MCID: HYP117
MIFTS: 65

Hypertriglyceridemia malady

Genetic diseases, Endocrine diseases, Rare diseases categories

Summaries for Hypertriglyceridemia

About this section
Sources:
66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Hypertriglyceridemia denotes high (hyper-) blood levels (-emia) of triglycerides, the most abundant... more...

MalaCards: Hypertriglyceridemia, also known as hyperlipoproteinemia type 4, is related to familial hypertriglyceridemia and familial combined hyperlipidemia. An important gene associated with Hypertriglyceridemia is APOA5 (apolipoprotein A-V), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Triglyceride Biosynthesis. The compounds fenofibric acid and campesterol have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and liver, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Description from OMIM:48 144600,145750

Aliases & Classifications for Hypertriglyceridemia

About this section
Sources:
50Orphanet, 48OMIM, 46Novoseek, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

50
hyperlipoproteinemia type 4:
Inheritance: Autosomal dominant; Age of onset: Adulthood


Aliases & Descriptions:

hypertriglyceridemia 48 46
hyperlipoproteinemia type 4 50 48
familial hypertriglyceridemia 50


External Ids:

MESH via Orphanet37 D006953
ICD10 via Orphanet27 E78.1
SNOMED-CT via Orphanet60 238085009, 267433009, 34528009
UMLS via Orphanet64 C0020480

Related Diseases for Hypertriglyceridemia

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Hypertriglyceridemia family:

Familial Hypertriglyceridemia

Diseases related to Hypertriglyceridemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1familial hypertriglyceridemia31.2SLC10A2, LPL, APOB, APOC3
2familial combined hyperlipidemia30.6APOA1, APOB, HMGCR, APOE
3obesity30.6LPL, LPA, CETP, LDLR, PON1, APOB
4insulin resistance30.6APOC3, APOA1, HMGCR, LPL, LPA, CETP
5hypertension30.4APOB, LPA, APOE, LPL, APOA1
6diabetes mellitus30.3APOC3, APOA1, APOE, APOA5, APOA2, HMGCR
7hypercholesterolemia30.3APOC2, APOA2, APOC3, APOA1, APOE, APOB
8hyperglycemia30.2HMGCR, LPL, PON1, APOB, CETP, LPA
9hypoalphalipoproteinemia30.1LPL, CETP, LDLR, APOB, APOA2, APOC3
10fish-eye disease30.1APOA2, APOA1
11hypothyroidism30.1LDLR, APOB, LPA, CETP
12lipodystrophy30.1APOC3, HMGCR, LPL, LDLR, APOB
13glucose intolerance30.1APOC2, APOB, PON1, CETP, LPL, APOA1
14coronary artery disease30.1HMGCR, LPL, CETP, LDLR, APOB, APOA1
15type 2 diabetes mellitus30.0HMGCR, LPL, LPA, CETP, LDLR, PON1
16familial hypercholesterolemia30.0APOB, HMGCR, CETP, LDLR
17hyperlipidemia type 329.9APOE, APOA1, HMGCR, LPL, LPA, CETP
18atherosclerosis29.9LDLR, PON1, APOB, APOC2, APOA2, APOA5
19hyperhomocysteinemia29.8APOE, LPA, PON1
20hyperalphalipoproteinemia29.7APOA2, APOB, LDLR, CETP, APOC3, APOA1
21uremia29.7LPL, LPA, PON1, LDLR, APOC3
22fatty liver disease29.7CETP, LPL, APOC3, APOA1, HMGCR, APOB
23vascular disease29.7APOE, PON1, APOA1, APOC2, APOB, LDLR
24tangier disease29.7APOA2, APOC3, APOA1, APOE, APOB, CETP
25diabetic nephropathy29.6APOB, PON1, LPA, HMGCR, APOA1, APOE
26proteinuria29.6LPA, APOC3, APOA2, APOC2, HMGCR, APOB
27nephrotic syndrome29.6HMGCR, LPL, LPA, CETP, APOE, APOA1
28familial hyperlipidemia29.4APOE, APOA1, APOC3, APOA5, APOA2, APOC2
29myocardial infarction29.4HMGCR, LPA, CETP, LDLR, PON1, APOB
30pancreatitis10.8
31acute pancreatitis10.6
32hepatitis10.5
33endotheliitis10.4
34leukemia10.3
35hyperlipoproteinemia type iv10.3
36lymphoblastic leukemia10.3
37hypertriglyceridemia, transient infantile10.3
38artery disease10.2
39diabetic ketoacidosis10.2
40familial lipoprotein lipase deficiency10.2
41recurrent acute pancreatitis10.2
42steatorrhea10.1SLC10A2
43lipoprotein glomerulopathy10.1APOE
44cerebral atherosclerosis10.1APOA1
45chylomicron retention disease10.1APOB
46hyperapobetalipoproteinemia10.1
47blindness10.1
48arcus senilis10.1APOA1, APOB
49hyperlipoproteinemia type v10.1LPL, APOE, APOC2
50age related macular degeneration10.1APOB, APOE

Graphical network of the top 20 diseases related to Hypertriglyceridemia:



Diseases related to hypertriglyceridemia

Symptoms for Hypertriglyceridemia

About this section
Sources:
48OMIM
See all sources

Symptoms by clinical synopsis from OMIM:

144600

Clinical features from OMIM:

144600,145750

Drugs & Therapeutics for Hypertriglyceridemia

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypertriglyceridemia

Drug clinical trials:

Search ClinicalTrials for Hypertriglyceridemia

Search NIH Clinical Center for Hypertriglyceridemia

Search CenterWatch for Hypertriglyceridemia

Genetic Tests for Hypertriglyceridemia

About this section

Anatomical Context for Hypertriglyceridemia

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Hypertriglyceridemia:

34
Heart, Skin, Liver, Endothelial, Monocytes, Kidney, Lung, Breast, Prostate, Adipocyte, Brain, Whole blood, Bone

Animal Models for Hypertriglyceridemia or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Hypertriglyceridemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3APOE, APOA1, APOB, LIPI, LDLR, LPL
2MP:00053858.1APOA1, APOC3, APOB, PON1, LDLR, LPL
3MP:00053787.7GPD1, APOE, APOC3, APOA2, APOB, LIPI
4MP:00053767.0SLC10A2, GPD1, APOE, APOA1, APOC3, APOA5

Publications for Hypertriglyceridemia

About this section
Sources:
53PubMed
See all sources

Articles related to Hypertriglyceridemia:

(show top 50)    (show all 760)
idTitleAuthorsYear
1
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. (23836343)
2013
2
Effect of green tea extract microencapsulation on hypertriglyceridemia and cardiovascular tissues in high fructose-fed rats. (24133615)
2013
3
Primary Hypertriglyceridemia type IV : severe incidentaloma of early presentation. (24343502)
2013
4
Effects of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on hyperinsulinemia and hypertriglyceridemia in prediabetic Zucker fatty rats. (23917858)
2013
5
What should we do about Hypertriglyceridemia in Coronary Artery Disease Patients? (23109123)
2013
6
Salacia oblonga ameliorates hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. (22561158)
2012
7
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. (22135386)
2012
8
Management of hypertriglyceridemia in children with acute lymphoblastic leukemia under persistent therapy with glucocorticoids and L-asparaginase during induction chemotherapy. (22619026)
2012
9
Successful management of extreme hypertriglyceridemia from pegaspargase with omega-3. (22392609)
2012
10
Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. (22962670)
2012
11
Hypertriglyceridemia secondary to obesity and diabetes. (22005032)
2012
12
Hypertriglyceridemia-induced acute pancreatitis treatment with insutin and heparin. (22837949)
2012
13
Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption. (21604764)
2011
14
Etiology and risk of lactescent plasma and severe hypertriglyceridemia. (21262505)
2011
15
The relative importance of common and rare genetic variants in the development of hypertriglyceridemia. (21615327)
2011
16
Patient characteristics and medical care costs associated with hypertriglyceridemia. (21211599)
2011
17
Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy. (21150557)
2011
18
Management of hypertriglyceridemia in the diabetic patient. (20532703)
2010
19
Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype. (20368524)
2010
20
Sirolimus-induced severe hypertriglyceridemia in a lung transplant recipient. (20177353)
2010
21
Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice. (19362162)
2009
22
Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. (19667310)
2009
23
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
24
Fish oil and the management of hypertriglyceridemia. (19326719)
2009
25
Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. (19560954)
2009
26
Acute elevation of triglycerides after initiation of fosamprinavir/ritonavir in an HIV-negative patient with baseline hypertriglyceridemia. (21291769)
2008
27
Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver. (18357405)
2008
28
Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia. (17196967)
2008
29
Examination of the skin in hypertriglyceridemia. (18595869)
2008
30
Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis. (16883590)
2008
31
All-trans-retinoic acid as a possible cause of acute pancreatitis even in the absence of hypertriglyceridemia. (18566740)
2008
32
The role of hypertriglyceridemia in atherosclerosis. (17877919)
2007
33
Hypertriglyceridemia and cardiovascular risk reduction. (17697898)
2007
34
Hypertriglyceridemia and cardiovascular disease management. (18510282)
2007
35
Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia. (16940448)
2006
36
Priapism secondary to hypertriglyceridemia. (12576856)
2003
37
Insulin resistance but not hypertriglyceridemia per se is associated with endothelial dysfunction in chronic hypertriglyceridemia. (11827701)
2002
38
Apolipoprotein E1 Baden (Arg(180)-->Cys). A new apolipoprotein E variant associated with hypertriglyceridemia. (11163021)
2001
39
Lipoprotein lipase gene polymorphism and lipid profile in patients with hypertriglyceridemia. (11593500)
2001
40
Identification and treatment of hypertriglyceridemia as a risk factor for coronary heart disease. (10980847)
1999
41
Tumor necrosis factor alpha as a uremic toxin: correlation with neuropathy, left ventricular hypertrophy, anemia, and hypertriglyceridemia in peritoneal dialysis patients. (10682077)
1999
42
Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. (10606208)
1999
43
The TNF-beta gene Nco I polymorphism is not associated with hypertriglyceridemia or insulin resistance in lean and obese subjects. (9245742)
1997
44
Relationship of plasma cholesteryl ester transfer protein to HDL cholesterol. Studies in normotriglyceridemia and moderate hypertriglyceridemia. (8977446)
1996
45
Primary chylomicronemia in patients with severe familial hypertriglyceridemia responds to long-term treatment with (n-3) fatty acids. (7782902)
1995
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia. (8349676)
1993
48
Does familial hypertriglyceridemia predispose to NIDDM? (8299439)
1993
49
Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology and clinical course of hypertension. (1994722)
1991
50
Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. (1752964)
1991

Variations for Hypertriglyceridemia

About this section

Expression for genes affiliated with Hypertriglyceridemia

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypertriglyceridemia

Search GEO for disease gene expression data for Hypertriglyceridemia.

Pathways for genes affiliated with Hypertriglyceridemia

About this section
Sources:
51PathCards, 61Thomson Reuters, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 13EMD Millipore, 52PharmGKB
See all sources

Pathways related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8APOA2, APOA1
2
Show member pathways
9.8LPIN2, LPIN3, GPD1
3
Show member pathways
9.7LPIN3, LPL, LPIN2
49.7LPIN3, LPL, LPIN2
5
Show member pathways
9.6APOB, APOA1, APOE
69.4HMGCR, LDLR
7
Show member pathways
thioredoxin pathway39
9.4LDLR, APOB, APOA1
8
Show member pathways
fatty acid beta-oxidation VI (peroxisome)39
9.2APOA1, APOC3, APOA5, APOA2, LPL
99.2LDLR, HMGCR, SLC10A2
10
Show member pathways
9.1HMGCR, LPL, LDLR
119.1APOA1, APOA2, APOB, LPA
12
Show member pathways
8.1APOE, APOA1, APOC3, APOA2, APOC2, APOB
138.1APOE, APOA1, APOC3, APOA2, APOC2, APOB
14
Show member pathways
8.1APOE, APOA1, APOC3, APOA2, APOC2, APOB
15
Show member pathways
8.0GPD1, APOA1, APOA5, APOA2, LPIN3, LPL
16
Show member pathways
7.1APOB, APOC2, APOA2, APOA5, APOC3, APOA1
17
Show member pathways
6.9APOE, HMGCR, LPL, CETP, LDLR, APOB
18
Show member pathways
5.0LDLR, CETP, LPA, LPIN3, LPL, LPIN2

Compounds for genes affiliated with Hypertriglyceridemia

About this section
Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
See all sources

Compounds related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1fenofibric acid46 3010.1APOC3, APOB, LPL, HMGCR, APOA1
2campesterol46 2510.1HMGCR, APOE, APOA1, APOB
3psyllium469.0APOB, LDLR, CETP, HMGCR
4xbai468.9CETP, LPL, LDLR, APOB, APOC3, APOE
5dimyristoylphosphatidylcholine468.9LPA, APOA1, APOA2, APOA5, LDLR, APOE
6taurocholate468.9SLC10A2, APOA1, APOC3, APOB, LPL, HMGCR
7intralipid468.8APOA1, APOC3, APOA2, APOB, CETP, LPL
8tocopherol468.8LDLR, APOB, APOA1, HMGCR, LPL
9sele468.7LDLR, LPL, CETP, PON1, APOC3, APOE
10lathosterol46 259.7HMGCR, APOE, LDLR, APOB, CETP
117-ketocholesterol46 259.7APOE, APOA1, HMGCR, PON1, APOB
12oleic acid46 30 25 1211.7CETP, LPA, GPD1, LPL, LDLR, APOB
13ritonavir46 52 1210.6APOC3, LPL, HMGCR, LDLR, APOE
14ezetimibe46 129.6HMGCR, APOB, CETP, LDLR, APOA1
15rosiglitazone30 46 52 25 1212.6LPL, PON1, APOB, APOC3, APOE, GPD1
16palmitate468.5LPL, CETP, LDLR, APOB, APOA1, APOE
17mspi468.5APOA1, APOC3, APOA2, APOB, LDLR, CETP
18ursodeoxycholic acid46 25 1210.5LDLR, SLC10A2, LPA, HMGCR, APOE
19rosuvastatin46 52 30 1211.4APOC3, APOB, LDLR, CETP, HMGCR, APOE
20ciprofibrate46 309.4HMGCR, LPL, LDLR, APOB, APOA1, PON1
21probucol46 129.3APOE, APOA1, APOB, LDLR, CETP, LPL
22cholestyramine468.2APOB, LDLR, CETP, LPA, HMGCR, APOC3
23homocysteine46 259.2APOE, APOA1, LPA, APOC2, CETP, APOB
24sterol468.2SLC10A2, HMGCR, APOB, APOA1, APOE, CETP
25niacin46 129.1APOB, LPA, LPL, LDLR, APOA1, HMGCR
26fatty acid467.8LPL, LPA, APOC2, APOB, CETP, GPD1
27fluvastatin46 52 30 1210.8APOB, PON1, LDLR, CETP, LPL, HMGCR
28triacylglycerol467.8CETP, LPL, LDLR, APOB, APOC2, GPD1
29testosterone46 62 25 1210.7APOA1, GPD1, PON1, APOE, APOB, CETP
30alpha tocopherol467.7CETP, PON1, APOA1, APOE, LDLR, APOB
31glucose467.6APOA5, APOC2, APOA2, PON1, APOC3, APOA1
32phospholipid467.6CETP, APOA1, APOE, APOC3, APOA2, APOC2
33phosphatidylcholine467.6APOE, LPL, LPA, CETP, LDLR, PON1
34vitamin a46 25 129.5LPA, CETP, LDLR, PON1, APOB, APOC2
35aspirin46 52 30 2510.5LDLR, APOA1, APOE, APOB, PON1, CETP
36creatinine467.5HMGCR, PON1, LPA, APOE, APOB, APOC2
37thyroxine46 258.3CETP, APOE, HMGCR, LPL, LPA, LDLR
38bezafibrate46 30 129.3APOE, APOA1, APOC3, APOA2, APOB, LDLR
39simvastatin46 52 62 30 25 1212.2APOE, APOA1, APOA5, APOB, PON1, LDLR
40estrogen467.2LDLR, CETP, LPL, PON1, APOB, APOA2
41lovastatin46 52 62 30 1211.0APOE, APOA1, APOC3, APOA5, APOB, PON1
42pravastatin46 52 30 25 1210.9APOE, APOA1, APOC3, APOB, PON1, LDLR
43cholesterol ester466.8HMGCR, APOE, APOA1, APOC3, APOA2, APOB
44atorvastatin46 52 30 25 1210.7APOE, APOA1, APOC3, APOA5, APOB, PON1
45heparin46 30 25 129.7PON1, APOE, APOC3, APOA5, APOA2, APOC2
46fenofibrate46 52 128.6LPL, HMGCR, LPA, CETP, LDLR, APOE
47gemfibrozil30 46 128.6HMGCR, APOE, APOA1, APOC3, APOA2, APOC2
48serine466.3APOC2, PON1, SLC10A2, HMGCR, CETP, LDLR
49cholesterol46 30 25 128.3APOC3, SLC10A2, HMGCR, APOA5, APOA2, APOC2
50lipid465.1LPL, LPA, CETP, LDLR, PON1, APOB

GO Terms for genes affiliated with Hypertriglyceridemia

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:0343639.5APOE, APOC3, APOC2, APOB
2endocytic vesicle lumenGO:0716829.3APOE, APOA1, APOB
3low-density lipoprotein particleGO:0343629.2APOE, APOA5, APOC2, APOB, LDLR
4spherical high-density lipoprotein particleGO:0343669.1APOA1, APOC3, APOA2, APOC2, PON1
5blood microparticleGO:0725629.0PON1, APOA2, APOA1, APOE
6chylomicronGO:0426278.9APOE, APOC3, APOA5, APOA2, APOC2, APOB
7high-density lipoprotein particleGO:0343648.7APOE, APOA1, APOA5, APOA2, PON1, CETP
8very-low-density lipoprotein particleGO:0343618.6LPL, APOE, APOB, APOC2, APOA2, APOA5
9early endosomeGO:0057698.4APOE, APOA1, APOC3, APOA2, APOC2, APOB
10extracellular spaceGO:0056157.5APOE, APOA1, APOC3, APOA5, APOC2, APOB
11extracellular regionGO:0055767.0APOE, APOA1, APOC3, APOA5, APOA2, APOC2

Biological processes related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of very-low-density lipoprotein particle remodelingGO:01090210.4APOA5, APOC2
2negative regulation of very-low-density lipoprotein particle clearanceGO:01091610.3APOC2, APOC3
3negative regulation of lipid metabolic processGO:04583310.3APOC2, APOC3
4chylomicron remodelingGO:03437110.3LPL, APOC2
5negative regulation of cholesterol importGO:06062110.3APOC3, APOA2
6negative regulation of cholesterol transportGO:03237510.2APOA2, APOC2
7negative regulation of lipase activityGO:06019210.1APOA2, APOA1
8chylomicron remnant clearanceGO:03438210.1APOC3, APOC2, APOE
9triglyceride-rich lipoprotein particle remodelingGO:03437010.1APOA5, APOA2, APOC2
10positive regulation of lipid catabolic processGO:05099610.1APOA5, APOA2
11lipoprotein transportGO:04295310.1APOC3, APOC2, APOB
12regulation of Cdc42 protein signal transductionGO:03248910.1APOC3, APOA1, APOE
13regulation of intestinal cholesterol absorptionGO:03030010.1APOA2, APOA1
14negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.0APOC3, APOA1, APOA2
15cholesterol importGO:07050810.0LDLR, APOA1
16triglyceride mobilizationGO:00664210.0APOB, APOC3
17triglyceride biosynthetic processGO:01943210.0LPL, GPD1, LPIN2
18lipoprotein biosynthetic processGO:0421589.9APOE, APOA1, APOB
19negative regulation of cytokine secretion involved in immune responseGO:0027409.9APOA2, APOA1
20high-density lipoprotein particle assemblyGO:0343809.9APOA2, APOA1, APOE
21triglyceride catabolic processGO:0194339.9LPL, APOB, APOA5, APOC3
22positive regulation of cholesterol esterificationGO:0108739.9APOE, APOA1, APOA2
23peripheral nervous system axon regenerationGO:0140129.9APOA1, APOE
24organ regenerationGO:0311009.9APOA2, APOA5, APOA1
25peptidyl-methionine modificationGO:0182069.8APOA2, APOA1
26phospholipid metabolic processGO:0066449.8GPD1, LPIN2, LPL, LPIN3
27lipoprotein catabolic processGO:0421599.8APOE, APOB, LDLR
28positive regulation of triglyceride catabolic processGO:0108989.8APOA5, APOC2
29very-low-density lipoprotein particle remodelingGO:0343729.8CETP, LPL, APOC2, APOE
30high-density lipoprotein particle clearanceGO:0343849.8APOA1, APOE, APOC2, APOA2
31protein oxidationGO:0181589.7APOA2, APOA1
32phosphatidylcholine biosynthetic processGO:0066569.7APOA1, LPIN3, LPIN2, APOA2
33lipid transportGO:0068699.7LPA, CETP, APOA5
34low-density lipoprotein particle remodelingGO:0343749.6CETP, APOB, APOA2, APOE
35phospholipid effluxGO:0337009.6APOC3, APOE, APOA1, APOA2, APOC2
36response to drugGO:0424939.5APOA2, APOC3, LPL, APOA1, APOC2
37cholesterol transportGO:0303019.4APOA1, LDLR, CETP, APOB
38high-density lipoprotein particle remodelingGO:0343759.4APOE, APOC3, APOA1, APOA2, CETP
39triglyceride homeostasisGO:0703289.4APOC3, APOA5, APOA1, CETP, LPL, APOC2
40triglyceride metabolic processGO:0066419.3LPL, APOA5, APOE, CETP, APOC3, APOA2
41cholesterol effluxGO:0333449.2APOC2, APOC3, APOB, APOA2, APOA1, APOE
42reverse cholesterol transportGO:0436919.2APOC2, APOE, APOC3, APOA2, CETP, APOA1
43receptor-mediated endocytosisGO:0068989.0LDLR, CETP, LPA, APOB, APOE
44cellular lipid metabolic processGO:0442559.0GPD1, LPIN2, APOA2, APOA5, HMGCR, APOA1
45cholesterol metabolic processGO:0082038.6CETP, LDLR, APOB, APOA2, APOA1, APOE
46phototransduction, visible lightGO:0076038.5APOE, APOA1, APOC3, APOA2, APOC2, APOB
47retinoid metabolic processGO:0015238.5APOC2, APOA2, APOC3, APOA1, APOE, LPL
48cholesterol homeostasisGO:0426328.3APOA1, APOE, CETP, APOC3, APOA5, LDLR
49lipoprotein metabolic processGO:0421577.6LPL, LPA, CETP, LDLR, APOB, APOC2
50small molecule metabolic processGO:0442816.0SLC10A2, HMGCR, LPIN2, LPL, LPIN3, APOE

Molecular functions related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein lipase activator activityGO:06023010.2APOC2, APOA5
2lipase bindingGO:03547310.1APOB, APOA5
3triglyceride bindingGO:01712910.0CETP, LPL
4phospholipase activityGO:00462010.0LPL, LIPI
5apolipoprotein receptor bindingGO:03419010.0APOA2, APOA1
6low-density lipoprotein particle receptor bindingGO:05075010.0APOB, APOA5, APOE
7high-density lipoprotein particle receptor bindingGO:0706539.9APOA2, APOC3, APOA1
8phospholipid transporter activityGO:0055489.9APOA1, CETP
9phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.8APOA2, APOA1, APOE
10phosphatidylcholine bindingGO:0312109.8CETP, APOA2, APOA5
11apolipoprotein bindingGO:0341859.8LPL, LPA
12lipase inhibitor activityGO:0551029.7APOC2, APOA2, APOC3, APOA1
13high-density lipoprotein particle bindingGO:0080359.7APOA2, APOA1
14lipid transporter activityGO:0053199.7APOE, APOA2, CETP
15phosphatidate phosphatase activityGO:0081959.7LPIN2, LPIN3
16cholesterol bindingGO:0154859.6APOA1, APOC3, APOA2, CETP
17lipid bindingGO:0082899.4APOE, APOA5, APOA2, APOC2, CETP
18cholesterol transporter activityGO:0171279.2APOE, APOA1, APOA2, APOB, CETP
19heparin bindingGO:0082019.1APOE, APOA5, APOB, LIPI, LPA, LPL
20phospholipid bindingGO:0055438.7PON1, APOB, APOA2, APOA5, APOC3, APOA1
21protein homodimerization activityGO:0428038.5HMGCR, PON1, APOC2, APOA2, APOE, GPD1

Products for genes affiliated with Hypertriglyceridemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertriglyceridemia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet