MCID: HYP009
MIFTS: 40

Hypertrophic Pyloric Stenosis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 11 13
Pyloric Stenosis, Hypertrophic 37 66
 
Congenital or Infantile Stricture of Pylorus 11
Congenital Hypertrophic Pyloric Stenosis 11

Classifications:



External Ids:

Disease Ontology11 DOID:12638
ICD1028 Q40.0
ICD9CM30 750.5
SNOMED-CT60 48644003
MeSH37 D046248
NCIt43 C98952

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:11 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and acquired gastric outlet stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways are TRP channels and Muscular Dystrophies and Dystrophin-Glycoprotein Complex. Affiliated tissues include pancreas, breast and smooth muscle, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Hypertrophic Pyloric Stenosis

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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1pyloric stenosis11.8
2acquired gastric outlet stenosis11.8
3esophagitis10.4
4esophageal atresia10.3
5pylorospasm10.3
6autoimmune gastrointestinal dysmotility10.2
7neuronitis10.2
8tracheoesophageal fistula10.2
9liver leiomyoma10.2NOS1, RET
10pertussis10.2
11gilbert syndrome10.2
12heart disease10.1
13congenital heart disease10.1
14gastroenteritis10.1
15adenomyoma10.1
16congenital diaphragmatic hernia10.1
17eosinophilic gastroenteritis10.1
18pancreatitis10.1
19duodenitis10.1
20achalasia10.1
21muscle hypertrophy9.9
22sudden infant death syndrome9.9
23cystic fibrosis9.9
24osteoglophonic dysplasia9.9
25citrullinemia9.9
26phenylketonuria9.9
27gastroesophageal reflux9.9
28insulin-like growth factor i9.9
29androgen insensitivity9.9
30jejunal atresia9.9
31pulmonary hypertension9.9
32congenital hypothyroidism9.9
33hydronephrosis9.9
34nephrocalcinosis9.9
35down syndrome9.9
36hypothyroidism9.9
37ventricular septal defect9.9
38intestinal perforation9.9
39dyspepsia9.9
40epidermolysis bullosa9.9
41cutis laxa9.9
42gastric dilatation9.9
43gastritis9.9
44eosinophilic gastritis9.9
45congenital mesoblastic nephroma9.9
46kidney disease9.9
47conjunctivitis9.9
48polyhydramnios9.9
49gastroduodenitis9.9
50neuropathy9.9

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric StenosisCompletedNCT00195949Phase 3
2The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in ChildhoodNot yet recruitingNCT01159509
3Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal AnesthesiaNot yet recruitingNCT02879292

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis


Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

34
Pancreas, Breast, Smooth muscle, Heart, Testes, Endothelial, Cervix

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

39 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4DMD, HMOX2, NOS1, RET, SST
2MP:00053698.0DMD, HMOX2, MBNL1, NKX2-5, NOS1, RET
3MP:00053887.9DMD, HMOX2, NKX2-5, NOS1, NTRK3, RET
4MP:00028737.6DMD, NKX2-5, NOS1, NTRK3, RET, SST
5MP:00030127.5DMD, NKX2-5, NOS1, NTRK3, RET, SST
6MP:00053767.0DMD, HMOX2, NKX2-5, NOS1, NTF4, RET
7MP:00053856.9DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTRK3
8MP:00053786.6DMD, MBNL1, NKX2-5, NOS1, NTF4, NTRK3
9MP:00107686.4DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4
10MP:00036315.6DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4
11MP:00053865.5DMD, HMOX2, MBNL1, NOS1, NTF4, NTRK3

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. (27292596)
2016
2
Ultrasound-guided paravertebral block for pyloromyotomy in 3 neonates with congenital hypertrophic pyloric stenosis. (26123148)
2015
3
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
4
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
5
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
6
Is hypertrophic pyloric stenosis a secondary disease? (23519860)
2013
7
Citrullinemia type I and hypertrophic pyloric stenosis in a 1-month old male infant. (24765495)
2013
8
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
9
Hypertrophic pyloric stenosis in the Third World. (21914675)
2011
10
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
11
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
12
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
13
Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a prospective, randomized controlled trial. (17448768)
2007
14
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
15
Hypertrophic pyloric stenosis in twins: same genes or same environments? (15965695)
2005
16
The role of UGT1A1*28 mutation in jaundiced infants with hypertrophic pyloric stenosis. (16257926)
2005
17
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
18
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
19
Intravenous atropine treatment in infantile hypertrophic pyloric stenosis. (12089130)
2002
20
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
21
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
22
Antenatal prediction of hypertrophic pyloric stenosis. (11666061)
2001
23
Ultrasonographic diagnosis criteria using scoring for hypertrophic pyloric stenosis. (11101721)
2000
24
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
25
Infantile hypertrophic pyloric stenosis: delays in diagnosis and overutilization of imaging modalities. (9915537)
1999
26
Jaundice with hypertrophic pyloric stenosis as an early manifestation of Gilbert syndrome. (10490432)
1999
27
Infantile hypertrophic pyloric stenosis presenting as pseudo-Bartter's syndrome and seizures: report of one case. (9684526)
1998
28
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
29
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
30
Ultrasound compared with clinical examination in infantile hypertrophic pyloric stenosis. (8984923)
1996
31
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
32
Hypertrophic pyloric stenosis in the neonate--diagnostic criteria revisited. (8425150)
1993
33
Sonography of hypertrophic pyloric stenosis: frequency and cause of nonuniform echogenicity of the thickened pyloric muscle. (1727338)
1992
34
Infantile hypertrophic pyloric stenosis. (1521347)
1992
35
Hyperplastic polyp of the stomach simulating hypertrophic pyloric stenosis. (1941416)
1991
36
Comparison of postpyloromyotomy feeding regimens in infantile hypertrophic pyloric stenosis. (1920229)
1991
37
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
38
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
39
Incidence of infantile hypertrophic pyloric stenosis in Saskatchewan, 1970-85. (2914260)
1989
40
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
41
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
42
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
43
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
44
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
45
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
46
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
47
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
48
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
49
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
50
Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis. (710968)
1978

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8TRPC5, TRPC6
29.6DMD, NOS1
3
Show member pathways
8.8NKX2-5, NTF4, NTRK3
48.6NOS1, NTRK3, RET, TRPC6

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Cellular components related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451218.8DMD, NOS1, RET, TRPC5

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:005511710.4NKX2-5, NOS1
2negative regulation of dendrite morphogenesisGO:005077410.3TRPC5, TRPC6
3manganese ion transportGO:000682810.3TRPC5, TRPC6
4positive regulation of peptidyl-threonine phosphorylationGO:001080010.2TRPC5, TRPC6
5regulation of cytosolic calcium ion concentrationGO:005148010.2TRPC5, TRPC6
6innervationGO:006038410.0NTF4, RET
7cardiac muscle contractionGO:00600489.8DMD, NKX2-5
8regulation of ryanodine-sensitive calcium-release channel activityGO:00603149.8DMD, NOS1
9mechanoreceptor differentiationGO:00424909.8NTF4, NTRK3
10neuron differentiationGO:00301829.4RET, TRPC5, TRPC6
11agingGO:00075689.4DMD, NOS1, TRPC6
12positive regulation of neuron differentiationGO:00456668.9DMD, NKX2-5, TRPC5, TRPC6
13transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071698.4NTF4, NTRK3, RET

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:001527910.0TRPC5, TRPC6
2actinin bindingGO:00428059.8TRPC5, TRPC6
3inositol 1,4,5 trisphosphate bindingGO:00706799.8TRPC5, TRPC6
4clathrin bindingGO:00302769.8TRPC5, TRPC6

Sources for Hypertrophic Pyloric Stenosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet