MCID: HYP009
MIFTS: 50

Hypertrophic Pyloric Stenosis malady

Gastrointestinal diseases category

Summaries for Hypertrophic Pyloric Stenosis

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to pyloric stenosis and esophagitis. An important gene associated with Hypertrophic Pyloric Stenosis is HMOX2 (heme oxygenase (decycling) 2), and among its related pathways are Spinal Cord Injury and heme degradation. The compounds estrogen and kb-r7943 have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, breast and heart, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Hypertrophic Pyloric Stenosis

About this section
Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

hypertrophic pyloric stenosis 8
congenital hypertrophic pyloric stenosis 8
infantile stricture of pylorus 8
pyloric stenosis, hypertrophic 60


External Ids:

Disease Ontology8 DOID:12638
ICD9CM27 750.5
SNOMED-CT56 48644003
MeSH34 D046248
ICD1025 Q40.0

Related Diseases for Hypertrophic Pyloric Stenosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Clinical Features for Hypertrophic Pyloric Stenosis

About this section

Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hypertrophic Pyloric Stenosis

Drug clinical trials:

Search ClinicalTrials for Hypertrophic Pyloric Stenosis

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

Search CenterWatch for Hypertrophic Pyloric Stenosis

Genetic Tests for Hypertrophic Pyloric Stenosis

About this section

Anatomical Context for Hypertrophic Pyloric Stenosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

32
Smooth muscle, Breast, Heart, Kidney, Liver, Lung, Pancreas, Testes, Endothelial

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7ELN, MBNL1, DES, NKX2-5, TRPC6, NGFR
2MP:00053858.3DES, NKX2-5, TRPC1, TRPC6, NGFR, GDNF
3MP:00053768.2DES, NKX2-5, TRPC5, TYMP, NGFR, SIK3
4MP:00053868.1S100B, DES, TRPC1, TRPC5, TRPC6, NGFR

Publications for Hypertrophic Pyloric Stenosis

About this section
Sources:
50PubMed
See all sources

Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Hypertrophic pyloric stenosis in a newborn: a diagnostic dilemma. (21636874)
2011
2
Infantile hypertrophic pyloric stenosis before 3 weeks of age in infants and preterm babies. (20557472)
2011
3
Idiopathic non-hypertrophic pyloric stenosis in an infant successfully treated via endoscopic approach. (21191516)
2010
4
Malrotation associated with infantile hypertrophic pyloric stenosis in a neonate. (19208071)
2009
5
Rapid correction of metabolic alkalosis in hypertrophic pyloric stenosis with intravenous cimetidine: preliminary results. (19169692)
2009
6
Feasibility of emergency physician diagnosis of hypertrophic pyloric stenosis using point-of-care ultrasound: a multi-center case series. (18572347)
2009
7
Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing. (19701773)
2009
8
Absence of motilin gene mutations in infantile hypertrophic pyloric stenosis. (18358279)
2008
9
Linkage of monogenic infantile hypertrophic pyloric stenosis to chromosome 16q24. (18478043)
2008
10
Hypertrophic pyloric stenosis in mono-ovular extremely preterm twins after use of erythromycin. (19261125)
2008
11
Adenomyoma of the stomach mimicking infantile hypertrophic pyloric stenosis. (18022419)
2007
12
Choice of incision: the experience and evolution of surgical management of infantile hypertrophic pyloric stenosis. (17362191)
2007
13
Are young infants treated with erythromycin at risk for developing hypertrophic pyloric stenosis? (17337692)
2007
14
Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: impact of experience on the results in 182 cases. (15108114)
2004
15
Penile agenesis and congenital hypertrophic pyloric stenosis: an association or a random coexistence? (15368696)
2004
16
Muscle thickness in infants hypertrophic pyloric stenosis. (12916445)
2003
17
Recessive X-linked ichthyosis associated with hypertrophic pyloric stenosis: a chance occurrence? (12558636)
2003
18
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
19
Ultrasonographic follow-up of infantile hypertrophic pyloric stenosis after pyloromyotomy: a controlled prospective study. (12548489)
2002
20
Ultrasound diagnosis of infantile hypertrophic pyloric stenosis: determinants of pyloric length and the effect of prematurity. (11977948)
2002
21
A possible role of the plasmalemmal cytoskeleton, nitric oxide synthase, and innervation in infantile hypertrophic pyloric stenosis. (10663874)
2000
22
Should infantile hypertrophic pyloric stenosis be managed in specialist centres? (11006659)
2000
23
Is Helicobacter pylori a cause of infantile hypertrophic pyloric stenosis? (10904427)
2000
24
Infantile hypertrophic pyloric stenosis: delays in diagnosis and overutilization of imaging modalities. (9915537)
1999
25
An uncommon association of H-type tracheoesophageal fistula with infantile hypertrophic pyloric stenosis. (10770691)
1999
26
Hypertrophic pyloric stenosis in infants following pertussis prophylaxis with erythromycin--Knoxville, Tennessee, 1999. (10634345)
1999
27
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
28
Coexisting hyperplastic antral polyp and hypertrophic pyloric stenosis. (9388280)
1997
29
Changing patterns of diagnosis and treatment of infantile hypertrophic pyloric stenosis: a clinical audit of 303 patients. (8986971)
1996
30
Lack of intestinal pacemaker (C-KIT-positive) cells in infantile hypertrophic pyloric stenosis. (8632295)
1996
31
Medical treatment of idiopathic hypertrophic pyloric stenosis: should we marinate or slice the "olive"? (8956174)
1996
32
Breast feeding and hypertrophic pyloric stenosis: population based case-control study. (8605461)
1996
33
Surgical technique of laparoscopic pyloromyotomy for infantile hypertrophic pyloric stenosis. (8520173)
1995
34
Early experience with laparoscopic pyloromyotomy for infantile hypertrophic pyloric stenosis. (7722825)
1995
35
A new technique for laparoscopic repair of hypertrophic pyloric stenosis. (8523228)
1995
36
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
37
Hypertrophic pyloric stenosis in the newborn. (8301497)
1993
38
Renal abnormalities in children with hypertrophic pyloric stenosis--fact or fallacy? (8414755)
1993
39
Comparison of postpyloromyotomy feeding regimens in infantile hypertrophic pyloric stenosis. (1920229)
1991
40
Infantile hypertrophic pyloric stenosis in Dar Es Salaam. (1893403)
1991
41
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
42
Ultrasonic "double track" sign in hypertrophic pyloric stenosis. (3550137)
1987
43
Case study: congenital hypertrophic pyloric stenosis in twins. (3644130)
1987
44
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
45
Problems in diagnosis and treatment of infantile hypertrophic pyloric stenosis. (3982549)
1985
46
Incidence of infantile hypertrophic pyloric stenosis. (6144893)
1984
47
Infantile hypertrophic pyloric stenosis: surgical experience of 24 cases. (7344572)
1981
48
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
49
Six atypical presentations of congenital hypertrophic pyloric stenosis. (761434)
1979
50
Hypertrophic pyloric stenosis following repair of congenital diaphragmatic hernia. (512805)
1979

Genetic Variations for Hypertrophic Pyloric Stenosis

About this section

Expression for genes affiliated with Hypertrophic Pyloric Stenosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypertrophic Pyloric Stenosis

Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
See all sources

Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS1, GDNF, NGFR
2
Hide members
9.8HMOX2, BLVRB, UGT1A1
3
Hide members
9.8HMOX2, BLVRB, UGT1A1
49.7TRPC6, TRPC5, TRPC1
59.7TRPC1, TRPC5, TRPC6
69.7TRPC1, TRPC5, TRPC6
7
Hide members
9.5TRPC1, TRPC5, TRPC6, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

About this section
Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7ELN
2kb-r79432810.3TRPC5, TRPC6
3orcein4410.3S100B, DES, ELN
4gv 1500134410.2GAST, NOS1
5gsmtx-42810.1TRPC6, TRPC5, TRPC1
6skf963652810.1TRPC1, TRPC5, TRPC6
7gd3+2810.1TRPC1, TRPC5, TRPC6
82-aminoethoxydiphenylborane4410.1TRPC6, TRPC5
9la3+2810.0TRPC6, TRPC5, TRPC1
10trimebutine4410.0GAST, MLN
112-apb28 5911.0TRPC1, TRPC5, TRPC6
12ng-nitro-l-arginine4410.0NOS1, BLVRB, GAST
13hematoxylin4410.0S100B, DES, BLVRB, ELN
14catecholamine449.9S100B, BLVRB, NGFR, GDNF
15sodium nitroprusside449.9S100B, BLVRB, NOS1, ELN
16choline44 11 2411.8S100B, BLVRB, NGFR, GDNF, NOS1
17cgmp44 2810.7ELN, NOS1, HMOX2, BLVRB
18ethanol44 49 11 2412.7GDNF, NGFR, BLVRB, DES, S100B
19bromodeoxyuridine449.7S100B, GAST, DES, GDNF
20indomethacin44 59 28 1112.6UGT1A1, BLVRB, TYMP, NGFR, NOS1, ELN
21norepinephrine44 11 2411.6S100B, GAST, DES, GDNF, NOS1
22nicotine44 49 28 1112.6NOS1, NGFR, UGT1A1, GAST
23formaldehyde44 2410.6S100B, DES, BLVRB, TYMP, NOS1, ELN
24actinomycin d449.5DES, TYMP, GDNF, HMOX2, ELN
25gaba449.5S100B, GAST, BLVRB, NGFR, GDNF, NOS1
26carbon449.5BLVRB, HMOX2, NOS1, ELN
27paraffin449.5S100B, DES, BLVRB, TYMP, NGFR, ELN
28histamine44 28 2411.5GAST, MLN, NGFR, NOS1, ELN
29thymidine44 2410.5S100B, GAST, UGT1A1, DES, TYMP, NGFR
30glucose449.5GAST, MLN, TYMP, NGFR, GDNF, HMOX2
31retinoic acid44 2410.4S100B, UGT1A1, DES, NGFR, GDNF, NOS1
32dexamethasone44 49 28 1112.3S100B, GAST, UGT1A1, NGFR, GDNF, NOS1
33creatinine449.3S100B, GAST, DES, TYMP, GDNF, NOS1
34heparin44 28 11 2412.3S100B, GAST, MLN, DES, GDNF, ELN
35cysteine449.3S100B, DES, TYMP, NGFR, GDNF, NOS1
36oxygen44 2410.2S100B, DES, BLVRB, TYMP, NGFR, GDNF
37testosterone44 59 11 2412.2S100B, GAST, UGT1A1, DES, BLVRB, NOS1
38alanine449.2S100B, GAST, UGT1A1, MLN, GDNF, NOS1
39vegf449.2S100B, GAST, DES, TYMP, NGFR, GDNF
40genistein44 28 59 2 11 2414.2UGT1A1, TRPC5, GDNF, NOS1, ELN
41arginine449.1S100B, UGT1A1, MLN, DES, BLVRB, HMOX2
42adenylate449.1S100B, GAST, MLN, DES, BLVRB, GDNF
43glutamate449.1S100B, GAST, BLVRB, NGFR, GDNF, HMOX2
44dopamine44 28 11 2412.1S100B, GAST, MLN, BLVRB, NGFR, GDNF
45progesterone44 59 28 11 2412.9S100B, UGT1A1, MLN, DES, TRPC5, BLVRB
46acetylcholine44 49 28 11 2412.8NOS1, S100B, GAST, MLN, DES, BLVRB
47serine448.7S100B, GAST, MLN, DES, NKX2-5, TYMP
48tyrosine448.6S100B, GAST, UGT1A1, MLN, DES, BLVRB
49nitric oxide44 11 2410.4S100B, MLN, DES, NKX2-5, TRPC1, BLVRB
50calcium44 49 11 2410.8TRPC1, DES, MLN, GAST, S100B, TRPC5

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:05511710.1NOS1, NKX2-5
2heme catabolic processGO:0421679.8HMOX2, BLVRB, UGT1A1
3porphyrin-containing compound metabolic processGO:0067789.7HMOX2, BLVRB, UGT1A1
4axon guidanceGO:0074119.0TRPC1, TRPC5, TRPC6, NGFR, GDNF

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol 1,4,5 trisphosphate bindingGO:0706799.6TRPC6, TRPC5, TRPC1
2store-operated calcium channel activityGO:0152799.4TRPC6, TRPC5, TRPC1
3protein bindingGO:0055157.1NKX2-5, DES, GAST, MBNL1, S100B, TRPC1

Products for genes affiliated with Hypertrophic Pyloric Stenosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertrophic Pyloric Stenosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet