, LPIN3, LPL
16
Show member pathways
7.1APOB, APOC2, APOA2, APOA5, APOC3, APOA1
17
Show member pathways
6.9APOE, HMGCR, LPL, CETP, LDLR, APOB
18
Show member pathways
5.0LDLR, CETP, LPA, LPIN3, LPL, LPIN2

Compounds for genes affiliated with Hypertriglyceridemia

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Compounds related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1fenofibric acid44 2810.1APOC3, APOB, LPL, HMGCR, APOA1
2campesterol44 2410.1HMGCR, APOE, APOA1, APOB
3psyllium449.0APOB, LDLR, CETP, HMGCR
4xbai448.9CETP, LPL, LDLR, APOB, APOC3, APOE
5dimyristoylphosphatidylcholine448.9LPA, APOA1, APOA2, APOA5, LDLR, APOE
6taurocholate448.9SLC10A2, APOA1, APOC3, APOB, LPL, HMGCR
7intralipid448.8APOA1, APOC3, APOA2, APOB, CETP, LPL
8tocopherol448.8LDLR, APOB, APOA1, HMGCR, LPL
9sele448.7LDLR, LPL, CETP, PON1, APOC3, APOE
10lathosterol44 249.7HMGCR, APOE, LDLR, APOB, CETP
117-ketocholesterol44 249.7APOE, APOA1, HMGCR, PON1, APOB
12oleic acid44 28 24 1111.7CETP, LPA, GPD1, LPL, LDLR, APOB
13ritonavir44 50 1110.6APOC3, LPL, HMGCR, LDLR, APOE
14ezetimibe44 119.6HMGCR, APOB, CETP, LDLR, APOA1
15rosiglitazone28 44 50 24 1112.6LPL, PON1, APOB, APOC3, APOE, GPD1
16palmitate448.5LPL, CETP, LDLR, APOB, APOA1, APOE
17mspi448.5APOA1, APOC3, APOA2, APOB, LDLR, CETP
18ursodeoxycholic acid44 24 1110.5LDLR, SLC10A2, LPA, HMGCR, APOE
19rosuvastatin44 50 28 1111.4APOC3, APOB, LDLR, CETP, HMGCR, APOE
20ciprofibrate44 289.4HMGCR, LPL, LDLR, APOB, APOA1, PON1
21probucol44 119.3APOE, APOA1, APOB, LDLR, CETP, LPL
22cholestyramine448.2APOB, LDLR, CETP, LPA, HMGCR, APOC3
23homocysteine44 249.2APOE, APOA1, LPA, APOC2, CETP, APOB
24sterol448.2SLC10A2, HMGCR, APOB, APOA1, APOE, CETP
25niacin44 119.1APOB, LPA, LPL, LDLR, APOA1, HMGCR
26fatty acid447.8LPL, LPA, APOC2, APOB, CETP, GPD1
27fluvastatin44 50 28 1110.8APOB, PON1, LDLR, CETP, LPL, HMGCR
28triacylglycerol447.8CETP, LPL, LDLR, APOB, APOC2, GPD1
29testosterone44 61 24 1110.7APOA1, GPD1, PON1, APOE, APOB, CETP
30alpha tocopherol447.7CETP, PON1, APOA1, APOE, LDLR, APOB
31glucose447.6APOA5, APOC2, APOA2, PON1, APOC3, APOA1
32phospholipid447.6CETP, APOA1, APOE, APOC3, APOA2, APOC2
33phosphatidylcholine447.6APOE, LPL, LPA, CETP, LDLR, PON1
34vitamin a44 24 119.5LPA, CETP, LDLR, PON1, APOB, APOC2
35aspirin44 50 28 2410.5LDLR, APOA1, APOE, APOB, PON1, CETP
36creatinine447.5HMGCR, PON1, LPA, APOE, APOB, APOC2
37thyroxine44 248.3CETP, APOE, HMGCR, LPL, LPA, LDLR
38bezafibrate44 28 119.3APOE, APOA1, APOC3, APOA2, APOB, LDLR
39simvastatin44 50 61 28 24 1112.2APOE, APOA1, APOA5, APOB, PON1, LDLR
40estrogen447.2LDLR, CETP, LPL, PON1, APOB, APOA2
41lovastatin44 50 61 28 1111.0APOE, APOA1, APOC3, APOA5, APOB, PON1
42pravastatin44 50 28 24 1110.9APOE, APOA1, APOC3, APOB, PON1, LDLR
43cholesterol ester446.8HMGCR, APOE, APOA1, APOC3, APOA2, APOB
44atorvastatin44 50 28 24 1110.7APOE, APOA1, APOC3, APOA5, APOB, PON1
45heparin44 28 24 119.7PON1, APOE, APOC3, APOA5, APOA2, APOC2
46fenofibrate44 50 118.6LPL, HMGCR, LPA, CETP, LDLR, APOE
47gemfibrozil28 44 118.6HMGCR, APOE, APOA1, APOC3, APOA2, APOC2
48serine446.3APOC2, PON1, SLC10A2, HMGCR, CETP, LDLR
49cholesterol44 28 24 118.3APOC3, SLC10A2, HMGCR, APOA5, APOA2, APOC2
50lipid445.1LPL, LPA, CETP, LDLR, PON1, APOB

GO Terms for genes affiliated with Hypertriglyceridemia

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Cellular components related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:0343639.5APOB, APOC3, APOE, APOC2
2endocytic vesicle lumenGO:0716829.3APOE, APOA1, APOB
3low-density lipoprotein particleGO:0343629.2LDLR, APOC2, APOA5, APOE, APOB
4spherical high-density lipoprotein particleGO:0343669.1APOA1, APOC3, APOC2, APOA2, PON1
5blood microparticleGO:0725629.0PON1, APOA2, APOA1, APOE
6chylomicronGO:0426278.9APOE, APOC3, APOA2, APOA5, LPL, APOB
7high-density lipoprotein particleGO:0343648.7CETP, PON1, APOA2, APOA5, APOA1, APOE
8very-low-density lipoprotein particleGO:0343618.6APOB, LPL, APOA2, APOA1, APOA5, APOC3
9early endosomeGO:0057698.4APOA1, LDLR, APOB, APOC2, APOA2, APOC3
10extracellular spaceGO:0056157.5LPL, APOE, APOA1, APOC3, APOA5, APOC2
11extracellular regionGO:0055767.0APOA5, APOA1, PON1, CETP, LPA, LIPI

Biological processes related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of very-low-density lipoprotein particle remodelingGO:01090210.4APOA5, APOC2
2negative regulation of lipid metabolic processGO:04583310.3APOC2, APOC3
3chylomicron remodelingGO:03437110.3APOC2, LPL
4negative regulation of cholesterol importGO:06062110.3APOC3, APOA2
5negative regulation of very-low-density lipoprotein particle clearanceGO:01091610.3APOC2, APOC3
6negative regulation of cholesterol transportGO:03237510.2APOA2, APOC2
7negative regulation of lipase activityGO:06019210.1APOA1, APOA2
8chylomicron remnant clearanceGO:03438210.1APOE, APOC2, APOC3
9triglyceride-rich lipoprotein particle remodelingGO:03437010.1APOA2, APOA5, APOC2
10triglyceride mobilizationGO:00664210.1APOB, APOC3
11lipoprotein transportGO:04295310.1APOC3, APOC2, APOB
12regulation of Cdc42 protein signal transductionGO:03248910.1APOC3, APOE, APOA1
13negative regulation of receptor-mediated endocytosisGO:04826110.1APOC2, APOC3
14regulation of intestinal cholesterol absorptionGO:03030010.1APOA2, APOA1
15negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.0APOA1, APOA2, APOC3
16cholesterol importGO:07050810.0LDLR, APOA1
17positive regulation of lipid catabolic processGO:05099610.0APOA5, APOA2
18triglyceride biosynthetic processGO:01943210.0LPIN2, GPD1, LPL
19lipoprotein biosynthetic processGO:0421589.9APOA1, APOB, APOE
20negative regulation of cytokine secretion involved in immune responseGO:0027409.9APOA2, APOA1
21organ regenerationGO:0311009.9APOA5, APOA2, APOA1
22high-density lipoprotein particle assemblyGO:0343809.9APOE, APOA1, APOA2
23triglyceride catabolic processGO:0194339.9APOC3, APOB, APOA5, LPL
24positive regulation of cholesterol esterificationGO:0108739.9APOE, APOA2, APOA1
25peripheral nervous system axon regenerationGO:0140129.9APOE, APOA1
26phospholipid metabolic processGO:0066449.8LPL, LPIN2, LPIN3, GPD1
27lipoprotein catabolic processGO:0421599.8APOB, APOE, LDLR
28very-low-density lipoprotein particle remodelingGO:0343729.8APOE, APOC2, CETP, LPL
29high-density lipoprotein particle clearanceGO:0343849.8APOE, APOA1, APOA2, APOC2
30protein oxidationGO:0181589.7APOA2, APOA1
31phosphatidylcholine biosynthetic processGO:0066569.7LPIN2, LPIN3, APOA2, APOA1
32lipid transportGO:0068699.7CETP, APOA5, LPA
33low-density lipoprotein particle remodelingGO:0343749.6APOE, CETP, APOB, APOA2
34phospholipid effluxGO:0337009.6APOC3, APOA1, APOC2, APOE, APOA2
35peptidyl-methionine modificationGO:0182069.5APOA1, APOA2
36response to drugGO:0424939.5APOC2, APOC3, APOA2, LPL, APOA1
37cholesterol transportGO:0303019.4APOB, LDLR, CETP, APOA1
38high-density lipoprotein particle remodelingGO:0343759.4APOA2, CETP, APOC3, APOA1, APOE
39triglyceride homeostasisGO:0703289.4APOC3, CETP, APOA1, APOC2, APOA5, LPL
40triglyceride metabolic processGO:0066419.3APOC3, APOA5, CETP, APOE, APOA2, LPL
41cholesterol effluxGO:0333449.2APOA2, APOE, APOC3, APOA1, APOB, APOC2
42reverse cholesterol transportGO:0436919.2APOE, CETP, APOC2, APOA2, APOC3, APOA1
43receptor-mediated endocytosisGO:0068989.0CETP, APOB, LPA, LDLR, APOE
44cellular lipid metabolic processGO:0442559.0LPIN2, APOA5, APOA2, HMGCR, APOA1, GPD1
45cholesterol metabolic processGO:0082038.6CETP, LDLR, APOB, APOA2, APOC3, APOA1
46phototransduction, visible lightGO:0076038.5APOE, APOA1, APOC3, APOA2, APOC2, APOB
47retinoid metabolic processGO:0015238.5APOC2, APOA2, APOC3, APOA1, APOE, APOB
48cholesterol homeostasisGO:0426328.3APOC3, APOA1, APOE, APOA5, APOA2, CETP
49lipoprotein metabolic processGO:0421577.6CETP, LPL, LPA, LDLR, APOB, APOC2
50small molecule metabolic processGO:0442816.0SLC10A2, HMGCR, LPIN2, LPL, LPIN3, APOE

Molecular functions related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein lipase activator activityGO:06023010.2APOC2, APOA5
2lipase bindingGO:03547310.1APOB, APOA5
3triglyceride bindingGO:01712910.0CETP, LPL
4phospholipase activityGO:00462010.0LPL, LIPI
5apolipoprotein receptor bindingGO:03419010.0APOA2, APOA1
6low-density lipoprotein particle receptor bindingGO:05075010.0APOB, APOA5, APOE
7high-density lipoprotein particle receptor bindingGO:0706539.9APOA2, APOC3, APOA1
8phospholipid transporter activityGO:0055489.9APOA1, CETP
9phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.8APOA2, APOA1, APOE
10phosphatidylcholine bindingGO:0312109.8CETP, APOA2, APOA5
11apolipoprotein bindingGO:0341859.8LPL, LPA
12lipase inhibitor activityGO:0551029.7APOC2, APOA2, APOC3, APOA1
13high-density lipoprotein particle bindingGO:0080359.7APOA2, APOA1
14lipid transporter activityGO:0053199.7APOE, APOA2, CETP
15phosphatidate phosphatase activityGO:0081959.7LPIN2, LPIN3
16cholesterol bindingGO:0154859.6APOA1, APOC3, APOA2, CETP
17lipid bindingGO:0082899.4APOE, APOA5, APOA2, APOC2, CETP
18cholesterol transporter activityGO:0171279.2APOE, APOA1, APOA2, APOB, CETP
19heparin bindingGO:0082019.1APOE, APOA5, APOB, LIPI, LPA, LPL
20phospholipid bindingGO:0055438.7PON1, APOB, APOA2, APOA5, APOC3, APOA1
21protein homodimerization activityGO:0428038.5HMGCR, PON1, APOC2, APOA2, APOE, GPD1

Products for genes affiliated with Hypertriglyceridemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hypertriglyceridemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet