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Hypertrophic Pyloric Stenosis malady

Gastrointestinal category
25 genes, 10 tissues, 89 related diseases, clinical trials.

Summaries for Hypertrophic Pyloric Stenosis

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MalaCards: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to hirschsprung's disease and achalasia. An important gene associated with Hypertrophic Pyloric Stenosis is HMOX2 (heme oxygenase (decycling) 2), and among its related pathways are Spinal Cord Injury and heme degradation. The compounds estrogen and kb-r7943 have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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8Disease Ontology, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal
ICD10: 25


Aliases & Descriptions:

hypertrophic pyloric stenosis 8
congenital hypertrophic pyloric stenosis 8
infantile stricture of pylorus 8
pyloric stenosis, hypertrophic 61


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Disease Ontology8 DOID:12638
ICD9CM27 750.5
SNOMED-CT57 48644003
MeSH35 D046248
ICD1025 Q40.0

Related Diseases for Hypertrophic Pyloric Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung's disease30.5GDNF
2achalasia30.5GAST, BLVRB, NOS1
3gastric outlet obstruction30.3MLN, GAST
4cystic fibrosis30.3ELN, NGFR
5pyloric stenosis, infantile hypertrophic 110.8
6pylorospasm10.6
7esophageal atresia10.5
8pyloric stenosis, infantile hypertrophic, 210.5
9gilbert syndrome10.4
10acquired gastric outlet stenosis10.4
11tracheoesophageal fistula10.4
12eosinophilic gastroenteritis10.4
13congenital diaphragmatic hernia10.4
14esophageal atresia/tracheoesophageal fistula10.4
15vacterl association10.2
16cutis laxa10.2
17gastric dilatation10.2
18congenital hypothyroidism10.2
19hydronephrosis10.2
20sudden infant death syndrome10.2
21dyspepsia10.2
22phenylketonuria10.2
23polyhydramnios10.2
24polycystic kidney disease10.2
25nephrocalcinosis10.2
26ventricular septal defect10.2
27corpus callosum agenesis10.2
28jejunal atresia10.2
29glaucoma, congenital10.2
30mesoblastic nephroma10.2
31penile agenesis10.2
32constipation10.0MLN
33impotence10.0NOS1
34malignant glioma10.0NGFR
35dementia10.0NOS1
36neuroblastoma10.0NGFR
37esophagitis10.0GAST
38neuroma10.0GDNF
39meningitis10.0GDNF
40meningioma10.0S100B
41pituitary adenoma10.0GDNF
42glomus tumor10.0DES
43fibrous meningioma10.0S100B
44cholelithiasis10.0UGT1A1
45lymphangioleiomyomatosis10.0DES
46gastroparesis10.0MLN, GAST
47allergic rhinitis10.0NGFR
48autonomic neuropathy10.0MLN, GAST
49hypoglycemia10.0MLN, GAST
50paraganglioma10.0GAST, S100B

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Clinical Features for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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33MalaCards
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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

33
Liver, Kidney, Lung, Heart, Smooth muscle, Small intestine, Pancreas, Breast, T cells, Endothelial

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
muscle phenotype
MP:00053698.7ELN, MBNL1, DES, NKX2-5, TRPC6, NGFR
2
cardiovascular system phenotype
MP:00053858.3DES, NKX2-5, TRPC1, TRPC6, NGFR, GDNF
3
homeostasis/metabolism phenotype
MP:00053768.2DES, NKX2-5, TRPC5, TYMP, NGFR, SIK3
4
behavior/neurological phenotype
MP:00053868.1S100B, DES, TRPC1, TRPC5, TRPC6, NGFR

Publications for Hypertrophic Pyloric Stenosis

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51PubMed
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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Peristaltic waves in infantile hypertrophic pyloric stenosis. (24112865)
2014
2
Evaluation of hypertrophic pyloric stenosis by pediatric emergency physician sonography. (23781883)
2013
3
The Question of an Infectious Etiology or Contribution to the Pathogenesis of Infantile Hypertrophic Pyloric Stenosis. (24345839)
2013
4
Prolonged prostaglandin E1 therapy in a neonate with pulmonary atresia and ventricular septal defect and the development of antral foveolar hyperplasia and hypertrophic pyloric stenosis. (23521358)
2013
5
Hypertrophic pyloric stenosis in premature infants: evaluation of sonographic criteria and short-term outcomes. (23686443)
2013
6
RET genomic variants in infantile hypertrophic pyloric stenosis. (22517526)
2012
7
Spectral changes in electrical activity of pylorus due to L-NAME induced hypertrophic pyloric stenosis. (21452773)
2011
8
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
9
High-resolution EUS to differentiate hypertrophic pyloric stenosis. (18028921)
2008
10
Is open or laparoscopic pyloromyotomy better for hypertrophic pyloric stenosis? (17325722)
2007
11
Prenatal prescription of macrolide antibiotics and infantile hypertrophic pyloric stenosis. (12681897)
2003
12
Esophageal achalasia and hypertrophic pyloric stenosis associated with a phytobezoar in an adolescent. (12194136)
2002
13
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
14
Re: "Glial derived growth factor signaling pathway in infantile hypertrophic pyloric stenosis (IHPS)". (11528629)
2001
15
Mandibular frenulum as a sign of infantile hypertrophic pyloric stenosis. (11241062)
2001
16
Ultrasonographic diagnosis criteria using scoring for hypertrophic pyloric stenosis. (11101721)
2000
17
Hunterian Lecture. The ontogeny of the peptide innervation of the human pylorus with special reference to understanding the aetiology and pathogenesis of infantile hypertrophic pyloric stenosis. (11103151)
2000
18
A rare coexistence of two gastric outlet obstructive lesions: infantile hypertrophic pyloric stenosis and organoaxial gastric volvulus. (10731880)
2000
19
From the Centers for Disease Control and Prevention. Hypertrophic pyloric stenosis in infants following pertussis prophylaxis with erythromycin--Knoxville, Tennessee, 1999. (10659863)
2000
20
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
21
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
22
Infantile hypertrophic pyloric stenosis presenting as pseudo-Bartter's syndrome and seizures: report of one case. (9684526)
1998
23
Active collagen synthesis in infantile hypertrophic pyloric stenosis. (9553179)
1998
24
Neuronal nitric oxide synthase, nNOS, is not linked to infantile hypertrophic pyloric stenosis in three families. (9660065)
1998
25
Congenital hypertrophic pyloric stenosis with associated polyhydramnios in a premature infant. (9241512)
1997
26
Evolution in the recognition of infantile hypertrophic pyloric stenosis. (9233980)
1997
27
Combined hypertrophic pyloric stenosis and duodenal web in Down syndrome: sonographic and radiographic diagnosis. (8738993)
1996
28
Infantile hypertrophic pyloric stenosis after surgery for esophageal atresia with tracheoesophageal fistula. (8870438)
1996
29
Infantile hypertrophic pyloric stenosis. (1521347)
1992
30
Infantile hypertrophic pyloric stenosis in a Third-World environment. (1519137)
1992
31
Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis. (1378938)
1992
32
Hyperplastic polyp of the stomach simulating hypertrophic pyloric stenosis. (1941416)
1991
33
Hypertrophic pyloric stenosis: use of the pyloric volume measurement in early US diagnosis. (2672088)
1989
34
Gastric emptying in adults treated for infantile hypertrophic pyloric stenosis. (2596255)
1989
35
Ultrasound in diagnosis of infantile hypertrophic pyloric stenosis. (2899696)
1988
36
Hypertrophic pyloric stenosis presenting in childhood. (3447123)
1987
37
Peptidergic innervation in infantile hypertrophic pyloric stenosis. (2422340)
1986
38
Influence of age, sex, duration of symptoms and dehydration of serum electrolytes in hypertrophic pyloric stenosis. (3094488)
1986
39
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
40
Observations and perspectives of the pathology and possible aetiology of infantile hypertrophic pyloric stenosis--a histological, biochemical, histochemical and immunocytochemical study. (2416261)
1985
41
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
42
Ultrasound diagnosis of hypertrophic pyloric stenosis. (6848725)
1983
43
Ultrasonography in diagnosis of hypertrophic pyloric stenosis. (6886923)
1983
44
Ultrasound diagnosis of hypertrophic pyloric stenosis: real-time application and the demonstration of a new sonographic sign. (6836129)
1983
45
Congenital hypertrophic pyloric stenosis: a long-term follow-up of 41 cases. (7425431)
1980
46
Serum gastrin levels in hypertrophic pyloric stenosis of infancy. Response to a gastrin secretion test. (434907)
1979
47
Fasting and postprandial serum gastrin levels in infants with congenital hypertrophic pyloric stenosis. (718286)
1978
48
Gastric emphysema in infants with hypertrophic pyloric stenosis. (98983)
1978
49
Association of antral diaphragms and hypertrophic pyloric stenosis. (97994)
1978
50
The value of the double-track sign as a differentiating factor between pylorospasm and hypertrophic pyloric stenosis in infants. (5934325)
1966

Genetic Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrophic Pyloric Stenosis

Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Spinal Cord Injury38
9.9NOS1, GDNF, NGFR
2
heme degradation38
Hide members
9.8HMOX2, BLVRB, UGT1A1
3
Heme Biosynthesis38
Hide members
9.8HMOX2, BLVRB, UGT1A1
4
Calcium channels12
9.7TRPC6, TRPC5, TRPC1
5
Netrin-1 signaling54
9.7TRPC1, TRPC5, TRPC6
6
Role of second messengers in netrin-1 signaling54
9.7TRPC1, TRPC5, TRPC6
7
Axon guidance54
Hide members
9.5TRPC1, TRPC5, TRPC6, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

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45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7ELN
2kb-r79432910.3TRPC5, TRPC6
3orcein4510.3S100B, DES, ELN
4gv 1500134510.2GAST, NOS1
5gsmtx-42910.1TRPC6, TRPC5, TRPC1
6skf963652910.1TRPC1, TRPC5, TRPC6
7gd3+2910.1TRPC1, TRPC5, TRPC6
82-aminoethoxydiphenylborane4510.1TRPC6, TRPC5
9la3+2910.0TRPC6, TRPC5, TRPC1
10trimebutine4510.0GAST, MLN
112-apb29 6011.0TRPC1, TRPC5, TRPC6
12ng-nitro-l-arginine4510.0NOS1, BLVRB, GAST
13hematoxylin4510.0S100B, DES, BLVRB, ELN
14catecholamine459.9S100B, BLVRB, NGFR, GDNF
15sodium nitroprusside459.9S100B, BLVRB, NOS1, ELN
16choline45 11 2411.8S100B, BLVRB, NGFR, GDNF, NOS1
17cgmp45 2910.7ELN, NOS1, HMOX2, BLVRB
18ethanol45 50 11 2412.7GDNF, NGFR, BLVRB, DES, S100B
19bromodeoxyuridine459.7S100B, GAST, DES, GDNF
20indomethacin45 60 29 1112.6UGT1A1, BLVRB, TYMP, NGFR, NOS1, ELN
21norepinephrine45 11 2411.6S100B, GAST, DES, GDNF, NOS1
22nicotine45 50 29 1112.6NOS1, NGFR, UGT1A1, GAST
23formaldehyde45 2410.6S100B, DES, BLVRB, TYMP, NOS1, ELN
24actinomycin d459.5DES, TYMP, GDNF, HMOX2, ELN
25gaba459.5S100B, GAST, BLVRB, NGFR, GDNF, NOS1
26carbon459.5BLVRB, HMOX2, NOS1, ELN
27paraffin459.5S100B, DES, BLVRB, TYMP, NGFR, ELN
28histamine45 29 2411.5GAST, MLN, NGFR, NOS1, ELN
29thymidine45 2410.5S100B, GAST, UGT1A1, DES, TYMP, NGFR
30glucose459.5GAST, MLN, TYMP, NGFR, GDNF, HMOX2
31retinoic acid45 2410.4S100B, UGT1A1, DES, NGFR, GDNF, NOS1
32dexamethasone45 50 29 1112.3S100B, GAST, UGT1A1, NGFR, GDNF, NOS1
33creatinine459.3S100B, GAST, DES, TYMP, GDNF, NOS1
34heparin45 29 11 2412.3S100B, GAST, MLN, DES, GDNF, ELN
35cysteine459.3S100B, DES, TYMP, NGFR, GDNF, NOS1
36oxygen45 2410.2S100B, DES, BLVRB, TYMP, NGFR, GDNF
37testosterone45 60 11 2412.2S100B, GAST, UGT1A1, DES, BLVRB, NOS1
38alanine459.2S100B, GAST, UGT1A1, MLN, GDNF, NOS1
39vegf459.2S100B, GAST, DES, TYMP, NGFR, GDNF
40genistein45 29 60 2 11 2414.2UGT1A1, TRPC5, GDNF, NOS1, ELN
41arginine459.1S100B, UGT1A1, MLN, DES, BLVRB, HMOX2
42adenylate459.1S100B, GAST, MLN, DES, BLVRB, GDNF
43glutamate459.1S100B, GAST, BLVRB, NGFR, GDNF, HMOX2
44dopamine45 29 11 2412.1S100B, GAST, MLN, BLVRB, NGFR, GDNF
45progesterone45 60 29 11 2412.9S100B, UGT1A1, MLN, DES, TRPC5, BLVRB
46acetylcholine45 50 29 11 2412.8NOS1, S100B, GAST, MLN, DES, BLVRB
47serine458.7S100B, GAST, MLN, DES, NKX2-5, TYMP
48tyrosine458.6S100B, GAST, UGT1A1, MLN, DES, BLVRB
49nitric oxide45 11 2410.4S100B, MLN, DES, NKX2-5, TRPC1, BLVRB
50calcium45 50 11 2410.8TRPC1, DES, MLN, GAST, S100B, TRPC5

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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16Gene Ontology
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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:05511710.1NOS1, NKX2-5
2heme catabolic processGO:0421679.8HMOX2, BLVRB, UGT1A1
3porphyrin-containing compound metabolic processGO:0067789.7HMOX2, BLVRB, UGT1A1
4axon guidanceGO:0074119.0TRPC1, TRPC5, TRPC6, NGFR, GDNF

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol 1,4,5 trisphosphate bindingGO:0706799.6TRPC6, TRPC5, TRPC1
2store-operated calcium channel activityGO:0152799.4TRPC6, TRPC5, TRPC1
3protein bindingGO:0055157.1NKX2-5, DES, GAST, MBNL1, S100B, TRPC1

Products for genes affiliated with Hypertrophic Pyloric Stenosis

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Sources for Hypertrophic Pyloric Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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