MCID: HYP009
MIFTS: 50

Hypertrophic Pyloric Stenosis malady

Gastrointestinal diseases category
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Summaries for Hypertrophic Pyloric Stenosis

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MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to pyloric stenosis and hirschsprung's disease. An important gene associated with Hypertrophic Pyloric Stenosis is NKX2-5 (NK2 homeobox 5), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and imipramine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, pancreas and breast, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Hypertrophic Pyloric Stenosis, Aliases & Descriptions:

Name: Hypertrophic Pyloric Stenosis 8
Congenital Hypertrophic Pyloric Stenosis 8 62
 
Infantile Stricture of Pylorus 8
Pyloric Stenosis, Hypertrophic 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:12638
MeSH34 D046248
SNOMED-CT57 48644003
ICD9CM27 750.5
ICD1025 Q40.0

Related Diseases for Hypertrophic Pyloric Stenosis

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Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Drug clinical trials:

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Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

32
Smooth muscle, Pancreas, Breast, Heart, Kidney, Liver, Lung, Testes, Endothelial

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4NGFR, NKX2-5, HMOX2, NOS1
2MP:00053818.2NOS1, HMOX2, NGFR, GDNF
3MP:00053878.2NOS1, NKX2-5, NGFR, GDNF
4MP:00053978.1GDNF, NGFR, NKX2-5, NOS1
5MP:00053697.8NOS1, HMOX2, NKX2-5, NGFR, GDNF
6MP:00053857.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
7MP:00053867.8GDNF, NGFR, HMOX2, NOS1
8MP:00036317.7GDNF, NGFR, NKX2-5, HMOX2, NOS1
9MP:00107687.6NOS1, HMOX2, NKX2-5, NGFR, GDNF

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
2
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
3
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
4
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
5
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
6
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
7
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
8
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
9
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
10
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
11
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
12
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
13
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
16
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
17
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
18
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
19
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
20
Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)
1999
21
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
22
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
23
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
24
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
25
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
26
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
27
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
28
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
29
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
30
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
31
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
32
Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. (3582407)
1987
33
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
34
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
35
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
36
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
37
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
38
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
39
The reliable sonographic diagnosis of hypertrophic pyloric stenosis. (6427283)
1984
40
Incidence of infantile hypertrophic pyloric stenosis. (6143193)
1984
41
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
42
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
43
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
44
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
45
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
46
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
47
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
48
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
49
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979
50
Esterolytic activity of blood serum in infants with hypertrophic pyloric stenosis. (469469)
1979

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Expression patterns in normal tissues for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
9.4HMOX2, UGT1A1
2
Show member pathways
8.6NOS1, NGFR, GDNF
38.6NOS1, NGFR, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

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Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin449.9HMOX2, NOS1
2imipramine44 28 50 24 1113.9UGT1A1, NOS1
3hydroxyurea44 50 1111.8UGT1A1, NOS1
4mptp449.8NOS1, GDNF
5morphine44 50 28 1112.8UGT1A1, NOS1
6capsaicin44 2810.8GDNF, NOS1
7guanylate449.7HMOX2, NOS1
8cgmp44 2810.6NOS1, HMOX2
9carbon449.6NOS1, HMOX2
10cocaine44 1110.5GDNF, NOS1
11peroxynitrite449.5NGFR, NOS1
12FAD249.5NOS1, HMOX2
13heme28 24 1111.5NOS1, HMOX2
14ibuprofen44 28 50 24 1113.5NGFR, UGT1A1
15ganglioside449.4NGFR, GDNF
16dbc-amp449.3NGFR, GDNF
17catecholamine449.3NGFR, GDNF
18genistein44 28 61 2 24 1114.3GDNF, UGT1A1, NOS1
19aspartate449.2GDNF, UGT1A1, NOS1
20arginine449.2NOS1, HMOX2, UGT1A1
21nicotine44 28 50 1112.1NOS1, NGFR, UGT1A1
22indomethacin44 28 61 1112.1NOS1, NGFR, UGT1A1
23nadph44 2410.1NOS1, HMOX2, NGFR
24alanine449.1NOS1, UGT1A1, GDNF
25choline44 24 1111.0GDNF, NGFR, NOS1
26gaba449.0GDNF, NGFR, NOS1
27nmda44 2810.0NOS1, NGFR, GDNF
28progesterone44 28 61 24 1112.9HMOX2, NGFR, UGT1A1
29zinc44 249.9NKX2-5, NGFR, GDNF
30vegf448.9NOS1, NGFR, GDNF
31serine448.5NOS1, NKX2-5, NGFR, GDNF
32acetylcholine44 50 28 24 1112.5NOS1, HMOX2, NGFR, GDNF
33dopamine44 28 24 1111.5GDNF, NGFR, HMOX2, NOS1
34superoxide44 249.5NOS1, HMOX2, NGFR, GDNF
35cysteine448.5GDNF, NGFR, NOS1
36dexamethasone44 50 28 1111.5NOS1, NGFR, UGT1A1, GDNF
37glutamate448.5NOS1, HMOX2, NGFR, GDNF
38oxygen44 249.5NOS1, HMOX2, NGFR, GDNF
39retinoic acid44 249.5GDNF, UGT1A1, NGFR, NOS1
40tyrosine448.3HMOX2, NGFR, UGT1A1, GDNF
41calcium44 50 24 1111.3NOS1, HMOX2, NGFR, GDNF
42glucose448.2HMOX2, NGFR, GDNF
43nitric oxide44 24 1110.1NOS1, HMOX2, NKX2-5, NGFR, GDNF
44estrogen448.0GDNF, UGT1A1, NGFR, HMOX2, NOS1

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:0551179.7NOS1, NKX2-5
2heme catabolic processGO:0421679.5HMOX2, UGT1A1
3response to hypoxiaGO:0016669.5NOS1, HMOX2
4porphyrin-containing compound metabolic processGO:0067789.4HMOX2, UGT1A1
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.7NOS1, NKX2-5, GDNF
6negative regulation of apoptotic processGO:0430668.5GDNF, NGFR, NKX2-5

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.9NKX2-5, UGT1A1, GDNF

Products for genes affiliated with Hypertrophic Pyloric Stenosis

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Sources for Hypertrophic Pyloric Stenosis

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