Hypertrophic Pyloric Stenosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Hypertrophic Pyloric Stenosis

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MalaCards: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to pyloric stenosis and esophagitis. An important gene associated with Hypertrophic Pyloric Stenosis is HMOX2 (heme oxygenase (decycling) 2), and among its related pathways are Spinal Cord Injury and heme degradation. The compounds estrogen and kb-r7943 have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, breast and heart, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Hypertrophic Pyloric Stenosis

Sources:
⁸Disease Ontology, ⁶⁰UMLS, ²⁷ICD9CM, ⁵⁶SNOMED-CT, ³⁴MeSH, ²⁵ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases

ICD10: ²⁵

Congenital malformations, deformations and chromosomal abnormalities

Other congenital malformations of the digestive system

Other congenital malformations of upper alimentary tract

Congenital hypertrophic pyloric stenosis

Aliases & Descriptions:

hypertrophic pyloric stenosis ⁸

congenital hypertrophic pyloric stenosis ⁸

infantile stricture of pylorus ⁸

pyloric stenosis, hypertrophic ⁶⁰

External Ids:

Disease Ontology⁸ DOID:12638

ICD9CM²⁷ 750.5

SNOMED-CT⁵⁶ 48644003

MeSH³⁴ D046248

ICD10²⁵ Q40.0

UMLS⁶⁰ C0700639

Related Diseases for Hypertrophic Pyloric Stenosis

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¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 97)

id	Related Disease	Score	Top Affiliating Genes
1	pyloric stenosis	32.3	NOS1, BLVRB, GAST
2	esophagitis	30.8	GAST
3	achalasia	30.5	NOS1, GAST, BLVRB
4	hirschsprung's disease	30.3	GDNF
5	cystic fibrosis	30.2	NGFR, ELN
6	pylorospasm	10.5
7	neuronitis	10.5
8	esophageal atresia	10.5
9	acquired gastric outlet stenosis	10.5
10	gilbert syndrome	10.4
11	x-linked ichthyosis	10.4
12	pertussis	10.4
13	eosinophilic gastroenteritis	10.3
14	duodenitis	10.3
15	congenital diaphragmatic hernia	10.3
16	gastroenteritis	10.3
17	vacterl association	10.2
18	cutis laxa	10.2
19	gastric dilatation	10.2
20	congenital hypothyroidism	10.2
21	hydronephrosis	10.2
22	sudden infant death syndrome	10.2
23	dyspepsia	10.2
24	phenylketonuria	10.2
25	polyhydramnios	10.2
26	polycystic kidney disease	10.2
27	gastroduodenitis	10.2
28	nephrocalcinosis	10.2
29	down syndrome	10.2
30	congenital mesoblastic nephroma	10.2
31	conjunctivitis	10.2
32	esophageal disease	10.2
33	glaucoma	10.2
34	hypertension	10.2
35	hypothyroidism	10.2
36	kidney disease	10.2
37	neuropathy	10.2
38	pancreatitis	10.2
39	ventricular septal defect	10.2
40	esophageal atresia/tracheoesophageal fistula	10.2
41	constipation	10.0	MLN
42	impotence	10.0	NOS1
43	malignant glioma	10.0	NGFR
44	dementia	10.0	NOS1
45	neuroblastoma	10.0	NGFR
46	neuroma	10.0	GDNF
47	meningitis	10.0	GDNF
48	meningioma	10.0	S100B
49	pituitary adenoma	10.0	GDNF
50	glomus tumor	10.0	DES

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:

Clinical Features for Hypertrophic Pyloric Stenosis

Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypertrophic Pyloric Stenosis

Drug clinical trials:

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Genetic Tests for Hypertrophic Pyloric Stenosis

Anatomical Context for Hypertrophic Pyloric Stenosis

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³²MalaCards
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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

³²

Smooth muscle, Breast, Heart, Kidney, Liver, Lung, Pancreas, Testes, Endothelial

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	8.7	ELN, MBNL1, DES, NKX2-5, TRPC6, NGFR
2	cardiovascular system phenotype	MP:0005385	8.3	DES, NKX2-5, TRPC1, TRPC6, NGFR, GDNF
3	homeostasis/metabolism phenotype	MP:0005376	8.2	DES, NKX2-5, TRPC5, TYMP, NGFR, SIK3
4	behavior/neurological phenotype	MP:0005386	8.1	S100B, DES, TRPC1, TRPC5, TRPC6, NGFR

Publications for Hypertrophic Pyloric Stenosis

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⁵⁰PubMed
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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50) (show all 497)

id	Title	Authors	Year
1	Hypertrophic pyloric stenosis in a newborn: a diagnostic dilemma. (21636874)	Chan S.M.... Lee K.H.	2011
2	Infantile hypertrophic pyloric stenosis before 3 weeks of age in infants and preterm babies. (20557472)	Huang I.F.... Ruiz J.P.	2011
3	Idiopathic non-hypertrophic pyloric stenosis in an infant successfully treated via endoscopic approach. (21191516)	Karnsakul W.... Vaughan R.	2010
4	Malrotation associated with infantile hypertrophic pyloric stenosis in a neonate. (19208071)	Pandey A.... Upadhyay V.D.	2009
5	Rapid correction of metabolic alkalosis in hypertrophic pyloric stenosis with intravenous cimetidine: preliminary results. (19169692)	Banieghbal B.	2009
6	Feasibility of emergency physician diagnosis of hypertrophic pyloric stenosis using point-of-care ultrasound: a multi-center case series. (18572347)	Malcom G.E.... Tsung J.W.	2009
7	Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing. (19701773)	Everett K.V.... Chung E.M.	2009
8	Absence of motilin gene mutations in infantile hypertrophic pyloric stenosis. (18358279)	Svenningsson A.... NordenskjAPld A.	2008
9	Linkage of monogenic infantile hypertrophic pyloric stenosis to chromosome 16q24. (18478043)	Everett K.V.... Chung E.M.	2008
10	Hypertrophic pyloric stenosis in mono-ovular extremely preterm twins after use of erythromycin. (19261125)	Shoji H.... Yamashiro Y.	2008
11	Adenomyoma of the stomach mimicking infantile hypertrophic pyloric stenosis. (18022419)	Takeyama J.... Nio M.	2007
12	Choice of incision: the experience and evolution of surgical management of infantile hypertrophic pyloric stenosis. (17362191)	Aldridge R.D.... Aldridge R.B.	2007
13	Are young infants treated with erythromycin at risk for developing hypertrophic pyloric stenosis? (17337692)	Maheshwai N.	2007
14	Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: impact of experience on the results in 182 cases. (15108114)	van der Bilt J.D.... Bax N.M.	2004
15	Penile agenesis and congenital hypertrophic pyloric stenosis: an association or a random coexistence? (15368696)	Yagmurlu A.... Gokcora I.H.	2004
16	Muscle thickness in infants hypertrophic pyloric stenosis. (12916445)	Spinelli C.... Ughi C.	2003
17	Recessive X-linked ichthyosis associated with hypertrophic pyloric stenosis: a chance occurrence? (12558636)	Bruno L.... Magnelli N.	2003
18	Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)	Cooper W.O.... Ray W.A.	2002
19	Ultrasonographic follow-up of infantile hypertrophic pyloric stenosis after pyloromyotomy: a controlled prospective study. (12548489)	Tander B.... Bulut M.	2002
20	Ultrasound diagnosis of infantile hypertrophic pyloric stenosis: determinants of pyloric length and the effect of prematurity. (11977948)	Haider N.... Grier D.	2002
21	A possible role of the plasmalemmal cytoskeleton, nitric oxide synthase, and innervation in infantile hypertrophic pyloric stenosis. (10663874)	Sheth N.P.	2000
22	Should infantile hypertrophic pyloric stenosis be managed in specialist centres? (11006659)	Corbally M.T.	2000
23	Is Helicobacter pylori a cause of infantile hypertrophic pyloric stenosis? (10904427)	Paulozzi L.J.	2000
24	Infantile hypertrophic pyloric stenosis: delays in diagnosis and overutilization of imaging modalities. (9915537)	Abbas A.E.... Alvear D.T.	1999
25	An uncommon association of H-type tracheoesophageal fistula with infantile hypertrophic pyloric stenosis. (10770691)	OA9uzkurt P.... HiAssAPnmez A.	1999
26	Hypertrophic pyloric stenosis in infants following pertussis prophylaxis with erythromycin--Knoxville, Tennessee, 1999. (10634345)		1999
27	Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)	Ohshiro K.... Puri P.	1998
28	Coexisting hyperplastic antral polyp and hypertrophic pyloric stenosis. (9388280)	Kim S.... Specter B.B.	1997
29	Changing patterns of diagnosis and treatment of infantile hypertrophic pyloric stenosis: a clinical audit of 303 patients. (8986971)	Poon T.S.... Cass D.T.	1996
30	Lack of intestinal pacemaker (C-KIT-positive) cells in infantile hypertrophic pyloric stenosis. (8632295)	Yamataka A.... Miyano T.	1996
31	Medical treatment of idiopathic hypertrophic pyloric stenosis: should we marinate or slice the "olive"? (8956174)	Rudolph C.D.	1996
32	Breast feeding and hypertrophic pyloric stenosis: population based case-control study. (8605461)	Pisacane A.... Pinto L.	1996
33	Surgical technique of laparoscopic pyloromyotomy for infantile hypertrophic pyloric stenosis. (8520173)	Hamada Y.... Matsuda T.	1995
34	Early experience with laparoscopic pyloromyotomy for infantile hypertrophic pyloric stenosis. (7722825)	Najmaldin A.... Tan H.L.	1995
35	A new technique for laparoscopic repair of hypertrophic pyloric stenosis. (8523228)	CastaA+A^n J.... Ramos A.	1995
36	The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)	Mitchell L.E.... Risch N.	1993
37	Hypertrophic pyloric stenosis in the newborn. (8301497)	Zenn M.R.... Redo S.F.	1993
38	Renal abnormalities in children with hypertrophic pyloric stenosis--fact or fallacy? (8414755)	Fernbach S.K.... Morello F.P.	1993
39	Comparison of postpyloromyotomy feeding regimens in infantile hypertrophic pyloric stenosis. (1920229)	Turnock R.R.... Rangecroft L.	1991
40	Infantile hypertrophic pyloric stenosis in Dar Es Salaam. (1893403)	Carneiro P.M.	1991
41	Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)	Dieler R.... Steinau G.	1990
42	Ultrasonic "double track" sign in hypertrophic pyloric stenosis. (3550137)	Cohen H.L.... Haller J.O.	1987
43	Case study: congenital hypertrophic pyloric stenosis in twins. (3644130)	Wilson G.N.	1987
44	Re: Infantile hypertrophic pyloric stenosis. (3744758)	McNicholl B.	1986
45	Problems in diagnosis and treatment of infantile hypertrophic pyloric stenosis. (3982549)	Davis S.J.... Schultz L.R.	1985
46	Incidence of infantile hypertrophic pyloric stenosis. (6144893)	Grant G.A.... McAleer J.J.	1984
47	Infantile hypertrophic pyloric stenosis: surgical experience of 24 cases. (7344572)	Yip W.C.... Ho T.F.	1981
48	The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)	Wesley J.R.... Vinik A.I.	1980
49	Six atypical presentations of congenital hypertrophic pyloric stenosis. (761434)	Weinstein M.M.... Erenberg A.	1979
50	Hypertrophic pyloric stenosis following repair of congenital diaphragmatic hernia. (512805)	Redman M.... Ross D.A.	1979

Genes related to Hypertrophic Pyloric Stenosis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Hypertrophic Pyloric Stenosis:

(show all 25)

id	Symbol	Description	Score	Implication
1	HMOX2	heme oxygenase (decycling) 2	20.42	GeneCards inferred : Publications, Disorders (show sections)
2	NKX2-5	NK2 homeobox 5	19.62	GeneCards inferred : Publications, Disorders (show sections)
3	NOS1	nitric oxide synthase 1 (neuronal)	18.82	GeneCards inferred : Publications, Disorders (show sections)
4	NGFR	nerve growth factor receptor	18.02	GeneCards inferred : Publications, Disorders (show sections)
5	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	17.22	GeneCards inferred : Publications, Disorders (show sections)
6	TRPC6	transient receptor potential cation channel, subfamily C, member 6	16.42	GeneCards inferred : Publications, Disorders (show sections)
7	S100B	S100 calcium binding protein B	15.62	GeneCards inferred : Publications, Disorders (show sections)
8	GDNF	glial cell derived neurotrophic factor	14.82	GeneCards inferred : Publications, Disorders (show sections)
9	TYMP	thymidine phosphorylase	14.02	GeneCards inferred : Publications, Disorders (show sections)
10	DES	desmin	13.22	GeneCards inferred : Publications, Disorders (show sections)
11	ELN	elastin	12.42	GeneCards inferred : Publications, Disorders (show sections)
12	TRPC5	transient receptor potential cation channel, subfamily C, member 5	11.62	GeneCards inferred : Publications, Disorders (show sections)
13	MBNL1	muscleblind-like splicing regulator 1	10.82	GeneCards inferred : Publications, Disorders (show sections)
14	BNIP1	BCL2/adenovirus E1B 19kDa interacting protein 1	10.02	GeneCards inferred : Publications, Disorders (show sections)
15	MGC34034	uncharacterized protein MGC34034	9.22	GeneCards inferred : Publications, Disorders (show sections)
16	BLVRB	biliverdin reductase B (flavin reductase (NADPH))	8.42	GeneCards inferred : Publications, Disorders (show sections)
17	MLN	motilin	7.62	GeneCards inferred : Publications, Disorders (show sections)
18	GAST	gastrin	6.82	GeneCards inferred : Publications, Disorders (show sections)
19	TRPC1	transient receptor potential cation channel, subfamily C, member 1	6.02	GeneCards inferred : Publications, Disorders (show sections)
20	SIK3	SIK family kinase 3	5.22	GeneCards inferred : Publications, Disorders (show sections)
21	IGF1	insulin-like growth factor 1 (somatomedin C)	4.42	GeneCards inferred : Publications, Disorders (show sections)
22	TGFB1	transforming growth factor, beta 1	3.62	GeneCards inferred : Publications, Disorders (show sections)
23	SUCNR1	succinate receptor 1	2.47	GeneCards inferred : Publications (show sections)
24	C3orf79	chromosome 3 open reading frame 79	1.66	GeneCards inferred : Publications (show sections)
25	RET	ret proto-oncogene	0.81	GeneCards inferred : Publications (show sections)

Products for genes related to Hypertrophic Pyloric Stenosis disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	23	23	23
2	LSBio	-	-	25

Genetic Variations for Hypertrophic Pyloric Stenosis

Expression for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Hypertrophic Pyloric Stenosis

Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
³⁷NCBI BioSystems Database, ⁵³Reactome, ¹²EMD Millipore
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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Spinal Cord Injury³⁷	9.9	NOS1, GDNF, NGFR
2	heme degradation³⁷ Hide members Heme degradation⁵³	9.8	HMOX2, BLVRB, UGT1A1
3	Heme Biosynthesis³⁷ Hide members Metabolism of porphyrins⁵³	9.8	HMOX2, BLVRB, UGT1A1
4	Calcium channels¹²	9.7	TRPC6, TRPC5, TRPC1
5	Netrin-1 signaling⁵³	9.7	TRPC1, TRPC5, TRPC6
6	Role of second messengers in netrin-1 signaling⁵³	9.7	TRPC1, TRPC5, TRPC6
7	Axon guidance⁵³ Hide members Developmental Biology⁵³	9.5	TRPC1, TRPC5, TRPC6, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
⁴⁴Novoseek, ²⁸IUPHAR, ⁵⁹Tocris Bioscience, ¹¹DrugBank, ²⁴HMDB, ⁴⁹PharmGKB, ²BitterDB
See all sources

Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

(show top 50) (show all 77)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.7	ELN
2	kb-r7943²⁸	10.3	TRPC5, TRPC6
3	orcein⁴⁴	10.3	S100B, DES, ELN
4	gv 150013⁴⁴	10.2	GAST, NOS1
5	gsmtx-4²⁸	10.1	TRPC6, TRPC5, TRPC1
6	skf96365²⁸	10.1	TRPC1, TRPC5, TRPC6
7	gd³⁺²⁸	10.1	TRPC1, TRPC5, TRPC6
8	2-aminoethoxydiphenylborane⁴⁴	10.1	TRPC6, TRPC5
9	la³⁺²⁸	10.0	TRPC6, TRPC5, TRPC1
10	trimebutine⁴⁴	10.0	GAST, MLN
11	2-apb²⁸ ⁵⁹	11.0	TRPC1, TRPC5, TRPC6
12	ng-nitro-l-arginine⁴⁴	10.0	NOS1, BLVRB, GAST
13	hematoxylin⁴⁴	10.0	S100B, DES, BLVRB, ELN
14	catecholamine⁴⁴	9.9	S100B, BLVRB, NGFR, GDNF
15	sodium nitroprusside⁴⁴	9.9	S100B, BLVRB, NOS1, ELN
16	choline⁴⁴ ¹¹ ²⁴	11.8	S100B, BLVRB, NGFR, GDNF, NOS1
17	cgmp⁴⁴ ²⁸	10.7	ELN, NOS1, HMOX2, BLVRB
18	ethanol⁴⁴ ⁴⁹ ¹¹ ²⁴	12.7	GDNF, NGFR, BLVRB, DES, S100B
19	bromodeoxyuridine⁴⁴	9.7	S100B, GAST, DES, GDNF
20	indomethacin⁴⁴ ⁵⁹ ²⁸ ¹¹	12.6	UGT1A1, BLVRB, TYMP, NGFR, NOS1, ELN
21	norepinephrine⁴⁴ ¹¹ ²⁴	11.6	S100B, GAST, DES, GDNF, NOS1
22	nicotine⁴⁴ ⁴⁹ ²⁸ ¹¹	12.6	NOS1, NGFR, UGT1A1, GAST
23	formaldehyde⁴⁴ ²⁴	10.6	S100B, DES, BLVRB, TYMP, NOS1, ELN
24	actinomycin d⁴⁴	9.5	DES, TYMP, GDNF, HMOX2, ELN
25	gaba⁴⁴	9.5	S100B, GAST, BLVRB, NGFR, GDNF, NOS1
26	carbon⁴⁴	9.5	BLVRB, HMOX2, NOS1, ELN
27	paraffin⁴⁴	9.5	S100B, DES, BLVRB, TYMP, NGFR, ELN
28	histamine⁴⁴ ²⁸ ²⁴	11.5	GAST, MLN, NGFR, NOS1, ELN
29	thymidine⁴⁴ ²⁴	10.5	S100B, GAST, UGT1A1, DES, TYMP, NGFR
30	glucose⁴⁴	9.5	GAST, MLN, TYMP, NGFR, GDNF, HMOX2
31	retinoic acid⁴⁴ ²⁴	10.4	S100B, UGT1A1, DES, NGFR, GDNF, NOS1
32	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.3	S100B, GAST, UGT1A1, NGFR, GDNF, NOS1
33	creatinine⁴⁴	9.3	S100B, GAST, DES, TYMP, GDNF, NOS1
34	heparin⁴⁴ ²⁸ ¹¹ ²⁴	12.3	S100B, GAST, MLN, DES, GDNF, ELN
35	cysteine⁴⁴	9.3	S100B, DES, TYMP, NGFR, GDNF, NOS1
36	oxygen⁴⁴ ²⁴	10.2	S100B, DES, BLVRB, TYMP, NGFR, GDNF
37	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	12.2	S100B, GAST, UGT1A1, DES, BLVRB, NOS1
38	alanine⁴⁴	9.2	S100B, GAST, UGT1A1, MLN, GDNF, NOS1
39	vegf⁴⁴	9.2	S100B, GAST, DES, TYMP, NGFR, GDNF
40	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	14.2	UGT1A1, TRPC5, GDNF, NOS1, ELN
41	arginine⁴⁴	9.1	S100B, UGT1A1, MLN, DES, BLVRB, HMOX2
42	adenylate⁴⁴	9.1	S100B, GAST, MLN, DES, BLVRB, GDNF
43	glutamate⁴⁴	9.1	S100B, GAST, BLVRB, NGFR, GDNF, HMOX2
44	dopamine⁴⁴ ²⁸ ¹¹ ²⁴	12.1	S100B, GAST, MLN, BLVRB, NGFR, GDNF
45	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	12.9	S100B, UGT1A1, MLN, DES, TRPC5, BLVRB
46	acetylcholine⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	12.8	NOS1, S100B, GAST, MLN, DES, BLVRB
47	serine⁴⁴	8.7	S100B, GAST, MLN, DES, NKX2-5, TYMP
48	tyrosine⁴⁴	8.6	S100B, GAST, UGT1A1, MLN, DES, BLVRB
49	nitric oxide⁴⁴ ¹¹ ²⁴	10.4	S100B, MLN, DES, NKX2-5, TRPC1, BLVRB
50	calcium⁴⁴ ⁴⁹ ¹¹ ²⁴	10.8	TRPC1, DES, MLN, GAST, S100B, TRPC5

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cardiac muscle contraction	GO:055117	10.1	NOS1, NKX2-5
2	heme catabolic process	GO:042167	9.8	HMOX2, BLVRB, UGT1A1
3	porphyrin-containing compound metabolic process	GO:006778	9.7	HMOX2, BLVRB, UGT1A1
4	axon guidance	GO:007411	9.0	TRPC1, TRPC5, TRPC6, NGFR, GDNF

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	inositol 1,4,5 trisphosphate binding	GO:070679	9.6	TRPC6, TRPC5, TRPC1
2	store-operated calcium channel activity	GO:015279	9.4	TRPC6, TRPC5, TRPC1
3	protein binding	GO:005515	7.1	NKX2-5, DES, GAST, MBNL1, S100B, TRPC1

Products for genes affiliated with Hypertrophic Pyloric Stenosis

Antibodies
Proteins
Lysates

Antibodies

Sources for Hypertrophic Pyloric Stenosis

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

MCID: HYP009 MIFTS: 50	Hypertrophic Pyloric Stenosis malady Gastrointestinal diseases category
25 genes, 9 tissues, 97 related diseases, clinical trials.

Hypertrophic Pyloric Stenosis malady