Hypertrophic Pyloric Stenosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology:¹¹ A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and acquired gastric outlet stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways are TRP channels and Muscular Dystrophies and Dystrophin-Glycoprotein Complex. Affiliated tissues include pancreas, smooth muscle and heart, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Hypertrophic Pyloric Stenosis

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3	Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5	Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

id	Related Disease	Score	Top Affiliating Genes
1	pyloric stenosis	12.0
2	acquired gastric outlet stenosis	11.7
3	esophagitis	10.3
4	esophageal atresia	10.2
5	pylorospasm	10.2
6	neuronitis	10.1
7	tracheoesophageal fistula	10.1
8	liver leiomyoma	10.1	NOS1, RET
9	proliferating trichilemmal cyst	10.1	DMD, NOS1
10	pertussis	10.0
11	gilbert syndrome	10.0
12	thrombocytopenia, x-linked	10.0	DMD, NOS1
13	lung large cell carcinoma	10.0	NTRK3, SST
14	heart disease	10.0
15	gastroenteritis	10.0
16	adenomyoma	10.0
17	congenital diaphragmatic hernia	10.0
18	eosinophilic gastroenteritis	10.0
19	pancreatitis	10.0
20	duodenitis	10.0
21	achalasia	10.0
22	adenosquamous cell lung carcinoma	9.9	NTRK3, SST
23	muscle hypertrophy	9.8
24	sudden infant death syndrome	9.8
25	cystic fibrosis	9.8
26	osteoglophonic dysplasia	9.8
27	citrullinemia	9.8
28	phenylketonuria	9.8
29	gastroesophageal reflux	9.8
30	insulin-like growth factor i	9.8
31	androgen insensitivity	9.8
32	jejunal atresia	9.8
33	pulmonary hypertension	9.8
34	congenital hypothyroidism	9.8
35	hydronephrosis	9.8
36	nephrocalcinosis	9.8
37	down syndrome	9.8
38	hypothyroidism	9.8
39	ventricular septal defect	9.8
40	intestinal perforation	9.8
41	dyspepsia	9.8
42	epidermolysis bullosa	9.8
43	cutis laxa	9.8
44	gastric dilatation	9.8
45	gastritis	9.8
46	eosinophilic gastritis	9.8
47	congenital mesoblastic nephroma	9.8
48	conjunctivitis	9.8
49	polyhydramnios	9.8
50	gastroduodenitis	9.8

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:

Symptoms & Phenotypes for Hypertrophic Pyloric Stenosis

Sources:
⁴¹MGI
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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

⁴¹ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.1	DMD, HMOX2, NOS1, RET, SST
2	muscle	MP:0005369	8.6	DMD, HMOX2, MBNL1, NKX2-5, NOS1, RET
3	normal	MP:0002873	8.4	DMD, NKX2-5, NOS1, NTRK3, RET, SST
4	no phenotypic analysis	MP:0003012	8.1	DMD, NKX2-5, NOS1, NTRK3, RET, SST
5	cardiovascular system	MP:0005385	7.9	DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTRK3
6	homeostasis/metabolism	MP:0005376	7.8	DMD, HMOX2, NKX2-5, NOS1, NTF4, RET
7	respiratory system	MP:0005388	7.7	DMD, HMOX2, NKX2-5, NOS1, NTRK3, RET
8	growth/size/body region	MP:0005378	7.6	DMD, MBNL1, NKX2-5, NOS1, NTF4, NTRK3
9	mortality/aging	MP:0010768	7.0	DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4
10	behavior/neurological	MP:0005386	6.7	DMD, HMOX2, MBNL1, NOS1, NTF4, NTRK3
11	nervous system	MP:0003631	6.3	DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4

Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Hypertrophic Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

id	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Central Nervous System Depressants			12806
2	Anesthetics			9001

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis	Completed	NCT00195949	Phase 3
2	The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood	Unknown status	NCT01159509
3	Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia	Not yet recruiting	NCT02879292

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

Anatomical Context for Hypertrophic Pyloric Stenosis

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

³⁶

Pancreas, Smooth muscle, Heart, Testes, Endothelial, Cervix, Liver

Publications for Hypertrophic Pyloric Stenosis

Sources:
⁵⁷PubMed
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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50) (show all 554)

id	Title	Authors	Year
1	Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. (27292596)	Mahida J.B.... Groner J.I.	2016
2	Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. (27669400)	Ednie A.C.... Yanchar N.	2016
3	Adult idiopathic hypertrophic pyloric stenosis. (27362602)	Richards S.... McCarthy G.	2016
4	Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. (26837724)	SA!nchez GarcA-a S.... GonzA!lez SA!nchez S.	2016
5	Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. (27599310)	Holder J.... Samin A.	2016
6	The cervix sign and other sonographic signs of hypertrophic pyloric stenosis. (27315074)	Indiran V.... Selvaraj V.	2016
7	Treating idiopathic hypertrophic pyloric stenosis with sequential therapy: A clinical study. (27439633)	Fan J.... Wang D.	2016
8	Successful combination of endoscopic pyloromyotomy and balloon dilatation for hypertrophic pyloric stenosis in an older child: A novel procedure. (27915443)	Yokoyama S.... Yamashita Y.	2016
9	Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease. (27528563)	Miyata S.... Bliss D.W.	2016
10	Ultrasound assessment of the gastric contents for the guidance of the anaesthetic strategy in infants with hypertrophic pyloric stenosis: a prospective cohort study. (27106968)	Gagey A.C.... Bouvet L.	2016
11	Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. (27642452)	Ogunlesi T.A.... Ogunfowora O.B.	2016
12	Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. (27215474)	Wu S.F.... Lin H.C.	2016
13	Asymmetric Hypertrophic Pyloric Stenosis with Concurrent Pancreatic Rest Presenting as Gastric Outlet Obstruction. (27179550)	Peng J.S.... Seifarth F.G.	2016
14	Health disparities in infants with hypertrophic pyloric stenosis. (27586849)	Feliz A.... Savoie K.B.	2016
15	A randomized trial to assess advancement of enteral feedings following surgery for hypertrophic pyloric stenosis. (27829521)	Markel T.A.... Ladd A.P.	2016
16	Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. (26944185)	Wayne C.... Nasr A.	2016
17	Is there any correlation between radiologic findings and eradication of symptoms after pyloromyotomy in hypertrophic pyloric stenosis? (27251656)	Badebarin D.... Zarrintan S.	2016
18	Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. (27506212)	Wolf L.L.... Buchmiller T.L.	2016
19	Optimizing fluid resuscitation in hypertrophic pyloric stenosis. (26876090)	Dalton B.G.... St Peter S.D.	2016
20	Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. (27655365)	Murchison L.... Eaton S.	2016
21	A novel missense mutation in the transcription factor FOXF1 co-segregating with infantile hypertrophic pyloric stenosis in the extended pedigree linked to IHPS5 on chromosome 16q24. (27855150)	Everett K.V.... Chung E.M.	2016
22	Recent changes in the features of hypertrophic pyloric stenosis. (26615824)	Bakal U.... Kazez A.	2016
23	Ultrasound-guided paravertebral block for pyloromyotomy in 3 neonates with congenital hypertrophic pyloric stenosis. (26123148)	Mata-GA^mez J.... Ontanilla A.	2015
24	Infantile hypertrophic pyloric stenosis at a tertiary care hospital in Tanzania: a surgical experience with 102 patients over a 5-year period. (26581339)	Chalya P.L.... Massenga A.	2015
25	Incidence and Concurrent Laparoscopic Repair of Hypertrophic Pyloric Stenosis and Patent Processus Vaginalis. (25836622)	Yan X.Q.... Bian H.Q.	2015
26	Spontaneous Intestinal Perforation and Infantile Hypertrophic Pyloric Stenosis in a Preterm Neonate: A Linked Etiopathogenesis? (26055488)	Chhina A.S.... Shenoi A.	2015
27	Maternal Factors in the Origin of Infantile Hypertrophic Pyloric Stenosis - a Population-based Case-control Study. (26394719)	Vermes G.... A8cs N.	2015
28	Brain oxygenation during laparoscopic correction of hypertrophic pyloric stenosis. (25768674)	Tytgat S.H.... van der Zee D.C.	2015
29	Adult idiopathic hypertrophic pyloric stenosis. (26154756)	Lin H.P.... Kuo C.Y.	2015
30	The use of ultrasonography in infantile hypertrophic pyloric stenosis: does the patient's age and weight affect pyloric size and pyloric ratio? (25745654)	Ayaz A.9.Y.... Api A.	2015
31	Birth outcomes of male and female patients with infantile hypertrophic pyloric stenosis - a population-based case-control study. (26135791)	Vermes G.... A8cs N.	2015
32	Association of prematurity with the development of infantile hypertrophic pyloric stenosis. (25950452)	Stark C.M.... Nylund C.M.	2015
33	Infantile Hypertrophic Pyloric Stenosis in Postoperative Esophageal Atresia with Tracheoesophageal Fistula. (26290814)	R A A H.... I R.	2015
34	Is There a Relation Between Pyloric Muscle Thickness and Clinical and Laboratory Data in Infants with Hypertrophic Pyloric Stenosis? (27011465)	Almaramhy H.H.	2015
35	Association between NKX2-5 rs29784 and infantile hypertrophic pyloric stenosis in Chinese Han population. (25932253)	Feng Z.... Zhang Y.	2015
36	Epidermolysis Bullosa with Hypertrophic Pyloric Stenosis in a Newborn. (26500857)	Ben Dhaou M.... Mhiri R.	2015
37	Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)	Dassinger M.... Fuchs G.J.	2014
38	How should the pyloric submucosal mass coexisting with hypertrophic pyloric stenosis be treated?: a case of pyloric ectopic pancreas with hypertrophic pyloric stenosis. (25349837)	Kim S.H.... Park K.W.	2014
39	Hypertrophic Pyloric Stenosis developing In a Patient Operated for Patent Urachus - A Case Report. (25057473)	Jangid M.K.... Taqi E.	2014
40	Maternal and pregnancy characteristics and risk of infantile hypertrophic pyloric stenosis. (25092081)	Svenningsson A.... NordenskjAPld A.	2014
41	Hypertrophic pyloric stenosis in infants: is it a congenital or acquired disorder? Reflections on 2 cases. (25332858)	Mouafo Tambo F.F.... Sosso M.A.	2014
42	Peristaltic waves in infantile hypertrophic pyloric stenosis. (24112865)	Lin C.Y.... Chiu N.C.	2014
43	Hypertrophic pyloric stenosis following repair of esophageal atresia and tracheo-esophageal fistula. (26023501)	Seguier-Lipszyc E.... Klin B.	2014
44	Balancing competing risks: perinatal exposure to macrolides increases the risk of infantile hypertrophic pyloric stenosis. (25121565)	Honein M.A.... Cragan J.D.	2014
45	Surgeon as Educator: Bedside Ultrasound in Hypertrophic Pyloric Stenosis. (24931414)	Wyrick D.L.... Dassinger M.S.	2014
46	Hyperplastic Gastric Polyps in an Infant, Mimicking Infantile Hypertrophic Pyloric Stenosis - A Case Report and Review of the Literature. (24814626)	Sithasanan N.... Ramanujam T.M.	2014
47	Hypertrophic pyloric stenosis in twins; genetic or environmental factors. (24724922)	Gezer H.O.... Hicsonmez A.	2014
48	Eosinophilic gastritis with gastric outlet obstruction mimicking infantile hypertrophic pyloric stenosis. (25222812)	Choi S.J.... Lee D.	2014
49	Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study. (24618148)	Lund M.... Melbye M.	2014
50	Environmental pesticides increase the risk of developing hypertrophic pyloric stenosis. (25783294)	Markel T.A.... Winchester P.D.	2014

Genes related to Hypertrophic Pyloric Stenosis

Sources:
¹³DISEASES, ²¹GeneCards
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Genes related to Hypertrophic Pyloric Stenosis:

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	NOS1	Nitric Oxide Synthase 1	24.38	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
2	NKX2-5	NK2 Homeobox 5	23.58	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
3	MBNL1	Muscleblind Like Splicing Regulator 1	23.21	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
4	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	23.11	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
5	TRPC5	Transient Receptor Potential Cation Channel Subfamily C Member 5	22.83	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
6	RET	Ret Proto-Oncogene	22.33	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
7	DMD	Dystrophin	22.23	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
8	SST	Somatostatin	22.22	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
9	NTF4	Neurotrophin 4	21.96	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
10	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	21.95	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
11	HMOX2	Heme Oxygenase 2	21.87	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)

Variations for Hypertrophic Pyloric Stenosis

Expression for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
³Cell Signaling Technology, ⁵⁵PathCards, ⁵⁸QIAGEN, ⁶⁰Reactome
See all MalaCards sources

Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	TRP channels⁶⁰	9.8	TRPC5, TRPC6
2	Muscular Dystrophies and Dystrophin-Glycoprotein Complex⁵⁸	9.7	DMD, NOS1
3	Human Embryonic Stem Cell Pluripotency⁵⁸ Show member pathways Factors Promoting Cardiogenesis in Vertebrates⁵⁸	8.7	NKX2-5, NTF4, NTRK3
4	Neuroscience³	8.6	NOS1, NTRK3, RET, TRPC6

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
¹⁹Gene Ontology
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Cellular components related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:0045121	9.0	DMD, NOS1, RET, TRPC5

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cardiac muscle contraction	GO:0055117	10.5	NKX2-5, NOS1
2	manganese ion transport	GO:0006828	10.4	TRPC5, TRPC6
3	negative regulation of dendrite morphogenesis	GO:0050774	10.4	TRPC5, TRPC6
4	cardiac muscle contraction	GO:0060048	10.4	DMD, NKX2-5
5	positive regulation of peptidyl-threonine phosphorylation	GO:0010800	10.3	TRPC5, TRPC6
6	regulation of cytosolic calcium ion concentration	GO:0051480	10.3	TRPC5, TRPC6
7	regulation of ryanodine-sensitive calcium-release channel activity	GO:0060314	10.3	DMD, NOS1
8	innervation	GO:0060384	10.1	NTF4, RET
9	aging	GO:0007568	10.0	DMD, NOS1, TRPC6
10	neuron differentiation	GO:0030182	10.0	RET, TRPC5, TRPC6
11	mechanoreceptor differentiation	GO:0042490	9.7	NTF4, NTRK3
12	positive regulation of neuron differentiation	GO:0045666	9.6	DMD, NKX2-5, TRPC5, TRPC6
13	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	8.6	NTF4, NTRK3, RET

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	actinin binding	GO:0042805	10.3	TRPC5, TRPC6
2	clathrin binding	GO:0030276	10.1	TRPC5, TRPC6
3	inositol 1,4,5 trisphosphate binding	GO:0070679	10.0	TRPC5, TRPC6
4	store-operated calcium channel activity	GO:0015279	9.8	TRPC5, TRPC6