MCID: HYP009
MIFTS: 41

Hypertrophic Pyloric Stenosis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 11 13
Pyloric Stenosis, Hypertrophic 39 68
 
Congenital or Infantile Stricture of Pylorus 11
Congenital Hypertrophic Pyloric Stenosis 11

Classifications:



External Ids:

Disease Ontology11 DOID:12638
ICD1030 Q40.0
ICD9CM32 750.5
SNOMED-CT62 48644003
MeSH39 D046248
NCIt45 C98952

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:11 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and acquired gastric outlet stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways are TRP channels and Muscular Dystrophies and Dystrophin-Glycoprotein Complex. Affiliated tissues include pancreas, smooth muscle and heart, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Hypertrophic Pyloric Stenosis

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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1pyloric stenosis12.0
2acquired gastric outlet stenosis11.7
3esophagitis10.3
4esophageal atresia10.2
5pylorospasm10.2
6neuronitis10.1
7tracheoesophageal fistula10.1
8liver leiomyoma10.1NOS1, RET
9proliferating trichilemmal cyst10.1DMD, NOS1
10pertussis10.0
11gilbert syndrome10.0
12thrombocytopenia, x-linked10.0DMD, NOS1
13lung large cell carcinoma10.0NTRK3, SST
14heart disease10.0
15gastroenteritis10.0
16adenomyoma10.0
17congenital diaphragmatic hernia10.0
18eosinophilic gastroenteritis10.0
19pancreatitis10.0
20duodenitis10.0
21achalasia10.0
22adenosquamous cell lung carcinoma9.9NTRK3, SST
23muscle hypertrophy9.8
24sudden infant death syndrome9.8
25cystic fibrosis9.8
26osteoglophonic dysplasia9.8
27citrullinemia9.8
28phenylketonuria9.8
29gastroesophageal reflux9.8
30insulin-like growth factor i9.8
31androgen insensitivity9.8
32jejunal atresia9.8
33pulmonary hypertension9.8
34congenital hypothyroidism9.8
35hydronephrosis9.8
36nephrocalcinosis9.8
37down syndrome9.8
38hypothyroidism9.8
39ventricular septal defect9.8
40intestinal perforation9.8
41dyspepsia9.8
42epidermolysis bullosa9.8
43cutis laxa9.8
44gastric dilatation9.8
45gastritis9.8
46eosinophilic gastritis9.8
47congenital mesoblastic nephroma9.8
48conjunctivitis9.8
49polyhydramnios9.8
50gastroduodenitis9.8

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms & Phenotypes for Hypertrophic Pyloric Stenosis

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

41 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1DMD, HMOX2, NOS1, RET, SST
2MP:00053698.6DMD, HMOX2, MBNL1, NKX2-5, NOS1, RET
3MP:00028738.4DMD, NKX2-5, NOS1, NTRK3, RET, SST
4MP:00030128.1DMD, NKX2-5, NOS1, NTRK3, RET, SST
5MP:00053857.9DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTRK3
6MP:00053767.8DMD, HMOX2, NKX2-5, NOS1, NTF4, RET
7MP:00053887.7DMD, HMOX2, NKX2-5, NOS1, NTRK3, RET
8MP:00053787.6DMD, MBNL1, NKX2-5, NOS1, NTF4, NTRK3
9MP:00107687.0DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4
10MP:00053866.7DMD, HMOX2, MBNL1, NOS1, NTF4, NTRK3
11MP:00036316.3DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4

Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Drugs for Hypertrophic Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Central Nervous System Depressants12806
2Anesthetics9001

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric StenosisCompletedNCT00195949Phase 3
2The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in ChildhoodUnknown statusNCT01159509
3Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal AnesthesiaNot yet recruitingNCT02879292

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis


Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

36
Pancreas, Smooth muscle, Heart, Testes, Endothelial, Cervix, Liver

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. (27292596)
2016
2
Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. (27669400)
2016
3
Adult idiopathic hypertrophic pyloric stenosis. (27362602)
2016
4
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. (26837724)
2016
5
Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. (27599310)
2016
6
The cervix sign and other sonographic signs of hypertrophic pyloric stenosis. (27315074)
2016
7
Treating idiopathic hypertrophic pyloric stenosis with sequential therapy: A clinical study. (27439633)
2016
8
Successful combination of endoscopic pyloromyotomy and balloon dilatation for hypertrophic pyloric stenosis in an older child: A novel procedure. (27915443)
2016
9
Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease. (27528563)
2016
10
Ultrasound assessment of the gastric contents for the guidance of the anaesthetic strategy in infants with hypertrophic pyloric stenosis: a prospective cohort study. (27106968)
2016
11
Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. (27642452)
2016
12
Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. (27215474)
2016
13
Asymmetric Hypertrophic Pyloric Stenosis with Concurrent Pancreatic Rest Presenting as Gastric Outlet Obstruction. (27179550)
2016
14
Health disparities in infants with hypertrophic pyloric stenosis. (27586849)
2016
15
A randomized trial to assess advancement of enteral feedings following surgery for hypertrophic pyloric stenosis. (27829521)
2016
16
Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. (26944185)
2016
17
Is there any correlation between radiologic findings and eradication of symptoms after pyloromyotomy in hypertrophic pyloric stenosis? (27251656)
2016
18
Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. (27506212)
2016
19
Optimizing fluid resuscitation in hypertrophic pyloric stenosis. (26876090)
2016
20
Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. (27655365)
2016
21
A novel missense mutation in the transcription factor FOXF1 co-segregating with infantile hypertrophic pyloric stenosis in the extended pedigree linked to IHPS5 on chromosome 16q24. (27855150)
2016
22
Recent changes in the features of hypertrophic pyloric stenosis. (26615824)
2016
23
Ultrasound-guided paravertebral block for pyloromyotomy in 3 neonates with congenital hypertrophic pyloric stenosis. (26123148)
2015
24
Infantile hypertrophic pyloric stenosis at a tertiary care hospital in Tanzania: a surgical experience with 102 patients over a 5-year period. (26581339)
2015
25
Incidence and Concurrent Laparoscopic Repair of Hypertrophic Pyloric Stenosis and Patent Processus Vaginalis. (25836622)
2015
26
Spontaneous Intestinal Perforation and Infantile Hypertrophic Pyloric Stenosis in a Preterm Neonate: A Linked Etiopathogenesis? (26055488)
2015
27
Maternal Factors in the Origin of Infantile Hypertrophic Pyloric Stenosis - a Population-based Case-control Study. (26394719)
2015
28
Brain oxygenation during laparoscopic correction of hypertrophic pyloric stenosis. (25768674)
2015
29
Adult idiopathic hypertrophic pyloric stenosis. (26154756)
2015
30
The use of ultrasonography in infantile hypertrophic pyloric stenosis: does the patient's age and weight affect pyloric size and pyloric ratio? (25745654)
2015
31
Birth outcomes of male and female patients with infantile hypertrophic pyloric stenosis - a population-based case-control study. (26135791)
2015
32
Association of prematurity with the development of infantile hypertrophic pyloric stenosis. (25950452)
2015
33
Infantile Hypertrophic Pyloric Stenosis in Postoperative Esophageal Atresia with Tracheoesophageal Fistula. (26290814)
2015
34
Is There a Relation Between Pyloric Muscle Thickness and Clinical and Laboratory Data in Infants with Hypertrophic Pyloric Stenosis? (27011465)
2015
35
Association between NKX2-5 rs29784 and infantile hypertrophic pyloric stenosis in Chinese Han population. (25932253)
2015
36
Epidermolysis Bullosa with Hypertrophic Pyloric Stenosis in a Newborn. (26500857)
2015
37
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
38
How should the pyloric submucosal mass coexisting with hypertrophic pyloric stenosis be treated?: a case of pyloric ectopic pancreas with hypertrophic pyloric stenosis. (25349837)
2014
39
Hypertrophic Pyloric Stenosis developing In a Patient Operated for Patent Urachus - A Case Report. (25057473)
2014
40
Maternal and pregnancy characteristics and risk of infantile hypertrophic pyloric stenosis. (25092081)
2014
41
Hypertrophic pyloric stenosis in infants: is it a congenital or acquired disorder? Reflections on 2 cases. (25332858)
2014
42
Peristaltic waves in infantile hypertrophic pyloric stenosis. (24112865)
2014
43
Hypertrophic pyloric stenosis following repair of esophageal atresia and tracheo-esophageal fistula. (26023501)
2014
44
Balancing competing risks: perinatal exposure to macrolides increases the risk of infantile hypertrophic pyloric stenosis. (25121565)
2014
45
Surgeon as Educator: Bedside Ultrasound in Hypertrophic Pyloric Stenosis. (24931414)
2014
46
Hyperplastic Gastric Polyps in an Infant, Mimicking Infantile Hypertrophic Pyloric Stenosis - A Case Report and Review of the Literature. (24814626)
2014
47
Hypertrophic pyloric stenosis in twins; genetic or environmental factors. (24724922)
2014
48
Eosinophilic gastritis with gastric outlet obstruction mimicking infantile hypertrophic pyloric stenosis. (25222812)
2014
49
Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study. (24618148)
2014
50
Environmental pesticides increase the risk of developing hypertrophic pyloric stenosis. (25783294)
2014

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8TRPC5, TRPC6
29.7DMD, NOS1
3
Show member pathways
8.7NKX2-5, NTF4, NTRK3
48.6NOS1, NTRK3, RET, TRPC6

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Cellular components related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451219.0DMD, NOS1, RET, TRPC5

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:005511710.5NKX2-5, NOS1
2manganese ion transportGO:000682810.4TRPC5, TRPC6
3negative regulation of dendrite morphogenesisGO:005077410.4TRPC5, TRPC6
4cardiac muscle contractionGO:006004810.4DMD, NKX2-5
5positive regulation of peptidyl-threonine phosphorylationGO:001080010.3TRPC5, TRPC6
6regulation of cytosolic calcium ion concentrationGO:005148010.3TRPC5, TRPC6
7regulation of ryanodine-sensitive calcium-release channel activityGO:006031410.3DMD, NOS1
8innervationGO:006038410.1NTF4, RET
9agingGO:000756810.0DMD, NOS1, TRPC6
10neuron differentiationGO:003018210.0RET, TRPC5, TRPC6
11mechanoreceptor differentiationGO:00424909.7NTF4, NTRK3
12positive regulation of neuron differentiationGO:00456669.6DMD, NKX2-5, TRPC5, TRPC6
13transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071698.6NTF4, NTRK3, RET

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1actinin bindingGO:004280510.3TRPC5, TRPC6
2clathrin bindingGO:003027610.1TRPC5, TRPC6
3inositol 1,4,5 trisphosphate bindingGO:007067910.0TRPC5, TRPC6
4store-operated calcium channel activityGO:00152799.8TRPC5, TRPC6

Sources for Hypertrophic Pyloric Stenosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet