MCID: HYP009
MIFTS: 41

Hypertrophic Pyloric Stenosis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Aliases & Descriptions for Hypertrophic Pyloric Stenosis:

Name: Hypertrophic Pyloric Stenosis 11 13
Pyloric Stenosis, Hypertrophic 38 67
 
Congenital or Infantile Stricture of Pylorus 11
Congenital Hypertrophic Pyloric Stenosis 11

Classifications:



External Ids:

Disease Ontology11 DOID:12638
ICD1029 Q40.0
ICD9CM31 750.5
SNOMED-CT61 48644003
MeSH38 D046248
NCIt44 C98952

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:11 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as pyloric stenosis, hypertrophic, is related to pyloric stenosis and acquired gastric outlet stenosis. An important gene associated with Hypertrophic Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways are TRP channels and Muscular Dystrophies and Dystrophin-Glycoprotein Complex. Affiliated tissues include pancreas, smooth muscle and heart, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Hypertrophic Pyloric Stenosis

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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1pyloric stenosis12.0
2acquired gastric outlet stenosis11.7
3esophagitis10.3
4esophageal atresia10.2
5pylorospasm10.2
6neuronitis10.1
7tracheoesophageal fistula10.1
8liver leiomyoma10.1NOS1, RET
9proliferating trichilemmal cyst10.1DMD, NOS1
10pertussis10.0
11gilbert syndrome10.0
12thrombocytopenia, x-linked10.0DMD, NOS1
13lung large cell carcinoma10.0NTRK3, SST
14heart disease10.0
15gastroenteritis10.0
16adenomyoma10.0
17congenital diaphragmatic hernia10.0
18eosinophilic gastroenteritis10.0
19pancreatitis10.0
20duodenitis10.0
21achalasia10.0
22adenosquamous cell lung carcinoma9.9NTRK3, SST
23muscle hypertrophy9.8
24sudden infant death syndrome9.8
25cystic fibrosis9.8
26osteoglophonic dysplasia9.8
27citrullinemia9.8
28phenylketonuria9.8
29gastroesophageal reflux9.8
30insulin-like growth factor i9.8
31androgen insensitivity9.8
32jejunal atresia9.8
33pulmonary hypertension9.8
34congenital hypothyroidism9.8
35hydronephrosis9.8
36nephrocalcinosis9.8
37down syndrome9.8
38hypothyroidism9.8
39ventricular septal defect9.8
40intestinal perforation9.8
41dyspepsia9.8
42epidermolysis bullosa9.8
43cutis laxa9.8
44gastric dilatation9.8
45gastritis9.8
46eosinophilic gastritis9.8
47congenital mesoblastic nephroma9.8
48conjunctivitis9.8
49polyhydramnios9.8
50gastroduodenitis9.8

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Drugs for Hypertrophic Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Central Nervous System Depressants12806
2Anesthetics9001

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric StenosisCompletedNCT00195949Phase 3
2The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in ChildhoodUnknown statusNCT01159509
3Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal AnesthesiaNot yet recruitingNCT02879292

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis


Cochrane evidence based reviews: pyloric stenosis, hypertrophic

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

35
Pancreas, Smooth muscle, Heart, Testes, Endothelial, Cervix, Liver

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

40 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1DMD, HMOX2, NOS1, RET, SST
2MP:00053698.6DMD, HMOX2, MBNL1, NKX2-5, NOS1, RET
3MP:00028738.4DMD, NKX2-5, NOS1, NTRK3, RET, SST
4MP:00030128.1DMD, NKX2-5, NOS1, NTRK3, RET, SST
5MP:00053857.9DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTRK3
6MP:00053767.8DMD, HMOX2, NKX2-5, NOS1, NTF4, RET
7MP:00053887.7DMD, HMOX2, NKX2-5, NOS1, NTRK3, RET
8MP:00053787.6DMD, MBNL1, NKX2-5, NOS1, NTF4, NTRK3
9MP:00107687.0DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4
10MP:00053866.7DMD, HMOX2, MBNL1, NOS1, NTF4, NTRK3
11MP:00036316.3DMD, HMOX2, MBNL1, NKX2-5, NOS1, NTF4

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. (27292596)
2016
2
Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. (27669400)
2016
3
Ultrasound-guided paravertebral block for pyloromyotomy in 3 neonates with congenital hypertrophic pyloric stenosis. (26123148)
2015
4
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
5
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
6
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
7
Is hypertrophic pyloric stenosis a secondary disease? (23519860)
2013
8
Citrullinemia type I and hypertrophic pyloric stenosis in a 1-month old male infant. (24765495)
2013
9
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
10
Hypertrophic pyloric stenosis in the Third World. (21914675)
2011
11
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
12
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
13
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
14
Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a prospective, randomized controlled trial. (17448768)
2007
15
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
16
Hypertrophic pyloric stenosis in twins: same genes or same environments? (15965695)
2005
17
The role of UGT1A1*28 mutation in jaundiced infants with hypertrophic pyloric stenosis. (16257926)
2005
18
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
19
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
20
Intravenous atropine treatment in infantile hypertrophic pyloric stenosis. (12089130)
2002
21
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
22
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
23
Antenatal prediction of hypertrophic pyloric stenosis. (11666061)
2001
24
Ultrasonographic diagnosis criteria using scoring for hypertrophic pyloric stenosis. (11101721)
2000
25
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
26
Infantile hypertrophic pyloric stenosis: delays in diagnosis and overutilization of imaging modalities. (9915537)
1999
27
Jaundice with hypertrophic pyloric stenosis as an early manifestation of Gilbert syndrome. (10490432)
1999
28
Infantile hypertrophic pyloric stenosis presenting as pseudo-Bartter's syndrome and seizures: report of one case. (9684526)
1998
29
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
30
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
31
Ultrasound compared with clinical examination in infantile hypertrophic pyloric stenosis. (8984923)
1996
32
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
33
Hypertrophic pyloric stenosis in the neonate--diagnostic criteria revisited. (8425150)
1993
34
Sonography of hypertrophic pyloric stenosis: frequency and cause of nonuniform echogenicity of the thickened pyloric muscle. (1727338)
1992
35
Infantile hypertrophic pyloric stenosis. (1521347)
1992
36
Hyperplastic polyp of the stomach simulating hypertrophic pyloric stenosis. (1941416)
1991
37
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
38
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
39
Incidence of infantile hypertrophic pyloric stenosis in Saskatchewan, 1970-85. (2914260)
1989
40
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
41
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
42
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
43
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
44
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
45
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
46
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
47
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
48
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
49
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
50
Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis. (710968)
1978

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8TRPC5, TRPC6
29.7DMD, NOS1
3
Show member pathways
8.7NKX2-5, NTF4, NTRK3
48.6NOS1, NTRK3, RET, TRPC6

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Cellular components related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451219.0DMD, NOS1, RET, TRPC5

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:005511710.4NKX2-5, NOS1
2negative regulation of dendrite morphogenesisGO:005077410.3TRPC5, TRPC6
3manganese ion transportGO:000682810.3TRPC5, TRPC6
4positive regulation of peptidyl-threonine phosphorylationGO:001080010.2TRPC5, TRPC6
5regulation of cytosolic calcium ion concentrationGO:005148010.2TRPC5, TRPC6
6innervationGO:00603849.9NTF4, RET
7regulation of ryanodine-sensitive calcium-release channel activityGO:00603149.9DMD, NOS1
8cardiac muscle contractionGO:00600489.8DMD, NKX2-5
9mechanoreceptor differentiationGO:00424909.7NTF4, NTRK3
10agingGO:00075689.3DMD, NOS1, TRPC6
11neuron differentiationGO:00301829.0RET, TRPC5, TRPC6
12positive regulation of neuron differentiationGO:00456669.0DMD, NKX2-5, TRPC5, TRPC6
13transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071698.8NTF4, NTRK3, RET

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:001527910.0TRPC5, TRPC6
2actinin bindingGO:00428059.8TRPC5, TRPC6
3inositol 1,4,5 trisphosphate bindingGO:00706799.8TRPC5, TRPC6
4clathrin bindingGO:00302769.8TRPC5, TRPC6

Sources for Hypertrophic Pyloric Stenosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet