Hypertrophic Cardiomyopathy malady

Wikipedia: Hypertrophic cardiomyopathy (\"HCM\") is a primary disease of the myocardium (the muscle of the heart)...⁴⁴ more...

MalaCards: Hypertrophic Cardiomyopathy, also known as hypertrophic obstructive cardiomyopathy (disorder), is related to familial hypertrophic cardiomyopathy and familial dilated cardiomyopathy. An important gene associated with Hypertrophic Cardiomyopathy is MYBPC3 (myosin binding protein C, cardiac), and among its related pathways are Prostate cancer and Glioma. The compounds retinoic acid and lipid have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skeletal muscle, and related mouse phenotypes are skeleton and growth/size.

Aliases & Descriptions:

hypertrophic cardiomyopathy 6 8 43 hypertrophic obstructive cardiomyopathy (disorder) 6 primary hypertrophic cardiomyopathy (disorder) 6 hypertrophic obstructive cardiomyopathy 6 cardiomyopathy hypertrophic obstructive 32

hypertrophic cardiomyopathy (disorder) 6 cardiomyopathy, hypertrophic 6 hyper. obst. cardiomyopathy 6 hypertrophic myocardiopathy 6 cardiomyopathies 43

Diseases related to hypertrophic cardiomyopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 996)

id	Related Disease	Score	Top Affiliating Genes
1	familial hypertrophic cardiomyopathy	42.7	VCL, MYBPC3, MYLK2, MYOZ2, MYBPC1, MYBPC2
2	familial dilated cardiomyopathy	34.6	LMNA, MYOZ2, MEF2A, GJA1, TPM1, TNNC1
3	hypertension	33.8	REN, CYP11B2, NOS3, ACE, AGT, AGTR1
4	arrhythmogenic right ventricular dysplasia	33.8	MYOZ2, FKBP1B, ACE, NPPB, RYR2
5	muscular dystrophy	33.5	PIK3C2A, SGCD, LMNA, CHKB, FKTN, ANKRD1
6	familial restrictive cardiomyopathy	32.8	TNNI3, TTR, DES, NPPB, MYH7
7	danon disease	32.7	LAMP2, MPP2, GLA, PRKAG2, GAA
8	wolff-parkinson-white syndrome	32.2	MYBPC1, PRKAA2, PRKAG2, MYH7
9	myocarditis	31.2	PIK3C2A, SGCD, SELP, MYBPC1, MYOCD, CHKB
10	leopard syndrome	31.1	BRAF, RAF1, MAP2K2, MAP2K1, HRAS, PTPN11
11	nemaline myopathy	30.7	TPM1, TPM2, TPM3, TNNT1, ACTA1, DES
12	glycogen storage disease	30.7	VWF, CHKB, LAMP2, MPP2, INS, IGF2
13	costello syndrome	30.6	BRAF, INS, MAP2K2, MAP2K1, IGF2, IGFBP3
14	chagas disease	30.6	MT-CO3, MT-CYB, IL6, CCL2, GNAI1, GNAS
15	fabry disease	30.6	VWF, IL6, GLA, TNF, NOS3, ACE
16	mitochondrial cardiomyopathy	30.6	COA5, MRPL3, CS, AARS2
17	hemochromatosis	30.4	MT-CYB, FXN, CALR, HLA-B, CP
18	noonan syndrome	30.4	BRAF, RAF1, MAP2K2, MAP2K1, IGFBP3, IGF1
19	hypertensive heart disease	30.2	CD36, ANXA5, TPM1, CYP11B2, NR3C2, ACE
20	left ventricular noncompaction	30.1	LMNA, MYBPC3, MT-ND1, FKBP1B, TPM1, TNNT2
21	myofibrillar myopathy	30.1	LMNA, FHL1, TCAP, DES, PRKCA
22	sudden cardiac death multi-gene panels	30.0	LMNA, MYBPC3, FKBP1B, HTR2A, CAV3, CALR
23	ventricular fibrillation	29.9	SELP, CHKB, ATP2A2, FKBP1B, GLA, TNNT2
24	spasticity	29.9	SGCD, MT-ND1, INS, ANXA5, HTR2A, GJA1
25	lactic acidosis	29.7	SCO2, MT-CO3, MT-ND1, AUH, COX5A, NDUFS4
26	ischemic heart disease	29.6	PIK3C2A, RETN, SELP, VCL, CHKB, FABP3
27	dmd-associated dilated cardiomyopathy	29.6	PIK3C2A, REN, SGCD, VWF, VCL, LMNA
28	conduction disease	29.4	PIK3C2A, LMNA, DMPK, PRKAG2
29	becker muscular dystrophy	29.2	VCL, MYOZ2, CHKB, ALB, DYT10, DES
30	congestive heart failure	29.2	PIK3C2A, REN, CHKB, MUC16, FABP3, GNAI1
31	limb-girdle muscular dystrophy	28.9	PIK3C2A, LMNA, FKTN, CAV3, TTN, TCAP
32	vacuolar myopathy	28.9	LAMP2, MPP2, CAV3, GAA
33	aldosteronism	28.6	REN, RETN, MYBPC3, RAF1, CMA1, CD36
34	cataract	28.4	LMNA, MT-CYB, AUH, ATP2A2, CD36, INS
35	motor neuron disease	28.4	MT-CO1, AR, INS, IGF1, TNF, COX5A
36	hepatitis	28.3	SELP, ALB, PDGFB, TIMP2, TGFB1, SLC17A5
37	hearing loss	28.2	MYO6, MT-CO1, MT-ND1, CD36, GLA, GJA1
38	myopathy	28.1	PIK3C2A, COA5, VDAC1, LMNA, MYOZ2, MYBPC1
39	hypotonia	28.1	COA5, LMNA, SCO1, MT-CO1, MT-CO2, MT-CO3
40	atrial fibrillation	27.8	PIK3C2A, REN, RETN, VWF, SELP, LMNA
41	pulmonary embolism	27.7	PIK3C2A, INS, FABP3, ALB, HLA-B, TNNC1
42	endocardial fibroelastosis	27.6	CSRP3, NPPA, NPPB, MYH7
43	myocardial infarction	27.6	MMP2, ESR1, ACE, THBD
44	duchenne muscular dystrophy	27.6	PIK3C2A, SGCD, VCL, MYOZ2, CHKB, FKTN
45	lipodystrophy	27.6	RETN, LMNA, INS, IL6, CCL2, IGFBP1
46	congenital heart defect	27.6	PTPN11, EDN1, NPPA, NPPB, ADM, GATA4
47	pericarditis	27.5	PIK3C2A, REN, IL6, ALB, TNF, TNNI3
48	liver cirrhosis	27.3	REN, RETN, RAF1, IGFBP3, ALB, HRAS
49	spinal muscular atrophy	27.2	LMNA, SCO2, COX5A, NDUFS4, GAA
50	mitochondrial encephalomyopathy	27.1	SCO2, MT-CO1, COX15, NDUFAF1, CS

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypertrophic cardiomyopathy:

²²

MGI Mouse Phenotypes related to hypertrophic cardiomyopathy:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	INF	COL1A2, CYP19A1, PTPN11, ESR2, ESR1,
2	growth/size phenotype	MP:0005378	INF	COL1A2, SLC22A5, SLC6A4, RYR2, ADIPOQ, GAA
3	mortality/aging	MP:0010768	INF	VWF, SELP, , VDAC1, VCL, LMNA
4	hematopoietic system phenotype	MP:0005397	INF	GATA4, , PDGFB, COL1A1, SMC1A, GJA1
5	vision/eye phenotype	MP:0005391	INF	, PDGFB, COL1A1, NOS3, PTPN11, NDUFS4
6	nervous system phenotype	MP:0003631	INF	TIMP2, AGTR2, AGT, EDN1, NDUFS4,
7	renal/urinary system phenotype	MP:0005367	INF	AR, INS, MEF2C, GNAS, GLA, HRAS
8	normal phenotype	MP:0002873	INF	NDUFS4, , PDLIM3, COL1A2, COL1A1, CYP19A1
9	tumorigenesis	MP:0002006	INF	COL1A1, , ACE, ACADVL, AGTR2, TGFB1
10	embryogenesis phenotype	MP:0005380	INF	PTPN11, COL1A1, , TTN, PRKACA, SOS1
11	behavior/neurological phenotype	MP:0005386	INF	MYO6, SCO2, CHKB, ATP2A2, FXN, INS
12	immune system phenotype	MP:0005387	INF	, COL1A1, SMC1A, CYP19A1, PTPN11, NDUFS4
13	digestive/alimentary phenotype	MP:0005381	INF	COL1A1, NOS3, PPARGC1A, ESR2, COL3A1,
14	integument phenotype	MP:0010771	INF	COL1A2, COL3A1, , NDUFS4, SOS1, POMC
15	respiratory system phenotype	MP:0005388	10.3	NDUFS4, ACE2, CSRP3, GATA4, MYL2, PDGFB
16	craniofacial phenotype	MP:0005382	9.7	PTPN11, EDN1, TTN, SOS1, PMM2, GJA1
17	liver/biliary system phenotype	MP:0005370	8.7	FABP3, IGFBP1, GLA, ESR2, CYP19A1, PPARGC1A
18	no phenotypic analysis	MP:0003012	8.2	PDGFB, EDN2, ACTN1, HCN4, SOS1, POMC
19	adipose tissue phenotype	MP:0005375	INF	TNF, PTPN11, CYP19A1, PPARGC1A, NOS3, COL1A1
20	cellular phenotype	MP:0005384	INF	VWF, SELP, , VCL, LMNA, RAF1
21	muscle phenotype	MP:0005369	INF	NOS3, TCAP, PVALB, DES, PRKAA2, PRKD1
22	cardiovascular system phenotype	MP:0005385	INF	AGTR1, CP, ADM, ADIPOQ, GATA4, GAA
23	homeostasis/metabolism phenotype	MP:0005376	INF	NPPA, SLPI, SLC25A4, SLC3A1, SLC17A5, SLC22A5
24	endocrine/exocrine gland phenotype	MP:0005379	INF	, CYP11B2, GJA1, GNAS, HTR2A, FKBP1B
25	reproductive system phenotype	MP:0005389	INF	ESR2, TNF, PTPN11, PDGFB, , AGT

Articles related to hypertrophic cardiomyopathy:

(show top 50)    (show all 458)

id	Title	Authors	Year	Affiliating Genes
1	Analysis of the Z-disc genes PDLIM3 and MYPN in patie nts with hypertrophic cardiomyopathy. (20801532)	Bagnall R.D.... Semsarian C.	2010	PDLIM3, MYPN
2	Identification of a novel MYBPC3 gene variant in a pa tient with hypertrophic cardiomyopathy. (20689143)	Brion M.... Rubattu S.	2010	MYBPC3
3	Prevalence and spectrum of mutations in a cohort of 1 92 unrelated patients with hypertrophic cardiomyopathy. (20624503)	Millat G.... Rousson R.	2010	MYH7
4	The R820W mutation in the MYBPC3 gene, associated wit h hypertrophic cardiomyopathy in cats, causes hypertrophic cardiomyopathy and l eft ventricular non-compaction in humans. (20542340)	Ripoll Vera T.... Torres MarquAcs J.	2010	MYBPC3
5	Hypertrophic cardiomyopathy. A study of the troponin- T gene in 127 Spanish families. (20038417)	Gimeno J.R.... ValdAcs M.	2009	TNNT2, TNNT1
6	Impact of QT variables on clinical outcome of genotyped hypertrophic cardiomyopathy. (19149795)	Uchiyama K.... Yamagishi M.	2009	MYH7
7	Diastolic abnormalities as the first feature of hypertrophic cardiomyopathy in Dutch myosin-binding protein C founder mutations. (19356534)	Michels M.... ten Cate F.J.	2009	MYBPC3
8	Evidence from human myectomy samples that MYBPC3 muta tions cause hypertrophic cardiomyopathy through haploinsufficiency. (19574547)	Marston S.... Watkins H.	2009	MYBPC3, MYBPC2
9	Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy. (18560893)	van der Merwe L.... Moolman-Smook J.C.	2008	ACE2
10	Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. (18505755)	Geier C.... Ozcelik C.	2008	CSRP3
11	Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy. (18374358)	Govada L.... Squire J.M.	2008	MYBPC3, MYBPC2
12	Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. (18830417)	Kerkela R.... Huggins G.S.	2008	GATA4
13	Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. (17652099)	Daw E.W.... Marian A.J.	2007	FAM188A
14	Altered expression of early cardiac marker genes in circulating cells of patients with hypertrophic cardiomyopathy. (18005871)	Kontaraki J.E.... Vardas P.E.	2007	MEF2C, GATA4, MYOCD
15	Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy. (17476457)	Matsushita Y.... Matsuoka R.	2007	JPH2
16	Cardiac natriuretic peptides in patients with hypertrophic cardiomyopathy (18260860)	Safrygina I.u.V.... Belenkov I.u.N.	2007	NPPA
17	Mutation of the MYH7 gene in a child with hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome. (17495353)	Bobkowski W.... Siwinska A.	2007	MYH7
18	Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy. (17885214)	Ripplinger C.M.... Efimov I.R.	2007	GJA1
19	Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc. (16949038)	Vasile V.C.... Ackerman M.J.	2006	VCL
20	Familial hypertrophic cardiomyopathy--a case report (17165166)	Domal-Kwiatkowska D.... Wodniecki J.	2006	MYH7
21	Combined effects of low-dose spironolactone and capto pril therapy in a rat model of genetic hypertrophic cardiomyopathy. (17204904)	de Resende M.M.... Greene A.S.	2006	ACE
22	Valsartan decreases type I collagen synthesis in patients with hypertrophic cardiomyopathy. (16195625)	Kawano H.... Yano K.	2005	AGTR1, NPPB
23	Hypertrophic cardiomyopathy linked to homozygosity for a new mutation in the myosin-binding protein C gene (A627V) suggests a dosage effect. (16004897)	Garcia-Castro M.... Coto E.	2005	MYBPC3
24	Circulating levels of heart-type fatty acid-binding protein and its relation to thallium-201 perfusion defects in patients with hypertrophic cardiomyopathy. (15904639)	Morioka N.... Higaki J.	2005	FABP3
25	Lifelong left ventricular remodeling of hypertrophic cardiomyopathy caused by a founder frameshift deletion mutation in the cardiac Myosin-binding protein C gene among Japanese. (16256878)	Kubo T.... Doi Y.L.	2005	MYBPC2
26	Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. (15698845)	Doolan A.... Semsarian C.	2005	TNNI3
27	A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathy. (15889278)	Takahashi K.... Ozono K.	2005	PTPN11
28	F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers. (16115869)	Hernandez O.M.... Potter J.D.	2005	TNNT2
29	Frequency and clinical expression of cardiac troponin I mutations in 748 consecutive families with hypertrophic cardiomyopathy. (15607392)	Mogensen J.... McKenna W.J.	2004	TNNI3
30	Phosphorylation of human cardiac troponin I G203S and K206Q linked to familial hypertrophic cardiomyopathy affects actomyosin interaction in different ways. (14596793)	Deng Y.... Thieleczek R.	2003	TNNI3, PRKCA
31	Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis. (12975413)	Woo A.... Sole M.J.	2003	MYH7
32	Hypertrophic cardiomyopathy: two homozygous cases with 'typical' hypertrophic cardiomyopathy and three new mutations in cases with progression to dilated cardiomyopathy. (12951062)	Nanni L.... Lanfranchi G.	2003	MYH7
33	Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly. (11815426)	Niimura H.... Seidman C.E.	2002	MYH6
34	Association between aldosterone synthase gene polymorphism and hypertrophic cardiomyopathy (12376254)	Chen A.H.... Sun J.Z.	2002	CYP11B2
35	Relation between angiotensin-converting enzyme II genotype and atrial fibrillation in Japanese patients with hypertrophic cardiomyopathy. (12166654)	Ogimoto A.... Hiwada K.	2002	ACE
36	Determinants and clinical significance of natriuretic peptides and hypertrophic cardiomyopathy. (11465965)	Briguori C.... Chiariello M.	2001	NPPB
37	Molecular genetics and pathogenesis of hypertrophic cardiomyopathy. (11740432)	Marian A.J.... Lutucuta S.	2001	MYBPC1
38	Spectrum of clinical phenotypes and gene variants in cardiac myosin- binding protein C mutation carriers with hypertrophic cardiomyopathy. (11499719)	Erdmann J.... Regitz-Zagrosek V.	2001	MYBPC3
39	Beta-myosin heavy chain gene mutations and hypertrophic cardiomyopathy in Austrian children. (11133230)	Greber-Platzer S.... Wimmer M.	2001	MYH7
40	Reduced myocardial sarcoplasmic reticulum Ca(2+)-ATPase mRNA expression and biphasic force-frequency relations in patients with hypertrophic cardiomyopathy. (11489771)	Somura F.... Yokota M.	2001	ATP2A2, RYR2
41	Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy. (10806205)	Elliott K.... Redwood C.S.	2000	TNNI3, TNNC1
42	Familial hypertrophic cardiomyopathy: a paradigm of the cardiac hypertrophic response to injury. (9800880)	Marian A.J.... Roberts R.	1998	MYBPC3
43	Genetic causes of hypertrophic cardiomyopathy (9594535)	Vosberg H.P.	1998	MYBPC1
44	Prognostic significance of beta-myosin heavy chain mutations is reflective of their hypertrophic expressivity in patients with hypertrophic cardiomyopathy. (9154300)	Abchee A.... Marian A.J.	1997	MYH6
45	Overexpression of transforming growth factor-beta1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy. (9264495)	Li R.K.... Williams W.G.	1997	TGFB1, IGF1, IGF2
46	Identification of a mutation near a functional site of the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy. (7815466)	Dufour C.... Schwartz K.	1994	MYH7
47	Identification of a new missense mutation at Arg403, a CpG mutation hotspot, in exon 13 of the beta-myosin heavy chain gene in hypertrophic cardiomyopathy. (8268932)	Moolman J.C.... Corfield V.A.	1993	MYH7
48	A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3. (7981753)	Watkins H.... Seidman C.E.	1993	TNNT2
49	Persistent elevation of cardiac enzymes in a patient with hypertrophic cardiomyopathy--with special reference to electrocardiographi c, echocardiographic and 201-thallium myocardial scintigraphic findings. (2398616)	Hamada M.... Kokubu T.	1990	PIK3C2A
50	A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. (2144212)	Tanigawa G.... Seidman C.E.	1990	MYH6

Genes related to hypertrophic cardiomyopathy according to GeneCards:

(show top 50)    (show all 164)

id	Symbol	Description	Score	GeneCards Section Context
1	MYBPC3	myosin binding protein C, cardiac	11.1	Publications, Summaries
2	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.1	Publications, Summaries
3	TNNI3	troponin I type 3 (cardiac)	11.1	Publications, Summaries
4	TNNT2	troponin T type 2 (cardiac)	11.1	Summaries, Publications
5	MYL2	myosin, light chain 2, regulatory, cardiac, slow	11.1	Summaries, Publications
6	MYBPC2	myosin binding protein C, fast type	11.1	Summaries, Publications
7	MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	11.1	Summaries, Publications
8	TPM1	tropomyosin 1 (alpha)	11.1	Summaries, Publications, Orthologs
9	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	11.1	Publications, Summaries
10	CALR3	calreticulin 3	11.1	Publications, Summaries
11	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	11.1	Publications, Summaries
12	MYH6	myosin, heavy chain 6, cardiac muscle, alpha	11.1	Summaries, Publications, Pathways & Interactions
13	ACTC1	actin, alpha, cardiac muscle 1	11.1	Summaries, Publications
14	TTN	titin	11.1	Publications, Summaries
15	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	11.1	Publications, Summaries
16	MYO6	myosin VI	11.0	Publications
17	TNNC1	troponin C type 1 (slow)	11.0	Publications
18	PLN	phospholamban	11.0	Publications
19	MYBPC1	myosin binding protein C, slow type	11.0	Publications
20	SLN	sarcolipin	11.0	Publications
21	TCAP	titin-cap (telethonin)	11.0	Publications
22	MYBPH	myosin binding protein H	11.0	Publications
23	TNNT1	troponin T type 1 (skeletal, slow)	11.0	Publications
24	TPM2	tropomyosin 2 (beta)	11.0	Orthologs
25	FKBP1B	FK506 binding protein 1B, 12.6 kDa	11.0	Publications
26	NEXN	nexilin (F actin binding protein)	11.0	Publications
27	TPM4	tropomyosin 4	11.0	Orthologs
28	PEX6	peroxisomal biogenesis factor 6	11.0	Publications
29	MYOZ2	myozenin 2	11.0	Publications
30	CAV3	caveolin 3	11.0	Publications
31	SRI	sorcin	11.0	Publications
32	TPM3	tropomyosin 3	11.0	Orthologs
33	NPPB	natriuretic peptide B	11.0	Publications
34	VCL	vinculin	11.0	Publications
35	JPH2	junctophilin 2	11.0	Publications
36	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	11.0	Publications
37	CASQ2	calsequestrin 2 (cardiac muscle)	11.0	Publications
38	CALM3	calmodulin 3 (phosphorylase kinase, delta)	11.0	Publications
39	FXN	frataxin	11.0	Publications
40	CALR	calreticulin	11.0	Publications
41	ACTN1	actinin, alpha 1	11.0	Publications
42	PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit	11.0	Publications
43	AGTR1	angiotensin II receptor, type 1	11.0	Publications
44	DNAH8	dynein, axonemal, heavy chain 8	11.0	Publications
45	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
46	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
47	TRA@	T cell receptor alpha locus	11.0	Publications
48	PRKCA	protein kinase C, alpha	11.0	Publications
49	DYT10	dystonia 10	11.0	Publications
50	MT-TV	mitochondrially encoded tRNA valine	11.0	Publications

Pathways related to hypertrophic cardiomyopathy according to GeneDecks:

(show top 50)    (show all 302)

id	Pathway	Score	Top Affiliating Genes
1	Prostate cancer20	INF	IGF1, , RAF1, AR, HRAS, PDGFB
2	Glioma20	INF	CALM3, HRAS, , PDGFB, SOS1, IGF1
3	Long-term depression20	INF	RAF1, MAP2K2, MAP2K1, IGF1, GNAI1, GNAS
4	Focal adhesion20	INF	, VCL, VWF, , CAV3, RAF1
5	Insulin signaling pathway20	INF	INS, MAP2K1, MAP2K2, RAF1, , CALM3
6	Adipocytokines & Insulin Signaling37	INF	PRKAA2, , SOS1, PTPN11, MAP2K2, INS
7	Striated Muscle Contraction38	11.5	MYL3, MYL2, MYH6, TCAP, TTN, ACTA1
8	Epithelial Adherens Junctions36	10.7	HRAS, IGF2, MYO6, PTPN11, PPBP, PDGFB
9	ACE Inhibitor Pathway, Pharmacodynamics34	10.6	AGTR1, CMA1, NR3C2, ACE2, AGTR2
10	Renin-angiotensin system20	10.6	ACE, REN, CMA1, AGT, AGTR1, AGTR2
11	Development Beta-adrenergic receptors signaling via cAMP10	10.6	GNAS, CALM3, TNNC1, TNNI3, TNNT2, PPARGC1A
12	Development_Beta-adrenergic receptors signaling via cAMP41	10.5	GNAS, CALM3, RYR2, PRKACA, PLN, PPARGC1A
13	Development_Endothelin-1/EDNRA signaling41	10.4	EDN1, NPPB, SOS1, GATA4, HRAS, CALM3
14	Renal cell carcinoma20	10.3	RAF1, MAP2K2, PDGFB, HRAS, SOS1
15	Development Endothelin-1/EDNRA signaling10	10.2	GNAI1, MAP2K2, RAF1, MAP2K1, NPPB, SOS1
16	Development PDGF signaling via MAPK cascades10	10.1	HRAS, MAP2K1, MAP2K2, RAF1, GNAS, SOS1
17	Development_PDGF signaling via MAPK cascades41	10.1	PRKACA, PRKCA, PDGFB, SOS1, HRAS, RAF1
18	CREB Pathway36	9.9	SOS1, GNAI1, PRKCA, PRKACA, PPBP, CALM3
19	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.9	KNG1, TGFB1, AGTR2, AGTR1, AGT, ACE2
20	Development Ligand-independent activation of ESR1 and ESR210	9.7	PRKACA, ESR2, SOS1, HRAS, ESR1, GNAS
21	NFAT and Cardiac Hypertrophy36	9.6	CALM3, MAP2K2, RAF1, GATA4, SOS1, PRKCA
22	Dilated cardiomyopathy20	9.5	TPM4, TPM3, TPM2, TPM1, GNAS, ATP2A2
23	Development_Ligand-independent activation of ESR1 and ESR241	9.4	ESR2, MAP2K2, MAP2K1, IGF1, GNAS, HRAS
24	Hypertrophic cardiomyopathy (HCM)20	9.3	RYR2, PRKAG2, PRKAA2, DES, TGFB1, ACTC1
25	eNOS Signaling36	9.1	ESR1, TIMP2, IGF2, ACTA1, GNAI1, PDGFB
26	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.0	COL1A1, PRKD1, PRKACA, PRKCA, TNF, IGF1
27	Phospholipase-C Pathway36	8.9	PDGFB, TIMP2, PRKCA, SOS1, TGFB1, COL3A1
28	Renin-Angiotensin Pathway36	8.7	AGTR1, REN, AGT, RAF1, IL6, PRKCA
29	Antioxidant Action of Vitamin-C36	8.4	PDGFB, ACTA1, TGFB1, PRKACA, PRKCA, MYH6
30	PAK Pathway36	8.3	MYL7, PPBP, TNF, IGF1, IGF2, CCL2
31	Beta-Adrenergic Signaling36	INF	, RAF1, ATP2A2, PRKACA, PLN, TNNI1
32	Activation of PKA through GPCR36	INF	NOS3, PDGFB, PLN, PPBP, TNNI3, TNNI1
33	MAPK Signaling36	INF	TNF, COL3A1, VCL, HRAS, SOS1, PRKCA
34	Estrogen Pathway36	INF	PPARGC1A, PPBP, NOS3, PDGFB, TIMP2, TGFB1
35	Immune response CCR3 signaling in eosinophils10	INF	MYH7, , RAF1, MAP2K2, MAP2K1, CALM3
36	Signaling Involved in Cardiac Hypertrophy36	INF	PRKACA, TGFB1, PRKCA, AGTR2, ACTA1, HRAS
37	Development G-Proteins mediated regulation MARK-ERK signaling10	INF	GNAI1, SOS1, HRAS, CALM3, GNAS, MAP2K1
38	Calcium signaling pathway20	INF	VDAC1, SLC25A4, PRKCA, PRKACA, AGTR1, NOS3
39	cAMP Pathway36	INF	IGF1, IGF2, MAP2K1, MAP2K2, IL6, RAF1
40	Gap junction20	INF	GNAS, RAF1, MAP2K2, MAP2K1, HTR2A, SOS1
41	GPCR Pathway36	INF	HRAS, PPBP, PDGFB, TIMP2, TGFB1, PRKACA
42	ERK Signaling36	INF	TIMP2, GNAI1, MAP2K1, IGF2, PRKCA, SOS1
43	Activation of cAMP-Dependent PKA36	INF	TNNI1, HRAS, CALM3, GNAI1, IGF1, IGF2
44	Immune response _CCR3 signaling in eosinophils41	INF	PRKCA, , MYL3, MYL2, MYH7, MYH6
45	VEGF and S-1P Signaling36	INF	HRAS, PIK3C2A, CALM3, MAP2K1, MAP2K2, RAF1
46	Cardiac muscle contraction20	INF	MYL3, , , , ,
47	PTEN Pathway36	INF	MAP2K2, SOS1, ACTA1, PDGFB, COL3A1, COL1A2
48	Development_G-Proteins mediated regulation MARK-ERK signaling41	INF	HRAS, , RAF1, MAP2K2, GNAS, CALM3
49	Melanogenesis20	INF	MAP2K1, POMC, RAF1, MAP2K2, EDN1, PRKCA
50	GnRH signaling pathway20	INF	SOS1, PRKCA, PRKACA, , HRAS, GNAS

Compounds related to hypertrophic cardiomyopathy according to GeneDecks:

(show top 50)    (show all 434)

id	Compound	Score	Top Affiliating Genes
1	retinoic acid32 42 18	INF	VWF, SELP, , LMNA, MYOCD, RAF1
2	lipid32	INF	PIK3C2A, RETN, , VDAC1, VCL, LMNA
3	glucose32	INF	, VCL, , MUC16, ,
4	atp32	INF	PIK3C2A, , VDAC1, VCL, LMNA, MYBPC3
5	calcium32 9 18 9	INF	PIK3C2A, REN, RETN, VWF, , VDAC1
6	alanine32	INF	PIK3C2A, RETN, VWF, , LMNA,
7	potassium32 9 18 9	INF	PIK3C2A, REN, , VDAC1, CHKB,
8	fatty acid32	INF	PIK3C2A, RETN, , , INS, MEF2A
9	nitric oxide32 9 18 9	INF	REN, RETN, SELP, VDAC1, VCL,
10	citrate32	INF	PIK3C2A, SELP, VDAC1, CHKB, ,
11	paraffin32	INF	VWF, , BIRC5, CMA1, CHKB, MUC16
12	estrogen32	INF	RETN, VWF, SELP, , RAF1, BIRC5
13	aspartate32	INF	PIK3C2A, RETN, SELP, , RAF1, CHKB
14	forskolin32 42 9 9	INF	REN, RETN, , RAF1, MAP2K1, IGFBP1
15	ryanodine32	10.5	ATP2A2, JPH2, FKBP1B, CALR, CASQ2, GJA1
16	phenylephrine32 9 18 9	13.1	RAF1, AR, MEF2A, MAP2K1, GNAI1, CAV3
17	carvedilol32 34 9 9	12.6	REN, FKBP1B, GJA1, NOS3, NDUFS4, EDN1
18	verapamil32 34 9 18 9	13.5	REN, GJA1, DYT10, PPBP, EDN1, ACE
19	acetylcholine32 9 18 9	12.4	PIK3C2A, VWF, VCL, MYOZ2, RAF1, GNAI1
20	glycogen32 18	10.0	PIK3C2A, RETN, VDAC1, CHKB, LAMP2, ATP2A2
21	estradiol32 9 18 9	11.8	REN, BIRC5, CHKB, AR, MAP2K1, IGFBP1
22	procollagen32	8.8	CMA1, CFP, CD36, MMP2, IGFBP3, IGF1
23	testosterone32 9 18 9	11.8	PIK3C2A, VCL, RAF1, BIRC5, CHKB, MUC16
24	valsartan32 42 9 9	11.8	REN, SELP, CCL2, ALB, EDN1, ACE
25	homocysteine32 18	9.6	PIK3C2A, RETN, VWF, SELP, CCL2, ALB
26	histamine32 18	9.6	VWF, SELP, RAF1, CMA1, MAP2K1, CCL2
27	ramipril32 9 9	10.5	REN, INS, ALB, ACE, ACE2, AGTR1
28	adenylate32	8.4	VWF, SELP, VDAC1, CHKB, AR, IGF2
29	aspirin32 34 18	10.3	VWF, SELP, RAF1, BIRC5, CHKB, MMP2
30	doxorubicin32 34 9 9	11.2	PIK3C2A, RAF1, BIRC5, MUC16, AR, ANXA5
31	tamoxifen32 34 9 9	11.2	RAF1, BIRC5, CHKB, AR, IGFBP1, IGF2
32	epinephrine32 9 18 9	11.2	PIK3C2A, REN, SELP, CHKB, MMP2, INS
33	simvastatin32 34 42 9 18 9	12.8	PIK3C2A, VWF, SELP, CHKB, IL6, ANXA5
34	atorvastatin32 34 9 18 9	11.8	PIK3C2A, RETN, VWF, SELP, CHKB, MMP2
35	fibrinogen32	7.4	PIK3C2A, RETN, SELP, VCL, CHKB, INS
36	losartan32 34 9 9	10.0	REN, VWF, SELP, CD36, CCL2, IGFBP3
37	cyclosporin a32 42	7.7	PIK3C2A, VWF, SELP, VDAC1, RAF1, CHKB
38	indomethacin32 9 9	8.6	REN, RAF1, BIRC5, IL6, ANXA5, MAP2K1
39	genistein32 9 18 9	9.0	SELP, RAF1, BIRC5, CD36, MMP2, AR
40	dexamethasone32 42 34 9 9	8.1	REN, RETN, VWF, SELP, RAF1, BIRC5
41	cysteine32	INF	SELP, VDAC1, VCL, RAF1, CMA1, CHKB
42	heparin32 9 18 9	INF	PIK3C2A, VWF, VCL, RAF1, CMA1, CHKB
43	vitamin d32	INF	CHKB, CD36, AR, IL6, CCL2, IGFBP1
44	sb 20358032 42	INF	, BIRC5, CD36, MMP2, IL6, ANXA5
45	arginine32	INF	PIK3C2A, REN, VWF, , MYBPC3, CHKB
46	glutamate32	INF	, VDAC1, MPP2, MMP2, AR, INS
47	oxygen32 18	INF	PIK3C2A, VDAC1, BIRC5, SCO2, CHKB,
48	phosphoinositide32	INF	PIK3C2A, , VCL, RAF1, BIRC5, MAP2K2
49	ribonucleic acid32	INF	, ATP2A2, MMP2, CCL2, IGFBP1, IGF2
50	cholesterol32 9 18 9	INF	PIK3C2A, REN, RETN, VWF, SELP, LMNA

Cellular components related to hypertrophic cardiomyopathy according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	troponin complex	GO:005861	10.9	TNNT2, TNNT1, TNNI3, TNNI1, TNNC1
2	myosin filament	GO:032982	10.9	MYH7, MYH6, MYBPH, MYBPC2, MYBPC1
3	muscle thin filament tropomyosin	GO:005862	10.9	TPM1, TPM2, TPM3, TPM4
4	I band	GO:031674	10.8	MYPN, ANKRD1, ACTC1, TTN, MYL3
5	myofibril	GO:030016	10.6	MYL2, MYH6, OBSCN, NRAP, MYBPC1
6	sarcoplasmic reticulum	GO:016529	10.6	RYR2, SLN, AGL, PLN, CASQ2, ATP2A2
7	striated muscle thin filament	GO:005865	10.6	TTN, ACTA1, TNNT2
8	fascia adherens	GO:005916	10.5	VCL, GJA1, NRAP, DES
9	stress fiber	GO:001725	10.4	MYH7, MYH6, ACTA1, TPM4, TPM3, TPM1
10	sarcoplasmic reticulum membrane	GO:033017	10.4	RYR2, SLN, SRI, DMPK, ATP2A2
11	Z disc	GO:030018	10.4	MYL9, MYH6, MYH7, NEXN, RYR2, MYPN
12	muscle myosin complex	GO:005859	10.1	MYL9, MYH6, MYH7, MYL3
13	platelet alpha granule lumen	GO:031093	9.2	KNG1, TGFB1, ACTN1, PDGFB, PPBP, ALB
14	extracellular region	GO:005576	6.0	TTR, AGTR2, AGT, ACTN1, ACE2, EDN2
15	extracellular space	GO:005615	5.3	MMP2, EDN1, EDN2, ACE, ACE2, AGT
16	sarcomere	GO:030017	INF	MYBPC3, , MYOZ2, TPM1, TNNI3, TNNT2
17	mitochondrion	GO:005739	INF	, , NDUFS4, NDUFV2, ACADVL,
18	cytosol	GO:005829	INF	PIK3C2A, MAP2K2, MAP2K1, GNAS, CALM3, CALR
19	membrane raft	GO:045121	INF	SLC6A4, PRKCA, ACE2, , TNF, GJA1
20	mitochondrial inner membrane	GO:005743	INF	, SLC3A1, SLC25A4, ACADVL, NDUFV2, NDUFS4

Biological processes related to hypertrophic cardiomyopathy according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	respiratory chain complex IV assembly	GO:008535	INF	, COX15, SCO2,
2	nerve growth factor receptor signaling pathway	GO:048011	INF	PTPN11, , PRKACA, PRKCA, OBSCN, SOS1
3	fibroblast growth factor receptor signaling pathway	GO:008543	INF	SOS1, PRKCA, PRKACA, , PTPN11, HRAS
4	muscle filament sliding	GO:030049	11.5	MYBPC2, TPM1, TPM2, TPM3, TPM4, TNNC1
5	ventricular cardiac muscle tissue morphogenesis	GO:055010	11.3	TNNC1, TNNI1, TNNI3, TNNT2, GAA, MYH6
6	muscle contraction	GO:006936	11.1	ACTA1, HCN4, TTN, DES, MYH6, MYH7
7	regulation of striated muscle contraction	GO:006942	11.1	MYL3, MYL2, SRI, TNNI1, MYBPH, MYBPC3
8	sarcomere organization	GO:045214	11.0	MYH6, OBSCN, TCAP, TTN, TPM1, ANKRD1
9	regulation of the force of heart contraction	GO:002026	11.0	MYL3, MYH6, GAA, CSRP3, PRKCA, PLN
10	skeletal muscle thin filament assembly	GO:030240	10.9	TCAP, TTN, ACTC1, ACTA1
11	regulation of heart contraction	GO:008016	10.9	MYH6, DES, HCN4, SRI, DMPK, TNNT2
12	regulation of vasodilation	GO:042312	10.8	NPPB, AGTR1, ACE2, ACE
13	regulation of vasoconstriction	GO:019229	10.7	AGTR1, AGT, ACE2, ACE, EDN2, EDN1
14	cardiac myofibril assembly	GO:055003	10.7	MYL2, TCAP, TTN, ACTC1
15	regulation of muscle contraction	GO:006937	10.7	PRKCA, TNNC1, TPM3, TPM1
16	blood vessel remodeling	GO:001974	10.6	CSRP3, AGTR2, AGT, NOS3, IGF1, MEF2C
17	regulation of blood pressure	GO:008217	10.5	MYH6, NPPB, NPPA, POMC, AGTR2, ACE
18	heart development	GO:007507	10.4	PDGFB, PDLIM3, EDN1, NPPB, ADM, COL3A1
19	positive regulation of cardiac muscle hypertrophy	GO:010613	10.4	PRKCA, AGT, EDN1, IGF1
20	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.3	AGTR1, AGT, ACE2, PDGFB, CD36
21	muscle organ development	GO:007517	10.3	GAA, SRI, CAV3, IGF1, MEF2A, MEF2C
22	activation of MAPKK activity	GO:000186	10.3	RAF1, MAP2K2
23	cellular calcium ion homeostasis	GO:006874	10.0	RYR2, CSRP3, PRKCA, TGFB1, PLN, DMPK
24	positive regulation of cellular protein metabolic process	GO:032270	9.7	INS, AGT, AGTR1, TGFB1, ADIPOQ
25	response to estradiol stimulus	GO:032355	9.4	SLC6A4, CALR, ESR1, CYP19A1, NOS3, PDGFB
26	positive regulation of smooth muscle cell proliferation	GO:048661	9.2	PRKCA, EDN1, PDGFB, TNF, IGF1, IL6
27	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	ADIPOQ, AGT, PDGFB, IGF1, IGF2, IL6
28	positive regulation of mitosis	GO:045840	9.0	EDN1, PDGFB, TNF, IGF1, IGF2, INS
29	positive regulation of MAPK cascade	GO:043410	9.0	AGT, PDGFB, HRAS, IGF1, IGFBP3, IGF2
30	platelet degranulation	GO:002576	8.9	PPBP, PDGFB, ACTN1, TTN, TGFB1, KNG1
31	glucose metabolic process	GO:006006	8.8	GAA, ADIPOQ, PRKACA, AGL, TNF, CALM3
32	response to drug	GO:042493	8.4	PDGFB, EDN1, ACTC1, TGFB1, NPPB, SLC6A4
33	response to hypoxia	GO:001666	8.3	ADIPOQ, ADM, RYR2, SLC6A4, NPPB, TGFB1
34	negative regulation of cell proliferation	GO:008285	8.3	TNF, NOS3, AGT, TIMP2, TGFB1, PRKCA
35	platelet activation	GO:030168	8.2	COL1A1, KNG1, COL1A2, COL3A1, PDGFB, ACTN1
36	response to glucocorticoid stimulus	GO:051384	INF	MAP2K1, CCL2, TNF, , AGL, ADM
37	insulin receptor signaling pathway	GO:008286	INF	PTPN11, , PRKAA2, PRKAG2, SOS1, HRAS
38	MAPK cascade	GO:000165	INF	TGFB1, , TNF, HRAS, CCL2, MAP2K1
39	positive regulation of NF-kappaB transcription factor activity	GO:051092	INF	PRKD1, TGFB1, AGT, , TNF, IL6
40	small molecule metabolic process	GO:044281	INF	NDUFS4, NDUFV2, ACADVL, AGL, AGT, PRKAA2
41	Ras protein signal transduction	GO:007265	INF	SOS1, , HRAS, IGF1, MAP2K1, MAP2K2
42	blood coagulation	GO:007596	INF	VWF, CALM3, HRAS, PTPN11, PPBP, NOS3
43	cardiac muscle tissue morphogenesis	GO:055008	INF	TCAP, TTN, ACTC1, ANKRD1,
44	positive regulation of MAP kinase activity	GO:043406	INF	TGFB1, EDN1, , PDGFB, TNF, HTR2A
45	response to peptide hormone stimulus	GO:043434	INF	NPPB, PRKCA, COL1A1, NOS3, GJA1, GNAI1
46	striated muscle contraction	GO:006941	INF	MYH6, TTN, CASQ2, KBTBD10,
47	positive regulation of cell proliferation	GO:008284	INF	HRAS, PDGFB, , EDN1, EDN2, TGFB1
48	epidermal growth factor receptor signaling pathway	GO:007173	INF	SOS1, PRKCA, PRKACA, TGFB1, , PTPN11
49	positive regulation of gene expression	GO:010628	INF	SLC6A4, TGFB1, , GJA1, CALR, MEF2C
50	cardiac muscle contraction	GO:060048	INF	MYL3, GAA, RYR2, TCAP, ACTC1, TNNI3

Molecular functions related to hypertrophic cardiomyopathy according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	INF	TTN, DNAH8, PRKAA2, PRKD1, PRKACA, PRKAG2
2	structural constituent of muscle	GO:008307	11.3	TPM1, TPM2, TPM4, PDLIM3, TTN, TCAP
3	actin binding	GO:003779	11.2	TNNI1, TNNI3, TNNT2, NRAP, ACE, ACTN1
4	titin binding	GO:031432	10.9	OBSCN, TCAP, CALM3, ANKRD1, MYBPC1, MYBPC3
5	platelet-derived growth factor binding	GO:048407	10.5	PDGFB, COL3A1, COL1A2, COL1A1
6	myosin binding	GO:017022	10.3	SLC6A4, ACTC1, ACTA1, MYBPC3
7	troponin T binding	GO:031014	10.3	TNNT1, TNNI3, TNNC1
8	core promoter sequence-specific DNA binding	GO:001046	9.8	ESR2, ESR1, MEF2C, MYOCD
9	eukaryotic cell surface binding	GO:043499	9.7	SELP, ANXA5, PDGFB, TGFB1, ADIPOQ
10	insulin-like growth factor receptor binding	GO:005159	9.4	IGF1, IGF2, INS, REN
11	receptor binding	GO:005102	9.4	POMC, NPPA, NPPB, KNG1, ADM, ADIPOQ
12	hormone activity	GO:005179	9.3	POMC, NPPA, NPPB, ADM, ADIPOQ, TTR
13	enzyme binding	GO:019899	9.2	SLC25A4, SLPI, PRKCA, TGFB1, TTN, ESR2
14	protein heterodimerization activity	GO:046982	INF	MYH7, MYH6, SLC3A1, TGFB1, AGTR1, PDGFB
15	protein binding	GO:005515	INF	COL1A1, THBD, TGFB1, TCAP, DES, PRKAA2
16	calcium ion binding	GO:005509	INF	ACTN1, TTN, THBD, PVALB, RYR2, MYL2