MCID: HYP009
MIFTS: 42

Hypertrophic Pyloric Stenosis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 10 12
Pyloric Stenosis, Hypertrophic 36 65
 
Congenital or Infantile Stricture of Pylorus 10
Congenital Hypertrophic Pyloric Stenosis 10

Classifications:



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Disease Ontology10 DOID:12638
ICD1027 Q40.0
ICD9CM29 750.5
SNOMED-CT59 48644003
MeSH36 D046248
NCIt42 C98952
UMLS65 C0700639

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:10 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and acquired gastric outlet stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways are TRP channels and Cardiomyocyte Differentiation through BMP Receptors. Affiliated tissues include lung, prostate and liver, and related mouse phenotypes are respiratory system and behavior/neurological.

Related Diseases for Hypertrophic Pyloric Stenosis

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Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric StenosisCompletedNCT00195949Phase 3
2The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in ChildhoodNot yet recruitingNCT01159509

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis


Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

33
Lung, Prostate, Liver, Brain, T cells, Breast, Bone

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7HMOX2, IGF1, NKX2-5, NOS1, RET
2MP:00053867.9GDNF, HMOX2, MBNL1, NOS1, RET, TRPC5
3MP:00053847.3GDNF, IGF1, NKX2-5, NOS1, RET, TRPC5
4MP:00053697.3GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
5MP:00053857.3GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
6MP:00036316.2GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1. (25972997)
2015
2
How much related to skin wrinkles between facial and body site? Age-related changes in skin wrinkle on the knee assessed by skin bioengineering techniques. (25801732)
2015
3
Subclinical nutritional rickets among adolescents in Kaghan Valley. (25233972)
2014
4
Cutaneous necrotizing vasculitis as a manifestation of familial Mediterranean fever. (25109905)
2014
5
Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy. (25067791)
2014
6
Herpes simplex encephalitis presenting with normal CSF analysis. (24169394)
2013
7
Lung transplantation for cystic fibrosis and bronchiectasis. (23821505)
2013
8
Surgery for macular holes associated with unusual concomitant pathologies. (24082671)
2013
9
Intensified surveillance and insecticide-based control of the Chagas disease vector Triatoma infestans in the Argentinean Chaco. (23593525)
2013
10
Acute right ventricular failure caused by concomitant coronary and pulmonary embolism: successful treatment with endovascular coronary and pulmonary thrombectomy. (24222822)
2013
11
Concomitant BCR-ABL1 translocation and JAK2(V617F) mutation in three patients with myeloproliferative neoplasms. (22847163)
2012
12
Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis. (22778396)
2012
13
Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL- 1/4.1B). (21131357)
2011
14
The nucleotide-binding domain 2 of the human transporter protein MRP6. (21748403)
2011
15
Mixed-cell granulomatous panniculitis on the cheek due to injection of solution containing phosphatidylcholine and deoxycholate. (20979342)
2010
16
Improved cardiac function after sirolimus-eluting stent placement in diabetic patients by pioglitazone: combination therapy with statin. (19477383)
2009
17
Changes of blood count, lymphocyte subpopulations and immunoglobulin levels in nephroblastoma long term survivors. (19152239)
2009
18
Calcinosis cutis associated with amyopathic dermatomyositis: response to intravenous immunoglobulin. (19467386)
2009
19
Relationship between inflammatory markers and clinical patterns of atrial fibrillation in patients with congestive heart failure. (18690564)
2008
20
Acid sphingomyelinase-deficient Niemann-Pick disease: novel findings in a Greek child. (17876723)
2007
21
Protein-losing enteropathy in systemic lupus erythematosus: analysis of the clinical features of fifteen patients. (18176138)
2007
22
A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis. (17517891)
2007
23
Iron stores and HFE genotypes are not related to increased risk of ischemic stroke. A prospective nested case-referent study. (17878720)
2007
24
The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo. (17342332)
2007
25
Expression and significance of hTERT, c-fos and c-jun in ameloblastoma]. (17348214)
2006
26
Geometric differences of the mitral valve tenting between anterior and inferior myocardial infarction with significant ischemic mitral regurgitation: quantitation by novel software system with transthoracic real-time three-dimensional echocardiography. (16423672)
2006
27
Clinical impact of 18F-FDG-PET in the suspicion of recurrent colorectal cancer based on asymptomatically elevated serum level of carcinoembryonic antigen (CEA) in Taiwan. (16795969)
2006
28
Thrombophilias and recurrent pregnancy loss. (16418978)
2006
29
Safety and potential of drug interactions of caspofungin and voriconazole in multimorbid patients. (16192747)
2005
30
Differentially expressed genes in the lens of mimecan-null mice. (15215744)
2004
31
Mechanisms of antigen receptor evolution. (15522620)
2004
32
Cytotoxicity and antimicrobial susceptibility of Clostridium difficile isolated from hospitalized children with acute diarrhea. (16701515)
2004
33
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (12687004)
2003
34
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases. (14528050)
2003
35
Wound healing: the role of growth factors. (14668934)
2003
36
Extraskeletal myxoid chondrosarcoma of the knee. (10883455)
2000
37
Multinodular fatty change in the liver in patients with chronic hepatic porphyria. (10475932)
1999
38
Expression of p16 and CDK4 in oral premalignant lesions and oral squamous cell carcinomas: a semi-quantitative immunohistochemical study. (10235368)
1999
39
FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO. (9765293)
1998
40
Modulation of growth factors by growth hormone in children with chronic renal failure. The Southwest Pediatric Nephrology Study Group. (9186890)
1997
41
Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus. (8809087)
1996
42
Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C. (7816824)
1995
43
Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. (8196175)
1994
44
Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. (8314854)
1993
45
Multiple symmetrical lipomatosis. (1521476)
1992
46
High evolutionary conservation of the secondary structure and of certain nucleotide sequences of U5 RNA. (6200827)
1983
47
The Arthus reaction in rats, a possible test for anti-inflammatory and antiheumatic drugs. (157676)
1979
48
Reconstruction of microtia using the Silastic frame. (359220)
1978
49
PARATYPHOID fever and cream cakes. (13094092)
1953
50

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1manganese ion transportGO:000682810.2TRPC5, TRPC6
2regulation of cardiac muscle contractionGO:005511710.2NKX2-5, NOS1
3response to nutrient levelsGO:003166710.1IGF1, NOS1
4regulation of cardiac conductionGO:19037799.9NKX2-5, NOS1
5response to heatGO:00094089.3IGF1, NOS1
6axon guidanceGO:00074119.2GDNF, TRPC5, TRPC6
7positive regulation of transcription, DNA-templatedGO:00458939.2IGF1, NKX2-5, NOS1, RET
8positive regulation of cell proliferationGO:00082849.1GDNF, IGF1, NKX2-5
9negative regulation of apoptotic processGO:00430668.9GDNF, IGF1, NKX2-5, NOS1
10positive regulation of transcription from RNA polymerase II promoterGO:00459448.6GDNF, IGF1, NKX2-5, NOS1

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inositol 1,4,5 trisphosphate bindingGO:00706799.7TRPC5, TRPC6

Sources for Hypertrophic Pyloric Stenosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet