MCID: HYP009
MIFTS: 43

Hypertrophic Pyloric Stenosis malady

Gastrointestinal diseases category

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 8
Congenital Hypertrophic Pyloric Stenosis 8
 
Infantile Stricture of Pylorus 8
Pyloric Stenosis, Hypertrophic 61


Classifications:



External Ids:

Disease Ontology8 DOID:12638
MeSH33 D046248
SNOMED-CT56 48644003
ICD9CM27 750.5
ICD1025 Q40.0

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:8 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to pyloric stenosis and esophagitis. An important gene associated with Hypertrophic Pyloric Stenosis is NKX2-5 (NK2 homeobox 5), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and imipramine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, pancreas and breast, and related mouse phenotypes are respiratory system and digestive/alimentary.

Related Diseases for Hypertrophic Pyloric Stenosis

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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1pyloric stenosis33.0NOS1
2esophagitis10.6
3pylorospasm10.6
4acquired gastric outlet stenosis10.6
5neuronitis10.5
6esophageal atresia10.5
7gilbert syndrome10.5
8pertussis10.5
9tracheoesophageal fistula10.5
10gastric outlet obstruction10.5
11eosinophilic gastroenteritis10.4
12duodenitis10.4
13achalasia10.4
14congenital diaphragmatic hernia10.4
15gastroenteritis10.4
16neonatal jaundice10.4UGT1A1
17hirschsprung disease 110.3GDNF
18muscle hypertrophy10.2
19sudden infant death syndrome10.2
20cystic fibrosis10.2
21phenylketonuria10.2
22gastroesophageal reflux10.2
23insulin-like growth factor i10.2
24citrullinemia10.2
25androgen insensitivity10.2
26pulmonary hypertension10.2
27dyspepsia10.2
28eosinophilic gastritis10.2
29polyhydramnios10.2
30polycystic kidney disease10.2
31gastroduodenitis10.2
32nephrocalcinosis10.2
33cutis laxa10.2
34gastric dilatation10.2
35congenital hypothyroidism10.2
36hydronephrosis10.2
37down syndrome10.2
38congenital heart disease10.2
39congenital mesoblastic nephroma10.2
40conjunctivitis10.2
41gastritis10.2
42hypothyroidism10.2
43kidney disease10.2
44neuropathy10.2
45pancreatitis10.2
46ventricular septal defect10.2
47esophageal atresia/tracheoesophageal fistula10.2
48autoimmune gastrointestinal dysmotility10.2
49gastric duplication cysts10.2
50jejunal atresia10.2

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Drug clinical trials:

Search ClinicalTrials for Hypertrophic Pyloric Stenosis

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

31
Smooth muscle, Pancreas, Breast, Brain, Heart, Kidney, Liver, Lung, Testes, Endothelial

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4NGFR, NKX2-5, HMOX2, NOS1
2MP:00053818.2NOS1, HMOX2, NGFR, GDNF
3MP:00053878.2NOS1, NKX2-5, NGFR, GDNF
4MP:00053978.1GDNF, NGFR, NKX2-5, NOS1
5MP:00053697.8NOS1, HMOX2, NKX2-5, NGFR, GDNF
6MP:00053857.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
7MP:00053867.8GDNF, NGFR, HMOX2, NOS1
8MP:00036317.7GDNF, NGFR, NKX2-5, HMOX2, NOS1
9MP:00107687.6NOS1, HMOX2, NKX2-5, NGFR, GDNF

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
2
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
3
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
4
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
5
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
6
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
7
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
8
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
9
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
10
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
11
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
12
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
13
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
16
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
17
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
18
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
19
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
20
Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)
1999
21
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
22
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
23
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
24
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
25
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
26
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
27
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
28
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
29
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
30
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
31
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
32
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
33
Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. (3582407)
1987
34
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
35
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
36
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
37
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
38
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
39
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
40
The reliable sonographic diagnosis of hypertrophic pyloric stenosis. (6427283)
1984
41
Incidence of infantile hypertrophic pyloric stenosis. (6143193)
1984
42
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
43
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
44
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
45
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
46
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
47
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
48
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
49
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
50
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.4HMOX2, UGT1A1
2
Show member pathways
8.6NOS1, NGFR, GDNF
38.6NOS1, NGFR, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

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Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 44)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin449.9HMOX2, NOS1
2imipramine44 28 50 24 1113.9UGT1A1, NOS1
3hydroxyurea44 50 1111.8NOS1, UGT1A1
4mptp449.8NOS1, GDNF
5morphine44 50 28 1112.8UGT1A1, NOS1
6capsaicin44 2810.8GDNF, NOS1
7guanylate449.7HMOX2, NOS1
8cgmp44 2810.6HMOX2, NOS1
9carbon449.6HMOX2, NOS1
10cocaine44 1110.5GDNF, NOS1
11peroxynitrite449.5NGFR, NOS1
12FAD249.5NOS1, HMOX2
13heme28 24 1111.5NOS1, HMOX2
14ibuprofen44 28 50 24 1113.5UGT1A1, NGFR
15ganglioside449.4GDNF, NGFR
16dbc-amp449.3GDNF, NGFR
17catecholamine449.3NGFR, GDNF
18genistein44 28 60 1 24 1114.3NOS1, GDNF, UGT1A1
19aspartate449.2NOS1, GDNF, UGT1A1
20arginine449.2NOS1, HMOX2, UGT1A1
21nicotine44 28 50 1112.1NOS1, NGFR, UGT1A1
22indomethacin44 28 60 1112.1NOS1, NGFR, UGT1A1
23nadph44 2410.1NGFR, NOS1, HMOX2
24alanine449.1NOS1, UGT1A1, GDNF
25choline44 24 1111.0NGFR, GDNF, NOS1
26gaba449.0GDNF, NOS1, NGFR
27nmda44 2810.0GDNF, NOS1, NGFR
28progesterone44 28 60 24 1112.9UGT1A1, NGFR, HMOX2
29zinc44 249.9NGFR, GDNF, NKX2-5
30vegf448.9NOS1, GDNF, NGFR
31serine448.5NGFR, NKX2-5, GDNF, NOS1
32acetylcholine44 50 28 24 1112.5GDNF, HMOX2, NOS1, NGFR
33dopamine44 28 24 1111.5HMOX2, NGFR, GDNF, NOS1
34superoxide44 249.5HMOX2, GDNF, NGFR, NOS1
35cysteine448.5NOS1, NGFR, GDNF
36dexamethasone44 50 28 1111.5NOS1, GDNF, UGT1A1, NGFR
37glutamate448.5GDNF, NGFR, HMOX2, NOS1
38oxygen44 249.5GDNF, NGFR, NOS1, HMOX2
39retinoic acid44 249.5GDNF, UGT1A1, NGFR, NOS1
40tyrosine448.3NGFR, GDNF, UGT1A1, HMOX2
41calcium44 50 24 1111.3GDNF, NOS1, NGFR, HMOX2
42glucose448.2NGFR, GDNF, HMOX2
43nitric oxide44 24 1110.1NOS1, NKX2-5, NGFR, GDNF, HMOX2
44estrogen448.0HMOX2, NGFR, UGT1A1, GDNF, NOS1

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:00551179.7NOS1, NKX2-5
2heme catabolic processGO:00421679.5HMOX2, UGT1A1
3response to hypoxiaGO:00016669.5NOS1, HMOX2
4porphyrin-containing compound metabolic processGO:00067789.4HMOX2, UGT1A1
5positive regulation of transcription from RNA polymerase II promoterGO:00459448.7NOS1, NKX2-5, GDNF
6negative regulation of apoptotic processGO:00430668.5GDNF, NGFR, NKX2-5

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:00428038.9NKX2-5, UGT1A1, GDNF

Sources for Hypertrophic Pyloric Stenosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet