MCID: HYP009
MIFTS: 42

Hypertrophic Pyloric Stenosis malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Hypertrophic Pyloric Stenosis

Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 12 14
Pyloric Stenosis, Hypertrophic 42 69
Congenital or Infantile Stricture of Pylorus 12
Congenital Hypertrophic Pyloric Stenosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12638
ICD10 33 Q40.0
ICD9CM 35 750.5
MeSH 42 D046248
NCIt 47 C98952
SNOMED-CT 64 48644003
UMLS 69 C0700639

Summaries for Hypertrophic Pyloric Stenosis

Disease Ontology : 12 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary : Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to acquired gastric outlet stenosis and pyloric stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Neuroscience and TRP channels. The drugs Epinephrine and Rocuronium have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, heart and breast, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Hypertrophic Pyloric Stenosis

Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Related Disease Score Top Affiliating Genes
1 acquired gastric outlet stenosis 11.7
2 pyloric stenosis 11.5
3 autoimmune gastrointestinal dysmotility 11.1
4 esophagitis 10.2
5 esophageal atresia 10.2
6 pylorospasm 10.1
7 tracheoesophageal fistula 10.1
8 neuronitis 10.1
9 prosthetic joint infection 10.0 DMD NOS1
10 pertussis 10.0
11 gilbert syndrome 10.0
12 ichthyosis 10.0
13 mucositis 10.0
14 ascariasis 10.0 NTRK3 SST
15 cowden syndrome 3 10.0 RET SST
16 achalasia 9.9
17 heart disease 9.9
18 congenital diaphragmatic hernia 9.9
19 eosinophilic gastroenteritis 9.9
20 pancreatitis 9.9
21 gastroenteritis 9.9
22 duodenitis 9.9
23 adenomyoma 9.9
24 cardiomyopathy, familial restrictive, 3 9.9 DMD HMOX2
25 early-onset parkinson disease 9.9 RET SST
26 tooth agenesis, selective, 5 9.8 HMOX2 NOS1 NTRK3 RET
27 hydronephrosis 9.8
28 epidermolysis bullosa 9.8
29 neuropathy 9.8
30 muscle hypertrophy 9.8
31 sudden infant death syndrome 9.8
32 cutis laxa 9.8
33 polycystic kidney disease 9.8
34 cystic fibrosis 9.8
35 gastric dilatation 9.8
36 osteoglophonic dysplasia 9.8
37 gastric duplication cysts 9.8
38 citrullinemia 9.8
39 gastritis 9.8
40 phenylketonuria 9.8
41 nephrocalcinosis 9.8
42 eosinophilic gastritis 9.8
43 endotheliitis 9.8
44 gastroesophageal reflux 9.8
45 patent urachus 9.8
46 insulin-like growth factor i 9.8
47 down syndrome 9.8
48 congenital mesoblastic nephroma 9.8
49 penile agenesis 9.8
50 androgen insensitivity 9.8

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to Hypertrophic Pyloric Stenosis

Symptoms & Phenotypes for Hypertrophic Pyloric Stenosis

MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 DMD HMOX2 MBNL1 NOS1 NTF4 NTRK3
2 cardiovascular system MP:0005385 10.08 DMD HMOX2 MBNL1 NKX2-5 NOS1 NTRK3
3 growth/size/body region MP:0005378 10.03 DMD MBNL1 NKX2-5 NOS1 NTF4 NTRK3
4 mortality/aging MP:0010768 10.02 DMD HMOX2 MBNL1 NKX2-5 NOS1 NTF4
5 homeostasis/metabolism MP:0005376 10.01 NTF4 RET SST TRPC5 DMD HMOX2
6 nervous system MP:0003631 10 DMD HMOX2 MBNL1 NKX2-5 NOS1 NTF4
7 digestive/alimentary MP:0005381 9.93 SST DMD HMOX2 NKX2-5 NOS1 RET
8 muscle MP:0005369 9.87 DMD HMOX2 MBNL1 NKX2-5 NOS1 RET
9 no phenotypic analysis MP:0003012 9.7 SST TRPC5 DMD NKX2-5 NOS1 NTRK3
10 normal MP:0002873 9.43 DMD NKX2-5 NOS1 NTRK3 RET SST
11 respiratory system MP:0005388 9.1 DMD HMOX2 NKX2-5 NOS1 NTRK3 RET

Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

Drugs for Hypertrophic Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Rocuronium Approved 119302-91-9, 143558-00-3 441290
3
Sevoflurane Approved, Vet_approved 28523-86-6 5206
4
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
5
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
6
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
7 Anesthetics
8 Epinephryl borate
9 Racepinephrine
10 Bromides
11 Central Nervous System Depressants

Interventional clinical trials:


id Name Status NCT ID Phase
1 Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis Completed NCT00195949 Phase 3
2 The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood Unknown status NCT01159509
3 Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study Not yet recruiting NCT03095144
4 Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia Not yet recruiting NCT02879292

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

Anatomical Context for Hypertrophic Pyloric Stenosis

MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

39
Smooth Muscle, Heart, Breast, Pancreas, Testes, Endothelial, Cervix

Publications for Hypertrophic Pyloric Stenosis

Articles related to Hypertrophic Pyloric Stenosis:

(show top 50) (show all 554)
id Title Authors Year
1
Recent changes in the features of hypertrophic pyloric stenosis. ( 26615824 )
2016
2
Health disparities in infants with hypertrophic pyloric stenosis. ( 27586849 )
2016
3
Treating idiopathic hypertrophic pyloric stenosis with sequential therapy: A clinical study. ( 27439633 )
2016
4
Optimizing fluid resuscitation in hypertrophic pyloric stenosis. ( 26876090 )
2016
5
Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. ( 27599310 )
2016
6
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )
2016
7
Ultrasound assessment of the gastric contents for the guidance of the anaesthetic strategy in infants with hypertrophic pyloric stenosis: a prospective cohort study. ( 27106968 )
2016
8
Successful combination of endoscopic pyloromyotomy and balloon dilatation for hypertrophic pyloric stenosis in an older child: A novel procedure. ( 27915443 )
2016
9
Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. ( 27655365 )
2016
10
Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. ( 26944185 )
2016
11
Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. ( 27642452 )
2016
12
Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. ( 27669400 )
2016
13
Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. ( 27215474 )
2016
14
Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. ( 27292596 )
2016
15
Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. ( 27506212 )
2016
16
Asymmetric Hypertrophic Pyloric Stenosis with Concurrent Pancreatic Rest Presenting as Gastric Outlet Obstruction. ( 27179550 )
2016
17
The cervix sign and other sonographic signs of hypertrophic pyloric stenosis. ( 27315074 )
2016
18
Adult idiopathic hypertrophic pyloric stenosis. ( 27362602 )
2016
19
Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease. ( 27528563 )
2016
20
A randomized trial to assess advancement of enteral feedings following surgery for hypertrophic pyloric stenosis. ( 27829521 )
2016
21
Is there any correlation between radiologic findings and eradication of symptoms after pyloromyotomy in hypertrophic pyloric stenosis? ( 27251656 )
2016
22
A novel missense mutation in the transcription factor FOXF1 co-segregating with infantile hypertrophic pyloric stenosis in the extended pedigree linked to IHPS5 on chromosome 16q24. ( 27855150 )
2016
23
The use of ultrasonography in infantile hypertrophic pyloric stenosis: does the patient's age and weight affect pyloric size and pyloric ratio? ( 25745654 )
2015
24
Birth outcomes of male and female patients with infantile hypertrophic pyloric stenosis - a population-based case-control study. ( 26135791 )
2015
25
Brain oxygenation during laparoscopic correction of hypertrophic pyloric stenosis. ( 25768674 )
2015
26
Incidence and Concurrent Laparoscopic Repair of Hypertrophic Pyloric Stenosis and Patent Processus Vaginalis. ( 25836622 )
2015
27
Infantile hypertrophic pyloric stenosis at a tertiary care hospital in Tanzania: a surgical experience with 102 patients over a 5-year period. ( 26581339 )
2015
28
Ultrasound-guided paravertebral block for pyloromyotomy in 3 neonates with congenital hypertrophic pyloric stenosis. ( 26123148 )
2015
29
Maternal Factors in the Origin of Infantile Hypertrophic Pyloric Stenosis - a Population-based Case-control Study. ( 26394719 )
2015
30
Spontaneous Intestinal Perforation and Infantile Hypertrophic Pyloric Stenosis in a Preterm Neonate: A Linked Etiopathogenesis? ( 26055488 )
2015
31
Infantile Hypertrophic Pyloric Stenosis in Postoperative Esophageal Atresia with Tracheoesophageal Fistula. ( 26290814 )
2015
32
Adult idiopathic hypertrophic pyloric stenosis. ( 26154756 )
2015
33
Epidermolysis Bullosa with Hypertrophic Pyloric Stenosis in a Newborn. ( 26500857 )
2015
34
Association between NKX2-5 rs29784 and infantile hypertrophic pyloric stenosis in Chinese Han population. ( 25932253 )
2015
35
Association of prematurity with the development of infantile hypertrophic pyloric stenosis. ( 25950452 )
2015
36
Is There a Relation Between Pyloric Muscle Thickness and Clinical and Laboratory Data in Infants with Hypertrophic Pyloric Stenosis? ( 27011465 )
2015
37
How should the pyloric submucosal mass coexisting with hypertrophic pyloric stenosis be treated?: a case of pyloric ectopic pancreas with hypertrophic pyloric stenosis. ( 25349837 )
2014
38
Hyperplastic Gastric Polyps in an Infant, Mimicking Infantile Hypertrophic Pyloric Stenosis - A Case Report and Review of the Literature. ( 24814626 )
2014
39
Hypertrophic Pyloric Stenosis developing In a Patient Operated for Patent Urachus - A Case Report. ( 25057473 )
2014
40
Peristaltic waves in infantile hypertrophic pyloric stenosis. ( 24112865 )
2014
41
Balancing competing risks: perinatal exposure to macrolides increases the risk of infantile hypertrophic pyloric stenosis. ( 25121565 )
2014
42
Transient hypertrophic pyloric stenosis due to prostoglandin infusion. ( 25263728 )
2014
43
The difficulty in evaluating all findings in study on use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis. ( 25138170 )
2014
44
Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study. ( 24618148 )
2014
45
Surgeon as Educator: Bedside Ultrasound in Hypertrophic Pyloric Stenosis. ( 24931414 )
2014
46
Infantile hypertrophic pyloric stenosis in an extremely preterm male twin; a case report and review. ( 25197202 )
2014
47
Maternal and pregnancy characteristics and risk of infantile hypertrophic pyloric stenosis. ( 25092081 )
2014
48
The clinical features of infantile hypertrophic pyloric stenosis in Chinese Han population: analysis from 1998 to 2010. ( 24586444 )
2014
49
Role of ultrasonography in early diagnosis of infantile hypertrophic pyloric stenosis. ( 25671936 )
2014
50
Hypertrophic pyloric stenosis in twins; genetic or environmental factors. ( 24724922 )
2014

Variations for Hypertrophic Pyloric Stenosis

Expression for Hypertrophic Pyloric Stenosis

Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for Hypertrophic Pyloric Stenosis

Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.43 NOS1 NTRK3 RET TRPC6
2 10.55 TRPC5 TRPC6
3 10.23 DMD NOS1

GO Terms for Hypertrophic Pyloric Stenosis

Cellular components related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.92 DMD NOS1 RET TRPC5

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.78 MBNL1 NTRK3 RET TRPC5
2 neuron differentiation GO:0030182 9.58 RET TRPC5 TRPC6
3 cardiac muscle contraction GO:0060048 9.52 DMD NKX2-5
4 regulation of cytosolic calcium ion concentration GO:0051480 9.51 TRPC5 TRPC6
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.5 NTF4 NTRK3 RET
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.49 TRPC5 TRPC6
7 regulation of cardiac muscle contraction GO:0055117 9.46 NKX2-5 NOS1
8 innervation GO:0060384 9.43 NTF4 RET
9 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.37 DMD NOS1
10 manganese ion transport GO:0006828 9.26 TRPC5 TRPC6
11 negative regulation of dendrite morphogenesis GO:0050774 9.16 TRPC5 TRPC6
12 mechanoreceptor differentiation GO:0042490 8.96 NTF4 NTRK3
13 positive regulation of neuron differentiation GO:0045666 8.92 DMD NKX2-5 TRPC5 TRPC6

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 clathrin binding GO:0030276 9.26 TRPC5 TRPC6
2 store-operated calcium channel activity GO:0015279 9.16 TRPC5 TRPC6
3 actinin binding GO:0042805 8.96 TRPC5 TRPC6
4 inositol 1,4,5 trisphosphate binding GO:0070679 8.62 TRPC5 TRPC6

Sources for Hypertrophic Pyloric Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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