MCID: HYP009
MIFTS: 43

Hypertrophic Pyloric Stenosis malady

Gastrointestinal diseases category

Summaries for Hypertrophic Pyloric Stenosis

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Disease Ontology:9 A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting.

MalaCards based summary: Hypertrophic Pyloric Stenosis, also known as congenital hypertrophic pyloric stenosis, is related to pyloric stenosis and esophagitis. An important gene associated with Hypertrophic Pyloric Stenosis is NKX2-5 (NK2 homeobox 5), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and imipramine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, pancreas and breast, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Hypertrophic Pyloric Stenosis

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Hypertrophic Pyloric Stenosis, Aliases & Descriptions:

Name: Hypertrophic Pyloric Stenosis 9
Congenital Hypertrophic Pyloric Stenosis 9
 
Infantile Stricture of Pylorus 9
Pyloric Stenosis, Hypertrophic 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:12638
MeSH33 D046248
SNOMED-CT55 48644003
ICD9CM27 750.5
ICD1025 Q40.0

Related Diseases for Hypertrophic Pyloric Stenosis

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Diseases in the Hypertrophic Pyloric Stenosis family:

Pyloric Stenosis, Infantile Hypertrophic, 3 Pyloric Stenosis, Infantile Hypertrophic, 2
Pyloric Stenosis, Infantile Hypertrophic, 5 Pyloric Stenosis, Infantile Hypertrophic, 4

Diseases related to Hypertrophic Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1pyloric stenosis33.0NOS1
2esophagitis10.6
3pylorospasm10.6
4acquired gastric outlet stenosis10.6
5neuronitis10.5
6esophageal atresia10.5
7gilbert syndrome10.5
8pertussis10.5
9tracheoesophageal fistula10.5
10gastric outlet obstruction10.5
11eosinophilic gastroenteritis10.4
12duodenitis10.4
13achalasia10.4
14congenital diaphragmatic hernia10.4
15gastroenteritis10.4
16neonatal jaundice10.4UGT1A1
17hirschsprung disease 110.3GDNF
18muscle hypertrophy10.2
19sudden infant death syndrome10.2
20cystic fibrosis10.2
21phenylketonuria10.2
22gastroesophageal reflux10.2
23insulin-like growth factor i10.2
24citrullinemia10.2
25androgen insensitivity10.2
26pulmonary hypertension10.2
27dyspepsia10.2
28eosinophilic gastritis10.2
29polyhydramnios10.2
30polycystic kidney disease10.2
31gastroduodenitis10.2
32nephrocalcinosis10.2
33cutis laxa10.2
34gastric dilatation10.2
35congenital hypothyroidism10.2
36hydronephrosis10.2
37down syndrome10.2
38congenital heart disease10.2
39congenital mesoblastic nephroma10.2
40conjunctivitis10.2
41gastritis10.2
42hypothyroidism10.2
43kidney disease10.2
44neuropathy10.2
45pancreatitis10.2
46ventricular septal defect10.2
47esophageal atresia/tracheoesophageal fistula10.2
48autoimmune gastrointestinal dysmotility10.2
49gastric duplication cysts10.2
50jejunal atresia10.2

Graphical network of the top 20 diseases related to Hypertrophic Pyloric Stenosis:



Diseases related to hypertrophic pyloric stenosis

Symptoms for Hypertrophic Pyloric Stenosis

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Drugs & Therapeutics for Hypertrophic Pyloric Stenosis

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Drug clinical trials:

Search ClinicalTrials for Hypertrophic Pyloric Stenosis

Search NIH Clinical Center for Hypertrophic Pyloric Stenosis

Genetic Tests for Hypertrophic Pyloric Stenosis

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Anatomical Context for Hypertrophic Pyloric Stenosis

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MalaCards organs/tissues related to Hypertrophic Pyloric Stenosis:

31
Smooth muscle, Pancreas, Breast, Brain, Heart, Kidney, Liver, Lung, Testes, Endothelial

Animal Models for Hypertrophic Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Hypertrophic Pyloric Stenosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4NGFR, NKX2-5, HMOX2, NOS1
2MP:00053818.2NOS1, HMOX2, NGFR, GDNF
3MP:00053878.2NOS1, NKX2-5, NGFR, GDNF
4MP:00053978.1GDNF, NGFR, NKX2-5, NOS1
5MP:00053697.8NOS1, HMOX2, NKX2-5, NGFR, GDNF
6MP:00053857.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
7MP:00053867.8GDNF, NGFR, HMOX2, NOS1
8MP:00036317.7GDNF, NGFR, NKX2-5, HMOX2, NOS1
9MP:00107687.6NOS1, HMOX2, NKX2-5, NGFR, GDNF

Publications for Hypertrophic Pyloric Stenosis

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Articles related to Hypertrophic Pyloric Stenosis:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: closing in on the cause. (24787092)
2014
2
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
3
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
4
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
5
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
6
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
7
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
8
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
9
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
10
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
11
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
12
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (14757827)
2004
13
The impact of a clinical guideline on imaging children with hypertrophic pyloric stenosis. (15316693)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
16
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
17
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
18
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
19
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
20
Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)
1999
21
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
22
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
23
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
24
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
25
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
26
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
27
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
28
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
29
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
30
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
31
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
32
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
33
Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. (3582407)
1987
34
Infantile hypertrophic pyloric stenosis in South Central West Virginia. (3478902)
1987
35
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
36
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
37
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
38
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
39
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
40
The reliable sonographic diagnosis of hypertrophic pyloric stenosis. (6427283)
1984
41
Incidence of infantile hypertrophic pyloric stenosis. (6143193)
1984
42
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
43
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
44
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
45
Congenital hypertrophic pyloric stenosis--a 20-year review of 282 surgically treated infants. (7136296)
1982
46
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
47
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
48
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
49
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
50
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979

Variations for Hypertrophic Pyloric Stenosis

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Expression for genes affiliated with Hypertrophic Pyloric Stenosis

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Search GEO for disease gene expression data for Hypertrophic Pyloric Stenosis.

Pathways for genes affiliated with Hypertrophic Pyloric Stenosis

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Pathways related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.4HMOX2, UGT1A1
2
Show member pathways
8.6NOS1, NGFR, GDNF
38.6NOS1, NGFR, GDNF

Compounds for genes affiliated with Hypertrophic Pyloric Stenosis

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Compounds related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 44)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin439.9HMOX2, NOS1
2imipramine43 28 49 24 1213.9UGT1A1, NOS1
3hydroxyurea43 49 1211.8UGT1A1, NOS1
4mptp439.8NOS1, GDNF
5morphine43 49 28 1212.8UGT1A1, NOS1
6capsaicin43 2810.8GDNF, NOS1
7guanylate439.7HMOX2, NOS1
8cgmp43 2810.6NOS1, HMOX2
9carbon439.6NOS1, HMOX2
10cocaine43 1210.5GDNF, NOS1
11peroxynitrite439.5NGFR, NOS1
12FAD249.5NOS1, HMOX2
13heme28 24 1211.5NOS1, HMOX2
14ibuprofen43 28 49 24 1213.5NGFR, UGT1A1
15ganglioside439.4NGFR, GDNF
16dbc-amp439.3NGFR, GDNF
17catecholamine439.3NGFR, GDNF
18genistein43 28 59 2 24 1214.3GDNF, UGT1A1, NOS1
19aspartate439.2GDNF, UGT1A1, NOS1
20arginine439.2NOS1, HMOX2, UGT1A1
21nicotine43 28 49 1212.1NOS1, NGFR, UGT1A1
22indomethacin43 28 59 1212.1NOS1, NGFR, UGT1A1
23nadph43 2410.1NOS1, HMOX2, NGFR
24alanine439.1NOS1, UGT1A1, GDNF
25choline43 24 1211.0GDNF, NGFR, NOS1
26gaba439.0GDNF, NGFR, NOS1
27nmda43 2810.0NOS1, NGFR, GDNF
28progesterone43 28 59 24 1212.9HMOX2, NGFR, UGT1A1
29zinc43 249.9NKX2-5, NGFR, GDNF
30vegf438.9NOS1, NGFR, GDNF
31serine438.5NOS1, NKX2-5, NGFR, GDNF
32acetylcholine43 49 28 24 1212.5NOS1, HMOX2, NGFR, GDNF
33dopamine43 28 24 1211.5GDNF, NGFR, HMOX2, NOS1
34superoxide43 249.5NOS1, HMOX2, NGFR, GDNF
35cysteine438.5GDNF, NGFR, NOS1
36dexamethasone43 49 28 1211.5NOS1, NGFR, UGT1A1, GDNF
37glutamate438.5NOS1, HMOX2, NGFR, GDNF
38oxygen43 249.5NOS1, HMOX2, NGFR, GDNF
39retinoic acid43 249.5GDNF, UGT1A1, NGFR, NOS1
40tyrosine438.3HMOX2, NGFR, UGT1A1, GDNF
41calcium43 49 24 1211.3NOS1, HMOX2, NGFR, GDNF
42glucose438.2HMOX2, NGFR, GDNF
43nitric oxide43 24 1210.1NOS1, HMOX2, NKX2-5, NGFR, GDNF
44estrogen438.0GDNF, UGT1A1, NGFR, HMOX2, NOS1

GO Terms for genes affiliated with Hypertrophic Pyloric Stenosis

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Biological processes related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:00551179.7NKX2-5, NOS1
2heme catabolic processGO:00421679.5HMOX2, UGT1A1
3response to hypoxiaGO:00016669.5HMOX2, NOS1
4porphyrin-containing compound metabolic processGO:00067789.4HMOX2, UGT1A1
5positive regulation of transcription from RNA polymerase II promoterGO:00459448.7NOS1, NKX2-5, GDNF
6negative regulation of apoptotic processGO:00430668.5GDNF, NGFR, NKX2-5

Molecular functions related to Hypertrophic Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:00428038.9NKX2-5, UGT1A1, GDNF

Products for genes affiliated with Hypertrophic Pyloric Stenosis

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Sources for Hypertrophic Pyloric Stenosis

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
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29KEGG
33MeSH
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38NCIt
39NDF-RT
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46OMIM via Orphanet
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56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet