MCID: HYP009
MIFTS: 42

Hypertrophic Pyloric Stenosis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 10 12
Pyloric Stenosis, Hypertrophic 36 65
 
Congenital or Infantile Stricture of Pylorus 10
Congenital Hypertrophic Pyloric Stenosis 10

Classifications:



External Ids:

Disease Ontology10 DOID:12638
ICD1027 Q40.0
ICD9CM29 750.5
SNOMED-CT59 48644003
MeSH36 D046248
NCIt42 C98952
UMLS65 C0700639

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:10 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and acquired gastric outlet stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways are TRP channels and Cardiomyocyte Differentiation through BMP Receptors. Affiliated tissues include breast, lung and prostate, and related mouse phenotypes are respiratory system and behavior/neurological.

Related Diseases for Hypertrophic Pyloric Stenosis

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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1pyloric stenosis27.8GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
2acquired gastric outlet stenosis11.8
3esophagitis10.4
4ileitis10.3GDNF, NOS1
5esophageal atresia10.3
6pylorospasm10.3
7chronic orthostatic intolerance10.3IGF1, NOS1
8autoimmune gastrointestinal dysmotility10.2
9neuronitis10.2
10tracheoesophageal fistula10.2
11central hypoventilation syndrome, congenital10.2GDNF, RET
12parametritis10.2GDNF, RET
13pertussis10.2
14gilbert syndrome10.2
15focal epithelial hyperplasia10.1GDNF, RET
16shprintzen-goldberg syndrome10.1GDNF, RET
17multiple endocrine neoplasia iib10.1GDNF, RET
18heritable pulmonary arterial hypertension10.1GDNF, RET
19bacterial esophagitis10.1IGF1, RET
20hirschsprung disease 110.1GDNF, RET
21gastroenteritis10.1
22adenomyoma10.1
23congenital diaphragmatic hernia10.1
24eosinophilic gastroenteritis10.1
25pancreatitis10.1
26duodenitis10.1
27achalasia10.1
28anal spasm10.1GDNF, RET
29preretinal fibrosis10.0GDNF, RET
30myopathy with deficiency of iron-sulfur cluster assembly enzyme10.0GDNF, RET
31afferent loop syndrome10.0GDNF, RET
32transient arthritis9.9GDNF, NOS1, RET
33muscle hypertrophy9.9
34sudden infant death syndrome9.9
35cystic fibrosis9.9
36citrullinemia9.9
37phenylketonuria9.9
38gastroesophageal reflux9.9
39insulin-like growth factor i9.9
40androgen insensitivity9.9
41pulmonary hypertension9.9
42congenital hypothyroidism9.9
43hydronephrosis9.9
44heart disease9.9
45nephrocalcinosis9.9
46down syndrome9.9
47hypothyroidism9.9
48ventricular septal defect9.9
49congenital heart disease9.9
50intestinal perforation9.9

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric StenosisCompletedNCT00195949Phase 3
2The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in ChildhoodNot yet recruitingNCT01159509

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis


Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

33
Breast, Lung, Prostate, Liver, Bone, Thyroid, Spinal cord

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7HMOX2, IGF1, NKX2-5, NOS1, RET
2MP:00053867.9GDNF, HMOX2, MBNL1, NOS1, RET, TRPC5
3MP:00053847.3GDNF, IGF1, NKX2-5, NOS1, RET, TRPC5
4MP:00053697.3GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
5MP:00053857.3GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1
6MP:00036316.2GDNF, HMOX2, IGF1, MBNL1, NKX2-5, NOS1

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. (26944185)
2016
2
Adult idiopathic hypertrophic pyloric stenosis. (26154756)
2015
3
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
4
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
5
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
6
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
7
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
8
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
9
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
10
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
11
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
12
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
13
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
16
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
17
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
18
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
19
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
20
Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)
1999
21
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
22
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
23
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
24
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
25
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
26
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
27
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
28
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
29
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
30
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
31
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
32
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
33
Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. (3582407)
1987
34
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
35
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
36
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
37
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
38
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
39
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
40
The reliable sonographic diagnosis of hypertrophic pyloric stenosis. (6427283)
1984
41
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
42
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
43
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
44
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
45
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
46
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
47
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
48
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
49
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979
50

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1manganese ion transportGO:000682810.2TRPC5, TRPC6
2regulation of cardiac muscle contractionGO:005511710.2NKX2-5, NOS1
3response to nutrient levelsGO:003166710.1IGF1, NOS1
4regulation of cardiac conductionGO:19037799.9NKX2-5, NOS1
5response to heatGO:00094089.3IGF1, NOS1
6axon guidanceGO:00074119.2GDNF, TRPC5, TRPC6
7positive regulation of transcription, DNA-templatedGO:00458939.2IGF1, NKX2-5, NOS1, RET
8positive regulation of cell proliferationGO:00082849.1GDNF, IGF1, NKX2-5
9negative regulation of apoptotic processGO:00430668.9GDNF, IGF1, NKX2-5, NOS1
10positive regulation of transcription from RNA polymerase II promoterGO:00459448.6GDNF, IGF1, NKX2-5, NOS1

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inositol 1,4,5 trisphosphate bindingGO:00706799.7TRPC5, TRPC6

Sources for Hypertrophic Pyloric Stenosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet