MCID: HYP117
MIFTS: 63

Hypertriglyceridemia malady

Metabolic, Endocrine, Genetic categories

Summaries for Hypertriglyceridemia

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Hypertriglyceridemia denotes high (hyper-) blood levels (-emia) of triglycerides, the most abundant... more...

MalaCards: Hypertriglyceridemia, also known as hyperlipoproteinemia type 4, is related to familial hypertriglyceridemia and acute pancreatitis. An important gene associated with Hypertriglyceridemia is APOA5 (apolipoprotein A-V), and among its related pathways are Metabolism and Statin Pathway, Pharmacodynamics. The compounds lipid and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and heart, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Description from OMIM:47 144600,145750

Aliases & Classifications for Hypertriglyceridemia

Sources:
49Orphanet, 47OMIM, 45Novoseek, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Metabolic, Endocrine


Characteristics (Orphanet epidemiological data):

49
hyperlipoproteinemia type 4:
Inheritance: Autosomal dominant; Age of onset: Adulthood


Aliases & Descriptions:

hypertriglyceridemia 47 45
hyperlipoproteinemia type 4 49 47
familial hypertriglyceridemia 49


External Ids:

MESH via Orphanet36 D006953
ICD10 via Orphanet26 E78.1
SNOMED-CT via Orphanet58 238085009, 267433009, 34528009
UMLS via Orphanet62 C0020480

Related Diseases for Hypertriglyceridemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hypertriglyceridemia family:

familial hypertriglyceridemia

Diseases related to Hypertriglyceridemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1familial hypertriglyceridemia31.1APOB, LPL, SLC10A2, APOC3
2acute pancreatitis30.9LPL, APOC2
3insulin resistance30.9APOA1, APOC3, APOA2, APOB, LPA, LPL
4hypercholesterolemia30.7LPA, LPL, LIPC, PON1, SLC10A2, CETP
5lipoprotein lipase deficiency30.5LPL
6familial combined hyperlipidemia30.5APOA1, APOE, APOB
7atherosclerosis30.4APOA1, APOE, APOA5, APOC3, APOA2, APOC2
8coronary heart disease30.4APOA1, APOE, APOA5, APOC3, APOA2, APOC2
9coronary artery disease,30.3APOA1, LIPC, LPL, LPA, APOB, APOA2
10hypoalphalipoproteinemia30.2APOA1, APOC3, APOA2, APOB, LPL, LIPC
11familial lipoprotein lipase deficiency30.2LPL
12hyperlipidemia type 330.1APOA1, APOE, APOA5, APOB, LPA, LPL
13glucose intolerance30.1APOB, LPL
14vascular disease30.0APOA1, APOE, APOC2, APOB, LPA, LPL
15familial hypercholesterolemia30.0APOB, CETP, LDLR
16fish-eye disease30.0APOA1, APOA2
17tangier disease29.7APOA1, APOE, APOC3, APOA2, APOB, LPA
18hyperalphalipoproteinemia29.7APOA1, APOC3, APOA2, APOB, LIPC, CETP
19uremia29.7LDLR, APOC3, LPA, LPL, LIPC, PON1
20fatty liver disease29.7APOA1, APOC3, APOB, LPL, LIPC, CETP
21diabetic nephropathy29.7PON1, APOA1, APOE, APOB, LPA, LIPC
22hyperhomocysteinemia29.7PON1, LPA, APOE
23stroke, ischemic29.7LPA, APOB, APOE, APOA1
24lipase deficiency combined29.7LPL, LIPC
25hyperuricemia29.7APOB
26hyperinsulinism29.7APOB, LPL
27hyperlipoproteinemia type iv10.3
28acute leukemia10.3
29hypertriglyceridemia, transient infantile10.3
30lip disease10.2
31recurrent acute pancreatitis10.2
32diabetic ketoacidosis10.1
33apo a-i deficiency10.1
34hyperapobetalipoproteinemia10.1
35obesity10.0LIPC, PON1, GPD1, CETP, LDLR, LPL
36familial hyperlipidemia10.0PON1, CETP, LDLR, LIPC, LPL, LPA
37type 2 diabetes mellitus10.0APOA1, APOE, APOC3, APOA2, APOC2, APOB
38diabetes mellitus10.0APOA1, APOE, CETP, PON1, LPL, LPA
39myocardial infarction10.0APOA1, APOE, APOA5, APOC3, APOA2, APOB
40atypical lipodystrophy10.0
41congenital generalized lipodystrophy type 210.0
42lipodystrophy, familial partial, type 210.0
43griscelli syndrome type 110.0
44mandibuloacral dysplasia with type b lipodystrophy10.0
45nephrotic syndrome10.0APOA1, APOE, APOB, LPA, LPL, PON1
46chronic kidney failure10.0APOA1, APOC2, APOB, LPA, LPL, LIPC
47ischemic heart disease10.0APOA1, APOB, LPA, LPL, LIPC, PON1
48galactosemia10.0APOA1, APOC3, APOB, LPA, LIPC, SLC10A2
49cadasil10.0APOE, APOB, LPA, LPL, LIPC, PON1
50proteinuria10.0APOA1, APOC3, APOA2, APOC2, APOB, LPA

Graphical network of the top 20 diseases related to Hypertriglyceridemia:



Diseases related to hypertriglyceridemia

Clinical Features for Hypertriglyceridemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

144600,145750

Clinical synopsis from OMIM:

144600

Drugs & Therapeutics for Hypertriglyceridemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypertriglyceridemia

Drug clinical trials:

Search ClinicalTrials for Hypertriglyceridemia

Search NIH Clinical Center for Hypertriglyceridemia

Search CenterWatch for Hypertriglyceridemia

Genetic Tests for Hypertriglyceridemia

Anatomical Context for Hypertriglyceridemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hypertriglyceridemia:

33
Whole blood, Brain, Heart, Small intestine, Adipocyte, Kidney, Liver, Lung, Breast, Skin, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Hypertriglyceridemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hypertriglyceridemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.8LPL, APOC3, APOA2, APOB, APOE, LIPC
2MP:000538510.7RP1, APOA1, APOE, APOC3, APOB, LPL
3MP:000537010.4LDLR, SLC10A2, LIPI, LPL, APOB, APOE

Publications for Hypertriglyceridemia

Sources:
51PubMed
See all sources

Articles related to Hypertriglyceridemia:

(show top 50)    (show all 769)
idTitleAuthorsYear
1
The calcium-sensing receptor R990G polymorphism is associated with increased risk of hypertriglyceridemia in obese Chinese. (24120622)
2014
2
Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters. (24393244)
2014
3
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. (23836343)
2013
4
Hypertriglyceridemia is a practical biomarker of metabolic syndrome in individuals with abdominal obesity. (23259588)
2013
5
Etanercept-induced hypertriglyceridemia during the treatment of recurrent aphthous stomatitis. (23619454)
2013
6
Relationship between the distribution of plasma HDL subclasses and the polymorphisms of APOA5 in hypertriglyceridemia. (23499587)
2013
7
A highly bioavailable omega-3 free fatty acid formulation improves the cardiovascular risk profile in high-risk, statin-treated patients with residual hypertriglyceridemia (the ESPRIT trial). (23998969)
2013
8
Leu452His mutation in lipoprotein lipase gene transfer associated with hypertriglyceridemia in mice in vivo. (24086538)
2013
9
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. (22135386)
2012
10
Use of plasmapheresis in managing the diagnostic dilemma of symptomatic hypertriglyceridemia. (23304575)
2012
11
Patient information page from The Hormone Foundations. Patient guide to the assessment and treatment of hypertriglyceridemia (high triglycerides). (22962678)
2012
12
Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy. (21150557)
2011
13
L-Asparaginase and steroids-associated hypertriglyceridemia successfully treated with plasmapheresis in a child with acute lymphoblastic leukemia. (21399528)
2011
14
Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol. (21314630)
2011
15
Management of hypertriglyceridemia in the diabetic patient. (20532703)
2010
16
Emergent therapy with therapeutic plasma exchange in acute recurrent pancreatitis due to severe hypertriglyceridemia. (20926345)
2010
17
The Gln27Glu polymorphism in I^2-adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis. (20738880)
2010
18
Characterization of hypertriglyceridemia and response to treatment with insulin in horses, ponies, and donkeys: 44 cases (1995-2005). (19335242)
2009
19
Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects. (19656007)
2009
20
Plant stanol supplementation decreases serum triacylglycerols in subjects with overt hypertriglyceridemia. (19904567)
2009
21
Severe hypertriglyceridemia: an indication for apheresis? (20129374)
2009
22
Which dose of omega-3 fatty acids must be taken in different cases of hypertriglyceridemia? (19157275)
2008
23
ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia. (18767813)
2008
24
Pathologic findings in rabbit models of hereditary hypertriglyceridemia and hereditary postprandial hypertriglyceridemia. (19004373)
2008
25
Treating hypertriglyceridemia. (17846443)
2007
26
Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency. (17468529)
2007
27
Focus on hypertriglyceridemia: improving patient outcomes. (18510280)
2007
28
Treating hypertriglyceridemia. (17846446)
2007
29
Treating hypertriglyceridemia. (17846444)
2007
30
Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. (16943421)
2006
31
Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice. (16478678)
2006
32
Analysis of cholesterol ester transfer protein gene Taq IB and -629 C/A polymorphisms in patients with endogenous hypertriglyceridemia in Chinese population]. (17160943)
2006
33
Capecitabine-induced severe hypertriglyceridemia: report of two cases. (16391007)
2006
34
Hypertriglyceridemia: interaction between APOE and APOAV variants. (15976129)
2005
35
Hypertriglyceridemia--diagnostics, risk and treatment]. (15534665)
2004
36
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. (14633850)
2003
37
Hypertriglyceridemia associated with amino acid variation Asn985Tyr of the RP1 gene. (12764676)
2003
38
Genotype-phenotype studies of six novel LPL mutations in Chinese patients with hypertriglyceridemia. (12204001)
2002
39
Platelet function in patients with familial hypertriglyceridemia: evidence that platelet reactivity is modulated by apolipoprotein E content of very-low-density lipoprotein particles. (10910008)
2000
40
The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein lipase: no effects on VLDL substrate affinity to lipolysis or LDL receptor binding. (11164425)
2000
41
Polymorphic markers in apolipoprotein C-III gene flanking regions and hypertriglyceridemia. (8696957)
1996
42
Abnormal bile acid absorption in familial hypertriglyceridemia. (7706952)
1995
43
Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. (8163669)
1994
44
Hypertriglyceridemia: cause or consequence of insulin resistance? (1306513)
1992
45
Effect of dietary treatment on the lipid, lipoprotein and fatty acid compositions in type IV familial hypertriglyceridemia. (1776822)
1991
46
Insulin resistance and action in hypertriglyceridemia. (1748063)
1991
47
Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: normolipemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia. (7266376)
1981
48
Inheritance of apolipoprotein C-II deficiency with hypertriglyceridemia and pancreatitis. (213719)
1978
49
Familial hypertriglyceridemia in children: dietary management. (904981)
1977
50
Familial hypertriglyceridemia: studies in 130 children and 45 siblings of 36 index cases. (4784529)
1973

Genetic Variations for Hypertriglyceridemia

Expression for genes affiliated with Hypertriglyceridemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypertriglyceridemia

Search GEO for disease gene expression data for Hypertriglyceridemia.

Pathways for genes affiliated with Hypertriglyceridemia

Sources:
54Reactome, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Pathways related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9APOA2, APOC3, APOA5, APOE, APOA1, APOC2
2
Hide members
10.8LDLR, APOA1, CETP, LIPC, LPL, APOB
3
Hide members
10.8CETP, LPL, LPA, APOB, APOC2, APOA2
410.7APOA1, APOE, APOC3, APOA2, APOC2, APOB
5
Hide members
10.7APOA1, APOE, APOC3, APOA2, APOC2, APOB
6
Hide members
10.7APOA1, APOE, APOC3, APOA2, APOC2, APOB
7
Hide members
10.7APOA1, APOA5, APOA2, LPIN2, LPIN3, GPD1
810.6APOA1, APOA5, APOC3, APOA2, LPL
910.6LIPC, LPIN3, LPL, LPIN2
1010.6APOA1, APOA2, APOB, LPA
1110.6APOB, LPA, CETP, LDLR
12
Hide members
10.6LPIN2, LPIN3, GPD1
13
Hide members
10.6LPL, LIPC, GPD1
14
Hide members
10.6APOA1, APOE, APOB
1510.6APOA1, APOE, APOB
1610.6LDLR, APOB, APOA1
1710.5APOB, APOA1

Compounds for genes affiliated with Hypertriglyceridemia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1lipid4511.3APOB, APOA2, APOC3, APOA5, APOE, APOA1
2cholesterol45 29 11 2414.3APOA1, APOE, APOA5, APOC3, APOA2, APOC2
3triacylglycerol4511.3APOA5, APOC3, APOA2, APOC2, APOB, LPL
4phospholipid4511.2LPL, LIPC, PON1, CETP, LDLR, APOB
5heparin45 29 11 2414.2APOE, APOA5, APOC3, APOA2, APOC2, APOB
6gemfibrozil45 29 1113.2APOC2, APOA2, APOC3, APOE, APOA1, PON1
7cholesterol ester4511.2PON1, APOA1, LIPC, LPL, LPA, APOB
8atorvastatin45 50 29 11 2415.2PON1, SLC10A2, CETP, LDLR, LIPC, LPL
9fenofibrate45 50 1113.2APOA2, APOB, LPA, LPL, LIPC, PON1
10vitamin a45 11 2413.2APOA1, APOC2, APOE, APOC3, APOB, LPA
11lovastatin45 50 60 29 1115.2LDLR, CETP, PON1, LIPC, LPL, LPA
12fatty acid4511.2GPD1, LIPC, LPL, CETP, LDLR, APOC3
13phosphatidylcholine4511.2APOA1, APOE, APOA2, APOB, LPA, LPL
14bezafibrate45 29 1113.2APOA1, APOE, APOC3, APOA2, APOB, LPA
15pravastatin45 50 29 11 2415.2APOE, APOA1, LDLR, CETP, SLC10A2, PON1
16thyroxine45 2412.1APOA1, LDLR, CETP, LIPC, LPL, LPA
17intralipid4511.1APOE, APOA1, APOC3, APOA2, CETP, LIPC
18probucol45 1112.1CETP, LIPC, LPL, APOB, APOE, APOA1
19estrogen4511.1APOA1, LPL, APOB, APOA2, APOC3, PON1
20testosterone45 60 11 2414.1LIPC, APOA1, APOE, APOC3, APOB, LDLR
21homocysteine45 2412.1PON1, APOB, APOC2, APOE, APOA1, LPA
22mspi4511.1LDLR, CETP, APOA1, APOC3, APOA2, APOB
23simvastatin45 50 60 29 11 2416.1APOA1, APOE, APOB, LPA, LPL, PON1
24cholestyramine4511.1LDLR, CETP, LPA, APOB, APOC3, APOE
25fluvastatin45 50 29 1114.0APOB, PON1, CETP, LDLR, APOA1, APOE
26sele4511.0APOE, APOC3, LPL, CETP, LDLR, PON1
27dimyristoylphosphatidylcholine4511.0APOA5, APOA2, APOE, APOA1, LPA, LDLR
28oleic acid45 29 11 2414.0LPA, LIPC, GPD1, CETP, LDLR, APOB
29niacin45 1112.0LPA, LPL, CETP, LDLR, APOA1, APOB
30glucose4511.0APOA1, APOA5, APOC3, APOA2, APOC2, LPA
31xbai4511.0APOE, APOC3, LPL, LDLR
32sterol4511.0APOA1, APOE, LDLR, CETP, SLC10A2, LIPC
33ciprofibrate45 2912.0PON1, LPL, APOB, LDLR, APOA1
34aspirin45 50 29 2413.9APOB, LPA, PON1, LDLR, APOE, APOA1
35trioleoylglycerol4510.9APOA1, APOC2, LIPC, LPL
36rosuvastatin45 50 29 1113.9APOC3, APOB, CETP, APOA1, LDLR
37sodium dodecylsulfate4510.9LIPC, APOE, LPL, APOC2, LPA, CETP
38taurocholate4510.9SLC10A2, APOA1, LPL, APOB, APOC3
39alpha tocopherol4510.9LPL, LDLR
40rosiglitazone45 50 29 11 2414.8GPD1
41fenofibric acid45 2911.8APOC3, APOB, APOA1, LPL
42dextran sulfate4510.8APOB, APOA1, CETP, LDLR, LPL
43lathosterol45 2411.8CETP, LDLR, APOE, APOB
44palmitate4510.8LDLR, CETP
45carbohydrates4510.7LPL, APOE, APOC3, LIPC, CETP, LDLR
46retinyl palmitate45 2411.7LPL, APOB, APOE, APOA1
47fibrinogen4510.7APOB, LPA, APOA2, APOC3, APOA1, LIPC
48betacarotene4510.6CETP, PON1, LPL, APOB, APOE
497-ketocholesterol45 2411.5APOA1, APOB, PON1, APOE
50vitamin b124510.3APOA1, APOE, APOB, LPA, PON1

GO Terms for genes affiliated with Hypertriglyceridemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypertriglyceridemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:03436110.9LPL, APOB, APOC2, APOA2, APOC3, APOA5
2high-density lipoprotein particleGO:03436410.9APOE, APOA1, APOA5, APOA2, LIPC, CETP
3extracellular spaceGO:00561510.9APOA1, APOE, APOA5, APOC3, APOC2, APOB
4chylomicronGO:04262710.9LPL, APOB, APOC2, APOA2, APOC3, APOA5
5spherical high-density lipoprotein particleGO:03436610.8APOA1, APOC3, APOA2, APOC2, PON1
6low-density lipoprotein particleGO:03436210.7APOE, APOA5, APOC2, APOB, LDLR
7intermediate-density lipoprotein particleGO:03436310.6APOE, APOC3, APOC2, APOB
8early endosomeGO:00576910.6APOA1, APOE, APOC3, APOA2, APOC2, APOB
9endocytic vesicle lumenGO:07168210.6APOB, APOE, APOA1
10extracellular regionGO:00557610.5APOA1, APOE, APOA5, APOC3, APOA2, APOC2

Biological processes related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.4APOC2, APOA2, APOC3, APOA5, APOE, APOA1
2lipoprotein metabolic processGO:04215711.2APOA1, APOE, APOA5, APOC3, APOA2, APOC2
3cholesterol homeostasisGO:04263211.2CETP, LDLR, LIPC, APOB, APOC2, APOA1
4phototransduction, visible lightGO:00760311.2RP1, APOA1, APOE, APOC3, APOA2, APOC2
5cholesterol metabolic processGO:00820311.2APOA1, APOE, APOC3, APOA2, APOB, LIPC
6retinoid metabolic processGO:00152311.2APOC3, APOA2, APOC2, APOB, LPL, LDLR
7triglyceride homeostasisGO:07032811.1APOA1, APOA5, APOC3, APOC2, LPL, LIPC
8reverse cholesterol transportGO:04369111.1APOA1, APOE, APOC3, APOA2, APOC2, LIPC
9cholesterol effluxGO:03334411.1APOA1, APOE, APOC3, APOA2, APOC2, APOB
10triglyceride metabolic processGO:00664111.1APOE, APOA5, APOC3, APOA2, LPL, CETP
11high-density lipoprotein particle remodelingGO:03437511.1APOA1, APOE, APOC3, APOA2, LIPC, CETP
12phospholipid effluxGO:03370011.0APOA1, APOE, APOC3, APOA2, APOC2
13very-low-density lipoprotein particle remodelingGO:03437211.0APOE, APOC2, LPL, LIPC, CETP
14triglyceride catabolic processGO:01943311.0APOA5, APOC3, APOB, LPL, LIPC
15low-density lipoprotein particle remodelingGO:03437411.0APOE, APOA2, APOB, LIPC, CETP
16receptor-mediated endocytosisGO:00689811.0APOE, APOB, LPA, CETP, LDLR
17chylomicron remnant clearanceGO:03438211.0APOE, APOC3, APOC2, LIPC
18high-density lipoprotein particle clearanceGO:03438411.0APOA1, APOE, APOA2, APOC2
19cellular lipid metabolic processGO:04425511.0APOA1, APOA5, APOA2, LPIN2, GPD1
20cholesterol transportGO:03030111.0LDLR, CETP, APOB, APOA1
21phosphatidylcholine biosynthetic processGO:00665611.0APOA1, APOA2, LPIN2, LPIN3
22response to drugGO:04249311.0APOA1, APOC3, APOA2, APOC2, LPL
23triglyceride-rich lipoprotein particle remodelingGO:03437011.0APOA5, APOA2, APOC2
24negative regulation of very-low-density lipoprotein particle remodelingGO:01090311.0APOA1, APOC3, APOA2
25regulation of Cdc42 protein signal transductionGO:03248910.9APOA1, APOE, APOC3
26lipoprotein catabolic processGO:04215910.9APOE, APOB, LDLR
27lipoprotein biosynthetic processGO:04215810.9APOA1, APOE, APOB
28high-density lipoprotein particle assemblyGO:03438010.9APOA1, APOE, APOA2
29positive regulation of cholesterol esterificationGO:01087310.9APOA2, APOE, APOA1
30lipoprotein transportGO:04295310.9APOB, APOC2, APOC3
31positive regulation of very-low-density lipoprotein particle remodelingGO:01090210.9APOC2, APOA5
32phospholipid metabolic processGO:00664410.9LPIN2, LPL, LPIN3, GPD1
33negative regulation of cholesterol importGO:06062110.9APOA2, APOC3
34organ regenerationGO:03110010.9APOA1, APOA5, APOA2
35cholesterol importGO:07050810.9APOA1, LDLR
36triglyceride biosynthetic processGO:01943210.9LPIN2, LPL, GPD1
37negative regulation of lipase activityGO:06019210.8APOA1, APOA2
38chylomicron remodelingGO:03437110.8APOC2, LPL
39negative regulation of lipid metabolic processGO:04583310.8APOC3, APOC2
40negative regulation of cholesterol transportGO:03237510.8APOA2, APOC2
41regulation of intestinal cholesterol absorptionGO:03030010.8APOA1, APOA2
42negative regulation of very-low-density lipoprotein particle clearanceGO:01091610.7APOC3, APOC2
43positive regulation of lipid catabolic processGO:05099610.7APOA5, APOA2
44protein oxidationGO:01815810.7APOA1, APOA2
45peripheral nervous system axon regenerationGO:01401210.6APOA1, APOE
46triglyceride mobilizationGO:00664210.6APOC3, APOB
47negative regulation of receptor-mediated endocytosisGO:04826110.5APOC2, APOC3
48negative regulation of cytokine secretion involved in immune responseGO:00274010.5APOA1, APOA2
49lipid transportGO:00686910.5APOA5, LPA, CETP
50peptidyl-methionine modificationGO:01820610.2APOA2, APOA1

Molecular functions related to Hypertriglyceridemia according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00820111.0APOE, APOA5, APOB, LPA, LPL, LIPC
2phospholipid bindingGO:00554311.0APOA1, APOE, APOA5, APOC3, APOA2, APOB
3cholesterol transporter activityGO:01712711.0CETP, APOB, APOA2, APOE, APOA1
4lipase inhibitor activityGO:05510210.9APOA1, APOC3, APOA2, APOC2
5lipid bindingGO:00828910.9APOE, APOA5, APOA2, APOC2, CETP
6cholesterol bindingGO:01548510.9CETP, APOA2, APOC3, APOA1
7high-density lipoprotein particle receptor bindingGO:07065310.9APOA2, APOC3, APOA1
8phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.9APOA1, APOE, APOA2
9phospholipase activityGO:00462010.8LIPI, LIPC, LPL
10phosphatidylcholine bindingGO:03121010.8CETP, APOA2, APOA5
11low-density lipoprotein particle receptor bindingGO:05075010.8APOE, APOA5, APOB
12apolipoprotein bindingGO:03418510.8LPA, LPL, LIPC
13lipid transporter activityGO:00531910.8APOE, APOA2, CETP
14triglyceride bindingGO:01712910.7CETP, LPL
15lipoprotein lipase activator activityGO:06023010.7APOA5, APOC2
16apolipoprotein receptor bindingGO:03419010.7APOA1, APOA2
17phospholipid transporter activityGO:00554810.6CETP, APOA1
18high-density lipoprotein particle bindingGO:00803510.6APOA1, APOA2
19phosphatidate phosphatase activityGO:00819510.5LPIN3, LPIN2
20triglyceride lipase activityGO:00480610.5LIPC, LPL
21protein homodimerization activityGO:04280310.5APOE, APOA2, APOC2, PON1, GPD1
22low-density lipoprotein particle bindingGO:03016910.2LDLR, LIPC

Products for genes affiliated with Hypertriglyceridemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertriglyceridemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet