MCID: HYP117
MIFTS: 61

Hypertriglyceridemia malady

Genetic diseases (common) category

Aliases & Classifications for Hypertriglyceridemia

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Aliases & Descriptions for Hypertriglyceridemia:

Name: Hypertriglyceridemia 46 44
Hypertriglyceridemias Familial 44 22
Familial Hypertriglyceridemia 8 10
 
Hypertriglyceridemia, Susceptibility to 9
Hyperlipoproteinemia Type Iv 61
Pure Hyperglyceridemia 8


Classifications:



External Ids:

OMIM46 145750
Disease Ontology8 DOID:0050527

Summaries for Hypertriglyceridemia

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OMIM:46 Most individuals with familial hypertriglyceridemia have a hyperlipoproteinemia IV (144600) phenotype. Relatives of... (145750) more...

MalaCards based summary: Hypertriglyceridemia, also known as hypertriglyceridemias familial, is related to hyperlipidemia, familial combined and norum disease, and has symptoms including autosomal dominant inheritance, atheroeruptive xanthoma and abnormal glucose tolerance. An important gene associated with Hypertriglyceridemia is APOA5 (apolipoprotein A-V), and among its related pathways are Vitamin digestion and absorption and Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF . The compounds fenofibric acid and retinyl palmitate have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and liver, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Disease Ontology:8 A lipid metabolism disorder characterized by elevated triglyceride levels as a result of excess hepatic production of vldl or heterozygous lpl deficiency.

Wikipedia:64 Hypertriglyceridemia denotes high (hyper-) blood levels (-emia) of triglycerides, the most abundant... more...

Related Diseases for Hypertriglyceridemia

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Diseases in the Hypertriglyceridemia family:

Hypertriglyceridemia, Transient Infantile

Diseases related to Hypertriglyceridemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1hyperlipidemia, familial combined30.4APOB, APOA1, APOE
2norum disease30.4APOA1, APOA2
3fish-eye disease30.4APOA1, APOA2
4lipodystrophy30.0APOB, LPL, LDLR, APOC3
5alagille syndrome29.8APOA1, LPA
6hyperglycemia29.8LPL, APOB, PON1, CETP, LPA
7hyperhomocysteinemia29.7LPA, APOE, PON1
8kidney disease29.7LPA, APOE, APOA1, APOB, LPL
9glucose intolerance29.7LPL, APOA1, PON1, APOB, APOC2, CETP
10hypercholesterolemia, familial29.7APOB, LDLR, CETP
11fatty liver disease29.6APOA1, APOC3, LPL, CETP, APOB
12hypothyroidism29.6APOB, CETP, LPA, LDLR
13hypoalphalipoproteinemia29.4APOA1, APOC3, APOA2, APOB, LDLR, CETP
14uremia29.1LDLR, PON1, LPA, LPL, APOC3
15hyperalphalipoproteinemia29.1LDLR, APOB, CETP, APOA2, APOC3, APOA1
16coronary artery disease29.1LPL, LPA, CETP, LDLR, PON1, APOB
17proteinuria29.1APOC3, APOA2, APOB, CETP, LPA, APOA1
18hyperinsulinism29.0APOA1, LPL, APOA2, APOB, LDLR, CETP
19hyperlipidemia type 329.0LPL, LPA, CETP, LDLR, APOB, APOA5
20nephrotic syndrome28.9APOB, LPA, APOE, APOA1, LPL, PON1
21obesity28.8LDLR, CETP, LPA, LPL, GPD1, APOE
22tangier disease28.8LPL, LPA, CETP, APOB, APOA2, APOC3
23vascular disease28.4APOE, APOA1, APOC2, APOB, PON1, LDLR
24atherosclerosis28.1APOE, APOA1, APOC3, APOA5, APOA2, APOC2
25myocardial infarction28.0APOA1, APOC3, APOA5, APOA2, APOB, PON1
26familial hyperlipidemia27.6APOC3, APOA5, APOA2, APOA1, APOE, LPL
27pancreatitis10.8
28acute pancreatitis10.7
29hepatitis10.5
30steatorrhea10.5SLC10A2
31lipoprotein glomerulopathy10.5APOE
32endotheliitis10.4
33cerebral atherosclerosis10.4APOA1
34lipoprotein lipase deficiency10.4
35chylomicron retention disease10.4APOB
36hypertriglyceridemia, transient infantile10.3
37leukemia10.3
38hyperchylomicronemia, late-onset10.3APOE, APOC2, LPL
39arcus senilis10.3APOA1, APOB
40macular degeneration, age-related, 110.3APOB, APOE
41diabetic ketoacidosis10.3
42lymphoblastic leukemia10.3
43amyloidosis, familial visceral10.2APOA1, APOA2
44artery disease10.2
45carotid artery disease10.2PON1, APOB
46familial lipoprotein lipase deficiency10.2
47transient infantile hypertriglyceridemia and hepatosteatosis10.2
48recurrent acute pancreatitis10.2
49alzheimer disease-210.1APOE, CETP
50pancreatitis, hereditary10.1APOC2, APOB, LPL

Graphical network of the top 20 diseases related to Hypertriglyceridemia:



Diseases related to hypertriglyceridemia

Symptoms for Hypertriglyceridemia

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Symptoms by clinical synopsis from OMIM:

145750

Clinical features from OMIM:

145750

HPO human phenotypes related to Hypertriglyceridemia:

(show all 6)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 atheroeruptive xanthoma HP:0001039
3 abnormal glucose tolerance HP:0001952
4 hypertriglyceridemia HP:0002155
5 increased circulating very-low-density lipoprotein cholesterol HP:0003362
6 precocious atherosclerosis HP:0004416

Drugs & Therapeutics for Hypertriglyceridemia

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Drug clinical trials:

Search ClinicalTrials for Hypertriglyceridemia

Search NIH Clinical Center for Hypertriglyceridemia

Genetic Tests for Hypertriglyceridemia

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Genetic tests related to Hypertriglyceridemia:

id Genetic test Affiliating Genes
1 Familial Hypertriglyceridemia22

Anatomical Context for Hypertriglyceridemia

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MalaCards organs/tissues related to Hypertriglyceridemia:

31
Heart, Skin, Liver, Endothelial, Monocytes, Kidney, Lung, Prostate, Bone, Whole blood, Brain, Adipocyte, Breast

Animal Models for Hypertriglyceridemia or affiliated genes

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MGI Mouse Phenotypes related to Hypertriglyceridemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.6APOE, APOA1, APOB, LIPI, LDLR, LPL
2MP:00053857.5APOA1, APOC3, APOB, PON1, LDLR, LPL
3MP:00053786.8GPD1, APOE, APOC3, APOA2, APOB, LIPI
4MP:00053766.0SLC10A2, GPD1, APOE, APOA1, APOC3, APOA5

Publications for Hypertriglyceridemia

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Articles related to Hypertriglyceridemia:

(show top 50)    (show all 800)
idTitleAuthorsYear
1
Systemic Alterations in the Metabolome of Diabetic NOD Mice Delineate Increased Oxidative Stress Accompanied by Reduced Inflammation and Hypertriglyceridemia. (25852003)
2015
2
Impact of hypertriglyceridemia on the outcome of acute biliary pancreatitis. (25171545)
2014
3
Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291). (25127531)
2014
4
Hypertriglyceridemia, lipemia, and elevated liver enzymes associated with prolonged propofol anesthesia for craniotomy. (25222854)
2014
5
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. (23836343)
2013
6
Effect of green tea extract microencapsulation on hypertriglyceridemia and cardiovascular tissues in high fructose-fed rats. (24133615)
2013
7
Metabolic surgery for the treatment of hypertriglyceridemia-related pancreatitis due to familial lipoprotein lipase deficiency. (24680758)
2013
8
Primary Hypertriglyceridemia type IV : severe incidentaloma of early presentation. (24343502)
2013
9
Effects of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on hyperinsulinemia and hypertriglyceridemia in prediabetic Zucker fatty rats. (23917858)
2013
10
What should we do about Hypertriglyceridemia in Coronary Artery Disease Patients? (23109123)
2013
11
Salacia oblonga ameliorates hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. (22561158)
2012
12
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. (22135386)
2012
13
Management of hypertriglyceridemia in children with acute lymphoblastic leukemia under persistent therapy with glucocorticoids and L-asparaginase during induction chemotherapy. (22619026)
2012
14
Successful management of extreme hypertriglyceridemia from pegaspargase with omega-3. (22392609)
2012
15
Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. (22962670)
2012
16
Hypertriglyceridemia secondary to obesity and diabetes. (22005032)
2012
17
Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption. (21604764)
2011
18
Etiology and risk of lactescent plasma and severe hypertriglyceridemia. (21262505)
2011
19
The relative importance of common and rare genetic variants in the development of hypertriglyceridemia. (21615327)
2011
20
Patient characteristics and medical care costs associated with hypertriglyceridemia. (21211599)
2011
21
Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy. (21150557)
2011
22
Management of hypertriglyceridemia in the diabetic patient. (20532703)
2010
23
Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype. (20368524)
2010
24
Sirolimus-induced severe hypertriglyceridemia in a lung transplant recipient. (20177353)
2010
25
Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice. (19362162)
2009
26
Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. (19667310)
2009
27
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
28
Acute elevation of triglycerides after initiation of fosamprinavir/ritonavir in an HIV-negative patient with baseline hypertriglyceridemia. (21291769)
2008
29
Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver. (18357405)
2008
30
Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia. (17196967)
2008
31
Examination of the skin in hypertriglyceridemia. (18595869)
2008
32
Treating hypertriglyceridemia. (17846443)
2007
33
The role of hypertriglyceridemia in atherosclerosis. (17877919)
2007
34
Hypertriglyceridemia and cardiovascular risk reduction. (17697898)
2007
35
Hypertriglyceridemia and cardiovascular disease management. (18510282)
2007
36
Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia. (16940448)
2006
37
Priapism secondary to hypertriglyceridemia. (12576856)
2003
38
Insulin resistance but not hypertriglyceridemia per se is associated with endothelial dysfunction in chronic hypertriglyceridemia. (11827701)
2002
39
Apolipoprotein E1 Baden (Arg(180)-->Cys). A new apolipoprotein E variant associated with hypertriglyceridemia. (11163021)
2001
40
Lipoprotein lipase gene polymorphism and lipid profile in patients with hypertriglyceridemia. (11593500)
2001
41
Identification and treatment of hypertriglyceridemia as a risk factor for coronary heart disease. (10980847)
1999
42
Tumor necrosis factor alpha as a uremic toxin: correlation with neuropathy, left ventricular hypertrophy, anemia, and hypertriglyceridemia in peritoneal dialysis patients. (10682077)
1999
43
Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. (10606208)
1999
44
The TNF-beta gene Nco I polymorphism is not associated with hypertriglyceridemia or insulin resistance in lean and obese subjects. (9245742)
1997
45
Primary chylomicronemia in patients with severe familial hypertriglyceridemia responds to long-term treatment with (n-3) fatty acids. (7782902)
1995
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia. (8349676)
1993
48
Does familial hypertriglyceridemia predispose to NIDDM? (8299439)
1993
49
Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology and clinical course of hypertension. (1994722)
1991
50
Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. (1752964)
1991

Variations for Hypertriglyceridemia

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Expression for genes affiliated with Hypertriglyceridemia

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Search GEO for disease gene expression data for Hypertriglyceridemia.

Pathways for genes affiliated with Hypertriglyceridemia

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Pathways related to Hypertriglyceridemia according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7APOA1, APOB
29.6APOA1, APOA2
3
Show member pathways
9.6GPD1, LPIN3, LPIN2
4
Show member pathways
9.6GPD1, LPIN3, LPIN2
5
Show member pathways
9.6LPIN2, LPL, LPIN3
69.6LPIN2, LPL, LPIN3
7
Show member pathways
9.3APOE, APOB, APOA1
8
Show member pathways
fatty acid beta-oxidation VI (peroxisome)36
8.9APOA1, APOC3, APOA5, APOA2, LPL
9
Show member pathways
thioredoxin pathway36
8.9APOA1, APOB, LDLR
10
Show member pathways
8.3APOA5, GPD1, APOA1, APOA2, LPIN3, LPL
11
Show member pathways
7.3APOA1, APOC3, LPL, APOA2, APOC2, APOB
127.3APOA1, APOC3, APOA2, APOC2, APOB, LDLR
13
Show member pathways
7.3LPL, APOE, APOA1, APOC3, APOA2, LDLR
14
Show member pathways
6.5APOC2, LPL, CETP, APOE, APOA1, APOC3
15
Show member pathways
5.9APOA5, LPA, CETP, LDLR, APOB, APOC2
16
Show member pathways
4.3APOA5, LPIN3, LPA, CETP, LDLR, PON1

Compounds for genes affiliated with Hypertriglyceridemia

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Compounds related to Hypertriglyceridemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 308)
idCompoundScoreTop Affiliating Genes
1fenofibric acid44 2810.4LPL, APOA1, APOC3, APOB
2retinyl palmitate44 2410.2APOE, APOA1, APOB, LPL
3taurocholate449.1LPL, APOB, APOC3, SLC10A2, APOA1
47-ketocholesterol44 249.8APOE, PON1, APOB, APOA1
5lathosterol44 249.6CETP, APOE, LDLR, APOB
6betacarotene448.5PON1, APOB, APOE, CETP, LPL
7ciprofibrate44 289.4APOB, LDLR, APOA1, PON1, LPL
8vitamin b12448.4APOE, APOA1, APOB, PON1, LPA
9lycopene44 249.3LPL, CETP, LDLR, PON1
10dextran sulfate448.2LDLR, CETP, LPL, APOA1, APOB
11intralipid448.2APOA1, APOC3, LPL, CETP, APOB, APOA2
12xbai448.2APOC3, APOE, APOB, LDLR, CETP, LPL
13sele448.1LDLR, PON1, APOC3, APOE, CETP, LPL
14rosuvastatin44 50 28 1111.1APOB, CETP, LDLR, APOE, APOC3, APOA1
15rosiglitazone28 44 50 24 1112.1LPL, LPA, PON1, APOB, APOC3, APOE
16probucol44 119.0CETP, APOA1, APOE, APOB, LDLR, LPL
17dimyristoylphosphatidylcholine448.0APOA5, APOA2, LDLR, LPA, APOA1, APOE
18palmitate448.0CETP, LPL, APOA1, APOE, APOB, LDLR
19cholestyramine448.0LPA, APOB, APOC3, APOE, CETP, LDLR
20sterol447.9CETP, SLC10A2, LDLR, APOA1, APOB, APOE
21oleic acid44 28 24 1110.8LPL, GPD1, APOB, LDLR, CETP, LPA
22niacin44 118.8LPL, CETP, LDLR, APOB, APOA1, LPA
23homocysteine44 248.6APOE, APOC3, APOC2, APOB, PON1, CETP
24fluvastatin44 50 28 1110.5APOE, APOA1, APOB, PON1, LDLR, CETP
25alpha tocopherol447.5APOB, APOE, APOA1, PON1, LDLR, LPL
26mspi447.5APOA1, APOC3, APOA2, APOB, LDLR, CETP
27creatinine447.4PON1, APOC2, APOA1, APOE, APOC3, APOB
28aspirin44 50 28 2410.2APOA1, APOE, LDLR, PON1, APOB, CETP
29glucose447.1APOA5, APOA1, APOC3, APOA2, APOB, PON1
30testosterone44 60 24 1110.0PON1, APOE, APOA1, APOC3, APOB, LDLR
31glutamine447.0LDLR, APOB, PON1, APOA2, CETP, LPL
32thyroxine44 247.9APOE, LPL, LPA, APOA1, APOB, PON1
33bezafibrate44 28 118.8LPA, CETP, LDLR, APOB, LPL, APOA2
34fatty acid446.8APOB, LPA, GPD1, LPL, CETP, LDLR
35simvastatin44 50 60 28 24 1111.8PON1, LDLR, CETP, LPA, LPL, APOA5
36triacylglycerol446.7LDLR, CETP, LPL, APOB, APOC2, APOA2
37phospholipid446.7LPL, CETP, LDLR, APOE, APOA1, APOC3
38lovastatin44 50 60 28 1110.5APOE, APOA1, APOC3, APOA5, APOB, PON1
39phosphatidylcholine446.5APOE, APOA1, APOB, PON1, LDLR, CETP
40vitamin a44 24 118.5APOC2, APOB, PON1, LDLR, CETP, LPA
41pravastatin44 50 28 24 1110.5APOE, SLC10A2, LPL, LPA, CETP, LDLR
42serine446.4CETP, SLC10A2, APOB, APOE, APOA2, APOC3
43atorvastatin44 50 28 24 1110.3SLC10A2, LPL, LPA, CETP, LDLR, PON1
44cholesterol ester446.3LPL, LPA, CETP, LDLR, PON1, APOB
45heparin44 28 24 119.2APOC3, APOA5, APOA2, APOC2, APOB, PON1
46estrogen446.2APOA2, CETP, LDLR, PON1, APOB, LPL
47fenofibrate44 50 118.1APOB, LPL, LPA, CETP, LDLR, PON1
48gemfibrozil28 44 118.1APOB, APOC3, APOA1, APOE, APOC2, APOA2
49cholesterol44 28 24 118.6APOC2, APOB, PON1, LDLR, CETP, LPA
50lipid445.3CETP, LPA, LPL, SLC10A2, LDLR, PON1

GO Terms for genes affiliated with Hypertriglyceridemia

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Cellular components related to Hypertriglyceridemia according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:00343639.3APOB, APOC2, APOE, APOC3
2endocytic vesicle lumenGO:00716829.2APOA1, APOB, APOE
3endoplasmic reticulum lumenGO:00057889.2APOA2, APOA1, APOB
4spherical high-density lipoprotein particleGO:00343668.9APOA1, APOC3, APOA2, PON1, APOC2
5low-density lipoprotein particleGO:00343628.6APOA5, LDLR, APOB, APOC2, APOE
6chylomicronGO:00426278.5APOE, APOA5, LPL, APOC3, APOB, APOA2
7blood microparticleGO:00725628.5PON1, APOA2, APOA1, APOE
8high-density lipoprotein particleGO:00343648.3CETP, PON1, APOA2, APOA5, APOE, APOA1
9very-low-density lipoprotein particleGO:00343618.1APOC3, APOE, APOA1, APOA5, APOA2, APOC2
10early endosomeGO:00057697.7APOC3, APOE, LDLR, APOA2, APOC2, APOB
11extracellular spaceGO:00056157.1PON1, APOE, APOA1, APOC3, APOA5, APOC2
12extracellular regionGO:00055766.2APOC3, APOA1, APOA5, APOA2, APOC2, APOE

Biological processes related to Hypertriglyceridemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of very-low-density lipoprotein particle remodelingGO:001090210.4APOA5, APOC2
2negative regulation of lipid metabolic processGO:004583310.2APOC3, APOC2
3negative regulation of very-low-density lipoprotein particle clearanceGO:001091610.2APOC3, APOC2
4chylomicron remodelingGO:003437110.2APOC2, LPL
5negative regulation of cholesterol importGO:006062110.1APOA2, APOC3
6chylomicron remnant clearanceGO:003438210.0APOC2, APOC3, APOE
7positive regulation of triglyceride catabolic processGO:001089810.0APOC2, APOA5
8triglyceride-rich lipoprotein particle remodelingGO:003437010.0APOA2, APOC2, APOA5
9positive regulation of lipid catabolic processGO:005099610.0APOA2, APOA5
10negative regulation of cholesterol transportGO:003237510.0APOC2, APOA2
11lipoprotein transportGO:00429539.9APOC3, APOC2, APOB
12negative regulation of lipase activityGO:00601929.9APOA2, APOA1
13triglyceride biosynthetic processGO:00194329.9GPD1, LPL, LPIN2
14regulation of Cdc42 protein signal transductionGO:00324899.9APOE, APOA1, APOC3
15triglyceride mobilizationGO:00066429.9APOB, APOC3
16regulation of intestinal cholesterol absorptionGO:00303009.9APOA1, APOA2
17negative regulation of very-low-density lipoprotein particle remodelingGO:00109039.8APOA2, APOA1, APOC3
18negative regulation of cytokine secretion involved in immune responseGO:00027409.8APOA2, APOA1
19peripheral nervous system axon regenerationGO:00140129.8APOA1, APOE
20lipoprotein biosynthetic processGO:00421589.7APOA1, APOB, APOE
21triglyceride catabolic processGO:00194339.7APOC3, APOA5, APOB, LPL
22organ regenerationGO:00311009.7APOA5, APOA1, APOA2
23high-density lipoprotein particle assemblyGO:00343809.7APOE, APOA2, APOA1
24positive regulation of cholesterol esterificationGO:00108739.7APOA2, APOA1, APOE
25phospholipid metabolic processGO:00066449.6LPL, LPIN2, GPD1, LPIN3
26cholesterol importGO:00705089.6LDLR, APOA1
27protein oxidationGO:00181589.5APOA2, APOA1
28high-density lipoprotein particle clearanceGO:00343849.5APOE, APOA1, APOA2, APOC2
29very-low-density lipoprotein particle remodelingGO:00343729.5LPL, APOC2, CETP, APOE
30phosphatidylcholine biosynthetic processGO:00066569.5LPIN3, APOA2, APOA1, LPIN2
31lipid transportGO:00068699.4CETP, LPA, APOA5
32peptidyl-methionine modificationGO:00182069.3APOA1, APOA2
33lipoprotein catabolic processGO:00421599.3APOE, LDLR, APOB
34phospholipid effluxGO:00337009.3APOC2, APOC3, APOA1, APOE, APOA2
35cellular lipid metabolic processGO:00442559.2GPD1, APOA1, LPIN2, APOA2, APOA5
36response to drugGO:00424939.2APOA2, LPL, APOC2, APOA1, APOC3
37low-density lipoprotein particle remodelingGO:00343749.2CETP, APOA2, APOE, APOB
38triglyceride homeostasisGO:00703289.0APOC3, APOA1, APOA5, APOC2, CETP, LPL
39high-density lipoprotein particle remodelingGO:00343759.0APOA1, CETP, APOA2, APOC3, APOE
40cholesterol effluxGO:00333448.9APOE, APOA1, APOA2, APOC3, APOC2, APOB
41triglyceride metabolic processGO:00066418.8APOA5, APOC3, APOE, APOA2, CETP, LPL
42cholesterol transportGO:00303018.8APOB, CETP, APOA1, LDLR
43reverse cholesterol transportGO:00436918.8CETP, APOC2, APOA2, APOC3, APOA1, APOE
44receptor-mediated endocytosisGO:00068988.2CETP, LDLR, APOB, APOE, LPA
45cholesterol metabolic processGO:00082037.7CETP, APOB, APOA2, APOC3, APOA1, APOE
46phototransduction, visible lightGO:00076037.7APOE, APOA1, APOC3, APOA2, APOC2, APOB
47retinoid metabolic processGO:00015237.7APOB, APOC2, APOA1, APOA2, APOC3, LDLR
48cholesterol homeostasisGO:00426327.3APOA1, APOE, APOC3, APOA5, CETP, LDLR
49lipoprotein metabolic processGO:00421576.4LPL, LPA, CETP, LDLR, APOB, APOC2
50small molecule metabolic processGO:00442815.3SLC10A2, LPIN2, CETP, APOC3, APOA1, APOE

Molecular functions related to Hypertriglyceridemia according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein lipase activator activityGO:006023010.2APOC2, APOA5
2lipase bindingGO:003547310.0APOB, APOA5
3phospholipase activityGO:000462010.0LPL, LIPI
4triglyceride bindingGO:00171299.9LPL, CETP
5apolipoprotein receptor bindingGO:00341909.9APOA2, APOA1
6phosphatidate phosphatase activityGO:00081959.8LPIN2, LPIN3
7low-density lipoprotein particle receptor bindingGO:00507509.8APOA5, APOE, APOB
8beta-amyloid bindingGO:00015409.8APOA1, APOE
9high-density lipoprotein particle receptor bindingGO:00706539.7APOC3, APOA2, APOA1
10phospholipid transporter activityGO:00055489.7CETP, APOA1
11high-density lipoprotein particle bindingGO:00080359.6APOA1, APOA2
12phosphatidylcholine-sterol O-acyltransferase activator activityGO:00602289.6APOE, APOA1, APOA2
13phosphatidylcholine bindingGO:00312109.6APOA5, CETP, APOA2
14lipase inhibitor activityGO:00551029.5APOA1, APOC2, APOA2, APOC3
15lipid transporter activityGO:00053199.4CETP, APOA2, APOE
16apolipoprotein bindingGO:00341859.2LPA, LPL
17cholesterol bindingGO:00154859.2APOA1, APOC3, CETP, APOA2
18lipid bindingGO:00082899.0APOC2, APOE, APOA5, APOA2, CETP
19protein homodimerization activityGO:00428038.8GPD1, APOE, PON1, APOC2, APOA2
20cholesterol transporter activityGO:00171278.7APOE, APOA1, APOA2, APOB, CETP
21heparin bindingGO:00082018.7APOA5, APOE, LPL, LPA, LIPI, APOB
22phospholipid bindingGO:00055438.3APOB, APOA1, APOC3, APOA5, APOA2, PON1

Sources for Hypertriglyceridemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet