MCID: HYP009
MIFTS: 39

Hypertrophic Pyloric Stenosis malady

Gastrointestinal diseases category

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 10 12
Pyloric Stenosis, Hypertrophic 65 36
 
Congenital Hypertrophic Pyloric Stenosis 10
Infantile Stricture of Pylorus 10


Classifications:



External Ids:

Disease Ontology10 DOID:12638
MeSH36 D046248
SNOMED-CT59 48644003
ICD9CM29 750.5
ICD1027 Q40.0

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:10 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and esophagitis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1 (Neuronal)), and among its related pathways are TRP channels and Muscular Dystrophies and Dystrophin-Glycoprotein Complex. Affiliated tissues include breast, pancreas and smooth muscle, and related mouse phenotypes are digestive/alimentary and vision/eye.

Related Diseases for Hypertrophic Pyloric Stenosis

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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1pyloric stenosis11.6
2esophagitis10.7
3esophageal atresia10.6
4pylorospasm10.6
5acquired gastric outlet stenosis10.6
6neuronitis10.5
7tracheoesophageal fistula10.5
8gilbert syndrome10.5
9pertussis10.5
10ichthyosis10.5
11congenital diaphragmatic hernia10.4
12achalasia10.4
13duodenitis10.4
14eosinophilic gastroenteritis10.4
15gastroenteritis10.4
16gastrointestinal system disease10.4
17stomach disease10.4
18muscle hypertrophy10.2
19sudden infant death syndrome10.2
20cystic fibrosis10.2
21citrullinemia10.2
22phenylketonuria10.2
23gastroesophageal reflux10.2
24insulin-like growth factor i10.2
25androgen insensitivity10.2
26pulmonary hypertension10.2
27dyspepsia10.2
28hydronephrosis10.2
29nephrocalcinosis10.2
30polyhydramnios10.2
31gastroduodenitis10.2
32congenital hypothyroidism10.2
33down syndrome10.2
34cutis laxa10.2
35gastric dilatation10.2
36eosinophilic gastritis10.2
37polycystic kidney disease10.2
38congenital heart disease10.2
39congenital mesoblastic nephroma10.2
40conjunctivitis10.2
41epidermolysis bullosa10.2
42gastritis10.2
43hypothyroidism10.2
44intestinal perforation10.2
45kidney disease10.2
46neuropathy10.2
47non-suppurative otitis media10.2
48pancreatitis10.2
49ventricular septal defect10.2
50esophageal atresia/tracheoesophageal fistula10.2

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric StenosisCompletedNCT00195949Phase 3
2The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in ChildhoodNot yet recruitingNCT01159509

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis


Cochrane evidence based reviews: Pyloric Stenosis, Hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

33
Breast, Pancreas, Smooth muscle, Endothelial, Testes, Liver, Heart

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5DMD, HMOX2, NOS1, RET, SST
2MP:00053918.2DMD, MBNL1, NOS1, NTRK3, TRPC6
3MP:00028738.0DMD, NKX2-5, NOS1, NTRK3, RET, SST
4MP:00053698.0DMD, HMOX2, MBNL1, NKX2-5, NOS1, RET
5MP:00030127.6DMD, NKX2-5, NOS1, NTRK3, RET, SST
6MP:00053887.6DMD, HMOX2, NKX2-5, NOS1, NTRK3, RET
7MP:00053857.4DMD, HMOX2, NKX2-5, NOS1, NTRK3, RET
8MP:00053787.2DMD, NKX2-5, NOS1, NTF4, NTRK3, RET
9MP:00053865.8DMD, HMOX2, NOS1, NTF4, NTRK3, RET
10MP:00036315.8DMD, HMOX2, NKX2-5, NOS1, NTF4, NTRK3

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Adult idiopathic hypertrophic pyloric stenosis. (26154756)
2015
2
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
3
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
4
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
5
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
6
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
7
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
8
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
9
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
10
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
11
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
12
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
13
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
14
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
15
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
16
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
17
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
18
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
19
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
20
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
21
Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)
1999
22
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
23
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
24
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
25
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
26
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
27
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
28
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
29
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
30
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
31
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
32
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
33
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
34
Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. (3582407)
1987
35
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
36
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
37
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
38
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
39
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
40
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
41
The reliable sonographic diagnosis of hypertrophic pyloric stenosis. (6427283)
1984
42
Incidence of infantile hypertrophic pyloric stenosis. (6143193)
1984
43
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
44
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
45
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
46
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
47
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
48
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
49
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
50
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TRPC5, TRPC6
29.6DMD, NOS1

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Cellular components related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451219.2DMD, NOS1, RET

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:005511710.3NKX2-5, NOS1
2manganese ion transportGO:000682810.2TRPC5, TRPC6
3innervationGO:006038410.1NTF4, RET
4cytosolic calcium ion homeostasisGO:005148010.1TRPC5, TRPC6
5response to organonitrogen compoundGO:00102439.9NOS1, SST
6response to heatGO:00094089.8NOS1, SST
7mechanoreceptor differentiationGO:00424909.6NTF4, NTRK3
8regulation of ryanodine-sensitive calcium-release channel activityGO:00603149.6DMD, NOS1
9cardiac muscle contractionGO:00600489.3DMD, NKX2-5
10positive regulation of gene expressionGO:00106288.8NKX2-5, NTRK3, RET

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:00152799.8TRPC5, TRPC6
2inositol 1,4,5 trisphosphate bindingGO:00706799.5TRPC5, TRPC6
3transmembrane receptor protein tyrosine kinase activityGO:00047149.2NTRK3, RET

Sources for Hypertrophic Pyloric Stenosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet