MCID: HYP009
MIFTS: 50

Hypertrophic Pyloric Stenosis malady

Gastrointestinal diseases category

Summaries for Hypertrophic Pyloric Stenosis

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MalaCards: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to pyloric stenosis and esophagitis. An important gene associated with Hypertrophic Pyloric Stenosis is HMOX2 (heme oxygenase (decycling) 2), and among its related pathways are Spinal Cord Injury and heme degradation. The compounds estrogen and orcein have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, breast and heart, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

hypertrophic pyloric stenosis 8
congenital hypertrophic pyloric stenosis 8
infantile stricture of pylorus 8
pyloric stenosis, hypertrophic 60


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Disease Ontology8 DOID:12638
ICD9CM27 750.5
SNOMED-CT56 48644003
MeSH34 D046248
ICD1025 Q40.0

Related Diseases for Hypertrophic Pyloric Stenosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Clinical Features for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

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Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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32MalaCards
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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

32
Smooth muscle, Breast, Heart, Kidney, Liver, Lung, Pancreas, Testes, Endothelial

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7ELN, MBNL1, DES, NKX2-5, TRPC6, NGFR
2MP:00053858.3DES, NKX2-5, TRPC1, TRPC6, NGFR, GDNF
3MP:00053768.2DES, NKX2-5, TRPC5, TYMP, NGFR, SIK3
4MP:00053868.1S100B, DES, TRPC1, TRPC5, TRPC6, NGFR

Publications for Hypertrophic Pyloric Stenosis

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50PubMed
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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
2
Infantile hypertrophic pyloric stenosis in twins. (23576655)
2013
3
A review of postoperative feeding regimens in infantile hypertrophic pyloric stenosis. (24094977)
2013
4
Is abandonment of nonoperative management of hypertrophic pyloric stenosis warranted? (23378159)
2013
5
Genome-wide linkage analysis in families with infantile hypertrophic pyloric stenosis indicates novel susceptibility loci. (22158425)
2012
6
The changing clinical presentation of hypertrophic pyloric stenosis: the experience of a large, tertiary care pediatric hospital. (21098534)
2011
7
Sonogram before and after pyloromyotomy: the pyloric ratio in infantile hypertrophic pyloric stenosis. (19579758)
2009
8
Infantile hypertrophic pyloric stenosis: genes and environment. (19028966)
2008
9
Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a prospective, randomized controlled trial. (17448768)
2007
10
Current management of hypertrophic pyloric stenosis. (17210480)
2007
11
Intravenous atropine treatment in hypertrophic pyloric stenosis: evaluation by clinical course and imaging. (17384478)
2007
12
Study of insulin-like growth factor-1 (IGF-1) and platelet-derived endothelial cell growth factor (PDEGF) expression in children with infantile hypertrophic pyloric stenosis. (16369467)
2006
13
Helicobacter pylori and infantile hypertrophic pyloric stenosis: is there a possible relationship? (16540793)
2006
14
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
15
The missing of missing mandibular frenulum in hypertrophic pyloric stenosis. (15625440)
2005
16
Changing trends in the management of infantile hypertrophic pyloric stenosis--an audit over 11 years. (16094910)
2005
17
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
18
New insights in infantile hypertrophic pyloric stenosis. (15055272)
2004
19
A histological study of the hph-1 mouse mutant: an animal model of phenylketonuria and infantile hypertrophic pyloric stenosis. (15144277)
2004
20
Treatment of infantile hypertrophic pyloric stenosis in a district general hospital: a review of 160 cases. (14523815)
2003
21
A novel point mutation of the androgen receptor (F804L) in an Egyptian newborn with complete androgen insensitivity associated with congenital glaucoma and hypertrophic pyloric stenosis. (12519373)
2003
22
Hypertrophic pyloric stenosis in infants: US evaluation of vascularity of the pyloric canal. (14526096)
2003
23
Hypertrophic pyloric stenosis in utero. (12415405)
2002
24
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
25
Sonography and color Doppler sonography for monitoring conservatively treated infantile hypertrophic pyloric stenosis. (11549161)
2001
26
Association of oesophageal atresia and hypertrophic pyloric stenosis. (10677071)
2000
27
Infantile hypertrophic pyloric stenosis. Decreasing incidence. (10913988)
2000
28
Infantile hypertrophic pyloric stenosis in a regional centre. (11006662)
2000
29
Increased local synthesis of epidermal growth factors in infantile hypertrophic pyloric stenosis. (10674347)
2000
30
Smooth muscle cell hypertrophy versus hyperplasia in infantile hypertrophic pyloric stenosis. (10367777)
1999
31
The development of hypertrophic pyloric stenosis in a patient with prostaglandin-induced foveolar hyperplasia. (10525782)
1999
32
Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress. (9553181)
1998
33
Adult hypertrophic pyloric stenosis: case report and review. (9771452)
1998
34
Medical management of hypertrophic pyloric stenosis. (9567568)
1997
35
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
36
The ontogeny of the peptide innervation of the human pylorus, with special reference to understanding the aetiology and pathogenesis of infantile hypertrophic pyloric stenosis. (8801298)
1996
37
Abnormal distribution of synaptic vesicle proteins in infantile hypertrophic pyloric stenosis. (8014779)
1994
38
Diagnosis of hypertrophic pyloric stenosis: value of sonography when used in conjunction with clinical findings and laboratory data. (8092033)
1994
39
Sonographic diagnosis of infantile hypertrophic pyloric stenosis. (1433467)
1992
40
Jaundice with hypertrophic pyloric stenosis. (2370609)
1990
41
Current management of infantile hypertrophic pyloric stenosis. (2189519)
1990
42
Incidence of infantile hypertrophic pyloric stenosis in Saskatchewan, 1970-85. (2914260)
1989
43
Changing patterns in the diagnosis of hypertrophic pyloric stenosis. (3277156)
1988
44
Recent results of treatment of infantile hypertrophic pyloric stenosis. (3178265)
1988
45
The spectrum of serum electrolytes in hypertrophic pyloric stenosis. (6620080)
1983
46
In pursuit of the etiology of congenital hypertrophic pyloric stenosis. (7186030)
1982
47
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
48
Congenital hypertrophic pyloric stenosis and associated anomalies in the genitourinary tract. (6279815)
1981
49
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979
50
Jejunal atresia with associated congenital hypertrophic pyloric stenosis. (13404778)
1956

Genetic Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS1, GDNF, NGFR
2
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9.8HMOX2, BLVRB, UGT1A1
3
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9.8HMOX2, BLVRB, UGT1A1
49.7TRPC6, TRPC5, TRPC1
59.7TRPC1, TRPC5, TRPC6
69.7TRPC1, TRPC5, TRPC6
7
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9.5TRPC1, TRPC5, TRPC6, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7ELN
2orcein4410.3ELN, DES, S100B
3kb-r79432810.3TRPC6, TRPC5
4gv 1500134410.2GAST, NOS1
5gsmtx-42810.1TRPC1, TRPC6, TRPC5
6skf963652810.1TRPC1, TRPC6, TRPC5
7gd3+2810.1TRPC1, TRPC5, TRPC6
82-aminoethoxydiphenylborane4410.1TRPC5, TRPC6
9la3+2810.0TRPC6, TRPC5, TRPC1
10trimebutine4410.0MLN, GAST
112-apb28 5911.0TRPC5, TRPC1, TRPC6
12ng-nitro-l-arginine4410.0GAST, NOS1, BLVRB
13hematoxylin4410.0ELN, BLVRB, DES, S100B
14catecholamine449.9S100B, BLVRB, NGFR, GDNF
15sodium nitroprusside449.9S100B, BLVRB, NOS1, ELN
16choline44 11 2411.8BLVRB, NGFR, NOS1, GDNF, S100B
17cgmp44 2810.7NOS1, BLVRB, HMOX2, ELN
18ethanol44 49 11 2412.7GDNF, NGFR, BLVRB, DES, S100B
19bromodeoxyuridine449.7DES, GDNF, S100B, GAST
20indomethacin44 59 28 1112.6UGT1A1, ELN, BLVRB, TYMP, NGFR, NOS1
21norepinephrine44 11 2411.6DES, NOS1, GDNF, S100B, GAST
22nicotine44 49 28 1112.6NOS1, GAST, UGT1A1, NGFR
23formaldehyde44 2410.6S100B, TYMP, BLVRB, NOS1, DES, ELN
24actinomycin d449.5HMOX2, GDNF, ELN, TYMP, DES
25gaba449.5S100B, GAST, NGFR, GDNF, NOS1, BLVRB
26carbon449.5NOS1, ELN, HMOX2, BLVRB
27paraffin449.5TYMP, ELN, NGFR, BLVRB, DES, S100B
28histamine44 28 2411.5ELN, NOS1, MLN, NGFR, GAST
29thymidine44 2410.5GAST, S100B, TYMP, NGFR, UGT1A1, DES
30glucose449.5HMOX2, GDNF, TYMP, MLN, GAST, NGFR
31retinoic acid44 2410.4UGT1A1, ELN, GDNF, NOS1, NGFR, S100B
32dexamethasone44 49 28 1112.3UGT1A1, S100B, GAST, NGFR, GDNF, NOS1
33creatinine449.3S100B, DES, GAST, GDNF, ELN, NOS1
34heparin44 28 11 2412.3ELN, DES, S100B, GAST, MLN, GDNF
35cysteine449.3ELN, DES, S100B, NOS1, GDNF, NGFR
36oxygen44 2410.2GDNF, NGFR, TYMP, BLVRB, DES, HMOX2
37testosterone44 59 11 2412.2UGT1A1, GAST, ELN, NOS1, S100B, BLVRB
38alanine449.2NOS1, MLN, S100B, UGT1A1, GAST, ELN
39vegf449.2NGFR, S100B, GAST, DES, TYMP, GDNF
40genistein44 28 59 2 11 2414.2NOS1, TRPC5, ELN, UGT1A1, GDNF
41arginine449.1UGT1A1, HMOX2, NOS1, MLN, S100B, ELN
42adenylate449.1GDNF, NOS1, BLVRB, DES, MLN, GAST
43glutamate449.1GDNF, HMOX2, NOS1, ELN, GAST, S100B
44dopamine44 28 11 2412.1NGFR, HMOX2, NOS1, S100B, BLVRB, GAST
45progesterone44 59 28 11 2412.9BLVRB, S100B, UGT1A1, MLN, HMOX2, NGFR
46acetylcholine44 49 28 11 2412.8GDNF, GAST, MLN, DES, BLVRB, NGFR
47serine448.7ELN, NOS1, GDNF, NGFR, TYMP, NKX2-5
48tyrosine448.6MLN, DES, TYMP, NGFR, GAST, S100B
49nitric oxide44 11 2410.4TRPC1, BLVRB, NKX2-5, DES, MLN, S100B
50calcium44 49 11 2410.8HMOX2, TRPC1, DES, MLN, GAST, S100B

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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16Gene Ontology
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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:05511710.1NOS1, NKX2-5
2heme catabolic processGO:0421679.8HMOX2, BLVRB, UGT1A1
3porphyrin-containing compound metabolic processGO:0067789.7HMOX2, BLVRB, UGT1A1
4axon guidanceGO:0074119.0TRPC1, TRPC5, TRPC6, NGFR, GDNF

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol 1,4,5 trisphosphate bindingGO:0706799.6TRPC6, TRPC5, TRPC1
2store-operated calcium channel activityGO:0152799.4TRPC6, TRPC5, TRPC1
3protein bindingGO:0055157.1NKX2-5, DES, GAST, MBNL1, S100B, TRPC1

Products for genes affiliated with Hypertrophic Pyloric Stenosis

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Sources for Hypertrophic Pyloric Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet