Hypertrophic Pyloric Stenosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Disease Ontology:¹⁰ A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and acquired gastric outlet stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways are TRP channels and Cardiomyocyte Differentiation through BMP Receptors. Affiliated tissues include breast, lung and prostate, and related mouse phenotypes are respiratory system and behavior/neurological.

Related Diseases for Hypertrophic Pyloric Stenosis

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3	Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5	Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)

id	Related Disease	Score	Top Affiliating Genes
1	pyloric stenosis	27.8	GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
2	acquired gastric outlet stenosis	11.8
3	esophagitis	10.4
4	ileitis	10.3	GDNF, NOS1
5	esophageal atresia	10.3
6	pylorospasm	10.3
7	chronic orthostatic intolerance	10.3	IGF1, NOS1
8	autoimmune gastrointestinal dysmotility	10.2
9	neuronitis	10.2
10	tracheoesophageal fistula	10.2
11	central hypoventilation syndrome, congenital	10.2	GDNF, RET
12	parametritis	10.2	GDNF, RET
13	pertussis	10.2
14	gilbert syndrome	10.2
15	focal epithelial hyperplasia	10.1	GDNF, RET
16	shprintzen-goldberg syndrome	10.1	GDNF, RET
17	multiple endocrine neoplasia iib	10.1	GDNF, RET
18	heritable pulmonary arterial hypertension	10.1	GDNF, RET
19	bacterial esophagitis	10.1	IGF1, RET
20	hirschsprung disease 1	10.1	GDNF, RET
21	gastroenteritis	10.1
22	adenomyoma	10.1
23	congenital diaphragmatic hernia	10.1
24	eosinophilic gastroenteritis	10.1
25	pancreatitis	10.1
26	duodenitis	10.1
27	achalasia	10.1
28	anal spasm	10.1	GDNF, RET
29	preretinal fibrosis	10.0	GDNF, RET
30	myopathy with deficiency of iron-sulfur cluster assembly enzyme	10.0	GDNF, RET
31	afferent loop syndrome	10.0	GDNF, RET
32	transient arthritis	9.9	GDNF, NOS1, RET
33	muscle hypertrophy	9.9
34	sudden infant death syndrome	9.9
35	cystic fibrosis	9.9
36	citrullinemia	9.9
37	phenylketonuria	9.9
38	gastroesophageal reflux	9.9
39	insulin-like growth factor i	9.9
40	androgen insensitivity	9.9
41	pulmonary hypertension	9.9
42	congenital hypothyroidism	9.9
43	hydronephrosis	9.9
44	heart disease	9.9
45	nephrocalcinosis	9.9
46	down syndrome	9.9
47	hypothyroidism	9.9
48	ventricular septal defect	9.9
49	congenital heart disease	9.9
50	intestinal perforation	9.9

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:

Symptoms for Hypertrophic Pyloric Stenosis

Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library
See all MalaCards sources

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis	Completed	NCT00195949	Phase 3
2	The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood	Not yet recruiting	NCT01159509

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

Anatomical Context for Hypertrophic Pyloric Stenosis

Sources:
³³MalaCards
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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

³³

Breast, Lung, Prostate, Liver, Bone, Thyroid, Spinal cord

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

Sources:
³⁸MGI
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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system	MP:0005388	8.7	HMOX2, IGF1, NKX2-5, NOS1, RET
2	behavior/neurological	MP:0005386	7.9	GDNF, HMOX2, MBNL1, NOS1, RET, TRPC5
3	cellular	MP:0005384	7.3	GDNF, IGF1, NKX2-5, NOS1, RET, TRPC5
4	muscle	MP:0005369	7.3	GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
5	cardiovascular system	MP:0005385	7.3	GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
6	nervous system	MP:0003631	6.2	GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1

Publications for Hypertrophic Pyloric Stenosis

Sources:
⁵⁴PubMed
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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50) (show all 541)

id	Title	Authors	Year
1	Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. (26944185)	Wayne C.... Nasr A.	2016
2	Adult idiopathic hypertrophic pyloric stenosis. (26154756)	Lin H.P.... Kuo C.Y.	2015
3	Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)	Dassinger M.... Fuchs G.J.	2014
4	Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)	Taylor N.D.... Holland A.J.	2013
5	Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)	McAteer J.P.... Goldin A.B.	2013
6	Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)	Pappano D.	2011
7	The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)	Serra A.... Fitze G.	2011
8	Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)	Zhang Z.B.	2010
9	Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)	Brouwers A.G.... Waals-Van de Wal C.M.	2009
10	Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)	Gilet A.G.... Cohen H.L.	2008
11	Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)	Ward E.... Pohl J.	2008
12	Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)	Muramori K.... Kawanami T.	2007
13	Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)	Saur D.... Allescher H.D.	2004
14	Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)	Cooper W.O.... Ray W.A.	2002
15	Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)	Mahon B.E.... Kleiman M.B.	2001
16	Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)	Jenson H.B.... Puri P.	2001
17	In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)	Hernanz-Schulman M.... Cywes R.	2001
18	Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)	Tiao M.M.... Liang C.D.	2000
19	Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)	Honein M.A.... Erickson J.D.	1999
20	Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)	Oue T.... Puri P.	1999
21	Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)	Rohrschneider W.K.... TrAPger J.	1998
22	Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)	Yamamoto A.... Kobayashi Y.	1998
23	Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)	Cohen H.L.... Stoane J.M.	1998
24	Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)	Ohshiro K.... Puri P.	1998
25	Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)	Kusafuka T.... Puri P.	1997
26	Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)	Ali K.I.... Haddad M.J.	1996
27	The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)	Neilson D.... Hollman A.S.	1994
28	An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)	Georgeson K.E.... Breaux C.W.	1993
29	The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)	Mitchell L.E.... Risch N.	1993
30	Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)	Dieler R.... Steinau G.	1990
31	Multinodular adult hypertrophic pyloric stenosis. (2584668)	Navab F.... Flores L.	1989
32	Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)	Hansen L.P.... Rasmussen L.	1988
33	Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. (3582407)	SchAofer K.H.... Kramer M.	1987
34	Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)	Vaziri D.M.... Vaziri V.L.	1987
35	Re: Infantile hypertrophic pyloric stenosis. (3744758)	McNicholl B.	1986
36	Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)	Mackay A.J.... Mackellar A.	1986
37	300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)	Leahy P.F.... O'Donnell B.	1986
38	The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)	LaFerla G.... Drainer I.K.	1986
39	Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)	Whalen T.V.... Asch M.J.	1985
40	The reliable sonographic diagnosis of hypertrophic pyloric stenosis. (6427283)	Wilson D.A.... Vanhoutte J.J.	1984
41	Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)	Blumhagen J.D.... Noble H.G.	1983
42	Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)	Markowitz R.I.... Capitanio M.A.	1982
43	Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)	Laidin A.Z.... Nor M.M.	1982
44	Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)	Eckstein H.B.... Agrawal M.	1982
45	X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)	Garcia Perez A.... Crespo M.	1981
46	The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)	Wesley J.R.... Vinik A.I.	1980
47	Idiopathic hypertrophic pyloric stenosis in adults. (7401003)	Suman R.K.	1980
48	Late presentation of hypertrophic pyloric stenosis. (470691)	James C.A.... Kern I.B.	1979
49	Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)	Bleicher M.A.... Track N.S.	1979
50	(23375452)

Genes related to Hypertrophic Pyloric Stenosis

Sources:
²⁰GeneCards, ¹²DISEASES
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Genes related to Hypertrophic Pyloric Stenosis:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	NOS1	Nitric Oxide Synthase 1	24.80	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
2	NKX2-5	NK2 Homeobox 5	24.00	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
3	MBNL1	Muscleblind Like Splicing Regulator 1	23.61	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
4	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	23.51	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
5	TRPC5	Transient Receptor Potential Cation Channel Subfamily C Member 5	23.25	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
6	RET	Ret Proto-Oncogene	22.42	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
7	HMOX2	Heme Oxygenase 2	22.25	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
8	IGF1	Insulin Like Growth Factor 1	21.98	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
9	TYMP	Thymidine Phosphorylase	21.74	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
10	GDNF	Glial Cell Derived Neurotrophic Factor	18.16	GeneCards inferred via : Publications (show sections)

Variations for Hypertrophic Pyloric Stenosis

Expression for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
¹⁷Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
⁵²PathCards, ⁵⁷Reactome, ⁵⁵QIAGEN, ³⁹NCBI BioSystems Database, ⁶²Thomson Reuters, ⁵⁶R&D Systems
See all MalaCards sources

Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	TRP channels⁵⁷	9.7	TRPC5, TRPC6
2	Cardiomyocyte Differentiation through BMP Receptors⁵⁵	9.6	GDNF, NKX2-5
3	Cardiac Progenitor Differentiation³⁹	9.5	IGF1, NKX2-5
4	Signaling events regulated by Ret tyrosine kinase³⁹	9.5	GDNF, RET
5	G-protein signaling_H-RAS regulation pathway⁶²	9.5	GDNF, RET
6	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁶	9.0	GDNF, IGF1, NKX2-5

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
¹⁸Gene Ontology
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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	manganese ion transport	GO:0006828	10.2	TRPC5, TRPC6
2	regulation of cardiac muscle contraction	GO:0055117	10.2	NKX2-5, NOS1
3	response to nutrient levels	GO:0031667	10.1	IGF1, NOS1
4	regulation of cardiac conduction	GO:1903779	9.9	NKX2-5, NOS1
5	response to heat	GO:0009408	9.3	IGF1, NOS1
6	axon guidance	GO:0007411	9.2	GDNF, TRPC5, TRPC6
7	positive regulation of transcription, DNA-templated	GO:0045893	9.2	IGF1, NKX2-5, NOS1, RET
8	positive regulation of cell proliferation	GO:0008284	9.1	GDNF, IGF1, NKX2-5
9	negative regulation of apoptotic process	GO:0043066	8.9	GDNF, IGF1, NKX2-5, NOS1
10	positive regulation of transcription from RNA polymerase II promoter	GO:0045944	8.6	GDNF, IGF1, NKX2-5, NOS1

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	inositol 1,4,5 trisphosphate binding	GO:0070679	9.7	TRPC5, TRPC6

Sources for Hypertrophic Pyloric Stenosis

¹BitterDB

²CDC

³Cell Signaling Technology

⁴ClinicalTrials

⁵Clinvar

⁶Cochrane Library

⁷Cosmic

⁸dbSNP

⁹DGIdb

¹⁰Disease Ontology

¹¹diseasecard

¹²DISEASES

¹³DrugBank

¹⁴ExPASy

¹⁵FDA

¹⁶FMA

¹⁷Gene Expression Omnibus DataSets

¹⁸Gene Ontology

¹⁹GeneAnalytics

²⁰GeneCards

²¹GeneReviews

²²GeneTests

²³Genetics Home Reference

²⁴GTR

²⁵HGMD

²⁶HMDB

²⁷ICD10

²⁸ICD10 via Orphanet

²⁹ICD9CM

³⁰IUPHAR

³¹KEGG

³²LifeMap Discovery®

³³MalaCards

³⁴MedGen

³⁵MedlinePlus

³⁶MeSH

³⁷MESH via Orphanet

³⁸MGI

³⁹NCBI BioSystems Database

⁴⁰NCBI Bookshelf

⁴¹NCI

⁴²NCIt

⁴³NDF-RT

⁴⁴NIH Clinical Center

⁴⁵NIH Rare Diseases

⁴⁶NINDS

⁴⁷Novoseek

⁴⁸Novus Biologicals

⁴⁹OMIM

⁵⁰OMIM via Orphanet

⁵¹Orphanet

⁵²PathCards

⁵³PharmGKB

⁵⁴PubMed

⁵⁵QIAGEN

⁵⁶R&D Systems

⁵⁷Reactome

⁵⁸SinoBiological

⁵⁹SNOMED-CT

⁶⁰SNOMED-CT via Orphanet

⁶¹The Human Phenotype Ontology

⁶²Thomson Reuters

⁶³Tocris Bioscience

⁶⁴Tumor Gene Family of Databases

⁶⁵UMLS

⁶⁶UMLS via Orphanet

⁶⁷UniProtKB/Swiss-Prot

⁶⁸Wikipedia

MCID: HYP009 MIFTS: 42	Hypertrophic Pyloric Stenosis malady Category: Gastrointestinal diseases
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Hypertrophic Pyloric Stenosis malady

Aliases & Classifications for Hypertrophic Pyloric Stenosis

Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

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Summaries for Hypertrophic Pyloric Stenosis