MCID: HYP009
MIFTS: 49

Hypertrophic Pyloric Stenosis malady

Gastrointestinal diseases category

Summaries for Hypertrophic Pyloric Stenosis

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MalaCards: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to pyloric stenosis and hirschsprung's disease. An important gene associated with Hypertrophic Pyloric Stenosis is NKX2-5 (NK2 homeobox 5), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and imipramine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, breast and liver, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

hypertrophic pyloric stenosis 9
congenital hypertrophic pyloric stenosis 9
infantile stricture of pylorus 9
pyloric stenosis, hypertrophic 63


External Ids:

Disease Ontology9 DOID:12638
MeSH36 D046248
SNOMED-CT59 48644003
ICD9CM28 750.5
ICD1026 Q40.0

Related Diseases for Hypertrophic Pyloric Stenosis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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34MalaCards
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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

34
Smooth muscle, Breast, Liver, Kidney, Lung, Testes, Heart, Endothelial, Pancreas

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4NGFR, NKX2-5, HMOX2, NOS1
2MP:00053818.2NOS1, HMOX2, NGFR, GDNF
3MP:00053878.2NOS1, NKX2-5, NGFR, GDNF
4MP:00053978.1GDNF, NGFR, NKX2-5, NOS1
5MP:00053697.8NOS1, HMOX2, NKX2-5, NGFR, GDNF
6MP:00053857.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
7MP:00053867.8GDNF, NGFR, HMOX2, NOS1
8MP:00036317.7GDNF, NGFR, NKX2-5, HMOX2, NOS1
9MP:00107687.6NOS1, HMOX2, NKX2-5, NGFR, GDNF

Publications for Hypertrophic Pyloric Stenosis

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53PubMed
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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
2
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
3
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
4
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
5
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
6
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
7
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
8
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
9
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
10
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
11
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
12
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
13
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
14
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
15
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
16
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
17
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
18
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
19
Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)
1999
20
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
21
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
22
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
23
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
24
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
25
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
26
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
27
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
28
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
29
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
30
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
31
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
32
Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. (3582407)
1987
33
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
34
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
35
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
36
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
37
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
38
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
39
The reliable sonographic diagnosis of hypertrophic pyloric stenosis. (6427283)
1984
40
Incidence of infantile hypertrophic pyloric stenosis. (6143193)
1984
41
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
42
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
43
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
44
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
45
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
46
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
47
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
48
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
49
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979
50
Esterolytic activity of blood serum in infants with hypertrophic pyloric stenosis. (469469)
1979

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis39
heme degradation39
Heme Biosynthesis39
heme biosynthesis39
heme biosynthesis from uroporphyrinogen-III I39
9.4HMOX2, UGT1A1
2
Show member pathways
8.6NOS1, NGFR, GDNF
38.6NOS1, NGFR, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

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46Novoseek, 30IUPHAR, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
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Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin469.9HMOX2, NOS1
2imipramine46 30 52 25 1213.9UGT1A1, NOS1
3hydroxyurea46 52 1211.8UGT1A1, NOS1
4mptp469.8NOS1, GDNF
5morphine46 52 30 1212.8UGT1A1, NOS1
6capsaicin46 3010.8GDNF, NOS1
7guanylate469.7HMOX2, NOS1
8cgmp46 3010.6NOS1, HMOX2
9carbon469.6NOS1, HMOX2
10cocaine46 1210.5GDNF, NOS1
11peroxynitrite469.5NGFR, NOS1
12FAD259.5NOS1, HMOX2
13heme30 25 1211.5NOS1, HMOX2
14ibuprofen46 30 52 25 1213.5NGFR, UGT1A1
15ganglioside469.4NGFR, GDNF
16dbc-amp469.3NGFR, GDNF
17catecholamine469.3NGFR, GDNF
18genistein46 30 62 3 25 1214.3GDNF, UGT1A1, NOS1
19aspartate469.2GDNF, UGT1A1, NOS1
20arginine469.2NOS1, HMOX2, UGT1A1
21nicotine46 30 52 1212.1NOS1, NGFR, UGT1A1
22indomethacin46 30 62 1212.1NOS1, NGFR, UGT1A1
23nadph46 2510.1NOS1, HMOX2, NGFR
24alanine469.1NOS1, UGT1A1, GDNF
25choline46 25 1211.0GDNF, NGFR, NOS1
26gaba469.0GDNF, NGFR, NOS1
27nmda46 3010.0NOS1, NGFR, GDNF
28progesterone46 30 62 25 1212.9HMOX2, NGFR, UGT1A1
29zinc46 259.9NKX2-5, NGFR, GDNF
30vegf468.9NOS1, NGFR, GDNF
31serine468.5NOS1, NKX2-5, NGFR, GDNF
32acetylcholine46 52 30 25 1212.5NOS1, HMOX2, NGFR, GDNF
33dopamine46 30 25 1211.5GDNF, NGFR, HMOX2, NOS1
34superoxide46 259.5NOS1, HMOX2, NGFR, GDNF
35cysteine468.5GDNF, NGFR, NOS1
36dexamethasone46 52 30 1211.5NOS1, NGFR, UGT1A1, GDNF
37glutamate468.5NOS1, HMOX2, NGFR, GDNF
38oxygen46 259.5NOS1, HMOX2, NGFR, GDNF
39retinoic acid46 259.5GDNF, UGT1A1, NGFR, NOS1
40tyrosine468.3HMOX2, NGFR, UGT1A1, GDNF
41calcium46 52 25 1211.3NOS1, HMOX2, NGFR, GDNF
42glucose468.2HMOX2, NGFR, GDNF
43nitric oxide46 25 1210.1NOS1, HMOX2, NKX2-5, NGFR, GDNF
44estrogen468.0GDNF, UGT1A1, NGFR, HMOX2, NOS1

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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17Gene Ontology
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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:0551179.7NOS1, NKX2-5
2heme catabolic processGO:0421679.5HMOX2, UGT1A1
3response to hypoxiaGO:0016669.5NOS1, HMOX2
4porphyrin-containing compound metabolic processGO:0067789.4HMOX2, UGT1A1
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.7NOS1, NKX2-5, GDNF
6negative regulation of apoptotic processGO:0430668.5GDNF, NGFR, NKX2-5

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.9NKX2-5, UGT1A1, GDNF

Products for genes affiliated with Hypertrophic Pyloric Stenosis

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Sources for Hypertrophic Pyloric Stenosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet