MCID: HYP061
MIFTS: 59

Hypertrophic Cardiomyopathy malady

Genetic diseases, Rare diseases, Cardiovascular diseases categories

Summaries for Hypertrophic Cardiomyopathy

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Genetics Home Reference:21 Familial hypertrophic cardiomyopathy is a heart condition characterized by thickening (hypertrophy) of the heart (cardiac) muscle. Thickening usually occurs in the interventricular septum, which is the muscular wall that separates the lower left chamber of the heart (the left ventricle) from the lower right chamber (the right ventricle). In some people, thickening of the interventricular septum impedes the flow of oxygen-rich blood from the heart, which may lead to an abnormal heart sound during a heartbeat (heart murmur) and other signs and symptoms of the condition. Other affected individuals do not have physical obstruction of blood flow, but the pumping of blood is less efficient, which can also lead to symptoms of the condition. Cardiac hypertrophy often begins in adolescence or young adulthood, although it can develop at any time throughout life.

MalaCards based summary: Hypertrophic Cardiomyopathy, also known as familial hypertrophic cardiomyopathy, is related to congestive heart failure and myocarditis. An important gene associated with Hypertrophic Cardiomyopathy is MT-TI (mitochondrially encoded tRNA isoleucine), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Tight junction. The compounds polyacrylamide and bts have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are normal and growth/size/body.

Disease Ontology:9 An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.

Wikipedia:63 Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in... more...

GeneReviews summary for hyper-card

Aliases & Classifications for Hypertrophic Cardiomyopathy

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Hypertrophic Cardiomyopathy, Aliases & Descriptions:

Name: Hypertrophic Cardiomyopathy 9 19 11 60
Familial Hypertrophic Cardiomyopathy 9 41 21 11
Idiopathic Hypertrophic Subaortic Stenosis 41 21
Cardiomyopathy Familial Hypertrophic 41 20
Hereditary Ventricular Hypertrophy 41 21
Asymmetric Septal Hypertrophy 41 60
Rare Familial Disorder with Hypertrophic Obstructive Cardiomyopathy 41
 
Rare Familial Disorder with Hypertrophic Subaortic Stenosis 41
Rare Familial Disorder with Hypertrophic Cardiomyopathy 41
Hypertrophic Obstructive Cardiomyopathy 9
Cardiomyopathy Hypertrophic Obstructive 43
Cardiomyopathy, Hypertrophic, Familial 60
Familial Asymmetric Septal Hypertrophy 21
Hcm 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:11984
ICD9CM27 425.1
ICD1025 I42.1

Related Diseases for Hypertrophic Cardiomyopathy

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Diseases in the Hypertrophic Cardiomyopathy family:

Cardiomyopathy, Familial Hypertrophic, 20 Cardiomyopathy, Familial Hypertrophic, 2
Cardiomyopathy, Familial Hypertrophic, 9 Cardiomyopathy, Familial Hypertrophic, 13
Cardiomyopathy, Familial Hypertrophic, 8 Cardiomyopathy, Familial Hypertrophic, 16
Cardiomyopathy, Familial Hypertrophic, 18 Cardiomyopathy, Familial Hypertrophic, 21
Cardiomyopathy, Familial Hypertrophic, 15 Cardiomyopathy, Familial Hypertrophic, 12
Cardiomyopathy, Familial Hypertrophic, 4 Cardiomyopathy, Familial Hypertrophic, 10
Cardiomyopathy, Familial Hypertrophic, 14 Cardiomyopathy, Familial Hypertrophic, 1
Cardiomyopathy, Familial Hypertrophic, 11 Cardiomyopathy, Familial Hypertrophic, 3
Cardiomyopathy, Familial Hypertrophic, 19 Cardiomyopathy, Familial Hypertrophic, 7
Cardiomyopathy, Familial Hypertrophic 6 Cardiomyopathy, Familial Hypertrophic 17
Cav3-Related Hypertrophic Cardiomyopathy Myh7-Related Familial Hypertrophic Cardiomyopathy
Tnnt2-Related Familial Hypertrophic Cardiomyopathy Tpm1-Related Familial Hypertrophic Cardiomyopathy
Mybpc3-Related Familial Hypertrophic Cardiomyopathy Tnni3-Related Familial Hypertrophic Cardiomyopathy
Myl3-Related Familial Hypertrophic Cardiomyopathy Myl2-Related Familial Hypertrophic Cardiomyopathy
Ttn-Related Familial Hypertrophic Cardiomyopathy Actc1-Related Familial Hypertrophic Cardiomyopathy
Myh6-Related Familial Hypertrophic Cardiomyopathy Tcap-Related Familial Hypertrophic Cardiomyopathy
Csrp3-Related Familial Hypertrophic Cardiomyopathy Tnnc1-Related Familial Hypertrophic Cardiomyopathy
Actn2-Related Familial Hypertrophic Cardiomyopathy Myoz2-Related Familial Hypertrophic Cardiomyopathy
Nexn-Related Familial Hypertrophic Cardiomyopathy Pln-Related Familial Hypertrophic Cardiomyopathy

Diseases related to Hypertrophic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 364)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.1TNNI3, TNNT2
2myocarditis31.1MYH6, TNNT2, TNNI3
3diastolic heart failure30.9TTN
4myopathy30.8TCAP, MYH6, MYH7, TTN, TNNI3, TNNT2
5restrictive cardiomyopathy30.7TNNT2, TNNI3
6acute myocardial infarction30.5TNNI3, MYH7, TNNT2, MYL3
7duchenne muscular dystrophy30.2TCAP, TTN, TNNI3, TNNT2
8congenital heart disease30.2MYH7, MYBPC3, TTN, TNNI3, TNNT2, MYH6
9dilated cardiomyopathy29.7TNNT2, SLC25A4, CSRP3, PLN, ACTC1, TCAP
10noonan syndrome 129.2TNNI3, TTN, MYBPC3, MYH7, MYL2, MYH6
11left ventricular outflow tract obstruction10.8
12hypertensive heart disease10.6
13atrial fibrillation10.6
14aneurysm10.6
15leopard syndrome10.5
16cardiomyopathy, familial hypertrophic 1710.5
17fabry disease10.5
18myocardial infarction10.5
19cardiomyopathy, familial hypertrophic, 2010.5
20cardiomyopathy, familial hypertrophic, 910.5
21cardiomyopathy, familial hypertrophic, 1810.5
22cardiomyopathy, familial hypertrophic, 1210.5
23cardiomyopathy, familial hypertrophic, 710.5
24acquired von willebrand syndrome10.5
25costello syndrome10.5
26left ventricular noncompaction10.5
27familial restrictive cardiomyopathy10.4MYH7, TNNI3
28nemaline myopathy10.4
29wolff-parkinson-white syndrome10.4
30danon disease10.4
31glycogen storage disease10.4
32long qt syndrome10.4
33progressive sensorineural hearing loss - hypertrophic cardiomyopathy10.4
34fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex i deficiency10.4
35intermediate coronary syndrome10.4TNNT2, TNNI3
36chronic progressive external ophthalmoplegia10.4SLC25A4
37distal arthrogryposis10.4TPM1
38sengers syndrome10.4
39cardiomyopathy, familial hypertrophic, 110.4
40friedreich ataxia10.4
41distal muscular dystrophy10.4TTN, MYH7
42subacute bacterial endocarditis10.4
43dumping syndrome10.4
44spinocerebellar ataxia10.3TNNT2, MYH7
45angiodysplasia10.3
46muscle hypertrophy10.3
47obesity10.3
48cardiofaciocutaneous syndrome10.3
49endotheliitis10.3
50hypertrophic cardiomyopathy and renal tubular disease due to mitochondrial dna mutation10.3

Graphical network of the top 20 diseases related to Hypertrophic Cardiomyopathy:



Diseases related to hypertrophic cardiomyopathy

Symptoms for Hypertrophic Cardiomyopathy

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Drugs & Therapeutics for Hypertrophic Cardiomyopathy

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Drug clinical trials:

Search ClinicalTrials for Hypertrophic Cardiomyopathy

Search NIH Clinical Center for Hypertrophic Cardiomyopathy

Genetic Tests for Hypertrophic Cardiomyopathy

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Genetic tests related to Hypertrophic Cardiomyopathy:

id Genetic test Affiliating Genes
1 Familial Hypertrophic Cardiomyopathy20 TTN

Anatomical Context for Hypertrophic Cardiomyopathy

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MalaCards organs/tissues related to Hypertrophic Cardiomyopathy:

31
Heart, Testes, Brain, Endothelial, Cardiac myocytes, Skeletal muscle, Liver, Smooth muscle, Adipocyte, Kidney, Skin, Monocytes

Animal Models for Hypertrophic Cardiomyopathy or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Cardiomyopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8TNNT2, TTN, TPM1, MYL2, ACTC1, SLC25A4
2MP:00053788.5TNNT2, TTN, TPM1, MYBPC3, MYL2, MYO6
3MP:00053868.3TTN, MYBPC3, MYO6, MYH6, TCAP, PLN
4MP:00107687.5TPM1, TTN, TNNI3, TNNT2, MYL2, MYO6
5MP:00053767.3TNNT2, TTN, MYBPC3, MYL2, MYO6, MYH6
6MP:00053697.2SLC25A4, TNNT2, TNNI3, TTN, MYBPC3, MYL2
7MP:00053856.9MYBPC3, TPM1, TTN, TNNI3, TNNT2, MYL2

Publications for Hypertrophic Cardiomyopathy

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Articles related to Hypertrophic Cardiomyopathy:

(show top 50)    (show all 1392)
idTitleAuthorsYear
1
Comparison of the new risk prediction model (HCM Risk-SCD) and classic risk factors for sudden death in patients with hypertrophic cardiomyopathy and defibrillator. (25855675)
2015
2
Abnormal T2-STIR Magnetic Resonance in Hypertrophic Cardiomyopathy: A Marker of Advanced Disease and Electrical Myocardial Instability. (25356653)
2014
3
A case of an infant with compound heterozygous mutations for hypertrophic cardiomyopathy producing a phenotype of left ventricular noncompaction. (25262865)
2014
4
Risk of death in long-term follow-up of patients with apical hypertrophic cardiomyopathy. (23540548)
2013
5
Determining pathogenicity of genetic variants in hypertrophic cardiomyopathy: importance of periodic reassessment. (24113344)
2013
6
Re: Assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: First-pass myocardial perfusion cardiovascular magnetic resonance imaging at 1.5A T. (24290778)
2013
7
Relation between left ventricular outflow tract obstruction and left ventricular shape in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance imaging study. (23906680)
2013
8
T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy. (23549607)
2013
9
Mutations in the cardiac troponin T gene show various prognoses in Japanese patients with hypertrophic cardiomyopathy. (23494605)
2013
10
Fast diastolic swinging motion of the mitral valve as a clinical marker of familial hypertrophic cardiomyopathy in genetically affected young children without left ventricular hypertrophy: a new role for noninvasive imaging? (23557229)
2013
11
A unique case of a 7-year-old with noonan's syndrome, hypertrophic cardiomyopathy, biventricular outflow tract obstruction, and a right ventricular aneurysm. (23747783)
2013
12
Epicardial ablation of monomorphic ventricular tachycardia in a case of hypertrophic cardiomyopathy with apical aneurysm. (22764201)
2013
13
Pregnancy outcome in a case of non-obstructive hypertrophic cardiomyopathy. (23982559)
2013
14
Familial hypertrophic cardiomyopathy: is the Frank-Starling law kaput? (23704214)
2013
15
Mid-term outcomes of alcohol septal ablation for obstructive hypertrophic cardiomyopathy in patients with sigmoid versus neutral ventricular septum. (23220977)
2012
16
Outcome and complications after implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy: systematic review and meta-analysis. (22821634)
2012
17
Recurrent unilateral pleural effusion in a hypertrophic cardiomyopathy patient secondary to atrial arrhythmias and the role of radiofrequency ablation. (22622140)
2012
18
Apical hypertrophic cardiomyopathy with apical aneurysm in an African-American male. (22499000)
2012
19
A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties. (21256114)
2011
20
Cardiac MRI in a patient with coincident left ventricular non-compaction and hypertrophic cardiomyopathy. (23074372)
2011
21
The role of alcohol septal ablation in the treatment of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. (22093511)
2011
22
Mutations in the beta-myosin heavy chain gene in southern Chinese families with hypertrophic cardiomyopathy. (20819418)
2010
23
Cardiac tamponade or normal respiratory variation? An illustrative case of septal ablation for obstructive hypertrophic cardiomyopathy. (20549684)
2010
24
Hypertrophic cardiomyopathy: from genetics to treatment. (20503496)
2010
25
Hypertrophic cardiomyopathy due to beta-myosin heavy chain mutation with extreme phenotypic variability within a family. (18374998)
2009
26
The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study. (19074594)
2009
27
A novel mutation of the beta myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy. (19645038)
2009
28
Hypertrophic cardiomyopathy. A study of the troponin-T gene in 127 Spanish families. (20038417)
2009
29
ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy. (18165925)
2008
30
Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy. (18195461)
2007
31
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. (17416600)
2007
32
Clinical significance of N-terminal-probrain natriuretic peptide in hypertrophic cardiomyopathy. (17879024)
2007
33
Hypertrophic cardiomyopathy in Noonan Syndrome closely mimics familial hypertrophic cardiomyopathy due to sarcomeric mutations. (16267621)
2006
34
Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy. (16214409)
2006
35
Hypertrophic cardiomyopathy in a Portuguese population: mutations in the myosin-binding protein C gene. (16566405)
2005
36
Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy. (12860912)
2003
37
Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins. (12006676)
2002
38
Increased plasma brain natriuretic peptide level as a guide for silent myocardial ischemia in patients with non-obstructive hypertrophic cardiomyopathy. (12020494)
2002
39
Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility. (11853553)
2002
40
Coexistence of hypertrophic cardiomyopathy and fibromuscular dysplasia of the superior mesenteric artery. (11336027)
2001
41
Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy. (10966831)
2000
42
Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy. (10764406)
2000
43
Phenotypic variation of familial hypertrophic cardiomyopathy caused by the Phe(110)-->Ile mutation in cardiac troponin T. (10965086)
2000
44
Familial hypertrophic cardiomyopathy: a paradigm of the cardiac hypertrophic response to injury. (9800880)
1998
45
Genetic heterogeneity for familial hypertrophic cardiomyopathy in Chinese: analysis of six Chinese kindreds. (10374350)
1998
46
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. (9241277)
1997
47
Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy. (8523464)
1995
48
The electrocardiogram is a more sensitive indicator than echocardiography of hypertrophic cardiomyopathy in families with a mutation in the MYH7 gene. (7848420)
1994
49
Multiple respiratory chain abnormalities associated with hypertrophic cardiomyopathy and 3-methylglutaconic aciduria. (7691603)
1993
50
HLA linkage vs association in hypertrophic cardiomyopathy. Evidence for the absence of an association in a heterogeneous Caucasian population. (7200000)
1982

Variations for Hypertrophic Cardiomyopathy

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Clinvar genetic disease variations for Hypertrophic Cardiomyopathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1MT-TIm.4295A> Gsingle nucleotide variantPathogenicrs121434467GRCh37Chr MT, 4295: 4295

Expression for genes affiliated with Hypertrophic Cardiomyopathy

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Search GEO for disease gene expression data for Hypertrophic Cardiomyopathy.

Pathways for genes affiliated with Hypertrophic Cardiomyopathy

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Pathways related to Hypertrophic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MYL2, MYH7
29.8MYH7, MYL2, MYH6
3
Show member pathways
9.6MYH6, MYO6, MYH7
4
Show member pathways
9.6MYL3, MYL2, MYH6, MYH7
5
Show member pathways
Calcium Regulation in the Cardiac Cell36
9.5MYL2, ACTC1, PLN
6
Show member pathways
9.4MYL2, MYL3, TNNI3, PLN
79.3SLC25A4, PLN, TNNC1
89.3ACTC1, TNNI3, MYL2, TNNT2, MYH6
9
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.3MYL2, MYH7, MYL3, ACTC1, MYH6
10
Show member pathways
9.2PLN, TNNT2, TNNC1, TNNI3
119.2TPM1, TNNI3, ACTC1, MYO6, TNNT2
12
Show member pathways
9.2MYH6, MYL2, MYL3, MYH7, MYO6
13
Show member pathways
9.2MYO6, MYL3, MYL2, MYH6, MYH7
14
Show member pathways
9.2MYO6, MYH7, MYL3, MYH6, MYL2
15
Show member pathways
9.2MYO6, MYH7, MYH6, MYL3, MYL2
16
Show member pathways
9.2MYO6, MYH7, MYL3, MYL2, MYH6
17
Show member pathways
9.2MYO6, MYL2, MYL3, MYH7, MYH6
18
Show member pathways
9.2MYH6, MYO6, MYL3, MYH7, MYL2
198.3TNNI3, TPM1, MYH7, MYL3, MYL2, MYH6
207.9TNNT2, TNNC1, TNNI3, TPM1, MYH7, PLN
21
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
7.5TNNC1, TNNI3, TTN, TPM1, MYBPC3, MYH7
22
Show member pathways
7.3ACTC1, MYH6, MYL2, MYL3, MYBPC3, TPM1

Compounds for genes affiliated with Hypertrophic Cardiomyopathy

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Compounds related to Hypertrophic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 11)
idCompoundScoreTop Affiliating Genes
1polyacrylamide439.9MYH6, MYH7, TTN
2bts599.8MYL2, MYL3, MYH7, MYH6
3(r)-(+)-blebbistatin599.8MYH6, MYL2, MYL3, MYH7
4ryanodine43 28 5911.8TTN, MYH7, MYH6
5(s)-(-)-blebbistatin599.7MYH7, MYH6, MYL2, MYL3
6(+-)-blebbistatin599.7MYH6, MYL2, MYL3, MYH7
7n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide43 1210.6TNNI3, TNNC1
8actomyosin439.6TNNC1, TTN, MYH7, ACTC1
9creatinine439.0TNNT2, TNNI3, TTN, MYH7, MYL3, ACTC1
10atp43 289.9SLC25A4, MYH6, MYO6, MYH7, MYBPC3, TTN
11calcium43 49 24 129.9SLC25A4, TNNT2, TNNC1, TNNI3, TTN, TPM1

GO Terms for genes affiliated with Hypertrophic Cardiomyopathy

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Cellular components related to Hypertrophic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1A bandGO:003167210.0MYBPC3, MYL3, MYL2
2striated muscle thin filamentGO:000586510.0TTN, TNNT2
3myofibrilGO:003001610.0MYH6, MYL2
4muscle myosin complexGO:00058599.9MYH7, MYL3, MYH6
5troponin complexGO:00058619.9TNNI3, TNNC1, TNNT2
6myosin filamentGO:00329829.9MYH7, MYH6, MYBPC2
7myosin complexGO:00164599.9MYH6, MYL2, MYH7
8stress fiberGO:00017259.8TPM1, MYH7, MYH6
9filamentous actinGO:00319419.6MYO6, TPM1
10I bandGO:00316749.5TTN, MYL3, TCAP, ACTC1
11Z discGO:00300189.3TTN, MYH7, MYH6, TCAP, CSRP3
12sarcomereGO:00300178.8ACTC1, TNNT2, TNNI3, TPM1, MYBPC3, MYH7
13cytosolGO:00058297.2TPM1, TTN, TNNI3, TNNC1, TNNT2, MYBPC3

Biological processes related to Hypertrophic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of striated muscle contractionGO:000694210.1MYL2, MYL3, MYBPC3
2striated muscle contractionGO:000694110.1MYH6, MYH7, TTN
3heart contractionGO:006004710.1ACTC1, MYL2, TNNI3
4regulation of heart rateGO:000202710.0MYH6, MYH7, MYBPC3
5positive regulation of ATPase activityGO:003278110.0MYL3, MYBPC3, TPM1, TNNT2
6regulation of muscle contractionGO:00069379.9TPM1, TNNC1, TNNT2
7negative regulation of ATPase activityGO:00327809.9PLN, TNNI3, TNNT2
8atrial cardiac muscle tissue morphogenesisGO:00550099.9MYH6, TNNT2
9skeletal muscle myosin thick filament assemblyGO:00302419.9TCAP, TTN
10detection of muscle stretchGO:00359959.9TTN, TCAP, CSRP3
11cardiac muscle hypertrophyGO:00033009.9TTN, TCAP, CSRP3
12skeletal muscle thin filament assemblyGO:00302409.9TTN, TCAP, ACTC1
13sarcomerogenesisGO:00487699.8TCAP, TTN
14muscle contractionGO:00069369.8TTN, TPM1, MYH7, MYH6
15regulation of ATPase activityGO:00434629.8TNNC1, MYH6
16in utero embryonic developmentGO:00017019.8MYH6, TPM1, TTN
17cardiac muscle fiber developmentGO:00487399.8TTN, MYH6, TCAP
18cardiac muscle tissue morphogenesisGO:00550089.8TTN, TCAP, ACTC1
19ATP catabolic processGO:00062009.7TNNT2, MYH7, MYH6, ACTC1
20adult heart developmentGO:00075129.7TTN, MYH7, MYH6, TCAP
21cardiac muscle tissue developmentGO:00487389.7PLN, CSRP3, NDUFV2
22regulation of heart contractionGO:00080169.7PLN, MYH6, TPM1, TNNT2
23actin filament-based movementGO:00300489.5ACTC1, MYO6
24regulation of the force of heart contractionGO:00020269.5MYH7, MYL3, MYH6, PLN, CSRP3
25cardiac myofibril assemblyGO:00550039.4TTN, MYL2, TCAP, ACTC1, CSRP3
26sarcomere organizationGO:00452149.3TNNT2, TTN, TPM1, MYBPC3, MYH6, TCAP
27ventricular cardiac muscle tissue morphogenesisGO:00550108.8TNNT2, MYH6, MYL2, MYL3, MYH7, MYBPC3
28cardiac muscle contractionGO:00600488.3MYL3, MYBPC3, TPM1, TTN, TNNI3, TNNC1
29muscle filament slidingGO:00300497.5ACTC1, TCAP, MYBPC2, MYH6, MYL2, MYL3

Molecular functions related to Hypertrophic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:003017210.4TNNI3, TNNT2
2telethonin bindingGO:003143310.3CSRP3, TTN
3myosin heavy chain bindingGO:003203610.3MYBPC3, MYL2
4actinin bindingGO:004280510.3CSRP3, TTN
5troponin T bindingGO:003101410.2TNNI3, TNNC1
6actin-dependent ATPase activityGO:003089810.1MYH6, MYH7
7troponin I bindingGO:003101310.1TNNT2, TNNC1
8microfilament motor activityGO:000014610.0MYH6, MYH7
9actin monomer bindingGO:00037859.9MYL3, MYL2
10ATPase activityGO:00168879.9TNNT2, MYH7, MYH6, ACTC1
11titin bindingGO:00314329.8MYBPC3, TCAP
12myosin bindingGO:00170229.7ACTC1, MYBPC3
13calmodulin bindingGO:00055169.7TTN, MYH7, MYO6, MYH6
14actin filament bindingGO:00510159.7MYO6, TTN, TNNC1
15calcium ion bindingGO:00055099.3TNNC1, TTN, MYL3, MYL2, CALR3
16actin bindingGO:00037798.9TNNT2, TNNI3, TPM1, MYBPC3, MYH7, MYO6
17structural constituent of muscleGO:00083078.7CSRP3, TTN, TPM1, MYBPC3, MYL3, MYL2
18protein bindingGO:00055157.1TNNC1, TNNI3, TTN, MYH7, MYL2, MYO6

Products for genes affiliated with Hypertrophic Cardiomyopathy

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Sources for Hypertrophic Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
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